CCCA
MCID: CNT057
MIFTS: 36

Central Centrifugal Cicatricial Alopecia (CCCA)

Categories: Rare diseases

Aliases & Classifications for Central Centrifugal Cicatricial Alopecia

MalaCards integrated aliases for Central Centrifugal Cicatricial Alopecia:

Name: Central Centrifugal Cicatricial Alopecia 57 20 6 70 70
Central Centrifugal Alopecia 20
Ccca 57

Characteristics:

OMIM®:

57 (Updated 20-May-2021)
Inheritance:
autosomal dominant

Miscellaneous:
primarily affects women of african ancestry


HPO:

31
central centrifugal cicatricial alopecia:
Inheritance autosomal dominant inheritance


Classifications:



External Ids:

OMIM® 57 618352
MedGen 41 C1274708
SNOMED-CT via HPO 68 263681008
UMLS 70 C1274708 C2026059

Summaries for Central Centrifugal Cicatricial Alopecia

OMIM® : 57 Central centrifugal cicatricial alopecia (CCCA) is the most common type of primary scarring alopecia affecting women of African ancestry, with an estimated prevalence of 2.7 to 5.6%. It may be triggered by hair-grooming habits; however, familial occurrence has been reported. Mean age at presentation is 36 years. The first sign is often unexplained hair breakage, followed by hair thinning, primarily involving the vertex scalp and progressing centrifugally. Histopathologic examination shows varying degrees of lymphocytic inflammation, follicular degeneration, and fibrosis (Malki et al., 2019). (618352) (Updated 20-May-2021)

MalaCards based summary : Central Centrifugal Cicatricial Alopecia, also known as central centrifugal alopecia, is related to alopecia and alopecia areata. An important gene associated with Central Centrifugal Cicatricial Alopecia is PADI3 (Peptidyl Arginine Deiminase 3), and among its related pathways/superpathways is Keratinization. The drugs Apremilast and Fluocinonide have been mentioned in the context of this disorder. Affiliated tissues include skin, skeletal muscle and ovary, and related phenotypes are scarring alopecia of scalp and Increased shRNA abundance (Z-score > 2)

Wikipedia : 73 Central centrifugal cicatricial alopecia (CCCA), is a type of alopecia first noticed in African... more...

Related Diseases for Central Centrifugal Cicatricial Alopecia

Diseases related to Central Centrifugal Cicatricial Alopecia via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 25)
# Related Disease Score Top Affiliating Genes
1 alopecia 31.0 PADI3 KRT15
2 alopecia areata 10.5
3 frontal fibrosing alopecia 10.5
4 alopecia, androgenetic, 1 10.4
5 androgenic alopecia 10.4
6 hair whorl 10.3
7 discoid lupus erythematosus 10.3
8 colorectal cancer 10.2
9 anxiety 10.2
10 leiomyoma 10.2
11 keratosis 10.2
12 telogen effluvium 10.2
13 dermatitis 10.2
14 skin disease 10.2
15 systemic scleroderma 10.2
16 hair disease 10.2
17 tinea capitis 10.2
18 myofibroma 10.2
19 folliculitis 10.2
20 acne 10.2
21 seborrheic dermatitis 10.2
22 dermatophytosis 10.2
23 diabetes mellitus 10.2
24 quinquaud folliculitis decalvans 10.2
25 depression 10.2

Graphical network of the top 20 diseases related to Central Centrifugal Cicatricial Alopecia:



Diseases related to Central Centrifugal Cicatricial Alopecia

Symptoms & Phenotypes for Central Centrifugal Cicatricial Alopecia

Human phenotypes related to Central Centrifugal Cicatricial Alopecia:

31
# Description HPO Frequency HPO Source Accession
1 scarring alopecia of scalp 31 HP:0004552

Symptoms via clinical synopsis from OMIM®:

57 (Updated 20-May-2021)
Skin Nails Hair Skin Histology:
decreased hair-follicle density of scalp
perifollicular lymphocytic infiltration
areas of fibrosis

Skin Nails Hair Hair:
hair breakage
hair thinning at vertex scalp
progressive centrifugal loss of hair
perifollicular grayish halo on dermoscopy

Clinical features from OMIM®:

618352 (Updated 20-May-2021)

GenomeRNAi Phenotypes related to Central Centrifugal Cicatricial Alopecia according to GeneCards Suite gene sharing:

26 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-135 9.36 KRT75
2 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.36 KRT75
3 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.36 PADI3
4 Increased shRNA abundance (Z-score > 2) GR00366-A-168 9.36 PADI3
5 Increased shRNA abundance (Z-score > 2) GR00366-A-17 9.36 KRT75
6 Increased shRNA abundance (Z-score > 2) GR00366-A-180 9.36 KRT75
7 Increased shRNA abundance (Z-score > 2) GR00366-A-200 9.36 PADI3
8 Increased shRNA abundance (Z-score > 2) GR00366-A-43 9.36 PADI3
9 Increased shRNA abundance (Z-score > 2) GR00366-A-85 9.36 KRT75
10 Increased shRNA abundance (Z-score > 2) GR00366-A-87 9.36 PADI3
11 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.36 PADI3

Drugs & Therapeutics for Central Centrifugal Cicatricial Alopecia

Drugs for Central Centrifugal Cicatricial Alopecia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 36)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Apremilast Approved, Investigational Phase 4 608141-41-9 11561674
2
Fluocinonide Approved, Investigational Phase 4 356-12-7 9642
3
Minoxidil Approved, Investigational Phase 4 38304-91-5 4201
4
Triamcinolone Approved, Vet_approved Phase 4 124-94-7 31307
5
Doxycycline Approved, Investigational, Vet_approved Phase 4 564-25-0 54671203
6
Clobetasol Approved, Experimental, Investigational Phase 4 25122-46-7, 25122-41-2 32798 5311051
7
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
8 Dermatologic Agents Phase 4
9 Emollients Phase 4
10 Antirheumatic Agents Phase 4
11 Analgesics Phase 4
12 Anti-Inflammatory Agents, Non-Steroidal Phase 4
13 Analgesics, Non-Narcotic Phase 4
14 Respiratory System Agents Phase 4
15 Pharmaceutical Solutions Phase 4
16 Anti-Asthmatic Agents Phase 4
17 Vasodilator Agents Phase 4
18 Hormones Phase 4
19 Antibiotics, Antitubercular Phase 4
20 Triamcinolone hexacetonide Phase 4
21 Triamcinolone diacetate Phase 4
22 Immunosuppressive Agents Phase 4
23 Anti-Bacterial Agents Phase 4
24 Hormone Antagonists Phase 4
25 Immunologic Factors Phase 4
26 glucocorticoids Phase 4
27 triamcinolone acetonide Phase 4
28 Betamethasone benzoate Phase 4
29 Anti-Allergic Agents Phase 4
30 Anti-Inflammatory Agents Phase 4
31 Betamethasone-17,21-dipropionate Phase 4
32 Betamethasone sodium phosphate Phase 4
33 Antihypertensive Agents Phase 4
34 Betamethasone Valerate Phase 4 2152-44-5
35
Tretinoin Approved, Investigational, Nutraceutical Early Phase 1 302-79-4 5538 444795
36 Keratolytic Agents Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Clobetasol Propionate 0.05% E Foam in the Treatment of Central Centrifugal Cicatricial Alopecia Unknown status NCT01111981 Phase 4 Clobetasol Propionate 0.05% Emollient Foam
2 An Open-label Pilot Study to Investigate the Efficacy of Apremilast in the Treatment of Central Centrifugal Cicatricial Alopecia (CCCA) Completed NCT03521687 Phase 4 Apremilast
3 Treatment Results for Patients With Central Centrifugal Cicatricial Alopecia (CCCA): a Multicenter Prospective Study Recruiting NCT04207931 Phase 4 Topical steroid class I-II;Triamcinolone Acetonide;Doxycyline;Minoxidil
4 Barriers to Healthcare and Quality of Life for Central Centrifugal Cicatricial Alopecia Patients Completed NCT03044782
5 Pilot Exploratory Study to Determine Effect of Gentle Wounding to Stimulate Hair Follicle Neogenesis Enrolling by invitation NCT03491267 Early Phase 1 Retinoic acid;Sham treatment
6 Remote Ischemic Conditioning in Acute Ischemic Cerebral Vascular Disease Patients With Coexistence of Cerebral and Coronary Atherosclerosis(RIC-CCCA) Enrolling by invitation NCT03721692
7 A Pilot Study of Revian Red All LED Cap as a Novel Treatment for Central Centrifugal Cicatricial Alopecia. Not yet recruiting NCT04764331

Search NIH Clinical Center for Central Centrifugal Cicatricial Alopecia

Genetic Tests for Central Centrifugal Cicatricial Alopecia

Anatomical Context for Central Centrifugal Cicatricial Alopecia

MalaCards organs/tissues related to Central Centrifugal Cicatricial Alopecia:

40
Skin, Skeletal Muscle, Ovary, Breast, Brain, Heart

Publications for Central Centrifugal Cicatricial Alopecia

Articles related to Central Centrifugal Cicatricial Alopecia:

(show top 50) (show all 223)
# Title Authors PMID Year
1
Variant PADI3 in Central Centrifugal Cicatricial Alopecia. 6 61 57
30763140 2019
2
Central centrifugal cicatricial alopecia: what has been achieved, current clues for future research. 61 57
24680004 2014
3
Central centrifugal cicatricial alopecia: past, present, and future. 57 61
19293013 2009
4
Association of breast and colorectal cancer in patients with central centrifugal cicatricial alopecia: A retrospective, cross-sectional pilot study. 61
33470208 2021
5
Systematic Convergence of the Numerical Taylor Series to the Best Standard and Its Potential Implication for the Development of Composite Methods. 61
33689333 2021
6
Association of type 2 diabetes with central centrifugal cicatricial alopecia: A follow-up study. 61
33609590 2021
7
Central centrifugal cicatricial alopecia: Histologic progression correlates with advancing age. 61
33465433 2021
8
Hair stylists as Screeners for Scarring Hair Loss within the African American Community: A Cross Sectional Study. 61
33459357 2021
9
Critical benchmarking of popular composite thermochemistry models and density functional approximations on a probabilistically pruned benchmark dataset of formation enthalpies. 61
33514111 2021
10
Effects and Molecular Mechanism of Single-Nucleotide Polymorphisms of MEG3 on Porcine Skeletal Muscle Development. 61
33692824 2021
11
Comorbid anxiety and depression among black women with central centrifugal cicatricial alopecia: A retrospective study. 61
33180336 2021
12
Association of the sEH gene promoter polymorphisms and haplotypes with preeclampsia. 61
33312058 2020
13
Pili trianguli et canaliculi as a phenotypic subtype in patients with central centrifugal cicatricial alopecia: A scanning electron microscopy study. 61
32428609 2020
14
Central Centrifugal Cicatricial Alopecia. 61
32745206 2020
15
Probing the electronic structures and properties of neutral and charged FeSin(-1,0,+1) (n = 1-6) clusters using ccCA theory. 61
32974685 2020
16
Correlation between TICAM1 gene polymorphisms and community-acquired pneumonia in children. 61
32243044 2020
17
Dermatoscopic Evaluation of Central Centrifugal Cicatricial Alopecia Beyond the Vertex Scalp. 61
32609323 2020
18
The Use of Natural Ingredients in the Treatment of Alopecias with an Emphasis on Central Centrifugal Cicatricial Alopecia: A Systematic Review. 61
33178378 2020
19
Frontal Fibrosing Alopecia Presenting as Androgenetic Alopecia in an African American Woman. 61
32722912 2020
20
Novel Regional Activity Representation With Constrained Canonical Correlation Analysis for Brain Connectivity Network Estimation. 61
32011247 2020
21
Increased Association between Previous Pregnancies and Use of Chemical Relaxers in 74 Women with Central Centrifugal Cicatricial Alopecia. 61
33376287 2020
22
Safety and Efficacy of Clobetasol Propionate 0.05% Emollient Foam for the Treatment of Central Centrifugal Cicatricial Alopecia. 61
32726554 2020
23
Characterization of the inflammatory features of central centrifugal cicatricial alopecia. 61
32068905 2020
24
Plasma DNA End-Motif Profiling as a Fragmentomic Marker in Cancer, Pregnancy, and Transplantation. 61
32111602 2020
25
Use of Giemsa staining in the evaluation of central centrifugal cicatricial alopecia. 61
32065424 2020
26
Domain-based local pair natural orbital methods within the correlation consistent composite approach. 61
31891196 2020
27
Clinicopathologic and immunophenotypic characterization of lichen planopilaris and central centrifugal cicatricial alopecia: A comparative study of 51 cases. 61
31605498 2020
28
Hair regrowth in 2 patients with recalcitrant central centrifugal cicatricial alopecia after use of topical metformin. 61
32016152 2020
29
A proposed mechanism for central centrifugal cicatricial alopecia. 61
29660185 2020
30
Central Centrifugal Cicatricial Alopecia and Lichen Planopilaris Can Look Identical on Histopathology. 61
33397566 2020
31
Clinical recognition and management of alopecia in women of color. 61
31909150 2019
32
Updates in our understanding of central centrifugal cicatricial alopecia. 61
31939927 2019
33
Dilation of Multiple Eccrine Ducts as a Highly Specific Marker for Cicatricial Alopecia. 61
31764231 2019
34
Genetic analysis of 62 Chinese families with Duchenne muscular dystrophy and strategies of prenatal diagnosis in a single center. 61
31727011 2019
35
Central Centrifugal Cicatricial Alopecia in a Fair Phototype Patient. 61
32030062 2019
36
Central Centrifugal Cicatricial Alopecia Following a Patchy Pattern: A New Form of Clinical Presentation and a Challenging Diagnosis for the Dermatologist. 61
31728105 2019
37
Autosomal-Dominant Mutation in PADI3 Responsible for up to 25% of Central Centrifugal Cicatricial Alopecia Cases. 61
31478774 2019
38
Frequency of the Types of Alopecia at Twenty-Two Specialist Hair Clinics: A Multicenter Study. 61
31559256 2019
39
Premature Desquamation of the Inner Root Sheath in Noninflamed Hair Follicles as a Specific Marker for Central Centrifugal Cicatricial Alopecia. 61
30562220 2019
40
New pattern hair loss in young Turkish women; What's wrong in their daily life? 61
30614076 2019
41
A Systematic Review of the Outcome of Hair Transplantation in Primary Scarring Alopecia. 61
30815438 2019
42
Current and emerging treatment strategies for hair loss in women of color. 61
30809578 2019
43
Health care barriers and quality of life in central centrifugal cicatricial alopecia patients. 61
30657802 2018
44
Fibroproliferative genes are preferentially expressed in central centrifugal cicatricial alopecia. 61
29913259 2018
45
Preservation of Sebaceous Glands and PPARγ Expression in Central Centrifugal Cicatricial Alopecia. 61
30055201 2018
46
Naked Hair Shafts as a Marker of Cicatricial Alopecia. 61
29293128 2018
47
Cicatricial Alopecia in Identical Twin Lumbee Native American Women. 61
29888228 2018
48
Primary scarring alopecia: A retrospective study of 89 patients in Taiwan. 61
29341216 2018
49
Cicatricial Alopecia Research Foundation meeting, May 2016: Progress towards the diagnosis, treatment and cure of primary cicatricial alopecias. 61
29341265 2018
50
Association of Uterine Leiomyomas With Central Centrifugal Cicatricial Alopecia. 61
29282458 2018

