MCID: CNT057
MIFTS: 23

Central Centrifugal Cicatricial Alopecia

Categories: Rare diseases

Aliases & Classifications for Central Centrifugal Cicatricial Alopecia

MalaCards integrated aliases for Central Centrifugal Cicatricial Alopecia:

Name: Central Centrifugal Cicatricial Alopecia 53 73 73
Central Centrifugal Alopecia 53

Classifications:



External Ids:

Summaries for Central Centrifugal Cicatricial Alopecia

MalaCards based summary : Central Centrifugal Cicatricial Alopecia, also known as central centrifugal alopecia, is related to alopecia and alopecia, androgenetic, 1. An important gene associated with Central Centrifugal Cicatricial Alopecia is KRT15 (Keratin 15), and among its related pathways/superpathways are Developmental Biology and Keratinization. The drugs Clobetasol and Apremilast have been mentioned in the context of this disorder.

Wikipedia : 76 Central centrifugal cicatricial alopecia (CCCA), also referred to as hot comb alopecia and follicular... more...

Related Diseases for Central Centrifugal Cicatricial Alopecia

Diseases related to Central Centrifugal Cicatricial Alopecia via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 alopecia 10.9
2 alopecia, androgenetic, 1 10.2
3 androgenic alopecia 10.2
4 dermatitis 10.2
5 tinea capitis 10.2
6 alopecia areata 10.2

Graphical network of the top 20 diseases related to Central Centrifugal Cicatricial Alopecia:



Diseases related to Central Centrifugal Cicatricial Alopecia

Symptoms & Phenotypes for Central Centrifugal Cicatricial Alopecia

Drugs & Therapeutics for Central Centrifugal Cicatricial Alopecia

Drugs for Central Centrifugal Cicatricial Alopecia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 38)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clobetasol Approved, Experimental, Investigational Phase 4 25122-46-7, 25122-41-2 5311051 32798
2
Apremilast Approved, Investigational Phase 4 608141-41-9 11561674
3 Anti-Inflammatory Agents Phase 4
4 Hormone Antagonists Phase 4
5 Hormones Phase 4
6 Emollients Phase 4
7 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
8 Dermatologic Agents Phase 4,Early Phase 1
9 glucocorticoids Phase 4
10 Immunologic Factors Phase 4
11 Analgesics Phase 4,Early Phase 1
12 Antirheumatic Agents Phase 4
13 Peripheral Nervous System Agents Phase 4,Early Phase 1
14 Anti-Inflammatory Agents, Non-Steroidal Phase 4
15 Analgesics, Non-Narcotic Phase 4
16 Anti-Bacterial Agents Phase 4
17 Anti-Infective Agents Phase 4
18 Angiogenesis Inhibitors Phase 4
19 Angiogenesis Modulating Agents Phase 4
20 Immunosuppressive Agents Phase 4
21
Gabapentin Approved, Investigational Early Phase 1 60142-96-3 3446
22
gamma-Aminobutyric acid Approved, Investigational Early Phase 1 56-12-2 119
23
Tretinoin Approved, Investigational, Nutraceutical Early Phase 1 302-79-4 5538 444795
24 Anti-Anxiety Agents Early Phase 1
25 Excitatory Amino Acids Early Phase 1
26 calcium channel blockers Early Phase 1
27 Antiparkinson Agents Early Phase 1
28 GABA Agents Early Phase 1
29 Neurotransmitter Agents Early Phase 1
30 Excitatory Amino Acid Antagonists Early Phase 1
31 Tranquilizing Agents Early Phase 1
32 Pharmaceutical Solutions Early Phase 1
33 Calcium, Dietary Early Phase 1
34 Anticonvulsants Early Phase 1
35 Psychotropic Drugs Early Phase 1
36 Central Nervous System Depressants Early Phase 1
37 Antimanic Agents Early Phase 1
38 Keratolytic Agents Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Clobetasol Propionate 0.05% E Foam in Alopecia Unknown status NCT01111981 Phase 4 Clobetasol Propionate 0.05% Emollient Foam
2 Apremilast in the Treatment of Central Centrifugal Cicatricial Alopecia (CCCA) Recruiting NCT03521687 Phase 4 Apremilast
3 Barriers to Care and QOL for CCCA Patients Completed NCT03044782
4 Role of Neurogenic Inflammation and Topical 6% Gabapentin Therapy in Symptomatic Scarring Alopecia Recruiting NCT03346668 Early Phase 1 Topical gabapentin
5 Study to Determine Effect of Gentle Wounding to Stimulate Hair Follicle Neogenesis Enrolling by invitation NCT03491267 Early Phase 1 Retinoic acid;Sham treatment

Search NIH Clinical Center for Central Centrifugal Cicatricial Alopecia

Genetic Tests for Central Centrifugal Cicatricial Alopecia

Anatomical Context for Central Centrifugal Cicatricial Alopecia

Publications for Central Centrifugal Cicatricial Alopecia

Articles related to Central Centrifugal Cicatricial Alopecia:

(show all 34)
# Title Authors Year
1
Association of Uterine Leiomyomas With Central Centrifugal Cicatricial Alopecia. ( 29282458 )
2018
2
Fibroproliferative Genes are Preferentially Expressed in Central Centrifugal Cicatricial Alopecia. ( 29913259 )
2018
3
A proposed mechanism for central centrifugal cicatricial alopecia. ( 29660185 )
2018
4
Preservation of Sebaceous Glands and PPARγ Expression in Central Centrifugal Cicatricial Alopecia. ( 30055201 )
2018
5
Alopecia Areata on Vertex as a Potential Pitfall for Misdiagnosis of Central Centrifugal Cicatricial Alopecia in African-American Women. ( 28839392 )
2017
6
Central Centrifugal Cicatricial Alopecia: New Insights and a Call for Action. ( 28941495 )
2017
7
A Probable Case of Central Centrifugal Cicatricial Alopecia Encountered in Mark Twain's Autobiography. ( 27532356 )
2016
8
Factors affecting the severity of central centrifugal cicatricial alopecia. ( 26769173 )
2016
9
Central centrifugal cicatricial alopecia: challenges and solutions. ( 27574457 )
2016
10
Central Centrifugal Cicatricial Alopecia in Children: A Case Series and Review of the Literature. ( 27981623 )
2016
11
Central Centrifugal Cicatricial Alopecia Presenting with Irregular Patchy Alopecia on the Lateral and Posterior Scalp. ( 27172374 )
2015
12
Pathologic diagnosis of central centrifugal cicatricial alopecia on horizontal sections. ( 25222198 )
2014
13
Hair transplantation in the surgical treatment of central centrifugal cicatricial alopecia. ( 25207763 )
2014
14
Central centrifugal cicatricial alopecia: what has been achieved, current clues for future research. ( 24680004 )
2014
15
Dermatoscopic features of central centrifugal cicatricial alopecia. ( 24929886 )
2014
16
Central centrifugal cicatricial alopecia. ( 23440368 )
2013
17
Central centrifugal cicatricial alopecia severity is associated with cowhage-induced itch. ( 22985403 )
2013
18
Differentiating central centrifugal cicatricial alopecia and androgenetic alopecia in african american men: report of three cases. ( 22768355 )
2012
19
Central centrifugal cicatricial alopecia: possible familial aetiology in two African families from South Africa. ( 23210944 )
2012
20
Traction: risk factor or coincidence in central centrifugal cicatricial alopecia? ( 22578250 )
2012
21
Hair breakage as a presenting sign of early or occult central centrifugal cicatricial alopecia: clinicopathologic findings in 9 patients. ( 22986858 )
2012
22
Primary follicular dystrophy with scarring dermatitis in C57BL/6 mouse substrains resembles central centrifugal cicatricial alopecia in humans. ( 20861494 )
2011
23
Cytokeratin 15 expression in central, centrifugal, cicatricial alopecia: new observations in normal and diseased hair follicles. ( 21251039 )
2011
24
Central centrifugal cicatricial alopecia - an approach to diagnosis and management. ( 22097988 )
2011
25
Prevalence and etiology of central centrifugal cicatricial alopecia. ( 21844458 )
2011
26
Prevalence of central centrifugal cicatricial alopecia. ( 22184774 )
2011
27
Medical and environmental risk factors for the development of central centrifugal cicatricial alopecia: a population study. ( 21482861 )
2011
28
Cytokeratin 75 expression in central, centrifugal, cicatricial alopecia--new observations in normal and diseased hair follicles. ( 19614992 )
2010
29
Central centrifugal cicatricial alopecia: retrospective chart review. ( 20868618 )
2010
30
Grooming and central centrifugal cicatricial alopecia. ( 20159316 )
2010
31
Hair grooming practices and central centrifugal cicatricial alopecia. ( 19293007 )
2009
32
Central centrifugal cicatricial alopecia: past, present, and future. ( 19293013 )
2009
33
Central centrifugal cicatricial alopecia: Superimposed tinea capitis as the etiology of chronic scalp pruritus. ( 19094841 )
2008
34
Central centrifugal cicatricial alopecia. ( 18715297 )
2008

Variations for Central Centrifugal Cicatricial Alopecia

Expression for Central Centrifugal Cicatricial Alopecia

Search GEO for disease gene expression data for Central Centrifugal Cicatricial Alopecia.

Pathways for Central Centrifugal Cicatricial Alopecia

Pathways related to Central Centrifugal Cicatricial Alopecia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.17 KRT15 KRT75
2
Show member pathways
11.08 KRT15 KRT75

GO Terms for Central Centrifugal Cicatricial Alopecia

Cellular components related to Central Centrifugal Cicatricial Alopecia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.62 KRT15 KRT75

Biological processes related to Central Centrifugal Cicatricial Alopecia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 8.96 KRT15 KRT75
2 cornification GO:0070268 8.62 KRT15 KRT75

Sources for Central Centrifugal Cicatricial Alopecia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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