Central Nervous System Germinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CNT037 MIFTS: 34	Central Nervous System Germinoma Categories: Cancer diseases, Endocrine diseases, Neuronal diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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Aliases & Classifications for Central Nervous System Germinoma

MalaCards integrated aliases for Central Nervous System Germinoma:

Name: Central Nervous System Germinoma ¹¹ ¹⁹ ¹⁴ ⁷¹

Germinoma of the Central Nervous System ¹⁹ ⁵⁸

Intracranial Germinoma ¹⁹ ⁷¹

Germinoma of Cns ¹¹

Characteristics:

Age Of Onset:

Germinoma of the Central Nervous System: Adolescent,Adult,Childhood ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Neuronal diseases Endocrine diseases

See all MalaCards categories (disease lists)

Orphanet: ⁵⁸

Rare neurological diseases

Rare endocrine diseases

External Ids:

Disease Ontology ¹¹ DOID:4438

NCIt ⁴⁹ C7009

SNOMED-CT ⁶⁸ 1156833003

UMLS via Orphanet ⁷² C1333813

Orphanet ⁵⁸ ORPHA91352

UMLS ⁷¹ C1333813 C1334240

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Summaries for Central Nervous System Germinoma

Orphanet: ⁵⁸ A rare primary germ cell tumor of central nervous system characterized by a space-occupying lesion usually arising in structures around the third ventricle, most commonly the region of the pineal gland and the suprasellar compartment. It is composed of uniform cells resembling primitive germ cells. Clinical manifestations depend on the tumor site and include hydrocephalus, visual disturbances, and endocrine abnormalities. Prognosis is favorable in pure germinomas due to high radiosensitivity.

MalaCards based summary: Central Nervous System Germinoma, also known as germinoma of the central nervous system, is related to germinoma and brain germinoma. An important gene associated with Central Nervous System Germinoma is JMJD1C (Jumonji Domain Containing 1C), and among its related pathways/superpathways is Cell differentiation - expanded index. The drugs Bleomycin and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include pineal, spinal cord and brain.

GARD: ¹⁹ A germinoma that arises from the pineal gland.

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Related Diseases for Central Nervous System Germinoma

Diseases in the Central Nervous System Germinoma family:

Adult Central Nervous System Germinoma

Diseases related to Central Nervous System Germinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 119)

#	Related Disease	Score	Top Affiliating Genes
1	germinoma	30.2	SALL4 MIR371A MIR302A ESRG
2	brain germinoma	30.1	MIR371A ESRG
3	dysgerminoma of ovary	29.4	SALL4 MIR371A
4	malignant teratoma	29.2	SALL4 MIR371A MIR302C
5	endodermal sinus tumor	28.9	SALL4 MIR371A MIR302C MIR302A
6	childhood central nervous system germinoma	11.6
7	adult central nervous system germinoma	11.4
8	central diabetes insipidus	10.5
9	diabetes insipidus	10.5
10	germ cell tumor	10.5
11	pituitary hormone deficiency, combined, 2	10.4
12	teratoma	10.3
13	obstructive hydrocephalus	10.3
14	diabetes insipidus, neurohypophyseal	10.3
15	down syndrome	10.3
16	tatton-brown-rahman syndrome	10.2
17	brain cancer	10.2
18	spastic paraplegia, ataxia, and mental retardation	10.1
19	dysgerminoma	10.1
20	growth hormone deficiency	10.1
21	glioma susceptibility 1	10.1
22	medulloblastoma	10.1
23	testicular germ cell tumor	10.1
24	toe syndactyly, telecanthus, and anogenital and renal malformations	10.1
25	meningioma, familial	10.1
26	lymphoma	10.1
27	hydrocephalus	10.1
28	papilledema	10.1
29	pineoblastoma	10.1
30	glioblastoma	10.1
31	neurilemmoma	10.1
32	embryonal carcinoma	10.1
33	central nervous system cancer	10.1
34	pituitary adenoma	10.1
35	seminoma	10.1
36	hemangioblastoma	10.1
37	pituitary gland disease	10.1
38	hypopituitarism	10.1
39	49, xxxxy syndrome	10.1
40	precocious puberty	10.1
41	epidermoid cysts	10.1
42	leptin deficiency or dysfunction	10.1
43	hypogonadotropic hypogonadism	10.1
44	spinal cord disease	10.1
45	mixed germ cell cancer	10.1
46	choriocarcinoma	10.1
47	movement disease	10.1
48	embryonal testis carcinoma	10.1
49	testis seminoma	10.1
50	47 xxx syndrome	10.1

