MCID: CNT036
MIFTS: 26

Central Nervous System Germ Cell Tumor

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Central Nervous System Germ Cell Tumor

MalaCards integrated aliases for Central Nervous System Germ Cell Tumor:

Name: Central Nervous System Germ Cell Tumor 12 15 70
Central Nervous System Germ Cell Tumour 12
Germ Cell Tumour of the Cns 12
Germ Cell Tumor of the Cns 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4439
NCIt 50 C5461
UMLS 70 C1332880

Summaries for Central Nervous System Germ Cell Tumor

Disease Ontology : 12 A central nervous system cancer that is characterized by tumors near the pineal gland, the pituitary gland and the tissue just above it, develops from mismigrational pluripotent embryonic cells that remain in the brain after birth, has material basis in abnormally proliferating cells derives from germ cells.

MalaCards based summary : Central Nervous System Germ Cell Tumor, also known as central nervous system germ cell tumour, is related to germinoma and central nervous system neuroblastoma. An important gene associated with Central Nervous System Germ Cell Tumor is PAGR1 (PAXIP1 Associated Glutamate Rich Protein 1), and among its related pathways/superpathways is Transcriptional regulation of pluripotent stem cells. The drugs Oxaliplatin and Irinotecan have been mentioned in the context of this disorder. Affiliated tissues include pineal, pituitary and brain.

Related Diseases for Central Nervous System Germ Cell Tumor

Diseases in the Central Nervous System Germ Cell Tumor family:

Central Nervous System Adult Germ Cell Tumor Primary Germ Cell Tumor of Central Nervous System

Diseases related to Central Nervous System Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)
# Related Disease Score Top Affiliating Genes
1 germinoma 30.1 SALL4 POU5F1 PAGR1 AFP
2 central nervous system neuroblastoma 11.4
3 childhood central nervous system mixed germ cell tumor 11.4
4 germ cells tumors 10.4
5 endodermal sinus tumor 10.2 SALL4 AFP
6 extragonadal seminoma 10.2 SALL4 AFP
7 choriocarcinoma of the testis 10.2 SALL4 AFP
8 mixed germ cell cancer 10.1 SALL4 AFP
9 testicular malignant germ cell cancer 10.1 SALL4 AFP
10 dysgerminoma 10.1 SALL4 AFP
11 ovarian germ cell cancer 10.1 SALL4 AFP
12 pediatric testicular germ cell tumor 10.1 POU5F1 AFP
13 hepatoid adenocarcinoma 10.1 SALL4 AFP
14 ovarian embryonal carcinoma 10.1 POU5F1 AFP
15 intratubular embryonal carcinoma 10.1 POU5F1 AFP
16 dysgerminoma of ovary 10.0 POU5F1 AFP
17 ovarian gonadoblastoma 10.0 POU5F1 AFP
18 benign teratoma 10.0 SALL4 AFP
19 diencephalic astrocytoma 9.9 SALL4 POU5F1
20 pineoblastoma 9.9 POU5F1 AFP
21 diencephalic neoplasm 9.9 SALL4 POU5F1
22 ovarian primitive germ cell tumor 9.8 SALL4 POU5F1 AFP
23 ovarian endodermal sinus tumor 9.8 SALL4 POU5F1 AFP
24 duane-radial ray syndrome 9.8 SALL4 POU5F1
25 malignant teratoma 9.8 SALL4 POU5F1 AFP
26 mature teratoma 9.8 SALL4 POU5F1 AFP
27 spermatocytoma 9.8 SALL4 POU5F1 AFP
28 tyrosinemia 9.8 POU5F1 AFP
29 germ cell and embryonal cancer 9.8 SALL4 POU5F1 AFP
30 brain germinoma 9.8 POU5F1 PAGR1 CDIPTOSP AFP
31 germ cell cancer 9.8 SALL4 POU5F1 AFP
32 testicular disease 9.7 POU5F1 AFP
33 cryptorchidism, unilateral or bilateral 9.7 SALL4 POU5F1 AFP
34 chromosome 16p11.2 deletion syndrome 9.2 TLCD3B PAGR1 CDIPTOSP C16orf92 C16orf54 ASPHD1

Graphical network of the top 20 diseases related to Central Nervous System Germ Cell Tumor:



Diseases related to Central Nervous System Germ Cell Tumor

Symptoms & Phenotypes for Central Nervous System Germ Cell Tumor

Drugs & Therapeutics for Central Nervous System Germ Cell Tumor

Drugs for Central Nervous System Germ Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 5310940 9887054 6857599 43805
2
Irinotecan Approved, Investigational Phase 2 97682-44-5, 100286-90-6 60838
3
Lenograstim Approved, Investigational Phase 2 135968-09-1
4
Sargramostim Approved, Investigational Phase 2 123774-72-1, 83869-56-1
5
Mesna Approved, Investigational Phase 2 3375-50-6 598
6
Etoposide Approved Phase 2 33419-42-0 36462
7
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
8
Levonorgestrel Approved, Investigational Phase 2 797-63-7, 17489-40-6 13109
9
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
10
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
11
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
12
Ifosfamide Approved Phase 2 3778-73-2 3690
13
Lysine Approved, Nutraceutical Phase 2 56-87-1 5962
14 Antirheumatic Agents Phase 2
15 topoisomerase I inhibitors Phase 2
16 Tubulin Modulators Phase 2
17 Etoposide phosphate Phase 2
18 Adjuvants, Immunologic Phase 2
19 Antimitotic Agents Phase 2
20 Immunosuppressive Agents Phase 2
21 Protective Agents Phase 2
22 Dermatologic Agents Phase 2
23 Immunologic Factors Phase 2
24 Podophyllotoxin Phase 2 518-28-5
25 Keratolytic Agents Phase 2
26 Alkylating Agents Phase 2
27
Isophosphamide mustard Phase 2 100427
28
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
29 O(6)-benzylguanine Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Clinical Correlative Studies In Primary Central Nervous System Germ Cell Tumors: The Third International CNS Germ Cell Tumor Study Group Protocol Unknown status NCT00025324 Phase 2 carboplatin;cyclophosphamide;etoposide;thiotepa
2 A Phase II Study of Oxaliplatin in Children With Recurrent Solid Tumors Completed NCT00091182 Phase 2 oxaliplatin
3 Phase II Trial of Irinotecan in Children With Refractory Solid Tumors Completed NCT00004078 Phase 2 irinotecan hydrochloride
4 Phase 2 Trial of Response-Based Radiation Therapy for Patients With Localized Central Nervous System Germ Cell Tumors (CNS GCT) Active, not recruiting NCT01602666 Phase 2 Carboplatin;Etoposide;Ifosfamide
5 A Phase 2 Trial of Chemotherapy Followed by Response-Based Whole Ventricular &Amp; Spinal Canal Irradiation (WVSCI) for Patients With Localized Non-Germinomatous Central Nervous System Germ Cell Tumor Not yet recruiting NCT04684368 Phase 2 Carboplatin;Etoposide;Ifosfamide;Mesna;Thiotepa
6 Multicenter Single Arm Phase II Study of Single Agent Palifosfamide in Recurrent and Incurable Germ Cell Tumors Terminated NCT01808534 Phase 2 palifosfamide
7 Phase I Study of Cilengitide (EMD 121974) in Children With Refractory Brain Tumors Completed NCT00063973 Phase 1 cilengitide
8 Phase I Pilot Study of Stereotaxic Radiosurgery in Patients With Intracranial Neoplasms Completed NCT00019578 Phase 1
9 Phase I Trial of Temozolomide and O6-Benzylguanine in Pediatric Patients With Recurrent Brain Tumors Completed NCT00052780 Phase 1 O6-benzylguanine;temozolomide

Search NIH Clinical Center for Central Nervous System Germ Cell Tumor

Genetic Tests for Central Nervous System Germ Cell Tumor

Anatomical Context for Central Nervous System Germ Cell Tumor

MalaCards organs/tissues related to Central Nervous System Germ Cell Tumor:

40
Pineal, Pituitary, Brain, Ovary, Testis

Publications for Central Nervous System Germ Cell Tumor

Articles related to Central Nervous System Germ Cell Tumor:

# Title Authors PMID Year
1
Detecting non-germinomatous germ cell tumor component by arterial spin labeling perfusion-weighted MR imaging in central nervous system germ cell tumor. 61
33460957 2021
2
Treatment outcome and long-term follow-up of central nervous system germ cell tumor using upfront chemotherapy with subsequent photon or proton radiation therapy: a single tertiary center experience of 127 patients. 61
33036578 2020
3
Laser ablation-ICP-TOFMS imaging of germ cell tumors of patients undergoing platinum-based chemotherapy. 61
32525499 2020
4
Cognitive Profile of Children With Intracranial Germ Cell Tumor According to Tumor Location. 61
29746441 2018
5
Delayed surgical resection of central nervous system germ cell tumors. 61
11904022 2002
6
Chemotherapy without irradiation--a novel approach for newly diagnosed CNS germ cell tumors: results of an international cooperative trial. The First International Central Nervous System Germ Cell Tumor Study. 61
8918487 1996

Variations for Central Nervous System Germ Cell Tumor

Expression for Central Nervous System Germ Cell Tumor

Search GEO for disease gene expression data for Central Nervous System Germ Cell Tumor.

Pathways for Central Nervous System Germ Cell Tumor

Pathways related to Central Nervous System Germ Cell Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.31 SALL4 POU5F1

GO Terms for Central Nervous System Germ Cell Tumor

Biological processes related to Central Nervous System Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 somatic stem cell population maintenance GO:0035019 8.62 SALL4 POU5F1

Sources for Central Nervous System Germ Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
Content
Loading form....