MCID: CNT036
MIFTS: 36

Central Nervous System Germ Cell Tumor

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Germ Cell Tumor

MalaCards integrated aliases for Central Nervous System Germ Cell Tumor:

Name: Central Nervous System Germ Cell Tumor 12 15 73
Germ Cell Tumor of the Cns 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4439
NCIt 50 C5461
UMLS 73 C1332880

Summaries for Central Nervous System Germ Cell Tumor

Disease Ontology : 12 A central nervous system cancer that is characterized by tumors near the pineal gland, the pituitary gland and the tissue just above it, develops from mismigrational pluripotent embryonic cells that remain in the brain after birth, has material basis in abnormally proliferating cells derives from germ cells.

MalaCards based summary : Central Nervous System Germ Cell Tumor, also known as germ cell tumor of the cns, is related to childhood central nervous system mixed germ cell tumor and maturity-onset diabetes of the young, type 8, with exocrine dysfunction. An important gene associated with Central Nervous System Germ Cell Tumor is NES (Nestin), and among its related pathways/superpathways are Neuroscience and Wnt / Hedgehog / Notch. The drugs Carboplatin and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include brain, pituitary and pineal, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Central Nervous System Germ Cell Tumor

Diseases in the Central Nervous System Germ Cell Tumor family:

Central Nervous System Adult Germ Cell Tumor

Diseases related to Central Nervous System Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 83)
# Related Disease Score Top Affiliating Genes
1 childhood central nervous system mixed germ cell tumor 11.3
2 maturity-onset diabetes of the young, type 8, with exocrine dysfunction 10.1 POU5F1 SOX2
3 nervous system cancer 10.1 GFAP NES
4 anaplastic ganglioglioma 10.1 GFAP NES
5 ganglioglioma 10.1 GFAP NES
6 venous hemangioma 10.1 POU5F1 SOX2
7 central nervous system primitive neuroectodermal neoplasm 10.1 GFAP NES
8 dysembryoplastic neuroepithelial tumor 10.1 GFAP NES
9 ependymoblastoma 10.1 GFAP NES
10 astroblastoma 10.1 GFAP NES
11 phosphoglycerate dehydrogenase deficiency 10.1 POU5F1 SOX2
12 non-functioning pancreatic endocrine tumor 10.1 POU5F1 SOX2
13 medulloepithelioma 10.1 GFAP NES
14 subependymoma 10.1 GFAP NES
15 ependymoma 10.1 GFAP NES
16 tanycytic ependymoma 10.1 GFAP NES
17 papillary ependymoma 10.1 GFAP NES
18 gliomatosis cerebri 10.1 GFAP NES
19 brain ischemia 10.1 GFAP NES
20 central neurocytoma 10.1 GFAP NES
21 subependymal giant cell astrocytoma 10.1 GFAP NES
22 suprasellar meningioma 10.1 GFAP POMC
23 retinitis pigmentosa 42 10.1 GFAP NES
24 brain glioma 10.1 GFAP NES
25 cloacogenic carcinoma 10.1 POMC SOX2
26 optic nerve glioma 10.1 GFAP NES
27 lung oat cell carcinoma 10.0 AVP POMC
28 germ cells tumors 10.0
29 bronchus cancer 10.0 AVP POMC
30 inappropriate adh syndrome 10.0 AVP POMC
31 olfactory nerve neoplasm 10.0 AVP POMC
32 secondary hypertrophic osteoarthropathy 10.0 AVP POMC
33 neurilemmoma 10.0 GFAP NES
34 seminoma 10.0 AFP POU5F1
35 syndrome of inappropriate antidiuretic hormone 10.0 AVP POMC
36 ocular cancer 10.0 POU5F1 SOX2
37 extragonadal germ cell cancer 10.0 AFP POU5F1
38 embryonal testis carcinoma 10.0 AFP POU5F1
39 intratubular embryonal carcinoma 10.0 AFP POU5F1
40 cervix small cell carcinoma 10.0 AVP POMC
41 diabetes insipidus, neurohypophyseal 10.0 AVP POMC
42 diabetes insipidus 10.0 AVP POMC
43 testicular infarct 10.0 AFP POU5F1
44 mature teratoma 10.0 AFP POU5F1
45 malignant leydig cell tumor 10.0 NES POMC POU5F1
46 embryoma 10.0 AFP POU5F1
47 cranial nerve malignant neoplasm 10.0 AVP POMC
48 premenstrual tension 10.0 AVP POMC
49 chromophobe adenoma 10.0 AVP POMC
50 mixed germ cell cancer 10.0 AFP POU5F1

