MCID: CNT109
MIFTS: 26

Central Nervous System Benign Neoplasm

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Benign Neoplasm

MalaCards integrated aliases for Central Nervous System Benign Neoplasm:

Name: Central Nervous System Benign Neoplasm 12 15
Benign Neoplasm of the Central Nervous System 30

Classifications:



External Ids:

Disease Ontology 12 DOID:0060090

Summaries for Central Nervous System Benign Neoplasm

Disease Ontology : 12 A benign neoplasm of the central nervous system that is characterized by lack of malignancy.

MalaCards based summary : Central Nervous System Benign Neoplasm, also known as benign neoplasm of the central nervous system, is related to gangliocytoma and hemangioblastoma. An important gene associated with Central Nervous System Benign Neoplasm is SYP (Synaptophysin), and among its related pathways/superpathways are Neuroscience and G alpha (s) signalling events. Related phenotypes are behavior/neurological and homeostasis/metabolism

Related Diseases for Central Nervous System Benign Neoplasm

Diseases related to Central Nervous System Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 200)
# Related Disease Score Top Affiliating Genes
1 gangliocytoma 32.2 POMC RBFOX3 SYP
2 hemangioblastoma 31.0 ENO2 GFAP SYP
3 pancreatic somatostatinoma 10.5 ENO2 SYP
4 sensory organ benign neoplasm 10.5 ENO2 SYP
5 cutaneous ganglioneuroma 10.5 ENO2 SYP
6 mucinous ovarian cystadenoma 10.5 ENO2 SYP
7 extrahepatic bile duct adenocarcinoma 10.5 ENO2 SYP
8 rhabdoid cancer 10.5 ENO2 SYP
9 cerebellum cancer 10.5 ENO2 SYP
10 angiomyoma 10.5 ENO2 SYP
11 orbital cancer 10.5 ENO2 SYP
12 extraosseous chondrosarcoma 10.5 ENO2 SYP
13 cervical clear cell adenocarcinoma 10.5 ENO2 SYP
14 middle ear adenoma 10.5 ENO2 SYP
15 endometrial small cell carcinoma 10.5 ENO2 SYP
16 desmoplastic small round cell tumor 10.5 ENO2 SYP
17 papillary tumor of the pineal region 10.5 ENO2 SYP
18 cerebellar medulloblastoma 10.5 ENO2 GFAP
19 medulloepithelioma 10.5 GFAP SYP
20 perivascular epithelioid cell tumor 10.5 SYP TSC2
21 anaplastic ependymoma 10.5 GFAP SYP
22 chiari malformation 10.5 GFAP SYP
23 microcystic meningioma 10.5 ENO2 GFAP
24 askin's tumor 10.5 ENO2 MYCN
25 male reproductive organ benign neoplasm 10.5 POMC SYP
26 pancreatic endocrine carcinoma 10.5 POMC SYP
27 hepatic angiomyolipoma 10.5 MTOR TSC2
28 kidney angiomyolipoma 10.5 MTOR TSC2
29 suprasellar meningioma 10.4 GFAP POMC
30 carotid body cancer 10.4 ENO2 SYP
31 malignant sertoli cell tumor 10.4 ENO2 SYP
32 trigeminal nerve neoplasm 10.4 GFAP NF1
33 neurilemmoma of the fifth cranial nerve 10.4 GFAP NF1
34 duodenal somatostatinoma 10.4 ENO2 NF1
35 atypical neurofibroma 10.4 GFAP NF1
36 intracranial cysts 10.4 ENO2 GFAP
37 ependymoma 10.4 ENO2 GFAP SYP
38 lung combined type small cell carcinoma 10.4 GFAP SYP
39 primitive neuroectodermal tumor of the cervix uteri 10.3 ENO2 GFAP
40 glioma susceptibility 1 10.3 GFAP IDH1
41 central nervous system primitive neuroectodermal neoplasm 10.3 ENO2 GFAP SYP
42 clear cell ependymoma 10.3 ENO2 GFAP SYP
43 cerebral neuroblastoma 10.3 ENO2 GFAP SYP
44 teratoma 10.3 ENO2 GFAP SYP
45 astroblastoma 10.3 ENO2 GFAP SYP
46 mixed glioma 10.3 GFAP IDH1
47 pineal gland cancer 10.3 ENO2 GFAP SYP
48 melanotic neuroectodermal tumor 10.3 ENO2 GFAP SYP
49 desmoplastic infantile ganglioglioma 10.3 GFAP MYCN SYP
50 melanotic medulloblastoma 10.3 ENO2 GFAP

Graphical network of the top 20 diseases related to Central Nervous System Benign Neoplasm:



Diseases related to Central Nervous System Benign Neoplasm

Symptoms & Phenotypes for Central Nervous System Benign Neoplasm

MGI Mouse Phenotypes related to Central Nervous System Benign Neoplasm:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.18 AVP ENO2 GFAP GNS KIAA1549 MTOR
2 homeostasis/metabolism MP:0005376 10.06 AVP CHGA GFAP IDH1 KIAA1549 MTOR
3 mortality/aging MP:0010768 10 AVP CHGA GFAP GNS IDH1 MTOR
4 cardiovascular system MP:0005385 9.97 CHGA GFAP MTOR MYCN NF1 POMC
5 nervous system MP:0003631 9.9 AVP CHGA ENO2 GFAP GNS MTOR
6 normal MP:0002873 9.56 AVP GFAP MTOR MYCN NF1 SYP
7 renal/urinary system MP:0005367 9.17 AVP CHGA MTOR MYCN NF1 POMC

Drugs & Therapeutics for Central Nervous System Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Central Nervous System Benign Neoplasm

Genetic Tests for Central Nervous System Benign Neoplasm

Genetic tests related to Central Nervous System Benign Neoplasm:

# Genetic test Affiliating Genes
1 Benign Neoplasm of the Central Nervous System 30

Anatomical Context for Central Nervous System Benign Neoplasm

Publications for Central Nervous System Benign Neoplasm

Variations for Central Nervous System Benign Neoplasm

Expression for Central Nervous System Benign Neoplasm

Search GEO for disease gene expression data for Central Nervous System Benign Neoplasm.

Pathways for Central Nervous System Benign Neoplasm

Pathways related to Central Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.81 AVP ENO2 GFAP MYCN NF1 POMC
2 11.5 AVP POMC VIP
3 11.18 MTOR NF1 TSC2

GO Terms for Central Nervous System Benign Neoplasm

Cellular components related to Central Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 perikaryon GO:0043204 9.33 ENO2 RBFOX3 VIP
2 lysosome GO:0005764 9.26 GFAP GNS MTOR TSC2
3 secretory granule GO:0030141 8.8 AVP CHGA POMC

Biological processes related to Central Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of long-term neuronal synaptic plasticity GO:0048169 9.32 NF1 SYP
2 mRNA stabilization GO:0048255 9.26 MTOR VIP
3 positive regulation of glial cell proliferation GO:0060252 9.16 GFAP MTOR
4 anoikis GO:0043276 8.96 MTOR TSC2
5 positive regulation of endothelial cell proliferation GO:0001938 8.8 MTOR NF1 VIP

Molecular functions related to Central Nervous System Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 8.8 AVP POMC VIP

Sources for Central Nervous System Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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