MCID: CLL005
MIFTS: 28

Cellular Leiomyoma

Categories: Cancer diseases

Aliases & Classifications for Cellular Leiomyoma

MalaCards integrated aliases for Cellular Leiomyoma:

Name: Cellular Leiomyoma 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:5139
NCIt 50 C4256
SNOMED-CT 67 90955001
UMLS 70 C0334477

Summaries for Cellular Leiomyoma

Disease Ontology : 12 A leiomyoma that is a morphological variant of leiomyoma and is characterized by increased cellularity, no atypia and no mitotic figures.

MalaCards based summary : Cellular Leiomyoma is related to leiomyoma and mixed endometrial stromal and smooth muscle tumor. An important gene associated with Cellular Leiomyoma is CCL11 (C-C Motif Chemokine Ligand 11), and among its related pathways/superpathways are A-beta Pathways: Uptake and Degradation and G-protein signaling_Rap2B regulation pathway. The drugs Leuprolide and Imidacloprid have been mentioned in the context of this disorder. Affiliated tissues include smooth muscle, uterus and breast.

Related Diseases for Cellular Leiomyoma

Diseases related to Cellular Leiomyoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 91)
# Related Disease Score Top Affiliating Genes
1 leiomyoma 30.2 PCNA MME MED12 DES
2 mixed endometrial stromal and smooth muscle tumor 29.9 MME CALD1
3 mesenchymal cell neoplasm 29.6 MME CALD1
4 endometrial stromal tumor 29.1 SUZ12 MME JAZF1 CALD1
5 myoma 29.1 MUC16 MME MED12 CALD1
6 smooth muscle tumor 28.9 MME MED12 DES CCL11 CALD1
7 endometrial stromal sarcoma 28.5 SUZ12 PCNA MME JAZF1 DES CCL2
8 uterine corpus apoplectic leiomyoma 11.4
9 uterine corpus cellular leiomyoma 11.3
10 chronic asthma 10.3 CCL11 BMP6
11 papillary conjunctivitis 10.2 CCL2 CCL11
12 chronic eosinophilic pneumonia 10.2 CCL2 CCL11
13 leiomyosarcoma 10.2
14 lymphangiomatosis 10.2 PCNA DES
15 inflammatory leiomyosarcoma 10.2 DES CALD1
16 juvenile nasopharyngeal angiofibroma 10.2 PCNA BMP6
17 malignant fibrous histiocytoma of bone 10.2 DES CALD1
18 cutaneous leiomyosarcoma 10.2 DES CALD1
19 malignant mesenchymoma 10.1 DES CALD1
20 angiolipoma 10.1 DES CALD1
21 glomangioma 10.1 DES CALD1
22 adult cystic nephroma 10.1 MME DES
23 nephroma 10.1 MME DES
24 sarcoma 10.1
25 spindle cell sarcoma 10.1
26 myofibroma 10.1 DES CALD1
27 cystadenofibroma 10.1 MUC16 MME
28 adenofibroma 10.1 MUC16 MME
29 keratoconjunctivitis 10.1 MUC16 CCL2 CCL11
30 pleomorphic liposarcoma 10.1 DES CALD1
31 conjunctivitis 10.1 MUC16 CCL2 CCL11
32 vaginal endometrial stromal tumor 10.1 MME CALD1
33 diabetic angiopathy 10.1 CCL2 BMP6
34 pseudosarcomatous fibromatosis 10.1 DES CALD1
35 fallopian tube leiomyoma 10.1 MME CALD1
36 urethra leiomyoma 10.1 MME CALD1
37 fallopian tube benign neoplasm 10.1 MME CALD1
38 breast myofibroblastoma 10.1 MME CALD1
39 radiculopathy 10.1 CCL2 CCL11
40 fallopian tube endometrioid adenocarcinoma 10.1 MUC16 MME
41 subareolar duct papillomatosis 10.1 MME CALD1
42 lung combined type small cell carcinoma 10.1 MME CALD1
43 cervical mucinous adenocarcinoma 10.1 MME CALD1
44 nipple benign neoplasm 10.1 MME CALD1
45 sarcomatoid squamous cell skin carcinoma 10.1 MME CALD1
46 uterus perivascular epithelioid cell tumor 10.1 MME CALD1
47 vulvar leiomyoma 10.1 MME CALD1
48 endometriosis 10.1
49 infantile myofibromatosis 10.0 DES CALD1
50 cutaneous fibrous histiocytoma 10.0 MME DES

Graphical network of the top 20 diseases related to Cellular Leiomyoma:



Diseases related to Cellular Leiomyoma

Symptoms & Phenotypes for Cellular Leiomyoma

Drugs & Therapeutics for Cellular Leiomyoma

Drugs for Cellular Leiomyoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Leuprolide Approved, Investigational Phase 4 53714-56-0 3911 657181
2
Imidacloprid Vet_approved Phase 4 105827-78-9 86418
3 Contraceptive Agents Phase 4
4 Antineoplastic Agents, Hormonal Phase 4
5 Ulipristal acetate Phase 4 126784-99-4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Advantages of Ulipristal Acetate for the Preoperative Treatment of Hypoechoic Cellular Leiomyomas Unknown status NCT02361905 Phase 4 ulipristal acetate;Leuprolide acetate

Search NIH Clinical Center for Cellular Leiomyoma

Genetic Tests for Cellular Leiomyoma

Anatomical Context for Cellular Leiomyoma

MalaCards organs/tissues related to Cellular Leiomyoma:

40
Smooth Muscle, Uterus, Breast, Small Intestine, Bone, Lung, Skin

Publications for Cellular Leiomyoma

Articles related to Cellular Leiomyoma:

(show top 50) (show all 105)
# Title Authors PMID Year
1
Unmasking the great masqueraders: Concurrent isolated large cecal endometrioma and solitary extra-uterine retroperitoneal cellular leiomyoma - A case report with review of literature. 61
33636403 2021
2
Criteria for risk stratification of vulvar and vaginal smooth muscle tumors: a follow-up study with application to leiomyoma variants, smooth muscle tumors of uncertain malignant potential, and leiomyosarcomas. 61
32687944 2020
3
Low-Grade Endometrial Stromal Sarcoma Diagnosed 8 Years After Hysterectomy With Morcellation. 61
32649495 2020
4
Gene fusions characterize a subset of uterine cellular leiomyomas. 61
32677742 2020
5
STMN1 and MKI67 Are Upregulated in Uterine Leiomyosarcoma and Are Potential Biomarkers for its Diagnosis. 61
32425177 2020
6
Leiomyoma with KAT6B-KANSL1 fusion: case report of a rapidly enlarging uterine mass in a postmenopausal woman. 61
31027501 2019
7
Leiomyoma: Its Variants And Secondary Changes A Five-Year Study. 61
31094115 2019
8
High expression of EZH2 as a marker for the differential diagnosis of malignant and benign myogenic tumors. 61
30120321 2018
9
The selected biomarker analysis in 5 types of uterine smooth muscle tumors. 61
29258902 2018
10
Expression and prognostic value of lactate dehydrogenase-A and -D subunits in human uterine myoma and uterine sarcoma. 61
29620641 2018
11
[Application of dynamic-contrast enhanced magnetic resonance pharmacokinetic models in differential diagnosis of cellular uterine leiomyoma]. 61
29488716 2017
12
Massive Broad Ligament Cellular Leiomyoma with Cystic Change: A Diagnostic Dilemma. 61
27190813 2016
13
Leiomyomatosis peritonealis disseminata in postmenopausal women: a case report with review of literature. 61
27785109 2016
14
Prevalence of cellular leiomyoma and partially cellular leiomyoma in postoperative samples - analysis of 384 cases. 61
27723066 2016
15
Practical issues related to uterine pathology: endometrial stromal tumors. 61
26715176 2016
16
Unaware of a large leiomyoma: A case report with respect to unusual symptoms of large leiomyomas. 61
26904195 2015
17
Malignant presentation of uterine lymphangioleiomyomatosis. 61
26522119 2015
18
Pelvic Retroperitoneal Cellular Leiomyoma: A Case Report. 61
26817226 2015
19
[Multiple primary neoplasms with renal neurilemmoma: a case report and literature review]. 61
26284415 2015
20
Cellular leiomyoma with necrosis and mucinous degeneration presenting as pseudo-Meigs' syndrome with elevated CA125. 61
25891047 2015
21
The role of hypoxia related angiogenesis in uterine smooth muscle tumors. 61
25225843 2015
22
Recurrent cellular leiomyoma 10 years after total abdominal hysterectomy. 61
25692711 2015
23
Cellular leiomyoma versus endometrial stromal tumor: A pathologists' dilemma. 61
25861206 2015
24
Fibromyxoid variant of endometrial stromal sarcoma with atypical bizarre nuclei. 61
26045860 2015
25
An immunohistochemical analysis of stathmin 1 expression in uterine smooth muscle tumors: differential expression in leiomyosarcomas and leiomyomas. 61
26045786 2015
26
Molecular analyses of 6 different types of uterine smooth muscle tumors: Emphasis in atypical leiomyoma. 61
24986214 2014
27
