MCID: CLL001
MIFTS: 40

Cellular Schwannoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Cellular Schwannoma

MalaCards integrated aliases for Cellular Schwannoma:

Name: Cellular Schwannoma 12 15 73
Cellular Neurinoma 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3196
NCIt 50 C4724
SNOMED-CT 68 985004
UMLS 73 C0431124

Summaries for Cellular Schwannoma

Disease Ontology : 12 A neurilemmoma with a predominantly cellular growth but no Verocay bodies.

MalaCards based summary : Cellular Schwannoma, also known as cellular neurinoma, is related to neurilemmoma and perineurioma. An important gene associated with Cellular Schwannoma is NF2 (Neurofibromin 2), and among its related pathways/superpathways are Endometrial cancer and Pathways in cancer. Affiliated tissues include skin, bone and brain, and related phenotypes are cellular and behavior/neurological

Related Diseases for Cellular Schwannoma

Diseases related to Cellular Schwannoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 neurilemmoma 30.1 NF1 NF2 NGFR S100B SOX10
2 perineurioma 29.8 DSP S100B SLC2A1
3 neurofibroma 29.3 CD34 CDKN2A NF1 NF2 S100B SOX10
4 malignant peripheral nerve sheath tumor 29.0 CDKN2A MDM2 NF1 NF2 S100A1 S100B
5 neurofibromatosis, familial spinal 10.3 NF1 NF2
6 spinal meningioma 10.2 NF1 NF2 SOX10
7 spinal canal and spinal cord meningioma 10.2 NF1 NF2 SOX10
8 malignant iris melanoma 10.2 S100A1 S100B
9 eosinophilic variant of chromophobe renal cell carcinoma 10.2 S100A1 SLC2A1
10 central nervous system mesenchymal non-meningothelial tumor 10.2 PAX3 PAX7
11 malignant triton tumor 10.2 NF1 S100B
12 malignant spindle cell melanoma 10.2 NF1 NGFR SOX10
13 malignant peritoneal mesothelioma 10.2 CDKN2A NF2
14 gliofibroma 10.2 NF1 TP53
15 epithelioid neurofibroma 10.2 CD34 DSP
16 optic nerve sheath meningioma 10.2 CDKN2A NF2
17 epithelioid malignant peripheral nerve sheath tumor 10.2 NF1 S100B
18 renal pelvis adenocarcinoma 10.2 PAX8 SLC2A1
19 cerebral convexity meningioma 10.2 NF2 TP53
20 conventional leiomyosarcoma 10.2 CDKN2A NF1 PAX7
21 fibrous meningioma 10.1 NF2 S100B
22 psammomatous meningioma 10.1 CD34 NF2
23 mixed type thymoma 10.1 PAX8 S100B
24 atrophy of prostate 10.1 SLC2A1 TP53
25 autosomal genetic disease 10.1 NF1 NF2 TP53
26 vulvar dystrophy 10.1 CD34 CDKN2A
27 nephrogenic adenofibroma 10.1 CD34 NF1 PAX8
28 malignant giant cell tumor 10.1 S100B TP53
29 chordoma 10.1 CDKN2A S100A1 S100B
30 chordoid glioma 10.1 NF2 S100B TP53
31 bladder squamous cell carcinoma 10.1 CDKN2A TP53
32 cellular neurofibroma 10.1 CD34 TP53
33 optic nerve glioma 10.1 NF1 S100B TP53
34 keratinizing squamous cell carcinoma 10.0 CDKN2A TP53
35 juvenile pilocytic astrocytoma 10.0 CDKN2A NF1 TP53
36 differentiated thyroid carcinoma 10.0 PAX8 TFG TP53
37 ring chromosome 7 10.0 MDM2 TP53
38 zika virus infection 10.0 MDM2 TP53
39 cellular myxoid liposarcoma 10.0 MDM2 PAX7
40 anaplastic ependymoma 10.0 MDM2 NF2 S100B
41 infiltrating angiolipoma 10.0 CDKN2A MDM2
42 spindle cell sarcoma 10.0 MDM2 NF2 S100B
43 olfactory groove meningioma 10.0 NF2 TP53
44 rhabdomyosarcoma 2 10.0 MDM2 PAX3 PAX7
45 endocervical adenocarcinoma 10.0 CDKN2A PAX8 TP53
46 meninges sarcoma 10.0 CD34 TP53
47 actinic cheilitis 10.0 MDM2 TP53
48 optic nerve neoplasm 10.0 CDKN2A NF1 NF2 TP53
49 spitz nevus 10.0 CDKN2A TP53
50 fibroepithelial basal cell carcinoma 10.0 CD34 TP53