Graphical network of the top 20 diseases related to Central Nervous System Germinoma:

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Symptoms & Phenotypes for Central Nervous System Germinoma

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Drugs & Therapeutics for Central Nervous System Germinoma

Drugs for Central Nervous System Germinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Bleomycin

Approved, Investigational

Phase 2

9041-93-4, 11056-06-7

5360373

Carboplatin

Approved

Phase 2

41575-94-4

10339178 38904

Etoposide

Approved

Phase 2

33419-42-0

36462

Cyclophosphamide

Approved, Investigational

Phase 2

50-18-0, 6055-19-2

2907

Picropodophyllin

Approved, Investigational

Phase 2

518-28-5, 477-47-4

10607 72435

Ifosfamide

Approved

Phase 2

3778-73-2

3690

Mechlorethamine

Approved, Investigational

Phase 2

51-75-2

4033

Palifosfamide

Investigational

Phase 2

31645-39-3

100427

Immunosuppressive Agents

Phase 2

Immunologic Factors

Phase 2

Anti-Bacterial Agents

Phase 2

Antirheumatic Agents

Phase 2

Antibiotics, Antitubercular

Phase 2

Alkylating Agents

Phase 2

Antineoplastic Agents, Alkylating

Phase 2

Etoposide phosphate

Phase 2

16760419

Antimitotic Agents

Phase 2

Keratolytic Agents

Phase 2

Tubulin Modulators

Phase 2

Dermatologic Agents

Phase 2

Sunitinib

Approved, Investigational

Phase 1

557795-19-4

5329102

Vorinostat

Approved, Investigational

Phase 1

149647-78-9

5311

Bortezomib

Approved, Investigational

Phase 1

179324-69-7

387447 93860

Temozolomide

Approved, Investigational

Phase 1

85622-93-1

5394

Levoleucovorin

Approved, Experimental, Investigational

Phase 1

68538-85-2, 58-05-9, 73951-54-9

149436 6006

Fluorouracil

Approved

Phase 1

51-21-8

3385

Oxaliplatin

Approved, Investigational

Phase 1

61825-94-3

43805 11947679 6857599

Dexamethasone acetate

Approved, Investigational, Vet_approved

Phase 1

1177-87-3

3680

Dexamethasone

Approved, Investigational, Vet_approved

Phase 1

50-02-2

3003 5743

D-Tyrosine

Approved, Experimental, Investigational, Nutraceutical

Phase 1

133585-56-5, 60-18-4, 556-02-5

1153 6057

Folic acid

Approved, Nutraceutical, Vet_approved

Phase 1

59-30-3

6037

Angiogenesis Inhibitors

Phase 1

Protein Kinase Inhibitors

Phase 1

Histone Deacetylase Inhibitors

Phase 1

Vitamins

Phase 1

Folate

Phase 1

Vitamin B9

Phase 1

Trace Elements

Phase 1

Vitamin B Complex

Phase 1

Antimetabolites

Phase 1

Antidotes

Phase 1

Calcium, Dietary

Phase 1

Micronutrients

Phase 1

Protective Agents

Phase 1

Antineoplastic Agents, Hormonal

Phase 1

R04929097

Phase 1

Hormones

Phase 1

Hormone Antagonists

Phase 1

Antiemetics

Phase 1

glucocorticoids

Phase 1

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Treatment of Intracranial Germinoma With Chemotherapy Prior to Reduced Dose and Volume of Radiotherapy	Unknown status	NCT02782754	Phase 2	Carboplatin;Etoposide;Cyclophosphamide;Bleomycin
2	Phase 2 Trial of Response-Based Radiation Therapy for Patients With Localized Central Nervous System Germ Cell Tumors (CNS GCT)	Active, not recruiting	NCT01602666	Phase 2	Carboplatin;Etoposide;Ifosfamide
3	A Phase I Study of Sunitinib (SU11248), an Oral Multi-Targeted Tyrosine Kinase Inhibitor, in Children With Refractory Solid Tumors	Completed	NCT00387920	Phase 1	sunitinib malate
4	A Phase I Study of Vorinostat and Bortezomib in Children With Refractory or Recurrent Solid Tumors, Including CNS Tumors and Lymphomas	Completed	NCT00994500	Phase 1	vorinostat;bortezomib
5	A Phase I Study of Pazopanib as a Single Agent for Children With Relapsed or Refractory Solid Tumors	Completed	NCT00929903	Phase 1	pazopanib hydrochloride
6	A Phase I Study of SAHA and Temozolomide in Children With Relapsed or Refractory Primary Brain or Spinal Cord Tumors	Completed	NCT01076530	Phase 1	vorinostat;temozolomide
7	A Multi-Center Phase Ib Study of Oxaliplatin (NSC #266046) in Combination With Fluorouracil and Leucovorin in Pediatric Patients With Advanced Solid Tumors	Completed	NCT00281944	Phase 1	oxaliplatin;fluorouracil;leucovorin calcium
8	A PHASE 1/2 STUDY OF RO4929097, AN ORAL SMALL MOLECULE INHIBITOR OF GAMMA-SECRETASE, IN CHILDREN WITH RELAPSED/REFRACTORY SOLID OR CNS TUMORS, LYMPHOMA, OR T-CELL LEUKEMIA	Terminated	NCT01088763	Phase 1	gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone

Search NIH Clinical Center for Central Nervous System Germinoma

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Genetic Tests for Central Nervous System Germinoma

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Anatomical Context for Central Nervous System Germinoma

Organs/tissues related to Central Nervous System Germinoma:

MalaCards : Pineal, Spinal Cord, Brain, Medulla Oblongata, Bone Marrow, Thalamus, Pituitary

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Publications for Central Nervous System Germinoma

Articles related to Central Nervous System Germinoma:

(show top 50) (show all 332)

