Celiac Disease 1

Categories: Genetic diseases, Rare diseases, Gastrointestinal diseases, Immune diseases

Aliases & Classifications for Celiac Disease 1

MalaCards integrated aliases for Celiac Disease 1:

Name: Celiac Disease 1 57 38
Celiac Disease 57 38 12 24 53 25 29 55 43 44 15 73
Celiac Sprue 12 76 24 53 25
Coeliac Disease 12 76 53
Celiac Disease, Susceptibility to 57 13
Gluten-Sensitive Enteropathy 24 53
Nontropical Sprue 24 53
Sprue 25 73
Gluten-Sensitive Enteropathy, Susceptibility to, 1 57
Celiac Disease, Susceptibility to, Type 1 40
Celiac Disease, Susceptibility to, 1 57
Celiac Sprue, Susceptibility to, 1 57
Gluten-Sensitive Enteropathy 1 57
Gluten-Induced Enteropathy 53
Childhood Celiac Disease 73
Idiopathic Steatorrhea 12
Gluten Intolerance 53
Gluten Enteropathy 25
Celiac Sprue 1 57
Cœliac Disease 24
Celiac1 57



autosomal recessive

genetic heterogeneity
precipitating factors - ingestion of wheat gluten, rye, and/or barley
presentation in infants - impaired growth, diarrhea, abdominal distention, vomiting
presentation in children - diarrhea, constipation (rarely), short stature, pubertal delay, rickets, iron and folate deficiency with anemia
presentation in adults - episodic or nocturnal diarrhea, flatulence, weight loss, iron deficiency anemia, macrocytic anemia, coagulopathy, vitamin d deficiency


Penetrance The penetrance of celiac disease is low. of individuals with a celiac-associated hla allele genotype, approximately 3% develop celiac disease. see testing strategies, in a symptomatic individual who is on a gluten-free diet, molecular genetic testing and table 3. see genetic counseling for details regarding risk to family members...


Summaries for Celiac Disease 1

NIH Rare Diseases : 53 Celiac disease is an autoimmune disorder that damages the small intestine and inhibits absorption of nutrients. People with celiac disease cannot tolerate gluten, a protein in wheat, rye, barley, and in some products such as medicines, vitamins, and lip balms. When affected people eat food with gluten, or use a product with gluten, the immune system reacts by damaging tiny parts of the lining of the small intestine called villi. Because villi normally allow the blood to absorb nutrients from food, affected individuals become malnourished. Classic signs and symptoms are caused by inflammation of the gastrointestinal tract and may include diarrhea, weight loss, abdominal pain, swelling, and food intolerance. However, many people have other symptoms involving many body systems, and some people have no symptoms. While celiac disease tends to run in families, it does not follow a specific inheritance pattern. The risk to develop celiac disease is raised by having certain forms of the HLA-DQA1 and HLA-DQB1 genes. Treatment is a lifelong, gluten-free diet.

MalaCards based summary : Celiac Disease 1, also known as celiac disease, is related to dermatitis herpetiformis and thyroiditis, and has symptoms including abdominal pain, constipation and diarrhea. An important gene associated with Celiac Disease 1 is HLA-DQB1 (Major Histocompatibility Complex, Class II, DQ Beta 1), and among its related pathways/superpathways are Allograft rejection and NF-kappaB Signaling. The drugs Ethanol and Doxorubicin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, testes and thyroid, and related phenotypes are depressivity and seizures

OMIM : 57 Celiac disease, also known as celiac sprue and gluten-sensitive enteropathy (GSE), is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins (summary by Farrell and Kelly, 2002). Long regarded as gastrointestinal disorder of childhood, the disease is now considered to be a chronic systemic autoimmune disease and is more often diagnosed in adults than in children (Monsuur et al., 2005). For a discussion of genetic heterogeneity of celiac disease, see MAPPING. (212750)

MedlinePlus : 43 Celiac disease is an immune disease in which people can't eat gluten because it will damage their small intestine. If you have celiac disease and eat foods with gluten, your immune system responds by damaging the small intestine. Gluten is a protein found in wheat, rye, and barley. It may also be in other products like vitamins and supplements, hair and skin products, toothpastes, and lip balm. Celiac disease affects each person differently. Symptoms may occur in the digestive system, or in other parts of the body. One person might have diarrhea and abdominal pain, while another person may be irritable or depressed. Irritability is one of the most common symptoms in children. Some people have no symptoms. Celiac disease is genetic. Blood tests can help your doctor diagnose the disease. Your doctor may also need to examine a small piece of tissue from your small intestine. Treatment is a diet free of gluten. NIH: National Institute of Diabetes and Digestive and Kidney Diseases

Genetics Home Reference : 25 Celiac disease is a condition in which the immune system is abnormally sensitive to gluten, a protein found in wheat, rye, and barley. Celiac disease is an autoimmune disorder; autoimmune disorders occur when the immune system malfunctions and attacks the body's own tissues and organs. Without a strict, lifelong gluten-free diet, inflammation resulting from immune system overactivity may cause a wide variety of signs and symptoms involving many parts of the body.

