MCID: CLL013
MIFTS: 35

Cell Type Cancer

Categories: Cancer diseases, Genetic diseases, Respiratory diseases, Skin diseases, Rare diseases

Aliases & Classifications for Cell Type Cancer

MalaCards integrated aliases for Cell Type Cancer:

Name: Cell Type Cancer 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0050687

Summaries for Cell Type Cancer

Disease Ontology : 12 A cancer that is classified by the type of cell from which it is derived.

MalaCards based summary : Cell Type Cancer is related to mixed cell type cancer and mesothelioma, malignant. An important gene associated with Cell Type Cancer is TP53 (Tumor Protein P53), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. Related phenotypes are Decreased viability and Decreased viability

Related Diseases for Cell Type Cancer

Diseases in the Small Cell Carcinoma family:

Basal Cell Carcinoma 1 Basal Cell Carcinoma 2
Basal Cell Carcinoma 3 Basal Cell Carcinoma 4
Basal Cell Carcinoma 5 Basal Cell Carcinoma 6
Basal Cell Carcinoma 7 Cell Type Cancer
Cell Type Benign Neoplasm Basal Cell Carcinoma
Large Cell Carcinoma Basal Cell Carcinoma, Multiple

Diseases related to Cell Type Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 268)
# Related Disease Score Top Affiliating Genes
1 mixed cell type cancer 34.9 ENO2 ERBB2 HRAS KRAS KRT7 TP53
2 mesothelioma, malignant 32.6 CDH1 CDKN2A KRT7
3 spitz nevus 11.4 CDKN2A HRAS TP53
4 paronychia 11.4 EGFR HRAS KRAS
5 rare adenocarcinoma of the breast 11.4 AKT1 KRAS TP53
6 bladder carcinoma in situ 11.4 CDKN2A KRT7 TP53
7 sigmoid neoplasm 11.4 CEACAM5 HRAS KRAS
8 breast squamous cell carcinoma 11.4 EGFR ERBB2 TP53
9 oncocytic breast carcinoma 11.4 EGFR ERBB2 KRT7
10 scrotal carcinoma 11.4 CDKN2A SMUG1 TP53
11 bronchiolo-alveolar adenocarcinoma 11.4 EGFR KRAS KRT7
12 oral leukoplakia 11.4 CDKN2A ERBB2 TP53
13 glycogen-rich clear cell breast carcinoma 11.4 CDKN2A KRT7 TP53
14 secondary hypertrophic osteoarthropathy 11.4 HRAS KRAS SMUG1
15 microglandular adenosis 11.4 EGFR ERBB2 TP53
16 apocrine adenoma 11.4 CEACAM5 HRAS KRAS
17 mature teratoma 11.4 KRAS SMUG1 TP53
18 pleomorphic adenoma carcinoma 11.4 ENO2 ERBB2 TP53
19 pulmonary blastoma 11.4 EGFR KRAS TP53
20 anal canal adenocarcinoma 11.4 HRAS KRAS KRT7
21 intracystic papillary adenoma 11.4 CEACAM5 EGFR ERBB2
22 anal squamous cell carcinoma 11.4 AKT1 CDKN2A TP53
23 pleomorphic carcinoma 11.4 EGFR KRT7 TP53
24 lung adenoid cystic carcinoma 11.4 EGFR HRAS KRAS
25 oropharynx cancer 11.4 CDKN2A EGFR SMUG1 TP53
26 penile cancer 11.4 CDKN2A EGFR HRAS TP53
27 glioma susceptibility 1 11.4 ERBB2 IDH1 TP53
28 intracranial chondrosarcoma 11.4 CEACAM5 IDH1 TP53
29 ampulla of vater neoplasm 11.4 HRAS KRAS KRT7
30 acneiform dermatitis 11.4 EGFR ERBB2 HRAS KRAS
31 splenic tuberculosis 11.4 CEACAM5 IL2 SMUG1
32 skin squamous cell carcinoma 11.4 CDKN2A HRAS KRAS TP53
33 aggressive digital papillary adenocarcinoma 11.4 CEACAM5 HRAS KRAS
34 vulva cancer 11.4 CDKN2A EGFR KRT7 TP53
35 breast intraductal proliferative lesion 11.4 EGFR ERBB2
36 endocervical adenocarcinoma 11.4 CDKN2A KRT7 TP53
37 hidradenocarcinoma 11.4 EGFR ERBB2 KRT7 TP53
38 meningeal melanomatosis 11.4 CDKN2A ENO2 HRAS TP53
39 epithelial-myoepithelial carcinoma 11.4 HRAS KRT7 TP53
40 barrett's adenocarcinoma 11.3 CDKN2A ERBB2 KRAS TP53
41 adenoid basal cell carcinoma 11.3 CDKN2A CEACAM5 KRT7
42 atypical follicular adenoma 11.3 CEACAM5 ENO2 TP53
43 adenosquamous carcinoma 11.3 EGFR KRAS KRT7 TP53
44 liver angiosarcoma 11.3 ENO2 HRAS KRAS TP53
45 necrotizing sialometaplasia 11.3 CDKN2A KRT7 TP53
46 gliomatosis cerebri 11.3 EGFR IDH1 TP53
47 mucinous adenocarcinoma 11.3 CDKN2A EGFR KRAS KRT7
48 eccrine adenocarcinoma 11.3 CEACAM5 KRT7 SMUG1
49 cecum adenocarcinoma 11.3 HRAS KRAS KRT7 SMUG1
50 ovary serous adenocarcinoma 11.3 CEACAM5 HRAS KRAS

Graphical network of the top 20 diseases related to Cell Type Cancer:



Diseases related to Cell Type Cancer

Symptoms & Phenotypes for Cell Type Cancer

GenomeRNAi Phenotypes related to Cell Type Cancer according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.77 EGFR HRAS KRAS
2 Decreased viability GR00106-A-0 9.77 KRAS
3 Decreased viability GR00221-A-1 9.77 AKT1 CDH1 CDKN2A EGFR HRAS KRAS
4 Decreased viability GR00221-A-2 9.77 AKT1 HRAS KRAS
5 Decreased viability GR00221-A-3 9.77 AKT1 CDKN2A HRAS
6 Decreased viability GR00221-A-4 9.77 AKT1 CDKN2A EGFR
7 Decreased viability GR00301-A 9.77 CDH1 KRAS
8 Decreased viability GR00381-A-1 9.77 KRAS
9 Decreased viability GR00402-S-2 9.77 CDH1 CDKN2A EGFR HRAS KRAS AKT1

MGI Mouse Phenotypes related to Cell Type Cancer:

46 (show all 20)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.43 VEGFA TP53 TUBB3 CDH1 AKT1 CDKN2A
2 homeostasis/metabolism MP:0005376 10.43 TP53 VEGFA AKT1 CDKN2A AREG CDH1
3 growth/size/body region MP:0005378 10.36 VEGFA TP53 CDH1 AKT1 CDKN2A AREG
4 cardiovascular system MP:0005385 10.33 VEGFA TP53 CDH1 AKT1 CDKN2A AREG
5 mortality/aging MP:0010768 10.33 VEGFA TP53 TUBB3 CDH1 AKT1 CDKN2A
6 digestive/alimentary MP:0005381 10.31 TP53 VEGFA CDKN2A AREG CDH1 EGFR
7 endocrine/exocrine gland MP:0005379 10.3 VEGFA TP53 CDH1 AKT1 CDKN2A AREG
8 hematopoietic system MP:0005397 10.28 VEGFA TP53 AKT1 CDKN2A AREG EGFR
9 integument MP:0010771 10.27 TP53 VEGFA AKT1 CDKN2A AREG CDH1
10 immune system MP:0005387 10.25 VEGFA TP53 TLR9 CDH1 AKT1 CDKN2A
11 neoplasm MP:0002006 10.17 VEGFA TP53 CDKN2A CDH1 EGFR AKT1
12 craniofacial MP:0005382 10.12 VEGFA TP53 ERBB2 EGFR HRAS ENO2
13 no phenotypic analysis MP:0003012 10.1 TP53 VEGFA CDH1 CDKN2A EGFR HRAS
14 liver/biliary system MP:0005370 10.02 VEGFA TP53 AKT1 CDKN2A EGFR KRAS
15 reproductive system MP:0005389 9.96 VEGFA TP53 CDH1 AKT1 CDKN2A AREG
16 respiratory system MP:0005388 9.93 TP53 TUBB3 VEGFA AKT1 CDKN2A HRAS
17 renal/urinary system MP:0005367 9.87 VEGFA TP53 TLR9 EGFR HRAS KRAS
18 pigmentation MP:0001186 9.85 TP53 CDKN2A EGFR MLANA PMEL KRAS
19 skeleton MP:0005390 9.61 VEGFA TP53 AKT1 CDKN2A ERBB2 EGFR
20 vision/eye MP:0005391 9.23 VEGFA TP53 AREG CDKN2A EGFR KRAS

Drugs & Therapeutics for Cell Type Cancer

Search Clinical Trials , NIH Clinical Center for Cell Type Cancer

Genetic Tests for Cell Type Cancer

Anatomical Context for Cell Type Cancer

Publications for Cell Type Cancer

Variations for Cell Type Cancer

Expression for Cell Type Cancer

Search GEO for disease gene expression data for Cell Type Cancer.