Graphical network of the top 20 diseases related to Central Nervous System Germ Cell Tumor:



Diseases related to Central Nervous System Germ Cell Tumor

Symptoms & Phenotypes for Central Nervous System Germ Cell Tumor

GenomeRNAi Phenotypes related to Central Nervous System Germ Cell Tumor according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.36 AFP
2 Increased shRNA abundance (Z-score > 2) GR00366-A-120 9.36 AFP
3 Increased shRNA abundance (Z-score > 2) GR00366-A-123 9.36 POU5F1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-127 9.36 POU5F1
5 Increased shRNA abundance (Z-score > 2) GR00366-A-149 9.36 POU5F1
6 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.36 AFP POU5F1
7 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.36 AFP
8 Increased shRNA abundance (Z-score > 2) GR00366-A-32 9.36 POU5F1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.36 AFP
10 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.36 POU5F1

MGI Mouse Phenotypes related to Central Nervous System Germ Cell Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.1 AFP AVP GFAP POMC POU5F1 SOX2

Drugs & Therapeutics for Central Nervous System Germ Cell Tumor

Drugs for Central Nervous System Germ Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 213)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3,Phase 2,Phase 1,Not Applicable 41575-94-4 10339178 38904 498142
2
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 6055-19-2, 50-18-0 2907
3
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 2767 441203 84093
4
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1 135968-09-1
5
Etoposide Approved Phase 3,Phase 2,Phase 1,Not Applicable 33419-42-0 36462
6
Ifosfamide Approved Phase 3,Phase 2,Phase 1 3778-73-2 3690
7
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 1177-87-3
8
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 2,Phase 1 50-02-2 5743
9
Ondansetron Approved Phase 3 99614-02-5 4595
10
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
11
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 3 437-38-7 3345
12
Donepezil Approved Phase 3,Phase 2,Early Phase 1 120014-06-4 3152
13
Levofloxacin Approved, Investigational Phase 3 100986-85-4 149096
14
Ofloxacin Approved Phase 3 82419-36-1 4583
15 Pancreatic Polypeptide Investigational Phase 3,Phase 1 59763-91-6
16 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1,Not Applicable
17 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
18 Adjuvants, Immunologic Phase 3,Phase 1,Phase 2,Not Applicable
19 Immunologic Factors Phase 3,Phase 2,Phase 1,Not Applicable
20 Alkylating Agents Phase 3,Phase 2,Phase 1
21 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
22 Etoposide phosphate Phase 3,Phase 2,Phase 1,Not Applicable
23 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1,Not Applicable
24 Antirheumatic Agents Phase 3,Phase 2,Phase 1
25
Isophosphamide mustard Phase 3,Phase 2,Phase 1 0
26 Anti-Infective Agents Phase 3,Phase 1,Phase 2
27 Liver Extracts Phase 3,Phase 1,Phase 2
28 Anti-Bacterial Agents Phase 3,Phase 1,Phase 2,Not Applicable
29 Protective Agents Phase 3,Phase 2,Phase 1,Not Applicable
30 Gastrointestinal Agents Phase 3,Phase 2,Phase 1
31 Antiemetics Phase 3,Phase 2
32 Autonomic Agents Phase 3,Phase 2
33 BB 1101 Phase 3,Phase 2,Phase 1
34 Peripheral Nervous System Agents Phase 3,Phase 2,Phase 1
35 sodium thiosulfate Phase 3,Phase 1,Phase 2
36 Antioxidants Phase 3,Phase 1,Phase 2
37 Antitubercular Agents Phase 3,Phase 1,Phase 2
38 Chelating Agents Phase 3,Phase 1,Phase 2
39 Antidotes Phase 3,Phase 1,Phase 2
40 Emetics Phase 3
41 Cola Phase 3,Phase 1
42 Central Nervous System Depressants Phase 3,Phase 1
43 Adjuvants, Anesthesia Phase 3
44 Anesthetics, Intravenous Phase 3
45 Analgesics, Opioid Phase 3
46 Anesthetics, General Phase 3
47 Analgesics Phase 3,Phase 1
48 Narcotics Phase 3
49 Anesthetics Phase 3
50 Neurotransmitter Agents Phase 3,Phase 2,Phase 1,Early Phase 1

Interventional clinical trials:

(show top 50) (show all 104)
# Name Status NCT ID Phase Drugs
1 Radiation Therapy Compared With Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Primary Central Nervous System (CNS) Germ Cell Tumor Completed NCT00085098 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
2 Combination Chemotherapy and Radiation Therapy in Treating Patients With Germ Cell Tumors in the Brain Completed NCT00293358 Phase 3 carboplatin;cisplatin;etoposide phosphate;ifosfamide
3 Sodium Thiosulfate in Preventing Hearing Loss in Young Patients Receiving Cisplatin for Newly Diagnosed Germ Cell Tumor, Hepatoblastoma, Medulloblastoma, Neuroblastoma, Osteosarcoma, or Other Malignancy Completed NCT00716976 Phase 3 sodium thiosulfate
4 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
5 Fentanyl Sublingual Spray in Treating Patients With Breakthrough Cancer Pain Completed NCT00538850 Phase 3 Fentanyl sublingual spray;Placebo
6 Donepezil in Treating Patients Who Have Undergone Radiation Therapy for Brain Tumors Completed NCT00369785 Phase 3 donepezil hydrochloride;Placebo
7 Levofloxacin to Prevent Infection Following Chemotherapy in Treating Patients With Solid Tumors or Lymphoma Completed NCT00005590 Phase 3 levofloxacin
8 Chemotherapy, Surgery, Radiation Therapy and Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Primary CNS Germ Cell Tumors Unknown status NCT00025324 Phase 2 carboplatin;cyclophosphamide;etoposide;thiotepa
9 High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy Unknown status NCT01172912 Phase 2 carboplatin;cisplatin;dexamethasone;etoposide;ifosfamide
10 Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors Unknown status NCT00551122 Phase 1, Phase 2 cisplatin;gemcitabine hydrochloride;ifosfamide;paclitaxel
11 Combination Chemotherapy Followed by Bone Marrow and/or Peripheral Stem Cell Transplantation in Treating Patients With Recurrent Medulloblastoma or CNS Germ Cell Tumors Completed NCT00002594 Phase 2 cyclophosphamide;melphalan
12 Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment Completed NCT00091182 Phase 2 oxaliplatin
13 Irinotecan in Treating Children With Refractory Solid Tumors Completed NCT00004078 Phase 2 irinotecan hydrochloride
14 Cisplatin and Etoposide Prior to Radiation Therapy in Treating Patients With CNS Tumors Completed NCT00002472 Phase 2 cisplatin;etoposide
15 Bevacizumab in Reducing CNS Side Effects in Patients Who Have Undergone Radiation Therapy to the Brain for Primary Brain Tumor, Meningioma, or Head and Neck Cancer Completed NCT00492089 Phase 2 bevacizumab;placebo
16 Chemotherapy and Vaccine Therapy Followed by Bone Marrow or Peripheral Stem Cell Transplantation and Interleukin-2 in Treating Patients With Recurrent or Refractory Brain Cancer Completed NCT00014573 Phase 2 carmustine;cisplatin;cyclophosphamide;paclitaxel
17 High-Dose Thiotepa Plus Peripheral Stem Cell Transplantation in Treating Patients With Refractory Solid Tumors Completed NCT00003173 Phase 2 thiotepa
18 Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors Completed NCT00047320 Phase 2 carboplatin;etoposide;ifosfamide;thiotepa
19 Phase II Studies Of Donepezil And Ginkgo Biloba In Irradiated Brain Tumor Completed NCT00070161 Phase 2 donepezil hydrochloride
20 Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors Completed NCT00070096 Phase 2 ixabepilone
21 Paclitaxel, Ifosfamide, and Carboplatin Followed By Autologous Stem Cell Transplant in Treating Patients With Germ Cell Tumors That Did Not Respond to Cisplatin Completed NCT00423852 Phase 1, Phase 2 carboplatin;ifosfamide;paclitaxel
22 Combination Chemotherapy and Pegfilgrastim in Treating Patients With Previously Untreated Germ Cell Tumors Completed NCT00470366 Phase 2 cisplatin;ifosfamide;paclitaxel
23 High-dose ICE With Amifostine Completed NCT00003657 Phase 2 Amifostine;Carboplatin;Etoposide;Ifosfamide
24 Chemotherapy Plus Peripheral Stem Cell Transplant in Treating Patients With Central Nervous System Cancer Completed NCT00007982 Phase 2 carmustine;cisplatin;cyclophosphamide;etoposide;thiotepa
25 Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Primary or Metastatic Brain Tumors Completed NCT00003461 Phase 1, Phase 2
26 Combination Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Patients With Relapsed Germ Cell Cancer Completed NCT00002931 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel
27 Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment Completed NCT00066248 Phase 2 cyproheptadine hydrochloride;megestrol acetate
28 Rebeccamycin Analogue in Treating Children With Solid Tumors or Non-Hodgkin's Lymphoma Completed NCT00006102 Phase 2 becatecarin
29 Temozolomide Plus Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Malignant Glioma or Recurrent CNS or Other Solid Tumors Completed NCT00005952 Phase 1, Phase 2 temozolomide
30 Gemcitabine, Paclitaxel and Oxaliplatin (GemPOx) Recruiting NCT01270724 Phase 2 Gemcitabine, Paclitaxel and Oxaliplatin (GemPOx).
31 PHASE II TRIAL OF THE CYCLIN-DEPEDENT KINASE INHIBITOR PD 0332991 IN PATIENTS WITH CANCER Recruiting NCT01037790 Phase 2 PD-0332991
32 Autologous Peripheral Blood Stem Cell Transplant for Germ Cell Tumors Recruiting NCT00432094 Phase 2 carboplatin;etoposide;ifosfamide;paclitaxel;thiotepa;Mesna
33 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
34 Temozolomide,Thiotepa and Carboplatin With Autologous Stem Cell Rescue Followed by 13-cis-retinoic Acid in Patients With Recurrent/Refractory Malignant Brain Tumors Active, not recruiting NCT00528437 Phase 2 temozolomide, thiotepa, carboplatin, 13-cis-retinoic acid
35 Chemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors Suspended NCT01602666 Phase 2 Carboplatin;Etoposide;Ifosfamide
36 Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors Suspended NCT00983398 Phase 1, Phase 2 Carboplatin;Mannitol;Melphalan;Sodium Thiosulfate
37 Imaging of Intravenous (IV) Combidex to Brain, Intra-cerebral Tumors and in Central Nervous System (CNS) Inflammation Terminated NCT00659334 Phase 2 Ferumoxtran-10 (Combidex)
38 Imatinib Mesylate With or Without Radiation Therapy in Treating Young Patients With Newly Diagnosed or Recurrent Glioma Terminated NCT00021229 Phase 1, Phase 2 imatinib mesylate
39 Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors Terminated NCT01808534 Phase 2 palifosfamide
40 Photodynamic Therapy With Porfimer Sodium in Treating Patients With Refractory Brain Tumors Unknown status NCT00002647 Phase 1 verteporfin
41 Erlotinib Alone or in Combination With Radiation Therapy in Treating Young Patients With Refractory or Relapsed Malignant Brain Tumors or Newly Diagnosed Brain Stem Glioma Unknown status NCT00360854 Phase 1 erlotinib hydrochloride
42 Peripheral Stem Cell Transplantation Plus Chemotherapy in Treating Patients With Malignant Solid Tumors Unknown status NCT00007813 Phase 1 carboplatin;cyclophosphamide;etoposide
43 Stereotactic Radiosurgery in Treating Patients With Brain Tumors Completed NCT00019578 Phase 1
44 ABT-888 and Temozolomide in Treating Young Patients With Recurrent or Refractory CNS Tumors Completed NCT00946335 Phase 1 veliparib;temozolomide
45 Cilengitide in Treating Children With Refractory Primary Brain Tumors Completed NCT00063973 Phase 1 cilengitide
46 Temozolomide and O6-Benzylguanine in Treating Children With Recurrent Brain Tumors Completed NCT00052780 Phase 1 O6-benzylguanine;temozolomide
47 Ispinesib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Lymphoma Completed NCT00363272 Phase 1 ispinesib
48 AZD2171 in Treating Young Patients With Recurrent, Progressive, or Refractory Primary CNS Tumors Completed NCT00326664 Phase 1 Cediranib Maleate
49 Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma Completed NCT00994500 Phase 1 vorinostat;bortezomib
50 Oxaliplatin and Irinotecan in Treating Young Patients With Refractory Solid Tumors or Lymphomas Completed NCT00101270 Phase 1 irinotecan hydrochloride;oxaliplatin