[Analysis of the risk factors for postoperative residue, relapse following myomectomy]. 61
25354860 2014
28
Cellular mesenchymal tumors of the uterus: a review emphasizing recent observations. 61
24901397 2014
29
Spontaneous rupture of tubal leiomyoma causing haemoperitoneum. 61
24906284 2014
30
Targeted development of specific biomarkers of endometrial stromal cell differentiation using bioinformatics: the IFITM1 model. 61
24072182 2014
31
Cytogenetically normal uterine leiomyomas without MED12-mutations - a source to identify unknown mechanisms of the development of uterine smooth muscle tumors. 61
25506394 2014
32
Diagnosis of endometrial stromal tumors: a clinicopathologic study of 25 biopsy specimens with identification of problematic areas. 61
24343747 2014
33
Expression and intracellular localization of ACA and TRA-1-81 in smooth muscle cell tumors. 61
24143384 2013
34
Cell cycle regulatory markers in uterine atypical leiomyoma and leiomyosarcoma: immunohistochemical study of 68 cases with clinical follow-up. 61
23552380 2013
35
Unusual types of smooth muscle tumors of uterine corpus: case reports and literature review. 61
23567300 2013
36
[Highly cellular leiomyoma of uterus with diffuse plexiform pattern resembling sex-cord tumor: report of a case]. 61
22932415 2012
37
Leiomyoma cellulare in the broad ligament of the uterus--case report and review of literature. 61
22712264 2012
38
Peritoneal dissemination complicating morcellation of uterine mesenchymal neoplasms. 61
23189178 2012
39
Late presentation of metastatic smooth muscle neoplasm of the uterus with low malignant potential. 61
22355470 2012
40
Immunolocalization of VEGF, VEGF receptors, EGF-R and Ki-67 in leiomyoma, cellular leiomyoma and leiomyosarcoma. 61
20106509 2011
41
Benign metastasizing leiomyoma: metastasis to rib and vertebra. 61
21353035 2011
42
Highly cellular leiomyoma mimics a malignant small round-cell tumor: a diagnostic dilemma on frozen sections. 61
20708530 2010
43
Uterine smooth muscle tumors other than the ordinary leiomyomas and leiomyosarcomas: a review of selected variants with emphasis on recent advances and unusual morphology that may cause concern for malignancy. 61
20179432 2010
44
Dermatofibrosarcoma protuberans of the vulva: a clinicopathologic and immunohistochemical study of 13 cases. 61
20139758 2010
45
Molecular and immunohistochemical evidence for the origin of uterine leiomyosarcomas from associated leiomyoma and symplastic leiomyoma-like areas. 61
19633649 2009
46
Transcervical microwave myolysis for uterine myomas assisted by transvaginal ultrasonic guidance. 61
19215562 2009
47
Hyaline globules in paucicellular leiomyomas of the gastrointestinal tract are distinct from skeinoid fibers and represent degenerating smooth muscle cells. 61
19216034 2009
48
[Immunohistochemical study of endometrial stromal sarcoma and smooth-muscle tumors of the uterus]. 61
18565690 2008
49
Expression of chemokines CCL5 and CCL11 by smooth muscle tumor cells of the uterus and its possible role in the recruitment of mast cells. 61
17368523 2007
50
[Study of the mechanism of mast cell increase in cellular leiomyoma of uterus]. 61
17697600 2007

Variations for Cellular Leiomyoma

Expression for Cellular Leiomyoma

Search GEO for disease gene expression data for Cellular Leiomyoma.

Pathways for Cellular Leiomyoma

Pathways related to Cellular Leiomyoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.66 MME CCL2
2 10.16 DES CCL2 CCL11 BMP6
3 9.9 CCL2 CCL11

GO Terms for Cellular Leiomyoma

Biological processes related to Cellular Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to retinoic acid GO:0032526 9.37 SUZ12 BMP6
2 monocyte chemotaxis GO:0002548 9.32 CCL2 CCL11
3 lymphocyte chemotaxis GO:0048247 9.26 CCL2 CCL11
4 spinal cord development GO:0021510 9.16 SUZ12 MED12
5 cytoskeleton organization GO:0007010 9.13 DES CCL2 CCL11
6 eosinophil chemotaxis GO:0048245 8.62 CCL2 CCL11

Molecular functions related to Cellular Leiomyoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.13 CCL2 CCL11 BMP6
2 CCR chemokine receptor binding GO:0048020 8.62 CCL2 CCL11

Sources for Cellular Leiomyoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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