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MCID: CNT036
MIFTS: 38

Central Nervous System Germ Cell Tumor

Categories: Cancer diseases, Neuronal diseases
Genes Tissues Related diseases Publications Pathways Drugs
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Aliases & Classifications for Central Nervous System Germ Cell Tumor

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MalaCards integrated aliases for Central Nervous System Germ Cell Tumor:

Name: Central Nervous System Germ Cell Tumor 12 15 73
Germ Cell Tumor of the Cns 12

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:4439
NCIt 50 C5461
UMLS 73 C1332880
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Summaries for Central Nervous System Germ Cell Tumor

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MalaCards based summary : Central Nervous System Germ Cell Tumor, also known as germ cell tumor of the cns, is related to germ cells tumors and venous hemangioma. An important gene associated with Central Nervous System Germ Cell Tumor is POU5F1 (POU Class 5 Homeobox 1), and among its related pathways/superpathways are Neuroscience and Wnt / Hedgehog / Notch. The drugs Lenograstim and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include brain, bone and bone marrow, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

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Related Diseases for Central Nervous System Germ Cell Tumor

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Diseases in the Central Nervous System Germ Cell Tumor family:

Central Nervous System Adult Germ Cell Tumor

Diseases related to Central Nervous System Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 germ cells tumors 10.6
2 venous hemangioma 10.5 POU5F1 SOX2
3 non-functioning pancreatic endocrine tumor 10.4 POU5F1 SOX2
4 anaplastic ganglioglioma 10.4 GFAP NES
5 central nervous system primitive neuroectodermal neoplasm 10.4 GFAP NES
6 dysembryoplastic neuroepithelial tumor 10.4 GFAP NES
7 ependymoblastoma 10.4 GFAP NES
8 astroblastoma 10.4 GFAP NES
9 medulloepithelioma 10.3 GFAP NES
10 subependymoma 10.3 GFAP NES
11 tanycytic ependymoma 10.3 GFAP NES
12 papillary ependymoma 10.3 GFAP NES
13 gliomatosis cerebri 10.3 GFAP NES
14 brain ischemia 10.3 GFAP NES
15 subependymal giant cell astrocytoma 10.3 GFAP NES
16 central neurocytoma 10.3 GFAP NES
17 brain glioma 10.2 GFAP NES
18 suprasellar meningioma 10.2 GFAP POMC
19 retinitis pigmentosa 42 10.2 GFAP NES
20 optic nerve glioma 10.2 GFAP NES
21 cloacogenic carcinoma 10.2 POMC SOX2
22 infratentorial cancer 10.2 GFAP NES
23 ganglioglioma 10.2 GFAP NES
24 ocular cancer 10.1 POU5F1 SOX2
25 inappropriate adh syndrome 10.1 AVP POMC
26 neurilemmoma 10.1 GFAP NES
27 secondary hypertrophic osteoarthropathy 10.1 AVP POMC
28 extragonadal germ cell cancer 10.1 AFP POU5F1
29 embryonal testis carcinoma 10.1 AFP POU5F1
30 syndrome of inappropriate antidiuretic hormone 10.1 AVP POMC
31 central nervous system organ benign neoplasm 10.0 AVP POMC
32 ependymoma 10.0 GFAP NES
33 intratubular embryonal carcinoma 10.0 AFP POU5F1
34 malignant teratoma 10.0 AFP POU5F1
35 testicular infarct 10.0 AFP POU5F1
36 cervix small cell carcinoma 10.0 AVP POMC
37 mature teratoma 10.0 AFP POU5F1
38 diabetes insipidus, neurohypophyseal 10.0 AVP POMC
39 premenstrual tension 10.0 AVP POMC
40 chromophobe adenoma 10.0 AVP POMC
41 mixed germ cell cancer 10.0 AFP POU5F1
42 malignant leydig cell tumor 10.0 NES POMC POU5F1
43 pancreas disease 9.9 AVP POMC
44 melanotic medulloblastoma 9.9 AFP GFAP
45 central nervous system teratoma 9.9 GFAP NES SOX2
46 pituitary hormone deficiency, combined, 2 9.9 AVP POMC
47 testicular yolk sac tumor 9.8 AFP POU5F1
48 pituitary gland disease 9.8 AVP POMC
49 rh isoimmunization 9.8 AFP POMC
50 dysgerminoma of ovary 9.8 AFP GFAP

Graphical network of the top 20 diseases related to Central Nervous System Germ Cell Tumor:



Diseases related to Central Nervous System Germ Cell Tumor
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Symptoms & Phenotypes for Central Nervous System Germ Cell Tumor

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GenomeRNAi Phenotypes related to Central Nervous System Germ Cell Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.36 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.36 AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.36 POU5F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.36 POU5F1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.36 POU5F1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.36 POU5F1 AFP
7 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.36 AFP
8 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.36 POU5F1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.36 AFP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.36 POU5F1

MGI Mouse Phenotypes related to Central Nervous System Germ Cell Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.1 POU5F1 SOX2 AFP AVP GFAP POMC
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Drugs & Therapeutics for Central Nervous System Germ Cell Tumor

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Drugs for Central Nervous System Germ Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 209)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1 135968-09-1
2
Etoposide Approved Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
3
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
4
Carboplatin Approved Phase 3,Phase 2,Phase 1,Not Applicable 41575-94-4 10339178 498142 38904
5
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
6
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
7
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
8
Ofloxacin Approved Phase 3 82419-36-1 4583
9
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
10
Donepezil Approved Phase 3,Phase 2,Early Phase 1 120014-06-4 3152
11
Ondansetron Approved Phase 3 99614-02-5 4595
12
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
13
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
14 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
15 Dexamethasone acetate Phase 3,Phase 2,Phase 1 1177-87-3
16
Isophosphamide mustard Phase 3,Phase 2,Phase 1 0
17 Alkylating Agents Phase 3,Phase 2,Phase 1
18 Adjuvants, Immunologic Phase 3,Phase 1,Phase 2,Not Applicable
19 Gastrointestinal Agents Phase 3,Phase 2,Phase 1
20 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Not Applicable
21 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
22 Anti-Bacterial Agents Phase 3,Phase 1,Phase 2,Not Applicable
23 Etoposide phosphate Phase 3,Phase 2,Phase 1,Not Applicable
24 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
25 Anti-Infective Agents Phase 3,Phase 1,Phase 2
26 Antiemetics Phase 3,Phase 2
27 Protective Agents Phase 3,Phase 2,Phase 1,Not Applicable
28 Liver Extracts Phase 3,Phase 1,Phase 2
29 Antirheumatic Agents Phase 3,Phase 2,Phase 1
30 BB 1101 Phase 3,Phase 2,Phase 1
31 Autonomic Agents Phase 3,Phase 2
32 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
33 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1,Not Applicable
34 sodium thiosulfate Phase 3,Phase 1,Phase 2
35 Analgesics Phase 3,Phase 1
36 Renal Agents Phase 3
37 Central Nervous System Depressants Phase 3,Phase 1
38 Adjuvants, Anesthesia Phase 3
39 Chelating Agents Phase 3,Phase 1,Phase 2
40 Cholinergic Agents Phase 3,Phase 2,Early Phase 1
41 Cholinesterase Inhibitors Phase 3,Phase 2,Early Phase 1
42 Narcotics Phase 3
43 Neurotransmitter Agents Phase 3,Phase 2,Phase 1,Early Phase 1
44 Analgesics, Opioid Phase 3
45 Cytochrome P-450 CYP1A2 Inhibitors Phase 3
46 Cytochrome P-450 Enzyme Inhibitors Phase 3
47 Anesthetics Phase 3
48 Nootropic Agents Phase 3,Phase 2,Early Phase 1
49 Anesthetics, General Phase 3
50 Anesthetics, Intravenous Phase 3

Interventional clinical trials:

(show top 50) (show all 105)
# Name Status NCT ID Phase Drugs
1 Radiation Therapy Compared With Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Primary Central Nervous System (CNS) Germ Cell Tumor Completed NCT00085098 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
2 Combination Chemotherapy and Radiation Therapy in Treating Patients With Germ Cell Tumors in the Brain Completed NCT00293358 Phase 3 carboplatin;cisplatin;etoposide phosphate;ifosfamide
3 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
4 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
5 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
6 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
7 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3 levofloxacin
8 Chemotherapy, Surgery, Radiation Therapy and Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Primary CNS Germ Cell Tumors Unknown status NCT00025324 Phase 2 carboplatin;cyclophosphamide;etoposide;thiotepa
9 PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER Unknown status NCT01037790 Phase 2 PD-0332991
10 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
11 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
12 Combination Chemotherapy Followed by Bone Marrow and/or Peripheral Stem Cell Transplantation in Treating Patients With Recurrent Medulloblastoma or CNS Germ Cell Tumors Completed NCT00002594 Phase 2 cyclophosphamide;melphalan
13 Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment Completed NCT00091182 Phase 2 oxaliplatin
14 Irinotecan in Treating Children With Refractory Solid Tumors Completed NCT00004078 Phase 2 irinotecan hydrochloride
15 Cisplatin and Etoposide Prior to Radiation Therapy in Treating Patients With CNS Tumors Completed NCT00002472 Phase 2 cisplatin;etoposide
16 Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer Completed NCT00492089 Phase 2 bevacizumab;placebo
17 Chemotherapy and Vaccine Therapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation and Interleukin-2 in Treating Patients With Recurrent or Refractory Brain Cancer Completed NCT00014573 Phase 2 carmustine;cisplatin;cyclophosphamide;paclitaxel
18 High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors Completed NCT00003173 Phase 2 thiotepa
19 Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors Completed NCT00047320 Phase 2 carboplatin;etoposide;ifosfamide;thiotepa
20 Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor Completed NCT00070161 Phase 2 donepezil hydrochloride
21 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
22 Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
23 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
24 High-dose ICE With Amifostine Completed NCT00003657 Phase 2 Amifostine;Carboplatin;Etoposide;Ifosfamide
25 Chemotherapy Plus Peripheral Stem Cell Transplant in Treating Patients With Central Nervous System Cancer Completed NCT00007982 Phase 2 carmustine;cisplatin;cyclophosphamide;etoposide;thiotepa
26 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Tumors Completed NCT00003461 Phase 1, Phase 2
27 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
28 Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment Completed NCT00066248 Phase 2 cyproheptadine hydrochloride;megestrol acetate
29 Rebeccamycin Analogue in Treating Children With Solid Tumors or Non-Hodgkin's Lymphoma Completed NCT00006102 Phase 2 becatecarin
30 Temozolomide Plus Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Malignant Glioma or Recurrent CNS or Other Solid Tumors Completed NCT00005952 Phase 1, Phase 2 temozolomide
31 Gemcitabine, Paclitaxel and Oxaliplatin (GemPOx) Recruiting NCT01270724 Phase 2 Gemcitabine, Paclitaxel and Oxaliplatin (GemPOx).
32 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
33 Crizotinib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma Active, not recruiting NCT00939770 Phase 1, Phase 2 crizotinib
34 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
35 Temozolomide,Thiotepa and Carboplatin With Autologous Stem Cell Rescue Followed by 13-cis-retinoic Acid in Patients With Recurrent/Refractory Malignant Brain Tumors Active, not recruiting NCT00528437 Phase 2 temozolomide, thiotepa, carboplatin, 13-cis-retinoic acid
36 Chemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors Suspended NCT01602666 Phase 2 Carboplatin;Etoposide;Ifosfamide
37 Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors Suspended NCT00983398 Phase 1, Phase 2 Carboplatin;Mannitol;Melphalan;Sodium Thiosulfate
38 Imaging of Intravenous (IV) Combidex to Brain, Intra-cerebral Tumors and in Central Nervous System (CNS) Inflammation Terminated NCT00659334 Phase 2 Ferumoxtran-10 (Combidex)
39 Imatinib Mesylate With or Without Radiation Therapy in Treating Young Patients With Newly Diagnosed or Recurrent Glioma Terminated NCT00021229 Phase 1, Phase 2 imatinib mesylate
40 Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors Terminated NCT01808534 Phase 2 palifosfamide
41 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
42 Erlotinib Alone or in Combination With Radiation Therapy in Treating Young Patients With Refractory or Relapsed Malignant Brain Tumors or Newly Diagnosed Brain Stem Glioma Unknown status NCT00360854 Phase 1 erlotinib hydrochloride
43 Peripheral Stem Cell Transplantation Plus Chemotherapy in Treating Patients With Malignant Solid Tumors Unknown status NCT00007813 Phase 1 carboplatin;cyclophosphamide;etoposide
44 Stereotactic Radiosurgery in Treating Patients With Brain Tumors Completed NCT00019578 Phase 1
45 ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors Completed NCT00946335 Phase 1 veliparib;temozolomide
46 Cilengitide in Treating Children With Refractory Primary Brain Tumors Completed NCT00063973 Phase 1 cilengitide
47 Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors Completed NCT00052780 Phase 1 O6-benzylguanine;temozolomide
48 Ispinesib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Lymphoma Completed NCT00363272 Phase 1 ispinesib
49 AZD2171 in Treating Young Patients With Recurrent, Progressive, or Refractory Primary CNS Tumors Completed NCT00326664 Phase 1 Cediranib Maleate
50 Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma Completed NCT00994500 Phase 1 vorinostat;bortezomib

Search NIH Clinical Center for Central Nervous System Germ Cell Tumor

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Genetic Tests for Central Nervous System Germ Cell Tumor

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Anatomical Context for Central Nervous System Germ Cell Tumor

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MalaCards organs/tissues related to Central Nervous System Germ Cell Tumor:

41
Brain, Bone, Bone Marrow, Liver
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Publications for Central Nervous System Germ Cell Tumor

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Articles related to Central Nervous System Germ Cell Tumor:

(show all 22)
# Title Authors Year
1
Clinicopathological and immunohistochemical features of primary central nervous system germ cell tumors: a 24-years experience. ( 25400782 )
2014
2
Myeloablative chemotherapy and autologous stem cell transplantation in patients with relapsed or progressed central nervous system germ cell tumors: results of Korean Society of Pediatric Neuro-Oncology (KSPNO) S-053 study. ( 23824533 )
2013
3
Validation of tumor markers in central nervous system germ cell tumors by real-time reverse transcriptase polymerase chain reaction using formalin-fixed paraffin-embedded tissues. ( 23124437 )
2013
4
Memory disorders in children with central nervous system germ cell tumors. ( 22647728 )
2012
5
Longitudinal evaluation of neurocognitive function after treatment for central nervous system germ cell tumors in childhood. ( 21563173 )
2011
6
Proton radiotherapy for pediatric central nervous system germ cell tumors: early clinical outcomes. ( 20452141 )
2011
7
Intensity-modulated and 3D-conformal radiotherapy for whole-ventricular irradiation as compared with conventional whole-brain irradiation in the management of localized central nervous system germ cell tumors. ( 19879065 )
2010
8
Descriptive epidemiology of central nervous system germ cell tumors: nonpineal analysis. ( 20167813 )
2010
9
Surgical management of primary central nervous system germ cell tumors: proceedings from the Second International Symposium on Central Nervous System Germ Cell Tumors. ( 20672932 )
2010
10
Improved outcome of central nervous system germ cell tumors: implications for the role of risk-adapted intensive chemotherapy. ( 20191048 )
2010
11
Update on current standard treatments in central nervous system germ cell tumors. ( 20885323 )
2010
12
Pediatric primary central nervous system germ cell tumors of different prognosis groups show characteristic miRNome traits and chromosome copy number variations. ( 20178649 )
2010
13
The role of myeloablative chemotherapy with autologous hematopoietic cell rescue in central nervous system germ cell tumors. ( 20146220 )
2010
14
Isochromosome 12p and polysomy 12 in primary central nervous system germ cell tumors: frequency and association with clinicopathologic features. ( 19801160 )
2010
15
Central nervous system germ cell tumors: classification, clinical features, and treatment with a historical overview. ( 19841431 )
2009
16
Incidence patterns of central nervous system germ cell tumors: a SEER Study. ( 19636276 )
2009
17
[Treatment outcome of primary central nervous system germ cell tumors after combined therapy: a report of 23 cases]. ( 18423134 )
2008
18
Pediatric central nervous system germ cell tumors: a review. ( 18586924 )
2008
19
The prognostic value of tumor markers in newly diagnosed patients with primary central nervous system germ cell tumors. ( 18802946 )
2008
20
Nestin expression in central nervous system germ cell tumors. ( 18092184 )
2008
21
Podoplanin expression in primary central nervous system germ cell tumors: a useful histological marker for the diagnosis of germinoma. ( 16718353 )
2006
22
Chemotherapy without irradiation--a novel approach for newly diagnosed CNS germ cell tumors: results of an international cooperative trial. The First International Central Nervous System Germ Cell Tumor Study. ( 8918487 )
1996
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Variations for Central Nervous System Germ Cell Tumor

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Expression for Central Nervous System Germ Cell Tumor

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Search GEO for disease gene expression data for Central Nervous System Germ Cell Tumor.
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Pathways for Central Nervous System Germ Cell Tumor

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Pathways related to Central Nervous System Germ Cell Tumor according to GeneCards Suite gene sharing:

(show all 11)
# Super pathways Score Top Affiliating Genes
1
Neuroscience 4
12.14 AVP GFAP POMC
2
Wnt / Hedgehog / Notch 4
11.8 AFP POU5F1 SOX2
3
Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways 1
11.65 AVP POU5F1 SOX2
4
Glucocorticoid receptor regulatory network 1
11.41 AFP POMC
5
Preimplantation Embryo 1
11.26 POU5F1 SOX2
6
Cardiac Progenitor Differentiation 1
11.18 POU5F1 SOX2
7
Transcriptional regulation of pluripotent stem cells 66
Show member pathways
 11.09 POU5F1 SOX2
8
Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.05 AFP NES POU5F1 SOX2
9
Neural Stem Cell Differentiation Pathways and Lineage-specific Markers 65
11.03 GFAP NES SOX2
10
Oct4 in Mammalian ESC Pluripotency 64
10.55 POU5F1 SOX2
11
Human Early Embryo Development 64
Show member pathways
 10.16 POU5F1 SOX2
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GO Terms for Central Nervous System Germ Cell Tumor

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Cellular components related to Central Nervous System Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament cytoskeleton GO:0045111 8.62 GFAP NES

Biological processes related to Central Nervous System Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 somatic stem cell population maintenance GO:0035019 9.26 POU5F1 SOX2
2 generation of precursor metabolites and energy GO:0006091 9.16 AVP POMC
3 response to wounding GO:0009611 9.13 GFAP POU5F1 SOX2
4 endodermal cell fate specification GO:0001714 8.62 POU5F1 SOX2

Molecular functions related to Central Nervous System Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region sequence-specific DNA binding GO:0000976 9.16 POU5F1 SOX2
2 neuropeptide hormone activity GO:0005184 8.96 AVP POMC
3 miRNA binding GO:0035198 8.62 POU5F1 SOX2
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Sources for Central Nervous System Germ Cell Tumor

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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