Pathways for Cell Type Cancer

Pathways related to Cell Type Cancer according to GeneCards Suite gene sharing:

(show top 50) (show all 103)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.94 AKT1 AREG CDH1 CDKN2A EGFR ERBB2
2
Show member pathways
13.81 AKT1 AREG CDKN2A EGFR ERBB2 HRAS
3
Show member pathways
13.6 AKT1 AREG EGFR ERBB2 HRAS IL2
4
Show member pathways
13.58 AKT1 EGFR ERBB2 HRAS IL2 KRAS
5
Show member pathways
13.5 AKT1 AREG EGFR ERBB2 HRAS IL2
6
Show member pathways
13.45 AKT1 EGFR ERBB2 HRAS IL2 KRAS
7
Show member pathways
13.4 AKT1 AREG EGFR ERBB2 HRAS IL2
8
Show member pathways
13.39 AKT1 CEACAM5 HRAS IL2 KRAS TP53
9
Show member pathways
13.38 AKT1 AREG CDH1 EGFR ERBB2 HRAS
10
Show member pathways
13.35 AKT1 AREG CDH1 EGFR ERBB2 HRAS
11
Show member pathways
13.16 AKT1 AREG EGFR HRAS IL2 KRAS
12
Show member pathways
13.13 AKT1 AREG EGFR HRAS IL2 KRAS
13
Show member pathways
13.13 AKT1 CDKN2A EGFR HRAS KRAS TUBB3
14
Show member pathways
13.09 AKT1 CDH1 HRAS KRAS TP53 VEGFA
15
Show member pathways
13.03 AKT1 AREG EGFR ERBB2 HRAS IL2
16
Show member pathways
13 AKT1 EGFR ERBB2 HRAS KRAS VEGFA
17
Show member pathways
12.99 AKT1 EGFR ERBB2 HRAS KRAS VEGFA
18
Show member pathways
12.89 AKT1 AREG EGFR ERBB2 HRAS KRAS
19
Show member pathways
12.88 AKT1 CDKN2A HRAS KRAS TP53
20 12.85 AKT1 AREG EGFR ERBB2 HRAS KRAS
21
Show member pathways
12.84 AKT1 CDH1 CDKN2A EGFR ERBB2 HRAS
22
Show member pathways
12.83 AKT1 CDH1 EGFR HRAS KRAS VEGFA
23
Show member pathways
12.83 AKT1 EGFR ERBB2 HRAS KRAS TP53
24
Show member pathways
12.82 AKT1 CDH1 ERBB2 HRAS KRAS TP53
25
Show member pathways
12.78 AKT1 AREG EGFR IL2 TLR9
26
Show member pathways
12.75 AKT1 EGFR HRAS KRAS TP53
27
Show member pathways
12.74 AKT1 EGFR HRAS KRAS VEGFA
28
Show member pathways
12.73 AKT1 CDH1 CDKN2A EGFR ERBB2 HRAS
29
Show member pathways
12.7 AKT1 AREG CDH1 CDKN2A EGFR ERBB2
30
Show member pathways
12.68 AKT1 EGFR ERBB2 HRAS IL2 KRAS
31
Show member pathways
12.67 AKT1 HRAS KRAS TP53 VEGFA
32 12.61 CDKN2A EGFR ERBB2 HRAS KRAS TP53
33
Show member pathways
12.59 AKT1 EGFR ERBB2 HRAS KRAS TP53
34 12.58 AKT1 CDH1 CDKN2A EGFR ERBB2 HRAS
35
Show member pathways
12.56 AKT1 AREG CDH1 EGFR ERBB2 HRAS
36
Show member pathways
12.53 AKT1 EGFR HRAS KRAS TLR9 VEGFA
37 12.52 AKT1 CDKN2A HRAS IL2 KRAS TP53
38
Show member pathways
12.52 AKT1 EGFR ERBB2 HRAS IL2 KRAS
39
Show member pathways
12.47 AKT1 EGFR HRAS KRAS
40
Show member pathways
12.47 AKT1 HRAS KRAS VEGFA
41
Show member pathways
12.42 AKT1 EGFR ERBB2 HRAS KRAS
42
Show member pathways
12.39 AKT1 EGFR ERBB2 HRAS
43 12.37 CDKN2A HRAS KRAS TP53
44
Show member pathways
12.37 AKT1 AREG EGFR ERBB2 HRAS KRAS
45 12.34 AKT1 EGFR ERBB2 HRAS KRAS TP53
46
Show member pathways
12.33 AKT1 AREG EGFR HRAS KRAS VEGFA
47
Show member pathways
12.32 AKT1 HRAS IL2 KRAS TLR9
48
Show member pathways
12.32 AKT1 HRAS KRAS TP53 VEGFA
49 12.3 AKT1 EGFR ERBB2 HRAS KRAS
50 12.28 AKT1 CDKN2A HRAS KRAS TP53

