CCCA
MCID: CNT057
MIFTS: 28

Central Centrifugal Cicatricial Alopecia (CCCA)

Categories: Rare diseases

Aliases & Classifications for Central Centrifugal Cicatricial Alopecia

MalaCards integrated aliases for Central Centrifugal Cicatricial Alopecia:

Name: Central Centrifugal Cicatricial Alopecia 58 54 6 74 74
Central Centrifugal Alopecia 54
Ccca 58

Classifications:



External Ids:

OMIM 58 618352

Summaries for Central Centrifugal Cicatricial Alopecia

OMIM : 58 Central centrifugal cicatricial alopecia (CCCA) is the most common type of primary scarring alopecia affecting women of African ancestry, with an estimated prevalence of 2.7 to 5.6%. It may be triggered by hair-grooming habits; however, familial occurrence has been reported. Mean age at presentation is 36 years. The first sign is often unexplained hair breakage, followed by hair thinning, primarily involving the vertex scalp and progressing centrifugally. Histopathologic examination shows varying degrees of lymphocytic inflammation, follicular degeneration, and fibrosis (Malki et al., 2019). (618352)

MalaCards based summary : Central Centrifugal Cicatricial Alopecia, also known as central centrifugal alopecia, is related to alopecia and retinitis pigmentosa. An important gene associated with Central Centrifugal Cicatricial Alopecia is PADI3 (Peptidyl Arginine Deiminase 3), and among its related pathways/superpathways is Keratinization. The drugs Clobetasol and Apremilast have been mentioned in the context of this disorder. Related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Wikipedia : 77 Central centrifugal cicatricial alopecia (CCCA), also referred to as hot comb alopecia and follicular... more...

Related Diseases for Central Centrifugal Cicatricial Alopecia

Diseases related to Central Centrifugal Cicatricial Alopecia via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 alopecia 11.0
2 retinitis pigmentosa 10.3
3 alopecia, androgenetic, 1 10.2
4 androgenic alopecia 10.2
5 dermatitis 10.2
6 tinea capitis 10.2
7 alopecia areata 10.2

Graphical network of the top 20 diseases related to Central Centrifugal Cicatricial Alopecia:



Diseases related to Central Centrifugal Cicatricial Alopecia

Symptoms & Phenotypes for Central Centrifugal Cicatricial Alopecia

Clinical features from OMIM:

618352

GenomeRNAi Phenotypes related to Central Centrifugal Cicatricial Alopecia according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-148 9.23 KRT75 PADI3
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-167 9.23 KRT75
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-17 9.23 KRT75
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-180 9.23 KRT75
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-200 9.23 PADI3
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-87 9.23 PADI3
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-89 9.23 KRT75

Drugs & Therapeutics for Central Centrifugal Cicatricial Alopecia

Drugs for Central Centrifugal Cicatricial Alopecia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 33)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Clobetasol Approved, Experimental, Investigational Phase 4 25122-46-7, 25122-41-2 32798 5311051
2
Apremilast Approved, Investigational Phase 4 608141-41-9 11561674
3 Anti-Inflammatory Agents Phase 4
4 Hormones Phase 4
5 Hormone Antagonists Phase 4
6 Emollients Phase 4
7 Dermatologic Agents Phase 4,Early Phase 1
8 glucocorticoids Phase 4
9 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4
10 Analgesics, Non-Narcotic Phase 4
11 Antirheumatic Agents Phase 4
12 Analgesics Phase 4,Early Phase 1
13 Immunologic Factors Phase 4
14 Anti-Infective Agents Phase 4
15 Anti-Inflammatory Agents, Non-Steroidal Phase 4
16 Immunosuppressive Agents Phase 4
17 Anti-Bacterial Agents Phase 4
18 Angiogenesis Modulating Agents Phase 4
19 Peripheral Nervous System Agents Phase 4,Early Phase 1
20 Angiogenesis Inhibitors Phase 4
21
Gabapentin Approved, Investigational Early Phase 1 60142-96-3 3446
22
Tretinoin Approved, Investigational, Nutraceutical Early Phase 1 302-79-4 5538 444795
23 Antimanic Agents Early Phase 1
24 Central Nervous System Depressants Early Phase 1
25 Excitatory Amino Acid Antagonists Early Phase 1
26 Neurotransmitter Agents Early Phase 1
27 Psychotropic Drugs Early Phase 1
28 Anti-Anxiety Agents Early Phase 1
29 Anticonvulsants Early Phase 1
30 Excitatory Amino Acids Early Phase 1
31 Pharmaceutical Solutions Early Phase 1
32 Tranquilizing Agents Early Phase 1
33 Keratolytic Agents Early Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Safety and Efficacy of Clobetasol Propionate 0.05% E Foam in Alopecia Unknown status NCT01111981 Phase 4 Clobetasol Propionate 0.05% Emollient Foam
2 Apremilast in the Treatment of Central Centrifugal Cicatricial Alopecia (CCCA) Recruiting NCT03521687 Phase 4 Apremilast
3 Barriers to Care and QOL for CCCA Patients Completed NCT03044782
4 Role of Neurogenic Inflammation and Topical 6% Gabapentin Therapy in Symptomatic Scarring Alopecia Recruiting NCT03346668 Early Phase 1 Topical gabapentin
5 Study to Determine Effect of Gentle Wounding to Stimulate Hair Follicle Neogenesis Enrolling by invitation NCT03491267 Early Phase 1 Retinoic acid;Sham treatment

