Cell Type Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CLL012 MIFTS: 34	Cell Type Benign Neoplasm Categories: Cancer diseases
Genes Tissues Related diseases Pathways Expand all tables

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Aliases & Classifications for Cell Type Benign Neoplasm

MalaCards integrated aliases for Cell Type Benign Neoplasm:

Name: Cell Type Benign Neoplasm ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060084

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Summaries for Cell Type Benign Neoplasm

Disease Ontology : ¹² A benign neoplasm that is classified by the type of cell or tissue from which it is derived.

MalaCards based summary : Cell Type Benign Neoplasm is related to adenoma and lipomatosis, multiple. An important gene associated with Cell Type Benign Neoplasm is POMC (Proopiomelanocortin), and among its related pathways/superpathways are G-Beta Gamma Signaling and fMLP Pathway. Affiliated tissues include pituitary, thyroid and lung, and related phenotypes are Decreased viability in esophageal squamous lineage and Reduced mammosphere formation

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Related Diseases for Cell Type Benign Neoplasm

Diseases related to Cell Type Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)

#	Related Disease	Score	Top Affiliating Genes
1	adenoma	30.8	AIP APC CTNNB1 CYP11B2 GNAS IGF1
2	lipomatosis, multiple	11.1
3	gonadoblastoma	11.1
4	ameloblastoma	11.1
5	leiomyoma	11.1
6	chondroma	11.1
7	benign mesothelioma	11.1
8	adenofibroma	11.1
9	angiomyolipoma	11.1
10	ganglioglioma	11.1
11	adenohypophysitis	10.6	POMC PRL
12	schimmelpenning-feuerstein-mims syndrome	10.6	HRAS KRAS
13	paronychia	10.6	HRAS KRAS
14	gallbladder adenoma	10.6	CTNNB1 HRAS
15	pancreatic somatostatinoma	10.6	MEN1 SST
16	aldosterone-producing adenoma	10.6	CYP11B2 KCNJ5
17	bronchus adenoma	10.6	POMC SST
18	attenuated familial adenomatous polyposis	10.6	APC MUTYH
19	bronchial adenomas/carcinoids childhood	10.6	POMC SST
20	respiratory system disease	10.6	HRAS KRAS TP53
21	primary hyperparathyroidism	10.6	MEN1 PRL PTH
22	suppression of tumorigenicity 12	10.6	CTNNB1 HRAS TP53
23	silent pituitary adenoma	10.6	AIP MEN1
24	null pituitary adenoma	10.6	AIP MEN1
25	parathyroid transitional clear cell adenoma	10.6	MEN1 PTH
26	chiasmal syndrome	10.5	POMC PRL SST
27	sigmoid neoplasm	10.5	HRAS KRAS
28	pituitary carcinoma	10.5	POMC PRL SST
29	insulin-like growth factor i	10.5	IGF1 PRL SST
30	prolactin producing pituitary tumor	10.5	PRL SST TP53
31	nelson syndrome	10.5	POMC PRL SST
32	thymic neuroendocrine tumor	10.5	HRAS MEN1
33	tsh producing pituitary tumor	10.5	POMC PRL SST
34	secondary hypertrophic osteoarthropathy	10.5	HRAS KRAS POMC
35	nasal cavity adenocarcinoma	10.5	HRAS KRAS TP53
36	pituitary apoplexy	10.5	AIP POMC PRL
37	acidophil adenoma	10.5	IGF1 POMC SST
38	biliary papillomatosis	10.5	HRAS KRAS TP53
39	chromophobe adenoma	10.5	POMC PRL TP53
40	empty sella syndrome	10.5	IGF1 POMC PRL
41	sheehan syndrome	10.5	IGF1 POMC PRL
42	clear cell adenoma	10.5	CTNNB1 MEN1 PTH
43	scleredema adultorum	10.5	POMC PTH
44	liver angiosarcoma	10.5	HRAS KRAS TP53
45	pituitary-dependent cushing's disease	10.5	POMC PRL SST
46	ampulla of vater cancer	10.5	HRAS KRAS TP53
47	ectopic cushing syndrome	10.5	MEN1 POMC SST
48	ovary adenocarcinoma	10.5	HRAS KRAS TP53
49	bile duct adenocarcinoma	10.5	HRAS KRAS TP53
50	hypothyroidism, congenital, nongoitrous, 4	10.5	IGF1 POMC PRL

Graphical network of the top 20 diseases related to Cell Type Benign Neoplasm:

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Symptoms & Phenotypes for Cell Type Benign Neoplasm

GenomeRNAi Phenotypes related to Cell Type Benign Neoplasm according to GeneCards Suite gene sharing:

²⁷

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased viability in esophageal squamous lineage	GR00235-A	9.65	APC CTNNB1 GNAS HRAS KCNJ5 KRAS
2	Reduced mammosphere formation	GR00396-S	9.28	FH GNAS HRAS IGF1 KCNJ5 KRAS

MGI Mouse Phenotypes related to Cell Type Benign Neoplasm:

⁴⁷ (show all 23)

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	homeostasis/metabolism	MP:0005376	10.5	AIP APC CTNNB1 CYP11B2 FH GNAS
2	cardiovascular system	MP:0005385	10.46	AIP APC CTNNB1 CYP11B2 GNAS HRAS
3	endocrine/exocrine gland	MP:0005379	10.43	AIP APC CTNNB1 CYP11B2 GNAS HRAS
4	cellular	MP:0005384	10.42	AIP APC CTNNB1 FH GNAS IGF1
5	growth/size/body region	MP:0005378	10.42	AIP APC CTNNB1 CYP11B2 GNAS HRAS
6	immune system	MP:0005387	10.38	APC CTNNB1 CYP11B2 GNAS IGF1 KRAS
7	mortality/aging	MP:0010768	10.38	AIP APC CTNNB1 FH GNAS HRAS
8	hematopoietic system	MP:0005397	10.3	APC CTNNB1 CYP11B2 GNAS IGF1 KRAS
9	integument	MP:0010771	10.26	AIP APC CTNNB1 GNAS HRAS IGF1
10	neoplasm	MP:0002006	10.25	AIP APC CTNNB1 GNAS HRAS IGF1
11	nervous system	MP:0003631	10.25	APC CTNNB1 CYP11B2 GNAS HRAS IGF1
12	craniofacial	MP:0005382	10.2	APC CTNNB1 GNAS HRAS KRAS MEN1
13	digestive/alimentary	MP:0005381	10.19	APC CTNNB1 HRAS KRAS MEN1 MLH1
14	liver/biliary system	MP:0005370	10.19	AIP APC CTNNB1 CYP11B2 GNAS KRAS
15	muscle	MP:0005369	10.06	APC CTNNB1 GNAS IGF1 KRAS MEN1
16	limbs/digits/tail	MP:0005371	10.05	APC CTNNB1 GNAS IGF1 KRAS PTH
17	hearing/vestibular/ear	MP:0005377	10.04	APC CTNNB1 GNAS IGF1 KRAS TP53
18	normal	MP:0002873	9.97	APC CTNNB1 GNAS HRAS IGF1 KRAS
19	no phenotypic analysis	MP:0003012	9.91	CTNNB1 GNAS HRAS KRAS POMC SST
20	renal/urinary system	MP:0005367	9.9	APC CTNNB1 CYP11B2 FH GNAS HRAS
21	pigmentation	MP:0001186	9.65	APC CTNNB1 KRAS POMC TP53
22	reproductive system	MP:0005389	9.65	APC CTNNB1 CYP11B2 IGF1 KRAS MEN1
23	skeleton	MP:0005390	9.28	APC CTNNB1 GNAS HRAS IGF1 KRAS

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Drugs & Therapeutics for Cell Type Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Cell Type Benign Neoplasm

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Genetic Tests for Cell Type Benign Neoplasm

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Anatomical Context for Cell Type Benign Neoplasm

MalaCards organs/tissues related to Cell Type Benign Neoplasm:

⁴²

Pituitary, Thyroid, Lung, Colon, Breast, Ovary, Pancreas

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Publications for Cell Type Benign Neoplasm

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Genes for Cell Type Benign Neoplasm

Genes related to Cell Type Benign Neoplasm (0 elite genes):

(show all 35)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	POMC	Proopiomelanocortin	Protein Coding	18.97	DISEASES inferred ¹⁵
2	PRL	Prolactin	Protein Coding	18.47	DISEASES inferred ¹⁵
3	PTH	Parathyroid Hormone	Protein Coding	18.34	DISEASES inferred ¹⁵
4	TP53	Tumor Protein P53	Protein Coding	18.1	DISEASES inferred ¹⁵
5	HRAS	HRas Proto-Oncogene, GTPase	Protein Coding	17.93	DISEASES inferred ¹⁵
6	KRAS	KRAS Proto-Oncogene, GTPase	Protein Coding	17.9	DISEASES inferred ¹⁵
7	SST	Somatostatin	Protein Coding	17.89	DISEASES inferred ¹⁵
8	CTNNB1	Catenin Beta 1	Protein Coding	17.87	DISEASES inferred ¹⁵
9	FH	Fumarate Hydratase	Protein Coding	17.73	DISEASES inferred ¹⁵
10	MEN1	Menin 1	Protein Coding	17.72	DISEASES inferred ¹⁵
11	KCNJ5	Potassium Voltage-Gated Channel Subfamily J Member 5	Protein Coding	17.41	DISEASES inferred ¹⁵
12	MUTYH	MutY DNA Glycosylase	Protein Coding	17.33	DISEASES inferred ¹⁵
13	AIP	Aryl Hydrocarbon Receptor Interacting Protein	Protein Coding	17.33	DISEASES inferred ¹⁵
14	IGF1	Insulin Like Growth Factor 1	Protein Coding	17.33	DISEASES inferred ¹⁵
15	CYP11B2	Cytochrome P450 Family 11 Subfamily B Member 2	Protein Coding	17.24	DISEASES inferred ¹⁵
16	REN	Renin	Protein Coding	17.15	DISEASES inferred ¹⁵
17	MLH1	MutL Homolog 1	Protein Coding	17.12	DISEASES inferred ¹⁵
18	GNAS	GNAS Complex Locus	Protein Coding	17.11	DISEASES inferred ¹⁵
19	APC	APC Regulator Of WNT Signaling Pathway	Protein Coding	17.1	DISEASES inferred ¹⁵
20	SERPINA3	Serpin Family A Member 3	Protein Coding	16.92	DISEASES inferred ¹⁵ ¹⁵
21	TRH	Thyrotropin Releasing Hormone	Protein Coding	6.91	DISEASES inferred ¹⁵
22	SSTR5	Somatostatin Receptor 5	Protein Coding	6.89	DISEASES inferred ¹⁵
23	SSTR2	Somatostatin Receptor 2	Protein Coding	6.86	DISEASES inferred ¹⁵
24	KRT7	Keratin 7	Protein Coding	6.86	DISEASES inferred ¹⁵
25	HMGA2	High Mobility Group AT-Hook 2	Protein Coding	6.83	DISEASES inferred ¹⁵
26	CDC73	Cell Division Cycle 73	Protein Coding	6.83	DISEASES inferred ¹⁵
27	CD34	CD34 Molecule	Protein Coding	6.82	DISEASES inferred ¹⁵
28	CDKN2A	Cyclin Dependent Kinase Inhibitor 2A	Protein Coding	6.8	DISEASES inferred ¹⁵
29	PLAG1	PLAG1 Zinc Finger	Protein Coding	6.79	DISEASES inferred ¹⁵
30	PTGS2	Prostaglandin-Endoperoxide Synthase 2	Protein Coding	6.76	DISEASES inferred ¹⁵
31	CEACAM5	Carcinoembryonic Antigen Related Cell Adhesion Molecule 5	Protein Coding	6.73	DISEASES inferred ¹⁵
32	SYP	Synaptophysin	Protein Coding	6.72	DISEASES inferred ¹⁵
33	MUC6	Mucin 6, Oligomeric Mucus/Gel-Forming	Protein Coding	6.66	DISEASES inferred ¹⁵
34	CRH	Corticotropin Releasing Hormone	Protein Coding	6.65	DISEASES inferred ¹⁵
35	CCND1	Cyclin D1	Protein Coding	6.65	DISEASES inferred ¹⁵

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Variations for Cell Type Benign Neoplasm

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Expression for Cell Type Benign Neoplasm

Search GEO for disease gene expression data for Cell Type Benign Neoplasm.

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Pathways for Cell Type Benign Neoplasm

Pathways related to Cell Type Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 42)

