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SPRUE
MCID: CLC063
MIFTS: 72

Celiac Disease 1 (SPRUE)

Categories: Blood diseases, Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Celiac Disease 1

About this section

MalaCards integrated aliases for Celiac Disease 1:

Name: Celiac Disease 1 58 39
Celiac Disease 58 39 12 25 54 26 38 30 56 44 45 15 17 74
Celiac Sprue 12 77 25 54 26
Coeliac Disease 12 77 54 15
Celiac Disease, Susceptibility to 58 13
Gluten-Sensitive Enteropathy 25 54
Nontropical Sprue 25 54
Sprue 26 74
Gluten-Sensitive Enteropathy, Susceptibility to, 1 58
Celiac Disease, Susceptibility to, Type 1 41
Celiac Disease, Susceptibility to, 1 58
Celiac Sprue, Susceptibility to, 1 58
Gluten-Sensitive Enteropathy 1 58
Gluten-Induced Enteropathy 54
Childhood Celiac Disease 74
Idiopathic Steatorrhea 12
Gluten Intolerance 54
Gluten Enteropathy 26
Celiac Sprue 1 58
Celiac1 58

Characteristics:

OMIM:

58
Inheritance:
autosomal recessive
multifactorial

Miscellaneous:
genetic heterogeneity
precipitating factors - ingestion of wheat gluten, rye, and/or barley
presentation in infants - impaired growth, diarrhea, abdominal distention, vomiting
presentation in children - diarrhea, constipation (rarely), short stature, pubertal delay, rickets, iron and folate deficiency with anemia
presentation in adults - episodic or nocturnal diarrhea, flatulence, weight loss, iron deficiency anemia, macrocytic anemia, coagulopathy, vitamin d deficiency


HPO:

33
celiac disease 1:
Inheritance heterogeneous autosomal recessive inheritance multifactorial inheritance


GeneReviews:

25
Penetrance The penetrance of celiac disease is low. the risk of developing celiac disease is affected by hla diplotype (see table 2)...

Classifications:

MalaCards categories:
Global: Genetic diseases Rare diseases
Anatomical: Gastrointestinal diseases Immune diseases Blood diseases
See all MalaCards categories (disease lists)
ICD10: 34


Sources

Summaries for Celiac Disease 1

About this section
NIH Rare Diseases : 54 Celiac disease is an autoimmune disorder that damages the small intestine and inhibits absorption of nutrients. People with celiac disease cannot tolerate gluten, a protein in wheat, rye, barley, and in some products such as medicines, vitamins, and lip balms. When affected people eat food with gluten, or use a product with gluten, the immune system reacts by damaging tiny parts of the lining of the small intestine called villi. Because villi normally allow the blood to absorb nutrients from food, affected individuals become malnourished. Classic signs and symptoms are caused by inflammation of the gastrointestinal tract and may include diarrhea, weight loss, abdominal pain, swelling, and food intolerance. However, many people have other symptoms involving many body systems, and some people have no symptoms. While celiac disease tends to run in families, it does not follow a specific inheritance pattern. The risk to develop celiac disease is raised by having certain forms of the HLA-DQA1 and HLA-DQB1 genes. Treatment is a lifelong, gluten-free diet.

MalaCards based summary : Celiac Disease 1, also known as celiac disease, is related to refractory celiac disease and dermatitis herpetiformis, and has symptoms including constipation, abdominal pain and diarrhea. An important gene associated with Celiac Disease 1 is HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1), and among its related pathways/superpathways are NF-kappaB Signaling and Cell adhesion molecules (CAMs). The drugs Prucalopride and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include testes, small intestine and t cells, and related phenotypes are vitamin b12 deficiency and depressivity

Disease Ontology : 12 An autoimmune disease of gastrointestinal tract that is caused by a reaction located in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has symptom abdominal pain, has symptom constipation, has symptom diarrhea, has symptom nausea and vomiting, and has symptom loss of appetite.

Genetics Home Reference : 26 Celiac disease is a condition in which the immune system is abnormally sensitive to gluten, a protein found in wheat, rye, and barley. Celiac disease is an autoimmune disorder; autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs. Without a strict, lifelong gluten-free diet, inflammation resulting from immune system overactivity may cause a wide variety of signs and symptoms involving many parts of the body.

