Central Nervous System Germ Cell Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CNT036 MIFTS: 26	Central Nervous System Germ Cell Tumor Categories: Cancer diseases, Neuronal diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
Genes Tissues Related diseases Publications Drugs Expand all tables

Sources

Aliases & Classifications for Central Nervous System Germ Cell Tumor

MalaCards integrated aliases for Central Nervous System Germ Cell Tumor:

Name: Central Nervous System Germ Cell Tumor ¹¹ ¹⁴ ⁷¹

Central Nervous System Germ Cell Tumour ¹¹

Germ Cell Tumour of the Cns ¹¹

Germ Cell Tumor of the Cns ¹¹

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:4439

NCIt ⁴⁹ C5461

UMLS ⁷¹ C1332880

Sources

Summaries for Central Nervous System Germ Cell Tumor

Disease Ontology: ¹¹ A central nervous system cancer that is characterized by tumors near the pineal gland, the pituitary gland and the tissue just above it, develops from mismigrational pluripotent embryonic cells that remain in the brain after birth, has material basis in abnormally proliferating cells derives from germ cells.

MalaCards based summary: Central Nervous System Germ Cell Tumor, also known as central nervous system germ cell tumour, is related to central nervous system neuroblastoma and childhood central nervous system mixed germ cell tumor. An important gene associated with Central Nervous System Germ Cell Tumor is FOXR2 (Forkhead Box R2). The drugs Bevacizumab and Irinotecan have been mentioned in the context of this disorder. Affiliated tissues include pineal, pituitary and brain.

Sources

Related Diseases for Central Nervous System Germ Cell Tumor

Diseases in the Central Nervous System Germ Cell Tumor family:

Central Nervous System Adult Germ Cell Tumor

Primary Germ Cell Tumor of Central Nervous System

Diseases related to Central Nervous System Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)

#	Related Disease	Score	Top Affiliating Genes
1	central nervous system neuroblastoma	28.8	SPHKAP PCP4L1 OLIG2 NXNL2 NUTM1 MYCN
2	childhood central nervous system mixed germ cell tumor	11.4
3	germ cell tumor	10.5
4	germinoma	10.5
5	germ cell cancer	10.3
6	brain cancer	10.3
7	astroblastoma, mn1-altered	10.2	MN1 BEND2
8	brain germinoma	10.2	PAGR1 AFP
9	central nervous system germinoma	10.2
10	anaplastic pleomorphic xanthoastrocytoma	10.1	OLIG2 MN1 BEND2
11	extragonadal nonseminomatous germ cell tumor	10.1	NUTM1 AFP
12	obstructive hydrocephalus	10.1	OLIG2 AFP
13	spinal ependymoma, mycn-amplified	10.1	OLIG2 MYCN
14	supratentorial primitive neuroectodermal tumor	10.1	MYCN FOXR2
15	mediastinal cancer	10.1	NUTM1 AFP
16	clear cell ependymoma	10.0	RELA OLIG2
17	posterior fossa ependymoma	10.0	RELA EZHIP
18	embryonal tumor with multilayered rosettes, c19mc-altered	10.0	MYCN MN1 FOXR2
19	medulloepithelioma	10.0	OLIG2 MYCN FOXR2
20	pineoblastoma	10.0	OLIG2 MYCN FOXR2
21	duodenal atresia	10.0	MYCN AFP
22	benign ependymoma	10.0	RELA OLIG2
23	spinal cord ependymoma	10.0	RELA MYCN
24	histone mutated tumor	9.9	OLIG2 MYCN
25	sweeney-cox syndrome	9.9	RELA MYCN
26	diffuse midline glioma, h3 k27m-mutant	9.9	OLIG2 MYCN
27	myxopapillary ependymoma	9.9	RELA MYCN MN1
28	supratentorial ependymoma	9.9	RELA MN1 EZHIP BEND2
29	tanycytic ependymoma	9.9	RELA OLIG2 MN1 BEND2
30	rela fusion-positive ependymoma	9.9	RELA OLIG2 MN1 BEND2
31	anaplastic ependymoma	9.9	RELA OLIG2 MN1 BEND2
32	pineal gland cancer	9.8	OLIG2 MYCN MN1 FOXR2 AFP
33	astroblastoma	9.8	RELA OLIG2 MN1 FOXR2 BEND2
34	hypersplenism	9.7	RELA AFP
35	atypical teratoid rhabdoid tumor	9.7	RELA OLIG2 MYCN FOXR2
36	cerebrum cancer	9.6	RELA OLIG2 MYCN MN1 EZHIP
37	supratentorial cancer	9.6	RELA OLIG2 MYCN MN1 EZHIP
38	high grade ependymoma	9.5	RELA OLIG2 MYCN MN1 EZHIP BEND2
39	cerebral ventricle cancer	9.5	RELA OLIG2 MYCN MN1 EZHIP BEND2
40	cns neuroblastoma with foxr2 activation	7.8	SPHKAP PCP4L1 OLIG2 NXNL2 NUTM1 MYCN

