MCID: CNT035
MIFTS: 63

Central Nervous System Disease

Categories: Neuronal diseases, Immune diseases

Aliases & Classifications for Central Nervous System Disease

Summaries for Central Nervous System Disease

Disease Ontology : 12 A nervous system disease that affects either the spinal cord (myelopathy) or brain (encephalopathy) of the central nervous system.

MalaCards based summary : Central Nervous System Disease, also known as central nervous system diseases, is related to meningitis and nervous system disease, and has symptoms including headache, hemiplegia and hyperexplexia. An important gene associated with Central Nervous System Disease is HAR1A (Highly Accelerated Region 1A
Herein,we review emerging evidence that highlights the expression and function of lncRNAs in the CNS and suggests that lncRNA deregulation is an important factor in various CNS pathologies including neurodevelopmental,neurodegenerative and neuroimmunological disorders,primary brain tumors,and psychiatric diseases. The lncRNA HAR1F is transcribed from one of these regions and specifically co-expressed in Cajal-Retzius cells of the human neocortex with the critical neural factor RELN,which mediates seminal neural developmental processes and is implicated in the pathophysiology of a broad range of neurological and psychiatric disorders.
Dysfunction Pattern: ), and among its related pathways/superpathways are Tuberculosis and Bacterial infections in CF airways. The drugs Ritonavir and Propofol have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and testes, and related phenotypes are cellular and homeostasis/metabolism

Wikipedia : 76 Central nervous system diseases, also known as central nervous system disorders, are a group of... more...

Related Diseases for Central Nervous System Disease

Diseases in the Nervous System Disease family:

Autoimmune Disease of Central Nervous System Congenital Nervous System Abnormality
Central Nervous System Disease

Diseases related to Central Nervous System Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 173)
# Related Disease Score Top Affiliating Genes
1 meningitis 33.4 IFNG IL1B TLR9
2 nervous system disease 31.9 APOE APP BACE1 CCR1 CXCR3 GC
3 multiple sclerosis 31.5 APOE CCR1 CXCR3 IFNG IL1B MOG
4 mouth disease 31.4 IFNG IL1B TLR9 TRPV1
5 chlamydia 31.3 IFNG IL1B NOS2
6 neuroblastoma 30.9 APP BACE1 H19 PRNP PROM1
7 crohn's colitis 11.3 IFNG IL1B NOS2
8 eales disease 11.3 IFNG IL1B NOS2
9 neuritis 11.3 IFNG IL1B MOG
10 cerebral hemorrhage 11.3 APP IL1B PRNP
11 lichen disease 11.3 CXCR3 IFNG TLR9
12 allergic contact dermatitis 11.3 CXCR3 IFNG IL1B
13 tonsillitis 11.3 IFNG IL1B TLR9
14 lymphadenitis 11.3 CXCR3 IFNG IL1B
15 senile plaque formation 11.3 APOE APP
16 lacrimal apparatus disease 11.3 IL1B TLR9 TRPV1
17 bone inflammation disease 11.3 IFNG IL1B TLR9 TRPV1
18 genetic prion diseases 11.3 APOE PRNP
19 intestinal disease 11.2 IFNG IL1B TLR9 TRPV1
20 hypersensitivity reaction disease 11.2 IFNG IL1B TLR9 TRPV1
21 stomach disease 11.2 IL1B TLR9 TRPV1
22 visceral leishmaniasis 11.2 IFNG IL1B NOS2 TLR9
23 respiratory system disease 11.2 IFNG IL1B TLR9 TRPV1
24 gait apraxia 11.2 APOE APP PSEN1
25 leishmaniasis 11.2 IFNG IL1B NOS2 TLR9
26 familial idiopathic basal ganglia calcification 11.2 APOE APP PSEN1
27 contact dermatitis 11.2 CXCR3 IFNG IL1B
28 autoinflammation, lipodystrophy, and dermatosis syndrome 11.2 IFNG IL1B NOS2
29 immune system disease 11.2 IFNG IL1B TLR9 TRPV1
30 female reproductive system disease 11.2 IL1B TLR9 TRPV1
31 primary bacterial infectious disease 11.2 IFNG IL1B TLR9
32 prion disease 11.2 APP IL1B PRNP
33 gastrointestinal system disease 11.2 IFNG IL1B TLR9 TRPV1
34 colitis 11.2 IFNG IL1B NOS2 TLR9
35 inclusion body myositis 11.2 APOE APP BACE1 CXCR3
36 glucose metabolism disease 11.2 BACE1 IL1B TLR9 TRPV1
37 behcet syndrome 11.2 CCR1 IFNG IL1B TLR9
38 alzheimer disease 2 11.2 APOE APP PSEN1
39 acquired metabolic disease 11.2 BACE1 IL1B TLR9 TRPV1
40 arteries, anomalies of 11.2 APOE IL1B TLR9 TRPV1
41 toxoplasmosis 11.2 IFNG IL1B TLR9
42 bronchial disease 11.2 IL1B TLR9 TRPV1
43 neuronitis 11.2
44 dermatitis, atopic 11.2 CXCR3 IFNG TLR9 TRPV1
45 autoimmune disease 11.2 CXCR3 IFNG IL1B MOG TLR9
46 pick disease of brain 11.2 APOE APP PSEN1
47 staphylococcal toxic shock syndrome 11.2 IFNG IL1B
48 pulmonary fibrosis, idiopathic 11.2 CXCR3 IFNG IL1B TLR9
49 aphasia 11.2 APOE APP PRNP PSEN1
50 reproductive system disease 11.2 IL1B TLR9 TRPV1