OMIM : 58 Celiac disease, also known as celiac sprue and gluten-sensitive enteropathy (GSE), is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins (summary by Farrell and Kelly, 2002). Long regarded as gastrointestinal disorder of childhood, the disease is now considered to be a chronic systemic autoimmune disease and is more often diagnosed in adults than in children (Monsuur et al., 2005). For a discussion of genetic heterogeneity of celiac disease, see MAPPING. (212750)

MedlinePlus : 44 Celiac disease is an immune disease in which people can't eat gluten because it will damage their small intestine. If you have celiac disease and eat foods with gluten, your immune system responds by damaging the small intestine. Gluten is a protein found in wheat, rye, and barley. It may also be in other products like vitamins and supplements, hair and skin products, toothpastes, and lip balm. Celiac disease affects each person differently. Symptoms may occur in the digestive system, or in other parts of the body. One person might have diarrhea and abdominal pain, while another person may be irritable or depressed. Irritability is one of the most common symptoms in children. Some people have no symptoms. Celiac disease is genetic. Blood tests can help your doctor diagnose the disease. Your doctor may also need to examine a small piece of tissue from your small intestine. Treatment is a diet free of gluten. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

Wikipedia : 77 Coeliac disease or celiac disease is a long-term autoimmune disorder that primarily affects the small... more...

GeneReviews: NBK1727
Sources

Related Diseases for Celiac Disease 1

About this section

Diseases in the Celiac Disease 1 family:

Celiac Disease 5 Celiac Disease 4
Celiac Disease 2 Celiac Disease 3
Celiac Disease 6 Celiac Disease 7
Celiac Disease 8 Celiac Disease 9
Celiac Disease 10 Celiac Disease 11
Celiac Disease 12 Celiac Disease 13

Diseases related to Celiac Disease 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 673)
# Related Disease Score Top Affiliating Genes
1 refractory celiac disease 34.2 HLA-DQB1 MYO9B
2 dermatitis herpetiformis 32.9 CD79A HLA-DQA1 HLA-DQB1 MYO9B TGM2
3 diabetes mellitus, insulin-dependent 31.4 CTLA4 HLA-DQA1 HLA-DQB1 PTPN22 TPO
4 thyroiditis 31.3 CTLA4 PTPN22 TPO
5 immunoglobulin alpha deficiency 31.2 CD79A HLA-DQB1 TGM2
6 autoimmune disease 31.1 CTLA4 HLA-DQB1 PTPN22 TPO
7 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 31.0 CTLA4 PTPN22 TPO
8 graves' disease 30.9 CTLA4 HLA-DQA1 PTPN22 TPO
9 microscopic colitis 30.8 CD79A HLA-DQB1
10 myxedema 30.7 CTLA4 TPO
11 hashimoto thyroiditis 30.7 CTLA4 PTPN22 TPO
12 guillain-barre syndrome 30.2 CD79A HLA-DQA1 HLA-DQB1
13 acute disseminated encephalomyelitis 30.1 HLA-DQA1 HLA-DQB1
14 celiac disease 4 11.5
15 celiac disease 3 11.5
16 celiac disease 5 11.4
17 celiac disease 2 11.4
18 celiac disease 6 11.4
19 celiac disease 7 11.4
20 celiac disease 8 11.4
21 celiac disease 9 11.4
22 celiac disease 10 11.4
23 celiac disease 11 11.4
24 celiac disease 12 11.4
25 celiac disease 13 11.4
26 down syndrome 11.3
27 osteomalacia 11.3
28 cholangitis, primary sclerosing 11.3
29 iga glomerulonephritis 11.3
30 rickets 11.3
31 collagenous gastritis 11.3
32 whipple disease 11.3
33 autoimmune disease, multisystem, infantile-onset, 1 11.1
34 osmotic diarrhea 11.1
35 epilepsy with bilateral occipital calcifications 11.1
36 epilepsy occipital calcifications 11.1
37 autoimmune polyendocrine syndrome, type ii 11.0
38 bartter syndrome, type 3 11.0
39 diarrhea 5, with tufting enteropathy, congenital 11.0
40 bile acid malabsorption, primary 11.0
41 brittle diabetes 11.0
42 opsoclonus-myoclonus syndrome 11.0
43 myoclonic encephalopathy of infants 11.0
44 diabetes mellitus 10.6
45 congenital toxoplasmosis 10.6 CD79A HLA-DQA1 HLA-DQB1
46 toxoplasmosis 10.6 CD79A HLA-DQA1 HLA-DQB1
47 adult-onset myasthenia gravis 10.6 CTLA4 HLA-DQA1
48 achalasia, familial esophageal 10.6 HLA-DQA1 HLA-DQB1
49 oligoarticular juvenile idiopathic arthritis 10.6 HLA-DQA1 HLA-DQB1 PTPN22
50 autoimmune disease of gastrointestinal tract 10.5 CTLA4 HLA-DQA1 MYO9B TGM2

