CELIAC2
MCID: CLC045
MIFTS: 19

Celiac Disease 2 (CELIAC2)

Categories: Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Celiac Disease 2

MalaCards integrated aliases for Celiac Disease 2:

Name: Celiac Disease 2 57
Celiac Disease, Susceptibility to, 2 57 13
Gluten-Sensitive Enteropathy, Susceptibility to, 2 57
Gluten-Sensitive Enteropathy 2 57
Celiac2 57

Classifications:



External Ids:

MedGen 42 C1857846

Summaries for Celiac Disease 2

OMIM : 57 Celiac disease, also known as celiac sprue and gluten-sensitive enteropathy, is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins (summary by Farrell and Kelly, 2002). For additional information and a discussion of genetic heterogeneity of celiac disease, see 212750. (609754)

MalaCards based summary : Celiac Disease 2, also known as celiac disease, susceptibility to, 2, is related to celiac disease 1. An important gene associated with Celiac Disease 2 is CELIAC2 (Celiac Disease 2). The drugs Antibodies and Immunoglobulins have been mentioned in the context of this disorder. Affiliated tissues include small intestine and testes.

Related Diseases for Celiac Disease 2

Diseases in the Celiac Disease 1 family:

Celiac Disease 5 Celiac Disease 4
Celiac Disease 2 Celiac Disease 3
Celiac Disease 6 Celiac Disease 7
Celiac Disease 8 Celiac Disease 9
Celiac Disease 10 Celiac Disease 11
Celiac Disease 12 Celiac Disease 13

Diseases related to Celiac Disease 2 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 celiac disease 1 10.0

Symptoms & Phenotypes for Celiac Disease 2

Clinical features from OMIM:

609754

Drugs & Therapeutics for Celiac Disease 2

Drugs for Celiac Disease 2 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Antibodies
2 Immunoglobulins
3 Vaccines

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Prevention of Celiac Disease in Children at Genetic Risk - Optimized Introduction of Gluten and Follow-up of Immunization Unknown status NCT00617838
2 Low FODMAP (Fermentable Oligo-,di-,Mono-saccharides and Polyols) Versus Gluten-free Diet in Pediatric IBS Patients; a Cross-over Randomized Trial. Unknown status NCT02302703
3 The Role of Gut Permeability in Developing Celiac Disease and Non-Celiac Gluten Sensitivity Completed NCT02690532
4 The Role of Autoimmunity in Neurologic Complications of Celiac Disease Completed NCT00692861
5 Coeliac Disease in the Nord-Trøndelag Health Study (HUNT) Recruiting NCT04041622

Search NIH Clinical Center for Celiac Disease 2

Genetic Tests for Celiac Disease 2

Anatomical Context for Celiac Disease 2

MalaCards organs/tissues related to Celiac Disease 2:

41
Small Intestine, Testes

Publications for Celiac Disease 2

Articles related to Celiac Disease 2:

(show all 26)
# Title Authors PMID Year
1
A comprehensive screen for SNP associations on chromosome region 5q31-33 in Swedish/Norwegian celiac disease families. 8
17551518 2007
2
Meta and pooled analysis of European coeliac disease data. 8
14571266 2003
3
Celiac sprue. 8
11796853 2002
4
Genomewide linkage analysis of celiac disease in Finnish families. 8
11715113 2002
5
Genome-wide linkage analysis of Scandinavian affected sib-pairs supports presence of susceptibility loci for celiac disease on chromosomes 5 and 11. 8
11840196 2001
6
Existence of a genetic risk factor on chromosome 5q in Italian coeliac disease families. 8
11415521 2001
7
Genome search in celiac disease. 8
9497251 1998
8
Dermatitis Herpetiformis and Celiac Disease Increase the Risk of Bullous Pemphigoid. 38
30612975 2019
9
Epidemiological and genomic characterization of community-acquired Clostridium difficile infections. 38
30170546 2018
10
Autoantibodies to Dense Fine Speckles in Pediatric Diseases and Controls. 38
26472409 2015
11
[Significance of a method for determination of deamidated gliadin peptide in the diagnosis of celiac disease]. 38
24772506 2014
12
Pediatric Pseudotumor Cerebri Associated With Low Serum Levels of Vitamin A. 38
23364653 2013
13
Capsule Endoscopy in Patients with Implantable Electromedical Devices is Safe. 38
23710168 2013
14
The spectrum of celiac disease: epidemiology, clinical aspects and treatment. 38
20212505 2010
15
Clinical utility of serologic testing for celiac disease in ontario: an evidence-based analysis. 38
23074399 2010
16
Fine mapping of the CELIAC2 locus on chromosome 5q31-q33 in the Finnish and Hungarian populations. 38
19845895 2009
17
Mucosal atrophy in celiac disease: extent of involvement, correlation with clinical presentation, and response to treatment. 38
18096440 2008
18
Analysis of candidate genes on chromosomes 5q and 19p in celiac disease. 38
17667713 2007
19
A functional candidate screen for coeliac disease genes. 38
16835590 2006
20
Malabsorption syndrome due to various causes is associated with antroduodenal hypomotility. 38
16763331 2006
21
Chromosome 5q candidate genes in coeliac disease: genetic variation at IL4, IL5, IL9, IL13, IL17B and NR3C1. 38
15713213 2005
22
IL12B and IRF1 gene polymorphisms and susceptibility to celiac disease. 38
14675396 2003
23
Significance of unsuspected celiac disease detected at endoscopy. 38
10625798 2000
24
Antibodies to gliadin, endomysium, and tissue transglutaminase for the diagnosis of celiac disease. 38
10554125 1999
25
Celiac disease: parental knowledge and attitudes of dietary compliance. 38
2296499 1990
26
[Further investigations on the toxic effect of wheat flour in celiac disease. 2. Effect of enzymatic by-products of gliadin]. 38
13672521 1959

Variations for Celiac Disease 2

Expression for Celiac Disease 2

Search GEO for disease gene expression data for Celiac Disease 2.

Pathways for Celiac Disease 2

GO Terms for Celiac Disease 2

Sources for Celiac Disease 2

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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