Graphical network of the top 20 diseases related to Central Nervous System Disease:



Diseases related to Central Nervous System Disease

Symptoms & Phenotypes for Central Nervous System Disease

UMLS symptoms related to Central Nervous System Disease:


headache, hemiplegia, hyperexplexia

MGI Mouse Phenotypes related to Central Nervous System Disease:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 10.4 MOG IFNG MTDH NOS2 PRNP TLR9
2 homeostasis/metabolism MP:0005376 10.35 IFNG MTDH NOS2 IL1B HTT PRNP
3 cardiovascular system MP:0005385 10.31 IFNG MTDH NOS2 IL1B HTT PROM1
4 hematopoietic system MP:0005397 10.31 MOG IFNG MTDH NOS2 IL1B HTT
5 immune system MP:0005387 10.3 MOG IFNG MTDH NOS2 IL1B PRNP
6 behavior/neurological MP:0005386 10.29 HTT MOG IFNG TRPV1 PSEN1 PRNP
7 growth/size/body region MP:0005378 10.29 HTT MOG IFNG IL1B PSEN1 PRNP
8 mortality/aging MP:0010768 10.25 IFNG MTDH NOS2 IL1B HTT PRNP
9 integument MP:0010771 10.17 IFNG MTDH NOS2 IL1B PRNP TRPV1
10 nervous system MP:0003631 10.03 MOG IFNG IL1B HTT PSEN1 PRNP
11 muscle MP:0005369 9.97 MOG IFNG PSEN1 PRNP NOS2 BACE1
12 neoplasm MP:0002006 9.87 MTDH IFNG IL1B PROM1 TRPV1 NOS2
13 no phenotypic analysis MP:0003012 9.76 HTT IFNG PRNP PROM1 TRPV1 APOE
14 normal MP:0002873 9.61 HTT MTDH IFNG PSEN1 PRNP PROM1
15 renal/urinary system MP:0005367 9.23 IFNG PSEN1 TLR9 TRPV1 NOS2 APOE

Drugs & Therapeutics for Central Nervous System Disease

Drugs for Central Nervous System Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 1262)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ritonavir Approved, Investigational Phase 4 155213-67-5 392622
2
Propofol Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 2078-54-8 4943
3
Sevoflurane Approved, Vet_approved Phase 4,Phase 2,Not Applicable 28523-86-6 5206
4
Clobazam Approved, Illicit Phase 4,Phase 3,Phase 2 22316-47-8 2789
5
Methylprednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 83-43-2 6741
6
Prednisolone Approved, Vet_approved Phase 4,Phase 3,Phase 1,Phase 2 50-24-8 5755
7
Lamotrigine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 84057-84-1 3878
8
Valproic Acid Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 99-66-1 3121
9
Dexmedetomidine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 113775-47-6 68602 5311068
10
Dopamine Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 51-61-6, 62-31-7 681
11
Levodopa Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59-92-7 6047
12
Baclofen Approved Phase 4,Phase 2,Not Applicable 1134-47-0 2284
13
Mannitol Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 69-65-8 453 6251
14
Midazolam Approved, Illicit Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 59467-70-8 4192
15
Morphine Approved, Investigational Phase 4,Phase 2,Phase 3,Not Applicable 57-27-2 5288826
16
Betamethasone Approved, Vet_approved Phase 4 378-44-9 9782
17
Curcumin Approved, Investigational Phase 4,Phase 2,Phase 1 458-37-7 969516
18
Milnacipran Approved, Investigational Phase 4,Not Applicable 92623-85-3 65833
19
Ibuprofen Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 15687-27-1 3672
20
Acetylcholine Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 51-84-3 187
21
Lidocaine Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 137-58-6 3676
22
Benzocaine Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable,Early Phase 1 1994-09-7, 94-09-7 2337
23
Remifentanil Approved Phase 4,Phase 3,Not Applicable 132875-61-7 60815
24
Sufentanil Approved, Investigational Phase 4,Phase 2 56030-54-7 41693
25
Hydrochlorothiazide Approved, Vet_approved Phase 4,Phase 2 58-93-5 3639
26
Perindopril Approved Phase 4 107133-36-8, 82834-16-0 107807
27
Citalopram Approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 59729-33-8 2771
28
Huperzine A Approved, Investigational Phase 4,Phase 2,Phase 1,Not Applicable 102518-79-6
29
Angiotensin II Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 68521-88-0, 4474-91-3, 11128-99-7 172198 65143
30
Candesartan cilexetil Approved Phase 4,Phase 2,Phase 3 145040-37-5 2540
31
Amphotericin B Approved, Investigational Phase 4,Phase 3,Phase 2,Not Applicable 1397-89-3 14956 5280965
32
Miconazole Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 22916-47-8 4189
33
Lactulose Approved Phase 4,Phase 3,Phase 2,Not Applicable 4618-18-2 11333
34
Zinc Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 7440-66-6 23994
35
Donepezil Approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 120014-06-4 3152
36
Memantine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable,Early Phase 1 19982-08-2 4054
37
Ketamine Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Not Applicable 6740-88-1 3821
38
Pregabalin Approved, Illicit, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 148553-50-8 5486971
39
Aspirin Approved, Vet_approved Phase 4,Phase 2,Phase 3,Phase 1,Early Phase 1,Not Applicable 50-78-2 2244
40
Rivaroxaban Approved Phase 4,Phase 2,Phase 3,Not Applicable 366789-02-8
41
Nitrous oxide Approved, Vet_approved Phase 4,Not Applicable 10024-97-2 948
42
Rivastigmine Approved, Investigational Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 123441-03-2 77991
43
Atenolol Approved Phase 4,Phase 3 29122-68-7 2249
44
Valsartan Approved, Investigational Phase 4,Not Applicable 137862-53-4 60846
45
Hydrocortisone Approved, Vet_approved Phase 4,Phase 3,Phase 2,Phase 1,Not Applicable 50-23-7 5754
46
Prednisone Approved, Vet_approved Phase 4,Phase 3,Phase 2 53-03-2 5865
47
Aripiprazole Approved, Investigational Phase 4,Phase 3,Phase 1 129722-12-9 60795
48
Heparin Approved, Investigational Phase 4,Phase 2,Phase 3,Phase 1 9005-49-6 772 46507594
49 Nadroparin Approved, Investigational Phase 4 9041-08-1
50
Clopidogrel Approved Phase 4,Phase 3,Phase 2,Early Phase 1,Not Applicable 120202-66-6, 113665-84-2 60606

Interventional clinical trials:

(show top 50) (show all 10000)
# Name Status NCT ID Phase Drugs
1 Protease Inhibitor Monotherapy Versus Ongoing Triple-therapy in the Long Term Management of HIV Infection (PIVOT) Unknown status NCT01230580 Phase 4 Protease Inhibitor;Standard-of-care Antiretroviral therapy
2 Anesthesia Induction in Patients Undergoing Surgery for Cervical Myelopathy Unknown status NCT01052337 Phase 4 anaesthetics: sevofluorane
3 Clobazam Adjunctive Treatment of Adults With Refractory Focal Epilepsy Unknown status NCT02726919 Phase 4 Clobazam
4 Immunotherapy in Intractable Cryptogenic Epilepsy Patients With Autoimmune Antibody Unknown status NCT02695797 Phase 4 Prednisolone
5 NIMIP: Non Invasive Measurement of the Intracranial Pressure Unknown status NCT01685450 Phase 4
6 The Impact of Reducing Overtreatment on Quality of Life in Children With Refractory Epilepsy Unknown status NCT00647322 Phase 4
7 Hormone Profiles in Adults With Newly Diagnosed Epilepsy Unknown status NCT00137709 Phase 4 Sodium valproate;Lamotrigine
8 Study to Improve the Treatment of Epilepsy (SITE) Unknown status NCT00133081 Phase 4 All registered antiepileptic drugs
9 Exoskeletons for Spinal Cord Injury: A Feasibility Study Unknown status NCT01943669 Phase 4
10 Eyegaze Systems for Spinal Cord Injury: A Feasibility Study Unknown status NCT01943656 Phase 4
11 Consequence of Dexmedetomidine on Emergence Deliruim After Sevoflurane Anesthesia in Children With Cerebral Palsy Unknown status NCT02244515 Phase 4 dexmedetomidine
12 Dopamine Treatment in Children With Cerebral Palsy With Dystonia- A Double Blind Controlled Study Unknown status NCT01361373 Phase 4 L- DOPA;placebo
13 Compare Tolerability of an Overnight Switch to Gradual Switch Between Two Different Forms of Depakote Unknown status NCT00312676 Phase 4
14 Functional Electrical Stimulation-Assisted Walking: Reduction of Secondary Complications Due to Spinal Cord Injury Unknown status NCT00201968 Phase 4
15 Does Oral Baclofen Improve Care and Comfort in Spastic Children in Nursing Homes? Unknown status NCT00752934 Phase 4 oral baclofen + placebo;placebo + oral baclofen
16 A Clinical Trial of the Effect of Midazolam on the Cerebral Metabolism and Inflammatory Response in Patients With Moderate and Severe Traumatic Brain Injury Unknown status NCT02071407 Phase 4 Midazolam;Placebo
17 Growth Hormone and Brain Functioning After Traumatic Brain Injury Unknown status NCT01699308 Phase 4 Genotropin (somatropin)
18 The CAPTAIN Trial: Cerebrolysin Asian Pacific Trial in Acute Brain Injury and Neurorecovery Unknown status NCT01606111 Phase 4 Cerebrolysin;0.9% NaCl, saline
19 Effect of Rozerem on Sleep Among People With Traumatic Brain Injury Unknown status NCT01207050 Phase 4 Ramelteon
20 GON-block in Chronic Migraine: a Randomized, Double- Blind, Placebo-controlled Study Unknown status NCT02686983 Phase 4 Betamethasone and local anesthetic
21 The Combined Effects of omega3 Fatty Acids and Curcumin Supplementation on Inflammatory and Endothelial Factors in Migraine Patients Unknown status NCT02532023 Phase 4
22 Occipital Transcutaneous Stimulation in Chronic Migraine Unknown status NCT02307071 Phase 4
23 Preventive Treatment of Episodic and Chronic Migraine Unknown status NCT01319825 Phase 4 milnacipran
24 A Double-blind, Placebo-controlled Pilot Study to Collect and Evaluate Data on the Use of Intravenous Ibuprofen in the Treatment of an Acute Migraine Attack Unknown status NCT01230411 Phase 4 Ibuprofen
25 American Migraine Prevention Study Unknown status NCT00363506 Phase 4
26 Botox for Neurogenic Detrusor Overactivity and the Prevention of Autonomic Dysreflexia Following SCI Unknown status NCT02298660 Phase 4 BOTOX
27 The Effect of Dexmedetomidine to Cognition of Geriatrics in Prolonged Surgery Unknown status NCT02123355 Phase 4 Induction of anesthesia;Sevoflurane, remifentanil ,vecuronium;Dexmedetomidine;Placebo
28 Effects of Cerebrolysin Combined With Rehabilitation on Motor Recovery in Stroke Unknown status NCT02768571 Phase 4 Cerebrolysin;Placebo
29 Effectiveness and Safety of Yiqitongluo Granule for Stroke Unknown status NCT02604654 Phase 4 Yiqitongluo granule
30 The Safety and Efficacy Study of High Dose Atorvastatin After Thrombolytic Treatment in Acute Ischemic Stroke Unknown status NCT02452502 Phase 4
31 4-point vs 4-roll Canne as Walking Aids After Stroke Unknown status NCT02279069 Phase 4
32 A Clinical Trial of Danhong Injection in Treating Acute Ischemic Stroke Unknown status NCT02152280 Phase 4 Danhong Injection;Normal Saline
33 FINGER Robot Therapy Study Unknown status NCT02048826 Phase 4
34 Stratification of Blood Pressure Control Against Progress of Cerebral Small Vessel Diseases in Poststroke Patients Unknown status NCT01819441 Phase 4 Azelnidipine;Perindopril;hydrochlorothiazide
35 Creative Therapy to Affect Stroke Outcomes Unknown status NCT01455155 Phase 4
36 Effects on Clinical and Functional Outcome of Escitalopram in Adult Stroke Patients Unknown status NCT00967408 Phase 4 Escitalopram;Placebo
37 Functional Electrical Stimulation (FES) Assisted Walking: Enhancement of Walking Function After Stroke Unknown status NCT00552916 Phase 4
38 Early Warning and Optimization Strategy in Carotid Endarterectomy Unknown status NCT01210937 Phase 4
39 Huperzine-A to Help With Mental Problems and the Inability to Care for Onself in Patients With Schizophrenia Unknown status NCT01012830 Phase 4 Huperzine A
40 Acute Candesartan Cilexetil Outcomes Stroke Trial (ACCOST) Unknown status NCT00108706 Phase 4 Candesartan
41 The Impact of Botulinum Toxin Treatment in Quality of Life of Cervical Dystonia Patients Unknown status NCT01664013 Phase 4 Nuronox
42 Efficacy and Safety of DBS of the GPi in Patients With Primary Generalized and Segmental Dystonia Unknown status NCT00142259 Phase 4
43 Efficacy of Intrathecal Administration of Liposomal Amphotericin B in Cryptococcal Meningitis Unknown status NCT02686853 Phase 4 Liposomal amphotericin B
44 Trial Comparing Sedation for Endoscopy With Propofol Versus Midazolam in Cirrhotics Unknown status NCT01356121 Phase 4 Propofol;Midazolam
45 Secondary Prophylaxis of Hepatic Encephalopathy in Cirrhosis Unknown status NCT01178372 Phase 4 Lactulose;Probiotics(VSL#3)
46 Primary Prophylaxis of Hepatic Encephalopathy in Patients With Cirrhosis Unknown status NCT01175538 Phase 4 Lactulose;Lactulose
47 Evaluation of the Efficacy and Safety of Levothyroxine in Brain Death Organ Donors: a Randomized Controled Trial Unknown status NCT02211053 Phase 4 Levothyroxine;placebo
48 Intensive Versus Nonintensive Insulin Therapy for Hyperglycemia After Traumatic Brain Injury Unknown status NCT02161055 Phase 4 Insulin
49 Antibody Response of a Boosted Japanese Encephalitis Chimeric Virus Vaccine (JE-CV) in Children Unknown status NCT01954810 Phase 4
50 Therapeutic Efficacy of Oral L-Ornithine-L-Aspartate on Minimal Encephalopathy Unknown status NCT00896831 Phase 4 L-ornithine-L-aspartate;placebo

Search NIH Clinical Center for Central Nervous System Disease

Cochrane evidence based reviews: central nervous system diseases

Genetic Tests for Central Nervous System Disease

Anatomical Context for Central Nervous System Disease

MalaCards organs/tissues related to Central Nervous System Disease:

41
Brain, Spinal Cord, Testes, Bone, Pituitary, Heart, Bone Marrow

Publications for Central Nervous System Disease

Articles related to Central Nervous System Disease:

(show top 50) (show all 318)
# Title Authors Year
1
Predicting the incidence and timing of central nervous system disease in metastatic melanoma: Implications for surveillance and preventative therapy. ( 29332716 )
2018
2
Infliximab-Associated Chronic Inflammatory Central Nervous System Disease and Peroneal Nerve Injury in a Psoriatic Patient Refractory to Treatment: Case Report with 10-Year Follow-Up. ( 29515419 )
2018
3
A matrix metalloproteinase 9 (MMP9) gene single nucleotide polymorphism is associated with predisposition to tick-borne encephalitis virus-induced severe central nervous system disease. ( 29496490 )
2018
4
Stem cells in the treatment of central nervous system disease. ( 29523970 )
2018
5
Inhibition of calcium dependent protein kinase 1 (CDPK1) by pyrazolopyrimidine analogs decreases establishment and reoccurrence of central nervous system disease by Toxoplasma gondii. ( 28933846 )
2017
6
Occupational exposure to extremely low-frequency magnetic fields and risk for central nervous system disease: an update of a Danish cohort study among utility workers. ( 28429106 )
2017
7
Is the Eye an Extension of the Brain in Central Nervous System Disease? ( 28609158 )
2017
8
Central Nervous System Disease in Antineutrophil Cytoplasmic Antibodies-Associated Vasculitis. ( 29061243 )
2017
9
Central nervous system disease in pediatric acute myeloid leukemia. ( 28853216 )
2017
10
Immunotherapeutics in Pediatric Autoimmune Central Nervous System Disease: Agents and Mechanisms. ( 29103429 )
2017
11
Metabolic Profiling of Central Nervous System Disease in Trypanosoma brucei rhodesiense infection. ( 28927234 )
2017
12
Production of transgenic pigs using the<i>pGFAP-CreER<sup>T2</sup>;EGFP<sup>LoxP</sup></i>inducible system for central nervous system disease models. ( 29284207 )
2017
13
Central Nervous System Disease, Education, and Race Impact Radiation Refusal in Pediatric Cancer Patients. ( 28538508 )
2017
14
Central nervous system disease in pediatric acute myeloid leukemia: A report from the Children's Oncology Group. ( 28453910 )
2017
15
Cerebrospinal fluid pleocytosis in infectious and noninfectious central nervous system disease: A retrospective cohort study. ( 28471963 )
2017
16
Wasp Venom Immunotherapy in a Patient With Immune-Mediated Inflammatory Central Nervous System Disease: Is it Safe? ( 28398199 )
2017
17
Editorial: Induction of Central Nervous System Disease by the Adaptive Immune Response. ( 29038655 )
2017
18
The function of NOD-like receptors in central nervous system diseases. ( 28029680 )
2017
19
Highly Expandable Human iPS Cell-Derived Neural Progenitor Cells (NPC) and Neurons for Central Nervous System Disease Modeling and High-Throughput Screening. ( 28075486 )
2017
20
Gpr124 is essential for blood-brain barrier integrity in central nervous system disease. ( 28288111 )
2017
21
Central nervous system disease and genital disease in harbor porpoises (Phocoena phocoena) are associated with different herpesviruses. ( 26861818 )
2016
22
Molecular Analysis of Central Nervous System Disease Spectrum in Childhood Acute Lymphoblastic Leukemia. ( 26997880 )
2016
23
Fatal Central Nervous System Disease Following First Infliximab Infusion in a Child With Inflammatory Bowel Disease. ( 26831951 )
2016
24
Clinical, electrophysiological, and biochemical markers of peripheral and central nervous system disease in canine globoid cell leukodystrophy (Krabbe'sA disease). ( 27638585 )
2016
25
Glial biomarkers in human central nervous system disease. ( 27228454 )
2016
26
Delivery of an adeno-associated virus vector into CSF attenuates central nervous system disease in mucopolysaccharidosis type II mice. ( 27510804 )
2016
27
The effects of diet on the severity of central nervous system disease: One part of lab-to-lab variability. ( 27133811 )
2016
28
AMP-Activated Protein Kinase Suppresses Autoimmune Central Nervous System Disease by Regulating M1-Type Macrophage-Th17 Axis. ( 27354217 )
2016
29
Hodgkin Lymphoma With Central Nervous System Disease at Primary Presentation. ( 26814676 )
2016
30
Raccoon Roundworm Infection Associated with Central Nervous System Disease and Ocular Disease - Six States, 2013-2015. ( 27608169 )
2016
31
Clinical and Laboratory Findings That Differentiate Herpes Simplex Virus Central Nervous System Disease from Enteroviral Meningitis. ( 27563314 )
2016
32
Central nervous system disease in childhood acute lymphoblastic leukaemia- a review. ( 26990196 )
2016
33
Macaque species susceptibility to simian immunodeficiency virus: increased incidence of SIV central nervous system disease in pigtailed macaques versus rhesus macaques. ( 25672885 )
2015
34
Evaluation of AAV-mediated Gene Therapy for Central Nervous System Disease in Canine Mucopolysaccharidosis VII. ( 26447927 )
2015
35
Targeted Temperature Management in Pediatric Central Nervous System Disease. ( 26042193 )
2015
36
Widespread correction of central nervous system disease after intracranial gene therapy in a feline model of Sandhoff disease. ( 25474439 )
2015
37
Flow cytometry for detection of central nervous system disease in acute myeloid leukemia. ( 25641427 )
2015
38
Intranasal delivery of stem cells as therapy for central nervous system disease. ( 25645932 )
2015
39
Systemic Therapy for HER2-Positive Central Nervous System Disease: Where We Are and Where Do We Go From Here? ( 26314739 )
2015
40
Interaction between Tat and Drugs of Abuse during HIV-1 Infection and Central Nervous System Disease. ( 26793168 )
2015
41
Diagnostic value of aquaporin 4 antibody in assessing idiopathic inflammatory demyelinating central nervous system diseases in Egyptian patients. ( 25677878 )
2015
42
Recurrent neonatal herpes simplex virus infection with central nervous system disease after completion of a 6-month course of suppressive therapy: Case report. ( 26390826 )
2015
43
A coumarin-based fluorescent probe as a central nervous system disease biomarker. ( 25390405 )
2014
44
RNA-sequencing reveals oligodendrocyte and neuronal transcripts in microglia relevant to central nervous system disease. ( 25258010 )
2014
45
Coxsackievirus-induced acute neonatal central nervous system disease model. ( 24696707 )
2014
46
Distinct systemic and central nervous system disease patterns in enterovirus and parechovirus infected children. ( 24662038 )
2014
47
Neonatal Herpes Simplex Virus Type-1 Central Nervous System Disease with Acute Retinal Necrosis. ( 24378951 )
2014
48
ELR(+) chemokine signaling in host defense and disease in a viral model of central nervous system disease. ( 24987333 )
2014
49
Current developments in understanding of West Nile virus central nervous system disease. ( 24722324 )
2014
50
HIV-Associated Central Nervous System Disease in Patients Admitted at the Douala General Hospital between 2004 and 2009: A Retrospective Study. ( 23533732 )
2013

Variations for Central Nervous System Disease

Expression for Central Nervous System Disease

Search GEO for disease gene expression data for Central Nervous System Disease.

Pathways for Central Nervous System Disease

GO Terms for Central Nervous System Disease

Cellular components related to Central Nervous System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.71 CCR1 CXCR3 MOG TRPV1
2 membrane raft GO:0045121 9.56 APP BACE1 PRNP PSEN1
3 endoplasmic reticulum GO:0005783 9.56 APOE BACE1 HTT MTDH PRNP PROM1
4 dendrite GO:0030425 9.55 APOE HTT PRNP PSEN1 TRPV1
5 amyloid-beta complex GO:0106003 9.37 APOE PRNP
6 ciliary rootlet GO:0035253 9.32 APP PSEN1
7 cell surface GO:0009986 9.1 APP BACE1 CXCR3 PRNP PROM1 PSEN1

Biological processes related to Central Nervous System Disease according to GeneCards Suite gene sharing:

(show all 37)
# Name GO ID Score Top Affiliating Genes
1 cell surface receptor signaling pathway GO:0007166 9.97 CCR1 CXCR3 IFNG TRPV1
2 cellular protein metabolic process GO:0044267 9.94 APOE APP BACE1 PSEN1
3 positive regulation of protein phosphorylation GO:0001934 9.9 APP IFNG IL1B PSEN1
4 cellular calcium ion homeostasis GO:0006874 9.85 APOE CCR1 PSEN1
5 inflammatory response GO:0006954 9.85 CCR1 CXCR3 IL1B NOS2 TLR9 TRPV1
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.84 APP IL1B MTDH TLR9
7 response to oxidative stress GO:0006979 9.83 APOE APP PRNP PSEN1
8 positive regulation of JNK cascade GO:0046330 9.82 APP IL1B TLR9
9 regulation of insulin secretion GO:0050796 9.8 IFNG IL1B NOS2
10 cellular response to drug GO:0035690 9.8 IL1B NOS2 PRNP
11 negative regulation of gene expression GO:0010629 9.8 APOE APP CCR1 IFNG NOS2
12 learning or memory GO:0007611 9.78 APP PRNP PSEN1
13 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.77 APP IL1B TLR9
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.75 IFNG IL1B TRPV1
15 cellular copper ion homeostasis GO:0006878 9.67 APP PRNP
16 amyloid-beta metabolic process GO:0050435 9.66 BACE1 PSEN1
17 positive regulation of protein import into nucleus, translocation GO:0033160 9.66 IFNG PSEN1
18 amyloid precursor protein metabolic process GO:0042982 9.65 APOE PSEN1
19 negative regulation of interleukin-17 production GO:0032700 9.65 IFNG PRNP
20 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.65 IL1B TLR9
21 negative regulation of amyloid-beta formation GO:1902430 9.63 APOE PRNP
22 cellular response to amyloid-beta GO:1904646 9.63 APP PRNP PSEN1
23 astrocyte activation GO:0048143 9.62 APP PSEN1
24 fever generation GO:0001660 9.58 IL1B TRPV1
25 regulation of epidermal growth factor-activated receptor activity GO:0007176 9.57 APP PSEN1
26 tumor necrosis factor production GO:0032640 9.56 APP TLR9
27 positive regulation of killing of cells of other organism GO:0051712 9.55 IFNG NOS2
28 astrocyte activation involved in immune response GO:0002265 9.51 APP PSEN1
29 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.5 APOE IFNG IL1B
30 negative regulation of low-density lipoprotein receptor activity GO:1905598 9.49 APP PSEN1
31 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.48 IFNG IL1B
32 smooth endoplasmic reticulum calcium ion homeostasis GO:0051563 9.43 APP PSEN1
33 negative regulation of long-term synaptic potentiation GO:1900272 9.43 APOE APP PRNP
34 modulation of age-related behavioral decline GO:0090647 9.33 APP PRNP PSEN1
35 neuron projection maintenance GO:1990535 9.13 APP PRNP PSEN1
36 positive regulation of amyloid fibril formation GO:1905908 8.8 APOE APP PSEN1
37 apoptotic process GO:0006915 10.09 APP CXCR3 HTT IFNG IL1B PSEN1

Molecular functions related to Central Nervous System Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 interleukin-1 receptor binding GO:0005149 8.96 IL1B TLR9
2 amyloid-beta binding GO:0001540 8.8 APOE BACE1 PRNP

Sources for Central Nervous System Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....