MCID: CLL012
MIFTS: 32

Cell Type Benign Neoplasm

Categories: Cancer diseases, Genetic diseases, Respiratory diseases, Skin diseases, Rare diseases

Aliases & Classifications for Cell Type Benign Neoplasm

MalaCards integrated aliases for Cell Type Benign Neoplasm:

Name: Cell Type Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060084

Summaries for Cell Type Benign Neoplasm

Disease Ontology : 12 A benign neoplasm that is classified by the type of cell or tissue from which it is derived.

MalaCards based summary : Cell Type Benign Neoplasm is related to hemangioma and adenoma. An important gene associated with Cell Type Benign Neoplasm is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Endometrial cancer and PI3K-Akt signaling pathway. Related phenotypes are Reduced mammosphere formation and cardiovascular system

Related Diseases for Cell Type Benign Neoplasm

Diseases in the Small Cell Carcinoma family:

Basal Cell Carcinoma 1 Basal Cell Carcinoma 2
Basal Cell Carcinoma 3 Basal Cell Carcinoma 4
Basal Cell Carcinoma 5 Basal Cell Carcinoma 6
Basal Cell Carcinoma 7 Cell Type Cancer
Cell Type Benign Neoplasm Basal Cell Carcinoma
Large Cell Carcinoma Basal Cell Carcinoma, Multiple

Diseases related to Cell Type Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 180)
# Related Disease Score Top Affiliating Genes
1 hemangioma 32.7 CCM2 CD34 KRAS KRIT1
2 adenoma 31.1 AIP CTNNB1 IGF1 KCNJ5 KRAS MEN1
3 bronchus adenoma 11.3 POMC SST
4 parathyroid transitional clear cell adenoma 11.2 MEN1 PTH
5 silent pituitary adenoma 11.2 AIP MEN1
6 null pituitary adenoma 11.2 AIP MEN1
7 chiasmal syndrome 11.2 POMC PRL SST
8 pituitary carcinoma 11.2 POMC PRL SST
9 thymic neuroendocrine tumor 11.2 HRAS MEN1
10 prolactin producing pituitary tumor 11.2 PRL SST TP53
11 nelson syndrome 11.2 POMC PRL SST
12 sigmoid neoplasm 11.2 HRAS KRAS
13 rare adenocarcinoma of the breast 11.2 KRAS TP53
14 clear cell adenoma 11.1 CTNNB1 MEN1 PTH
15 adult hepatocellular carcinoma 11.1 CTNNB1 TP53
16 scleredema adultorum 11.1 INS POMC PTH
17 ectopic cushing syndrome 11.1 MEN1 POMC SST
18 acidophil adenoma 11.1 IGF1 POMC SST
19 secondary hypertrophic osteoarthropathy 11.1 HRAS KRAS POMC
20 periampullary adenoma 11.1 HRAS KRAS SST
21 empty sella syndrome 11.1 IGF1 POMC PRL
22 nasal cavity adenocarcinoma 11.1 HRAS KRAS TP53
23 pancreatic gastrinoma 11.1 MEN1 SST
24 ectrodactyly, ectodermal dysplasia, and cleft lip/palate syndrome 3 11.1 CTNNB1 KRAS TP53
25 sex differentiation disease 11.1 INS POMC PRL
26 hypothyroidism, congenital, nongoitrous, 4 11.1 IGF1 POMC PRL
27 adrenal gland hyperfunction 11.1 POMC PRL SST
28 biliary papillomatosis 11.1 HRAS KRAS TP53
29 ampulla of vater neoplasm 11.1 HRAS KRAS SST
30 hyperplastic polyposis syndrome 11.1 KRAS MUTYH TP53
31 granulosa cell tumor of the ovary 11.1 INS PRL TP53
32 mixed cell type cancer 11.1 HRAS KRAS TP53
33 pineal region choriocarcinoma 11.1 CD34 IGF1
34 mutyh-associated polyposis 11.1 KRAS MUTYH TP53
35 cellular neurofibroma 11.1 CD34 TP53
36 ovary adenocarcinoma 11.1 HRAS KRAS TP53
37 tsh producing pituitary tumor 11.1 PRL SST
38 glomangiosarcoma 11.1 REN TP53
39 multiple endocrine neoplasia, type iv 11.1 AIP MEN1 PRL
40 biliary tract neoplasm 11.1 HRAS KRAS TP53
41 type 1 diabetes mellitus 15 11.1 HRAS INS
42 gastrinoma 11.1 INS MEN1 SST
43 human venous malformation 11.1 CCM2 KRIT1 PDCD10
44 islet cell tumor 11.1 INS MEN1 SST
45 bile duct adenocarcinoma 11.1 HRAS KRAS TP53
46 prostate adenoid cystic carcinoma 11.1 HRAS POMC
47 tibial adamantinoma 11.1 CD34 PTH
48 growth hormone secreting pituitary adenoma 11.1 AIP PRL SST
49 carcinoid syndrome 11.1 IGF1 MEN1 SST
50 skin squamous cell carcinoma 11.1 HRAS KRAS TP53

Graphical network of the top 20 diseases related to Cell Type Benign Neoplasm:



Diseases related to Cell Type Benign Neoplasm

Symptoms & Phenotypes for Cell Type Benign Neoplasm

GenomeRNAi Phenotypes related to Cell Type Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.28 CD34 FH HRAS IGF1 KCNJ5 KRAS

MGI Mouse Phenotypes related to Cell Type Benign Neoplasm:

46 (show all 19)
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 10.45 AIP CTNNB1 CCM2 HRAS IGF1 KCNJ5
2 homeostasis/metabolism MP:0005376 10.42 AIP CTNNB1 CCM2 FH CD34 HRAS
3 cellular MP:0005384 10.41 CD34 AIP CTNNB1 CCM2 FH INS
4 growth/size/body region MP:0005378 10.4 AIP CTNNB1 CCM2 INS HRAS IGF1
5 mortality/aging MP:0010768 10.33 AIP CTNNB1 CCM2 FH HRAS IGF1
6 behavior/neurological MP:0005386 10.32 TP53 CTNNB1 CCM2 HRAS INS KRAS
7 immune system MP:0005387 10.32 CTNNB1 CCM2 CD34 INS IGF1 KRAS
8 endocrine/exocrine gland MP:0005379 10.28 AIP CTNNB1 HRAS INS IGF1 KRAS
9 integument MP:0010771 10.27 AIP CTNNB1 CCM2 CD34 HRAS IGF1
10 hematopoietic system MP:0005397 10.25 TP53 CD34 CTNNB1 CCM2 INS IGF1
11 embryo MP:0005380 10.2 AIP CTNNB1 CCM2 INS KRAS KRIT1
12 craniofacial MP:0005382 10.16 CTNNB1 CCM2 HRAS KRAS KRIT1 MEN1
13 neoplasm MP:0002006 10.13 AIP CTNNB1 CD34 HRAS IGF1 KRAS
14 nervous system MP:0003631 10.13 CTNNB1 CCM2 HRAS IGF1 KRAS INS
15 muscle MP:0005369 10.07 CTNNB1 CCM2 INS IGF1 KRAS KRIT1
16 liver/biliary system MP:0005370 10.03 AIP CTNNB1 INS MEN1 KRAS PRL
17 no phenotypic analysis MP:0003012 9.7 TP53 CTNNB1 HRAS INS KRAS POMC
18 normal MP:0002873 9.65 CTNNB1 CCM2 HRAS INS IGF1 KRAS
19 renal/urinary system MP:0005367 9.28 CTNNB1 FH HRAS INS IGF1 KRAS

Drugs & Therapeutics for Cell Type Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Cell Type Benign Neoplasm

Genetic Tests for Cell Type Benign Neoplasm

Anatomical Context for Cell Type Benign Neoplasm

Publications for Cell Type Benign Neoplasm

Variations for Cell Type Benign Neoplasm

Expression for Cell Type Benign Neoplasm

Search GEO for disease gene expression data for Cell Type Benign Neoplasm.

