Central Nervous System Germ Cell Tumor disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CNT036 MIFTS: 26	Central Nervous System Germ Cell Tumor Categories: Cancer diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for Central Nervous System Germ Cell Tumor

MalaCards integrated aliases for Central Nervous System Germ Cell Tumor:

Name: Central Nervous System Germ Cell Tumor ¹² ¹⁵ ⁷⁰

Central Nervous System Germ Cell Tumour ¹²

Germ Cell Tumour of the Cns ¹²

Germ Cell Tumor of the Cns ¹²

Classifications:

MalaCards categories:
Global: Cancer diseases Rare diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:4439

NCIt ⁵⁰ C5461

UMLS ⁷⁰ C1332880

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Summaries for Central Nervous System Germ Cell Tumor

Disease Ontology : ¹² A central nervous system cancer that is characterized by tumors near the pineal gland, the pituitary gland and the tissue just above it, develops from mismigrational pluripotent embryonic cells that remain in the brain after birth, has material basis in abnormally proliferating cells derives from germ cells.

MalaCards based summary : Central Nervous System Germ Cell Tumor, also known as central nervous system germ cell tumour, is related to germinoma and central nervous system neuroblastoma. An important gene associated with Central Nervous System Germ Cell Tumor is PAGR1 (PAXIP1 Associated Glutamate Rich Protein 1), and among its related pathways/superpathways is Transcriptional regulation of pluripotent stem cells. The drugs Oxaliplatin and Irinotecan have been mentioned in the context of this disorder. Affiliated tissues include pineal, pituitary and brain.

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Related Diseases for Central Nervous System Germ Cell Tumor

Diseases in the Central Nervous System Germ Cell Tumor family:

Central Nervous System Adult Germ Cell Tumor

Primary Germ Cell Tumor of Central Nervous System

Diseases related to Central Nervous System Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 34)

#	Related Disease	Score	Top Affiliating Genes
1	germinoma	30.1	SALL4 POU5F1 PAGR1 AFP
2	central nervous system neuroblastoma	11.4
3	childhood central nervous system mixed germ cell tumor	11.4
4	germ cells tumors	10.4
5	endodermal sinus tumor	10.2	SALL4 AFP
6	extragonadal seminoma	10.2	SALL4 AFP
7	choriocarcinoma of the testis	10.2	SALL4 AFP
8	mixed germ cell cancer	10.1	SALL4 AFP
9	testicular malignant germ cell cancer	10.1	SALL4 AFP
10	dysgerminoma	10.1	SALL4 AFP
11	ovarian germ cell cancer	10.1	SALL4 AFP
12	pediatric testicular germ cell tumor	10.1	POU5F1 AFP
13	hepatoid adenocarcinoma	10.1	SALL4 AFP
14	ovarian embryonal carcinoma	10.1	POU5F1 AFP
15	intratubular embryonal carcinoma	10.1	POU5F1 AFP
16	dysgerminoma of ovary	10.0	POU5F1 AFP
17	ovarian gonadoblastoma	10.0	POU5F1 AFP
18	benign teratoma	10.0	SALL4 AFP
19	diencephalic astrocytoma	9.9	SALL4 POU5F1
20	pineoblastoma	9.9	POU5F1 AFP
21	diencephalic neoplasm	9.9	SALL4 POU5F1
22	ovarian primitive germ cell tumor	9.8	SALL4 POU5F1 AFP
23	ovarian endodermal sinus tumor	9.8	SALL4 POU5F1 AFP
24	duane-radial ray syndrome	9.8	SALL4 POU5F1
25	malignant teratoma	9.8	SALL4 POU5F1 AFP
26	mature teratoma	9.8	SALL4 POU5F1 AFP
27	spermatocytoma	9.8	SALL4 POU5F1 AFP
28	tyrosinemia	9.8	POU5F1 AFP
29	germ cell and embryonal cancer	9.8	SALL4 POU5F1 AFP
30	brain germinoma	9.8	POU5F1 PAGR1 CDIPTOSP AFP
31	germ cell cancer	9.8	SALL4 POU5F1 AFP
32	testicular disease	9.7	POU5F1 AFP
33	cryptorchidism, unilateral or bilateral	9.7	SALL4 POU5F1 AFP
34	chromosome 16p11.2 deletion syndrome	9.2	TLCD3B PAGR1 CDIPTOSP C16orf92 C16orf54 ASPHD1

