MCID: CNT032
MIFTS: 17

Central Nervous System Adult Germ Cell Tumor

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Adult Germ Cell Tumor

MalaCards integrated aliases for Central Nervous System Adult Germ Cell Tumor:

Name: Central Nervous System Adult Germ Cell Tumor 12
Germ Cell Tumor of the Adult Cns 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5349
NCIt 51 C6285
UMLS 74 C0280796

Summaries for Central Nervous System Adult Germ Cell Tumor

MalaCards based summary : Central Nervous System Adult Germ Cell Tumor, also known as germ cell tumor of the adult cns, is related to adult central nervous system embryonal carcinoma and adult central nervous system mixed germ cell tumor. The drugs Carboplatin and Ifosfamide have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and bone marrow.

Related Diseases for Central Nervous System Adult Germ Cell Tumor

Diseases in the Central Nervous System Germ Cell Tumor family:

Central Nervous System Adult Germ Cell Tumor

Diseases related to Central Nervous System Adult Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 adult central nervous system embryonal carcinoma 11.4
2 adult central nervous system mixed germ cell tumor 11.4

Symptoms & Phenotypes for Central Nervous System Adult Germ Cell Tumor

Drugs & Therapeutics for Central Nervous System Adult Germ Cell Tumor

Drugs for Central Nervous System Adult Germ Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 140)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 38904 498142
2
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
3
Etoposide Approved Phase 3,Phase 2 33419-42-0 36462
4
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 2767 441203 84093
5
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
6
Donepezil Approved Phase 3,Phase 2 120014-06-4 3152
7
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
8
Ofloxacin Approved Phase 3 82419-36-1 4583
9 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
10 Alkylating Agents Phase 3,Phase 2,Phase 1
11
Isophosphamide mustard Phase 3,Phase 2,Phase 1 0
12 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
13 Etoposide phosphate Phase 3,Phase 2
14 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
15 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1,Not Applicable
16 Peripheral Nervous System Agents Phase 3,Phase 2
17 Anti-Infective Agents Phase 3,Phase 1,Phase 2
18 Narcotics Phase 3
19 Adjuvants, Anesthesia Phase 3
20 Analgesics Phase 3
21 Anesthetics, Intravenous Phase 3
22 Liver Extracts Phase 3,Phase 1
23 Anesthetics, General Phase 3
24 Anesthetics Phase 3
25 Analgesics, Opioid Phase 3
26 Central Nervous System Depressants Phase 3
27 Cola Phase 3,Phase 1
28 Cholinesterase Inhibitors Phase 3,Phase 2
29 Neurotransmitter Agents Phase 3,Phase 2
30 Nootropic Agents Phase 3,Phase 2
31 Cholinergic Agents Phase 3,Phase 2
32 Anti-Infective Agents, Urinary Phase 3
33 Cytochrome P-450 Enzyme Inhibitors Phase 3
34 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
35 Anti-Bacterial Agents Phase 3,Phase 1,Phase 2
36 Renal Agents Phase 3
37
Lenograstim Approved, Investigational Phase 2,Phase 1 135968-09-1
38
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
39
Thiotepa Approved, Investigational Phase 2,Phase 1 52-24-4 5453
40
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2,Phase 1 1177-87-3
41
Dexamethasone Approved, Investigational, Vet_approved Phase 2,Phase 1 50-02-2 5743
42
Magnesium Sulfate Approved, Investigational, Vet_approved Phase 1, Phase 2 7487-88-9 24083
43
Mannitol Approved, Investigational Phase 1, Phase 2,Phase 2 69-65-8 6251 453
44
Mechlorethamine Approved, Investigational Phase 1, Phase 2,Phase 2 51-75-2 4033
45
Ranitidine Approved Phase 1, Phase 2 66357-59-3, 66357-35-5 3001055
46
Paclitaxel Approved, Vet_approved Phase 1, Phase 2,Phase 2,Not Applicable 33069-62-4 36314
47
Mesna Approved, Investigational Phase 1, Phase 2,Phase 2 3375-50-6 598
48
Gemcitabine Approved Phase 1, Phase 2 95058-81-4 60750
49
Furosemide Approved, Vet_approved Phase 1, Phase 2 54-31-9 3440
50
Bevacizumab Approved, Investigational Phase 2 216974-75-3

Interventional clinical trials:

(show all 41)
# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy and Radiation Therapy in Treating Patients With Germ Cell Tumors in the Brain Completed NCT00293358 Phase 3 carboplatin;cisplatin;etoposide phosphate;ifosfamide
2 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
3 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
4 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3 levofloxacin
5 Chemotherapy, Surgery, Radiation Therapy and Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Primary CNS Germ Cell Tumors Unknown status NCT00025324 Phase 2 carboplatin;cyclophosphamide;etoposide;thiotepa
6 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
7 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
8 Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer Completed NCT00492089 Phase 2 bevacizumab;placebo
9 Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor Completed NCT00070161 Phase 2 donepezil hydrochloride
10 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
11 Cisplatin and Etoposide Prior to Radiation Therapy in Treating Patients With CNS Tumors Completed NCT00002472 Phase 2 cisplatin;etoposide
12 Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
13 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
14 Chemotherapy and Vaccine Therapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation and Interleukin-2 in Treating Patients With Recurrent or Refractory Brain Cancer Completed NCT00014573 Phase 2 carmustine;cisplatin;cyclophosphamide;paclitaxel
15 High-dose ICE With Amifostine Completed NCT00003657 Phase 2 Amifostine;Carboplatin;Etoposide;Ifosfamide
16 Chemotherapy Plus Peripheral Stem Cell Transplant in Treating Patients With Central Nervous System Cancer Completed NCT00007982 Phase 2 carmustine;cisplatin;cyclophosphamide;etoposide;thiotepa
17 High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors Completed NCT00003173 Phase 2 thiotepa
18 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Tumors Completed NCT00003461 Phase 1, Phase 2
19 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
20 PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER Recruiting NCT01037790 Phase 2 PD-0332991
21 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
22 Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors Suspended NCT00983398 Phase 1, Phase 2 Carboplatin;Mannitol;Melphalan;Sodium Thiosulfate
23 Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors Terminated NCT01808534 Phase 2 palifosfamide
24 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
25 Stereotactic Radiosurgery in Treating Patients With Brain Tumors Completed NCT00019578 Phase 1
26 Bortezomib and Temozolomide in Treating Patients With Brain Tumors or Other Solid Tumors That Have Not Responded to Treatment Completed NCT00544284 Phase 1 bortezomib;temozolomide
27 Lapatinib and Paclitaxel in Treating Patients With Advanced Solid Tumors Completed NCT00313599 Phase 1 lapatinib;paclitaxel
28 Yttrium Y 90 SMT 487 in Treating Patients With Refractory or Recurrent Cancer Completed NCT00006368 Phase 1
29 Thalidomide and Docetaxel in Treating Patients With Advanced Cancer Completed NCT00049296 Phase 1 docetaxel;thalidomide
30 Calcitriol Plus Carboplatin in Treating Patients With Advanced Solid Tumors Completed NCT00008086 Phase 1 carboplatin
31 Radiolabeled Monoclonal Antibody Therapy After Radiation Therapy in Treating Patients With Primary Brain Tumors Completed NCT00003484 Phase 1 carmustine;irinotecan hydrochloride
32 Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation or Bone Marrow Transplantation in Treating Patients With Brain Cancer Completed NCT00025558 Phase 1 carboplatin;temozolomide;thiotepa
33 MS-275 in Treating Patients With Advanced Solid Tumors or Lymphoma Completed NCT00020579 Phase 1 entinostat
34 Carboxyamidotriazole and Paclitaxel in Treating Patients With Advanced Solid Tumors or Refractory Lymphomas Completed NCT00019019 Phase 1 carboxyamidotriazole;paclitaxel
35 Busulfan, Melphalan, Topotecan Hydrochloride, and a Stem Cell Transplant in Treating Patients With Newly Diagnosed or Relapsed Solid Tumor Active, not recruiting NCT00638898 Phase 1 busulfan;melphalan;topotecan hydrochloride
36 Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of Patients Who Are Undergoing Surgery or Biopsy for Newly Diagnosed Brain Tumors Terminated NCT00110032 Phase 1 EF5
37 Melphalan With BBBD in Treating Patients With Brain Malignancies Terminated NCT00253721 Phase 1 Melphalan
38 Changes in Semen or Sperm Caused by Temozolomide in Patients With Newly Diagnosed, Progressive, or Recurrent Primary Malignant Brain Tumors Completed NCT00499798
39 Acute Side Effects in Patients Who Are Undergoing Stereotactic Radiosurgery for Brain Tumors or Other Brain Disorders Completed NCT00255671
40 Paclitaxel Albumin-Stabilized Nanoparticle Formulation in Treating Patients With Advanced or Refractory Solid Tumors Withdrawn NCT00499291 Not Applicable paclitaxel albumin-stabilized nanoparticle formulation
41 Perfusion Magnetic Resonance Imaging in Measuring the Growth of Blood Vessels in Newly Diagnosed Brain Tumors Withdrawn NCT00005790 Not Applicable

Search NIH Clinical Center for Central Nervous System Adult Germ Cell Tumor

Genetic Tests for Central Nervous System Adult Germ Cell Tumor

Anatomical Context for Central Nervous System Adult Germ Cell Tumor

MalaCards organs/tissues related to Central Nervous System Adult Germ Cell Tumor:

42
Brain, Bone, Bone Marrow, Liver

Publications for Central Nervous System Adult Germ Cell Tumor

Variations for Central Nervous System Adult Germ Cell Tumor

Expression for Central Nervous System Adult Germ Cell Tumor

Search GEO for disease gene expression data for Central Nervous System Adult Germ Cell Tumor.

Pathways for Central Nervous System Adult Germ Cell Tumor

GO Terms for Central Nervous System Adult Germ Cell Tumor

Sources for Central Nervous System Adult Germ Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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