Graphical network of the top 20 diseases related to Central Nervous System Germ Cell Tumor:

Sources

Symptoms & Phenotypes for Central Nervous System Germ Cell Tumor

Sources

Drugs & Therapeutics for Central Nervous System Germ Cell Tumor

Drugs for Central Nervous System Germ Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 85)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Bevacizumab

Approved, Investigational

Phase 2

216974-75-3

135329020

Irinotecan

Approved, Investigational

Phase 2

97682-44-5, 100286-90-6

60838

Oxaliplatin

Approved, Investigational

Phase 2

61825-94-3

43805 11947679 6857599

Cisplatin

Approved

Phase 2

15663-27-1

2767 5702198 441203

Palbociclib

Approved, Investigational

Phase 2

571190-30-2

5330286

Lenograstim

Approved, Investigational

Phase 2

135968-09-1

Etoposide

Approved

Phase 2

33419-42-0

36462

Picropodophyllin

Approved, Investigational

Phase 2

518-28-5, 477-47-4

10607 72435

Thiotepa

Approved, Investigational

Phase 2

52-24-4

5453

Carboplatin

Approved

Phase 2

41575-94-4

10339178 38904

Levonorgestrel

Approved, Investigational

Phase 2

797-63-7

13109

Cyclophosphamide

Approved, Investigational

Phase 2

50-18-0, 6055-19-2

2907

Coenzyme M

Approved, Investigational

Phase 2

3375-50-6

598 23662354

Mechlorethamine

Approved, Investigational

Phase 2

51-75-2

4033

Ifosfamide

Approved

Phase 2

3778-73-2

3690

Lysine

Approved, Nutraceutical

Phase 2

56-87-1

5962

Palifosfamide

Investigational

Phase 2

31645-39-3

100427

topoisomerase I inhibitors

Phase 2

Angiogenesis Inhibitors

Phase 2

Protein Kinase Inhibitors

Phase 2

Antibodies, Monoclonal

Phase 2

Antineoplastic Agents, Immunological

Phase 2

Cyclin-Dependent Kinase Inhibitor Proteins

Phase 2

Adjuvants, Immunologic

Phase 2

Immunosuppressive Agents

Phase 2

Immunologic Factors

Phase 2

Protective Agents

Phase 2

Etoposide phosphate

Phase 2

16760419

Antimitotic Agents

Phase 2

Keratolytic Agents

Phase 2

Tubulin Modulators

Phase 2

Dermatologic Agents

Phase 2

Alkylating Agents

Phase 2

Antineoplastic Agents, Alkylating

Phase 2

Sunitinib

Approved, Investigational

Phase 1

557795-19-4

5329102

Vorinostat

Approved, Investigational

Phase 1

149647-78-9

5311

Bortezomib

Approved, Investigational

Phase 1

179324-69-7

387447 93860

Temozolomide

Approved, Investigational

Phase 1

85622-93-1

5394

Lenalidomide

Approved

Phase 1

191732-72-6

216326

Levoleucovorin

