MCID: CNT109
MIFTS: 28

Central Nervous System Benign Neoplasm

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Benign Neoplasm

MalaCards integrated aliases for Central Nervous System Benign Neoplasm:

Name: Central Nervous System Benign Neoplasm 12 15
Benign Neoplasm of the Central Nervous System 29

Classifications:



External Ids:

Disease Ontology 12 DOID:0060090
ICD10 32 D33.9

Summaries for Central Nervous System Benign Neoplasm

Disease Ontology : 12 A nervous system benign neoplasm that is characterized by lack of malignancy.

MalaCards based summary : Central Nervous System Benign Neoplasm, also known as benign neoplasm of the central nervous system, is related to gangliocytoma and hemangioblastoma. An important gene associated with Central Nervous System Benign Neoplasm is TSC2 (TSC Complex Subunit 2), and among its related pathways/superpathways are Integrated Breast Cancer Pathway and Neuroscience. Affiliated tissues include brain, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Central Nervous System Benign Neoplasm

Diseases related to Central Nervous System Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 280)
# Related Disease Score Top Affiliating Genes
1 gangliocytoma 32.7 SYP POMC KIAA1549 GFAP ENO2
2 hemangioblastoma 31.6 SYP GFAP ENO2
3 papilloma of choroid plexus 31.5 SYP GFAP ENO2
4 arteriovenous malformations of the brain 11.4
5 central nervous system leiomyoma 11.4
6 central nervous system lipoma 11.4
7 malignant melanocytic neoplasm of the peripheral nerve sheath 10.7 SYP ENO2
8 gliofibroma 10.7 KIAA1549 GFAP
9 anal neuroendocrine tumor 10.7 SYP ENO2
10 breast neuroendocrine neoplasm 10.7 SYP ENO2
11 lung combined type small cell carcinoma 10.7 SYP GFAP
12 sinonasal undifferentiated carcinoma 10.7 SYP ENO2
13 intracranial cysts 10.7 GFAP ENO2
14 papillary tumor of the pineal region 10.7 SYP ENO2
15 small cell carcinoma of the bladder 10.7 SYP ENO2
16 pineal region teratoma 10.7 SYP ENO2
17 primitive neuroectodermal tumor of the cervix uteri 10.7 GFAP ENO2
18 intracranial primitive neuroectodermal tumor 10.7 SYP ENO2
19 bile duct mucinous adenocarcinoma 10.7 SYP ENO2
20 auditory system benign neoplasm 10.7 SYP ENO2
21 appendix carcinoid tumor 10.7 SYP ENO2
22 cerebral primitive neuroectodermal tumor 10.7 SYP MYCN
23 auditory system cancer 10.7 SYP ENO2
24 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.7 SYP ENO2
25 lung meningioma 10.6 SYP NF2
26 cauda equina neoplasm 10.6 SYP ENO2
27 duodenal benign neoplasm 10.6 SYP ENO2
28 nodular prostate 10.6 SYP ENO2
29 ampulla of vater neoplasm 10.6 SYP ENO2
30 heart cancer 10.6 TSC2 TSC1 MTOR
31 desmoplastic infantile ganglioglioma 10.6 SYP MYCN GFAP
32 kidney angiomyolipoma 10.6 TSC2 TSC1 MTOR
33 angiomyolipoma 10.6 TSC2 TSC1 MTOR
34 lymphocytic hypophysitis 10.6 POMC ENO2
35 urinary bladder small cell neuroendocrine carcinoma 10.6 SYP ENO2
36 ureter small cell carcinoma 10.6 SYP ENO2
37 cerebellar liponeurocytoma 10.6 SYP KIAA1549 ENO2
38 pacinian tumor 10.6 NF1 ENO2
39 kidney benign neoplasm 10.6 TSC2 TSC1 MTOR
40 epithelioid neurofibroma 10.6 NF2 NF1
41 middle ear adenoma 10.6 SYP ENO2
42 lissencephaly with cerebellar hypoplasia 10.6 TSC2 TSC1
43 laryngeal neuroendocrine tumor 10.6 SYP IDH1
44 horseshoe kidney 10.6 TSC2 SYP ENO2
45 jejunal neoplasm 10.6 SYP ENO2
46 corneal dystrophy, fleck 10.6 TSC2 TSC1 MTOR
47 cervical neuroblastoma 10.6 SYP MYCN ENO2
48 adrenal neuroblastoma 10.6 SYP MYCN ENO2
49 papillary ependymoma 10.6 SYP GFAP ENO2
50 nodular ganglioneuroblastoma 10.6 MYCN ENO2

Graphical network of the top 20 diseases related to Central Nervous System Benign Neoplasm:



Diseases related to Central Nervous System Benign Neoplasm

Symptoms & Phenotypes for Central Nervous System Benign Neoplasm

GenomeRNAi Phenotypes related to Central Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

26 (show all 14)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-101 9.47 POMC
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-117 9.47 TSC1
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-127 9.47 POMC
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-141 9.47 POMC
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-147 9.47 IDH1
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-166 9.47 TSC2
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-203 9.47 TSC1
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-206 9.47 TSC1
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-29 9.47 POMC
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-33 9.47 TSC1
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-47 9.47 IDH1
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-59 9.47 POMC
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-82 9.47 TSC1
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-9 9.47 POMC

MGI Mouse Phenotypes related to Central Nervous System Benign Neoplasm:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.73 ENO2 GFAP GNS KIAA1549 MTOR MYCN
2 nervous system MP:0003631 9.36 ENO2 GFAP GNS MTOR MYCN NF1

Drugs & Therapeutics for Central Nervous System Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Central Nervous System Benign Neoplasm

Genetic Tests for Central Nervous System Benign Neoplasm

Genetic tests related to Central Nervous System Benign Neoplasm:

# Genetic test Affiliating Genes
1 Benign Neoplasm of the Central Nervous System 29

Anatomical Context for Central Nervous System Benign Neoplasm

MalaCards organs/tissues related to Central Nervous System Benign Neoplasm:

40
Brain

Publications for Central Nervous System Benign Neoplasm

Articles related to Central Nervous System Benign Neoplasm:

# Title Authors PMID Year
1
[Central neurocytoma: Study of 32 cases and review of the literature]. 61
20692674 2010
2
Dysembryoplastic neuroepithelial tumors: magnetic resonance imaging and magnetic resonance spectroscopy evaluation. 61
20079155 2009
3
Suprasellar melanocytoma: a case of primary radiotherapy and review of the literature. 61
12160139 2002

Variations for Central Nervous System Benign Neoplasm

Expression for Central Nervous System Benign Neoplasm

Search GEO for disease gene expression data for Central Nervous System Benign Neoplasm.

Pathways for Central Nervous System Benign Neoplasm

Pathways related to Central Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.81 TSC2 TSC1 NF1 MTOR
2 11.7 SYP POMC NF2 NF1 MYCN GFAP
3
Show member pathways
11.63 TSC2 TSC1 MTOR
4 11.54 TSC2 TSC1 MTOR
5 11.4 TSC2 TSC1 NF2 NF1 MTOR
6 11.36 TSC2 TSC1 MTOR
7 11.27 TSC2 TSC1 MTOR
8 11.06 TSC2 TSC1 MTOR
9 10.85 TSC2 TSC1 MTOR

GO Terms for Central Nervous System Benign Neoplasm

Cellular components related to Central Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 TSC1-TSC2 complex GO:0033596 8.62 TSC2 TSC1

Biological processes related to Central Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of protein kinase activity GO:0006469 9.5 TSC2 NF2 NF1
2 regulation of cell-matrix adhesion GO:0001952 9.37 TSC1 NF1
3 anoikis GO:0043276 9.26 TSC2 MTOR
4 negative regulation of cell size GO:0045792 9.16 TSC1 MTOR
5 positive regulation of stress fiber assembly GO:0051496 9.13 TSC1 NF2 MTOR
6 positive regulation of glial cell proliferation GO:0060252 8.8 MTOR MIR125B1 GFAP

Sources for Central Nervous System Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....