MCID: CLL004
MIFTS: 30

Cellular Myxoid Liposarcoma

Categories: Cancer diseases

Aliases & Classifications for Cellular Myxoid Liposarcoma

MalaCards integrated aliases for Cellular Myxoid Liposarcoma:

Name: Cellular Myxoid Liposarcoma 12 15
Round Cell Liposarcoma 12 17 70

Classifications:



External Ids:

Disease Ontology 12 DOID:5692
NCIt 50 C4252
SNOMED-CT 67 43296007
UMLS 70 C0334471

Summaries for Cellular Myxoid Liposarcoma

MalaCards based summary : Cellular Myxoid Liposarcoma, also known as round cell liposarcoma, is related to mixed liposarcoma and myxoid liposarcoma. An important gene associated with Cellular Myxoid Liposarcoma is FUS (FUS RNA Binding Protein), and among its related pathways/superpathways is Transcriptional misregulation in cancer. The drugs Dexamethasone and Dexamethasone acetate have been mentioned in the context of this disorder. Affiliated tissues include t cells, kidney and bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Cellular Myxoid Liposarcoma

Diseases related to Cellular Myxoid Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 110)
# Related Disease Score Top Affiliating Genes
1 mixed liposarcoma 32.1 MDM2 FUS DDIT3 CDK4
2 myxoid liposarcoma 31.0 SSX2 SSX1 SS18 MDM2 FUS EWSR1
3 liposarcoma 30.9 PIK3CA MDM2 FUS EWSR1 DDIT3 CDK4
4 pleomorphic lipoma 30.6 SERPINA3 MDM2 CDK4
5 lipoblastoma 30.4 MDM2 CDK4
6 spindle cell lipoma 30.4 MDM2 CDK4
7 lipomatosis, multiple 30.1 SERPINA3 MDM2 FUS EWSR1 DDIT3 CDK4
8 chondrosarcoma 30.1 SERPINA3 MDM2 EWSR1 CDK4
9 connective tissue benign neoplasm 30.1 SERPINA3 MDM2 EWSR1 CDK4
10 extraosseous chondrosarcoma 29.8 SSX2 SS18 FUS EWSR1
11 spindle cell sarcoma 29.3 SSX2 SSX1 SS18 SERPINA3 MDM2 EWSR1
12 myxofibrosarcoma 29.3 SSX2 SS18 SERPINA3 MDM2 FUS EWSR1
13 chondrosarcoma, extraskeletal myxoid 29.2 SSX2 SSX1 SS18 FUS EWSR1 DDIT3
14 dedifferentiated liposarcoma 28.9 YEATS4 SSX2 SS18 SERPINA3 MDM2 FUS
15 sarcoma, synovial 28.7 SSX2 SSX1 SS18 SERPINA3 MDM2 FUS
16 pleomorphic liposarcoma 28.7 YEATS4 SSX2 SS18 SERPINA3 MDM2 FUS
17 sarcoma 28.7 SSX2 SSX1 SS18 PIK3CA MDM2 FUS
18 well-differentiated liposarcoma 28.5 YEATS4 SSX2 SSX1 SS18 SERPINA3 MDM2
19 soft tissue sarcoma 10.4
20 sclerosing liposarcoma 10.3 MDM2 FUS
21 extraskeletal chondroma 10.3 SERPINA3 EWSR1
22 ring chromosome 7 10.3 MDM2 CDK4
23 mediastinum liposarcoma 10.3 MDM2 CDK4
24 gastric liposarcoma 10.3 MDM2 CDK4
25 infiltrating lipoma 10.3 MDM2 CDK4
26 diffuse lipomatosis 10.3 MDM2 CDK4
27 liposarcoma of bone 10.3 MDM2 CDK4
28 paratesticular lipoma 10.3 MDM2 CDK4
29 lipoma of spermatic cord 10.3 MDM2 CDK4
30 adult liposarcoma 10.3 MDM2 CDK4
31 juxtacortical osteosarcoma 10.3 MDM2 CDK4
32 infiltrating angiolipoma 10.3 MDM2 CDK4
33 fibrous histiocytoma 10.3 SERPINA3 FUS EWSR1
34 peripheral osteosarcoma 10.3 MDM2 CDK4
35 hereditary melanoma 10.3 MDM2 CDK4
36 heart cancer 10.2 SERPINA3 MDM2
37 pediatric fibrosarcoma 10.2 SERPINA3 EWSR1
38 myositis ossificans 10.2 MDM2 CDK4
39 spindle cell liposarcoma 10.2 MDM2 DDIT3 CDK4
40 ischemic fasciitis 10.2 MDM2 CDK4
41 undifferentiated embryonal sarcoma of the liver 10.2 SERPINA3 MDM2 CDK4
42 embryonal sarcoma 10.2 SERPINA3 MDM2 CDK4
43 embryonal rhabdomyosarcoma 10.2 MDM2 EWSR1 CDK4
44 ring chromosome 10.2 MDM2 EWSR1 CDK4
45 malignant inflammatory fibrous histiocytoma 10.2 SERPINA3 MDM2 CDK4
46 bladder sarcoma 10.2 SERPINA3 EWSR1
47 bone osteosarcoma 10.2 MDM2 EWSR1 CDK4
48 retroperitoneum carcinoma 10.2 MDM2 CDK4
49 mesenchymal cell neoplasm 10.1 SSX2 SERPINA3 EWSR1
50 autonomic nervous system neoplasm 10.1 SERPINA3 MDM2 EWSR1