Search NIH Clinical Center for Central Nervous System Germ Cell Tumor

Genetic Tests for Central Nervous System Germ Cell Tumor

Anatomical Context for Central Nervous System Germ Cell Tumor

MalaCards organs/tissues related to Central Nervous System Germ Cell Tumor:

41
Brain, Pituitary, Pineal, Bone, Liver, Bone Marrow, Lung

Publications for Central Nervous System Germ Cell Tumor

Articles related to Central Nervous System Germ Cell Tumor:

# Title Authors Year
1
Chemotherapy without irradiation--a novel approach for newly diagnosed CNS germ cell tumors: results of an international cooperative trial. The First International Central Nervous System Germ Cell Tumor Study. ( 8918487 )
1996

Variations for Central Nervous System Germ Cell Tumor

Expression for Central Nervous System Germ Cell Tumor

Search GEO for disease gene expression data for Central Nervous System Germ Cell Tumor.

Pathways for Central Nervous System Germ Cell Tumor

GO Terms for Central Nervous System Germ Cell Tumor

Cellular components related to Central Nervous System Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament cytoskeleton GO:0045111 8.62 GFAP NES

Biological processes related to Central Nervous System Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 somatic stem cell population maintenance GO:0035019 9.26 POU5F1 SOX2
2 generation of precursor metabolites and energy GO:0006091 9.16 AVP POMC
3 response to wounding GO:0009611 9.13 GFAP POU5F1 SOX2
4 endodermal cell fate specification GO:0001714 8.62 POU5F1 SOX2

Molecular functions related to Central Nervous System Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transcription regulatory region sequence-specific DNA binding GO:0000976 8.96 POU5F1 SOX2
2 miRNA binding GO:0035198 8.62 POU5F1 SOX2

Sources for Central Nervous System Germ Cell Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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