MCID: CLL004
MIFTS: 21

Cellular Myxoid Liposarcoma

Categories: Cancer diseases

Aliases & Classifications for Cellular Myxoid Liposarcoma

MalaCards integrated aliases for Cellular Myxoid Liposarcoma:

Name: Cellular Myxoid Liposarcoma 12
Round Cell Liposarcoma 12 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5692
NCIt 50 C4252
SNOMED-CT 68 404070007 43296007
UMLS 73 C0334471

Summaries for Cellular Myxoid Liposarcoma

MalaCards based summary : Cellular Myxoid Liposarcoma, also known as round cell liposarcoma, is related to myxoid liposarcoma and mixed liposarcoma. The drugs Dexamethasone and Rosiglitazone have been mentioned in the context of this disorder. Affiliated tissues include t cells and heart.

Related Diseases for Cellular Myxoid Liposarcoma

Diseases related to Cellular Myxoid Liposarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 12)
# Related Disease Score Top Affiliating Genes
1 myxoid liposarcoma 12.1
2 mixed liposarcoma 11.2
3 liposarcoma 10.6
4 sarcoma, synovial 9.8
5 sarcoma 9.8
6 fibrosarcoma 9.8
7 pemphigus 9.8
8 lichen planus 9.8
9 lichen planus pemphigoides 9.8
10 paraneoplastic pemphigus 9.8
11 myxofibrosarcoma 9.8
12 well-differentiated liposarcoma 9.8

Graphical network of the top 20 diseases related to Cellular Myxoid Liposarcoma:



Diseases related to Cellular Myxoid Liposarcoma

Symptoms & Phenotypes for Cellular Myxoid Liposarcoma

Drugs & Therapeutics for Cellular Myxoid Liposarcoma

Drugs for Cellular Myxoid Liposarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone Approved, Investigational, Vet_approved Phase 2 50-02-2 5743
2
Rosiglitazone Approved, Investigational Phase 2 122320-73-4 77999
3
Trabectedin Approved, Investigational Phase 2 114899-77-3 108150
4
Maleic acid Experimental Phase 2 110-16-7 444266
5 Dexamethasone acetate Phase 2 1177-87-3
6 Alkylating Agents Phase 2,Phase 1
7 glucocorticoids Phase 2
8
protease inhibitors Phase 2
9 Gastrointestinal Agents Phase 2
10 HIV Protease Inhibitors Phase 2
11 Hormone Antagonists Phase 2
12 Hormones Phase 2
13 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2
14 Peripheral Nervous System Agents Phase 2
15 Hypoglycemic Agents Phase 2
16 Antiemetics Phase 2
17 Anti-Inflammatory Agents Phase 2
18 BB 1101 Phase 2
19 Autonomic Agents Phase 2
20 Antineoplastic Agents, Alkylating Phase 2,Phase 1
21 Antineoplastic Agents, Hormonal Phase 2
22 Antibodies Phase 2,Phase 1
23 Immunoglobulins Phase 2,Phase 1
24 Antibodies, Monoclonal Phase 2,Phase 1
25
Cyclophosphamide Approved, Investigational Phase 1 50-18-0, 6055-19-2 2907
26
Fludarabine Approved Phase 1 21679-14-1, 75607-67-9 30751
27 Immunosuppressive Agents Phase 1
28 Antirheumatic Agents Phase 1
29 interferons Not Applicable
30 Anti-Infective Agents Not Applicable
31 Interferon-alpha Not Applicable
32 Interferon-gamma Not Applicable
33 Antiviral Agents Not Applicable

Interventional clinical trials:

(show all 14)
# Name Status NCT ID Phase Drugs
1 Activity and Tolerability of Pazopanib in Advanced and/or Metastatic Liposarcoma. A Phase II Clinical Trial Unknown status NCT01692496 Phase 2 Pazopanib
2 Safety and Efficacy Study of Trabectedin for the Treatment of Localized Myxoid / Round Cell Liposarcoma Completed NCT00579501 Phase 2 Trabectedin;Dexamethasone
3 Rosiglitazone in Treating Patients With Liposarcoma Completed NCT00004180 Phase 2 rosiglitazone maleate
4 A Pilot Study of NY-ESO-1ᶜ²⁵⁹T Cells in Subjects With Advanced Myxoid/ Round Cell Liposarcoma Recruiting NCT02992743 Phase 1, Phase 2
5 Trial of CMB305 and Atezolizumab in Patients With Sarcoma Active, not recruiting NCT02609984 Phase 2
6 Immune Changes Following Trabectedin in Patients With Metastatic or Unresectable Sarcoma Not yet recruiting NCT03397186 Phase 2 Trabectedin
7 Efficacy and Safety of Plitidepsin in Patients With Advanced Unresectable or Metastatic, Relapsed/Refractory, Dedifferentiated Liposarcoma (DLPS): an Exploratory Phase II Multicenter Trial Terminated NCT01876043 Phase 2 plitidepsin
8 Autologous T Cells and Cyclophosphamide in Treating Patients With Soft Tissue Sarcoma That is Metastatic or Cannot Be Removed By Surgery Completed NCT01477021 Phase 1 cyclophosphamide
9 NY-ESO-1-redirected CRISPR (TCRendo and PD1) Edited T Cells (NYCE T Cells) Recruiting NCT03399448 Phase 1 Cyclophosphamide;Fludarabine
10 MAGE-A4ᶜ¹º³²T for Multi-Tumor Recruiting NCT03132922 Phase 1
11 Study of Adoptive Immunotherapy Using Autologous CD8+ NY-ESO-1-Specific T Cells and the NY-ESO-1 Immunostimulatory Agents LV305 or CMB305 For Patients With Sarcoma Not yet recruiting NCT03450122 Phase 1 Cyclophosphamide
12 NY-ESO-1 Specific T Cells After Cyclophosphamide in Treating Patients With Advanced Synovial Sarcoma or Myxoid/Round Cell Liposarcoma Withdrawn NCT02059850 Phase 1 Cyclophosphamide
13 Adoptive Therapy Using Antigen-Specific CD4 T-Cells Withdrawn NCT02210104 Phase 1 Ipilimumab;Cyclophosphamide
14 Recombinant Interferon Gamma in Treating Patients With Soft Tissue Sarcoma Recruiting NCT01957709 Not Applicable

Search NIH Clinical Center for Cellular Myxoid Liposarcoma

Genetic Tests for Cellular Myxoid Liposarcoma

Anatomical Context for Cellular Myxoid Liposarcoma

MalaCards organs/tissues related to Cellular Myxoid Liposarcoma:

41
T Cells, Heart

Publications for Cellular Myxoid Liposarcoma

Articles related to Cellular Myxoid Liposarcoma:

(show all 38)
# Title Authors Year
1
The potential of the CMB305 vaccine regimen to target NY-ESO-1 and improve outcomes for synovial sarcoma and myxoid/round cell liposarcoma patients. ( 29280411 )
2018
2
Establishing a patient-derived xenograft model of human myxoid and round-cell liposarcoma. ( 28903344 )
2017
3
HSP90 inhibition blocks ERBB3 and RET phosphorylation in myxoid/round cell liposarcoma and causes massive cell death in vitro and in vivo. ( 26595521 )
2016
4
Significant partial response of metastatic intra-abdominal and pelvic round cell liposarcoma to a small-molecule VEGFR-2 tyrosine kinase inhibitor apatinib: A case report. ( 27495042 )
2016
5
Normal and Functional TP53 in Genetically Stable Myxoid/Round Cell Liposarcoma. ( 25393000 )
2014
6
Cell senescence in myxoid/round cell liposarcoma. ( 25093008 )
2014
7
Paratesticular myxoid/round cell liposarcoma harboring type 3 DDIT3-FUS fusion gene: report of a very rare case. ( 23276404 )
2013
8
Localized and metastatic myxoid/round cell liposarcoma: clinical and molecular observations. ( 23401071 )
2013
9
NY-ESO-1 is a sensitive and specific immunohistochemical marker for myxoid and round cell liposarcomas among related mesenchymal myxoid neoplasms. ( 23599152 )
2013
10
Round cell liposarcoma metastatic to the heart. ( 23808478 )
2013
11
PPARI^ agonists enhance ET-743-induced adipogenic differentiation in a transgenic mouse model of myxoid round cell liposarcoma. ( 22293175 )
2012
12
Metastatic patterns of myxoid/round cell liposarcoma: a review of a 25-year experience. ( 22550416 )
2012
13
Myxoid/round cell liposarcoma of the supraclavicular fossa. ( 22359136 )
2012
14
Involvement of the PI3K/Akt pathway in myxoid/round cell liposarcoma. ( 22020193 )
2012
15
NY-ESO-1 is a ubiquitous immunotherapeutic target antigen for patients with myxoid/round cell liposarcoma. ( 22359263 )
2012
16
Round cell liposarcoma arising in the left foot: MRI and PET findings. ( 22965582 )
2012
17
Prognostic factors and metastatic patterns in primary myxoid/round-cell liposarcoma. ( 22190864 )
2011
18
Round cell liposarcoma presenting as an FDG-positive primary with an FDG-negative retroperitoneal metastasis: a pitfall for F-18 FDG PET/CT imaging. ( 22064114 )
2011
19
Subcutaneous myxoid and round cell liposarcoma. ( 21909204 )
2011
20
[Identification of genes over-expressed in myxoid/round cell liposarcoma. DNA microarray analysis and immunohistochemical correlation]. ( 19823827 )
2010
21
Primary retroperitoneal myxoid/round cell liposarcoma is a nonexisting disease: an immunohistochemical and molecular biological analysis. ( 18820664 )
2009
22
Irradiation of myxoid/round cell liposarcoma induces volume reduction and lipoma-like morphology. ( 17653909 )
2007
23
The myxoid/round cell liposarcoma fusion oncogene FUS-DDIT3 and the normal DDIT3 induce a liposarcoma phenotype in transfected human fibrosarcoma cells. ( 16651630 )
2006
24
Hypermethylation of the APC promoter but lack of APC mutations in myxoid/round-cell liposarcoma. ( 16858687 )
2006
25
Re: Oda et al. Frequent alteration of p16INK4a/p14ARF and p53 pathways in the round cell component of myxoid/round cell liposarcoma: p53 gene alterations and reduced p14ARF expression both correlate with poor prognosis. J Pathol 2005;207:410-421. ( 16622896 )
2006
26
Frequent alteration of p16(INK4a)/p14(ARF) and p53 pathways in the round cell component of myxoid/round cell liposarcoma: p53 gene alterations and reduced p14(ARF) expression both correlate with poor prognosis. ( 16177957 )
2005
27
[Detection of FUS-CHOP fusion gene in paraffin-embedded tissues and its clinicopathologic significance for myxoid/round cell liposarcomas]. ( 15796878 )
2005
28
Round cell liposarcoma of scrotum with indolent course in young adult. ( 16536120 )
2005
29
Inconspicuous insertion 22;12 in myxoid/round cell liposarcoma accompanied by the secondary structural abnormality der(16)t(1;16). ( 12876210 )
2003
30
Mixed myxoid/round cell liposarcoma of the scalp. ( 12649828 )
2003
31
The association between tumour progression and vascularity in myxofibrosarcoma and myxoid/round cell liposarcoma. ( 11213831 )
2001
32
Specificity of TLS-CHOP rearrangement for classic myxoid/round cell liposarcoma: absence in predominantly myxoid well-differentiated liposarcomas. ( 11229517 )
2000
33
High telomerase activity and high HTRT mRNA expression differentiate pure myxoid and myxoid/round-cell liposarcomas. ( 10719732 )
2000
34
Molecular aberrations of the G1-S checkpoint in myxoid and round cell liposarcoma. ( 9403703 )
1997
35
Retroperitoneal round-cell liposarcoma associated with paraneoplastic pemphigus presenting as lichen planus pemphigoides-like eruption. ( 9268753 )
1997
36
Myxoid/round cell liposarcoma of the extremities. A clinicopathologic study of 29 cases with particular attention to extent of round cell liposarcoma. ( 8554106 )
1996
37
Chimeric TLS/FUS-CHOP gene expression and the heterogeneity of its junction in human myxoid and round cell liposarcoma. ( 7485386 )
1995
38
Translocation t(12;16)(q13;p11) in myxoid liposarcoma and round cell liposarcoma: molecular and cytogenetic analysis. ( 7805034 )
1995

Variations for Cellular Myxoid Liposarcoma

Expression for Cellular Myxoid Liposarcoma

Search GEO for disease gene expression data for Cellular Myxoid Liposarcoma.

Pathways for Cellular Myxoid Liposarcoma

GO Terms for Cellular Myxoid Liposarcoma

Sources for Cellular Myxoid Liposarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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