Graphical network of the top 20 diseases related to Central Nervous System Germ Cell Tumor:

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Symptoms & Phenotypes for Central Nervous System Germ Cell Tumor

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Drugs & Therapeutics for Central Nervous System Germ Cell Tumor

Drugs for Central Nervous System Germ Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 29)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Oxaliplatin

Approved, Investigational

Phase 2

61825-94-3

5310940 9887054 6857599 43805

Irinotecan

Approved, Investigational

Phase 2

97682-44-5, 100286-90-6

60838

Lenograstim

Approved, Investigational

Phase 2

135968-09-1

Sargramostim

Approved, Investigational

Phase 2

123774-72-1, 83869-56-1

Mesna

Approved, Investigational

Phase 2

3375-50-6

598

Etoposide

Approved

Phase 2

33419-42-0

36462

Cyclophosphamide

Approved, Investigational

Phase 2

50-18-0, 6055-19-2

2907

Levonorgestrel

Approved, Investigational

Phase 2

797-63-7, 17489-40-6

13109

Thiotepa

Approved, Investigational

Phase 2

52-24-4

5453

Carboplatin

Approved

Phase 2

41575-94-4

10339178 498142 38904

Mechlorethamine

Approved, Investigational

Phase 2

51-75-2

4033

Ifosfamide

Approved

Phase 2

3778-73-2

3690

Lysine

Approved, Nutraceutical

Phase 2

56-87-1

5962

Antirheumatic Agents

Phase 2

topoisomerase I inhibitors

Phase 2

Tubulin Modulators

Phase 2

Etoposide phosphate

Phase 2

Adjuvants, Immunologic

Phase 2

Antimitotic Agents

Phase 2

Immunosuppressive Agents

Phase 2

Protective Agents

Phase 2

Dermatologic Agents

Phase 2

Immunologic Factors

Phase 2

Podophyllotoxin

Phase 2

518-28-5

Keratolytic Agents

Phase 2

Alkylating Agents

Phase 2

Isophosphamide mustard

Phase 2

100427

Temozolomide

Approved, Investigational

Phase 1

85622-93-1

5394

O(6)-benzylguanine

Phase 1

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Clinical Correlative Studies In Primary Central Nervous System Germ Cell Tumors: The Third International CNS Germ Cell Tumor Study Group Protocol	Unknown status	NCT00025324	Phase 2	carboplatin;cyclophosphamide;etoposide;thiotepa
2	A Phase II Study of Oxaliplatin in Children With Recurrent Solid Tumors	Completed	NCT00091182	Phase 2	oxaliplatin
3	Phase II Trial of Irinotecan in Children With Refractory Solid Tumors	Completed	NCT00004078	Phase 2	irinotecan hydrochloride
4	Phase 2 Trial of Response-Based Radiation Therapy for Patients With Localized Central Nervous System Germ Cell Tumors (CNS GCT)	Active, not recruiting	NCT01602666	Phase 2	Carboplatin;Etoposide;Ifosfamide
5	A Phase 2 Trial of Chemotherapy Followed by Response-Based Whole Ventricular &Amp; Spinal Canal Irradiation (WVSCI) for Patients With Localized Non-Germinomatous Central Nervous System Germ Cell Tumor	Not yet recruiting	NCT04684368	Phase 2	Carboplatin;Etoposide;Ifosfamide;Mesna;Thiotepa
6	Multicenter Single Arm Phase II Study of Single Agent Palifosfamide in Recurrent and Incurable Germ Cell Tumors	Terminated	NCT01808534	Phase 2	palifosfamide
7	Phase I Study of Cilengitide (EMD 121974) in Children With Refractory Brain Tumors	Completed	NCT00063973	Phase 1	cilengitide
8	Phase I Pilot Study of Stereotaxic Radiosurgery in Patients With Intracranial Neoplasms	Completed	NCT00019578	Phase 1
9	Phase I Trial of Temozolomide and O6-Benzylguanine in Pediatric Patients With Recurrent Brain Tumors	Completed	NCT00052780	Phase 1	O6-benzylguanine;temozolomide

Search NIH Clinical Center for Central Nervous System Germ Cell Tumor

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Genetic Tests for Central Nervous System Germ Cell Tumor

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Anatomical Context for Central Nervous System Germ Cell Tumor

MalaCards organs/tissues related to Central Nervous System Germ Cell Tumor:

⁴⁰

Pineal, Pituitary, Brain, Ovary, Testis

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Publications for Central Nervous System Germ Cell Tumor

Articles related to Central Nervous System Germ Cell Tumor:

#	Title	Authors	PMID	Year
1	Detecting non-germinomatous germ cell tumor component by arterial spin labeling perfusion-weighted MR imaging in central nervous system germ cell tumor. ⁶¹	Takano M...Yamasaki F	33460957	2021
2	Treatment outcome and long-term follow-up of central nervous system germ cell tumor using upfront chemotherapy with subsequent photon or proton radiation therapy: a single tertiary center experience of 127 patients. ⁶¹	Hong KT...Shin HY	33036578	2020
3	Laser ablation-ICP-TOFMS imaging of germ cell tumors of patients undergoing platinum-based chemotherapy. ⁶¹	Theiner S...Koellensperger G	32525499	2020
4	Cognitive Profile of Children With Intracranial Germ Cell Tumor According to Tumor Location. ⁶¹	Coutinho V...Dufour C	29746441	2018
5	Delayed surgical resection of central nervous system germ cell tumors. ⁶¹	Weiner HL...Finlay JL	11904022	2002
6	Chemotherapy without irradiation--a novel approach for newly diagnosed CNS germ cell tumors: results of an international cooperative trial. The First International Central Nervous System Germ Cell Tumor Study. ⁶¹	Balmaceda C...Finlay JL	8918487	1996

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Genes for Central Nervous System Germ Cell Tumor

Genes related to Central Nervous System Germ Cell Tumor (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PAGR1	PAXIP1 Associated Glutamate Rich Protein 1	Protein Coding	9.66	DISEASES inferred ¹⁵ ¹⁵
2	AFP	Alpha Fetoprotein	Protein Coding	6.2	DISEASES inferred ¹⁵
3	CDIPTOSP	CDIP Transferase Opposite Strand, Pseudogene	RNA Gene	6.02	DISEASES inferred ¹⁵
4	C16orf92	Chromosome 16 Open Reading Frame 92	Protein Coding	5.49	DISEASES inferred ¹⁵
5	AUNIP	Aurora Kinase A And Ninein Interacting Protein	Protein Coding	5.44	DISEASES inferred ¹⁵
6	CEP85	Centrosomal Protein 85	Protein Coding	5.41	DISEASES inferred ¹⁵
7	C16orf54	Chromosome 16 Open Reading Frame 54	Protein Coding	5.37	DISEASES inferred ¹⁵
8	ZNF593	Zinc Finger Protein 593	Protein Coding	5.35	DISEASES inferred ¹⁵
9	SALL4	Spalt Like Transcription Factor 4	Protein Coding	5.28	DISEASES inferred ¹⁵
10	C6orf136	Chromosome 6 Open Reading Frame 136	Protein Coding	5.18	DISEASES inferred ¹⁵
11	POU5F1	POU Class 5 Homeobox 1	Protein Coding	5.18	DISEASES inferred ¹⁵
12	ASPHD1	Aspartate Beta-Hydroxylase Domain Containing 1	Protein Coding	5.12	DISEASES inferred ¹⁵
13	TLCD3B	TLC Domain Containing 3B	Protein Coding	5.11	DISEASES inferred ¹⁵

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Variations for Central Nervous System Germ Cell Tumor

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Expression for Central Nervous System Germ Cell Tumor

Search GEO for disease gene expression data for Central Nervous System Germ Cell Tumor.

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Pathways for Central Nervous System Germ Cell Tumor

Pathways related to Central Nervous System Germ Cell Tumor according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Transcriptional regulation of pluripotent stem cells ⁶⁵ Show member pathways POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation ⁶⁵	10.31	SALL4 POU5F1

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GO Terms for Central Nervous System Germ Cell Tumor

Biological processes related to Central Nervous System Germ Cell Tumor according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	somatic stem cell population maintenance	GO:0035019	8.62	SALL4 POU5F1

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Sources for Central Nervous System Germ Cell Tumor

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia