MCID: CLL005
MIFTS: 30

Cellular Leiomyoma

Categories: Cancer diseases

Aliases & Classifications for Cellular Leiomyoma

MalaCards integrated aliases for Cellular Leiomyoma:

Name: Cellular Leiomyoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:5139
NCIt 51 C4256
SNOMED-CT 69 90955001
UMLS 74 C0334477

Summaries for Cellular Leiomyoma

Disease Ontology : 12 A leiomyoma that is a morphological variant of leiomyoma and is characterized by increased cellularity, no atypia and no mitotic figures.

MalaCards based summary : Cellular Leiomyoma is related to leiomyoma and endometrial stromal sarcoma. An important gene associated with Cellular Leiomyoma is CCL11 (C-C Motif Chemokine Ligand 11), and among its related pathways/superpathways are Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions and Interleukin-4 and 13 signaling. The drugs Leuprolide and Imidacloprid have been mentioned in the context of this disorder. Affiliated tissues include uterus and smooth muscle.

Related Diseases for Cellular Leiomyoma

Graphical network of the top 20 diseases related to Cellular Leiomyoma:



Diseases related to Cellular Leiomyoma

Symptoms & Phenotypes for Cellular Leiomyoma

Drugs & Therapeutics for Cellular Leiomyoma

Drugs for Cellular Leiomyoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Leuprolide Approved, Investigational Phase 4 53714-56-0 657181 3911
2
Imidacloprid Vet_approved Phase 4 105827-78-9 86418
3 Contraceptive Agents Phase 4
4 Ulipristal acetate Phase 4 126784-99-4
5 Antineoplastic Agents, Hormonal Phase 4
6 Fertility Agents Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Ulipristal Acetate for the Preoperative Management of Hypoechoic Cellular Leiomyomas Unknown status NCT02361905 Phase 4 ulipristal acetate;Leuprolide acetate

Search NIH Clinical Center for Cellular Leiomyoma

Genetic Tests for Cellular Leiomyoma

Anatomical Context for Cellular Leiomyoma

MalaCards organs/tissues related to Cellular Leiomyoma:

42
Uterus, Smooth Muscle

Publications for Cellular Leiomyoma

Articles related to Cellular Leiomyoma:

(show all 17)
# Title Authors Year
1
Massive Broad Ligament Cellular Leiomyoma with Cystic Change: A Diagnostic Dilemma. ( 27190813 )
2016
2
Prevalence of cellular leiomyoma and partially cellular leiomyoma in postoperative samples - analysis of 384 cases. ( 27723066 )
2016
3
Recurrent cellular leiomyoma 10 years after total abdominal hysterectomy. ( 25692711 )
2015
4
Pelvic Retroperitoneal Cellular Leiomyoma: A Case Report. ( 26817226 )
2015
5
Cellular leiomyoma versus endometrial stromal tumor: A pathologists' dilemma. ( 25861206 )
2015
6
Cellular leiomyoma with necrosis and mucinous degeneration presenting as pseudo-Meigs' syndrome with elevated CA125. ( 25891047 )
2015
7
Immunolocalization of VEGF, VEGF receptors, EGF-R and Ki-67 in leiomyoma, cellular leiomyoma and leiomyosarcoma. ( 20106509 )
2011
8
Highly cellular leiomyoma mimics a malignant small round-cell tumor: a diagnostic dilemma on frozen sections. ( 20708530 )
2010
9
[Study of the mechanism of mast cell increase in cellular leiomyoma of uterus]. ( 17697600 )
2007
10
Cellular leiomyoma of the nasal cavity: findings of CT and MR imaging. ( 15956493 )
2005
11
Immunohistochemical markers in differential diagnosis of endometrial stromal sarcoma and cellular leiomyoma. ( 14751141 )
2004
12
[Mast cells in cellular leiomyoma and endometrial stromal sarcoma of the uterus]. ( 15196440 )
2004
13
h-Caldesmon, a novel smooth muscle-specific antibody, distinguishes between cellular leiomyoma and endometrial stromal sarcoma. ( 11176075 )
2001
14
Immunohistochemical distinction of endometrial stromal sarcoma and cellular leiomyoma. ( 11396634 )
2001
15
Cellular leiomyoma mimicking endometrial stromal neoplasm in association with GnRH agonist goserelin. ( 10064405 )
1999
16
Implantation site on a cellular leiomyoma: a light microscopic and immunohistochemical study. ( 2807023 )
1989
17
A comparative ultrastuctural study of leiomyosarcoma, cellular leiomyoma, and leiomyoma of the uterus. ( 5111736 )
1971

Variations for Cellular Leiomyoma

Expression for Cellular Leiomyoma

Search GEO for disease gene expression data for Cellular Leiomyoma.

Pathways for Cellular Leiomyoma

GO Terms for Cellular Leiomyoma

Cellular components related to Cellular Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell GO:0005623 8.62 CCL11 CCL2

Biological processes related to Cellular Leiomyoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 immune response GO:0006955 9.67 BMP6 CCL11 CCL2
2 regulation of signaling receptor activity GO:0010469 9.61 BMP6 CCL11 CCL2
3 kidney development GO:0001822 9.52 BMP6 MME
4 cellular response to interferon-gamma GO:0071346 9.51 CCL11 CCL2
5 inflammatory response GO:0006954 9.5 BMP6 CCL11 CCL2
6 neutrophil chemotaxis GO:0030593 9.48 CCL11 CCL2
7 cellular response to interleukin-1 GO:0071347 9.46 CCL11 CCL2
8 chemokine-mediated signaling pathway GO:0070098 9.4 CCL11 CCL2
9 positive regulation of endothelial cell proliferation GO:0001938 9.37 BMP6 CCL11
10 monocyte chemotaxis GO:0002548 9.26 CCL11 CCL2
11 lymphocyte chemotaxis GO:0048247 9.16 CCL11 CCL2
12 eosinophil chemotaxis GO:0048245 8.96 CCL11 CCL2
13 cytoskeleton organization GO:0007010 8.8 CCL11 CCL2 DES

Molecular functions related to Cellular Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chemokine activity GO:0008009 9.16 CCL11 CCL2
2 CCR chemokine receptor binding GO:0048020 8.96 CCL11 CCL2
3 cytokine activity GO:0005125 8.8 BMP6 CCL11 CCL2

Sources for Cellular Leiomyoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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