MCID: CLL007
MIFTS: 33

Cellular Congenital Mesoblastic Nephroma

Categories: Cancer diseases, Nephrological diseases

Aliases & Classifications for Cellular Congenital Mesoblastic Nephroma

MalaCards integrated aliases for Cellular Congenital Mesoblastic Nephroma:

Name: Cellular Congenital Mesoblastic Nephroma 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:8082
NCIt 51 C39815
UMLS 74 C1516474

Summaries for Cellular Congenital Mesoblastic Nephroma

MalaCards based summary : Cellular Congenital Mesoblastic Nephroma is related to congenital mesoblastic nephroma and congenital fibrosarcoma. An important gene associated with Cellular Congenital Mesoblastic Nephroma is NTRK3 (Neurotrophic Receptor Tyrosine Kinase 3), and among its related pathways/superpathways are ERK Signaling and GPCR Pathway. Affiliated tissues include kidney, and related phenotypes are behavior/neurological and cellular

Related Diseases for Cellular Congenital Mesoblastic Nephroma

Graphical network of the top 20 diseases related to Cellular Congenital Mesoblastic Nephroma:



Diseases related to Cellular Congenital Mesoblastic Nephroma

Symptoms & Phenotypes for Cellular Congenital Mesoblastic Nephroma

MGI Mouse Phenotypes related to Cellular Congenital Mesoblastic Nephroma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.03 BDNF NRAS NTRK1 NTRK2 NTRK3 SRC
2 cellular MP:0005384 10.01 BDNF ETV6 GAB2 NRAS NTRK2 SRC
3 growth/size/body region MP:0005378 9.97 BDNF ETV6 NRAS NTRK1 NTRK2 NTRK3
4 endocrine/exocrine gland MP:0005379 9.91 BDNF ETV6 NRAS NTRK2 SRC STAT5A
5 mortality/aging MP:0010768 9.85 BDNF ETV6 GAB2 NRAS NTRK1 NTRK2
6 integument MP:0010771 9.8 BDNF ETV6 NRAS NTRK1 SRC STAT5A
7 normal MP:0002873 9.56 BDNF ETV6 NRAS NTRK1 NTRK2 NTRK3
8 vision/eye MP:0005391 9.1 BDNF NRAS NTRK1 NTRK2 NTRK3 SRC

Drugs & Therapeutics for Cellular Congenital Mesoblastic Nephroma

Search Clinical Trials , NIH Clinical Center for Cellular Congenital Mesoblastic Nephroma

Genetic Tests for Cellular Congenital Mesoblastic Nephroma

Anatomical Context for Cellular Congenital Mesoblastic Nephroma

MalaCards organs/tissues related to Cellular Congenital Mesoblastic Nephroma:

42
Kidney

Publications for Cellular Congenital Mesoblastic Nephroma

Articles related to Cellular Congenital Mesoblastic Nephroma:

(show all 11)
# Title Authors Year
1
Cellular Congenital Mesoblastic Nephroma in a Newborn. ( 28770142 )
2017
2
Cellular congenital mesoblastic nephroma: case report. ( 21541470 )
2011
3
Cellular congenital mesoblastic nephroma with contralateral medullary nephrocalcinosis. ( 15121709 )
2004
4
Complete response of recurrent cellular congenital mesoblastic nephroma to chemotherapy. ( 12218597 )
2002
5
Mixed epithelial and stromal tumor of the kidney lacks the genetic alterations of cellular congenital mesoblastic nephroma. ( 11381370 )
2001
6
Detection of the ETV6-NTRK3 chimeric RNA of infantile fibrosarcoma/cellular congenital mesoblastic nephroma in paraffin-embedded tissue: application to challenging pediatric renal stromal tumors. ( 10658907 )
2000
7
Ultrastructure of cellular congenital mesoblastic nephroma. ( 8883325 )
1996
8
Preoperative chemotherapy of cellular congenital mesoblastic nephroma in a 5-month-old infant. ( 1281666 )
1992
9
Cellular congenital mesoblastic nephroma: what are the options. ( 2545932 )
1989
10
Two chromosomally different cell populations in a partly cellular congenital mesoblastic nephroma. ( 3030229 )
1987
11
Cellular congenital mesoblastic nephroma in a newborn. ( 6097889 )
1984

Variations for Cellular Congenital Mesoblastic Nephroma

Expression for Cellular Congenital Mesoblastic Nephroma

Search GEO for disease gene expression data for Cellular Congenital Mesoblastic Nephroma.

Pathways for Cellular Congenital Mesoblastic Nephroma

Pathways related to Cellular Congenital Mesoblastic Nephroma according to GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.74 BDNF GAB2 NRAS NTRK1 NTRK2 NTRK3
2
Show member pathways
13.64 BDNF NRAS NTRK1 NTRK2 NTRK3 SRC
3
Show member pathways
13.6 BDNF NRAS NTRK1 NTRK2 NTRK3 SRC
4
Show member pathways
13.47 BDNF NRAS NTRK1 NTRK2 NTRK3 SRC
5
Show member pathways
13.42 BDNF NRAS NTRK1 NTRK2 NTRK3 SRC
6
Show member pathways
13.27 BDNF NRAS NTRK1 NTRK2 NTRK3 SRC
7
Show member pathways
13.24 BDNF NRAS NTRK1 NTRK2 NTRK3 SRC
8
Show member pathways
13.22 BDNF NRAS NTRK1 NTRK2 NTRK3 SRC
9
Show member pathways
13.12 BDNF GAB2 NRAS NTRK1 NTRK2 NTRK3
10
Show member pathways
12.99 BDNF NRAS NTRK1 NTRK2 NTRK3 SRC
11
Show member pathways
12.97 BDNF GAB2 NRAS NTRK1 NTRK2 NTRK3
12
Show member pathways
12.82 NRAS NTRK1 NTRK2 NTRK3 SRC
13
Show member pathways
12.81 NRAS SRC STAT5A STAT5B
14
Show member pathways
12.78 GAB2 NRAS NTRK1 SRC STAT5A STAT5B
15 12.77 NRAS NTRK1 STAT5A STAT5B
16
Show member pathways
12.71 BDNF NRAS NTRK2 SRC STAT5A STAT5B
17 12.7 BDNF NRAS NTRK1 NTRK2
18
Show member pathways
12.64 BDNF GAB2 NRAS NTRK1 NTRK2 SRC
19
Show member pathways
12.63 NRAS SRC STAT5A STAT5B
20
Show member pathways
12.63 NRAS NTRK1 SRC STAT5A STAT5B
21
Show member pathways
12.59 BDNF NTRK1 NTRK2 NTRK3 SRC
22
Show member pathways
12.56 NRAS SRC STAT5A STAT5B
23
Show member pathways
12.55 NRAS SRC STAT5A STAT5B
24 12.55 GAB2 NTRK1 NTRK2 NTRK3
25
Show member pathways
12.42 GAB2 NRAS SRC STAT5A STAT5B
26
Show member pathways
12.41 GAB2 NRAS SRC STAT5A
27
Show member pathways
12.41 NRAS NTRK1 NTRK2 NTRK3
28
Show member pathways
12.37 NRAS SRC STAT5A STAT5B
29
Show member pathways
12.33 BDNF GAB2 NRAS NTRK1 NTRK2 NTRK3
30
Show member pathways
12.31 GAB2 NRAS STAT5A STAT5B
31 12.27 NRAS SRC STAT5A STAT5B
32
Show member pathways
12.23 BDNF NTRK1 NTRK2 NTRK3
33 12.19 ETV6 NTRK1 SSX2
34 12.16 GAB2 SRC STAT5A STAT5B
35
Show member pathways
12.15 GAB2 SRC STAT5A STAT5B
36
Show member pathways
12.13 GAB2 NRAS STAT5A STAT5B
37
Show member pathways
12.12 BDNF GAB2 NRAS NTRK2 SRC
38
Show member pathways
12.1 BDNF NRAS NTRK1 NTRK2 NTRK3 SRC
39 12.08 GAB2 NTRK1 NTRK2 SRC
40 12.06 GAB2 NRAS NTRK1 NTRK2 NTRK3
41
Show member pathways
12.03 GAB2 STAT5A STAT5B
42
Show member pathways
12.03 GAB2 NRAS NTRK1 NTRK2 NTRK3 SRC
43 11.96 BDNF NTRK1 NTRK2 NTRK3
44
Show member pathways
11.93 GAB2 STAT5A STAT5B
45
Show member pathways
11.93 NRAS STAT5A STAT5B
46 11.89 NRAS STAT5A STAT5B
47
Show member pathways
11.87 SRC STAT5A STAT5B
48 11.84 NRAS SRC STAT5A STAT5B
49
Show member pathways
11.81 GAB2 NRAS STAT5A STAT5B
50 11.75 SRC STAT5A STAT5B

GO Terms for Cellular Congenital Mesoblastic Nephroma

Cellular components related to Cellular Congenital Mesoblastic Nephroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 receptor complex GO:0043235 9.13 NTRK1 NTRK2 NTRK3
2 axon GO:0030424 8.92 BDNF NTRK1 NTRK2 NTRK3

Biological processes related to Cellular Congenital Mesoblastic Nephroma according to GeneCards Suite gene sharing:

(show all 40)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of cell proliferation GO:0008284 9.98 GAB2 NTRK2 NTRK3 STAT5B
2 nervous system development GO:0007399 9.95 BDNF NTRK1 NTRK2 NTRK3
3 positive regulation of protein phosphorylation GO:0001934 9.83 NTRK1 NTRK2 NTRK3
4 protein autophosphorylation GO:0046777 9.82 NTRK1 NTRK2 SRC
5 negative regulation of neuron apoptotic process GO:0043524 9.81 BDNF NTRK1 NTRK2
6 positive regulation of ERK1 and ERK2 cascade GO:0070374 9.81 NTRK1 NTRK2 NTRK3 SRC
7 positive regulation of MAPK cascade GO:0043410 9.8 NTRK1 NTRK2 NTRK3
8 positive regulation of neuron projection development GO:0010976 9.79 NTRK1 NTRK2 NTRK3
9 axon guidance GO:0007411 9.78 BDNF GAB2 NTRK1 SRC
10 circadian rhythm GO:0007623 9.75 NTRK1 NTRK2 NTRK3
11 ephrin receptor signaling pathway GO:0048013 9.72 NTRK1 NTRK3 SRC
12 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.71 NTRK2 NTRK3 SRC
13 positive regulation of synapse assembly GO:0051965 9.71 BDNF NTRK1 NTRK2 NTRK3
14 negative regulation of apoptotic process GO:0043066 9.7 NTRK1 SRC STAT5B
15 activation of protein kinase B activity GO:0032148 9.68 NTRK3 SRC
16 peptidyl-tyrosine autophosphorylation GO:0038083 9.68 NTRK1 SRC
17 activation of phospholipase C activity GO:0007202 9.67 BDNF NTRK2
18 interleukin-7-mediated signaling pathway GO:0038111 9.67 STAT5A STAT5B
19 regulation of multicellular organism growth GO:0040014 9.67 STAT5A STAT5B
20 response to axon injury GO:0048678 9.66 NTRK1 NTRK3
21 JAK-STAT cascade GO:0007259 9.66 STAT5A STAT5B
22 response to electrical stimulus GO:0051602 9.65 NTRK1 SRC
23 myelination in peripheral nervous system GO:0022011 9.63 NTRK2 NTRK3
24 negative regulation of anoikis GO:2000811 9.62 NTRK2 SRC
25 interleukin-15-mediated signaling pathway GO:0035723 9.61 STAT5A STAT5B
26 cellular response to nerve growth factor stimulus GO:1990090 9.61 NTRK1 NTRK2 NTRK3
27 JAK-STAT cascade involved in growth hormone signaling pathway GO:0060397 9.6 STAT5A STAT5B
28 nerve growth factor signaling pathway GO:0038180 9.59 BDNF NTRK1
29 interleukin-2-mediated signaling pathway GO:0038110 9.58 STAT5A STAT5B
30 interleukin-9-mediated signaling pathway GO:0038113 9.57 STAT5A STAT5B
31 neuronal action potential propagation GO:0019227 9.56 NTRK2 NTRK3
32 positive regulation of non-membrane spanning protein tyrosine kinase activity GO:1903997 9.54 BDNF NTRK2 SRC
33 mechanoreceptor differentiation GO:0042490 9.5 NTRK1 NTRK2 NTRK3
34 taurine metabolic process GO:0019530 9.49 STAT5A STAT5B
35 brain-derived neurotrophic factor receptor signaling pathway GO:0031547 9.46 BDNF NTRK2
36 neurotrophin TRK receptor signaling pathway GO:0048011 9.46 BDNF NTRK1 NTRK2 SRC
37 neurotrophin signaling pathway GO:0038179 9.43 NTRK1 NTRK2 NTRK3
38 peptidyl-tyrosine phosphorylation GO:0018108 9.43 NTRK1 NTRK2 NTRK3 SRC STAT5A STAT5B
39 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.1 BDNF GAB2 NTRK1 NTRK2 NTRK3 SRC
40 cell differentiation GO:0030154 10.04 ETV6 NTRK1 NTRK2 NTRK3 SRC

Molecular functions related to Cellular Congenital Mesoblastic Nephroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein kinase activity GO:0004672 9.67 NTRK1 NTRK2 NTRK3 SRC
2 transmembrane receptor protein tyrosine kinase activity GO:0004714 9.43 NTRK1 NTRK2 NTRK3
3 neurotrophin binding GO:0043121 9.33 NTRK1 NTRK2 NTRK3
4 GPI-linked ephrin receptor activity GO:0005004 9.32 NTRK1 NTRK3
5 neurotrophin receptor activity GO:0005030 9.13 NTRK1 NTRK2 NTRK3
6 protein tyrosine kinase activity GO:0004713 9.1 NTRK1 NTRK2 NTRK3 SRC STAT5A STAT5B

Sources for Cellular Congenital Mesoblastic Nephroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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