MCID: CNT036
MIFTS: 26

Central Nervous System Germ Cell Tumor

Categories: Cancer diseases, Neuronal diseases, Rare diseases
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Aliases & Classifications for Central Nervous System Germ Cell Tumor

MalaCards integrated aliases for Central Nervous System Germ Cell Tumor:

Name: Central Nervous System Germ Cell Tumor 11 14 71
Central Nervous System Germ Cell Tumour 11
Germ Cell Tumour of the Cns 11
Germ Cell Tumor of the Cns 11

Classifications:



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Disease Ontology 11 DOID:4439
NCIt 49 C5461
UMLS 71 C1332880

Summaries for Central Nervous System Germ Cell Tumor

Disease Ontology: 11 A central nervous system cancer that is characterized by tumors near the pineal gland, the pituitary gland and the tissue just above it, develops from mismigrational pluripotent embryonic cells that remain in the brain after birth, has material basis in abnormally proliferating cells derives from germ cells.

MalaCards based summary: Central Nervous System Germ Cell Tumor, also known as central nervous system germ cell tumour, is related to central nervous system neuroblastoma and childhood central nervous system mixed germ cell tumor. An important gene associated with Central Nervous System Germ Cell Tumor is FOXR2 (Forkhead Box R2). The drugs Bevacizumab and Irinotecan have been mentioned in the context of this disorder. Affiliated tissues include pineal, pituitary and brain.

Related Diseases for Central Nervous System Germ Cell Tumor

Diseases in the Central Nervous System Germ Cell Tumor family:

Central Nervous System Adult Germ Cell Tumor Primary Germ Cell Tumor of Central Nervous System

Diseases related to Central Nervous System Germ Cell Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 central nervous system neuroblastoma 28.8 SPHKAP PCP4L1 OLIG2 NXNL2 NUTM1 MYCN
2 childhood central nervous system mixed germ cell tumor 11.4
3 germ cell tumor 10.5
4 germinoma 10.5
5 germ cell cancer 10.3
6 brain cancer 10.3
7 astroblastoma, mn1-altered 10.2 MN1 BEND2
8 brain germinoma 10.2 PAGR1 AFP
9 central nervous system germinoma 10.2
10 anaplastic pleomorphic xanthoastrocytoma 10.1 OLIG2 MN1 BEND2
11 extragonadal nonseminomatous germ cell tumor 10.1 NUTM1 AFP
12 obstructive hydrocephalus 10.1 OLIG2 AFP
13 spinal ependymoma, mycn-amplified 10.1 OLIG2 MYCN
14 supratentorial primitive neuroectodermal tumor 10.1 MYCN FOXR2
15 mediastinal cancer 10.1 NUTM1 AFP
16 clear cell ependymoma 10.0 RELA OLIG2
17 posterior fossa ependymoma 10.0 RELA EZHIP
18 embryonal tumor with multilayered rosettes, c19mc-altered 10.0 MYCN MN1 FOXR2
19 medulloepithelioma 10.0 OLIG2 MYCN FOXR2
20 pineoblastoma 10.0 OLIG2 MYCN FOXR2
21 duodenal atresia 10.0 MYCN AFP
22 benign ependymoma 10.0 RELA OLIG2
23 spinal cord ependymoma 10.0 RELA MYCN
24 histone mutated tumor 9.9 OLIG2 MYCN
25 sweeney-cox syndrome 9.9 RELA MYCN
26 diffuse midline glioma, h3 k27m-mutant 9.9 OLIG2 MYCN
27 myxopapillary ependymoma 9.9 RELA MYCN MN1
28 supratentorial ependymoma 9.9 RELA MN1 EZHIP BEND2
29 tanycytic ependymoma 9.9 RELA OLIG2 MN1 BEND2
30 rela fusion-positive ependymoma 9.9 RELA OLIG2 MN1 BEND2
31 anaplastic ependymoma 9.9 RELA OLIG2 MN1 BEND2
32 pineal gland cancer 9.8 OLIG2 MYCN MN1 FOXR2 AFP
33 astroblastoma 9.8 RELA OLIG2 MN1 FOXR2 BEND2
34 hypersplenism 9.7 RELA AFP
35 atypical teratoid rhabdoid tumor 9.7 RELA OLIG2 MYCN FOXR2
36 cerebrum cancer 9.6 RELA OLIG2 MYCN MN1 EZHIP
37 supratentorial cancer 9.6 RELA OLIG2 MYCN MN1 EZHIP
38 high grade ependymoma 9.5 RELA OLIG2 MYCN MN1 EZHIP BEND2
39 cerebral ventricle cancer 9.5 RELA OLIG2 MYCN MN1 EZHIP BEND2
40 cns neuroblastoma with foxr2 activation 7.8 SPHKAP PCP4L1 OLIG2 NXNL2 NUTM1 MYCN

