CELIAC5
MCID: CLC046
MIFTS: 21

Celiac Disease 5 (CELIAC5)

Categories: Gastrointestinal diseases, Genetic diseases, Immune diseases, Rare diseases

Aliases & Classifications for Celiac Disease 5

MalaCards integrated aliases for Celiac Disease 5:

Name: Celiac Disease 5 57
Celiac Disease, Susceptibility to, 5 57 13
Gluten-Sensitive Enteropathy, Susceptibility to, 5 57
Gluten-Sensitive Enteropathy 5 57
Celiac5 57
Gses 57

Classifications:



External Ids:

OMIM® 57 607202
OMIM Phenotypic Series 57 PS212750
MedGen 41 C1846631

Summaries for Celiac Disease 5

OMIM® : 57 Celiac disease, also known as celiac sprue and gluten-sensitive enteropathy, is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins (summary by Farrell and Kelly, 2002). For additional information and a discussion of genetic heterogeneity of celiac disease, see 212750. (607202) (Updated 05-Mar-2021)

MalaCards based summary : Celiac Disease 5, also known as celiac disease, susceptibility to, 5, is related to celiac disease 1. An important gene associated with Celiac Disease 5 is CELIAC5 (Celiac Disease, Susceptibility To, 5). The drugs Grape and Quercetin have been mentioned in the context of this disorder. Affiliated tissues include small intestine, prostate and smooth muscle.

Related Diseases for Celiac Disease 5

Diseases in the Celiac Disease 1 family:

Celiac Disease 5 Celiac Disease 4
Celiac Disease 2 Celiac Disease 3
Celiac Disease 6 Celiac Disease 7
Celiac Disease 8 Celiac Disease 9
Celiac Disease 10 Celiac Disease 11
Celiac Disease 12 Celiac Disease 13

Diseases related to Celiac Disease 5 via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 celiac disease 1 9.9

Symptoms & Phenotypes for Celiac Disease 5

Clinical features from OMIM®:

607202 (Updated 05-Mar-2021)

Drugs & Therapeutics for Celiac Disease 5

Drugs for Celiac Disease 5 (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Grape Approved Phase 1
2
Quercetin Experimental, Investigational Phase 1 117-39-5 5280343
3
Resveratrol Investigational Phase 1 501-36-0 445154
4 Anthocyanidin Phase 1
5 Protective Agents Phase 1
6 Anti-Inflammatory Agents Phase 1
7 Analgesics, Non-Narcotic Phase 1
8 Antioxidants Phase 1
9 Anti-Inflammatory Agents, Non-Steroidal Phase 1
10 Antirheumatic Agents Phase 1
11 Analgesics Phase 1
12 Platelet Aggregation Inhibitors Phase 1
13 Grape Seed Extract
14 Insulin, Globin Zinc
15 insulin

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Grape Seeds Extract Gel as an Adjunct to Scaling and Root Planing for the Treatment of Chronic Periodontitis: A Pilot Clinical Study Completed NCT02767115 Phase 2
2 GRAPe Seed Extract and Ventriculovascular Investigation in Normal Ejection-Fraction Heart Failure Completed NCT01185067 Phase 1 grape seed extract (MegaNatural BP, Polyphenolics, Inc.)
3 BDPP Treatment for Mild Cognitive Impairment (MCI) and Prediabetes or Type 2 Diabetes Mellitus (T2DM) Recruiting NCT02502253 Phase 1 grape seed polyphenolic extract, resveratrol
4 Dose-dependent Effect of Grape Seed Extract (GSE) on Glucose Control in People With Impaired Glucose Tolerance Completed NCT02254317
5 Effect of a Grape Seed Extract (GSE) on Insulin Resistance Completed NCT01889368
6 Clinical Practice Guideline With Core Stabilization and Strengthening Exercise Programs for Low Back Pain With Clinical Lumbar Instability Completed NCT02895828
7 Effects of Chronic Dietary Grape Seed Extract Supplementation on Aortic Stiffness and Hemodynamic Responses in Obese/Overweight Males During Submaximal Exercise Completed NCT04465110
8 Early Integration of Supportive Care Into Standard Oncology Care for Metastatic Uveal Melanoma Patients Recruiting NCT04728113
9 A Phase 2 Study of Grape Seed Extract (GSE) Product in Asymptomatic Non-Metastatic Prostate Cancer Patients With Rising Prostate Specific Antigen (PSA) Active, not recruiting NCT03087903
10 Effect of Grape Seed Extract on Modulation of Oxidative Stress/ Inflammation/ Insulin Sensitivity Induced by High Fat-carbohydrate Meal in Healthy Human Subjects Active, not recruiting NCT01995643

Search NIH Clinical Center for Celiac Disease 5

Genetic Tests for Celiac Disease 5

Anatomical Context for Celiac Disease 5

MalaCards organs/tissues related to Celiac Disease 5:

40
Small Intestine, Prostate, Smooth Muscle, Liver

Publications for Celiac Disease 5

Articles related to Celiac Disease 5:

(show all 14)
# Title Authors PMID Year
1
A new locus for coeliac disease mapped to chromosome 15 in a population isolate. 57
12136234 2002
2
Celiac sprue. 57
11796853 2002
3
Association Between Severity of Diabetic Ketoacidosis at Diagnosis and Multiple Autoimmunity in Children With Type 1 Diabetes Mellitus: A Study From a Greek Tertiary Centre. 61
32800761 2021
4
Pediatric autoimmune liver disease and extra-hepatic immune-mediated comorbidities. 61
30166220 2019
5
Internalizing the threat of risk--a qualitative study about adolescents' experience living with screening-detected celiac disease 5 years after diagnosis. 61
24915870 2014
6
A community cross-sectional survey of medical problems in 440 children with Down syndrome in New York State. 61
24367984 2014
7
The diagnosis and outcomes of persistent diarrhea in infants aged 0-24 months--a Turkish cohort study. 61
21805416 2011
8
Role of autoimmune gastritis, Helicobacter pylori and celiac disease in refractory or unexplained iron deficiency anemia. 61
15921373 2005
9
Diagnostic accuracy of fecal calprotectin assay in distinguishing organic causes of chronic diarrhea from irritable bowel syndrome: a prospective study in adults and children. 61
12765980 2003
10
Histologic follow-up of people with celiac disease on a gluten-free diet: slow and incomplete recovery. 61
12219789 2002
11
Association of subepithelial deposition of activated complement and immunoglobulin G and M response to gluten in celiac disease. 61
1537512 1992
12
Postheparin plasma diamine oxidase in subjects with small bowel disease. Diagnostic efficiency of a simplified test. 61
3144470 1988
13
[Antibodies against smooth muscle in the detection and follow-up of the celiac disease patient]. 61
3505399 1987
14
In vitro digestion of cow's milk proteins by duodenal juice from infants with various gastrointestinal disorders. 61
6897898 1982

Variations for Celiac Disease 5

Expression for Celiac Disease 5

Search GEO for disease gene expression data for Celiac Disease 5.

Pathways for Celiac Disease 5

GO Terms for Celiac Disease 5

Sources for Celiac Disease 5

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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