#	Super pathways	Score	Top Affiliating Genes
1	G-Beta Gamma Signaling ⁶⁵ Show member pathways CRHR Pathway ⁶⁵ GHRH Signaling ⁶⁵ Hedgehog Signaling in Mammals ⁶⁵ Relaxin Pathway ⁶⁵ Signaling in Gap Junctions ⁶⁵	12.96	CTNNB1 GNAS HRAS KCNJ5 KRAS POMC
2	fMLP Pathway ⁶⁵ Show member pathways Alpha-Adrenergic Signaling ⁶⁵ CCR3 Pathway in Eosinophils ⁶⁵ CXCR4 Pathway ⁶⁵ Huntington's Disease Pathway ⁶⁵ Internalin Pathway ⁶⁵ Signal transduction Activation of PKC via G-Protein coupled receptor ²³ VEGF and S-1P Signaling ⁶⁵	12.95	CTNNB1 GNAS HRAS IGF1 KRAS TP53
3	PI3K-Akt signaling pathway ³⁸ Show member pathways Human papillomavirus infection ³⁸	12.76	APC CTNNB1 GNAS HRAS IGF1 KRAS
4	Endometrial cancer ³⁸ Show member pathways Acute myeloid leukemia ³⁸ Binding of TCF/LEF-CTNNB1 to target gene promoters ⁶⁷ Chronic myeloid leukemia ³⁸ Colorectal cancer ³⁸ Pancreatic cancer ³⁸ Prostate cancer ³⁸ Signal transduction PTEN pathway ²³ Thyroid cancer ³⁸	12.75	APC CTNNB1 HRAS IGF1 KRAS MLH1
5	Ras signaling pathway ³⁸ Show member pathways Rap1 signaling pathway ³⁸	12.67	CTNNB1 GNAS HRAS IGF1 KRAS
6	Development HGF signaling pathway ²³ Show member pathways Apoptosis and survival Anti-apoptotic action of membrane-bound ESR1 ²³ Apoptosis and survival NGF signaling pathway ²³ Apoptosis and survival Role of CDK5 in neuronal death and survival ²³ Development Neurotrophin family signaling ²³ MET activates PTPN11 ⁶⁷ MET activates STAT3 ⁶⁷ Neurotrophin signaling pathway ³⁸ Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) ¹ Signaling of Hepatocyte Growth Factor Receptor ¹	12.65	APC CTNNB1 HRAS KRAS TP53
7	Glioma ³⁸ Show member pathways Endocrine resistance ³⁸ Melanoma ³⁸ Non-small cell lung cancer ³⁸ Signaling Pathways in Glioblastoma ¹	12.64	GNAS HRAS IGF1 KRAS TP53
8	Gastric cancer ³⁸ Show member pathways Breast cancer ³⁸ Hepatocellular carcinoma ³⁸	12.61	APC CTNNB1 HRAS IGF1 KRAS MLH1
9	Development Endothelin-1/EDNRA signaling ²³ Show member pathways Cytoskeleton remodeling FAK signaling ²³ Development Endothelin-1/EDNRA transactivation of EGFR ²³ GnRH signaling pathway ³⁸ Inflammatory mediator regulation of TRP channels ³⁸	12.6	CTNNB1 GNAS HRAS IGF1 KRAS
10	mTOR signaling pathway (KEGG) ³⁸ Show member pathways mTOR Signaling Pathway ⁶⁶	12.43	APC HRAS IGF1 KRAS TP53
11	WNT Signaling ⁶⁵	12.39	APC CTNNB1 GNAS TP53
12	Apoptosis Pathway ⁷³ Show member pathways Akt Pathway ⁷³ NF-kappaB Pathway ⁷³	12.38	CTNNB1 HRAS KRAS TP53
13	G-protein signaling RAC1 in cellular process ²³ Show member pathways CDC42 signaling events ¹ Cytoskeleton remodeling CDC42 in cellular processes ²³ RAC1 signaling pathway ¹	12.35	APC CTNNB1 HRAS IGF1 KRAS
14	Human T-cell leukemia virus 1 infection ³⁸	12.26	APC CTNNB1 HRAS KRAS TP53
15	Proteoglycans in cancer ³⁸	12.2	CTNNB1 HRAS IGF1 KRAS TP53
16	Peptide hormone metabolism ⁶⁷ Show member pathways Glycoprotein hormones ⁶⁷ Insulin processing ⁶⁷ Metabolism of Angiotensinogen to Angiotensins ⁶⁷ Peptide hormone biosynthesis ⁶⁷ Synthesis, secretion, and deacylation of Ghrelin ⁶⁷	12.16	CTNNB1 IGF1 POMC REN
17	Longevity regulating pathway ³⁸ Show member pathways Longevity regulating pathway - multiple species ³⁸	12.06	HRAS IGF1 KRAS TP53
18	Pathways in cancer ³⁸	12	APC CTNNB1 FH GNAS HRAS IGF1
19	Signaling pathways regulating pluripotency of stem cells ³⁸	11.97	APC CTNNB1 HRAS IGF1 KRAS
20	G12-G13 in Cellular Signaling ⁶⁵	11.95	APC CTNNB1 HRAS KRAS
21	Thyroid hormone signaling pathway ³⁸	11.91	CTNNB1 HRAS KRAS TP53
22	Serotonergic synapse ³⁸	11.9	GNAS HRAS KCNJ5 KRAS
23	Colorectal Cancer Metastasis ⁶⁵	11.85	APC CTNNB1 GNAS KRAS MLH1 TP53
24	Corticotropin-releasing hormone signaling pathway ¹	11.83	CTNNB1 GNAS POMC
25	DNA Damage Response (only ATM dependent) ¹	11.83	APC CTNNB1 HRAS KRAS TP53
26	Gap junction ³⁸	11.79	GNAS HRAS KRAS
27	Glucocorticoid receptor regulatory network ¹	11.75	POMC PRL TP53
28	Bladder cancer ¹ ³⁸	11.69	HRAS KRAS TP53
29	Central carbon metabolism in cancer ³⁸	11.63	HRAS KRAS TP53
30	Mitophagy - animal ³⁸	11.63	HRAS KRAS TP53
31	Long-term depression ³⁸	11.56	GNAS HRAS IGF1 KRAS
32	DNA damage_Role of Brca1 and Brca2 in DNA repair ²³	11.51	HRAS KRAS MLH1 TP53
33	Glioblastoma Multiforme ⁶⁵	11.48	APC CTNNB1 HRAS IGF1 KRAS TP53
34	Aryl Hydrocarbon Receptor ¹	11.45	AIP HRAS KRAS
35	Deactivation of the beta-catenin transactivating complex ⁶⁷	11.39	APC CTNNB1 MEN1
36	G-protein signaling_Cross-talk between Ras-family GTPases ²³	11.35	GNAS HRAS IGF1 KRAS
37	Transcription_Transcription factor Tubby signaling pathways ²³	11.27	HRAS KRAS TP53
38	EGFR Transactivation by Gastrin ⁶⁷ Show member pathways EGFR-dependent Endothelin signaling events ¹ SHC-related events triggered by IGF1R ⁶⁷	11.1	HRAS IGF1 KRAS
39	Extracellular vesicle-mediated signaling in recipient cells ¹	11.03	APC CTNNB1 HRAS KRAS
40	BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation ¹	10.79	CTNNB1 SST
41	p38MAPK events ⁶⁷	10.79	HRAS KRAS
42	RHO GTPases activate IQGAPs ⁶⁷	10.79	CTNNB1 MEN1

