Central Corneal Ulcer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CNT026 MIFTS: 22	Central Corneal Ulcer Categories: Eye diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Central Corneal Ulcer

MalaCards integrated aliases for Central Corneal Ulcer:

Name: Central Corneal Ulcer ¹² ¹⁵ ⁷¹

Classifications:

MalaCards categories:
Anatomical: Eye diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:9910

ICD9CM ³⁴ 370.03

SNOMED-CT ⁶⁷ 7426009

ICD10 ³² H16.01

UMLS ⁷¹ C0155069

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Summaries for Central Corneal Ulcer

Disease Ontology : ¹² A corneal ulcer that is characterized by ulceration and opacification of the central cornea and is caused by minor trauma and subsequent infection by bacterial or mycotic organisms.

MalaCards based summary : Central Corneal Ulcer is related to corneal ulcer and keratitis, hereditary. An important gene associated with Central Corneal Ulcer is CER1 (Cerberus 1, DAN Family BMP Antagonist), and among its related pathways/superpathways are Diseases of glycosylation and Microglia Activation During Neuroinflammation: Overview. Affiliated tissues include eye and t cells, and related phenotype is Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance.

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Related Diseases for Central Corneal Ulcer

Diseases in the Corneal Ulcer family:

Central Corneal Ulcer

Diseases related to Central Corneal Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 11)

#	Related Disease	Score	Top Affiliating Genes
1	corneal ulcer	10.2
2	keratitis, hereditary	10.0
3	gastrointestinal ulceration, recurrent, with dysfunctional platelets	10.0
4	lagophthalmos	9.9
5	keratopathy	9.9
6	endophthalmitis	9.9
7	haemophilus influenzae	9.9
8	climatic droplet keratopathy	9.9
9	anisometropia	9.9	SFTA3 CER1
10	cycloplegia	9.8	SFTA3 CER1
11	eye accommodation disease	9.6	SFTA3 CER1

Graphical network of the top 20 diseases related to Central Corneal Ulcer:

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Symptoms & Phenotypes for Central Corneal Ulcer

GenomeRNAi Phenotypes related to Central Corneal Ulcer according to GeneCards Suite gene sharing:

²⁶

#	Description	GenomeRNAi Source Accession	Score	Top Affiliating Genes
1	Decreased focal adhesion (FA) area, decreased FA length, decreased FA mean intensity, increased number of small and round FAs, increased FA abundance	GR00210-A	8.8	HSPG2 MAPKAPK3 PBK

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Drugs & Therapeutics for Central Corneal Ulcer

Search Clinical Trials , NIH Clinical Center for Central Corneal Ulcer

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Genetic Tests for Central Corneal Ulcer

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Anatomical Context for Central Corneal Ulcer

MalaCards organs/tissues related to Central Corneal Ulcer:

⁴⁰

Eye, T Cells

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Publications for Central Corneal Ulcer

Articles related to Central Corneal Ulcer:

(show all 31)

