MCID: CLL001
MIFTS: 29

Cellular Schwannoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Cellular Schwannoma

MalaCards integrated aliases for Cellular Schwannoma:

Name: Cellular Schwannoma 12 6 15 70
Cellular Neurinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3196
NCIt 50 C4724
SNOMED-CT 67 253086004
UMLS 70 C0431124

Summaries for Cellular Schwannoma

Disease Ontology : 12 A neurilemmoma with a predominantly cellular growth but no Verocay bodies.

MalaCards based summary : Cellular Schwannoma, also known as cellular neurinoma, is related to perineurioma and monosomy 22. An important gene associated with Cellular Schwannoma is SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1), and among its related pathways/superpathways is Chromatin Regulation / Acetylation. Affiliated tissues include kidney, spinal cord and lung, and related phenotypes are Increased proliferation and embryo

Related Diseases for Cellular Schwannoma

Diseases related to Cellular Schwannoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 150)
# Related Disease Score Top Affiliating Genes
1 perineurioma 30.1 S100A1 NF1
2 monosomy 22 30.0 SMARCB1 NF2
3 plexiform neurofibroma 30.0 NF2 NF1
4 neurilemmoma 29.9 SOX10 SMARCB1 S100A1 NF2 NF1 CD34
5 exophthalmos 29.7 NF1 CD34
6 smooth muscle tumor 29.6 S100A1 CD34
7 neurilemmomatosis 29.4 SOX10 SMARCB1 NF2 NF1
8 sarcoma 29.2 SSX1 SS18 SMARCB1 NF2
9 neurofibroma 29.1 SOX10 S100A1 NF2 NF1 CD34
10 hemangiopericytoma, malignant 29.1 SSX1 SS18 CD34
11 spindle cell sarcoma 29.1 SSX1 SS18 NF2 CD34
12 malignant peripheral nerve sheath tumor 29.0 SOX10 SMARCB1 S100A1 NF2 NF1 CD34
13 plexiform schwannoma 28.9 SOX10 SMARCB1 NF2 NF1 CD34
14 neurilemmoma of the fifth cranial nerve 10.3 NF2 NF1
15 trigeminal nerve neoplasm 10.3 NF2 NF1
16 cerebral falx meningioma 10.3 NF2 NF1
17 polyp of corpus uteri 10.3 NF2 NF1
18 rete ovarii adenoma 10.2 NF2 NF1
19 rete ovarii benign neoplasm 10.2 NF2 NF1
20 optic nerve glioma 10.2 NF2 NF1
21 chordoid meningioma 10.2 S100A1 NF2
22 obstructive hydrocephalus 10.2 NF2 NF1
23 benign ependymoma 10.2 NF2 NF1
24 optic nerve astrocytoma 10.2 SMARCB1 NF1
25 melanotic neurilemmoma 10.2 SMARCB1 NF2
26 meningioma, radiation-induced 10.2 SMARCB1 NF2
27 rhabdoid meningioma 10.2 SMARCB1 NF2
28 schwannomatosis 1 10.2 SMARCB1 NF2
29 secretory meningioma 10.2 SMARCB1 NF2
30 sturge-weber syndrome 10.2 NF2 NF1
31 chondroma 10.2 S100A1 NF1
32 acoustic neuroma 10.2 NF2 NF1
33 chondroid chordoma 10.1 SMARCB1 S100A1
34 cerebral ventricle cancer 10.1 SMARCB1 NF2
35 cerebrum cancer 10.1 SMARCB1 NF2
36 supratentorial cancer 10.1 SMARCB1 NF2
37 parasagittal meningioma 10.1 NF2 CD34
38 lung meningioma 10.1 NF2 CD34
39 psammomatous meningioma 10.1 NF2 CD34
40 meninges hemangiopericytoma 10.1 NF2 CD34
41 mechanical ectropion 10.1 NF1 CD34
42 epidural spinal canal neoplasm 10.1 NF2 CD34
43 angiomatous meningioma 10.1 NF2 CD34
44 pacinian tumor 10.1 NF1 CD34
45 neurofibromatosis 10.1
46 subungual glomus tumor 10.1 NF1 CD34
47 fibrous meningioma 10.1 NF2 CD34
48 kidney fibrosarcoma 10.1 SSX1 SMARCB1
49 spinal cord disease 10.1 NF2 NF1
50 glomus tumor 10.1 S100A1 CD34

Graphical network of the top 20 diseases related to Cellular Schwannoma:



Diseases related to Cellular Schwannoma

Symptoms & Phenotypes for Cellular Schwannoma

GenomeRNAi Phenotypes related to Cellular Schwannoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 NF2 SMARCB1

MGI Mouse Phenotypes related to Cellular Schwannoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 embryo MP:0005380 9.43 CHD4 NF1 NF2 SMARCB1 SOX10 SS18
2 neoplasm MP:0002006 9.02 CD34 NF1 NF2 SMARCB1 SOX10

Drugs & Therapeutics for Cellular Schwannoma

Search Clinical Trials , NIH Clinical Center for Cellular Schwannoma

Genetic Tests for Cellular Schwannoma

Anatomical Context for Cellular Schwannoma

MalaCards organs/tissues related to Cellular Schwannoma:

40
Kidney, Spinal Cord, Lung, Adrenal Gland, Trigeminal Ganglion, Tongue, Pituitary

Publications for Cellular Schwannoma

Articles related to Cellular Schwannoma:

(show top 50) (show all 120)
# Title Authors PMID Year
1
Paraspinal plexiform schwannoma of unknown nerve origin: A case report. 61
33486308 2021
2
Tongue Schwannoma: A Clinicopathologic Study of 19 Cases. 61
31485983 2020
3
Intracranial cellular schwannomas: a clinicopathological study of 20 cases. 61
31379028 2020
4
Successful Excision of Endobronchial Cellular Schwannoma With Right Lower Sleeve Lobectomy. 61
30205116 2019
5
MR imaging of vaginal cellular schwannoma. 61
30195699 2019
6
CHD4 as a Potential Biomarker in Differentiating Between Cellular Schwannoma and Malignant Peripheral Nerve Sheath Tumor. 61
28549031 2018
7
Expression of PAX3 Distinguishes Biphenotypic Sinonasal Sarcoma From Histologic Mimics. 61
29863547 2018
8
Spinal cellular schwannoma: An analysis of imaging manifestation and clinicopathological findings. 61
30017303 2018
9
Large retroperitoneal schwannoma: a rare cause of chronic back pain. 61
29896991 2018
10
Unusual presentation of retroperitoneal Schwannoma: case report. 61
29442061 2017
11
TFG-MET fusion in an infantile spindle cell sarcoma with neural features. 61
28510278 2017
12
Selected benign cutaneous lesions that may simulate melanoma histologically. 61
27221234 2016
13
Methylation-based classification of benign and malignant peripheral nerve sheath tumors. 61
26857854 2016
14
Cutaneous Cellular Pseudoglandular Schwannoma: An Unusual Histopathologic Variant. 61
26844614 2016
15
Loss of H3K27 trimethylation distinguishes malignant peripheral nerve sheath tumors from histologic mimics. 61
26585554 2016
16
Spontaneous acute hemorrhage of intraspinal canal cellular schwannoma with paraplegia: A case report. 61
25488387 2015
17
Cellular schwannoma of the retroperitoneum with cystic degeneration, mimicking an ovarian cyst, with CKAE1/AE3 and desmin expression. 61
25180931 2015
18
Morphologic and immunohistochemical features of malignant peripheral nerve sheath tumors and cellular schwannomas. 61
25189642 2015
19
[One case of nasal cellular schwannoma]. 61
25598379 2014
20
A recurrent cellular schwannoma. 61
25346907 2014
21
Atypical presentation of sinonasal cellular schwannoma: a nonsolitary mass with osseous, orbital, and intracranial invasion. 61
25083375 2014
22
Primary pleural hybrid cellular schwannoma/perineurioma: a case report. 61
24998375 2014
23
Large Vestibular Schwannomas Presenting during Pregnancy: Management Strategies. 61
25072015 2014
24
Infantile cellular schwannoma developing on the skin with atypical clinical features. 61
25232315 2014
25
An unusual location for cellular schwannoma. 61
24718004 2014
26
Cellular schwannoma arising from the gastric wall misdiagnosed as a gastric stromal tumor: A case report. 61
24396458 2014
27
Conventional spindle cell-type malignant peripheral nerve sheath tumor arising in a sporadic schwannoma. 61
24007690 2013
28
Cellular schwannoma arising from sigmoid mesocolon presenting as torsion. 61
24349845 2013
29
Giant invasive sacral schwannoma showing chromosomal numerical aberrations [-14,+18,+22]. 61
24066220 2013
30
Cellular schwannoma masquerading as malignant peripheral nerve sheath tumour: a diagnostic dilemma. 61
23709140 2013
31
Combined craniofacial approach for the removal of a large trigeminal schwannoma invading the infratemporal fossa. 61
21842149 2012
32
A spinal epidural dumbbell cellular schwannoma in an infant. 61
22325076 2012
33
Clinicopathologic and molecular analysis of a choroidal pigmented schwannoma in the context of a PTEN hamartoma tumor syndrome. 61
22281088 2012
34
Resection of perihilar biliary schwannoma. 61
21665464 2011
35
[A 33 year old woman with a six-year history of slight thoracic-abdominal pain]. 61
21527973 2011
36
Low-back pain as the presenting sign in a patient with a giant, sacral cellular schwannoma: 10-year follow-up. 61
21214314 2011
37
Trisomy 17 in congenital plexiform (multinodular) cellular schwannoma. 61
21156251 2010
38
Intrapulmonary cellular schwannoma. 61
20868846 2010
39
Giant schwannoma of the lumbar spine. A case report. 61
20358489 2010
40
Meningothelial-like whorls in a retroperitoneal cellular schwannoma: potential diagnostic pitfall. 61
20055955 2010
41
Non-healing ulcer on the great toe due to cellular schwannoma. 61
20055863 2009
42
Primary intraventricular schwannomas. 61
19632768 2009
43
Cellular schwannoma of the abducens nerve: case report and review of the literature. 61
19200646 2009
44
Retroperitoneal schwannoma mimicking uterine myoma. 61
19574183 2009
45
A huge cystic cellular schwannoma of the intercostal nerve presenting with dyspnea. 61
19324168 2009
46
Malignant peripheral nerve sheath tumors of cranial nerves and intracranial contents: a clinicopathologic study of 17 cases. 61
19065105 2009
47
Review of a series with abducens nerve palsy. 61
19107682 2008
48
Cellular schwannoma of the greater superficial petrosal nerve presenting with abducens nerve palsy and xerophthalmia: case report. 61
18981849 2008
49
Perirenal schwannoma: a case report. 61
18518995 2008
50
A 61-year-old man with hyponatremia. 61
18363939 2008

Variations for Cellular Schwannoma

ClinVar genetic disease variations for Cellular Schwannoma:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 SMARCB1 NM_003073.5(SMARCB1):c.*82C>T SNV Pathogenic 239481 rs878854600 GRCh37: 22:24176449-24176449
GRCh38: 22:23834262-23834262

Expression for Cellular Schwannoma

Search GEO for disease gene expression data for Cellular Schwannoma.

Pathways for Cellular Schwannoma

Pathways related to Cellular Schwannoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.21 SS18 SMARCB1 CHD4

GO Terms for Cellular Schwannoma

Cellular components related to Cellular Schwannoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.76 SSX1 SS18 SOX10 SMARCB1 S100A1 NF2
2 SWI/SNF complex GO:0016514 8.96 SS18 SMARCB1
3 npBAF complex GO:0071564 8.62 SS18 SMARCB1

Biological processes related to Cellular Schwannoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ATP-dependent chromatin remodeling GO:0043044 9.16 SMARCB1 CHD4
2 negative regulation of MAPK cascade GO:0043409 8.96 NF2 NF1
3 peripheral nervous system development GO:0007422 8.62 SOX10 NF1

Molecular functions related to Cellular Schwannoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription factor binding GO:0008134 9.13 SOX10 CHD4 CD34
2 nucleosomal DNA binding GO:0031492 8.62 SMARCB1 CHD4

Sources for Cellular Schwannoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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