Disease Ontology : 12 An autoimmune disease of gastrointestinal tract that is caused by a reaction located in small intestine to gliadin, a prolamin (gluten protein) found in wheat, and similar proteins found in the crops of the tribe Triticeae. The disease is associated with HLA-DQ gene. It has symptom abdominal pain, has symptom constipation, has symptom diarrhea, has symptom nausea and vomiting, and has symptom loss of appetite.

Wikipedia : 76 Coeliac disease, also spelled celiac disease, is a long-term autoimmune disorder that primarily affects... more...

GeneReviews: NBK1727

Related Diseases for Celiac Disease 1

Diseases in the Celiac Disease 1 family:

Celiac Disease 5 Celiac Disease 4
Celiac Disease 2 Celiac Disease 3
Celiac Disease 6 Celiac Disease 7
Celiac Disease 8 Celiac Disease 9
Celiac Disease 10 Celiac Disease 11
Celiac Disease 12 Celiac Disease 13

Diseases related to Celiac Disease 1 via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 239)
# Related Disease Score Top Affiliating Genes
1 dermatitis herpetiformis 32.3 CD79A HLA-DQA1 HLA-DQB1 MYO9B TGM2
2 thyroiditis 31.8 CTLA4 PTPN22 TG TPO
3 refractory celiac disease 31.7 HLA-DQB1 MYO9B
4 immunoglobulin alpha deficiency 31.6 CD79A HLA-DQB1 TGM2
5 primary biliary cholangitis 31.5 CTLA4 PTPN22
6 alpha/beta t-cell lymphopenia with gamma/delta t-cell expansion, severe cytomegalovirus infection, and autoimmunity 31.4 CTLA4 PTPN22 TG TPO
7 rheumatoid arthritis 31.3 CD79A CTLA4 HLA-DQA1 HLA-DQB1 PTPN22
8 neonatal hypothyroidism 31.2 TG TPO
9 autoimmune disease 31.2 CD79A CTLA4 HLA-DQA1 HLA-DQB1 PTPN22 TG
10 hyperthyroidism 31.1 CTLA4 TG TPO
11 graves' disease 31.0 CTLA4 HLA-DQA1 PTPN22 TG TPO
12 inflammatory bowel disease 30.8 CTLA4 HLA-DQA1 HLA-DQB1 MYO9B PTPN22
13 systemic lupus erythematosus 30.8 CD79A CTLA4 HLA-DQA1 HLA-DQB1 PTPN22
14 achalasia, familial esophageal 11.3 HLA-DQA1 HLA-DQB1
15 adult-onset myasthenia gravis 11.3 CTLA4 HLA-DQA1
16 focal epithelial hyperplasia 11.3 HLA-DQA1 HLA-DQB1
17 celiac disease 4 11.3
18 celiac disease 3 11.3
19 congenital toxoplasmosis 11.3 CD79A HLA-DQA1 HLA-DQB1
20 gluten allergy 11.3 CD79A TGM2
21 oligoarticular juvenile idiopathic arthritis 11.3 HLA-DQA1 HLA-DQB1 PTPN22
22 recurrent respiratory papillomatosis 11.3 HLA-DQA1 HLA-DQB1
23 geographic tongue 11.3 CD79A HLA-DQB1 TGM2
24 familial thyroid dyshormonogenesis 11.3 TG TPO
25 toxoplasmosis 11.2 CD79A HLA-DQA1 HLA-DQB1
26 vogt-koyanagi-harada disease 11.2 HLA-DQA1 HLA-DQB1 PTPN22
27 subacute lymphocytic thyroiditis 11.2 TG TPO
28 substernal goiter 11.2 CD79A TG
29 enteropathy-associated t-cell lymphoma 11.2
30 wheat allergy 11.2 CD79A TGM2
31 autoimmune addison disease 11.2 CTLA4 PTPN22
32 autoimmune pancreatitis 11.2 CTLA4 HLA-DQB1
33 celiac disease 5 11.2
34 celiac disease 2 11.2
35 celiac disease 6 11.2
36 celiac disease 7 11.2
37 celiac disease 8 11.2
38 celiac disease 9 11.2
39 celiac disease 10 11.2
40 celiac disease 11 11.2
41 celiac disease 12 11.2
42 celiac disease 13 11.2
43 goiter, multinodular 1, with or without sertoli-leydig cell tumors 11.2 TG TPO
44 myxedema 11.2 CTLA4 TG TPO
45 hypoadrenocorticism, familial 11.2 CTLA4 PTPN22 TPO
46 vitiligo-associated multiple autoimmune disease susceptibility 1 11.2 CTLA4 PTPN22 TPO
47 anterior uveitis 11.2 CTLA4 PTPN22
48 endemic goiter 11.1 TG TPO
49 immune system disease 11.1 CD79A CTLA4 TG TGM2
50 autoimmune disease of endocrine system 11.1 CTLA4 PTPN22 TG TPO