#	Title	Authors	PMID	Year
1	Long-Term Descemetocele Management With Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) Treatment. ⁶¹	Xu M...Chiu GB	30985491	2019
2	Contact lens-related visual loss in the context of microbial keratitis. ⁶¹	Mohammadpour M...Bazvand F	30858743	2019
3	Does PACK-CXL Change the Prognosis of Resistant Infectious Keratitis? ⁶¹	Zloto O...Avni-Zauberman N	30089187	2018
4	Conjunctival Hyperemia or Vasodilation and Central Corneal Ulcer in a Neonate. ⁶¹	Kroeger Z...Cavuoto KM	29494721	2018
5	Focal uterine T-cell lymphoma in an ovariectomized cat. ⁶¹	Conversy B...Graille M	29035655	2017
6	Intraocular minocycline for the treatment of ocular pythiosis. ⁶¹	Ros Castellar F...Boto de Los Bueis A	28546303	2017
7	Microsporidial Stromal Keratitis: Successful Treatment with Topical Voriconazole and Oral Itraconazole. ⁶¹	Coca M...Kapur M	28123915	2016
8	[Prolonged topical natamycin 5 % therapy before and after keratoplasty for Fusarium keratitis]. ⁶¹	Cvetkova N...Dietrich-Ntoukas T	26205744	2016
9	Elizabethkingia meningoseptica and Contact Lens Use. ⁶¹	Beato JN...Falcao-Reis F	27349783	2016
10	[Novel approach to treatment of lagophthalmos-associated neuroparalytic keratitis]. ⁶¹	Kasparov ??...Kasparova ??	26977724	2015
11	Pink hypopyon in a patient with Serratia marcescens corneal ulceration. ⁶¹	Stefater JA...Chodosh J	25861400	2015
12	Pseudomonas aeruginosa keratitis misdiagnosed as fungal keratitis by in vivo confocal microscopy: a case report. ⁶¹	Hong J...Xu J	25495791	2014
13	A Severe Case of Arthrographis kalrae Keratomycosis. ⁶¹	Ramli SR...Khaithir TM	24377053	2013
14	Fungal Keratitis Caused by Drechslera spp. Treated with Voriconazole: A Case Report. ⁶¹	Echavez MI...Carino NS	24151572	2013
15	Keratomycosis caused by Exserohilum rostratum. ⁶¹	Joseph NM...Kumar S	22771657	2012
16	Severe Arthrographis kalrae keratomycosis in an immunocompetent patient. ⁶¹	Thomas BC...Dithmar S	21045668	2011
17	Polymerase chain reaction in pediatric post-traumatic fungal endophthalmitis among Egyptian children. ⁶¹	Salman AG...Mansour LE	20370343	2010
18	[Treatment for central corneal ulcer in the presence of lagophthalmos by autoconjunctivoplasty in combination with optic iridectomy and external blepharorrhaphy a clinical case]. ⁶¹	Kasparov AA...Sobkova OI	21105377	2010
19	UV-A Collagen Cross-Linking Treatment of Bullous Keratopathy Combined With Corneal Ulcer. ⁶¹	Kozobolis V...Toufexis G	20023590	2010
20	Bovine pericardium in treating large corneal perforation secondary to alkali injury: a case report. ⁶¹	Khanna RK...Mokhtar E	18711278	2008
21	Bilateral simultaneous infectious keratitis secondary to contact lens wear: an unusual case report with rare organisms. ⁶¹	Ali NA...Reddy SC	17993833	2007
22	Toxic keratolysis from combined use of nonsteroid anti-inflammatory drugs and topical steroids following vitreoretinal surgery. ⁶¹	Alvarez MT...Teus MA	16952098	2006
23	Relapsing polychondritis: a rare disease with varying symptoms. ⁶¹	Peebo BB...Frennesson C	15291945	2004
24	Fungal keratitis after photorefractive keratectomy: delayed diagnosis and treatment in a co-managed setting. ⁶¹	Periman LM...Kim J	12777034	2003
25	[Unilateral trigeminal nerve hypoplasia]. ⁶¹	Ries MW...Volcker HE	9340409	1997
26	Haemophilus influenzae central corneal ulcer associated with cosmetic lens wear. ⁶¹	Leahey AB...Jones D	8828940	1996
27	Peripheral corneal infiltrates associated with contact lens wear. ⁶¹	Donshik PC...Ehlers WH	8719670	1995
28	[Central corneal ulcer after eye injury caused by a branch of a shrub]. ⁶¹		8089415	1994
29	[Acanthamoeba keratitis--a too seldom diagnosed disease?]. ⁶¹	Huber-Spitzy V...Haddad R	2761194	1989
30	Anaerobic streptococcal corneal ulcer. ⁶¹	Ostler HB...Okumoto M	1266933	1976
31	Recurrent keratitis due to Acremonium potronii. ⁶¹	Forster RK...Stiles W	234118	1975

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Genes for Central Corneal Ulcer

Genes related to Central Corneal Ulcer (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CER1	Cerberus 1, DAN Family BMP Antagonist	Protein Coding	6.1	DISEASES inferred ¹⁵
2	PBK	PDZ Binding Kinase	Protein Coding	5.64	DISEASES inferred ¹⁵
3	SFTA3	Surfactant Associated 3	RNA Gene	5.2	DISEASES inferred ¹⁵
4	HSPG2	Heparan Sulfate Proteoglycan 2	Protein Coding	4.9	DISEASES inferred ¹⁵
5	MAPKAPK3	MAPK Activated Protein Kinase 3	Protein Coding	4.85	DISEASES inferred ¹⁵
6	OXA1L	OXA1L Mitochondrial Inner Membrane Protein	Protein Coding	4.78	DISEASES inferred ¹⁵
7	GPC2	Glypican 2	Protein Coding	4.7	DISEASES inferred ¹⁵

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Variations for Central Corneal Ulcer

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Expression for Central Corneal Ulcer

Search GEO for disease gene expression data for Central Corneal Ulcer.

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Pathways for Central Corneal Ulcer

Pathways related to Central Corneal Ulcer according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Diseases of glycosylation ⁶⁵ Show member pathways Diseases associated with O-glycosylation of proteins ⁶⁵	11.12	HSPG2 GPC2
2	Microglia Activation During Neuroinflammation: Overview ⁶⁴ Show member pathways Microglia Activation During Neuroinflammation: Microglia Activation ⁶⁴	10.72	HSPG2 GPC2

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GO Terms for Central Corneal Ulcer

Cellular components related to Central Corneal Ulcer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	Golgi lumen	GO:0005796	8.96	HSPG2 GPC2
2	lysosomal lumen	GO:0043202	8.62	HSPG2 GPC2

Biological processes related to Central Corneal Ulcer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	retinoid metabolic process	GO:0001523	9.16	HSPG2 GPC2
2	glycosaminoglycan biosynthetic process	GO:0006024	8.96	HSPG2 GPC2
3	glycosaminoglycan catabolic process	GO:0006027	8.62	HSPG2 GPC2

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Sources for Central Corneal Ulcer

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

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⁹ Cosmic

¹⁰ dbSNP

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¹³ diseasecard

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¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

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³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

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⁴⁰ MalaCards

⁴¹ MedGen

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⁴³ MeSH

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⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

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⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NIH Rare Diseases

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM

⁵⁷ OMIM via Orphanet

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ TGDB

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ Wikipedia