MCID: CLL006
MIFTS: 23

Cellular Neurofibroma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Cellular Neurofibroma

MalaCards integrated aliases for Cellular Neurofibroma:

Name: Cellular Neurofibroma 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:5152
NCIt 50 C41427
UMLS 73 C1516371

Summaries for Cellular Neurofibroma

MalaCards based summary : Cellular Neurofibroma is related to leukocyte disease and chronic eosinophilic leukemia. An important gene associated with Cellular Neurofibroma is PDGFRB (Platelet Derived Growth Factor Receptor Beta), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Related phenotypes are Decreased viability and Decreased viability

Related Diseases for Cellular Neurofibroma

Diseases related to Cellular Neurofibroma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 42)
# Related Disease Score Top Affiliating Genes
1 leukocyte disease 10.1 CD34 PDGFRB
2 chronic eosinophilic leukemia 10.0 ABL1 PDGFRB
3 neurofibroma 10.0
4 myeloproliferative neoplasm 9.9 ABL1 PDGFRB
5 meninges sarcoma 9.8 CD34 TP53
6 sarcomatoid squamous cell skin carcinoma 9.8 CD34 TP53
7 sclerosing liposarcoma 9.8 CD34 TP53
8 periosteal osteogenic sarcoma 9.8 CD34 TP53
9 breast benign neoplasm 9.8 CD34 TP53
10 thoracic benign neoplasm 9.8 CD34 TP53
11 liver angiosarcoma 9.8 CD34 TP53
12 clear cell ependymoma 9.8 CD34 TP53
13 cellular schwannoma 9.8 CD34 TP53
14 muscle cancer 9.8 CD34 TP53
15 hypereosinophilic syndrome 9.8 ABL1 PDGFRB
16 connective tissue cancer 9.8 CD34 TP53
17 organ system benign neoplasm 9.8 CD34 TP53
18 peripheral nervous system neoplasm 9.7 CD34 TP53
19 cell type benign neoplasm 9.7 CD34 TP53
20 precursor t-cell acute lymphoblastic leukemia 9.7 ABL1 CD34
21 sarcoma 9.7
22 nervous system cancer 9.7 CD34 TP53
23 leiomyosarcoma 9.6 PDGFRB TP53
24 liposarcoma 9.6 CD34 TP53
25 cell type cancer 9.6 CD34 TP53
26 polycythemia vera 9.6 ABL1 PDGFRB
27 endometrial stromal sarcoma 9.6 PDGFRB TP53
28 leukemia, acute lymphoblastic 3 9.6 ABL1 TP53
29 childhood leukemia 9.6 ABL1 TP53
30 gastrointestinal system cancer 9.6 CD34 TP53
31 bone marrow cancer 9.5 ABL1 CD34 PDGFRB
32 leukemia, chronic myeloid 9.4 ABL1 CD34 PDGFRB
33 pilocytic astrocytoma 9.4 PDGFRB TP53
34 aging 9.2 PDGFRB TP53
35 dermatofibrosarcoma protuberans 9.2 CD34 PDGFRB TP53
36 meningioma, familial 9.2 CD34 PDGFRB TP53
37 ewing sarcoma 9.1 CD34 PDGFRB TP53
38 leukemia, acute myeloid 9.1 ABL1 CD34 TP53
39 essential thrombocythemia 8.9 ABL1 TP53
40 gastrointestinal stromal tumor 8.5 ABL1 CD34 PDGFRB TP53
41 hematologic cancer 8.5 ABL1 CD34 PDGFRB TP53
42 myelodysplastic syndrome 8.5 ABL1 CD34 PDGFRB TP53

Graphical network of the top 20 diseases related to Cellular Neurofibroma:



Diseases related to Cellular Neurofibroma

Symptoms & Phenotypes for Cellular Neurofibroma

GenomeRNAi Phenotypes related to Cellular Neurofibroma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 9.4 ABL1 PDGFRB
2 Decreased viability GR00221-A-2 9.4 ABL1
3 Decreased viability GR00221-A-3 9.4 ABL1 PDGFRB
4 Decreased viability GR00221-A-4 9.4 PDGFRB
5 Decreased viability GR00342-S-1 9.4 ABL1 PDGFRB
6 Decreased viability GR00342-S-2 9.4 ABL1
7 Decreased viability GR00342-S-3 9.4 ABL1
8 Decreased viability GR00402-S-2 9.4 ABL1 PDGFRB

Drugs & Therapeutics for Cellular Neurofibroma

Search Clinical Trials , NIH Clinical Center for Cellular Neurofibroma

Genetic Tests for Cellular Neurofibroma

Anatomical Context for Cellular Neurofibroma

Publications for Cellular Neurofibroma

Articles related to Cellular Neurofibroma:

# Title Authors Year
1
Cellular neurofibroma with atypia mimics sarcoma: report of a case with immunohistochemical staining pattern analysis and literature review. ( 17098683 )
2006
2
A case of episcleral cellular neurofibroma. ( 17318327 )
2005
3
Neurofibroma and cellular neurofibroma with atypia: a report of 14 tumors. ( 10478679 )
1999
4
Neurofibroma and cellular neurofibroma with atypia: a report of 14 tumors. ( 9414187 )
1997

Variations for Cellular Neurofibroma

Expression for Cellular Neurofibroma

Search GEO for disease gene expression data for Cellular Neurofibroma.

Pathways for Cellular Neurofibroma

Pathways related to Cellular Neurofibroma according to GeneCards Suite gene sharing:

(show all 18)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.4 ABL1 PDGFRB TP53
2 12.3 ABL1 PDGFRB TP53
3 11.81 ABL1 PDGFRB TP53
4 11.77 ABL1 TP53
5 11.75 ABL1 TP53
6 11.73 ABL1 PDGFRB
7 11.61 ABL1 TP53
8 11.58 PDGFRB TP53
9 11.45 ABL1 TP53
10
Show member pathways
11.43 ABL1 TP53
11 11.27 PDGFRB TP53
12
Show member pathways
11.23 ABL1 PDGFRB
13 11.14 ABL1 TP53
14 11.05 ABL1 PDGFRB
15 10.96 ABL1 TP53
16 10.94 ABL1 TP53
17 10.3 ABL1 TP53
18
Show member pathways
9.97 ABL1 TP53

GO Terms for Cellular Neurofibroma

Biological processes related to Cellular Neurofibroma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell cycle arrest GO:0007050 9.43 ABL1 TP53
2 positive regulation of apoptotic process GO:0043065 9.43 ABL1 PDGFRB TP53
3 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.4 ABL1 PDGFRB
4 positive regulation of peptidyl-tyrosine phosphorylation GO:0050731 9.37 ABL1 TP53
5 regulation of actin cytoskeleton organization GO:0032956 9.32 ABL1 PDGFRB
6 platelet-derived growth factor receptor signaling pathway GO:0048008 9.16 ABL1 PDGFRB
7 positive regulation of reactive oxygen species metabolic process GO:2000379 8.96 PDGFRB TP53
8 platelet-derived growth factor receptor-beta signaling pathway GO:0035791 8.62 ABL1 PDGFRB

Sources for Cellular Neurofibroma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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