Graphical network of the top 20 diseases related to Central Nervous System Germ Cell Tumor:



Diseases related to Central Nervous System Germ Cell Tumor

Symptoms & Phenotypes for Central Nervous System Germ Cell Tumor

Drugs & Therapeutics for Central Nervous System Germ Cell Tumor

Drugs for Central Nervous System Germ Cell Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 85)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bevacizumab Approved, Investigational Phase 2 216974-75-3 135329020
2
Irinotecan Approved, Investigational Phase 2 97682-44-5, 100286-90-6 60838
3
Oxaliplatin Approved, Investigational Phase 2 61825-94-3 43805 11947679 6857599
4
Cisplatin Approved Phase 2 15663-27-1 2767 5702198 441203
5
Palbociclib Approved, Investigational Phase 2 571190-30-2 5330286
6
Lenograstim Approved, Investigational Phase 2 135968-09-1
7
Etoposide Approved Phase 2 33419-42-0 36462
8
Picropodophyllin Approved, Investigational Phase 2 518-28-5, 477-47-4 10607 72435
9
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
10
Carboplatin Approved Phase 2 41575-94-4 10339178 38904
11
Levonorgestrel Approved, Investigational Phase 2 797-63-7 13109
12
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
13
Coenzyme M Approved, Investigational Phase 2 3375-50-6 598 23662354
14
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
15
Ifosfamide Approved Phase 2 3778-73-2 3690
16
Lysine Approved, Nutraceutical Phase 2 56-87-1 5962
17
Palifosfamide Investigational Phase 2 31645-39-3 100427
18 topoisomerase I inhibitors Phase 2
19 Angiogenesis Inhibitors Phase 2
20 Protein Kinase Inhibitors Phase 2
21 Antibodies, Monoclonal Phase 2
22 Antineoplastic Agents, Immunological Phase 2
23 Cyclin-Dependent Kinase Inhibitor Proteins Phase 2
24 Adjuvants, Immunologic Phase 2
25 Immunosuppressive Agents Phase 2
26 Immunologic Factors Phase 2
27 Protective Agents Phase 2
28
Etoposide phosphate Phase 2 16760419
29 Antimitotic Agents Phase 2
30 Keratolytic Agents Phase 2
31 Tubulin Modulators Phase 2
32 Dermatologic Agents Phase 2
33 Alkylating Agents Phase 2
34 Antineoplastic Agents, Alkylating Phase 2
35
Sunitinib Approved, Investigational Phase 1 557795-19-4 5329102
36
Vorinostat Approved, Investigational Phase 1 149647-78-9 5311
37
Bortezomib Approved, Investigational Phase 1 179324-69-7 387447 93860
38
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
39
Lenalidomide Approved Phase 1 191732-72-6 216326
40
Levoleucovorin Approved, Experimental, Investigational Phase 1 68538-85-2, 58-05-9, 73951-54-9 149436 6006
41
Fluorouracil Approved Phase 1 51-21-8 3385
42
Romidepsin Approved, Investigational Phase 1 128517-07-7 5352062
43
Fludarabine Approved Phase 1 75607-67-9, 21679-14-1 30751 657237
44
Mycophenolic acid Approved, Investigational Phase 1 24280-93-1 446541
45
Tacrolimus Approved, Investigational Phase 1 104987-11-3 6473866 445643
46
Busulfan Approved, Investigational Phase 1 55-98-1 2478
47
Melphalan Approved Phase 1 148-82-3 4053 460612
48
Topotecan Approved, Investigational Phase 1 123948-87-8, 119413-54-6 60699 60700
49
D-Tyrosine Approved, Experimental, Investigational, Nutraceutical Phase 1 133585-56-5, 60-18-4, 556-02-5 1153 6057
50
Folic acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037