Search NIH Clinical Center for Central Centrifugal Cicatricial Alopecia

Genetic Tests for Central Centrifugal Cicatricial Alopecia

Anatomical Context for Central Centrifugal Cicatricial Alopecia

Publications for Central Centrifugal Cicatricial Alopecia

Articles related to Central Centrifugal Cicatricial Alopecia:

(show all 37)
# Title Authors Year
1
Variant PADI3 in Central Centrifugal Cicatricial Alopecia. ( 30763140 )
2019
2
Association of Uterine Leiomyomas With Central Centrifugal Cicatricial Alopecia. ( 29282458 )
2018
3
Fibroproliferative Genes are Preferentially Expressed in Central Centrifugal Cicatricial Alopecia. ( 29913259 )
2018
4
A proposed mechanism for central centrifugal cicatricial alopecia. ( 29660185 )
2018
5
Premature Desquamation of the Inner Root Sheath in Noninflamed Hair Follicles as a Specific Marker for Central Centrifugal Cicatricial Alopecia. ( 30562220 )
2018
6
Health care barriers and quality of life in central centrifugal cicatricial alopecia patients. ( 30657802 )
2018
7
Preservation of Sebaceous Glands and PPARγ Expression in Central Centrifugal Cicatricial Alopecia. ( 30055201 )
2018
8
Alopecia Areata on Vertex as a Potential Pitfall for Misdiagnosis of Central Centrifugal Cicatricial Alopecia in African-American Women. ( 28839392 )
2017
9
Central Centrifugal Cicatricial Alopecia: New Insights and a Call for Action. ( 28941495 )
2017
10
A Probable Case of Central Centrifugal Cicatricial Alopecia Encountered in Mark Twain's Autobiography. ( 27532356 )
2016
11
Factors affecting the severity of central centrifugal cicatricial alopecia. ( 26769173 )
2016
12
Central centrifugal cicatricial alopecia: challenges and solutions. ( 27574457 )
2016
13
Central Centrifugal Cicatricial Alopecia in Children: A Case Series and Review of the Literature. ( 27981623 )
2016
14
Central Centrifugal Cicatricial Alopecia Presenting with Irregular Patchy Alopecia on the Lateral and Posterior Scalp. ( 27172374 )
2015
15
Pathologic diagnosis of central centrifugal cicatricial alopecia on horizontal sections. ( 25222198 )
2014
16
Hair transplantation in the surgical treatment of central centrifugal cicatricial alopecia. ( 25207763 )
2014
17
Central centrifugal cicatricial alopecia: what has been achieved, current clues for future research. ( 24680004 )
2014
18
Dermatoscopic features of central centrifugal cicatricial alopecia. ( 24929886 )
2014
19
Central centrifugal cicatricial alopecia. ( 23440368 )
2013
20
Central centrifugal cicatricial alopecia severity is associated with cowhage-induced itch. ( 22985403 )
2013
21
Differentiating central centrifugal cicatricial alopecia and androgenetic alopecia in african american men: report of three cases. ( 22768355 )
2012
22
Central centrifugal cicatricial alopecia: possible familial aetiology in two African families from South Africa. ( 23210944 )
2012
23
Traction: risk factor or coincidence in central centrifugal cicatricial alopecia? ( 22578250 )
2012
24
Hair breakage as a presenting sign of early or occult central centrifugal cicatricial alopecia: clinicopathologic findings in 9 patients. ( 22986858 )
2012
25
Primary follicular dystrophy with scarring dermatitis in C57BL/6 mouse substrains resembles central centrifugal cicatricial alopecia in humans. ( 20861494 )
2011
26
Cytokeratin 15 expression in central, centrifugal, cicatricial alopecia: new observations in normal and diseased hair follicles. ( 21251039 )
2011
27
Central centrifugal cicatricial alopecia - an approach to diagnosis and management. ( 22097988 )
2011
28
Prevalence and etiology of central centrifugal cicatricial alopecia. ( 21844458 )
2011
29
Prevalence of central centrifugal cicatricial alopecia. ( 22184774 )
2011
30
Medical and environmental risk factors for the development of central centrifugal cicatricial alopecia: a population study. ( 21482861 )
2011
31
Cytokeratin 75 expression in central, centrifugal, cicatricial alopecia--new observations in normal and diseased hair follicles. ( 19614992 )
2010
32
Central centrifugal cicatricial alopecia: retrospective chart review. ( 20868618 )
2010
33
Grooming and central centrifugal cicatricial alopecia. ( 20159316 )
2010
34
Hair grooming practices and central centrifugal cicatricial alopecia. ( 19293007 )
2009
35
Central centrifugal cicatricial alopecia: past, present, and future. ( 19293013 )
2009
36
Central centrifugal cicatricial alopecia: Superimposed tinea capitis as the etiology of chronic scalp pruritus. ( 19094841 )
2008
37
Central centrifugal cicatricial alopecia. ( 18715297 )
2008