Approved, Experimental, Investigational

Phase 1

68538-85-2, 58-05-9, 73951-54-9

149436 6006

Fluorouracil

Approved

Phase 1

51-21-8

3385

Romidepsin

Approved, Investigational

Phase 1

128517-07-7

5352062

Fludarabine

Approved

Phase 1

75607-67-9, 21679-14-1

30751 657237

Mycophenolic acid

Approved, Investigational

Phase 1

24280-93-1

446541

Tacrolimus

Approved, Investigational

Phase 1

104987-11-3

6473866 445643

Busulfan

Approved, Investigational

Phase 1

55-98-1

2478

Melphalan

Approved

Phase 1

148-82-3

4053 460612

Topotecan

Approved, Investigational

Phase 1

123948-87-8, 119413-54-6

60699 60700

D-Tyrosine

Approved, Experimental, Investigational, Nutraceutical

Phase 1

133585-56-5, 60-18-4, 556-02-5

1153 6057

Folic acid

Approved, Nutraceutical, Vet_approved

Phase 1

59-30-3

6037

Interventional clinical trials:

(show all 24)

#	Name	Status	NCT ID	Phase	Drugs
1	A Randomized Phase II Trial of Bevacizumab to Control Brain Radiation Damage	Completed	NCT00492089	Phase 2	bevacizumab;placebo
2	Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer	Completed	NCT01037790	Phase 2	PD-0332991
3	A Phase II Study of Oxaliplatin in Children With Recurrent Solid Tumors	Completed	NCT00091182	Phase 2	oxaliplatin
4	Phase II Trial of Irinotecan in Children With Refractory Solid Tumors	Completed	NCT00004078	Phase 2	irinotecan hydrochloride
5	A Phase 2 Trial of Chemotherapy Followed by Response-Based Whole Ventricular &Amp; Spinal Canal Irradiation (WVSCI) for Patients With Localized Non-Germinomatous Central Nervous System Germ Cell Tumor	Recruiting	NCT04684368	Phase 2	Carboplatin;Etoposide;Ifosfamide;Mesna;Thiotepa
6	Multicenter Single Arm Phase II Study of Single Agent Palifosfamide in Recurrent and Incurable Germ Cell Tumors	Terminated	NCT01808534	Phase 2	palifosfamide
7	A Phase I Study of Sunitinib (SU11248), an Oral Multi-Targeted Tyrosine Kinase Inhibitor, in Children With Refractory Solid Tumors	Completed	NCT00387920	Phase 1	sunitinib malate
8	Phase I Pilot Study of Stereotaxic Radiosurgery in Patients With Intracranial Neoplasms	Completed	NCT00019578	Phase 1
9	A Phase I Study of Vorinostat and Bortezomib in Children With Refractory or Recurrent Solid Tumors, Including CNS Tumors and Lymphomas	Completed	NCT00994500	Phase 1	vorinostat;bortezomib
10	A Phase I Study of Oxaliplatin (NSC# 266046, IND #57004) and Irinotecan in Pediatric Patients With Refractory Solid Tumors and Lymphomas	Completed	NCT00101270	Phase 1	irinotecan hydrochloride;oxaliplatin