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GO Terms for Cell Type Benign Neoplasm

Cellular components related to Cell Type Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	beta-catenin destruction complex	GO:0030877	8.96	APC CTNNB1
2	Wnt signalosome	GO:1990909	8.62	APC CTNNB1

Biological processes related to Cell Type Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 17)

#	Name	GO ID	Score	Top Affiliating Genes
1	cellular response to DNA damage stimulus	GO:0006974	9.96	APC MEN1 MLH1 MUTYH TP53
2	regulation of signaling receptor activity	GO:0010469	9.95	IGF1 POMC PRL PTH SST
3	positive regulation of gene expression	GO:0010628	9.93	CTNNB1 HRAS IGF1 KRAS TP53
4	cell proliferation	GO:0008283	9.76	CTNNB1 HRAS IGF1 TP53
5	positive regulation of osteoblast differentiation	GO:0045669	9.67	CTNNB1 GNAS IGF1
6	negative regulation of cell proliferation	GO:0008285	9.63	APC CTNNB1 HRAS MEN1 SST TP53
7	skeletal system development	GO:0001501	9.62	CTNNB1 GNAS IGF1 PTH
8	negative regulation of telomerase activity	GO:0051974	9.57	MEN1 TP53
9	positive regulation of epithelial cell proliferation	GO:0050679	9.52	HRAS IGF1
10	response to isolation stress	GO:0035900	9.48	HRAS KRAS
11	hair follicle placode formation	GO:0060789	9.43	CTNNB1 GNAS
12	homeostasis of number of cells within a tissue	GO:0048873	9.43	FH KRAS PTH
13	hormone-mediated apoptotic signaling pathway	GO:0008628	9.4	PTH SST
14	response to parathyroid hormone	GO:0071107	9.37	GNAS PTH
15	Ras protein signal transduction	GO:0007265	9.26	HRAS IGF1 KRAS TP53
16	response to drug	GO:0042493	9.02	CTNNB1 GNAS PTH REN SST
17	positive regulation of transcription by RNA polymerase II	GO:0045944	10.05	CTNNB1 HRAS IGF1 MEN1 POMC PTH

Molecular functions related to Cell Type Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	MutSalpha complex binding	GO:0032407	9.16	MLH1 MUTYH
2	insulin-like growth factor receptor binding	GO:0005159	9.13	GNAS IGF1 REN
3	hormone activity	GO:0005179	9.02	IGF1 POMC PRL PTH SST

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