MCID: CNT109
MIFTS: 30

Central Nervous System Benign Neoplasm

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Benign Neoplasm

MalaCards integrated aliases for Central Nervous System Benign Neoplasm:

Name: Central Nervous System Benign Neoplasm 12 15
Benign Neoplasm of the Central Nervous System 29

Classifications:



External Ids:

Disease Ontology 12 DOID:0060090
ICD10 33 D33.9

Summaries for Central Nervous System Benign Neoplasm

Disease Ontology : 12 A central nervous system benign neoplasm that is characterized by lack of malignancy.

MalaCards based summary : Central Nervous System Benign Neoplasm, also known as benign neoplasm of the central nervous system, is related to gangliocytoma and hemangioblastoma. An important gene associated with Central Nervous System Benign Neoplasm is SYP (Synaptophysin), and among its related pathways/superpathways are Integrated Breast Cancer Pathway and Thyroid hormone signaling pathway. Affiliated tissues include brain, and related phenotypes are Decreased cell migration and Increased cell migration

Related Diseases for Central Nervous System Benign Neoplasm

Diseases related to Central Nervous System Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 162)
# Related Disease Score Top Affiliating Genes
1 gangliocytoma 32.8 SYP RBFOX3 POMC
2 hemangioblastoma 31.6 SYP GFAP ENO2
3 arteriovenous malformations of the brain 11.4
4 central nervous system leiomyoma 11.4
5 central nervous system lipoma 11.4
6 carotid body cancer 10.8 SYP ENO2
7 lung combined type small cell carcinoma 10.8 SYP GFAP
8 urinary bladder small cell neuroendocrine carcinoma 10.8 SYP ENO2
9 malignant sertoli cell tumor 10.8 SYP ENO2
10 auditory system cancer 10.7 SYP ENO2
11 cellular ependymoma 10.7 SYP GFAP
12 sinonasal undifferentiated carcinoma 10.7 SYP ENO2
13 intracranial cysts 10.7 GFAP ENO2
14 primitive neuroectodermal tumor of the cervix uteri 10.7 GFAP ENO2
15 papillary tumor of the pineal region 10.7 SYP ENO2
16 small cell carcinoma of the bladder 10.7 SYP ENO2
17 extrahepatic bile duct adenocarcinoma 10.7 SYP ENO2
18 cutaneous ganglioneuroma 10.7 SYP ENO2
19 adrenal neuroblastoma 10.7 MYCN ENO2
20 melanotic medulloblastoma 10.7 GFAP ENO2
21 pancreatic somatostatinoma 10.7 SYP ENO2
22 hepatic angiomyolipoma 10.7 TSC2 MTOR
23 middle ear adenoma 10.7 SYP ENO2
24 chordoid meningioma 10.7 SYP GFAP
25 orbital cancer 10.7 SYP ENO2
26 sensory organ benign neoplasm 10.7 SYP ENO2
27 partial motor epilepsy 10.7 SYP RBFOX3
28 atypical follicular adenoma 10.6 SYP ENO2
29 gallbladder small cell carcinoma 10.6 SYP ENO2
30 pulmonary large cell neuroendocrine carcinoma 10.6 SYP ENO2
31 desmoplastic infantile ganglioglioma 10.6 SYP MYCN GFAP
32 lymphocytic hypophysitis 10.6 POMC ENO2
33 chiari malformation 10.6 SYP GFAP
34 malignant glandular tumor of peripheral nerve sheath 10.6 SYP NF1
35 clear cell ependymoma 10.6 SYP GFAP ENO2
36 nodular ganglioneuroblastoma 10.6 SYP MYCN ENO2
37 central nervous system germ cell tumor 10.6 POMC GFAP
38 central nervous system primitive neuroectodermal neoplasm 10.6 SYP GFAP ENO2
39 ganglioneuroblastoma 10.6 SYP MYCN ENO2
40 cerebral neuroblastoma 10.6 SYP GFAP ENO2
41 horseshoe kidney 10.6 TSC2 SYP ENO2
42 astroblastoma 10.6 SYP GFAP ENO2
43 pineal gland cancer 10.6 SYP GFAP ENO2
44 askin's tumor 10.6 MYCN ENO2
45 gliofibroma 10.6 NF1 GFAP
46 cerebellar medulloblastoma 10.6 GFAP ENO2
47 cerebellum cancer 10.6 SYP ENO2
48 melanotic neuroectodermal tumor 10.6 SYP GFAP ENO2
49 pineocytoma 10.6 SYP GFAP ENO2
50 cerebellar astrocytoma 10.6 KIAA1549 IDH1

Graphical network of the top 20 diseases related to Central Nervous System Benign Neoplasm:



Diseases related to Central Nervous System Benign Neoplasm

Symptoms & Phenotypes for Central Nervous System Benign Neoplasm

GenomeRNAi Phenotypes related to Central Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased cell migration GR00055-A-1 9.35 CTNNB1 MTOR NF1 NF2 TSC1
2 Increased cell migration GR00055-A-3 8.92 CTNNB1 MTOR NF1 NF2

MGI Mouse Phenotypes related to Central Nervous System Benign Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.32 CTNNB1 ENO2 GFAP GNS KIAA1549 MTOR
2 growth/size/body region MP:0005378 10.21 CTNNB1 ENO2 GFAP IDH1 MTOR MYCN
3 cellular MP:0005384 10.2 CTNNB1 ENO2 GFAP GNS MTOR MYCN
4 mortality/aging MP:0010768 10.15 CTNNB1 GFAP GNS IDH1 MTOR MYCN
5 nervous system MP:0003631 9.97 CTNNB1 ENO2 GFAP GNS MTOR MYCN
6 liver/biliary system MP:0005370 9.95 CTNNB1 MYCN NF1 NF2 POMC TSC1
7 muscle MP:0005369 9.87 CTNNB1 GFAP MTOR MYCN NF1 OLIG2
8 neoplasm MP:0002006 9.8 CTNNB1 NF1 NF2 OLIG2 POMC TSC1
9 renal/urinary system MP:0005367 9.56 CTNNB1 MTOR MYCN NF1 NF2 POMC
10 respiratory system MP:0005388 9.28 CTNNB1 ENO2 IDH1 MTOR MYCN NF1

Drugs & Therapeutics for Central Nervous System Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Central Nervous System Benign Neoplasm

Genetic Tests for Central Nervous System Benign Neoplasm

Genetic tests related to Central Nervous System Benign Neoplasm:

# Genetic test Affiliating Genes
1 Benign Neoplasm of the Central Nervous System 29

Anatomical Context for Central Nervous System Benign Neoplasm

MalaCards organs/tissues related to Central Nervous System Benign Neoplasm:

41
Brain

Publications for Central Nervous System Benign Neoplasm

Articles related to Central Nervous System Benign Neoplasm:

# Title Authors PMID Year
1
[Central neurocytoma: Study of 32 cases and review of the literature]. 38
20692674 2010
2
Dysembryoplastic neuroepithelial tumors: magnetic resonance imaging and magnetic resonance spectroscopy evaluation. 38
20079155 2009
3
Suprasellar melanocytoma: a case of primary radiotherapy and review of the literature. 38
12160139 2002

Variations for Central Nervous System Benign Neoplasm

Expression for Central Nervous System Benign Neoplasm

Search GEO for disease gene expression data for Central Nervous System Benign Neoplasm.

Pathways for Central Nervous System Benign Neoplasm

GO Terms for Central Nervous System Benign Neoplasm

Cellular components related to Central Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 TSC1-TSC2 complex GO:0033596 8.62 TSC2 TSC1

Biological processes related to Central Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of oligodendrocyte differentiation GO:0048714 9.54 OLIG2 MTOR
2 regulation of myelination GO:0031641 9.52 MTOR CTNNB1
3 positive regulation of glial cell proliferation GO:0060252 9.51 MTOR GFAP
4 regulation of osteoclast differentiation GO:0045670 9.49 MTOR CTNNB1
5 negative regulation of oxidative stress-induced neuron death GO:1903204 9.48 TSC1 CTNNB1
6 negative regulation of macroautophagy GO:0016242 9.46 TSC1 MTOR
7 ectoderm development GO:0007398 9.43 NF2 CTNNB1
8 negative regulation of protein kinase activity GO:0006469 9.43 TSC2 NF2 NF1
9 regulation of cell-matrix adhesion GO:0001952 9.4 TSC1 NF1
10 negative regulation of oligodendrocyte differentiation GO:0048715 9.37 NF1 CTNNB1
11 negative regulation of cell proliferation GO:0008285 9.35 TSC2 TSC1 NF2 NF1 CTNNB1
12 anoikis GO:0043276 9.32 TSC2 MTOR
13 negative regulation of cell size GO:0045792 9.16 TSC1 MTOR
14 positive regulation of stress fiber assembly GO:0051496 8.8 TSC1 NF2 MTOR

Molecular functions related to Central Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 kinase binding GO:0019900 8.8 MYCN GFAP CTNNB1

Sources for Central Nervous System Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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