MCID: CLL010
MIFTS: 24

Cellular Ependymoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Cellular Ependymoma

MalaCards integrated aliases for Cellular Ependymoma:

Name: Cellular Ependymoma 12 15 72

Classifications:



External Ids:

Disease Ontology 12 DOID:5500
MeSH 44 D004806
NCIt 50 C4713 C4714
SNOMED-CT 68 57706008
UMLS 72 C1384403

Summaries for Cellular Ependymoma

MalaCards based summary : Cellular Ependymoma is related to clear cell ependymoma and ependymoma. An important gene associated with Cellular Ependymoma is SYP (Synaptophysin), and among its related pathways/superpathways is Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Cisplatin and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include spinal cord.

Related Diseases for Cellular Ependymoma

Diseases related to Cellular Ependymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 121)
# Related Disease Score Top Affiliating Genes
1 clear cell ependymoma 32.6 SYP GFAP
2 ependymoma 31.9 SYP RELA GFAP
3 benign ependymoma 30.1 SYP GFAP
4 hydrocephalus 29.6 SYP GFAP
5 ureter small cell carcinoma 10.2 SYP CHGA
6 small cell carcinoma 10.2 SYP CHGA
7 esophageal neuroendocrine tumor 10.2 SYP CHGA
8 neuroendocrine tumor 10.2 SYP CHGA
9 urinary bladder small cell neuroendocrine carcinoma 10.2 SYP CHGA
10 ovarian large-cell neuroendocrine carcinoma 10.2 SYP CHGA
11 auditory system cancer 10.2 SYP CHGA
12 acinar cell cystadenocarcinoma 10.2 SYP CHGA
13 primary hepatic neuroendocrine carcinoma 10.2 SYP CHGA
14 peritoneal serous adenocarcinoma 10.2 SYP CHGA
15 small cell carcinoma of the bladder 10.2 SYP CHGA
16 gastrointestinal neuroendocrine tumor 10.2 SYP CHGA
17 atypical follicular adenoma 10.2 SYP CHGA
18 gallbladder small cell carcinoma 10.2 SYP CHGA
19 pulmonary large cell neuroendocrine carcinoma 10.2 SYP CHGA
20 large cell neuroendocrine carcinoma 10.2 SYP CHGA
21 olfactory groove meningioma 10.2 SYP CHGA
22 cauda equina neoplasm 10.2 SYP CHGA
23 conventional angiosarcoma 10.2 SYP CHGA
24 pancreatic serous cystadenoma 10.2 SYP CHGA
25 cystadenoma 10.2 SYP CHGA
26 olfactory nerve neoplasm 10.2 SYP CHGA
27 nodular ganglioneuroblastoma 10.2 SYP CHGA
28 autonomic nervous system benign neoplasm 10.2 SYP CHGA
29 pulmonary sclerosing hemangioma 10.2 SYP CHGA
30 sclerosing hemangioma 10.2 SYP CHGA
31 hemangioma 10.2 SYP CHGA
32 pancreatoblastoma 10.2 SYP CHGA
33 gastric small cell carcinoma 10.2 SYP CHGA
34 anterior cranial fossa meningioma 10.2 SYP CHGA
35 respiratory system benign neoplasm 10.2 SYP CHGA
36 carcinoid tumors, intestinal 10.2 SYP CHGA
37 gastric squamous cell carcinoma 10.2 SYP CHGA
38 non-functioning pancreatic endocrine tumor 10.2 SYP CHGA
39 pulmonary blastoma 10.2 SYP CHGA
40 carcinoid syndrome 10.2 SYP CHGA
41 cervix small cell carcinoma 10.2 SYP CHGA
42 horseshoe kidney 10.2 SYP CHGA
43 granulosa cell tumor of the ovary 10.1 SYP CHGA
44 cranial nerve malignant neoplasm 10.1 SYP CHGA
45 mixed ductal-endocrine carcinoma 10.1 SYP CHGA
46 gastric tubular adenocarcinoma 10.1 SYP CHGA
47 tubular adenocarcinoma 10.1 SYP CHGA
48 olfactory neuroblastoma 10.1 SYP CHGA
49 malignant pheochromocytoma 10.1 SYP CHGA
50 lung benign neoplasm 10.1 SYP CHGA

Graphical network of the top 20 diseases related to Cellular Ependymoma:



Diseases related to Cellular Ependymoma

Symptoms & Phenotypes for Cellular Ependymoma

Drugs & Therapeutics for Cellular Ependymoma

Drugs for Cellular Ependymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 19)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cisplatin Approved Phase 3 15663-27-1 84093 441203 2767
2
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
3
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
4
Etoposide Approved Phase 3 33419-42-0 36462
5
Carboplatin Approved Phase 3 41575-94-4 10339178 498142 38904
6
Emodepside Investigational, Vet_approved Phase 3 155030-63-0
7 Alkylating Agents Phase 3
8 Antineoplastic Agents, Phytogenic Phase 3
9 Tubulin Modulators Phase 3
10 Immunosuppressive Agents Phase 3
11 Topoisomerase Inhibitors Phase 3
12 Keratolytic Agents Phase 3
13 Dermatologic Agents Phase 3
14 Podophyllotoxin Phase 3 518-28-5
15 Antimitotic Agents Phase 3
16 Immunologic Factors Phase 3
17 Antirheumatic Agents Phase 3
18 Antineoplastic Agents, Alkylating Phase 3
19 Etoposide phosphate Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase III Randomized Trial of Post-Radiation Chemotherapy in Patients With Newly Diagnosed Ependymoma Ages 1 to 21 Years Recruiting NCT01096368 Phase 3 Carboplatin;Cisplatin;Cyclophosphamide;Etoposide;Vincristine Sulfate Liposome

Search NIH Clinical Center for Cellular Ependymoma

Genetic Tests for Cellular Ependymoma

Anatomical Context for Cellular Ependymoma

MalaCards organs/tissues related to Cellular Ependymoma:

41
Spinal Cord

Publications for Cellular Ependymoma

Articles related to Cellular Ependymoma:

(show all 18)
# Title Authors PMID Year
1
Factors associated with postoperative outcomes in patients with intramedullary Grade II ependymomas: A Systematic review and meta-analysis. 38
31232977 2019
2
MRI Characteristics of Spinal Ependymoma in WHO Grade II: A Review of 59 Cases. 38
29189641 2018
3
A Simplified Overview of World Health Organization Classification Update of Central Nervous System Tumors 2016. 38
29204027 2017
4
Spontaneous Hemorrhage of a Spinal Ependymoma in the Filum Terminale Presenting with Acute Cauda Equina Syndrome: Case Report. 38
28664006 2016
5
Infantile holocord cellular ependymoma with communicating hydrocephalus: unusual presentation of a rare case. 38
23512254 2014
6
PET findings of intramedullary tumors of the spinal cord using [18F] FDG and [11C] methionine. 38
23275592 2013
7
'Serpent in the spine': a case of giant spinal ependymoma of cervicothoracic spine. 38
22739334 2012
8
Supratentorial ependymoma in children: to observe or to treat following gross total resection? 38
21370439 2012
9
Fourth ventricle neurocytoma with lipomatous and ependymal differentiation. 38
15627205 2005
10
Histological spectrum of ependymomas and correlation of p53 and Ki-67 expression with ependymoma grade and subtype. 38
15318011 2004
11
[Supratentorial ectopic ependymoma: a case report]. 38
10629896 1999
12
Mucin-secreting cellular ependymoma: a light and electron microscopy study. 38
10582269 1999
13
Familial gliomas : a case report. 38
10402341 1999
14
An unusual variant of ependymoma with extensive tumor cell vacuolization. 38
9083565 1997
15
Malignant primitive neuroepithelial tumour of soft tissues mimicking a cellular ependymoma. 38
1495851 1992
16
[Histopathological changes of the human spinal cord--with special reference to latent lesions found in spinal cords of the aged]. 38
6655321 1983
17
Symptomatic subependymoma. Report of 21 cases with review of the literature. 38
712391 1978
18
[Nodular tumor of the filum terminale: cellular ependymoma]. 38
1200431 1975

Variations for Cellular Ependymoma

Expression for Cellular Ependymoma

Search GEO for disease gene expression data for Cellular Ependymoma.

Pathways for Cellular Ependymoma

Pathways related to Cellular Ependymoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.52 SYP GFAP

GO Terms for Cellular Ependymoma

Molecular functions related to Cellular Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 identical protein binding GO:0042802 8.8 SYP RELA GFAP

Sources for Cellular Ependymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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