CCCA
MCID: CNT057
MIFTS: 31

Central Centrifugal Cicatricial Alopecia (CCCA)

Categories: Rare diseases

Aliases & Classifications for Central Centrifugal Cicatricial Alopecia

MalaCards integrated aliases for Central Centrifugal Cicatricial Alopecia:

Name: Central Centrifugal Cicatricial Alopecia 58 54 6 74 74
Central Centrifugal Alopecia 54
Ccca 58

Characteristics:

OMIM:

58
Inheritance:
autosomal dominant

Miscellaneous:
primarily affects women of african ancestry


Classifications:



External Ids:

OMIM 58 618352

Summaries for Central Centrifugal Cicatricial Alopecia

OMIM : 58 Central centrifugal cicatricial alopecia (CCCA) is the most common type of primary scarring alopecia affecting women of African ancestry, with an estimated prevalence of 2.7 to 5.6%. It may be triggered by hair-grooming habits; however, familial occurrence has been reported. Mean age at presentation is 36 years. The first sign is often unexplained hair breakage, followed by hair thinning, primarily involving the vertex scalp and progressing centrifugally. Histopathologic examination shows varying degrees of lymphocytic inflammation, follicular degeneration, and fibrosis (Malki et al., 2019). (618352)

MalaCards based summary : Central Centrifugal Cicatricial Alopecia, also known as central centrifugal alopecia, is related to alopecia and retinitis pigmentosa. An important gene associated with Central Centrifugal Cicatricial Alopecia is PADI3 (Peptidyl Arginine Deiminase 3), and among its related pathways/superpathways is Keratinization. The drugs Clobetasol and Apremilast have been mentioned in the context of this disorder. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 77 Central centrifugal cicatricial alopecia (CCCA), is a type of alopecia first noticed in African... more...

Related Diseases for Central Centrifugal Cicatricial Alopecia

Diseases related to Central Centrifugal Cicatricial Alopecia via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 alopecia 11.0
2 retinitis pigmentosa 10.3
3 alopecia, androgenetic, 1 10.2
4 androgenic alopecia 10.2
5 dermatitis 10.2
6 tinea capitis 10.2
7 dermatophytosis 10.2
8 alopecia areata 10.2
9 leukemia 10.1

Graphical network of the top 20 diseases related to Central Centrifugal Cicatricial Alopecia:



Diseases related to Central Centrifugal Cicatricial Alopecia

Symptoms & Phenotypes for Central Centrifugal Cicatricial Alopecia

Symptoms via clinical synopsis from OMIM:

58
Skin Nails Hair Skin Histology:
decreased hair-follicle density of scalp
perifollicular lymphocytic infiltration
areas of fibrosis

Skin Nails Hair Hair:
hair breakage
hair thinning at vertex scalp
progressive centrifugal loss of hair
perifollicular grayish halo on dermoscopy

Clinical features from OMIM:

618352

GenomeRNAi Phenotypes related to Central Centrifugal Cicatricial Alopecia according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.23 KRT75 PADI3
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.23 KRT75
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.23 KRT75
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.23 KRT75
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.23 PADI3
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.23 PADI3
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.23 KRT75

Drugs & Therapeutics for Central Centrifugal Cicatricial Alopecia

Drugs for Central Centrifugal Cicatricial Alopecia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clobetasol Approved, Experimental, Investigational Phase 4 25122-46-7, 25122-41-2 5311051 32798
2
Apremilast Approved, Investigational Phase 4 608141-41-9 11561674
3 Hormone Antagonists Phase 4
4 Hormones Phase 4
5 Emollients Phase 4
6 glucocorticoids Phase 4
7 Dermatologic Agents Phase 4,Early Phase 1
8 Anti-Inflammatory Agents Phase 4
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
10 Anti-Inflammatory Agents, Non-Steroidal Phase 4
11 Anti-Infective Agents Phase 4
12 Analgesics, Non-Narcotic Phase 4
13 Anti-Bacterial Agents Phase 4
14 Peripheral Nervous System Agents Phase 4,Early Phase 1
15 Antirheumatic Agents Phase 4
16 Immunosuppressive Agents Phase 4
17 Angiogenesis Inhibitors Phase 4
18 Immunologic Factors Phase 4
19 Angiogenesis Modulating Agents Phase 4
20 Analgesics Phase 4,Early Phase 1
21
Gabapentin Approved, Investigational Early Phase 1 60142-96-3 3446
22
Tretinoin Approved, Investigational, Nutraceutical Early Phase 1 302-79-4 444795 5538
23 Anti-Anxiety Agents Early Phase 1
24 Central Nervous System Depressants Early Phase 1
25 Excitatory Amino Acids Early Phase 1
26 Neurotransmitter Agents Early Phase 1
27 Excitatory Amino Acid Antagonists Early Phase 1
28 Psychotropic Drugs Early Phase 1
29 Tranquilizing Agents Early Phase 1
30 Antimanic Agents Early Phase 1
31 Pharmaceutical Solutions Early Phase 1
32 Anticonvulsants Early Phase 1
33 Keratolytic Agents Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Clobetasol Propionate 0.05% E Foam in Alopecia Unknown status NCT01111981 Phase 4 Clobetasol Propionate 0.05% Emollient Foam
2 Apremilast in the Treatment of Central Centrifugal Cicatricial Alopecia (CCCA) Recruiting NCT03521687 Phase 4 Apremilast
3 Barriers to Care and QOL for CCCA Patients Completed NCT03044782
4 Role of Neurogenic Inflammation and Topical 6% Gabapentin Therapy in Symptomatic Scarring Alopecia Recruiting NCT03346668 Early Phase 1 Topical gabapentin
5 Study to Determine Effect of Gentle Wounding to Stimulate Hair Follicle Neogenesis Enrolling by invitation NCT03491267 Early Phase 1 Retinoic acid;Sham treatment

Search NIH Clinical Center for Central Centrifugal Cicatricial Alopecia

Genetic Tests for Central Centrifugal Cicatricial Alopecia

Anatomical Context for Central Centrifugal Cicatricial Alopecia

Publications for Central Centrifugal Cicatricial Alopecia

Articles related to Central Centrifugal Cicatricial Alopecia:

(show top 50) (show all 58)
# Title Authors Year
1
Variant PADI3 in Central Centrifugal Cicatricial Alopecia. ( 30763140 )
2019
2
Premature Desquamation of the Inner Root Sheath in Noninflamed Hair Follicles as a Specific Marker for Central Centrifugal Cicatricial Alopecia. ( 30562220 )
2019
3
Health care barriers and quality of life in central centrifugal cicatricial alopecia patients. ( 30657802 )
2018
4
Fibroproliferative genes are preferentially expressed in central centrifugal cicatricial alopecia. ( 29913259 )
2018
5
Preservation of Sebaceous Glands and PPARγ Expression in Central Centrifugal Cicatricial Alopecia. ( 30055201 )
2018
6
A proposed mechanism for central centrifugal cicatricial alopecia. ( 29660185 )
2018
7
Association of Uterine Leiomyomas With Central Centrifugal Cicatricial Alopecia. ( 29282458 )
2018
8
Central Centrifugal Cicatricial Alopecia: New Insights and a Call for Action. ( 28941495 )
2017
9
Alopecia Areata on Vertex as a Potential Pitfall for Misdiagnosis of Central Centrifugal Cicatricial Alopecia in African-American Women. ( 28839392 )
2017
10
Central Centrifugal Cicatricial Alopecia in Children: A Case Series and Review of the Literature. ( 27981623 )
2017
11
A Probable Case of Central Centrifugal Cicatricial Alopecia Encountered in Mark Twain's Autobiography. ( 27532356 )
2016
12
Central centrifugal cicatricial alopecia: challenges and solutions. ( 27574457 )
2016
13
Factors affecting the severity of central centrifugal cicatricial alopecia. ( 26769173 )
2016
14
Central Centrifugal Cicatricial Alopecia Presenting with Irregular Patchy Alopecia on the Lateral and Posterior Scalp. ( 27172374 )
2015
15
Pseudopotential-Based Correlation Consistent Composite Approach (rp-ccCA) for First- and Second-Row Transition Metal Thermochemistry. ( 26000954 )
2015
16
Cytochrome c biogenesis in Campylobacter jejuni requires cytochrome c6 (CccA; Cj1153) to maintain apocytochrome cysteine thiols in a reduced state for haem attachment. ( 25825009 )
2015
17
Hair transplantation in the surgical treatment of central centrifugal cicatricial alopecia. ( 25207763 )
2014
18
Pathologic diagnosis of central centrifugal cicatricial alopecia on horizontal sections. ( 25222198 )
2014
19
Dermatoscopic features of central centrifugal cicatricial alopecia. ( 24929886 )
2014
20
Autosomal dominant inheritance of central centrifugal cicatricial alopecia in black South Africans. ( 24480456 )
2014
21
Central centrifugal cicatricial alopecia: what has been achieved, current clues for future research. ( 24680004 )
2014
22
Probing the electronic structures and properties of neutral and anionic ScSi(n)((0,-1)) (n = 1-6) clusters using ccCA-TM and G4 theory. ( 24515721 )
2014
23
Solv-ccCA: Implicit Solvation and the Correlation Consistent Composite Approach for the Determination of pKa. ( 26580366 )
2014
24
Central centrifugal cicatricial alopecia. ( 23440368 )
2013
25
Central centrifugal cicatricial alopecia severity is associated with cowhage-induced itch. ( 22985403 )
2013
26
A critical role for the cccA gene product, cytochrome c2, in diverting electrons from aerobic respiration to denitrification in Neisseria gonorrhoeae. ( 23543713 )
2013
27
Explicitly Correlated Methods within the ccCA Methodology. ( 26587602 )
2013
28
Central centrifugal cicatricial alopecia: possible familial aetiology in two African families from South Africa. ( 23210944 )
2012
29
Differentiating central centrifugal cicatricial alopecia and androgenetic alopecia in african american men: report of three cases. ( 22768355 )
2012
30
Hair breakage as a presenting sign of early or occult central centrifugal cicatricial alopecia: clinicopathologic findings in 9 patients. ( 22986858 )
2012
31
Traction: risk factor or coincidence in central centrifugal cicatricial alopecia? ( 22578250 )
2012
32
Examining the heavy p-block with a pseudopotential-based composite method: atomic and molecular applications of rp-ccCA. ( 23231221 )
2012
33
Proton affinities of deoxyribonucleosides via the ONIOM-ccCA methodology. ( 22941806 )
2012
34
Prevalence of central centrifugal cicatricial alopecia. ( 22184774 )
2011
35
Prevalence and etiology of central centrifugal cicatricial alopecia. ( 21844458 )
2011
36
Central centrifugal cicatricial alopecia - an approach to diagnosis and management. ( 22097988 )
2011
37
Cytokeratin 15 expression in central, centrifugal, cicatricial alopecia: new observations in normal and diseased hair follicles. ( 21251039 )
2011
38
Medical and environmental risk factors for the development of central centrifugal cicatricial alopecia: a population study. ( 21482861 )
2011
39
Primary follicular dystrophy with scarring dermatitis in C57BL/6 mouse substrains resembles central centrifugal cicatricial alopecia in humans. ( 20861494 )
2011
40
Highly energetic nitrogen species: reliable energetics via the correlation consistent Composite Approach (ccCA). ( 21146298 )
2011
41
Oxidative addition of the Cα-Cβ bond in β-O-4 linkage of lignin to transition metals using a relativistic pseudopotential-based ccCA-ONIOM method. ( 22144374 )
2011
42
Central centrifugal cicatricial alopecia: retrospective chart review. ( 20868618 )
2010
43
Grooming and central centrifugal cicatricial alopecia. ( 20159316 )
2010
44
Cytokeratin 75 expression in central, centrifugal, cicatricial alopecia--new observations in normal and diseased hair follicles. ( 19614992 )
2010
45
Multireference correlation consistent composite approach [MR-ccCA]: toward accurate prediction of the energetics of excited and transition state chemistry. ( 20560594 )
2010
46
A QM/QM multilayer composite methodology: The ONIOM correlation consistent composite approach (ONIOM-ccCA). ( 20701242 )
2010
47
Hair grooming practices and central centrifugal cicatricial alopecia. ( 19293007 )
2009
48
Central centrifugal cicatricial alopecia: past, present, and future. ( 19293013 )
2009
49
Central centrifugal cicatricial alopecia: Superimposed tinea capitis as the etiology of chronic scalp pruritus. ( 19094841 )
2008
50
Central centrifugal cicatricial alopecia. ( 18715297 )
2008

Variations for Central Centrifugal Cicatricial Alopecia

ClinVar genetic disease variations for Central Centrifugal Cicatricial Alopecia:

6 (show all 12)
# Gene Variation Type Significance SNP ID Assembly Location
1 PADI3 NM_016233.2(PADI3): c.628C> T (p.Arg210Trp) single nucleotide variant Pathogenic rs139876092 GRCh37 Chromosome 1, 17594433: 17594433
2 PADI3 NM_016233.2(PADI3): c.628C> T (p.Arg210Trp) single nucleotide variant Pathogenic rs139876092 GRCh38 Chromosome 1, 17267938: 17267938
3 PADI3 NM_016233.2(PADI3): c.832-2A> G single nucleotide variant Pathogenic GRCh37 Chromosome 1, 17597372: 17597372
4 PADI3 NM_016233.2(PADI3): c.832-2A> G single nucleotide variant Pathogenic GRCh38 Chromosome 1, 17270877: 17270877
5 PADI3 NM_016233.2(PADI3): c.856A> G (p.Thr286Ala) single nucleotide variant Pathogenic rs139426141 GRCh37 Chromosome 1, 17597398: 17597398
6 PADI3 NM_016233.2(PADI3): c.856A> G (p.Thr286Ala) single nucleotide variant Pathogenic rs139426141 GRCh38 Chromosome 1, 17270903: 17270903
7 PADI3 NM_016233.2(PADI3): c.1669C> T (p.Arg557Trp) single nucleotide variant Pathogenic rs140482516 GRCh37 Chromosome 1, 17607199: 17607199
8 PADI3 NM_016233.2(PADI3): c.1669C> T (p.Arg557Trp) single nucleotide variant Pathogenic rs140482516 GRCh38 Chromosome 1, 17280704: 17280704
9 PADI3 NM_016233.2(PADI3): c.1744G> A (p.Ala582Thr) single nucleotide variant Pathogenic rs34097903 GRCh37 Chromosome 1, 17607274: 17607274
10 PADI3 NM_016233.2(PADI3): c.1744G> A (p.Ala582Thr) single nucleotide variant Pathogenic rs34097903 GRCh38 Chromosome 1, 17280779: 17280779
11 PADI3 NM_016233.2(PADI3): c.1955G> A (p.Arg652Lys) single nucleotide variant Pathogenic GRCh37 Chromosome 1, 17609534: 17609534
12 PADI3 NM_016233.2(PADI3): c.1955G> A (p.Arg652Lys) single nucleotide variant Pathogenic GRCh38 Chromosome 1, 17283039: 17283039

Expression for Central Centrifugal Cicatricial Alopecia

Search GEO for disease gene expression data for Central Centrifugal Cicatricial Alopecia.

Pathways for Central Centrifugal Cicatricial Alopecia

Pathways related to Central Centrifugal Cicatricial Alopecia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.08 KRT15 KRT75

GO Terms for Central Centrifugal Cicatricial Alopecia

Cellular components related to Central Centrifugal Cicatricial Alopecia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.62 KRT15 KRT75

Biological processes related to Central Centrifugal Cicatricial Alopecia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 8.96 KRT15 KRT75
2 cornification GO:0070268 8.62 KRT15 KRT75

Sources for Central Centrifugal Cicatricial Alopecia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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