Graphical network of the top 20 diseases related to Cellular Schwannoma:



Diseases related to Cellular Schwannoma

Symptoms & Phenotypes for Cellular Schwannoma

MGI Mouse Phenotypes related to Cellular Schwannoma:

46 (show all 26)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.55 CD34 CDKN2A CHD4 DSP MAML3 MDM2
2 behavior/neurological MP:0005386 10.53 CDKN2A CHD4 MDM2 NF1 NF2 NGFR
3 growth/size/body region MP:0005378 10.49 CDKN2A CHD4 DSP MAML3 MDM2 NF1
4 embryo MP:0005380 10.47 CDKN2A CHD4 DSP MAML3 MDM2 NF1
5 homeostasis/metabolism MP:0005376 10.4 CD34 CDKN2A MDM2 NF1 NF2 NGFR
6 mortality/aging MP:0010768 10.4 CDKN2A CHD4 DSP MAML3 MDM2 NF1
7 craniofacial MP:0005382 10.35 DSP MAML3 MDM2 NF1 NF2 NGFR
8 endocrine/exocrine gland MP:0005379 10.33 CDKN2A CHD4 MDM2 NF1 NF2 PAX3
9 immune system MP:0005387 10.33 CD34 CDKN2A CHD4 MDM2 NF1 NF2
10 cardiovascular system MP:0005385 10.32 CDKN2A DSP MAML3 MDM2 NF1 NGFR
11 integument MP:0010771 10.31 CD34 CDKN2A DSP MDM2 NF1 NF2
12 nervous system MP:0003631 10.31 CDKN2A DSP MAML3 MDM2 NF1 NF2
13 digestive/alimentary MP:0005381 10.3 CDKN2A DSP MDM2 NF1 NGFR PAX3
14 hematopoietic system MP:0005397 10.27 CD34 CDKN2A CHD4 MDM2 NF1 NGFR
15 neoplasm MP:0002006 10.2 CD34 CDKN2A MDM2 NF1 NF2 PAX3
16 muscle MP:0005369 10.18 CDKN2A DSP MDM2 NF1 NGFR PAX3
17 normal MP:0002873 10.15 MAML3 MDM2 NF1 NGFR PAX3 PAX7
18 hearing/vestibular/ear MP:0005377 10.12 NF1 NF2 NGFR PAX3 PAX8 SOX2
19 no phenotypic analysis MP:0003012 10.1 CDKN2A CHD4 MDM2 PAX3 PAX7 PAX8
20 limbs/digits/tail MP:0005371 10.07 MDM2 NF1 NGFR PAX3 PAX8 SOX10
21 liver/biliary system MP:0005370 10.05 CDKN2A MDM2 NF1 NF2 NGFR PAX3
22 pigmentation MP:0001186 9.92 CDKN2A MDM2 NF1 PAX3 SOX10 SOX2
23 respiratory system MP:0005388 9.85 CDKN2A NF1 NF2 NGFR PAX3 PAX7
24 renal/urinary system MP:0005367 9.8 MDM2 NF1 NF2 NGFR PAX3 PAX8
25 skeleton MP:0005390 9.7 CDKN2A MDM2 NF1 NF2 NGFR PAX3
26 vision/eye MP:0005391 9.28 CDKN2A NF1 NF2 NGFR PAX3 PAX7

Drugs & Therapeutics for Cellular Schwannoma

Search Clinical Trials , NIH Clinical Center for Cellular Schwannoma

Genetic Tests for Cellular Schwannoma

Anatomical Context for Cellular Schwannoma

MalaCards organs/tissues related to Cellular Schwannoma:

41
Skin, Bone, Brain, Breast, Spinal Cord, Thyroid, Uterus

Publications for Cellular Schwannoma

Articles related to Cellular Schwannoma:

(show top 50) (show all 63)
# Title Authors Year
1
Spinal cellular schwannoma: An analysis of imaging manifestation and clinicopathological findings. ( 30017303 )
2018
2
MR imaging of vaginal cellular schwannoma. ( 30195699 )
2018
3
Successful Excision of Endobronchial Cellular Schwannoma with Right Lower Sleeve Lobectomy. ( 30205116 )
2018
4
CHD4 as a Potential Biomarker in Differentiating Between Cellular Schwannoma and Malignant Peripheral Nerve Sheath Tumor. ( 28549031 )
2017
5
Infantile cellular schwannoma developing on the skin with atypical clinical features. ( 25232315 )
2014
6
Atypical presentation of sinonasal cellular schwannoma: a nonsolitary mass with osseous, orbital, and intracranial invasion. ( 25083375 )
2014
7
A recurrent cellular schwannoma. ( 25346907 )
2014
8
Cellular schwannoma arising from the gastric wall misdiagnosed as a gastric stromal tumor: A case report. ( 24396458 )
2014
9
Primary pleural hybrid cellular schwannoma/perineurioma: a case report. ( 24998375 )
2014
10
Cellular schwannoma of the retroperitoneum with cystic degeneration, mimicking an ovarian cyst, with CKAE1/AE3 and desmin expression. ( 25180931 )
2014
11
Spontaneous acute hemorrhage of intraspinal canal cellular schwannoma with paraplegia: A case report. ( 25488387 )
2014
12
An unusual location for cellular schwannoma. ( 24718004 )
2014
13
Cellular schwannoma masquerading as malignant peripheral nerve sheath tumour: a diagnostic dilemma. ( 23709140 )
2013
14
Cellular schwannoma arising from sigmoid mesocolon presenting as torsion. ( 24349845 )
2013
15
A spinal epidural dumbbell cellular schwannoma in an infant. ( 22325076 )
2012
16
Low-back pain as the presenting sign in a patient with a giant, sacral cellular schwannoma: 10-year follow-up. ( 21214314 )
2011
17
Intrapulmonary cellular schwannoma. ( 20868846 )
2010
18
Trisomy 17 in congenital plexiform (multinodular) cellular schwannoma. ( 21156251 )
2010
19
Meningothelial-like whorls in a retroperitoneal cellular schwannoma: potential diagnostic pitfall. ( 20055955 )
2010
20
A huge cystic cellular schwannoma of the intercostal nerve presenting with dyspnea. ( 19324168 )
2009
21
Cellular schwannoma of the abducens nerve: case report and review of the literature. ( 19200646 )
2009
22
Non-healing ulcer on the great toe due to cellular schwannoma. ( 20055863 )
2009
23
Cellular schwannoma of the greater superficial petrosal nerve presenting with abducens nerve palsy and xerophthalmia: case report. ( 18981849 )
2008
24
A rare case of cellular schwannoma in the pharynx. ( 18306575 )
2007
25
Colocalized cellular schwannoma and plexiform neurofibroma in the absence of neurofibromatosis. Case report. ( 17695403 )
2007
26
Unusually large cellular schwannoma of the foot. ( 15778474 )
2005
27
Clonal chromosome abnormalities in a plexiform cellular schwannoma. ( 15041228 )
2004
28
Small juxtadrenal cellular schwannoma. ( 14634806 )
2004
29
Intrasellar and parasellar cellular schwannoma. ( 15185261 )
2004
30
Cellular schwannoma: report of a case diagnosed intraoperatively with the aid of cytologic imprints. ( 12889049 )
2003
31
Cellular schwannoma: a rare spinal benign nerve-sheath tumor with a pseudosarcomatous appearance: case report. ( 14762614 )
2003
32
A rare case of cellular schwannoma involving the trigeminal ganglion. ( 14756445 )
2003
33
Retrobulbar cellular schwannoma. Two cases report and review of the literature. ( 12812319 )
2003
34
Congenital and childhood plexiform (multinodular) cellular schwannoma: a troublesome mimic of malignant peripheral nerve sheath tumor. ( 14508393 )
2003
35
Cellular schwannoma of the posterior fossa. ( 11971068 )
2002
36
A case of cellular schwannoma of the skin presenting as a large ulcerated tumor on the ankle. ( 11837571 )
2002
37
Cellular schwannoma of the paranasal sinuses: initial report of a case. ( 11987747 )
2002
38
Cellular schwannoma in the oral mucosa. ( 12126009 )
2002
39
Cellular schwannoma: a rare presacral tumour. ( 11939658 )
2002
40
Cellular schwannoma: a benign neoplasm sometimes overdiagnosed as sarcoma. ( 11465777 )
2001
41
Cellular schwannoma of the mandible: a case report. ( 11429752 )
2001
42
Giant intrasacral cellular schwannoma treated with high sacral amputation. ( 11413442 )
2001
43
Cellular schwannoma mimics a sarcoma: an example of a potential pitfall in aspiration cytodiagnosis. ( 10319235 )
1999
44
Solitary cellular schwannoma (neurilemmoma) showing malignant changes: evaluation through magnetic resonance imaging (M.R.I.), surgical intervention, and histopathology. ( 10209928 )
1999
45
Solitary cellular schwannoma presenting with haemothorax. ( 10325881 )
1998
46
Retrovesical cellular schwannoma. ( 9117235 )
1997
47
Acoustic cellular schwannoma invading the petrous bone: case report. ( 8837812 )
1996
48
Cellular schwannoma of the mandible: a case report with ultrastructural and immunohistochemical observations. ( 8600243 )
1996
49
Cellular schwannoma: a clinicopathologic, DNA flow cytometric, and proliferation marker study of 70 patients. ( 8630970 )
1996
50
Cellular schwannoma of the bronchus. ( 8837342 )
1996