Comorbidity relations with Celiac Disease 1 via Phenotypic Disease Network (PDN):

Chylomicron Retention Disease Deficiency Anemia
Hypothyroidism Iron Deficiency Anemia
Protein-Energy Malnutrition Tropical Sprue

Graphical network of the top 20 diseases related to Celiac Disease 1:

Diseases related to Celiac Disease 1

Symptoms & Phenotypes for Celiac Disease 1

Symptoms via clinical synopsis from OMIM:

Neurologic Central Nervous System:
cerebral calcification

Growth Height:
short stature

Skeletal Limbs:

Neurologic Peripheral Nervous System:
peripheral neuropathy

Skin Nails Hair Hair:

iron deficiency anemia (adults)
macrocytic anemia (folate or rarely b12 deficiency)

Head And Neck Mouth:
recurrent aphthous stomatitis

esophageal cancer
intestinal t-cell lymphoma
small bowel cancer
pharyngeal cancer

Head And Neck Teeth:
hypoplastic dental enamel

osteoporosis (70% of patients)

Growth Other:
failure to thrive
growth retardation (children)

Endocrine Features:
delayed puberty
type 1 diabetes
autoimmune thyroiditis

Growth Weight:
weight loss

Neurologic Behavioral Psychiatric Manifestations:

Laboratory Abnormalities:
vitamin d deficiency
prolonged prothrombin time
vitamin k deficiency
iiga and igg antigliadin antibodies (aga)
iga deficiency

Abdomen Gastrointestinal:
recurrent abdominal pain
watery diarrhea (children and adults)
small intestine inflammation
flattened villi
Skin Nails Hair Skin:
follicular keratosis
dermatitis herpetiformis

Abdomen External Features:
abdominal distention (children)

Clinical features from OMIM:



  • abdominal pain
  • constipation
  • diarrhea
  • nausea
  • loss of appetite

Human phenotypes related to Celiac Disease 1:

32 (show all 42)
# Description HPO Frequency HPO Source Accession
1 depressivity 32 HP:0000716
2 seizures 32 HP:0001250
3 ataxia 32 HP:0001251
4 failure to thrive 32 HP:0001508
5 cerebral calcification 32 HP:0002514
6 short stature 32 HP:0004322
7 delayed puberty 32 HP:0000823
8 vomiting 32 HP:0002013
9 rickets 32 HP:0002748
10 type i diabetes mellitus 32 HP:0100651
11 osteoporosis 32 HP:0000939
12 arthralgia 32 HP:0002829
13 abdominal pain 32 HP:0002027
14 weight loss 32 HP:0001824
15 postnatal growth retardation 32 HP:0008897
16 anxiety 32 HP:0000739
17 elevated hepatic transaminases 32 HP:0002910
18 alopecia 32 HP:0001596
19 celiac disease 32 HP:0002608
20 hypocalcemia 32 HP:0002901
21 iron deficiency anemia 32 HP:0001891
22 thrombocytosis 32 HP:0001894
23 vitamin d deficiency 32 HP:0100512
24 diarrhea 32 HP:0002014
25 eczema 32 HP:0000964
26 lymphoma 32 HP:0002665
27 infertility 32 HP:0000789
28 abdominal distention 32 HP:0003270
29 iga deficiency 32 HP:0002720
30 macrocytic anemia 32 HP:0001972
31 polyneuropathy 32 HP:0001271
32 recurrent aphthous stomatitis 32 HP:0011107
33 prolonged partial thromboplastin time 32 HP:0003645
34 prolonged prothrombin time 32 HP:0008151
35 vitamin k deficiency 32 HP:0011892
36 steatorrhea 32 HP:0002570
37 hypoplasia of dental enamel 32 HP:0006297
38 abnormality of the coagulation cascade 32 HP:0003256
39 abnormality of the abdominal wall 32 HP:0004298
40 stomatitis 32 HP:0010280
41 folate deficiency 32 HP:0100507
42 vitamin b12 deficiency 32 occasional (7.5%) HP:0100502

