Central Corneal Ulcer disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CNT026 MIFTS: 22	Central Corneal Ulcer Categories: Eye diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Expand all tables

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Aliases & Classifications for Central Corneal Ulcer

MalaCards integrated aliases for Central Corneal Ulcer:

Name: Central Corneal Ulcer ¹² ¹⁵ ⁷⁰

Classifications:

MalaCards categories:
Anatomical: Neuronal diseases Eye diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:9910

ICD9CM ³⁴ 370.03

SNOMED-CT ⁶⁷ 193761009

ICD10 ³² H16.01

UMLS ⁷⁰ C0155069

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Summaries for Central Corneal Ulcer

Disease Ontology : ¹² A corneal ulcer that is characterized by ulceration and opacification of the central cornea and is caused by minor trauma and subsequent infection by bacterial or mycotic organisms.

MalaCards based summary : Central Corneal Ulcer is related to gastrointestinal ulceration, recurrent, with dysfunctional platelets and corneal ulcer. An important gene associated with Central Corneal Ulcer is SFTA3 (Surfactant Associated 3), and among its related pathways/superpathways are HIV Life Cycle and Glycosaminoglycan metabolism. Affiliated tissues include eye.

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Related Diseases for Central Corneal Ulcer

Diseases in the Corneal Ulcer family:

Central Corneal Ulcer

Diseases related to Central Corneal Ulcer via text searches within MalaCards or GeneCards Suite gene sharing:

#	Related Disease	Score	Top Affiliating Genes
1	gastrointestinal ulceration, recurrent, with dysfunctional platelets	10.2
2	corneal ulcer	10.2
3	keratitis, hereditary	10.1
4	lagophthalmos	9.9
5	endophthalmitis	9.9
6	haemophilus influenzae	9.9
7	omodysplasia	9.7	GPC4 GPC2
8	tumoral calcinosis, hyperphosphatemic, familial, 1	9.6	GPC4 GPC2
9	hypotrichosis 2	9.5	HSPG2 GPC4 GPC2

Graphical network of the top 20 diseases related to Central Corneal Ulcer:

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Symptoms & Phenotypes for Central Corneal Ulcer

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Drugs & Therapeutics for Central Corneal Ulcer

Search Clinical Trials , NIH Clinical Center for Central Corneal Ulcer

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Genetic Tests for Central Corneal Ulcer

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Anatomical Context for Central Corneal Ulcer

MalaCards organs/tissues related to Central Corneal Ulcer:

⁴⁰

Eye

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Publications for Central Corneal Ulcer

Articles related to Central Corneal Ulcer:

(show all 32)