#	Title	Authors	PMID	Year
1	Diencephalic syndrome in a female child due to intracranial germinoma: a case report. ⁶²	Ju Y...He J	35507081	2022
2	Factors Influencing Craniospinal Relapse of Intracranial Germinoma After Complete Remission. ⁶²	Tsurubuchi T...Ishikawa E	35842173	2022
3	Intracranial germinoma in the lateral ventricle with polydipsia and polyuria: a case report and literature review. ⁶²	Kuranari Y...Hasegawa T	36271932	2022
4	Outcomes of intracranial germinoma-A retrospective multinational Asian study on effect of clinical presentation and differential treatment strategies. ⁶²	Koh KN...Kim JY	34935949	2022
5	Radiographic Findings of an Intracranial Germinoma in a 42-Year-Old Male. ⁶²	Ostreni I...Morvillo G	36060381	2022
6	Optic Nerve Germinoma and Transient Spontaneous Regression-More Than Meets the Eye. ⁶²	Geurten C...English M	34654758	2022
7	Chemotherapy plus focal radiation therapy for localized intracranial germinoma: How little is enough? ⁶²	Farouk Sait S...Karajannis MA	35171291	2022
8	Primary central nervous system germinoma as a rare cause of diffuse ependymal involvement in adults. ⁶²	Sanesteban Beceiro E...Ginestal Lopez RC	35477521	2022
9	Diagnostic radiation-induced regression of a metastatic primary intracranial germinoma: a case report. ⁶²	Woo PYM...Chan KY	30392398	2022
10	Studies on anti-rabphilin-3A antibodies in 15 consecutive patients presenting with central diabetes insipidus at a single referral center. ⁶²	Arihara Z...Sugimura Y	35292721	2022
11	The features of acute lymphocytic leukemia with intracranial germinoma in a patient with Li-Fraumeni syndrome: a case description. ⁶²	Liang Y...Cao W	35284289	2022
12	Vinblastine monotherapy induction prior to radiotherapy for patients with intracranial germinoma during the COVID-19 pandemic. ⁶²	Murray MJ...Nicholson JC	34520101	2022
13	Value of C-11 methionine PET/CT in patients with intracranial germinoma. ⁶²	Park YJ...Moon SH	35130327	2022
14	Classification of Gliomas and Germinomas of the Basal Ganglia by Transfer Learning. ⁶²	Ye N...Li X	35311111	2022
15	Bifocal lesions have a poorer treatment outcome than a single lesion in adult patients with intracranial germinoma. ⁶²	Kang YM...Chen YW	35231071	2022
16	A Novel Germline SDHA Gene Mutation and Co-Occurring Somatic KIT Activating Mutation in a Patient With Pediatric Central Nervous System Germ Cell Tumor: Case Report. ⁶²	Yue X...Wang G	35651799	2022
17	Bilateral Optic Neuropathy Mimicking Neuromyelitis Optica in the Setting of Intracranial Germinoma. ⁶²	Abdalla KMS...Prabhu AM	34992988	2021
18	Primary intracranial germinoma mimicking meningioma in an elderly patient. ⁶²	Jacques A...Ducray F	33795143	2021
19	Long-Term Outcomes and Sequelae Analysis of Intracranial Germinoma: Need to Reduce the Extended-Field Radiotherapy Volume and Dose to Minimize Late Sequelae. ⁶²	Lee JH...Kim IH	33494128	2021
20	The clinical and imaging features of infratentorial germinomas compared with supratentorial ectopic germinomas. ⁶²	Li W...Ma J	32854527	2021
21	Characteristics of growth disturbances in patients with intracranial germinomas of different origins. ⁶²	Li B...Qiu X	34028562	2021
22	Letter to the Editor Regarding "Spontaneous Regression in Intracranial Germinoma: Case Report and Literature Review". ⁶²	Yoneoka Y	34243646	2021
23	Molecular Pathology and Targeted Therapies for Personalized Management of Central Nervous System Germinoma. ⁶²	Ilcus C...Silaghi CA	34357128	2021
24	Primary central nervous system germinoma as a rare cause of diffuse ependymal involvement in adults. ⁶²	Sanesteban Beceiro E...Ginestal Lopez RC	34256999	2021
25	Primary intracranial germ cell tumour originating from right brachium Pontis with hypertrophic Olivary degeneration: a case report. ⁶²	Li Y...Qiu X	34034682	2021
26	[Germinoma in a patient with emaciation and growth retardation. Case report]. ⁶²	Ciucio AY...Schenone N	33749211	2021
27	Neoadjuvant Chemotherapy and Whole Ventricular Irradiation for Pure Intracranial Germinoma: A Comparison of Three Brain-Sparing Techniques. ⁶²	Nosrati J...Wong K	33824821	2021