Graphical network of the top 20 diseases related to Cellular Myxoid Liposarcoma:



Diseases related to Cellular Myxoid Liposarcoma

Symptoms & Phenotypes for Cellular Myxoid Liposarcoma

GenomeRNAi Phenotypes related to Cellular Myxoid Liposarcoma according to GeneCards Suite gene sharing:

26 (show all 22)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-112 9.75 FUS
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-115 9.75 CDK4
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-116 9.75 CDK4
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-126 9.75 EWSR1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-137 9.75 EWSR1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-140 9.75 EWSR1
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-146 9.75 EWSR1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-21 9.75 CDK4
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-216 9.75 EWSR1
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-23 9.75 SSX1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-3 9.75 FUS
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-42 9.75 CDK4
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-46 9.75 CDK4
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-52 9.75 EWSR1 SSX1
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-53 9.75 CDK4 EWSR1
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-57 9.75 FUS
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-60 9.75 FUS
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-73 9.75 FUS
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-76 9.75 SSX2
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-77 9.75 CDK4 EWSR1 FUS
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-81 9.75 EWSR1 SSX2
22 Decreased shRNA abundance (Z-score < -2) GR00366-A-84 9.75 EWSR1

Drugs & Therapeutics for Cellular Myxoid Liposarcoma

Drugs for Cellular Myxoid Liposarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
2
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2 1177-87-3
3
Trabectedin Approved, Investigational Phase 2 114899-77-3 108150
4 Antiemetics Phase 2
5 Hormones Phase 2
6 Gastrointestinal Agents Phase 2
7 Hormone Antagonists Phase 2
8 glucocorticoids Phase 2
9 Anti-Inflammatory Agents Phase 2
10 Antineoplastic Agents, Hormonal Phase 2
11 Anti-Infective Agents Early Phase 1
12 Interferon-gamma Early Phase 1
13 interferons Early Phase 1
14 Antiviral Agents Early Phase 1
15 Interferon-alpha Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Multicenter Phase II Clinical Trial of Neoadjuvant Trabectedin (Yondelis) in Patients With Localized Myxoid / Round Cell Liposarcoma Completed NCT00579501 Phase 2 Trabectedin;Dexamethasone
2 A Pilot Study of NY-ESO-1ᶜ²⁵⁹T Cells in Subjects With Advanced Myxoid/ Round Cell Liposarcoma Recruiting NCT02992743 Phase 2
3 A Phase 2 Single Arm Open-Label Clinical Trial of ADP-A2M4 SPEAR™ T Cells in Subjects With Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma Recruiting NCT04044768 Phase 2
4 A Phase I Study To Determine the Feasibility of Using Autologous NY-ESO-1 Specific CD8+ T Cells For the Treatment of Patients With Advanced Myxoid/ Round Cell Liposarcoma and Synovial Sarcoma. Completed NCT01477021 Phase 1 cyclophosphamide
5 A Study to Determine the Feasibility of Treating Synovial Sarcoma and Myxoid/Round Cell Liposarcoma Using Autologous NY-ESO-1 Specific CD8+ T Cells With Cyclophosphamide Pre-conditioning But Without the Use of IL-2 Withdrawn NCT02059850 Phase 1 Cyclophosphamide
6 A Pilot Study to Test Whether Systemic Interferon Gamma Increases Tumor Class I MHC Expression in Patients With Synovial Sarcoma and Myxoid/Round Cell Liposarcoma Terminated NCT01957709 Early Phase 1