Variations for Central Centrifugal Cicatricial Alopecia

ClinVar genetic disease variations for Central Centrifugal Cicatricial Alopecia:

6 (show all 12)
# Gene Variation Type Significance SNP ID Assembly Location
1 PADI3 NM_016233.2(PADI3): c.628C> T (p.Arg210Trp) single nucleotide variant Pathogenic rs139876092 GRCh38 Chromosome 1, 17267938: 17267938
2 PADI3 NM_016233.2(PADI3): c.628C> T (p.Arg210Trp) single nucleotide variant Pathogenic rs139876092 GRCh37 Chromosome 1, 17594433: 17594433
3 PADI3 NM_016233.2(PADI3): c.832-2A> G single nucleotide variant Pathogenic GRCh38 Chromosome 1, 17270877: 17270877
4 PADI3 NM_016233.2(PADI3): c.832-2A> G single nucleotide variant Pathogenic GRCh37 Chromosome 1, 17597372: 17597372
5 PADI3 NM_016233.2(PADI3): c.856A> G (p.Thr286Ala) single nucleotide variant Pathogenic rs139426141 GRCh38 Chromosome 1, 17270903: 17270903
6 PADI3 NM_016233.2(PADI3): c.856A> G (p.Thr286Ala) single nucleotide variant Pathogenic rs139426141 GRCh37 Chromosome 1, 17597398: 17597398
7 PADI3 NM_016233.2(PADI3): c.1669C> T (p.Arg557Trp) single nucleotide variant Pathogenic rs140482516 GRCh38 Chromosome 1, 17280704: 17280704
8 PADI3 NM_016233.2(PADI3): c.1669C> T (p.Arg557Trp) single nucleotide variant Pathogenic rs140482516 GRCh37 Chromosome 1, 17607199: 17607199
9 PADI3 NM_016233.2(PADI3): c.1744G> A (p.Ala582Thr) single nucleotide variant Pathogenic rs34097903 GRCh38 Chromosome 1, 17280779: 17280779
10 PADI3 NM_016233.2(PADI3): c.1744G> A (p.Ala582Thr) single nucleotide variant Pathogenic rs34097903 GRCh37 Chromosome 1, 17607274: 17607274
11 PADI3 NM_016233.2(PADI3): c.1955G> A (p.Arg652Lys) single nucleotide variant Pathogenic GRCh38 Chromosome 1, 17283039: 17283039
12 PADI3 NM_016233.2(PADI3): c.1955G> A (p.Arg652Lys) single nucleotide variant Pathogenic GRCh37 Chromosome 1, 17609534: 17609534

Expression for Central Centrifugal Cicatricial Alopecia

Search GEO for disease gene expression data for Central Centrifugal Cicatricial Alopecia.

Pathways for Central Centrifugal Cicatricial Alopecia

Pathways related to Central Centrifugal Cicatricial Alopecia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.08 KRT15 KRT75

GO Terms for Central Centrifugal Cicatricial Alopecia

Cellular components related to Central Centrifugal Cicatricial Alopecia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament GO:0005882 8.62 KRT15 KRT75

Biological processes related to Central Centrifugal Cicatricial Alopecia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 keratinization GO:0031424 8.96 KRT15 KRT75
2 cornification GO:0070268 8.62 KRT15 KRT75

Sources for Central Centrifugal Cicatricial Alopecia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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