Interventional clinical trials:

(show all 24)
# Name Status NCT ID Phase Drugs
1 A Randomized Phase II Trial of Bevacizumab to Control Brain Radiation Damage Completed NCT00492089 Phase 2 bevacizumab;placebo
2 Phase II Trial of the Cyclin-Dependent Kinase Inhibitor PD 0332991 in Patients With Cancer Completed NCT01037790 Phase 2 PD-0332991
3 A Phase II Study of Oxaliplatin in Children With Recurrent Solid Tumors Completed NCT00091182 Phase 2 oxaliplatin
4 Phase II Trial of Irinotecan in Children With Refractory Solid Tumors Completed NCT00004078 Phase 2 irinotecan hydrochloride
5 A Phase 2 Trial of Chemotherapy Followed by Response-Based Whole Ventricular &Amp; Spinal Canal Irradiation (WVSCI) for Patients With Localized Non-Germinomatous Central Nervous System Germ Cell Tumor Recruiting NCT04684368 Phase 2 Carboplatin;Etoposide;Ifosfamide;Mesna;Thiotepa
6 Multicenter Single Arm Phase II Study of Single Agent Palifosfamide in Recurrent and Incurable Germ Cell Tumors Terminated NCT01808534 Phase 2 palifosfamide
7 A Phase I Study of Sunitinib (SU11248), an Oral Multi-Targeted Tyrosine Kinase Inhibitor, in Children With Refractory Solid Tumors Completed NCT00387920 Phase 1 sunitinib malate
8 Phase I Pilot Study of Stereotaxic Radiosurgery in Patients With Intracranial Neoplasms Completed NCT00019578 Phase 1
9 A Phase I Study of Vorinostat and Bortezomib in Children With Refractory or Recurrent Solid Tumors, Including CNS Tumors and Lymphomas Completed NCT00994500 Phase 1 vorinostat;bortezomib
10 A Phase I Study of Oxaliplatin (NSC# 266046, IND #57004) and Irinotecan in Pediatric Patients With Refractory Solid Tumors and Lymphomas Completed NCT00101270 Phase 1 irinotecan hydrochloride;oxaliplatin
11 Phase I Trial of Temozolomide and O6-Benzylguanine in Pediatric Patients With Recurrent Brain Tumors Completed NCT00052780 Phase 1 O6-benzylguanine;temozolomide
12 A Phase I Trial of CC-5013 (Lenalidomide) in Pediatric Patients With Recurrent or Refractory Primary CNS Tumors Completed NCT00100880 Phase 1 lenalidomide
13 Phase I Study of Cilengitide (EMD 121974) in Children With Refractory Brain Tumors Completed NCT00063973 Phase 1 cilengitide
14 A Phase I Study of Pazopanib as a Single Agent for Children With Relapsed or Refractory Solid Tumors Completed NCT00929903 Phase 1 pazopanib hydrochloride
15 A PHASE 1 STUDY OF ISPINESIB (SB-715992) IN PEDIATRIC PATIENTS WITH RELAPSED OR REFRACTORY SOLID TUMORS Completed NCT00363272 Phase 1 ispinesib
16 A Phase I Clinical Trial of AZD2171 in Children With Recurrent or Progressive Central Nervous System (CNS) Tumors Completed NCT00326664 Phase 1 Cediranib Maleate
17 A Multi-Center Phase Ib Study of Oxaliplatin (NSC #266046) in Combination With Fluorouracil and Leucovorin in Pediatric Patients With Advanced Solid Tumors Completed NCT00281944 Phase 1 oxaliplatin;fluorouracil;leucovorin calcium
18 A Phase I Study of ABT-888, an Oral Inhibitor of Poly (ADP-Ribose) Polymerase and Temozolomide in Children With Recurrent/Refractory CNS Tumors Completed NCT00946335 Phase 1 veliparib;temozolomide
19 A PHASE I STUDY OF DEPSIPEPTIDE (NSC#630176, IND# 51810) IN PEDIATRIC PATIENTS WITH REFRACTORY SOLID TUMORS AND LEUKEMIAS Completed NCT00053963 Phase 1 romidepsin
20 A Pilot Study of Allogeneic Hematopoietic Cell Transplantation for Patients With High Grade Central Nervous System Malignancies Recruiting NCT04521946 Phase 1 Etoposide;Fludarabine Phosphate;Melphalan;Mycophenolate Mofetil;Tacrolimus;Thiotepa
21 Pilot Study of High-Dose Chemotherapy With Busulfan, Melphalan, and Topotecan Followed by Autologous Hematopoietic Stem Cell Transplant in Advanced Stage and Recurrent Tumors Active, not recruiting NCT00638898 Phase 1 busulfan;melphalan;topotecan hydrochloride
22 Microenvironment: Imaging/Implications in Brain Tumors; A Preliminary Investigation of the Biodistribution of [F-18]-EF5 in Patients With Brain Tumors Terminated NCT00110032 Phase 1 EF5
23 A Children's Oncology Group Protocol for Collecting and Banking Pediatric Brain Tumor Research Specimens Completed NCT00919750
24 Phase II Study of Proton Radiation Therapy for CNS Germ Cell Tumors: Evaluation of Acute and Late Side Effects Active, not recruiting NCT01049230