Search NIH Clinical Center for Cellular Myxoid Liposarcoma

Genetic Tests for Cellular Myxoid Liposarcoma

Anatomical Context for Cellular Myxoid Liposarcoma

MalaCards organs/tissues related to Cellular Myxoid Liposarcoma:

40
T Cells, Kidney, Bone, Heart, Testis, Lymph Node, Skin

Publications for Cellular Myxoid Liposarcoma

Articles related to Cellular Myxoid Liposarcoma:

(show top 50) (show all 176)
# Title Authors PMID Year
1
Soft tissue sarcoma in adolescent and young adult patients: a retrospective study using a nationwide bone and soft tissue tumor registry in Japan. 61
33791777 2021
2
The Utility of Perilipin in Liposarcomas: PLIN1 Differentiates Round Cell Liposarcoma From Other Round Cell Sarcomas. 61
32205741 2021
3
Early radical cystectomy with negative margins in a 57-year-old female with myxoid/round cell liposarcoma of the bladder suggests prolonged overall survival. 61
33776408 2021
4
Myxoid Liposarcoma With Skeletal Metastases: Pathophysiology and Imaging Characteristics. 61
31813645 2021
5
Optimal treatment strategy for paratesticular liposarcoma: retrospective analysis of 265 reported cases. 61
32715355 2020
6
Clinical outcomes of patients with advanced synovial sarcoma or myxoid/round cell liposarcoma treated at major cancer centers in the United States. 61
32374488 2020
7
Hyperprogression of Liver Metastasis With Neoadjuvant Immunotherapy for Soft Tissue Sarcoma. 61
32670711 2020
8
Early detection of multiple bone and extra-skeletal metastases by body magnetic resonance imaging (BMRI) after treatment of Myxoid/Round-Cell Liposarcoma (MRCLS). 61
31447287 2019
9
Systemic Interferon-γ Increases MHC Class I Expression and T-cell Infiltration in Cold Tumors: Results of a Phase 0 Clinical Trial. 61
31171504 2019
10
CBX3 predicts an unfavorable prognosis and promotes tumorigenesis in osteosarcoma. 61
30942427 2019
11
Dedifferentiated Liposarcoma of the Left Thigh: a Rare Case. 61
31391701 2019
12
Retrospective Analysis of Patients with Advanced Liposarcoma in a Tertiary Referral Center. 61
31170709 2019
13
Sarcoma Stem Cell Heterogeneity. 61
31016597 2019
14
EWSR1-NFATC2 and FUS-NFATC2 Gene Fusion-Associated Mesenchymal Tumors: Clinicopathologic Correlation and Literature Review. 61
31049020 2019
15
A Neglected Case of Multifocal Liposarcoma Presented in Five Different Sites in a Syrian Woman: A case report. 61
31743843 2019
16
A Comparison of the Histopathologic Growth Patterns Between Non-Merkel Cell Small Round Blue Cell Tumors and Merkel Cell Carcinoma. 61
30045067 2018
17
Next frontiers in systemic therapy for soft tissue sarcoma. 61
30173533 2018
18
Magnetic Resonance Imaging-guided Brachytherapy Re-irradiation for Isolated Local Recurrence of Soft Tissue Sarcoma. 61
29888161 2018
19
Synovial Sarcoma Is Not Associated With a Higher Risk of Lymph Node Metastasis Compared With Other Soft Tissue Sarcomas. 61
29529647 2018
20
The potential of the CMB305 vaccine regimen to target NY-ESO-1 and improve outcomes for synovial sarcoma and myxoid/round cell liposarcoma patients. 61
29280411 2018
21
FUS-CHOP Promotes Invasion in Myxoid Liposarcoma through a SRC/FAK/RHO/ROCK-Dependent Pathway. 61
29190494 2018
22
Myxoid-round cell liposarcoma: MRI appearance after radiation therapy and relationship to response. 61
29484077 2017
23
[Detection of fusion gene transcript in formalin-fixed paraffin-embedded myxoid/round cell liposarcoma tissues by improved reverse transcription polymerase chain reaction]. 61
29050077 2017
24
Soft tissue sarcomas: From a morphological to a molecular biological approach. 61
28759137 2017
25
T-cell infiltration and clonality correlate with programmed cell death protein 1 and programmed death-ligand 1 expression in patients with soft tissue sarcomas. 61
28463396 2017
26
Efficacy of Trabectedin in Patients with Advanced Translocation-Related Sarcomas: Pooled Analysis of Two Phase II Studies. 61
