MCID: CNT036
MIFTS: 36

Central Nervous System Germ Cell Tumor

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Germ Cell Tumor

MalaCards integrated aliases for Central Nervous System Germ Cell Tumor:

Name: Central Nervous System Germ Cell Tumor 12 15 74
Germ Cell Tumor of the Cns 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4439
NCIt 51 C5461
UMLS 74 C1332880

Summaries for Central Nervous System Germ Cell Tumor

Disease Ontology : 12 A central nervous system cancer that is characterized by tumors near the pineal gland, the pituitary gland and the tissue just above it, develops from mismigrational pluripotent embryonic cells that remain in the brain after birth, has material basis in abnormally proliferating cells derives from germ cells.

MalaCards based summary : Central Nervous System Germ Cell Tumor, also known as germ cell tumor of the cns, is related to childhood central nervous system mixed germ cell tumor and maturity-onset diabetes of the young, type 8, with exocrine dysfunction. An important gene associated with Central Nervous System Germ Cell Tumor is NES (Nestin), and among its related pathways/superpathways are Neuroscience and Wnt / Hedgehog / Notch. The drugs Carboplatin and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and bone, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Central Nervous System Germ Cell Tumor

Diseases in the Central Nervous System Germ Cell Tumor family:

Central Nervous System Adult Germ Cell Tumor

Diseases related to Central Nervous System Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 86)
# Related Disease Score Top Affiliating Genes
1 childhood central nervous system mixed germ cell tumor 11.3
2 maturity-onset diabetes of the young, type 8, with exocrine dysfunction 10.2 POU5F1 SOX2
3 nervous system cancer 10.2 GFAP NES
4 anaplastic ganglioglioma 10.2 GFAP NES
5 ganglioglioma 10.2 GFAP NES
6 venous hemangioma 10.2 POU5F1 SOX2
7 central nervous system primitive neuroectodermal neoplasm 10.2 GFAP NES
8 dysembryoplastic neuroepithelial tumor 10.2 GFAP NES
9 seminoma 10.2 AFP POU5F1
10 ependymoblastoma 10.2 GFAP NES
11 astroblastoma 10.2 GFAP NES
12 phosphoglycerate dehydrogenase deficiency 10.2 POU5F1 SOX2
13 extragonadal germ cell cancer 10.2 AFP POU5F1
14 embryonal testis carcinoma 10.2 AFP POU5F1
15 intratubular embryonal carcinoma 10.2 AFP POU5F1
16 non-functioning pancreatic endocrine tumor 10.2 POU5F1 SOX2
17 medulloepithelioma 10.2 GFAP NES
18 subependymoma 10.2 GFAP NES
19 ependymoma 10.2 GFAP NES
20 tanycytic ependymoma 10.2 GFAP NES
21 papillary ependymoma 10.2 GFAP NES
22 testicular infarct 10.2 AFP POU5F1
23 gliomatosis cerebri 10.2 GFAP NES
24 brain ischemia 10.2 GFAP NES
25 mature teratoma 10.2 AFP POU5F1
26 central neurocytoma 10.2 GFAP NES
27 embryoma 10.2 AFP POU5F1
28 subependymal giant cell astrocytoma 10.1 GFAP NES
29 mixed germ cell cancer 10.1 AFP POU5F1
30 melanotic medulloblastoma 10.1 AFP GFAP
31 mixed cell type cancer 10.1 AFP POU5F1
32 retinitis pigmentosa 42 10.1 GFAP NES
33 brain glioma 10.1 GFAP NES
34 optic nerve glioma 10.1 GFAP NES
35 infratentorial cancer 10.1 GFAP NES
36 oculomotor nerve paralysis 10.1 AFP AVP
37 third cranial nerve disease 10.1 AFP AVP
38 germinoma 10.0
39 germ cells tumors 10.0
40 testicular yolk sac tumor 10.0 AFP POU5F1
41 neurilemmoma 10.0 GFAP NES
42 dysgerminoma of ovary 10.0 AFP GFAP
43 ocular cancer 10.0 POU5F1 SOX2
44 supratentorial cancer 10.0 GFAP NES SOX2
45 cerebrum cancer 10.0 GFAP NES SOX2
46 tracheal cancer 10.0 AFP AVP
47 central nervous system cancer 10.0 GFAP NES SOX2
48 medulloblastoma 9.9 GFAP NES SOX2
49 ovarian embryonal carcinoma 9.9 AFP POU5F1 SOX2
50 pituitary carcinoma 9.9 GFAP POMC

Graphical network of the top 20 diseases related to Central Nervous System Germ Cell Tumor:



Diseases related to Central Nervous System Germ Cell Tumor

Symptoms & Phenotypes for Central Nervous System Germ Cell Tumor

GenomeRNAi Phenotypes related to Central Nervous System Germ Cell Tumor according to GeneCards Suite gene sharing:

27 (show all 11)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.4 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.4 AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.4 POU5F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.4 POU5F1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.4 POU5F1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.4 AFP POU5F1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.4 AFP
8 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.4 POU5F1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.4 AFP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-65 9.4 AFP
11 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.4 POU5F1

MGI Mouse Phenotypes related to Central Nervous System Germ Cell Tumor:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.1 AFP AVP GFAP POMC POU5F1 SOX2

Drugs & Therapeutics for Central Nervous System Germ Cell Tumor

Drugs for Central Nervous System Germ Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 222)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3,Phase 2,Phase 1,Not Applicable 41575-94-4 10339178 38904 498142
2
Etoposide Approved Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
3
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
4
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 2767 441203 84093
5
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1 135968-09-1
6
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
7
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
8
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 1177-87-3
9
Sargramostim Approved, Investigational Phase 3,Phase 2,Phase 1 123774-72-1, 83869-56-1
10
Ondansetron Approved Phase 3 99614-02-5 4595
11
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
12
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
13
Donepezil Approved Phase 3,Phase 2,Early Phase 1 120014-06-4 3152
14
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
15
Ofloxacin Approved Phase 3 82419-36-1 4583
16 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
17 Antirheumatic Agents Phase 3,Phase 2,Phase 1
18 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Not Applicable
19 Alkylating Agents Phase 3,Phase 2,Phase 1
20 Immunologic Factors Phase 3,Phase 2,Phase 1,Not Applicable
21 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
22 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1,Not Applicable
23 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
24 Etoposide phosphate Phase 3,Phase 2,Phase 1,Not Applicable
25 Adjuvants, Immunologic Phase 3,Phase 1,Phase 2,Not Applicable
26
Isophosphamide mustard Phase 3,Phase 2,Phase 1 0
27 Protective Agents Phase 3,Phase 2,Phase 1,Not Applicable
28 Anti-Infective Agents Phase 3,Phase 1,Phase 2
29 Anti-Bacterial Agents Phase 3,Phase 1,Phase 2,Not Applicable
30 Gastrointestinal Agents Phase 3,Phase 2,Phase 1
31 Antiemetics Phase 3,Phase 2
32 BB 1101 Phase 3,Phase 2,Phase 1
33 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
34 Autonomic Agents Phase 3,Phase 2
35 sodium thiosulfate Phase 3,Phase 1,Phase 2
36 Liver Extracts Phase 3,Phase 1,Phase 2
37 Antitubercular Agents Phase 3,Phase 1,Phase 2
38 Antioxidants Phase 3,Phase 1,Phase 2
39 Chelating Agents Phase 3,Phase 1,Phase 2
40 Antidotes Phase 3,Phase 1,Phase 2
41 Emetics Phase 3
42 Narcotics Phase 3
43 Adjuvants, Anesthesia Phase 3
44 Analgesics Phase 3,Phase 1
45 Anesthetics, Intravenous Phase 3
46 Anesthetics, General Phase 3
47 Anesthetics Phase 3
48 Analgesics, Opioid Phase 3
49 Central Nervous System Depressants Phase 3,Phase 1
50 Cola Phase 3,Phase 1

Interventional clinical trials:

(show top 50) (show all 104)
# Name Status NCT ID Phase Drugs
1 Radiation Therapy Compared With Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Primary Central Nervous System (CNS) Germ Cell Tumor Completed NCT00085098 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
2 Combination Chemotherapy and Radiation Therapy in Treating Patients With Germ Cell Tumors in the Brain Completed NCT00293358 Phase 3 carboplatin;cisplatin;etoposide phosphate;ifosfamide
3 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
4 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
5 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
6 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
7 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3 levofloxacin
8 Chemotherapy, Surgery, Radiation Therapy and Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Primary CNS Germ Cell Tumors Unknown status NCT00025324 Phase 2 carboplatin;cyclophosphamide;etoposide;thiotepa
9 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
10 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
11 Combination Chemotherapy Followed by Bone Marrow and/or Peripheral Stem Cell Transplantation in Treating Patients With Recurrent Medulloblastoma or CNS Germ Cell Tumors Completed NCT00002594 Phase 2 cyclophosphamide;melphalan
12 Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment Completed NCT00091182 Phase 2 oxaliplatin
13 Irinotecan in Treating Children With Refractory Solid Tumors Completed NCT00004078 Phase 2 irinotecan hydrochloride
14 Cisplatin and Etoposide Prior to Radiation Therapy in Treating Patients With CNS Tumors Completed NCT00002472 Phase 2 cisplatin;etoposide
15 Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer Completed NCT00492089 Phase 2 bevacizumab;placebo
16 Chemotherapy and Vaccine Therapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation and Interleukin-2 in Treating Patients With Recurrent or Refractory Brain Cancer Completed NCT00014573 Phase 2 carmustine;cisplatin;cyclophosphamide;paclitaxel
17 High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors Completed NCT00003173 Phase 2 thiotepa
18 Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors Completed NCT00047320 Phase 2 carboplatin;etoposide;ifosfamide;thiotepa
19 Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor Completed NCT00070161 Phase 2 donepezil hydrochloride
20 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
21 Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
22 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
23 High-dose ICE With Amifostine Completed NCT00003657 Phase 2 Amifostine;Carboplatin;Etoposide;Ifosfamide
24 Chemotherapy Plus Peripheral Stem Cell Transplant in Treating Patients With Central Nervous System Cancer Completed NCT00007982 Phase 2 carmustine;cisplatin;cyclophosphamide;etoposide;thiotepa
25 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Tumors Completed NCT00003461 Phase 1, Phase 2
26 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
27 Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment Completed NCT00066248 Phase 2 cyproheptadine hydrochloride;megestrol acetate
28 Rebeccamycin Analogue in Treating Children With Solid Tumors or Non-Hodgkin's Lymphoma Completed NCT00006102 Phase 2 becatecarin
29 Temozolomide Plus Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Malignant Glioma or Recurrent CNS or Other Solid Tumors Completed NCT00005952 Phase 1, Phase 2 temozolomide
30 Gemcitabine, Paclitaxel and Oxaliplatin (GemPOx) Recruiting NCT01270724 Phase 2 Gemcitabine, Paclitaxel and Oxaliplatin (GemPOx).
31 PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER Recruiting NCT01037790 Phase 2 PD-0332991
32 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
33 Chemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors Active, not recruiting NCT01602666 Phase 2 Carboplatin;Etoposide;Ifosfamide
34 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
35 Temozolomide,Thiotepa and Carboplatin With Autologous Stem Cell Rescue Followed by 13-cis-retinoic Acid in Patients With Recurrent/Refractory Malignant Brain Tumors Active, not recruiting NCT00528437 Phase 2 temozolomide, thiotepa, carboplatin, 13-cis-retinoic acid
36 Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors Suspended NCT00983398 Phase 1, Phase 2 Carboplatin;Mannitol;Melphalan;Sodium Thiosulfate
37 Imaging of Intravenous (IV) Combidex to Brain, Intra-cerebral Tumors and in Central Nervous System (CNS) Inflammation Terminated NCT00659334 Phase 2 Ferumoxtran-10 (Combidex)
38 Imatinib Mesylate With or Without Radiation Therapy in Treating Young Patients With Newly Diagnosed or Recurrent Glioma Terminated NCT00021229 Phase 1, Phase 2 imatinib mesylate
39 Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors Terminated NCT01808534 Phase 2 palifosfamide
40 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
41 Erlotinib Alone or in Combination With Radiation Therapy in Treating Young Patients With Refractory or Relapsed Malignant Brain Tumors or Newly Diagnosed Brain Stem Glioma Unknown status NCT00360854 Phase 1 erlotinib hydrochloride
42 Stereotactic Radiosurgery in Treating Patients With Brain Tumors Completed NCT00019578 Phase 1
43 ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors Completed NCT00946335 Phase 1 veliparib;temozolomide
44 Cilengitide in Treating Children With Refractory Primary Brain Tumors Completed NCT00063973 Phase 1 cilengitide
45 Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors Completed NCT00052780 Phase 1 O6-benzylguanine;temozolomide
46 Ispinesib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Lymphoma Completed NCT00363272 Phase 1 ispinesib
47 AZD2171 in Treating Young Patients With Recurrent, Progressive, or Refractory Primary CNS Tumors Completed NCT00326664 Phase 1 Cediranib Maleate
48 Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma Completed NCT00994500 Phase 1 vorinostat;bortezomib
49 Oxaliplatin and Irinotecan in Treating Young Patients With Refractory Solid Tumors or Lymphomas Completed NCT00101270 Phase 1 irinotecan hydrochloride;oxaliplatin
50 Lenalidomide in Treating Young Patients With Recurrent, Progressive, or Refractory CNS Tumors Completed NCT00100880 Phase 1 lenalidomide

Search NIH Clinical Center for Central Nervous System Germ Cell Tumor

Genetic Tests for Central Nervous System Germ Cell Tumor

Anatomical Context for Central Nervous System Germ Cell Tumor

MalaCards organs/tissues related to Central Nervous System Germ Cell Tumor:

42
Brain, Pituitary, Bone, Pineal, Bone Marrow, Liver, Lung

Publications for Central Nervous System Germ Cell Tumor

Articles related to Central Nervous System Germ Cell Tumor:

# Title Authors Year
1
Chemotherapy without irradiation--a novel approach for newly diagnosed CNS germ cell tumors: results of an international cooperative trial. The First International Central Nervous System Germ Cell Tumor Study. ( 8918487 )
1996

Variations for Central Nervous System Germ Cell Tumor

Expression for Central Nervous System Germ Cell Tumor

Search GEO for disease gene expression data for Central Nervous System Germ Cell Tumor.

Pathways for Central Nervous System Germ Cell Tumor

GO Terms for Central Nervous System Germ Cell Tumor

Cellular components related to Central Nervous System Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament cytoskeleton GO:0045111 8.62 GFAP NES

Biological processes related to Central Nervous System Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 somatic stem cell population maintenance GO:0035019 9.26 POU5F1 SOX2
2 generation of precursor metabolites and energy GO:0006091 9.16 AVP POMC
3 response to wounding GO:0009611 9.13 GFAP POU5F1 SOX2
4 endodermal cell fate specification GO:0001714 8.62 POU5F1 SOX2

Molecular functions related to Central Nervous System Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region sequence-specific DNA binding GO:0000976 8.96 POU5F1 SOX2
2 miRNA binding GO:0035198 8.62 POU5F1 SOX2

Sources for Central Nervous System Germ Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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