UMLS symptoms related to Celiac Disease 1:

abdominal pain, constipation, diarrhea, dyspepsia, heartburn, icterus, nausea and vomiting, gastrointestinal gas

MGI Mouse Phenotypes related to Celiac Disease 1:

# Description MGI Source Accession Score Top Affiliating Genes
1 endocrine/exocrine gland MP:0005379 9.56 TG TGM2 TPO CTLA4 HLA-DQA1 HLA-DQB1
2 hematopoietic system MP:0005397 9.32 CD79A CTLA4 HLA-DQA1 HLA-DQB1 IRF1 MYO9B

Drugs & Therapeutics for Celiac Disease 1

Drugs for Celiac Disease 1 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 166)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Ethanol Approved Phase 4,Phase 3,Phase 2,Not Applicable 64-17-5 702
Doxorubicin Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 23214-92-8 31703
Ethiodized oil Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 8008-53-5
Pancrelipase Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 53608-75-6
Doxil Approved June 1999 Phase 4,Phase 2,Phase 3,Not Applicable 31703
6 Anti-Infective Agents Phase 4,Phase 3,Phase 2,Not Applicable
7 Anesthetics Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable
8 Anti-Bacterial Agents Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
9 Antibiotics, Antitubercular Phase 4,Phase 3,Phase 2,Not Applicable,Early Phase 1
10 Hormone Antagonists Phase 4,Phase 2,Phase 3,Early Phase 1,Not Applicable
11 Hormones Phase 4,Phase 2,Phase 3,Early Phase 1,Not Applicable
12 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3,Early Phase 1,Not Applicable
13 Topoisomerase Inhibitors Phase 4,Phase 3,Phase 2,Not Applicable
14 Vaccines Phase 4,Phase 3,Phase 1,Phase 2,Not Applicable
15 Gastrointestinal Agents Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable
16 pancreatin Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1
17 Anti-Infective Agents, Local Phase 4,Phase 3,Not Applicable
18 Central Nervous System Depressants Phase 4,Phase 3,Phase 2,Not Applicable
19 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3
20 Estrogens Phase 4
21 Gentamicins Phase 4
22 Pharmaceutical Solutions Phase 4,Phase 3,Phase 2,Not Applicable
Capecitabine Approved, Investigational Phase 2, Phase 3 154361-50-9 60953
Cisplatin Approved Phase 2, Phase 3,Not Applicable 15663-27-1 84093 441203 2767
Fluorouracil Approved Phase 3,Not Applicable 51-21-8 3385
Methylprednisolone Approved, Vet_approved Phase 2, Phase 3 83-43-2 6741
Prednisolone Approved, Vet_approved Phase 2, Phase 3 50-24-8 5755
Simvastatin Approved Phase 2, Phase 3,Phase 1,Not Applicable 79902-63-9 54454
Menthol Approved Phase 2, Phase 3 2216-51-5 16666
Bupivacaine Approved, Investigational Phase 3,Not Applicable 2180-92-9, 38396-39-3 2474
Triamcinolone Approved, Vet_approved Phase 3,Not Applicable 124-94-7 31307
Epirubicin Approved Phase 3,Phase 2,Not Applicable 56420-45-2 41867
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
Oxaliplatin Approved, Investigational Phase 3,Phase 2 61825-94-3 5310940 9887054 43805 6857599
Levobupivacaine Approved, Investigational Phase 2, Phase 3 27262-47-1 92253
36 Anti-Inflammatory Agents Phase 2, Phase 3,Phase 3,Early Phase 1,Not Applicable
37 Peripheral Nervous System Agents Phase 2, Phase 3,Phase 3,Early Phase 1,Not Applicable
38 Antimetabolites Phase 2, Phase 3,Phase 1,Not Applicable
39 Immunosuppressive Agents Phase 3,Phase 2,Not Applicable
40 Antiemetics Phase 2, Phase 3
41 Autonomic Agents Phase 2, Phase 3
42 glucocorticoids Phase 2, Phase 3,Phase 3,Not Applicable
43 Methylprednisolone acetate Phase 2, Phase 3
44 Methylprednisolone Hemisuccinate Phase 2, Phase 3
45 Neuroprotective Agents Phase 2, Phase 3
46 Prednisolone acetate Phase 2, Phase 3
47 Prednisolone hemisuccinate Phase 2, Phase 3
48 Prednisolone phosphate Phase 2, Phase 3
49 Protective Agents Phase 2, Phase 3
50 Anticholesteremic Agents Phase 2, Phase 3,Phase 1,Not Applicable

Interventional clinical trials:

(show top 50) (show all 307)
# Name Status NCT ID Phase Drugs
1 Prucalopride Prior to Small Bowel Capsule Endoscopy Unknown status NCT02806206 Phase 4 Prucalopride;Placebo
2 Prospective Study of Celiac Block Injection: 1 vs. 2 Completed NCT00583479 Phase 4
3 Endoscopic Ultrasound-guided Celiac Plexus Neurolysis (EUS-CPN)With Alcohol in Unresectable Pancreatic Cancer: a Pilot Study Completed NCT00578279 Phase 4 dehydrated alcohol
4 Efficacy and Safety of Drug Eluting Beads TACE in Treatment of HCC in Egyptian Patients Completed NCT03007225 Phase 4 Trans-arterial chemoembolization (TACE);TACE with Drug Eluting Beads procedure
5 Effectiveness, Safety and Immunogenicity of GSK Biologicals' HPV Vaccine GSK580299 (Cervarix TM) Administered in Healthy Adolescents Completed NCT00534638 Phase 4
6 Pancreatic Enzyme Supplementation for Celiac Disease Recruiting NCT02475369 Phase 4 pancrelipase
7 Differences in Preparation for Small Bowel Capsule Endoscopy Recruiting NCT03351972 Phase 4 Klean Prep
8 Randomized Crossover Trial for the Evaluation of the Possible Effects in the Intestine of Two Different Pharmaceutical Forms of L - Thyroxine in Patients With Primary Acquired Hypothyroidism Recruiting NCT02917863 Phase 4 L-Thyroxine (tablet, per os);L-Thyroxine (oral drops, solution)
9 Creon Use in Coeliac Patients With Low Faecal Pancreatic Elastase Terminated NCT01865695 Phase 4 Creon
10 Randomized Control Trial (RCT) of Transarterial Chemoembolization (TACE) Versus TACE and Oral Drug Therapy in the Treatment of Unresectable Hepatocellular Carcinoma Unknown status NCT00522405 Phase 2, Phase 3
11 The ARTERY FIRST Approach for Resection of Pancreatic Head Cancer Unknown status NCT01332773 Phase 3
12 Effect of Addition of Short Course of Prednisolone to Gluten Free Diet in Naive Celiac Disease Patients Completed NCT01045837 Phase 2, Phase 3 Prednisolone and Gluten free diet
13 Protocol for Correlating Enteropathic Severity and Small Intestinal CYP3A4 Activity in Patients With Celiac Disease Completed NCT01338324 Phase 2, Phase 3 Simvastatin
14 HLA-DQ2-gliadin Tetramer for Diagnosis of Celiac Disease Completed NCT01100099 Phase 2, Phase 3
15 Intraoperative Celiac Plexus Neurolysis for Patients With Operable Pancreatic and Periampullary Cancer Completed NCT00806611 Phase 3
16 Trial of Endoscopic Ultrasound (EUS) - Guided Celiac Plexus Neurolysis Completed NCT00974948 Phase 3
17 Randomized Trial of EUS Neurolysis in Pancreas Cancer Completed NCT00279292 Phase 3
18 Efficacy of EUS-guided Celiac Plexus Blockade in Chronic Pancreatitis Completed NCT00658736 Phase 3 Triamcinolone;Bupivicaine alone
19 Gluten Sensitivity in Non-Celiac Patients Completed NCT01485341 Phase 3
20 VALOR: The Talent Thoracic Stent Graft System Clinical Study Completed NCT00604799 Phase 2, Phase 3
21 Study to Evaluate Immunogenicity of the Hepatitis B Antigen of the GSK Biologicals' Candidate Malaria Vaccine (257049) Completed NCT01345240 Phase 3
22 Safety and Immunogenicity Study of GlaxoSmithKline (GSK) Biologicals' Measles, Mumps and Rubella (MMR) Vaccine (209762) Compared to Merck & Co., Inc.'s MMR Vaccine in Healthy Children 12 to 15 Months of Age Completed NCT02184572 Phase 3
23 Consistency Study of GlaxoSmithKline (GSK) Biologicals' MMR Vaccine (209762) (Priorix) Comparing Immunogenicity and Safety to Merck & Co., Inc.'s MMR Vaccine (M-M-R II), in Children 12 to 15 Months of Age Completed NCT01702428 Phase 3
24 Left Celiac Plexus Resection for Pancreatic Cancer at the Body and Tail Recruiting NCT02117895 Phase 3
25 Resection of the Nerve Plexus on the Right Half of Celiac and SMA Associated With Extended Pancreatoduodenectomy in the Surgical Treatment for Adenocarcinoma of the Head of Pancreas Recruiting NCT02514928 Phase 3
26 Prospective Study on Endoscopic Ultrasound (EUS) Celiac Bloc Efficacy in Chronic Pancreatitis Recruiting NCT01318590 Phase 3 Bupivacaine & Triamcinolone Acetonide
27 Comparison of SEEOX and SOX Regimens in Stage ⅢB/ⅢC Gastric Cancer Patients Recruiting NCT02338518 Phase 3 oxaliplatin;etoposide;pharmorubicin;S-1
28 Dual Hypothermic Oxygenated Perfusion of DCD Liver Grafts in Preventing Biliary Complications After Transplantation Recruiting NCT02584283 Phase 3 Glutathione
29 Multicenter RCT of ADV-TK Gene Therapy Improving the Outcome of Liver Transplantation for Advanced HCC Recruiting NCT03313596 Phase 3 ADV-Tk
30 Study to Evaluate the Efficacy and Safety of Larazotide Acetate for the Treatment of Celiac Disease Not yet recruiting NCT03569007 Phase 3 Larazotide Acetate;Matching Placebo
31 Phase III Trial Investigating the Potential Benefit of Adjvant Chemotherapy for Small Bowel Adenocarcinoma Not yet recruiting NCT02502370 Phase 3 observation alone;LV5FU2;FOLFOX
32 Adjuvant Radiotherapy for Esophageal Squamous Cell Carcinoma With Positive Circumstantial Resection Margin Not yet recruiting NCT03273647 Phase 3
33 EUS-guided CGN for Inoperable Cancer Suspended NCT02356640 Phase 2, Phase 3 Levobupivacaine
34 A Phase III Study of En Bloc Versus Non-En Bloc Esophagectomy in Esophageal Cancer Terminated NCT00760604 Phase 3
35 Evaluation of the Efficacy and Safety of ALV003 in Symptomatic in Celiac Disease Patients Unknown status NCT01917630 Phase 2 ALV003;placebo
36 Wheat Flour Treatment With Microbial Transglutaminase and Lysine Ethyl Ester: New Frontiers in Celiac Disease Treatment. Unknown status NCT02472119 Phase 2
37 Celiac Plexus Radiosurgery for Pain Management Unknown status NCT02356406 Phase 2
38 Efficacy Study of Acupuncture to Treat the Upper Abdominal Pain of Cancer Patients Unknown status NCT01913574 Phase 2
39 A Double-blind Placebo-controlled Study to Evaluate Larazotide Acetate for the Treatment of Celiac Disease Completed NCT01396213 Phase 2 Larazotide Acetate;placebo
40 Desensitising Celiac Disease Patients With the Human Hookworm Completed NCT01661933 Phase 1, Phase 2
41 Safety and Efficacy of Varying Methods of ALV003 Administration for the Treatment of Celiac Disease Completed NCT01255696 Phase 2
42 Cytokine Profile in Children With Celiac Disease Completed NCT02244047 Phase 1, Phase 2 Bifidobacterium breve;Placebo (for Bifidobacterium breve)
43 Randomized, Double-Blind, Placebo-Controlled Study of Larazotide Acetate in Subjects With Active Celiac Disease Completed NCT00620451 Phase 2 larazotide acetate;placebo
44 Safety and Efficacy of ALV003 for the Treatment of Celiac Disease Completed NCT00959114 Phase 2
45 A Phase II Study of CCX282-B in Patients With Celiac Disease Completed NCT00540657 Phase 2 CCX282-B;Placebo
46 A Study to Evaluate the Efficacy and Safety of AMG 714 in Adult Patients With Celiac Disease Completed NCT02637141 Phase 2
47 Safety of Prolonged Administration of Triticum Monococcum in Celiac Disease Completed NCT02220166 Phase 2
48 Effect of Aspergillus Niger Prolyl Endoprotease (AN-PEP) Enzyme on the Effects of Gluten Ingestion in Patients With Coeliac Disease Completed NCT00810654 Phase 1, Phase 2
49 Study of Enzyme Supplements to Treat Celiac Disease Completed NCT00962182 Phase 1, Phase 2 STAN1;Placebo enzyme;STAN1+gluten
50 Study to Assess the Efficacy of Larazotide Acetate for the Treatment of Celiac Disease Completed NCT00492960 Phase 2 larazotide acetate;placebo

Search NIH Clinical Center for Celiac Disease 1

Inferred drug relations via UMLS 73 / NDF-RT 51 :

Cell-based therapeutics:

LifeMap Discovery
Data from LifeMap, the Embryonic Development and Stem Cells Database
Read about Celiac Disease 1 cell therapies at LifeMap Discovery.
Stem-cell-based therapeutic approaches for Celiac Disease 1:
Regenerative ColoTherapy
Embryonic/Adult Cultured Cells Related to Celiac Disease 1:
Adipose-derived mesenchymal stem cells (family)
Peripheral blood-derived hematopoietic stem cells (family)

Cochrane evidence based reviews: celiac disease

Genetic Tests for Celiac Disease 1

Genetic tests related to Celiac Disease 1:

# Genetic test Affiliating Genes
1 Celiac Disease 29 HLA-DQA1 HLA-DQB1

Anatomical Context for Celiac Disease 1

MalaCards organs/tissues related to Celiac Disease 1:

Small Intestine, Testes, Thyroid, T Cells, Liver, Bone, Skin

The Foundational Model of Anatomy Ontology organs/tissues related to Celiac Disease 1:

Small Intestine To Gliadin

Publications for Celiac Disease 1

Articles related to Celiac Disease 1:

(show top 50) (show all 1606)
# Title Authors Year
The pre-treatment characteristics and evaluation of the effects of recombinant human growth hormone therapy in children with growth hormone deficiency and celiac disease or inflammatory bowel disease. ( 29736148 )
Celiac disease associated with aplastic anemia in a 6-year-old girl: a case report and review of the literature. ( 29361973 )
Prevalence of celiac disease in patients with Down syndrome: a meta-analysis. ( 29435186 )
A subset of patients with pemphigoid (herpes) gestationis has serological evidence of celiac disease. ( 29473148 )
Anti-transglutaminase 6 Antibody Development in Children With Celiac Disease Correlates With Duration of Gluten Exposure. ( 28542044 )
A locus at 7p14.3 predisposes to refractory celiac disease progression from celiac disease. ( 29787419 )
Clozapine Associated With Microscopic Colitis in the Setting of Biopsy-Proven Celiac Disease. ( 29424803 )
Colorectal Adenoma Risk Is Increased among Recently Diagnosed Adult Celiac Disease Patients. ( 29849594 )
Screening for autoimmune thyroiditis and celiac disease in minority children with type 1 diabetes. ( 29949512 )
Celiac Disease and Wheat Allergy: A Growing Association? ( 29847816 )
Celiac Disease in Children with Moderate-to-Severe Iron-deficiency Anemia. ( 29396932 )
When your patient's parent asks: "My child's alopecia areata is not getting better. Should he or she get tested for celiac disease?" ( 29797748 )
Features of Adult Autoimmune Enteropathy Compared With Refractory Celiac Disease. ( 29307846 )
Prevalence of celiac disease among pediatric patients with cryptogenic cirrhosis and effect of gluten-free-diet. ( 29948993 )
Spastic paraparesis revealing celiac disease. ( 29562387 )
The prevalence of celiac disease in adult Chinese patients with diarrhea predominant irritable bowel syndrome of China, a prospective, controlled, cohort study. ( 29451364 )
Splenic dysfunction from celiac disease resulting in severe babesiosis. ( 28286145 )
Association Between Early-Life Antibiotic Use and the Risk of Islet or Celiac Disease Autoimmunity. ( 29052687 )
Development of TaqMan probes targeting the four major celiac disease epitopes found in I+-gliadin sequences of spelt (Triticum aestivum ssp. spelta) and bread wheat (Triticum aestivum ssp. aestivum). ( 28912827 )
Screening for Celiac Disease: Recommendation Statement. ( 28925634 )
Splenic volume differentiates complicated and non-complicated celiac disease. ( 28507749 )
Salivary Gluten Degradation and Oral Microbial Profiles in Health and Celiac Disease. ( 28087531 )
Clinical and biological correlations in celiac disease in children: the prospective single experience of a romanian tertiary center: A case-control study (Strobe-Compliant study). ( 28514313 )
Celiac disease: a clinical review. ( 28078381 )
Optic neuritis in a patient with celiac disease. ( 28803640 )
The role of gluten consumption at an early age in celiac disease development: a further analysis of the prospective PreventCD cohort study. ( 28228423 )
Celiac disease in Saudi children. Evaluation of clinical features and diagnosis. ( 28889146 )
Trichotillomania in celiac disease patient refractory to iron replacement. ( 28779566 )
The DMT1 IVS4+44C>A polymorphism and the risk of iron deficiency anemia in children with celiac disease. ( 29023457 )
Migraine, Celiac Disease and Intestinal Microbiota. ( 28507424 )
[Assessment of an algorithm to identify paediatric-onset celiac disease cases through administrative healthcare databases]. ( 28627151 )
Prediction of esophageal and gastric histology by macroscopic diagnosis during upper endoscopy in pediatric celiac disease. ( 28216971 )
No Need for Routine Endoscopy in Children With Celiac Disease on a Gluten-free diet. ( 28489675 )
Nutritional Nightmare: Hypoparathyroidism Secondary to Celiac Disease. ( 28826689 )
Comprehensive Computational Analysis of GWAS Loci Identifies CCR2 as a Candidate gene for Celiac Disease Pathogenesis. ( 28059456 )
Potential role of the IL-33/ST2 axis in celiac disease. ( 26343805 )
Gluten-free diet is not recommended for people without celiac disease. ( 28468759 )
New Insights into the Pathogenesis of Celiac Disease. ( 28913337 )
Intestinal Production of Anti-Tissue Transglutaminase 2 Antibodies in Patients with Diagnosis Other Than Celiac Disease. ( 28934109 )
Whole exome sequencing of a consanguineous family identifies the possible modifying effect of a globally rare AK5 allelic variant in celiac disease development among Saudi patients. ( 28505210 )
Impact of type 1 diabetes mellitus and celiac disease on nutrition and quality of life. ( 28067892 )
Genetic predictors of celiac disease, lactose intolerance, and vitamin D function and presence of peptide morphins in urine of children with neurodevelopmental disorders. ( 28738753 )
The association between semaphorin 3A levels and gluten-free diet in patients with celiac disease. ( 28502679 )
HMGB1 as a new biomarker of celiac disease in children: AA multicenter study. ( 28359357 )
Association of Autoimmune Hepatitis and Celiac Disease: Role of Gluten-Free Diet in Reversing Liver Dysfunction. ( 28491884 )
Long term gluten consumption in adults without celiac disease and risk of coronary heart disease: prospective cohort study. ( 28465308 )
Cardiovascular involvement in celiac disease. ( 28932354 )
The eyes of children with celiac disease. ( 28087348 )
Retrospective evaluation of pregnant women with celiac disease. ( 28506952 )
Outcome of Referrals for Non-Responsive Celiac Disease in a Tertiary Center: Low Incidence of Refractory Celiac Disease in the Netherlands. ( 28125074 )

Variations for Celiac Disease 1

Expression for Celiac Disease 1

Search GEO for disease gene expression data for Celiac Disease 1.

Pathways for Celiac Disease 1

GO Terms for Celiac Disease 1

Cellular components related to Celiac Disease 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II protein complex GO:0042613 8.62 HLA-DQA1 HLA-DQB1

Biological processes related to Celiac Disease 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.77 CD79A CTLA4 HLA-DQA1 IRF1 PTPN22
2 regulation of innate immune response GO:0045088 9.4 IRF1 PTPN22
3 T cell costimulation GO:0031295 9.33 CTLA4 HLA-DQA1 HLA-DQB1
4 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II GO:0002504 9.32 HLA-DQA1 HLA-DQB1
5 hormone biosynthetic process GO:0042446 9.26 TG TPO
6 interferon-gamma-mediated signaling pathway GO:0060333 9.13 HLA-DQA1 HLA-DQB1 IRF1
7 negative regulation of regulatory T cell differentiation GO:0045590 8.62 CTLA4 IRF1

Molecular functions related to Celiac Disease 1 according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MHC class II receptor activity GO:0032395 8.62 HLA-DQA1 HLA-DQB1

Sources for Celiac Disease 1

9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
70 SNOMED-CT via Orphanet
72 Tocris
74 UMLS via Orphanet
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