MCID: CNT109
MIFTS: 30

Central Nervous System Benign Neoplasm

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Benign Neoplasm

MalaCards integrated aliases for Central Nervous System Benign Neoplasm:

Name: Central Nervous System Benign Neoplasm 12 15
Benign Neoplasm of the Central Nervous System 29

Classifications:



External Ids:

Disease Ontology 12 DOID:0060090
ICD10 32 D33.9

Summaries for Central Nervous System Benign Neoplasm

Disease Ontology : 12 A central nervous system benign neoplasm that is characterized by lack of malignancy.

MalaCards based summary : Central Nervous System Benign Neoplasm, also known as benign neoplasm of the central nervous system, is related to gangliocytoma and hemangioblastoma. An important gene associated with Central Nervous System Benign Neoplasm is TSC2 (TSC Complex Subunit 2), and among its related pathways/superpathways are Integrated Breast Cancer Pathway and Neuroscience. Affiliated tissues include brain, spinal cord and kidney, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Central Nervous System Benign Neoplasm

Diseases related to Central Nervous System Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 248)
# Related Disease Score Top Affiliating Genes
1 gangliocytoma 32.8 SYP POMC KIAA1549 GFAP
2 hemangioblastoma 31.6 SYP GFAP ENO2
3 papilloma of choroid plexus 31.4 SYP GFAP ENO2
4 arteriovenous malformations of the brain 11.4
5 central nervous system leiomyoma 11.4
6 central nervous system lipoma 11.4
7 uterus perivascular epithelioid cell tumor 10.7 TSC2 TSC1
8 malignant melanocytic neoplasm of the peripheral nerve sheath 10.7 SYP ENO2
9 lung combined type small cell carcinoma 10.7 SYP GFAP
10 ureter small cell carcinoma 10.7 SYP ENO2
11 anal neuroendocrine tumor 10.7 SYP ENO2
12 sinonasal undifferentiated carcinoma 10.7 SYP ENO2
13 angiomyolipoma 10.7 TSC2 TSC1 MTOR
14 papillary tumor of the pineal region 10.7 SYP ENO2
15 small cell carcinoma of the bladder 10.7 SYP ENO2
16 cerebral primitive neuroectodermal tumor 10.7 SYP MYCN
17 urinary bladder small cell neuroendocrine carcinoma 10.7 SYP ENO2
18 intracranial primitive neuroectodermal tumor 10.7 SYP ENO2
19 bile duct mucinous adenocarcinoma 10.7 SYP ENO2
20 intracranial cysts 10.7 GFAP ENO2
21 nodular prostate 10.7 SYP ENO2
22 appendix carcinoid tumor 10.7 SYP ENO2
23 hepatic angiomyolipoma 10.7 TSC2 TSC1 MTOR
24 auditory system cancer 10.7 SYP ENO2
25 primitive neuroectodermal tumor of the cervix uteri 10.7 GFAP ENO2
26 cloacogenic carcinoma 10.7 SYP ENO2
27 thymus small cell carcinoma 10.7 SYP ENO2
28 mature teratoma of the ovary 10.6 SYP ENO2
29 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.6 SYP ENO2
30 pacinian tumor 10.6 NF1 ENO2
31 chiari malformation 10.6 SYP GFAP
32 cauda equina neoplasm 10.6 SYP ENO2
33 lissencephaly with cerebellar hypoplasia 10.6 TSC2 TSC1
34 duodenal benign neoplasm 10.6 SYP ENO2
35 lung meningioma 10.6 SYP NF2
36 ampulla of vater neoplasm 10.6 SYP ENO2
37 posterior pituitary gland neoplasm 10.6 SYP GFAP
38 kidney benign neoplasm 10.6 TSC2 TSC1 MTOR
39 suprasellar meningioma 10.6 POMC GFAP
40 desmoplastic infantile ganglioglioma 10.6 SYP MYCN GFAP
41 cervical neuroblastoma 10.6 SYP MYCN
42 lymphocytic hypophysitis 10.6 POMC ENO2
43 middle ear adenoma 10.6 SYP ENO2
44 epithelioid neurofibroma 10.6 NF2 NF1
45 large cell medulloblastoma 10.6 SYP MYCN KDM4C
46 tuberous sclerosis 1 10.6 TSC2 TSC1 MTOR
47 adult astrocytic tumour 10.6 LUC7L2 KIAA1549 IDH1
48 papillary ependymoma 10.6 SYP GFAP ENO2
49 nodular ganglioneuroblastoma 10.6 SYP MYCN ENO2
50 amyloid tumor 10.6 NF2 NF1

