MCID: CNT026
MIFTS: 22

Central Corneal Ulcer

Categories: Eye diseases, Neuronal diseases

Aliases & Classifications for Central Corneal Ulcer

MalaCards integrated aliases for Central Corneal Ulcer:

Name: Central Corneal Ulcer 12 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:9910
ICD9CM 34 370.03
SNOMED-CT 67 193761009
ICD10 32 H16.01
UMLS 70 C0155069

Summaries for Central Corneal Ulcer

Disease Ontology : 12 A corneal ulcer that is characterized by ulceration and opacification of the central cornea and is caused by minor trauma and subsequent infection by bacterial or mycotic organisms.

MalaCards based summary : Central Corneal Ulcer is related to gastrointestinal ulceration, recurrent, with dysfunctional platelets and corneal ulcer. An important gene associated with Central Corneal Ulcer is SFTA3 (Surfactant Associated 3), and among its related pathways/superpathways are HIV Life Cycle and Glycosaminoglycan metabolism. Affiliated tissues include eye.

Related Diseases for Central Corneal Ulcer

Diseases in the Corneal Ulcer family:

Central Corneal Ulcer

Diseases related to Central Corneal Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 gastrointestinal ulceration, recurrent, with dysfunctional platelets 10.2
2 corneal ulcer 10.2
3 keratitis, hereditary 10.1
4 lagophthalmos 9.9
5 endophthalmitis 9.9
6 haemophilus influenzae 9.9
7 omodysplasia 9.7 GPC4 GPC2
8 tumoral calcinosis, hyperphosphatemic, familial, 1 9.6 GPC4 GPC2
9 hypotrichosis 2 9.5 HSPG2 GPC4 GPC2

Graphical network of the top 20 diseases related to Central Corneal Ulcer:



Diseases related to Central Corneal Ulcer

Symptoms & Phenotypes for Central Corneal Ulcer

Drugs & Therapeutics for Central Corneal Ulcer

Search Clinical Trials , NIH Clinical Center for Central Corneal Ulcer

Genetic Tests for Central Corneal Ulcer

Anatomical Context for Central Corneal Ulcer

MalaCards organs/tissues related to Central Corneal Ulcer:

40
Eye

Publications for Central Corneal Ulcer

Articles related to Central Corneal Ulcer:

(show all 32)
# Title Authors PMID Year
1
Navigating a Curious Case of Unilateral Keratouveitis in Pakistan. 61
33585119 2021
2
Long-Term Descemetocele Management With Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) Treatment. 61
30985491 2020
3
Contact lens-related visual loss in the context of microbial keratitis. 61
30858743 2019
4
Does PACK-CXL Change the Prognosis of Resistant Infectious Keratitis? 61
30089187 2018
5
Conjunctival Hyperemia or Vasodilation and Central Corneal Ulcer in a Neonate. 61
29494721 2018
6
Focal uterine T-cell lymphoma in an ovariectomized cat. 61
29035655 2017
7
Intraocular minocycline for the treatment of ocular pythiosis. 61
28546303 2017
8
Microsporidial Stromal Keratitis: Successful Treatment with Topical Voriconazole and Oral Itraconazole. 61
28123915 2016
9
[Prolonged topical natamycin 5‚ÄČ% therapy before and after keratoplasty for Fusarium keratitis]. 61
26205744 2016
10
Elizabethkingia meningoseptica and Contact Lens Use. 61
27349783 2016
11
[Novel approach to treatment of lagophthalmos-associated neuroparalytic keratitis]. 61
26977724 2015
12
Pink hypopyon in a patient with Serratia marcescens corneal ulceration. 61
25861400 2015
13
Pseudomonas aeruginosa keratitis misdiagnosed as fungal keratitis by in vivo confocal microscopy: a case report. 61
25495791 2014
14
Fungal Keratitis Caused by Drechslera spp. Treated with Voriconazole: A Case Report. 61
24151572 2013
15
A Severe Case of Arthrographis kalrae Keratomycosis. 61
24377053 2013
16
Keratomycosis caused by Exserohilum rostratum. 61
22771657 2012
17
Severe Arthrographis kalrae keratomycosis in an immunocompetent patient. 61
21045668 2011
18
Polymerase chain reaction in pediatric post-traumatic fungal endophthalmitis among Egyptian children. 61
20370343 2010
19
[Treatment for central corneal ulcer in the presence of lagophthalmos by autoconjunctivoplasty in combination with optic iridectomy and external blepharorrhaphy a clinical case]. 61
21105377 2010
20
UV-A Collagen Cross-Linking Treatment of Bullous Keratopathy Combined With Corneal Ulcer. 61
20023590 2010
21
Bovine pericardium in treating large corneal perforation secondary to alkali injury: a case report. 61
18711278 2008
22
Bilateral simultaneous infectious keratitis secondary to contact lens wear: an unusual case report with rare organisms. 61
17993833 2007
23
Toxic keratolysis from combined use of nonsteroid anti-inflammatory drugs and topical steroids following vitreoretinal surgery. 61
16952098 2006
24
Relapsing polychondritis: a rare disease with varying symptoms. 61
15291945 2004
25
Fungal keratitis after photorefractive keratectomy: delayed diagnosis and treatment in a co-managed setting. 61
12777034 2003
26
[Unilateral trigeminal nerve hypoplasia]. 61
9340409 1997
27
Haemophilus influenzae central corneal ulcer associated with cosmetic lens wear. 61
8828940 1996
28
Peripheral corneal infiltrates associated with contact lens wear. 61
8719670 1995
29
[Central corneal ulcer after eye injury caused by a branch of a shrub]. 61
8089415 1994
30
[Acanthamoeba keratitis--a too seldom diagnosed disease?]. 61
2761194 1989
31
Anaerobic streptococcal corneal ulcer. 61
1266933 1976
32
Recurrent keratitis due to Acremonium potronii. 61
234118 1975

Variations for Central Corneal Ulcer

Expression for Central Corneal Ulcer

Search GEO for disease gene expression data for Central Corneal Ulcer.

Pathways for Central Corneal Ulcer

Pathways related to Central Corneal Ulcer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.04 SFTA3 HSPG2 GPC4 GPC2
2
Show member pathways
12.25 HSPG2 GPC4 GPC2
3
Show member pathways
12.04 HSPG2 GPC4 GPC2
4
Show member pathways
11.84 HSPG2 GPC4 GPC2
5
Show member pathways
11.46 HSPG2 GPC4 GPC2
6
Show member pathways
10.96 HSPG2 GPC4 GPC2

GO Terms for Central Corneal Ulcer

Cellular components related to Central Corneal Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.72 SRGN SFTA3 HSPG2 GPC4 GPC2
2 extracellular space GO:0005615 9.55 SRGN SFTA3 HSPG2 GPC4 GPC2
3 collagen-containing extracellular matrix GO:0062023 9.54 HSPG2 GPC4 GPC2
4 anchored component of membrane GO:0031225 9.4 GPC4 GPC2
5 anchored component of plasma membrane GO:0046658 9.26 GPC4 GPC2
6 Golgi lumen GO:0005796 9.13 HSPG2 GPC4 GPC2
7 lysosomal lumen GO:0043202 8.8 HSPG2 GPC4 GPC2

Biological processes related to Central Corneal Ulcer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 retinoid metabolic process GO:0001523 9.33 HSPG2 GPC4 GPC2
2 regulation of signal transduction GO:0009966 9.32 GPC4 GPC2
3 regulation of protein localization to membrane GO:1905475 9.26 GPC4 GPC2
4 glycosaminoglycan biosynthetic process GO:0006024 9.13 HSPG2 GPC4 GPC2
5 glycosaminoglycan catabolic process GO:0006027 8.8 HSPG2 GPC4 GPC2

Sources for Central Corneal Ulcer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....