MCID: CLL012
MIFTS: 36

Cell Type Benign Neoplasm

Categories: Cancer diseases, Genetic diseases, Rare diseases, Respiratory diseases, Skin diseases

Aliases & Classifications for Cell Type Benign Neoplasm

MalaCards integrated aliases for Cell Type Benign Neoplasm:

Name: Cell Type Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060084

Summaries for Cell Type Benign Neoplasm

Disease Ontology : 12 A benign neoplasm that is classified by the type of cell or tissue from which it is derived.

MalaCards based summary : Cell Type Benign Neoplasm is related to hemangioma and adenoma. An important gene associated with Cell Type Benign Neoplasm is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Affiliated tissues include lung, skin and liver, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

Related Diseases for Cell Type Benign Neoplasm

Diseases in the Small Cell Carcinoma family:

Basal Cell Carcinoma 1 Basal Cell Carcinoma 2
Basal Cell Carcinoma 3 Basal Cell Carcinoma 4
Basal Cell Carcinoma 5 Basal Cell Carcinoma 6
Basal Cell Carcinoma 7 Cell Type Benign Neoplasm
Basal Cell Carcinoma Large Cell Carcinoma
Basal Cell Carcinoma, Multiple

Diseases related to Cell Type Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 184)
# Related Disease Score Top Affiliating Genes
1 hemangioma 32.0 CCM2 CD34 KRAS KRIT1
2 adenoma 31.5 AIP CTNNB1 IGF1 KCNJ5 KRAS MEN1
3 lipomatosis, multiple 11.1
4 gonadoblastoma 11.1
5 ameloblastoma 11.1
6 benign glioma 11.1
7 leiomyoma 11.1
8 chondroma 11.1
9 benign mesothelioma 11.1
10 adenofibroma 11.1
11 angiomyolipoma 11.1
12 ganglioglioma 11.1
13 pancreatic somatostatinoma 10.4 MEN1 SST
14 gallbladder adenoma 10.4 CTNNB1 HRAS
15 schimmelpenning-feuerstein-mims syndrome 10.4 HRAS KRAS
16 paronychia 10.4 HRAS KRAS
17 duodenal somatostatinoma 10.4 INS SST
18 postgastrectomy syndrome 10.4 INS SST
19 postural hypotension 10.4 INS SST
20 pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities 10.4 IGF1 INS
21 invasive malignant thymoma 10.4 CD34 PTH
22 meninges sarcoma 10.4 CD34 TP53
23 psammomatous meningioma 10.4 CD34 CTNNB1
24 primary hyperparathyroidism 10.4 MEN1 PRL PTH
25 bronchus adenoma 10.4 POMC SST
26 bronchial adenomas/carcinoids childhood 10.4 POMC SST
27 parathyroid transitional clear cell adenoma 10.4 MEN1 PTH
28 silent pituitary adenoma 10.4 AIP MEN1
29 null pituitary adenoma 10.4 AIP MEN1
30 chiasmal syndrome 10.4 POMC PRL SST
31 insulinoma 10.4 INS MEN1 SST
32 pituitary carcinoma 10.4 POMC PRL SST
33 suppression of tumorigenicity 12 10.4 CTNNB1 HRAS TP53
34 respiratory system disease 10.4 HRAS KRAS TP53
35 nelson syndrome 10.4 POMC PRL SST
36 acidophil adenoma 10.4 IGF1 POMC SST
37 prolactin producing pituitary tumor 10.4 PRL SST TP53
38 scleredema adultorum 10.4 INS POMC PTH
39 tsh producing pituitary tumor 10.4 POMC PRL SST
40 clear cell adenoma 10.4 CTNNB1 MEN1 PTH
41 thymic neuroendocrine tumor 10.4 HRAS MEN1
42 periampullary adenoma 10.4 HRAS KRAS SST
43 sigmoid neoplasm 10.3 HRAS KRAS
44 pancreatic endocrine carcinoma 10.3 INS POMC SST
45 secondary hypertrophic osteoarthropathy 10.3 HRAS KRAS POMC
46 adenohypophysitis 10.3 POMC PRL TRH
47 ectopic cushing syndrome 10.3 MEN1 POMC SST
48 pineal region choriocarcinoma 10.3 CD34 IGF1
49 duodenal disease 10.3 KRAS MEN1 SST
50 nasal cavity adenocarcinoma 10.3 HRAS KRAS TP53

Graphical network of the top 20 diseases related to Cell Type Benign Neoplasm:



Diseases related to Cell Type Benign Neoplasm

Symptoms & Phenotypes for Cell Type Benign Neoplasm

GenomeRNAi Phenotypes related to Cell Type Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.28 CD34 FH HRAS IGF1 KCNJ5 KRAS

MGI Mouse Phenotypes related to Cell Type Benign Neoplasm:

46 (show all 17)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.45 AIP CCM2 CD34 CTNNB1 FH HRAS
2 cardiovascular system MP:0005385 10.41 AIP CCM2 CTNNB1 HRAS IGF1 INS
3 cellular MP:0005384 10.4 AIP CCM2 CD34 CTNNB1 FH IGF1
4 growth/size/body region MP:0005378 10.39 AIP CCM2 CTNNB1 HRAS IGF1 INS
5 mortality/aging MP:0010768 10.31 AIP CCM2 CTNNB1 FH HRAS IGF1
6 endocrine/exocrine gland MP:0005379 10.3 AIP CTNNB1 HRAS IGF1 INS KRAS
7 immune system MP:0005387 10.29 CCM2 CD34 CTNNB1 IGF1 INS KRAS
8 integument MP:0010771 10.27 AIP CCM2 CD34 CTNNB1 HRAS IGF1
9 embryo MP:0005380 10.19 AIP CCM2 CTNNB1 INS KRAS KRIT1
10 craniofacial MP:0005382 10.15 CCM2 CTNNB1 HRAS KRAS KRIT1 MEN1
11 neoplasm MP:0002006 10.13 AIP CD34 CTNNB1 HRAS IGF1 KRAS
12 nervous system MP:0003631 10.13 CCM2 CTNNB1 HRAS IGF1 INS KRAS
13 liver/biliary system MP:0005370 10.03 AIP CTNNB1 INS KRAS MEN1 POMC
14 muscle MP:0005369 10.02 CCM2 CTNNB1 IGF1 INS KRAS KRIT1
15 no phenotypic analysis MP:0003012 9.76 CTNNB1 HRAS INS KRAS POMC SST
16 normal MP:0002873 9.61 CCM2 CTNNB1 HRAS IGF1 INS KRAS
17 renal/urinary system MP:0005367 9.28 CTNNB1 FH HRAS IGF1 INS KRAS

Drugs & Therapeutics for Cell Type Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Cell Type Benign Neoplasm

Genetic Tests for Cell Type Benign Neoplasm

Anatomical Context for Cell Type Benign Neoplasm

MalaCards organs/tissues related to Cell Type Benign Neoplasm:

41
Lung, Skin, Liver, Bone, Colon, Thyroid, Pineal

Publications for Cell Type Benign Neoplasm

Variations for Cell Type Benign Neoplasm

Expression for Cell Type Benign Neoplasm

Search GEO for disease gene expression data for Cell Type Benign Neoplasm.