Variations for Central Centrifugal Cicatricial Alopecia

ClinVar genetic disease variations for Central Centrifugal Cicatricial Alopecia:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 PADI3 NM_016233.2(PADI3):c.1744G>A (p.Ala582Thr) SNV Pathogenic 599195 rs34097903 GRCh37: 1:17607274-17607274
GRCh38: 1:17280779-17280779
2 PADI3 NM_016233.2(PADI3):c.1669C>T (p.Arg557Trp) SNV Pathogenic 599196 rs140482516 GRCh37: 1:17607199-17607199
GRCh38: 1:17280704-17280704
3 PADI3 NM_016233.2(PADI3):c.832-2A>G SNV Pathogenic 599197 rs1557508308 GRCh37: 1:17597372-17597372
GRCh38: 1:17270877-17270877
4 PADI3 NM_016233.2(PADI3):c.1955G>A (p.Arg652Lys) SNV Pathogenic 599198 rs1437225536 GRCh37: 1:17609534-17609534
GRCh38: 1:17283039-17283039
5 PADI3 NM_016233.2(PADI3):c.628C>T (p.Arg210Trp) SNV Pathogenic 599199 rs139876092 GRCh37: 1:17594433-17594433
GRCh38: 1:17267938-17267938
6 PADI3 NM_016233.2(PADI3):c.856A>G (p.Thr286Ala) SNV Pathogenic 599194 rs139426141 GRCh37: 1:17597398-17597398
GRCh38: 1:17270903-17270903

Expression for Central Centrifugal Cicatricial Alopecia

Search GEO for disease gene expression data for Central Centrifugal Cicatricial Alopecia.

Pathways for Central Centrifugal Cicatricial Alopecia

Pathways related to Central Centrifugal Cicatricial Alopecia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.08 KRT75 KRT15

GO Terms for Central Centrifugal Cicatricial Alopecia

Cellular components related to Central Centrifugal Cicatricial Alopecia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.62 KRT75 KRT15

Biological processes related to Central Centrifugal Cicatricial Alopecia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 8.96 KRT75 KRT15
2 cornification GO:0070268 8.62 KRT75 KRT15

Molecular functions related to Central Centrifugal Cicatricial Alopecia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.62 KRT75 KRT15

Sources for Central Centrifugal Cicatricial Alopecia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....