MCID: CNT002
MIFTS: 23

Central Nervous System Angiosarcoma

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Angiosarcoma

MalaCards integrated aliases for Central Nervous System Angiosarcoma:

Name: Central Nervous System Angiosarcoma 12 15 71
Hemangiosarcoma of the Cns 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4504
NCIt 49 C5450
UMLS 71 C1332875

Summaries for Central Nervous System Angiosarcoma

Disease Ontology : 12 A central nervous system sarcoma that is located in the inner lining of blood vessels.

MalaCards based summary : Central Nervous System Angiosarcoma, also known as hemangiosarcoma of the cns, is related to angiosarcoma and vulvar sarcoma. An important gene associated with Central Nervous System Angiosarcoma is SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1), and among its related pathways/superpathways is Cell adhesion molecules (CAMs). Affiliated tissues include inner lining of blood vessels, heart and bone, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Central Nervous System Angiosarcoma

Diseases related to Central Nervous System Angiosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 96)
# Related Disease Score Top Affiliating Genes
1 angiosarcoma 30.1 PECAM1 CD34
2 vulvar sarcoma 10.0 SMARCB1 CD34
3 retroperitoneal leiomyosarcoma 10.0 SMARCB1 CD34
4 hemosiderosis 10.0
5 exophthalmos 10.0
6 47,xyy 10.0
7 melanotic neurilemmoma 10.0 SMARCB1 CD34
8 neurilemmoma 10.0 SMARCB1 CD34
9 epithelioid malignant peripheral nerve sheath tumor 10.0 SMARCB1 CD34
10 malignant peripheral nerve sheath tumor 10.0 SMARCB1 CD34
11 retroperitoneal sarcoma 10.0 SMARCB1 CD34
12 central epithelioid sarcoma 9.9 SMARCB1 CD34
13 vulvar proximal-type epithelioid sarcoma 9.9 SMARCB1 CD34
14 extraosseous chondrosarcoma 9.9 SMARCB1 CD34
15 clear cell meningioma 9.9 SMARCB1 CD34
16 sweat gland neoplasm 9.9 SMARCB1 CD34
17 skin epithelioid hemangioma 9.9 PECAM1 CD34
18 hemangioma 9.9 PECAM1 CD34
19 prostate angiosarcoma 9.9 PECAM1 CD34
20 synovium cancer 9.9 SMARCB1 CD34
21 intravascular angioleiomyoma 9.9 PECAM1 CD34
22 heart fibrosarcoma 9.9 PECAM1 CD34
23 central nervous system hemangioma 9.9 PECAM1 CD34
24 ovarian angiosarcoma 9.9 PECAM1 CD34
25 conventional angiosarcoma 9.9 PECAM1 CD34
26 angiomyoma 9.9 PECAM1 CD34
27 aortic malignant tumor 9.9 PECAM1 CD34
28 gallbladder leiomyosarcoma 9.9 PECAM1 CD34
29 pediatric angiosarcoma 9.8 PECAM1 CD34
30 hemangioma of spleen 9.8 PECAM1 CD34
31 ovary sarcoma 9.8 PECAM1 CD34
32 heart leiomyosarcoma 9.8 PECAM1 CD34
33 colonic lymphangioma 9.8 PECAM1 CD34
34 lymphangioma 9.8 PECAM1 CD34
35 chondrosarcoma, extraskeletal myxoid 9.8 SMARCB1 CD34
36 benign perivascular tumor 9.8 PECAM1 CD34
37 liposarcoma of bone 9.8 PECAM1 CD34
38 kaposiform hemangioendothelioma 9.8 PECAM1 CD34
39 intravascular fasciitis 9.8 PECAM1 CD34
40 retroperitoneal hemangiopericytoma 9.8 PECAM1 CD34
41 erythema elevatum diutinum 9.8 PECAM1 CD34
42 liver leiomyoma 9.8 PECAM1 CD34
43 spleen cancer 9.8 PECAM1 CD34
44 hobnail hemangioma 9.8 PECAM1 CD34
45 breast hemangioma 9.8 PECAM1 CD34
46 breast angiosarcoma 9.8 PECAM1 CD34
47 lymphangiosarcoma 9.8 PECAM1 CD34
48 heart sarcoma 9.8 PECAM1 CD34
49 vulvar leiomyoma 9.8 PECAM1 CD34
50 glomeruloid hemangioma 9.8 PECAM1 CD34

Graphical network of the top 20 diseases related to Central Nervous System Angiosarcoma:



Diseases related to Central Nervous System Angiosarcoma

Symptoms & Phenotypes for Central Nervous System Angiosarcoma

GenomeRNAi Phenotypes related to Central Nervous System Angiosarcoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-1 9.17 PECAM1
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-11 9.17 SMARCB1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-14 9.17 PECAM1
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.17 SMARCB1
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-75 9.17 PECAM1 SMARCB1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-91 9.17 PECAM1

Drugs & Therapeutics for Central Nervous System Angiosarcoma

Search Clinical Trials , NIH Clinical Center for Central Nervous System Angiosarcoma

Genetic Tests for Central Nervous System Angiosarcoma

Anatomical Context for Central Nervous System Angiosarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Central Nervous System Angiosarcoma:

19
Inner Lining Of Blood Vessels

MalaCards organs/tissues related to Central Nervous System Angiosarcoma:

40
Heart, Bone, Breast, Spleen, Skin, Brain, Lung

Publications for Central Nervous System Angiosarcoma

Articles related to Central Nervous System Angiosarcoma:

# Title Authors PMID Year
1
Primary Central Nervous System Angiosarcoma. 61
31470162 2019
2
Metastatic Cardiac Angiosarcoma to the Lung, Spine, and Brain: A Case Report and Review of the Literature. 61
28803168 2017
3
Primary central nervous system angiosarcoma: a case report and literature review. 61
25388456 2015
4
Primary central nervous system angiosarcoma: two case reports. 61
22909122 2012

Variations for Central Nervous System Angiosarcoma

Expression for Central Nervous System Angiosarcoma

Search GEO for disease gene expression data for Central Nervous System Angiosarcoma.

Pathways for Central Nervous System Angiosarcoma

Pathways related to Central Nervous System Angiosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.79 PECAM1 CD34

GO Terms for Central Nervous System Angiosarcoma

Cellular components related to Central Nervous System Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell periphery GO:0071944 8.62 PECAM1 CD34

Biological processes related to Central Nervous System Angiosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 leukocyte migration GO:0050900 9.16 PECAM1 CD34
2 cell-cell adhesion GO:0098609 8.96 PECAM1 CD34
3 glomerular endothelium development GO:0072011 8.62 PECAM1 CD34

Sources for Central Nervous System Angiosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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