Pathways for Cell Type Benign Neoplasm

Pathways related to Cell Type Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 35)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.78 CTNNB1 HRAS IGF1 INS KRAS TP53
2 12.73 CTNNB1 FH HRAS IGF1 KRAS TP53
3
Show member pathways
12.71 CTNNB1 HRAS IGF1 INS KRAS PRL
4 12.7 HRAS IGF1 INS KRAS TP53
5
Show member pathways
12.69 CTNNB1 HRAS IGF1 KRAS TP53
6
Show member pathways
12.52 CTNNB1 HRAS IGF1 INS KRAS KRIT1
7
Show member pathways
12.41 HRAS IGF1 INS KRAS TP53
8
Show member pathways
12.37 HRAS IGF1 INS TP53
9
Show member pathways
12.37 CTNNB1 HRAS KRAS TP53
10 12.35 CTNNB1 HRAS KRAS TP53
11
Show member pathways
12.17 CTNNB1 IGF1 INS POMC
12 12.03 CTNNB1 HRAS IGF1 KRAS
13
Show member pathways
12.02 HRAS IGF1 INS KRAS
14
Show member pathways
11.99 HRAS INS KRAS TP53
15 11.96 CTNNB1 HRAS IGF1 KRAS TP53
16 11.89 CTNNB1 HRAS KRAS TP53
17 11.87 CTNNB1 HRAS KRAS TP53
18 11.78 HRAS IGF1 INS TP53
19 11.73 POMC PRL TP53
20
Show member pathways
11.73 HRAS IGF1 INS KRAS TP53
21 11.68 HRAS KRAS TP53
22 11.61 HRAS KRAS TP53
23 11.61 HRAS KRAS TP53
24 11.57 HRAS IGF1 KRAS
25
Show member pathways
11.57 AIP CTNNB1 FH HRAS KRAS MEN1
26 11.46 AIP HRAS KRAS
27 11.4 CTNNB1 HRAS IGF1 KRAS TP53
28 11.31 IGF1 INS KRAS
29
Show member pathways
11.15 HRAS POMC TRH
30 11.13 CTNNB1 HRAS KRAS
31 11.08 HRAS INS KRAS TP53
32
Show member pathways
11.02 HRAS IGF1 KRAS
33 10.78 CTNNB1 SST
34 10.78 HRAS KRAS
35 10.77 CTNNB1 MEN1

GO Terms for Cell Type Benign Neoplasm

Biological processes related to Cell Type Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 22)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.98 CTNNB1 HRAS MEN1 SST TP53
2 positive regulation of cell migration GO:0030335 9.9 HRAS IGF1 INS PDCD10
3 cellular protein metabolic process GO:0044267 9.89 IGF1 INS MEN1 PRL
4 cell proliferation GO:0008283 9.85 CD34 CTNNB1 HRAS IGF1 PRL TP53
5 negative regulation of gene expression GO:0010629 9.83 CD34 CTNNB1 HRAS IGF1 PDCD10
6 positive regulation of MAPK cascade GO:0043410 9.8 CTNNB1 HRAS IGF1 INS
7 cell-cell signaling GO:0007267 9.8 INS POMC PTH SST TRH
8 positive regulation of epithelial cell proliferation GO:0050679 9.75 HRAS IGF1 PRL
9 positive regulation of MAP kinase activity GO:0043406 9.74 HRAS KRAS PDCD10
10 positive regulation of cell proliferation GO:0008284 9.7 CTNNB1 HRAS IGF1 INS KRAS PDCD10
11 positive regulation of glucose import GO:0046326 9.65 IGF1 INS PTH
12 homeostasis of number of cells within a tissue GO:0048873 9.63 FH KRAS PTH
13 negative regulation of telomerase activity GO:0051974 9.61 MEN1 TP53
14 Ras protein signal transduction GO:0007265 9.56 HRAS IGF1 KRAS TP53
15 endothelial tube morphogenesis GO:0061154 9.55 CCM2 CTNNB1
16 negative regulation of feeding behavior GO:2000252 9.54 INS TRH
17 response to isolation stress GO:0035900 9.52 HRAS KRAS
18 hormone-mediated apoptotic signaling pathway GO:0008628 9.51 PTH SST
19 positive regulation of glycogen biosynthetic process GO:0045725 9.5 IGF1 INS PTH
20 regulation of signaling receptor activity GO:0010469 9.5 IGF1 INS POMC PRL PTH SST
21 positive regulation of gene expression GO:0010628 9.23 CD34 CTNNB1 HRAS IGF1 INS KRAS
22 positive regulation of transcription by RNA polymerase II GO:0045944 10.1 CTNNB1 HRAS IGF1 MEN1 POMC PTH

Molecular functions related to Cell Type Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein N-terminus binding GO:0047485 9.26 MEN1 PDCD10 PTH TP53
2 hormone activity GO:0005179 9.17 IGF1 INS POMC PRL PTH SST

Sources for Cell Type Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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