Comorbidity relations with Celiac Disease 1 via Phenotypic Disease Network (PDN):


Chylomicron Retention Disease Deficiency Anemia
Hypothyroidism Iron Deficiency Anemia
Protein-Energy Malnutrition Tropical Sprue

Graphical network of the top 20 diseases related to Celiac Disease 1:



Diseases related to Celiac Disease 1
Sources

Symptoms & Phenotypes for Celiac Disease 1

About this section

Human phenotypes related to Celiac Disease 1:

33 (show all 43)
# Description HPO Frequency HPO Source Accession
1 vitamin b12 deficiency 33 occasional (7.5%) HP:0100502
2 depressivity 33 HP:0000716
3 seizures 33 HP:0001250
4 ataxia 33 HP:0001251
5 failure to thrive 33 HP:0001508
6 cerebral calcification 33 HP:0002514
7 short stature 33 HP:0004322
8 delayed puberty 33 HP:0000823
9 vomiting 33 HP:0002013
10 rickets 33 HP:0002748
11 type i diabetes mellitus 33 HP:0100651
12 osteoporosis 33 HP:0000939
13 arthralgia 33 HP:0002829
14 abdominal pain 33 HP:0002027
15 weight loss 33 HP:0001824
16 postnatal growth retardation 33 HP:0008897
17 anxiety 33 HP:0000739
18 alopecia 33 HP:0001596
19 celiac disease 33 HP:0002608
20 thyroiditis 33 HP:0100646
21 hypocalcemia 33 HP:0002901
22 iron deficiency anemia 33 HP:0001891
23 thrombocytosis 33 HP:0001894
24 vitamin d deficiency 33 HP:0100512
25 diarrhea 33 HP:0002014
26 eczema 33 HP:0000964
27 lymphoma 33 HP:0002665
28 infertility 33 HP:0000789
29 abdominal distention 33 HP:0003270
30 macrocytic anemia 33 HP:0001972
31 polyneuropathy 33 HP:0001271
32 recurrent aphthous stomatitis 33 HP:0011107
33 abnormality of the coagulation cascade 33 HP:0003256
34 prolonged partial thromboplastin time 33 HP:0003645
35 prolonged prothrombin time 33 HP:0008151
36 vitamin k deficiency 33 HP:0011892
37 steatorrhea 33 HP:0002570
38 hypoplasia of dental enamel 33 HP:0006297
39 abnormality of the abdominal wall 33 HP:0004298
40 stomatitis 33 HP:0010280
41 decreased circulating iga level 33 HP:0002720
42 elevated hepatic transaminase 33 HP:0002910
43 reduced blood folate concentration 33 HP:0100507

Symptoms via clinical synopsis from OMIM:

58
Neurologic Central Nervous System:
seizures
ataxia
cerebral calcification

Growth Height:
short stature

Skeletal Limbs:
arthralgia

Neurologic Peripheral Nervous System:
peripheral neuropathy

Skin Nails Hair Hair:
alopecia

Hematology:
thrombocytosis
iron deficiency anemia (adults)
macrocytic anemia (folate or rarely b12 deficiency)

Head And Neck Mouth:
recurrent aphthous stomatitis

Neoplasia:
esophageal cancer
intestinal t-cell lymphoma
small bowel cancer
pharyngeal cancer

Head And Neck Teeth:
hypoplastic dental enamel

Skeletal:
osteoporosis (70% of patients)

Growth Other:
failure to thrive
growth retardation (children)

Endocrine Features:
delayed puberty
infertility
type 1 diabetes
autoimmune thyroiditis

Growth Weight:
weight loss

Neurologic Behavioral Psychiatric Manifestations:
anxiety
depression

Laboratory Abnormalities:
hypocalcemia
vitamin d deficiency
prolonged prothrombin time
vitamin k deficiency
iiga and igg antigliadin antibodies (aga)
more
Immunology:
iga deficiency

Abdomen Gastrointestinal:
steatorrhea
recurrent abdominal pain
watery diarrhea (children and adults)
small intestine inflammation
flattened villi
more
Skin Nails Hair Skin:
follicular keratosis
dermatitis herpetiformis

Abdomen External Features:
abdominal distention (children)

Clinical features from OMIM:

212750

Symptoms:

12
  • • constipation
  • • abdominal pain
  • • diarrhea
  • • nausea
  • • loss of appetite

UMLS symptoms related to Celiac Disease 1:


nausea and vomiting, constipation, abdominal pain, diarrhea, icterus, dyspepsia, heartburn, gastrointestinal gas
Sources

Drugs & Therapeutics for Celiac Disease 1

About this section

Drugs for Celiac Disease 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 195)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Prucalopride Approved Phase 4 179474-81-8
2
Ethanol Approved Phase 4,Phase 3,Phase 2,Not Applicable 64-17-5 702
3 Ethiodized oil Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 8008-53-5
4
Doxorubicin Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 23214-92-8 31703
5
Pancrelipase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53608-75-6
6
Budesonide Approved Phase 4 51333-22-3 63006 5281004
7
Doxil Approved June 1999 Phase 4,Phase 2,Phase 3,Not Applicable 31703
8 Serotonin Receptor Agonists Phase 4
9 Neurotransmitter Agents Phase 4,Phase 1
10 Serotonin Agents Phase 4
11 Laxatives Phase 4
12 Cathartics Phase 4
13 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
14 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
15 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
16 Hormones Phase 4,Phase 2,Phase 3,Early Phase 1,Not Applicable
17 Anesthetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
18 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Early Phase 1,Not Applicable
19 Hormone Antagonists Phase 4,Phase 2,Phase 3,Early Phase 1,Not Applicable
20 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
21 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
22 Immunologic Factors Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable
23 Vaccines Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
24 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3,Early Phase 1,Not Applicable
25 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3,Early Phase 1,Not Applicable
26 pancreatin Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
27 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
28 Anti-Infective Agents, Local Phase 4,Phase 3,Not Applicable
29 Gentamicins Phase 4
30 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Not Applicable
31 Estrogens Phase 4
32 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3
33 glucocorticoids Phase 4,Phase 2,Phase 3,Not Applicable
34 Autonomic Agents Phase 4,Phase 2,Phase 3
35 Respiratory System Agents Phase 4
36 Bronchodilator Agents Phase 4
37 Anti-Asthmatic Agents Phase 4
38
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202
39
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
40
Epirubicin Approved Phase 3,Phase 2,Not Applicable 56420-45-2 41867
41
Oxaliplatin Approved, Investigational Phase 3,Phase 2 61825-94-3 6857599 5310940 9887054 43805
42
Capecitabine Approved, Investigational Phase 2, Phase 3 154361-50-9 60953
43
Cisplatin Approved Phase 2, Phase 3,Not Applicable 15663-27-1 441203 84093 2767
44
Fluorouracil Approved Phase 3,Not Applicable 51-21-8 3385
45
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
46
Prednisolone phosphate Approved, Vet_approved Phase 2, Phase 3 302-25-0
47
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
48
Methylprednisolone hemisuccinate Approved Phase 2, Phase 3 2921-57-5
49
Simvastatin Approved Phase 2, Phase 3,Phase 1,Not Applicable 79902-63-9 54454
50
Bupivacaine Approved, Investigational Phase 3,Not Applicable 2180-92-9, 38396-39-3 2474

Interventional clinical trials:

(show top 50) (show all 339)
# Name Status NCT ID Phase Drugs
1 Prucalopride Prior to Small Bowel Capsule Endoscopy Unknown status NCT02806206 Phase 4 Prucalopride;Placebo
2 Prospective Study of Celiac Block Injection: 1 vs. 2 Completed NCT00583479 Phase 4
3 Endoscopic Ultrasound-guided Celiac Plexus Neurolysis (EUS-CPN)With Alcohol in Unresectable Pancreatic Cancer: a Pilot Study Completed NCT00578279 Phase 4 dehydrated alcohol
4 Efficacy and Safety of Drug Eluting Beads TACE in Treatment of HCC in Egyptian Patients Completed NCT03007225 Phase 4 Trans-arterial chemoembolization (TACE);TACE with Drug Eluting Beads procedure
5 Effectiveness, Safety and Immunogenicity of GSK Biologicals' HPV Vaccine GSK580299 (Cervarix TM) Administered in Healthy Adolescents Completed NCT00534638 Phase 4
6 Differences in Preparation for Small Bowel Capsule Endoscopy Recruiting NCT03351972 Phase 4 Klean Prep
7 Randomized Crossover Trial for the Evaluation of the Possible Effects in the Intestine of Two Different Pharmaceutical Forms of L - Thyroxine in Patients With Primary Acquired Hypothyroidism Recruiting NCT02917863 Phase 4 L-Thyroxine (tablet, per os);L-Thyroxine (oral drops, solution)
8 Budesonide in Patients With Immune Mediated Enteropathies Recruiting NCT03866538 Phase 4 Withdrawal of Oral Budesonide
9 Pancreatic Enzyme Supplementation for Celiac Disease Enrolling by invitation NCT02475369 Phase 4 pancrelipase
10 Creon Use in Coeliac Patients With Low Faecal Pancreatic Elastase Terminated NCT01865695 Phase 4 Creon
11 Left Celiac Plexus Resection for Pancreatic Cancer at the Body and Tail Unknown status NCT02117895 Phase 3
12 Comparison of SEEOX and SOX Regimens in Stage â…¢B/â…¢C Gastric Cancer Patients Unknown status NCT02338518 Phase 3 oxaliplatin;etoposide;pharmorubicin;S-1
13 Randomized Control Trial (RCT) of Transarterial Chemoembolization (TACE) Versus TACE and Oral Drug Therapy in the Treatment of Unresectable Hepatocellular Carcinoma Unknown status NCT00522405 Phase 2, Phase 3
14 The ARTERY FIRST Approach for Resection of Pancreatic Head Cancer Unknown status NCT01332773 Phase 3
15 Effect of Addition of Short Course of Prednisolone to Gluten Free Diet in Naive Celiac Disease Patients Completed NCT01045837 Phase 2, Phase 3 Prednisolone and Gluten free diet
16 Protocol for Correlating Enteropathic Severity and Small Intestinal CYP3A4 Activity in Patients With Celiac Disease Completed NCT01338324 Phase 2, Phase 3 Simvastatin
17 HLA-DQ2-gliadin Tetramer for Diagnosis of Celiac Disease Completed NCT01100099 Phase 2, Phase 3
18 Intraoperative Celiac Plexus Neurolysis for Patients With Operable Pancreatic and Periampullary Cancer Completed NCT00806611 Phase 3
19 Trial of Endoscopic Ultrasound (EUS) - Guided Celiac Plexus Neurolysis Completed NCT00974948 Phase 3
20 Randomized Trial of EUS Neurolysis in Pancreas Cancer Completed NCT00279292 Phase 3
21 Efficacy of EUS-guided Celiac Plexus Blockade in Chronic Pancreatitis Completed NCT00658736 Phase 3 Triamcinolone;Bupivicaine alone
22 Gluten Sensitivity in Non-Celiac Patients Completed NCT01485341 Phase 3
23 VALOR: The Talent Thoracic Stent Graft System Clinical Study Completed NCT00604799 Phase 2, Phase 3
24 Study to Evaluate Immunogenicity of the Hepatitis B Antigen of the GSK Biologicals' Candidate Malaria Vaccine (257049) Completed NCT01345240 Phase 3
25 Safety and Immunogenicity Study of GlaxoSmithKline (GSK) Biologicals' Measles, Mumps and Rubella (MMR) Vaccine (209762) Compared to Merck & Co., Inc.'s MMR Vaccine in Healthy Children 12 to 15 Months of Age Completed NCT02184572 Phase 3
26 Consistency Study of GlaxoSmithKline (GSK) Biologicals' MMR Vaccine (209762) (Priorix) Comparing Immunogenicity and Safety to Merck & Co., Inc.'s MMR Vaccine (M-M-R II), in Children 12 to 15 Months of Age Completed NCT01702428 Phase 3
27 Immunogenicity and Safety Study of GlaxoSmithKline (GSK) Biologicals' Combined Measles-mumps-rubella (MMR) Vaccine in Children in Their Second Year of Life Completed NCT01681992 Phase 3
28 Resection of the Nerve Plexus on the Right Half of Celiac and SMA Associated With Extended Pancreatoduodenectomy in the Surgical Treatment for Adenocarcinoma of the Head of Pancreas Recruiting NCT02514928 Phase 3
29 Prospective Study on Endoscopic Ultrasound (EUS) Celiac Bloc Efficacy in Chronic Pancreatitis Recruiting NCT01318590 Phase 3 Bupivacaine & Triamcinolone Acetonide
30 Dual Hypothermic Oxygenated Perfusion of DCD Liver Grafts in Preventing Biliary Complications After Transplantation Recruiting NCT02584283 Phase 3 Glutathione
31 Multicenter RCT of ADV-TK Gene Therapy Improving the Outcome of Liver Transplantation for Advanced HCC Recruiting NCT03313596 Phase 3 ADV-Tk
32 Eus-guided Cryothermal Ablation in Stage III Pancreatic Adenocarcinoma Active, not recruiting NCT03649035 Phase 3
33 Assessment of the Effect of Gluten Free Toothpaste on the Ulcerative Events in Children With Celiac Disease Not yet recruiting NCT03771443 Phase 3 experimental gluten free toothpaste
34 Study to Evaluate the Efficacy and Safety of Larazotide Acetate for the Relief of CeD Symptoms Not yet recruiting NCT03569007 Phase 3 Larazotide Acetate;Matching Placebo
35 Phase III Trial Investigating the Potential Benefit of Adjvant Chemotherapy for Small Bowel Adenocarcinoma Not yet recruiting NCT02502370 Phase 3 observation alone;LV5FU2;FOLFOX
36 Adjuvant Radiotherapy for Esophageal Squamous Cell Carcinoma With Positive Circumstantial Resection Margin Not yet recruiting NCT03273647 Phase 3
37 EUS-guided CGN for Inoperable Cancer Terminated NCT02356640 Phase 2, Phase 3 Levobupivacaine
38 A Phase III Study of En Bloc Versus Non-En Bloc Esophagectomy in Esophageal Cancer Terminated NCT00760604 Phase 3
39 Evaluation of the Efficacy and Safety of ALV003 in Symptomatic in Celiac Disease Patients Unknown status NCT01917630 Phase 2 ALV003;placebo
40 Wheat Flour Treatment With Microbial Transglutaminase and Lysine Ethyl Ester: New Frontiers in Celiac Disease Treatment. Unknown status NCT02472119 Phase 2
41 Celiac Plexus Radiosurgery for Pain Management Unknown status NCT02356406 Phase 2
42 Efficacy Study of Acupuncture to Treat the Upper Abdominal Pain of Cancer Patients Unknown status NCT01913574 Phase 2
43 A Double-blind Placebo-controlled Study to Evaluate Larazotide Acetate for the Treatment of Celiac Disease Completed NCT01396213 Phase 2 Larazotide Acetate;placebo
44 Desensitising Celiac Disease Patients With the Human Hookworm Completed NCT01661933 Phase 1, Phase 2
45 Safety and Efficacy of Varying Methods of ALV003 Administration for the Treatment of Celiac Disease Completed NCT01255696 Phase 2
46 Cytokine Profile in Children With Celiac Disease Completed NCT02244047 Phase 1, Phase 2 Bifidobacterium breve;Placebo (for Bifidobacterium breve)
47 Randomized, Double-Blind, Placebo-Controlled Study of Larazotide Acetate in Subjects With Active Celiac Disease Completed NCT00620451 Phase 2 larazotide acetate;placebo
48 Safety and Efficacy of ALV003 for the Treatment of Celiac Disease Completed NCT00959114 Phase 2
49 A Phase II Study of CCX282-B in Patients With Celiac Disease Completed NCT00540657 Phase 2 CCX282-B;Placebo
50 Bifidobacterium Infantis NLS Super Strain for Celiac Disease Patients on a Gluten-free Diet With Persistent Gastrointestinal Symptoms Completed NCT03271138 Phase 2

Search NIH Clinical Center for Celiac Disease 1

Inferred drug relations via UMLS 74 / NDF-RT 52 :


Cell-based therapeutics:


LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Celiac Disease 1 cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Celiac Disease 1:
Regenerative ColoTherapy�, stem cells for inflammatory bowel diseases
Embryonic/Adult Cultured Cells Related to Celiac Disease 1:
Adipose-derived mesenchymal stem cells (family)
Peripheral blood-derived hematopoietic stem cells (family)

Cochrane evidence based reviews: celiac disease

Sources

Genetic Tests for Celiac Disease 1

About this section

Genetic tests related to Celiac Disease 1:

# Genetic test Affiliating Genes
1 Celiac Disease 30 HLA-DQA1 HLA-DQB1
Sources

Anatomical Context for Celiac Disease 1

About this section

MalaCards organs/tissues related to Celiac Disease 1:

42
Testes, Small Intestine, T Cells, Thyroid, Liver, Bone, Skin

The Foundational Model of Anatomy Ontology organs/tissues related to Celiac Disease 1:

20
Small Intestine To Gliadin
Sources

Publications for Celiac Disease 1

About this section

Articles related to Celiac Disease 1:

(show top 50) (show all 3905)
# Title Authors Year
1
Resolution of celiac disease, IgA deficiency and platelet refractoriness after allogeneic bone marrow transplantation for acute leukemia. ( 30655374 )
2019
2
Assessment of Quality of Life, Anxiety and Depressive Symptoms in Serbian Children with Celiac Disease and their Parents. ( 30637682 )
2019
3
Dietary Gluten Intake and Risk of Microscopic Colitis Among US Women without Celiac Disease: A Prospective Cohort Study. ( 30181535 )
2019
4
A pathogenic role for cystic fibrosis transmembrane conductance regulator in celiac disease. ( 30498130 )
2019
5
Prevalence and characteristics of celiac disease in South African patients with type 1 diabetes mellitus: Results from the Durban Diabetes and Celiac Disease Study. ( 30600564 )
2019
6
Headache in Patients with Celiac Disease and Its Response to the Gluten-Free Diet. ( 30893404 )
2019
7
Neurological Manifestations of Neuropathy and Ataxia in Celiac Disease: A Systematic Review. ( 30759885 )
2019
8
Prevalence of osteoporosis and osteopenia in men and premenopausal women with celiac disease: a systematic review. ( 30732599 )
2019
9
Refractory Celiac Disease. ( 30711206 )
2019
10
Identifying True Celiac Disease and Wheat Allergy in the Era of Fashion Driven Gluten-Free Diets. ( 30897589 )
2019
11
Impact of bariatric surgery on outcomes of patients with celiac disease: a nationwide inpatient sample analysis, 2004-2014. ( 30598595 )
2019
12
Celiac disease among at-risk individuals in Saudi Arabia. ( 30617375 )
2019
13
An unusual Chinese case of celiac disease presenting as hypocalcemia and low bone density. ( 30631967 )
2019
14
A Functional Idiotype/Anti-Idiotype Network Is Active in Genetically Gluten-Intolerant Individuals Negative for Both Celiac Disease-Related Intestinal Damage and Serum Autoantibodies. ( 30635394 )
2019
15
Letter: Celiac Disease Presenting After a Single Anastomosis Duodeno-Ileal Bypass and Sleeve Gastrectomy. ( 30637519 )
2019
16
Color masking improves classification of celiac disease in videocapsule endoscopy images. ( 30638623 )
2019
17
Autoimmunity in celiac disease: Extra-intestinal manifestations. ( 30639642 )
2019
18
Pediatric Celiac Disease in Central and East Asia: Current Knowledge and Prevalence. ( 30642036 )
2019
19
Online education for gluten-free diet teaching: Development and usability testing of an e-learning module for children with concurrent celiac disease and type 1 diabetes. ( 30652421 )
2019
20
IgA anti-tissue transglutaminase antibodies and IgG antibodies against deamidated gliadin peptides as predictors of celiac disease. ( 30652447 )
2019
21
Content of widely viewed YouTube videos about celiac disease. ( 30682698 )
2019
22
Current Evidence in the Diagnosis and Treatment of Children With Celiac Disease. ( 30688706 )
2019
23
Current Evidence in the Diagnosis and Treatment of Children With Celiac Disease. ( 30688707 )
2019
24
Is Adherence to a Gluten-Free Diet by Adult Patients With Celiac Disease Influenced by Their Knowledge of the Gluten Content of Foods? ( 30688709 )
2019
25
Intestinal Spirocheteosis in a Patient with Celiac Disease. ( 30700359 )
2019
26
Epidemiology of Celiac Disease. ( 30711202 )
2019
27
Celiac Disease in Asia. ( 30711203 )
2019
28
The Microbiome in Celiac Disease. ( 30711204 )
2019
29
Follow-up of Celiac Disease. ( 30711205 )
2019
30
Nondietary Therapies for Celiac Disease. ( 30711207 )
2019
31
Celiac Disease: Clinical Features and Diagnosis. ( 30711209 )
2019
32
Biopsy Diagnosis of Celiac Disease: The Pathologist's Perspective in Light of Recent Advances. ( 30711210 )
2019
33
Capsule Endoscopy and Enteroscopy in Celiac Disease. ( 30711212 )
2019
34
(Outcome) Measure for (Intervention) Measures: A Guide to Choosing the Appropriate Noninvasive Clinical Outcome Measure for Intervention Studies in Celiac Disease. ( 30711213 )
2019
35
Celiac Disease, Gluten-Free, and Today's Fashionista. ( 30711214 )
2019
36
New Developments in Celiac Disease. ( 30711215 )
2019
37
Gluten-Induced Extra-Intestinal Manifestations in Potential Celiac Disease-Celiac Trait. ( 30717318 )
2019
38
Gluten in Celiac Disease-More or Less? ( 30720425 )
2019
39
Pigment Epithelium-Derived Factor Affects Angiogenesis in Celiac Disease. ( 30726852 )
2019
40
Defective proteostasis in celiac disease as a new therapeutic target. ( 30737369 )
2019
41
Prevalence of celiac disease in a large cohort of young patients with type 1 diabetes. ( 30737863 )
2019
42
Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease. ( 30739797 )
2019
43
Celiac crisis, a rare occurrence in adult celiac disease: A systematic review. ( 30746372 )
2019
44
Classical celiac disease is more frequent with a double dose of HLA-DQB1*02: A systematic review with meta-analysis. ( 30763397 )
2019
45
Long-Term Outcome of Potential Celiac Disease in Genetically at-Risk Children: The Prospective CELIPREV Cohort Study. ( 30764503 )
2019
46
Role of Front-of-Package Gluten-Free Product Labeling in a Pair-Matched Study in Women with and without Celiac Disease on a Gluten-Free Diet. ( 30769829 )
2019
47
Protective Effects of Aryl Hydrocarbon Receptor Signaling in Celiac Disease Mucosa and in Poly I:C-Induced Small Intestinal Atrophy Mouse Model. ( 30778350 )
2019
48
Fibre-enriched buckwheat pasta modifies blood glucose response compared to corn pasta in individuals with type 1 diabetes and celiac disease: acute randomized controlled trial. ( 30779970 )
2019
49
Celiac Disease Screening in Infertile Women: Is It Worth It? ( 30784566 )
2019
50
Narrow band imaging evaluation of duodenal villi in patients with and without celiac disease: A prospective study. ( 30788033 )
2019
Sources