Search NIH Clinical Center for Central Nervous System Germ Cell Tumor

Genetic Tests for Central Nervous System Germ Cell Tumor

Anatomical Context for Central Nervous System Germ Cell Tumor

Organs/tissues related to Central Nervous System Germ Cell Tumor:

MalaCards : Pineal, Pituitary, Brain

Publications for Central Nervous System Germ Cell Tumor

Articles related to Central Nervous System Germ Cell Tumor:

(show all 12)
# Title Authors PMID Year
1
Roles of Tumor Markers in Central Nervous System Germ Cell Tumors Revisited with Histopathology-Proven Cases in a Large International Cohort. 62
35205726 2022
2
A Novel Germline SDHA Gene Mutation and Co-Occurring Somatic KIT Activating Mutation in a Patient With Pediatric Central Nervous System Germ Cell Tumor: Case Report. 62
35651799 2022
3
Central nervous system germ cell tumor, an archetypal AYA tumor and a model for pediatric and neuro-oncology collaboration, review from the EURACAN domain 10 group. 62
36248981 2022
4
Detecting non-germinomatous germ cell tumor component by arterial spin labeling perfusion-weighted MR imaging in central nervous system germ cell tumor. 62
33460957 2021
5
Treatment outcome and long-term follow-up of central nervous system germ cell tumor using upfront chemotherapy with subsequent photon or proton radiation therapy: a single tertiary center experience of 127 patients. 62
33036578 2020
6
Laser ablation-ICP-TOFMS imaging of germ cell tumors of patients undergoing platinum-based chemotherapy. 62
32525499 2020
7
Cognitive Profile of Children With Intracranial Germ Cell Tumor According to Tumor Location. 62
29746441 2018
8
Treatment Outcome in Patients with Primary Central Nervous System Germ Cell Tumour: Clinical Experience from a Regional Cancer Centre in North India. 62
28538229 2017
9
Highlights from the Third International Central Nervous System Germ Cell Tumour symposium: laying the foundations for future consensus. 62
23861728 2013
10
Reversible posterior leukoencephalopathy syndrome in Chinese children induced by chemotherapy: a review of five cases. 62
21282828 2011
11
Delayed surgical resection of central nervous system germ cell tumors. 62
11904022 2002
12
Chemotherapy without irradiation--a novel approach for newly diagnosed CNS germ cell tumors: results of an international cooperative trial. The First International Central Nervous System Germ Cell Tumor Study. 62
8918487 1996

Variations for Central Nervous System Germ Cell Tumor

Expression for Central Nervous System Germ Cell Tumor

Search GEO for disease gene expression data for Central Nervous System Germ Cell Tumor.

Pathways for Central Nervous System Germ Cell Tumor

GO Terms for Central Nervous System Germ Cell Tumor

Molecular functions related to Central Nervous System Germ Cell Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA-binding transcription factor activity GO:0003700 9.17 RELA OLIG2 MYCN FOXR2 FOXR1

Sources for Central Nervous System Germ Cell Tumor

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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