#	Title	Authors	PMID	Year
1	Navigating a Curious Case of Unilateral Keratouveitis in Pakistan. ⁶¹	Karam A...Khan BS	33585119	2021
2	Long-Term Descemetocele Management With Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) Treatment. ⁶¹	Xu M...Chiu GB	30985491	2020
3	Contact lens-related visual loss in the context of microbial keratitis. ⁶¹	Mohammadpour M...Bazvand F	30858743	2019
4	Does PACK-CXL Change the Prognosis of Resistant Infectious Keratitis? ⁶¹	Zloto O...Avni-Zauberman N	30089187	2018
5	Conjunctival Hyperemia or Vasodilation and Central Corneal Ulcer in a Neonate. ⁶¹	Kroeger Z...Cavuoto KM	29494721	2018
6	Focal uterine T-cell lymphoma in an ovariectomized cat. ⁶¹	Conversy B...Graille M	29035655	2017
7	Intraocular minocycline for the treatment of ocular pythiosis. ⁶¹	Ros Castellar F...Boto de Los Bueis A	28546303	2017
8	Microsporidial Stromal Keratitis: Successful Treatment with Topical Voriconazole and Oral Itraconazole. ⁶¹	Coca M...Kapur M	28123915	2016
9	[Prolonged topical natamycin 5 % therapy before and after keratoplasty for Fusarium keratitis]. ⁶¹	Cvetkova N...Dietrich-Ntoukas T	26205744	2016
10	Elizabethkingia meningoseptica and Contact Lens Use. ⁶¹	Beato JN...Falcao-Reis F	27349783	2016
11	[Novel approach to treatment of lagophthalmos-associated neuroparalytic keratitis]. ⁶¹	Kasparov ??...Kasparova ??	26977724	2015
12	Pink hypopyon in a patient with Serratia marcescens corneal ulceration. ⁶¹	Stefater JA...Chodosh J	25861400	2015
13	Pseudomonas aeruginosa keratitis misdiagnosed as fungal keratitis by in vivo confocal microscopy: a case report. ⁶¹	Hong J...Xu J	25495791	2014
14	Fungal Keratitis Caused by Drechslera spp. Treated with Voriconazole: A Case Report. ⁶¹	Echavez MI...Carino NS	24151572	2013
15	A Severe Case of Arthrographis kalrae Keratomycosis. ⁶¹	Ramli SR...Khaithir TM	24377053	2013
16	Keratomycosis caused by Exserohilum rostratum. ⁶¹	Joseph NM...Kumar S	22771657	2012
17	Severe Arthrographis kalrae keratomycosis in an immunocompetent patient. ⁶¹	Thomas BC...Dithmar S	21045668	2011
18	Polymerase chain reaction in pediatric post-traumatic fungal endophthalmitis among Egyptian children. ⁶¹	Salman AG...Mansour LE	20370343	2010
19	[Treatment for central corneal ulcer in the presence of lagophthalmos by autoconjunctivoplasty in combination with optic iridectomy and external blepharorrhaphy a clinical case]. ⁶¹	Kasparov AA...Sobkova OI	21105377	2010
20	UV-A Collagen Cross-Linking Treatment of Bullous Keratopathy Combined With Corneal Ulcer. ⁶¹	Kozobolis V...Toufexis G	20023590	2010
21	Bovine pericardium in treating large corneal perforation secondary to alkali injury: a case report. ⁶¹	Khanna RK...Mokhtar E	18711278	2008
22	Bilateral simultaneous infectious keratitis secondary to contact lens wear: an unusual case report with rare organisms. ⁶¹	Ali NA...Reddy SC	17993833	2007
23	Toxic keratolysis from combined use of nonsteroid anti-inflammatory drugs and topical steroids following vitreoretinal surgery. ⁶¹	Alvarez MT...Teus MA	16952098	2006
24	Relapsing polychondritis: a rare disease with varying symptoms. ⁶¹	Peebo BB...Frennesson C	15291945	2004
25	Fungal keratitis after photorefractive keratectomy: delayed diagnosis and treatment in a co-managed setting. ⁶¹	Periman LM...Kim J	12777034	2003
26	[Unilateral trigeminal nerve hypoplasia]. ⁶¹	Ries MW...Volcker HE	9340409	1997
27	Haemophilus influenzae central corneal ulcer associated with cosmetic lens wear. ⁶¹	Leahey AB...Jones D	8828940	1996
28	Peripheral corneal infiltrates associated with contact lens wear. ⁶¹	Donshik PC...Ehlers WH	8719670	1995
29	[Central corneal ulcer after eye injury caused by a branch of a shrub]. ⁶¹		8089415	1994
30	[Acanthamoeba keratitis--a too seldom diagnosed disease?]. ⁶¹	Huber-Spitzy V...Haddad R	2761194	1989
31	Anaerobic streptococcal corneal ulcer. ⁶¹	Ostler HB...Okumoto M	1266933	1976
32	Recurrent keratitis due to Acremonium potronii. ⁶¹	Forster RK...Stiles W	234118	1975

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Genes for Central Corneal Ulcer

Genes related to Central Corneal Ulcer (0 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	SFTA3	Surfactant Associated 3	RNA Gene	5.4	DISEASES inferred ¹⁵
2	HSPG2	Heparan Sulfate Proteoglycan 2	Protein Coding	5.27	DISEASES inferred ¹⁵
3	OXA1L	OXA1L Mitochondrial Inner Membrane Protein	Protein Coding	5.14	DISEASES inferred ¹⁵
4	GPC2	Glypican 2	Protein Coding	4.71	DISEASES inferred ¹⁵
5	SRGN	Serglycin	Protein Coding	4.6	DISEASES inferred ¹⁵
6	GPC4	Glypican 4	Protein Coding	4.57	DISEASES inferred ¹⁵

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Variations for Central Corneal Ulcer

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Expression for Central Corneal Ulcer

Search GEO for disease gene expression data for Central Corneal Ulcer.

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Pathways for Central Corneal Ulcer

Pathways related to Central Corneal Ulcer according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	HIV Life Cycle ⁶⁵ Show member pathways 2-LTR circle formation ⁶⁵ APOBEC3G mediated resistance to HIV-1 infection ⁶⁵ Assembly Of The HIV Virion ⁶⁵ Binding and entry of HIV virion ⁶⁵ Disease ⁶⁵ Diseases of signal transduction ⁶⁵ Early Phase of HIV Life Cycle ⁶⁵ HIV Infection ⁶⁵ Host Interactions of HIV factors ⁶⁵ Infectious disease ⁶⁵ Integration of provirus ⁶⁵ Late Phase of HIV Life Cycle ⁶⁵	13.04	SFTA3 HSPG2 GPC4 GPC2
2	Glycosaminoglycan metabolism ⁶⁵ Show member pathways chondroitin sulfate biosynthesis ¹ chondroitin sulfate biosynthesis (late stages) ¹ Heparan sulfate/heparin (HS-GAG) metabolism ⁶⁵ HS-GAG biosynthesis ⁶⁵ Hyaluronan biosynthesis and export ⁶⁵ Hyaluronan metabolism ⁶⁵ Hyaluronan uptake and degradation ⁶⁵ Metabolism of carbohydrates ⁶⁵	12.25	HSPG2 GPC4 GPC2
3	Metabolism of water-soluble vitamins and cofactors ⁶⁵ Show member pathways [2Fe-2S] iron-sulfur cluster biosynthesis ¹ Biotin transport and metabolism ⁶⁵ biotin-carboxyl carrier protein assembly ¹ coenzyme A biosynthesis ¹ Coenzyme A biosynthesis ⁶⁵ flavin biosynthesis ¹ folate polyglutamylation ¹ glycine/serine biosynthesis ¹ Metabolism of folate and pterines ⁶⁵ Metabolism of vitamins and cofactors ⁶⁵ molybdenum cofactor biosynthesis ¹ Molybdenum cofactor biosynthesis ⁶⁵ thiamin salvage III ¹ thio-molybdenum cofactor biosynthesis ¹ Vitamin B1 (thiamin) metabolism ⁶⁵ Vitamin B2 (riboflavin) metabolism ⁶⁵ Vitamin B5 (pantothenate) metabolism ⁶⁵ Vitamin C (ascorbate) metabolism ⁶⁵ Vitamins B6 activation to pyridoxal phosphate ⁶⁵	12.04	HSPG2 GPC4 GPC2
4	Chondroitin sulfate/dermatan sulfate metabolism ⁶⁵ Show member pathways A tetrasaccharide linker sequence is required for GAG synthesis ⁶⁵ chondroitin biosynthesis ¹ Chondroitin sulfate biosynthesis ⁶⁵ CS/DS degradation ⁶⁵ Defective B3GALT6 causes EDSP2 and SEMDJL1 ⁶⁵ Defective B3GAT3 causes JDSSDHD ⁶⁵ Defective B4GALT7 causes EDS, progeroid type ⁶⁵ Defective CHST14 causes EDS, musculocontractural type ⁶⁵ Defective CHST3 causes SEDCJD ⁶⁵ Defective CHSY1 causes TPBS ⁶⁵ Defective EXT1 causes exostoses 1, TRPS2 and CHDS ⁶⁵ Defective EXT2 causes exostoses 2 ⁶⁵ dermatan sulfate biosynthesis ¹ Dermatan sulfate biosynthesis ⁶⁵ dermatan sulfate biosynthesis (late stages) ¹ Diseases associated with glycosaminoglycan metabolism ⁶⁵ glycoaminoglycan-protein linkage region biosynthesis ¹ Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate ³⁶ Glypican pathway ¹ HS-GAG degradation ⁶⁵ Proteogylcan syndecan-mediated signaling events ¹	11.84	HSPG2 GPC4 GPC2
5	Metabolism of fat-soluble vitamins ⁶⁵ Show member pathways Metabolism of vitamin K ⁶⁵ Retinoid metabolism and transport ⁶⁵ The retinoid cycle in cones (daylight vision) ⁶⁵ Visual phototransduction ⁶⁵ Vitamin D (calciferol) metabolism ⁶⁵	11.46	HSPG2 GPC4 GPC2
6	Diseases of glycosylation ⁶⁵ Show member pathways Diseases associated with O-glycosylation of proteins ⁶⁵	10.96	HSPG2 GPC4 GPC2

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GO Terms for Central Corneal Ulcer

Cellular components related to Central Corneal Ulcer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	extracellular region	GO:0005576	9.72	SRGN SFTA3 HSPG2 GPC4 GPC2
2	extracellular space	GO:0005615	9.55	SRGN SFTA3 HSPG2 GPC4 GPC2
3	collagen-containing extracellular matrix	GO:0062023	9.54	HSPG2 GPC4 GPC2
4	anchored component of membrane	GO:0031225	9.4	GPC4 GPC2
5	anchored component of plasma membrane	GO:0046658	9.26	GPC4 GPC2
6	Golgi lumen	GO:0005796	9.13	HSPG2 GPC4 GPC2
7	lysosomal lumen	GO:0043202	8.8	HSPG2 GPC4 GPC2

Biological processes related to Central Corneal Ulcer according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	retinoid metabolic process	GO:0001523	9.33	HSPG2 GPC4 GPC2
2	regulation of signal transduction	GO:0009966	9.32	GPC4 GPC2
3	regulation of protein localization to membrane	GO:1905475	9.26	GPC4 GPC2
4	glycosaminoglycan biosynthetic process	GO:0006024	9.13	HSPG2 GPC4 GPC2
5	glycosaminoglycan catabolic process	GO:0006027	8.8	HSPG2 GPC4 GPC2

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Sources for Central Corneal Ulcer

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia