MCID: CLL012
MIFTS: 34

Cell Type Benign Neoplasm

Categories: Cancer diseases

Aliases & Classifications for Cell Type Benign Neoplasm

MalaCards integrated aliases for Cell Type Benign Neoplasm:

Name: Cell Type Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060084

Summaries for Cell Type Benign Neoplasm

Disease Ontology : 12 A benign neoplasm that is classified by the type of cell or tissue from which it is derived.

MalaCards based summary : Cell Type Benign Neoplasm is related to adenoma and lipomatosis, multiple. An important gene associated with Cell Type Benign Neoplasm is POMC (Proopiomelanocortin), and among its related pathways/superpathways are G-Beta Gamma Signaling and fMLP Pathway. Affiliated tissues include pituitary, thyroid and lung, and related phenotypes are Decreased viability in esophageal squamous lineage and Reduced mammosphere formation

Related Diseases for Cell Type Benign Neoplasm

Diseases related to Cell Type Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 177)
# Related Disease Score Top Affiliating Genes
1 adenoma 30.8 AIP APC CTNNB1 CYP11B2 GNAS IGF1
2 lipomatosis, multiple 11.1
3 gonadoblastoma 11.1
4 ameloblastoma 11.1
5 leiomyoma 11.1
6 chondroma 11.1
7 benign mesothelioma 11.1
8 adenofibroma 11.1
9 angiomyolipoma 11.1
10 ganglioglioma 11.1
11 adenohypophysitis 10.6 POMC PRL
12 schimmelpenning-feuerstein-mims syndrome 10.6 HRAS KRAS
13 paronychia 10.6 HRAS KRAS
14 gallbladder adenoma 10.6 CTNNB1 HRAS
15 pancreatic somatostatinoma 10.6 MEN1 SST
16 aldosterone-producing adenoma 10.6 CYP11B2 KCNJ5
17 bronchus adenoma 10.6 POMC SST
18 attenuated familial adenomatous polyposis 10.6 APC MUTYH
19 bronchial adenomas/carcinoids childhood 10.6 POMC SST
20 respiratory system disease 10.6 HRAS KRAS TP53
21 primary hyperparathyroidism 10.6 MEN1 PRL PTH
22 suppression of tumorigenicity 12 10.6 CTNNB1 HRAS TP53
23 silent pituitary adenoma 10.6 AIP MEN1
24 null pituitary adenoma 10.6 AIP MEN1
25 parathyroid transitional clear cell adenoma 10.6 MEN1 PTH
26 chiasmal syndrome 10.5 POMC PRL SST
27 sigmoid neoplasm 10.5 HRAS KRAS
28 pituitary carcinoma 10.5 POMC PRL SST
29 insulin-like growth factor i 10.5 IGF1 PRL SST
30 prolactin producing pituitary tumor 10.5 PRL SST TP53
31 nelson syndrome 10.5 POMC PRL SST
32 thymic neuroendocrine tumor 10.5 HRAS MEN1
33 tsh producing pituitary tumor 10.5 POMC PRL SST
34 secondary hypertrophic osteoarthropathy 10.5 HRAS KRAS POMC
35 nasal cavity adenocarcinoma 10.5 HRAS KRAS TP53
36 pituitary apoplexy 10.5 AIP POMC PRL
37 acidophil adenoma 10.5 IGF1 POMC SST
38 biliary papillomatosis 10.5 HRAS KRAS TP53
39 chromophobe adenoma 10.5 POMC PRL TP53
40 empty sella syndrome 10.5 IGF1 POMC PRL
41 sheehan syndrome 10.5 IGF1 POMC PRL
42 clear cell adenoma 10.5 CTNNB1 MEN1 PTH
43 scleredema adultorum 10.5 POMC PTH
44 liver angiosarcoma 10.5 HRAS KRAS TP53
45 pituitary-dependent cushing's disease 10.5 POMC PRL SST
46 ampulla of vater cancer 10.5 HRAS KRAS TP53
47 ectopic cushing syndrome 10.5 MEN1 POMC SST
48 ovary adenocarcinoma 10.5 HRAS KRAS TP53
49 bile duct adenocarcinoma 10.5 HRAS KRAS TP53
50 hypothyroidism, congenital, nongoitrous, 4 10.5 IGF1 POMC PRL

Graphical network of the top 20 diseases related to Cell Type Benign Neoplasm:



Diseases related to Cell Type Benign Neoplasm

Symptoms & Phenotypes for Cell Type Benign Neoplasm

GenomeRNAi Phenotypes related to Cell Type Benign Neoplasm according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.65 APC CTNNB1 GNAS HRAS KCNJ5 KRAS
2 Reduced mammosphere formation GR00396-S 9.28 FH GNAS HRAS IGF1 KCNJ5 KRAS

MGI Mouse Phenotypes related to Cell Type Benign Neoplasm:

47 (show all 23)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.5 AIP APC CTNNB1 CYP11B2 FH GNAS
2 cardiovascular system MP:0005385 10.46 AIP APC CTNNB1 CYP11B2 GNAS HRAS
3 endocrine/exocrine gland MP:0005379 10.43 AIP APC CTNNB1 CYP11B2 GNAS HRAS
4 cellular MP:0005384 10.42 AIP APC CTNNB1 FH GNAS IGF1
5 growth/size/body region MP:0005378 10.42 AIP APC CTNNB1 CYP11B2 GNAS HRAS
6 immune system MP:0005387 10.38 APC CTNNB1 CYP11B2 GNAS IGF1 KRAS
7 mortality/aging MP:0010768 10.38 AIP APC CTNNB1 FH GNAS HRAS
8 hematopoietic system MP:0005397 10.3 APC CTNNB1 CYP11B2 GNAS IGF1 KRAS
9 integument MP:0010771 10.26 AIP APC CTNNB1 GNAS HRAS IGF1
10 neoplasm MP:0002006 10.25 AIP APC CTNNB1 GNAS HRAS IGF1
11 nervous system MP:0003631 10.25 APC CTNNB1 CYP11B2 GNAS HRAS IGF1
12 craniofacial MP:0005382 10.2 APC CTNNB1 GNAS HRAS KRAS MEN1
13 digestive/alimentary MP:0005381 10.19 APC CTNNB1 HRAS KRAS MEN1 MLH1
14 liver/biliary system MP:0005370 10.19 AIP APC CTNNB1 CYP11B2 GNAS KRAS
15 muscle MP:0005369 10.06 APC CTNNB1 GNAS IGF1 KRAS MEN1
16 limbs/digits/tail MP:0005371 10.05 APC CTNNB1 GNAS IGF1 KRAS PTH
17 hearing/vestibular/ear MP:0005377 10.04 APC CTNNB1 GNAS IGF1 KRAS TP53
18 normal MP:0002873 9.97 APC CTNNB1 GNAS HRAS IGF1 KRAS
19 no phenotypic analysis MP:0003012 9.91 CTNNB1 GNAS HRAS KRAS POMC SST
20 renal/urinary system MP:0005367 9.9 APC CTNNB1 CYP11B2 FH GNAS HRAS
21 pigmentation MP:0001186 9.65 APC CTNNB1 KRAS POMC TP53
22 reproductive system MP:0005389 9.65 APC CTNNB1 CYP11B2 IGF1 KRAS MEN1
23 skeleton MP:0005390 9.28 APC CTNNB1 GNAS HRAS IGF1 KRAS

Drugs & Therapeutics for Cell Type Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Cell Type Benign Neoplasm

Genetic Tests for Cell Type Benign Neoplasm

Anatomical Context for Cell Type Benign Neoplasm

MalaCards organs/tissues related to Cell Type Benign Neoplasm:

42
Pituitary, Thyroid, Lung, Colon, Breast, Ovary, Pancreas

Publications for Cell Type Benign Neoplasm

Variations for Cell Type Benign Neoplasm

Expression for Cell Type Benign Neoplasm

Search GEO for disease gene expression data for Cell Type Benign Neoplasm.