11	Phase I Trial of Temozolomide and O6-Benzylguanine in Pediatric Patients With Recurrent Brain Tumors	Completed	NCT00052780	Phase 1	O6-benzylguanine;temozolomide
12	A Phase I Trial of CC-5013 (Lenalidomide) in Pediatric Patients With Recurrent or Refractory Primary CNS Tumors	Completed	NCT00100880	Phase 1	lenalidomide
13	Phase I Study of Cilengitide (EMD 121974) in Children With Refractory Brain Tumors	Completed	NCT00063973	Phase 1	cilengitide
14	A Phase I Study of Pazopanib as a Single Agent for Children With Relapsed or Refractory Solid Tumors	Completed	NCT00929903	Phase 1	pazopanib hydrochloride
15	A PHASE 1 STUDY OF ISPINESIB (SB-715992) IN PEDIATRIC PATIENTS WITH RELAPSED OR REFRACTORY SOLID TUMORS	Completed	NCT00363272	Phase 1	ispinesib
16	A Phase I Clinical Trial of AZD2171 in Children With Recurrent or Progressive Central Nervous System (CNS) Tumors	Completed	NCT00326664	Phase 1	Cediranib Maleate
17	A Multi-Center Phase Ib Study of Oxaliplatin (NSC #266046) in Combination With Fluorouracil and Leucovorin in Pediatric Patients With Advanced Solid Tumors	Completed	NCT00281944	Phase 1	oxaliplatin;fluorouracil;leucovorin calcium
18	A Phase I Study of ABT-888, an Oral Inhibitor of Poly (ADP-Ribose) Polymerase and Temozolomide in Children With Recurrent/Refractory CNS Tumors	Completed	NCT00946335	Phase 1	veliparib;temozolomide
19	A PHASE I STUDY OF DEPSIPEPTIDE (NSC#630176, IND# 51810) IN PEDIATRIC PATIENTS WITH REFRACTORY SOLID TUMORS AND LEUKEMIAS	Completed	NCT00053963	Phase 1	romidepsin
20	A Pilot Study of Allogeneic Hematopoietic Cell Transplantation for Patients With High Grade Central Nervous System Malignancies	Recruiting	NCT04521946	Phase 1	Etoposide;Fludarabine Phosphate;Melphalan;Mycophenolate Mofetil;Tacrolimus;Thiotepa
21	Pilot Study of High-Dose Chemotherapy With Busulfan, Melphalan, and Topotecan Followed by Autologous Hematopoietic Stem Cell Transplant in Advanced Stage and Recurrent Tumors	Active, not recruiting	NCT00638898	Phase 1	busulfan;melphalan;topotecan hydrochloride
22	Microenvironment: Imaging/Implications in Brain Tumors; A Preliminary Investigation of the Biodistribution of [F-18]-EF5 in Patients With Brain Tumors	Terminated	NCT00110032	Phase 1	EF5
23	A Children's Oncology Group Protocol for Collecting and Banking Pediatric Brain Tumor Research Specimens	Completed	NCT00919750
24	Phase II Study of Proton Radiation Therapy for CNS Germ Cell Tumors: Evaluation of Acute and Late Side Effects	Active, not recruiting	NCT01049230