Pathways for Cell Type Benign Neoplasm

Pathways related to Cell Type Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 33)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.78 CTNNB1 HRAS IGF1 INS KRAS TP53
2
Show member pathways
12.74 CTNNB1 HRAS IGF1 INS KRAS PRL
3 12.73 CTNNB1 FH HRAS IGF1 KRAS TP53
4 12.69 HRAS IGF1 INS KRAS TP53
5
Show member pathways
12.68 CTNNB1 HRAS IGF1 KRAS TP53
6
Show member pathways
12.52 CTNNB1 HRAS IGF1 INS KRAS KRIT1
7
Show member pathways
12.41 HRAS IGF1 INS KRAS TP53
8
Show member pathways
12.38 CTNNB1 HRAS KRAS TP53
9
Show member pathways
12.36 HRAS IGF1 INS TP53
10 12.35 CTNNB1 HRAS KRAS TP53
11
Show member pathways
12.14 AIP CTNNB1 FH HRAS INS KCNJ5
12 12.03 CTNNB1 HRAS IGF1 KRAS
13
Show member pathways
12.02 HRAS IGF1 INS KRAS
14 12.02 CTNNB1 HRAS IGF1 KRAS TP53
15
Show member pathways
11.91 CTNNB1 IGF1 INS POMC REN
16 11.89 CTNNB1 HRAS KRAS TP53
17 11.87 CTNNB1 HRAS KRAS TP53
18 11.8 HRAS IGF1 INS TP53
19
Show member pathways
11.73 HRAS IGF1 INS KRAS TP53
20 11.72 POMC PRL TP53
21 11.67 HRAS KRAS TP53
22 11.6 HRAS KRAS TP53
23 11.59 HRAS KRAS TP53
24 11.55 HRAS IGF1 KRAS
25 11.45 AIP HRAS KRAS
26 11.4 CTNNB1 HRAS IGF1 KRAS TP53
27 11.31 IGF1 INS KRAS
28 11.15 CTNNB1 HRAS KRAS
29 11.15 HRAS INS KRAS TP53
30
Show member pathways
11.05 HRAS IGF1 KRAS
31 10.77 CTNNB1 SST
32 10.76 HRAS KRAS
33 10.76 CTNNB1 MEN1

GO Terms for Cell Type Benign Neoplasm

Cellular components related to Cell Type Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.56 IGF1 INS KRIT1 POMC PRL PTH
2 cytoplasm GO:0005737 9.5 AIP CCM2 CD34 CTNNB1 FH HRAS

Biological processes related to Cell Type Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.97 CTNNB1 HRAS MEN1 SST TP53
2 regulation of gene expression GO:0010468 9.91 CTNNB1 IGF1 INS PTH
3 negative regulation of gene expression GO:0010629 9.9 CD34 CTNNB1 HRAS PDCD10
4 cellular protein metabolic process GO:0044267 9.89 IGF1 INS MEN1 PRL
5 positive regulation of cell migration GO:0030335 9.88 HRAS IGF1 INS PDCD10
6 regulation of signaling receptor activity GO:0010469 9.88 IGF1 INS POMC PRL PTH SST
7 cell proliferation GO:0008283 9.85 CD34 CTNNB1 HRAS IGF1 PRL TP53
8 positive regulation of MAPK cascade GO:0043410 9.8 CTNNB1 HRAS IGF1 INS
9 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.79 IGF1 INS TP53
10 regulation of blood pressure GO:0008217 9.76 CD34 POMC REN
11 positive regulation of MAP kinase activity GO:0043406 9.73 HRAS KRAS PDCD10
12 positive regulation of DNA replication GO:0045740 9.65 HRAS IGF1 INS
13 positive regulation of glucose import GO:0046326 9.63 IGF1 INS PTH
14 Ras protein signal transduction GO:0007265 9.62 HRAS IGF1 KRAS TP53
15 negative regulation of telomerase activity GO:0051974 9.61 MEN1 TP53
16 homeostasis of number of cells within a tissue GO:0048873 9.61 FH KRAS PTH
17 response to isolation stress GO:0035900 9.55 HRAS KRAS
18 endothelial tube morphogenesis GO:0061154 9.54 CCM2 CTNNB1
19 hormone-mediated apoptotic signaling pathway GO:0008628 9.51 PTH SST
20 positive regulation of cell proliferation GO:0008284 9.5 CTNNB1 HRAS IGF1 INS KRAS PDCD10
21 response to nutrient levels GO:0031667 9.46 IGF1 INS PRL PTH
22 positive regulation of glycogen biosynthetic process GO:0045725 9.43 IGF1 INS PTH
23 positive regulation of gene expression GO:0010628 9.23 CD34 CTNNB1 HRAS IGF1 INS KRAS
24 positive regulation of transcription by RNA polymerase II GO:0045944 10.07 CTNNB1 HRAS IGF1 MEN1 POMC PTH

Molecular functions related to Cell Type Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein N-terminus binding GO:0047485 9.46 MEN1 PDCD10 PTH TP53
2 receptor activator activity GO:0030546 9.26 IGF1 INS
3 insulin-like growth factor receptor binding GO:0005159 9.13 IGF1 INS REN
4 hormone activity GO:0005179 9.1 IGF1 INS POMC PRL PTH SST

Sources for Cell Type Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....