Graphical network of the top 20 diseases related to Central Nervous System Benign Neoplasm:



Diseases related to Central Nervous System Benign Neoplasm

Symptoms & Phenotypes for Central Nervous System Benign Neoplasm

GenomeRNAi Phenotypes related to Central Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

26 (show all 18)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-101 9.66 POMC
2 Increased shRNA abundance (Z-score > 2) GR00366-A-102 9.66 POMC TSC2
3 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.66 IDH1 POMC TSC1 TSC2
4 Increased shRNA abundance (Z-score > 2) GR00366-A-132 9.66 TSC2
5 Increased shRNA abundance (Z-score > 2) GR00366-A-136 9.66 IDH1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.66 IDH1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-147 9.66 IDH1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-166 9.66 TSC2
9 Increased shRNA abundance (Z-score > 2) GR00366-A-207 9.66 TSC2
10 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.66 POMC
11 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.66 POMC
12 Increased shRNA abundance (Z-score > 2) GR00366-A-39 9.66 IDH1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.66 TSC1
14 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.66 IDH1
15 Increased shRNA abundance (Z-score > 2) GR00366-A-82 9.66 TSC1
16 Increased shRNA abundance (Z-score > 2) GR00366-A-88 9.66 POMC
17 Increased shRNA abundance (Z-score > 2) GR00366-A-9 9.66 POMC
18 Increased shRNA abundance (Z-score > 2) GR00366-A-92 9.66 TSC2

MGI Mouse Phenotypes related to Central Nervous System Benign Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.93 ENO2 GFAP GNS KIAA1549 MTOR MYCN
2 nervous system MP:0003631 9.7 ENO2 GFAP GNS MTOR MYCN NF1
3 renal/urinary system MP:0005367 9.17 MTOR MYCN NF1 NF2 POMC TSC1

Drugs & Therapeutics for Central Nervous System Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Central Nervous System Benign Neoplasm

Genetic Tests for Central Nervous System Benign Neoplasm

Genetic tests related to Central Nervous System Benign Neoplasm:

# Genetic test Affiliating Genes
1 Benign Neoplasm of the Central Nervous System 29

Anatomical Context for Central Nervous System Benign Neoplasm

MalaCards organs/tissues related to Central Nervous System Benign Neoplasm:

40
Brain, Spinal Cord, Kidney, Lung, Pineal, Cerebellum, Colon

Publications for Central Nervous System Benign Neoplasm

Articles related to Central Nervous System Benign Neoplasm:

# Title Authors PMID Year
1
[Central neurocytoma: Study of 32 cases and review of the literature]. 61
20692674 2010
2
Dysembryoplastic neuroepithelial tumors: magnetic resonance imaging and magnetic resonance spectroscopy evaluation. 61
20079155 2009
3
Suprasellar melanocytoma: a case of primary radiotherapy and review of the literature. 61
12160139 2002

Variations for Central Nervous System Benign Neoplasm

Expression for Central Nervous System Benign Neoplasm

Search GEO for disease gene expression data for Central Nervous System Benign Neoplasm.

Pathways for Central Nervous System Benign Neoplasm

Pathways related to Central Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.81 TSC2 TSC1 NF1 MTOR
2 11.7 SYP POMC NF2 NF1 MYCN GFAP
3 11.54 TSC2 TSC1 MTOR
4 11.4 TSC2 TSC1 NF2 NF1 MTOR
5 11.36 TSC2 TSC1 MTOR
6 11.27 TSC2 TSC1 MTOR
7 11.06 TSC2 TSC1 MTOR
8 10.85 TSC2 TSC1 MTOR

GO Terms for Central Nervous System Benign Neoplasm

Cellular components related to Central Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 TSC1-TSC2 complex GO:0033596 8.62 TSC2 TSC1

Biological processes related to Central Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of macroautophagy GO:0016242 9.37 TSC1 MTOR
2 negative regulation of protein kinase activity GO:0006469 9.33 TSC2 NF2 NF1
3 regulation of cell-matrix adhesion GO:0001952 9.32 TSC1 NF1
4 anoikis GO:0043276 9.26 TSC2 MTOR
5 negative regulation of cell size GO:0045792 8.96 TSC1 MTOR
6 positive regulation of stress fiber assembly GO:0051496 8.8 TSC1 NF2 MTOR

Sources for Central Nervous System Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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