Search NIH Clinical Center for Central Nervous System Germ Cell Tumor

Sources

Genetic Tests for Central Nervous System Germ Cell Tumor

Sources

Anatomical Context for Central Nervous System Germ Cell Tumor

Organs/tissues related to Central Nervous System Germ Cell Tumor:

MalaCards : Pineal, Pituitary, Brain

Sources

Publications for Central Nervous System Germ Cell Tumor

Articles related to Central Nervous System Germ Cell Tumor:

(show all 12)

#	Title	Authors	PMID	Year
1	Roles of Tumor Markers in Central Nervous System Germ Cell Tumors Revisited with Histopathology-Proven Cases in a Large International Cohort. ⁶²	Takami H...Daniels DJ	35205726	2022
2	A Novel Germline SDHA Gene Mutation and Co-Occurring Somatic KIT Activating Mutation in a Patient With Pediatric Central Nervous System Germ Cell Tumor: Case Report. ⁶²	Yue X...Wang G	35651799	2022
3	Central nervous system germ cell tumor, an archetypal AYA tumor and a model for pediatric and neuro-oncology collaboration, review from the EURACAN domain 10 group. ⁶²	Faure Conter C...Frappaz D	36248981	2022
4	Detecting non-germinomatous germ cell tumor component by arterial spin labeling perfusion-weighted MR imaging in central nervous system germ cell tumor. ⁶²	Takano M...Yamasaki F	33460957	2021
5	Treatment outcome and long-term follow-up of central nervous system germ cell tumor using upfront chemotherapy with subsequent photon or proton radiation therapy: a single tertiary center experience of 127 patients. ⁶²	Hong KT...Shin HY	33036578	2020
6	Laser ablation-ICP-TOFMS imaging of germ cell tumors of patients undergoing platinum-based chemotherapy. ⁶²	Theiner S...Koellensperger G	32525499	2020
7	Cognitive Profile of Children With Intracranial Germ Cell Tumor According to Tumor Location. ⁶²	Coutinho V...Dufour C	29746441	2018
8	Treatment Outcome in Patients with Primary Central Nervous System Germ Cell Tumour: Clinical Experience from a Regional Cancer Centre in North India. ⁶²	Biswas A...Rath GK	28538229	2017
9	Highlights from the Third International Central Nervous System Germ Cell Tumour symposium: laying the foundations for future consensus. ⁶²	Murray MJ...Nicholson JC	23861728	2013
10	Reversible posterior leukoencephalopathy syndrome in Chinese children induced by chemotherapy: a review of five cases. ⁶²	Belaramani KM...Kwong NS	21282828	2011
11	Delayed surgical resection of central nervous system germ cell tumors. ⁶²	Weiner HL...Finlay JL	11904022	2002
12	Chemotherapy without irradiation--a novel approach for newly diagnosed CNS germ cell tumors: results of an international cooperative trial. The First International Central Nervous System Germ Cell Tumor Study. ⁶²	Balmaceda C...Finlay JL	8918487	1996

Sources

Genes for Central Nervous System Germ Cell Tumor

Genes related to Central Nervous System Germ Cell Tumor (0 elite genes):

(show all 17)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	FOXR2	Forkhead Box R2	Protein Coding	7.74	DISEASES inferred ¹⁴
2	MN1	MN1 Proto-Oncogene, Transcriptional Regulator	Protein Coding	7.62	DISEASES inferred ¹⁴
3	PAGR1	PAXIP1 Associated Glutamate Rich Protein 1	Protein Coding	7.22	DISEASES inferred ¹⁴ ¹⁴
4	BEND2	BEN Domain Containing 2	Protein Coding	5.87	DISEASES inferred ¹⁴
5	EZHIP	EZH Inhibitory Protein	Protein Coding	5.8	DISEASES inferred ¹⁴
6	NXNL2	Nucleoredoxin Like 2	Protein Coding	5.69	DISEASES inferred ¹⁴
7	OLIG2	Oligodendrocyte Transcription Factor 2	Protein Coding	5.67	DISEASES inferred ¹⁴
8	AFP	Alpha Fetoprotein	Protein Coding	5.66	DISEASES inferred ¹⁴
9	FOXR1	Forkhead Box R1	Protein Coding	5.62	DISEASES inferred ¹⁴
10	PCP4L1	Purkinje Cell Protein 4 Like 1	Protein Coding	5.59	DISEASES inferred ¹⁴
11	CNPY1	Canopy FGF Signaling Regulator 1	Protein Coding	5.4	DISEASES inferred ¹⁴
12	NUTM1	NUT Midline Carcinoma Family Member 1	Protein Coding	5.4	DISEASES inferred ¹⁴
13	MYCN	MYCN Proto-Oncogene, BHLH Transcription Factor	Protein Coding	5.16	DISEASES inferred ¹⁴
14	ELL3	Elongation Factor For RNA Polymerase II 3	Protein Coding	5.1	DISEASES inferred ¹⁴
15	ARHGAP36	Rho GTPase Activating Protein 36	Protein Coding	5.04	DISEASES inferred ¹⁴
16	SPHKAP	SPHK1 Interactor, AKAP Domain Containing	Protein Coding	4.99	DISEASES inferred ¹⁴
17	RELA	RELA Proto-Oncogene, NF-KB Subunit	Protein Coding	4.95	DISEASES inferred ¹⁴