28526720 2017
27
Establishing a patient-derived xenograft model of human myxoid and round-cell liposarcoma. 61
28903344 2017
28
Trabectedin and Campthotecin Synergistically Eliminate Cancer Stem Cells in Cell-of-Origin Sarcoma Models. 61
28494349 2017
29
Hypercellular round cell liposarcoma: A comprehensive cytomorphologic study and review of 8 cases. 61
28469314 2017
30
Case Report: An incidental finding of an metastases noted in a "cancer to cancer adrenal tumor " from a large malignant nerve sheath tumor of the thigh. 61
29862013 2017
31
The role of histology, grading, location of tumour and ploidy in evaluation of outcome in patients with liposarcoma. 61
29517205 2017
32
Intramuscular Hibernoma of the Scapular Region Misdiagnosed on Cytology as a Malignant Lesion: A Report of a Rare Case. 61
29563939 2017
33
Liposarcoma: Multimodality Management and Future Targeted Therapies. 61
27591497 2016
34
Significant partial response of metastatic intra-abdominal and pelvic round cell liposarcoma to a small-molecule VEGFR-2 tyrosine kinase inhibitor apatinib: A case report. 61
27495042 2016
35
Clinical effect of molecular methods in sarcoma diagnosis (GENSARC): a prospective, multicentre, observational study. 61
26970672 2016
36
Managing Liposarcomas: Cutting Through the Fat. 61
26962163 2016
37
Cement leakage and complication of liposarcoma spinal metastasis during vertebral augmentation procedure: a case report. 61
26911878 2016
38
HSP90 inhibition blocks ERBB3 and RET phosphorylation in myxoid/round cell liposarcoma and causes massive cell death in vitro and in vivo. 61
26595521 2016
39
Prognostic Model to Predict Survival Outcome for Curatively Resected Liposarcoma: A Multi-Institutional Experience. 61
27326262 2016
40
SRC inhibition represents a potential therapeutic strategy in liposarcoma. 61
26084847 2015
41
Retroperitoneal Liposarcoma: an Autopsy Case. 61
28275407 2015
42
Liposarcomas of the posterior mediastinum: clinicopathologic study of 18 cases. 61
25475695 2015
43
Prognostic factors for the recurrence of myxoid liposarcoma: 20 cases with up to 8 years follow-up. 61
25583234 2015
44
Application of molecular biology to individualize therapy for patients with liposarcoma. 61
25993159 2015
45
[Myxoid/round cell liposarcoma of the brachial plexus]. 61
25126709 2014
46
Mode of action of trabectedin in myxoid liposarcomas. 61
24213580 2014
47
Expression of cancer-testis antigens MAGEA1, MAGEA3, ACRBP, PRAME, SSX2, and CTAG2 in myxoid and round cell liposarcoma. 61
24457462 2014
48
Emerging therapies for adult soft tissue sarcoma. 61
24555529 2014
49
Phase I trial of neoadjuvant conformal radiotherapy plus sorafenib for patients with locally advanced soft tissue sarcoma of the extremity. 61
24554062 2014
50
Equivalent cross-relaxation rate imaging positively correlates with pathological grade and cell density of adipocytic tumors. 61
24439360 2014

Variations for Cellular Myxoid Liposarcoma

Expression for Cellular Myxoid Liposarcoma

Search GEO for disease gene expression data for Cellular Myxoid Liposarcoma.

Pathways for Cellular Myxoid Liposarcoma

Pathways related to Cellular Myxoid Liposarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.45 SSX2 SSX1 SS18 MDM2 FUS EWSR1

GO Terms for Cellular Myxoid Liposarcoma

Biological processes related to Cellular Myxoid Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription by RNA polymerase II GO:0045944 9.43 YEATS4 SS18 MDM2 DDIT3 CTAG1B CTAG1A
2 negative regulation of cell cycle arrest GO:0071157 9.16 MDM2 CDK4
3 tRNA threonylcarbamoyladenosine metabolic process GO:0070525 8.62 CTAG1B CTAG1A

Molecular functions related to Cellular Myxoid Liposarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 polysaccharide binding GO:0030247 8.62 CLEC18C CLEC18A

Sources for Cellular Myxoid Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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