Variations for Cellular Schwannoma

Expression for Cellular Schwannoma

Search GEO for disease gene expression data for Cellular Schwannoma.

Pathways for Cellular Schwannoma

GO Terms for Cellular Schwannoma

Cellular components related to Cellular Schwannoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleoplasm GO:0005654 9.7 CDKN2A CHD4 MAML3 MDM2 NGFR PAX3
2 nucleus GO:0005634 9.55 CDKN2A CHD4 DSP MAML3 MDM2 NF1
3 cytoplasm GO:0005737 10 CD34 CDKN2A CHD4 DSP MDM2 NF1

Biological processes related to Cellular Schwannoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 negative regulation of apoptotic process GO:0043066 9.93 MDM2 NGFR PAX7 SOX10 TP53
2 positive regulation of gene expression GO:0010628 9.77 CD34 CDKN2A MDM2 SOX10 TP53
3 regulation of gene expression GO:0010468 9.76 MDM2 NF1 PAX7 SOX2
4 positive regulation of transcription, DNA-templated GO:0045893 9.73 CDKN2A PAX3 PAX8 SOX10 SOX2 TP53
5 positive regulation of apoptotic process GO:0043065 9.72 CDKN2A NF1 NGFR S100B TP53
6 negative regulation of protein kinase activity GO:0006469 9.65 CDKN2A NF1 NF2
7 Ras protein signal transduction GO:0007265 9.58 CDKN2A NF1 TP53
8 positive regulation of transcription by RNA polymerase II GO:0045944 9.56 CDKN2A MAML3 PAX3 PAX7 PAX8 SOX10
9 positive regulation of myelination GO:0031643 9.52 S100B SOX10
10 regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043281 9.51 NGFR SOX2
11 replicative senescence GO:0090399 9.49 CDKN2A TP53
12 amyloid fibril formation GO:1990000 9.43 CDKN2A MDM2
13 cellular response to actinomycin D GO:0072717 9.16 MDM2 TP53
14 negative regulation of cell-matrix adhesion GO:0001953 8.8 CDKN2A NF1 NF2

Molecular functions related to Cellular Schwannoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.88 PAX3 PAX7 PAX8 SOX10 SOX2 TP53
2 RNA polymerase II proximal promoter sequence-specific DNA binding GO:0000978 9.72 CHD4 PAX8 SOX10 SUZ12 TP53
3 identical protein binding GO:0042802 9.7 MDM2 S100A1 S100B SLC2A1 SOX10 TFG
4 transcription regulatory region DNA binding GO:0044212 9.67 PAX8 SOX10 SOX2 TP53
5 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 9.63 CHD4 SOX10 TP53
6 S100 protein binding GO:0044548 9.43 S100A1 S100B
7 promoter-specific chromatin binding GO:1990841 9.13 SOX10 SUZ12 TP53
8 disordered domain specific binding GO:0097718 8.8 CDKN2A MDM2 TP53
9 protein binding GO:0005515 10.19 CDKN2A CHD4 DSP MDM2 NF1 NF2

Sources for Cellular Schwannoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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