GO Terms for Cell Type Cancer

Cellular components related to Cell Type Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.5 AKT1 AREG CDH1 CDKN2A EGFR ENO2
2 basolateral plasma membrane GO:0016323 9.26 CEACAM5 EGFR ERBB2 TLR9

Biological processes related to Cell Type Cancer according to GeneCards Suite gene sharing:

(show all 24)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.98 AKT1 CEACAM5 EGFR ERBB2 IL2 TP53
2 cytokine-mediated signaling pathway GO:0019221 9.95 AKT1 IL2 KRAS TP53 VEGFA
3 cell proliferation GO:0008283 9.95 AKT1 AREG EGFR ERBB2 HRAS TP53
4 MAPK cascade GO:0000165 9.92 EGFR ERBB2 HRAS IL2 KRAS
5 positive regulation of cell proliferation GO:0008284 9.91 AKT1 AREG EGFR HRAS IL2 KRAS
6 positive regulation of MAPK cascade GO:0043410 9.88 EGFR ERBB2 HRAS TLR9
7 positive regulation of cell growth GO:0030307 9.8 AKT1 EGFR ERBB2 IL2
8 positive regulation of peptidyl-serine phosphorylation GO:0033138 9.79 AKT1 EGFR VEGFA
9 positive regulation of inflammatory response GO:0050729 9.79 EGFR IL2 TLR9
10 cellular response to growth factor stimulus GO:0071363 9.77 AKT1 EGFR ERBB2
11 Ras protein signal transduction GO:0007265 9.76 CDKN2A HRAS KRAS TP53
12 cellular response to epidermal growth factor stimulus GO:0071364 9.74 AKT1 EGFR ERBB2
13 positive regulation of DNA replication GO:0045740 9.73 AREG EGFR HRAS
14 positive regulation of epithelial cell proliferation GO:0050679 9.71 EGFR ERBB2 HRAS VEGFA
15 positive regulation of MAP kinase activity GO:0043406 9.65 EGFR ERBB2 HRAS KRAS VEGFA
16 ERBB2 signaling pathway GO:0038128 9.62 EGFR ERBB2 HRAS KRAS
17 response to isolation stress GO:0035900 9.61 HRAS KRAS
18 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle GO:0031659 9.6 AKT1 EGFR
19 negative regulation of immature T cell proliferation in thymus GO:0033088 9.58 CDKN2A ERBB2
20 positive regulation of gene expression GO:0010628 9.56 AKT1 CDKN2A ERBB2 HRAS KRAS TLR9
21 epidermal growth factor receptor signaling pathway GO:0007173 9.55 AKT1 AREG EGFR HRAS KRAS
22 response to UV-A GO:0070141 9.54 AKT1 EGFR
23 positive regulation of protein phosphorylation GO:0001934 9.17 AKT1 EGFR ERBB2 HRAS IL2 KRAS
24 positive regulation of transcription by RNA polymerase II GO:0045944 10.11 AKT1 CDKN2A EGFR HRAS IL2 TLR9

Molecular functions related to Cell Type Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.91 AKT1 AREG CDH1 CDKN2A EGFR ENO2
2 protein homodimerization activity GO:0042803 9.88 AKT1 CDH1 CEACAM5 IDH1 TLR9 VEGFA
3 nucleotide binding GO:0000166 9.65 AKT1 EGFR ERBB2 HRAS KRAS
4 protein phosphatase binding GO:0019903 9.5 EGFR ERBB2 TP53
5 obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity GO:0004716 9.37 EGFR ERBB2
6 identical protein binding GO:0042802 9.28 AKT1 CDH1 CEACAM5 EGFR ERBB2 IDH1
7 nitric-oxide synthase regulator activity GO:0030235 9.16 AKT1 EGFR

Sources for Cell Type Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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