MCID: CLL010
MIFTS: 30

Cellular Ependymoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Cellular Ependymoma

MalaCards integrated aliases for Cellular Ependymoma:

Name: Cellular Ependymoma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5500
MeSH 44 D004806
NCIt 50 C4713 C4714
SNOMED-CT 68 57706008
UMLS 73 C1384403

Summaries for Cellular Ependymoma

MalaCards based summary : Cellular Ependymoma is related to ependymoma and clear cell ependymoma. An important gene associated with Cellular Ependymoma is SYP (Synaptophysin), and among its related pathways/superpathways are Neural Stem Cell Differentiation Pathways and Lineage-specific Markers and Mitophagy - animal. The drugs Vincristine and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include lung, brain and kidney.

Related Diseases for Cellular Ependymoma

Diseases related to Cellular Ependymoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 188)
# Related Disease Score Top Affiliating Genes
1 ependymoma 32.6 GFAP RELA SYP
2 clear cell ependymoma 32.1 GFAP SYP
3 hydrocephalus 29.5 GFAP SYP TP53
4 dementia, lewy body 10.2 SMUG1 SYP
5 hemangioblastoma 10.2 GFAP SYP
6 desmoplastic infantile ganglioglioma 10.1 GFAP SYP
7 extraventricular neurocytoma 10.1 GFAP SYP
8 lung combined type small cell carcinoma 10.1 GFAP SYP
9 partial motor epilepsy 10.1 SMUG1 SYP
10 chiari malformation 10.1 GFAP SYP
11 dysembryoplastic neuroepithelial tumor 10.1 GFAP SYP
12 subependymal glioma 10.1 GFAP SYP
13 astroblastoma 10.1 GFAP SYP
14 paraganglioma 10.1 CHGA SYP
15 endocrine organ benign neoplasm 10.1 CHGA SYP
16 primary pigmented nodular adrenocortical disease 10.1 CHGA SYP
17 pineal gland cancer 10.1 GFAP SYP
18 melanotic neuroectodermal tumor 10.1 GFAP SYP
19 large cell carcinoma 10.1 CHGA SYP
20 benign ependymoma 10.1 GFAP SYP
21 mediastinal cancer 10.1 SMUG1 SYP
22 angiocentric glioma 10.1 GFAP SYP
23 obstructive hydrocephalus 10.1 GFAP SYP
24 medulloepithelioma 10.1 GFAP SYP
25 ureter small cell carcinoma 10.1 CHGA SYP
26 esophageal neuroendocrine tumor 10.1 CHGA SYP
27 urinary bladder small cell neuroendocrine carcinoma 10.1 CHGA SYP
28 ovarian large-cell neuroendocrine carcinoma 10.1 CHGA SYP
29 childhood oligodendroglioma 10.1 GFAP SYP
30 auditory system cancer 10.1 CHGA SYP
31 adenoma of the pancreas 10.1 CHGA SYP
32 acinar cell cystadenocarcinoma 10.1 CHGA SYP
33 pineoblastoma 10.1 GFAP SYP
34 peritoneal serous adenocarcinoma 10.1 CHGA SYP
35 primary hepatic neuroendocrine carcinoma 10.1 CHGA SYP
36 small cell carcinoma of the bladder 10.1 CHGA SYP
37 pulmonary large cell neuroendocrine carcinoma 10.1 CHGA SYP
38 large cell neuroendocrine carcinoma 10.1 CHGA SYP
39 cauda equina neoplasm 10.1 CHGA SYP
40 pancreatic serous cystadenoma 10.1 CHGA SYP
41 mandibular cancer 10.1 GFAP SMUG1
42 cystadenoma 10.1 CHGA SYP
43 conventional angiosarcoma 10.1 CHGA SYP
44 subependymal giant cell astrocytoma 10.1 GFAP SYP
45 olfactory nerve neoplasm 10.1 CHGA SYP
46 autonomic nervous system benign neoplasm 10.1 CHGA SYP
47 nodular ganglioneuroblastoma 10.1 CHGA SYP
48 pulmonary sclerosing hemangioma 10.1 CHGA SYP
49 sclerosing hemangioma 10.1 CHGA SYP
50 gastric small cell carcinoma 10.1 CHGA SYP

Graphical network of the top 20 diseases related to Cellular Ependymoma:



Diseases related to Cellular Ependymoma

Symptoms & Phenotypes for Cellular Ependymoma

Drugs & Therapeutics for Cellular Ependymoma

Drugs for Cellular Ependymoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 18)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Vincristine Approved, Investigational Phase 3 57-22-7, 2068-78-2 5978
2
Cyclophosphamide Approved, Investigational Phase 3 6055-19-2, 50-18-0 2907
3
Carboplatin Approved Phase 3 41575-94-4 10339178 38904 498142
4
Etoposide Approved Phase 3 33419-42-0 36462
5
Cisplatin Approved Phase 3 15663-27-1 2767 441203 84093
6 Antineoplastic Agents, Alkylating Phase 3
7 Keratolytic Agents Phase 3
8 Alkylating Agents Phase 3
9 Antineoplastic Agents, Phytogenic Phase 3
10 Podophyllotoxin Phase 3 518-28-5
11 Immunologic Factors Phase 3,Phase 1
12 Antirheumatic Agents Phase 3
13 Antimitotic Agents Phase 3
14 Etoposide phosphate Phase 3
15 Topoisomerase Inhibitors Phase 3
16 Immunosuppressive Agents Phase 3
17 Dermatologic Agents Phase 3
18 Vaccines Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Maintenance Chemotherapy or Observation Following Induction Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Ependymoma Recruiting NCT01096368 Phase 3 Carboplatin;Cisplatin;Cyclophosphamide;Etoposide;Vincristine Sulfate Liposome
2 Trial of Heat Shock Protein Peptide Complex-96 (HSPPC-96) Vaccine Recruiting NCT02722512 Phase 1

Search NIH Clinical Center for Cellular Ependymoma

Genetic Tests for Cellular Ependymoma

Anatomical Context for Cellular Ependymoma

MalaCards organs/tissues related to Cellular Ependymoma:

41
Lung, Brain, Kidney, Spinal Cord, Cervix, Thymus, Cerebellum

Publications for Cellular Ependymoma

Articles related to Cellular Ependymoma:

# Title Authors Year
1
Infantile holocord cellular ependymoma with communicating hydrocephalus: unusual presentation of a rare case. ( 23512254 )
2014
2
Mucin-secreting cellular ependymoma: a light and electron microscopy study. ( 10582269 )
1999
3
Malignant primitive neuroepithelial tumour of soft tissues mimicking a cellular ependymoma. ( 1495851 )
1992

Variations for Cellular Ependymoma

Expression for Cellular Ependymoma

Search GEO for disease gene expression data for Cellular Ependymoma.

Pathways for Cellular Ependymoma

Pathways related to Cellular Ependymoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.15 GFAP SYP
2 10.97 RELA TP53
3
Show member pathways
10.69 RELA TP53
4 10.27 RELA TP53

GO Terms for Cellular Ependymoma

Biological processes related to Cellular Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 base-excision repair GO:0006284 8.96 SMUG1 TP53
2 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 8.62 RELA TP53

Molecular functions related to Cellular Ependymoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein self-association GO:0043621 8.96 SYP TP53
2 identical protein binding GO:0042802 8.92 GFAP RELA SYP TP53

Sources for Cellular Ependymoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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