Pathways for Cell Type Benign Neoplasm

Pathways related to Cell Type Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 42)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.96 CTNNB1 GNAS HRAS KCNJ5 KRAS POMC
2
Show member pathways
12.95 CTNNB1 GNAS HRAS IGF1 KRAS TP53
3
Show member pathways
12.76 APC CTNNB1 GNAS HRAS IGF1 KRAS
4
Show member pathways
12.75 APC CTNNB1 HRAS IGF1 KRAS MLH1
5
Show member pathways
12.67 CTNNB1 GNAS HRAS IGF1 KRAS
6
Show member pathways
12.65 APC CTNNB1 HRAS KRAS TP53
7
Show member pathways
12.64 GNAS HRAS IGF1 KRAS TP53
8
Show member pathways
12.61 APC CTNNB1 HRAS IGF1 KRAS MLH1
9
Show member pathways
12.6 CTNNB1 GNAS HRAS IGF1 KRAS
10
Show member pathways
12.43 APC HRAS IGF1 KRAS TP53
11 12.39 APC CTNNB1 GNAS TP53
12
Show member pathways
12.38 CTNNB1 HRAS KRAS TP53
13
Show member pathways
12.35 APC CTNNB1 HRAS IGF1 KRAS
14 12.26 APC CTNNB1 HRAS KRAS TP53
15 12.2 CTNNB1 HRAS IGF1 KRAS TP53
16
Show member pathways
12.16 CTNNB1 IGF1 POMC REN
17
Show member pathways
12.06 HRAS IGF1 KRAS TP53
18 12 APC CTNNB1 FH GNAS HRAS IGF1
19 11.97 APC CTNNB1 HRAS IGF1 KRAS
20 11.95 APC CTNNB1 HRAS KRAS
21 11.91 CTNNB1 HRAS KRAS TP53
22 11.9 GNAS HRAS KCNJ5 KRAS
23 11.85 APC CTNNB1 GNAS KRAS MLH1 TP53
24 11.83 CTNNB1 GNAS POMC
25 11.83 APC CTNNB1 HRAS KRAS TP53
26 11.79 GNAS HRAS KRAS
27 11.75 POMC PRL TP53
28 11.69 HRAS KRAS TP53
29 11.63 HRAS KRAS TP53
30 11.63 HRAS KRAS TP53
31 11.56 GNAS HRAS IGF1 KRAS
32 11.51 HRAS KRAS MLH1 TP53
33 11.48 APC CTNNB1 HRAS IGF1 KRAS TP53
34 11.45 AIP HRAS KRAS
35 11.39 APC CTNNB1 MEN1
36 11.35 GNAS HRAS IGF1 KRAS
37 11.27 HRAS KRAS TP53
38
Show member pathways
11.1 HRAS IGF1 KRAS
39 11.03 APC CTNNB1 HRAS KRAS
40 10.79 CTNNB1 SST
41 10.79 HRAS KRAS
42 10.79 CTNNB1 MEN1

GO Terms for Cell Type Benign Neoplasm

Cellular components related to Cell Type Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 beta-catenin destruction complex GO:0030877 8.96 APC CTNNB1
2 Wnt signalosome GO:1990909 8.62 APC CTNNB1

Biological processes related to Cell Type Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 17)
# Name GO ID Score Top Affiliating Genes
1 cellular response to DNA damage stimulus GO:0006974 9.96 APC MEN1 MLH1 MUTYH TP53
2 regulation of signaling receptor activity GO:0010469 9.95 IGF1 POMC PRL PTH SST
3 positive regulation of gene expression GO:0010628 9.93 CTNNB1 HRAS IGF1 KRAS TP53
4 cell proliferation GO:0008283 9.76 CTNNB1 HRAS IGF1 TP53
5 positive regulation of osteoblast differentiation GO:0045669 9.67 CTNNB1 GNAS IGF1
6 negative regulation of cell proliferation GO:0008285 9.63 APC CTNNB1 HRAS MEN1 SST TP53
7 skeletal system development GO:0001501 9.62 CTNNB1 GNAS IGF1 PTH
8 negative regulation of telomerase activity GO:0051974 9.57 MEN1 TP53
9 positive regulation of epithelial cell proliferation GO:0050679 9.52 HRAS IGF1
10 response to isolation stress GO:0035900 9.48 HRAS KRAS
11 hair follicle placode formation GO:0060789 9.43 CTNNB1 GNAS
12 homeostasis of number of cells within a tissue GO:0048873 9.43 FH KRAS PTH
13 hormone-mediated apoptotic signaling pathway GO:0008628 9.4 PTH SST
14 response to parathyroid hormone GO:0071107 9.37 GNAS PTH
15 Ras protein signal transduction GO:0007265 9.26 HRAS IGF1 KRAS TP53
16 response to drug GO:0042493 9.02 CTNNB1 GNAS PTH REN SST
17 positive regulation of transcription by RNA polymerase II GO:0045944 10.05 CTNNB1 HRAS IGF1 MEN1 POMC PTH

Molecular functions related to Cell Type Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MutSalpha complex binding GO:0032407 9.16 MLH1 MUTYH
2 insulin-like growth factor receptor binding GO:0005159 9.13 GNAS IGF1 REN
3 hormone activity GO:0005179 9.02 IGF1 POMC PRL PTH SST

Sources for Cell Type Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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