Variations for Celiac Disease 1

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Sources

Expression for Celiac Disease 1

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Search GEO for disease gene expression data for Celiac Disease 1.
Sources

Pathways for Celiac Disease 1

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Pathways related to Celiac Disease 1 according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
NF-kappaB Signaling 4
12.07 CD79A CTLA4 IRF1 PTPN22
2
Cell adhesion molecules (CAMs) 38
11.66 CTLA4 HLA-DQA1 HLA-DQB1
3
Translocation of ZAP-70 to Immunological synapse 67
Show member pathways
 11.37 HLA-DQA1 HLA-DQB1 PTPN22
4
Rheumatoid arthritis 38
11.09 CTLA4 HLA-DQA1 HLA-DQB1
5
CTLA4 Signaling 65
10.78 CTLA4 HLA-DQA1 HLA-DQB1 PTPN22
Sources

GO Terms for Celiac Disease 1

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Cellular components related to Celiac Disease 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of lumenal side of endoplasmic reticulum membrane GO:0071556 8.96 HLA-DQA1 HLA-DQB1
2 MHC class II protein complex GO:0042613 8.62 HLA-DQA1 HLA-DQB1

Biological processes related to Celiac Disease 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell receptor signaling pathway GO:0050852 9.54 HLA-DQA1 HLA-DQB1 PTPN22
2 interferon-gamma-mediated signaling pathway GO:0060333 9.33 HLA-DQA1 HLA-DQB1 IRF1
3 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.32 HLA-DQA1 HLA-DQB1
4 regulation of innate immune response GO:0045088 9.26 IRF1 PTPN22
5 immune system process GO:0002376 9.1 CD79A CTLA4 HLA-DQA1 IRF1 KLRK1 PTPN22
6 negative regulation of regulatory T cell differentiation GO:0045590 8.96 CTLA4 IRF1

Molecular functions related to Celiac Disease 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 8.62 HLA-DQA1 HLA-DQB1
Sources

Sources for Celiac Disease 1

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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