28	Diabetes insipidus with impaired vision caused by germinoma and perioptic meningeal seeding: A case report. ⁶²	Yang N...Zhang HB	33748249	2021
29	Radiotherapy-induced glioblastoma: distinct differences in overall survival, tumor location, pMGMT methylation and primary tumor epidemiology in Hong Kong chinese patients. ⁶²	Woo PYM...Poon WS	33576706	2021
30	Intracranial Germinoma Misdiagnosed as Hyperthyroidism: A Case Report and Review of the Literature. ⁶²	Tian J...Huang H	35140682	2021
31	The radiotherapy utilization rate in pediatric tumors: An analysis of 13,305 patients. ⁶²	Bishr MK...Mousa AG	33039421	2021
32	A Case of Synchronous Occurrence of Intracranial Germinoma and Systemic Sarcoidosis. ⁶²	Hyakutake Y...Kumabe T	35079529	2021
33	Necessity for craniospinal irradiation of germinoma with positive cytology without spinal lesion on MR imaging-A controversy. ⁶²	Kanamori M...Nishikawa R	34355172	2021
34	[Treatment outcomes in patients with central nervous system germinoma (neuro-ophthalmic aspects)]. ⁶²	Serova NK...Trunin YY	33560623	2021
35	Induction Chemotherapy Reduces Radiation Therapy Dose and Volume in the Treatment of Intracranial Germinoma: Results of the SMC-G13 Trial. ⁶²	Lee JW...Shin HJ	32502506	2020
36	Optimization of Intracranial Germinoma Treatment: Radiotherapy Alone with Reduced Volume and Dose. ⁶²	Byun HK...Suh CO	32434039	2020
37	A Case Report Emphasizing the Importance of Early Diagnosis and Management of Intracranial Germinoma. ⁶²	Ram N...Mushtaq N	33391952	2020
38	An Unusual Case of Primary Intracranial Germinoma with Diffuse Subarachnoid Spread Masquerading as Tuberculous Meningitis. ⁶²	Sharma AK...Saran RK	33708683	2020
39	Optic atrophy secondary to intracranial germinoma. ⁶²	Lee WA...Liao IC	32167548	2020
40	Giant intracranial germinoma. ⁶²	Hidalgo J...Cohen AR	32737736	2020
41	Pituitary germinomas: a multi-institutional study analyzing patient demographics and management patterns. ⁶²	Bhimani AD...Mehta AI	32388804	2020
42	Pediatric Central Nervous System Germinoma: What Can We Understand From a Worldwide Effort to Maximize Cure and Minimize Risk? ⁶²	Hill-Kayser CE...Breneman J	32275995	2020
43	A Rare Case of a Pediatric Medullary Intracranial Germinoma. ⁶²	Seifert K...Malhotra A	32147555	2020
44	Intracranial Germinoma Masquerading as Secondary Granulomatous Hypophysitis: A Case Report and Review of Literature. ⁶²	Pal R...Dutta P	31269501	2020
45	Clinical and neuropsychological outcome of pediatric non-midline central nervous system germinoma treated with chemotherapy and reduced dose/volume irradiation: The Children's Hospital Los Angeles experience. ⁶²	Yeo KK...Dhall G	31502379	2019
46	Laparoscopic Sleeve Gastrectomy on Severe Obesity after Intracranial Germinoma Treatment: A Case Report. ⁶²	Nezu M...Satoh F	31776301	2019
47	Spontaneous Regression in Intracranial Germinoma: Case Report and Literature Review. ⁶²	Zhang S...Ju Y	31295590	2019
48	Upfront chemotherapy followed by response adaptive radiotherapy for intracranial germinoma: Prospective multicenter cohort study. ⁶²	Lee DS...Kim DS	31319280	2019
49	Primary cavernous sinus germinoma with atypical extension pattern: a case report and review of the literature. ⁶²	Sakakura K...Matsumura A	30796559	2019
50	De Novo Pineal Region Germinoma in the Seventh Decade of Life: A Case Report. ⁶²	Sano M...Fujii Y	31417835	2019

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Genes for Central Nervous System Germinoma

Genes related to Central Nervous System Germinoma (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	JMJD1C	Jumonji Domain Containing 1C	Protein Coding	25	Susceptibility factor ⁵⁸	24896186
2	ESRG	Embryonic Stem Cell Related	RNA Gene	5.16	DISEASES inferred ¹⁴
3	MIR302A	MicroRNA 302a	RNA Gene	4.88	DISEASES inferred ¹⁴
4	RTRAF	RNA Transcription, Translation And Transport Factor	Protein Coding	4.71	DISEASES inferred ¹⁴
5	MIR302C	MicroRNA 302c	RNA Gene	4.69	DISEASES inferred ¹⁴
6	MIR371A	MicroRNA 371a	RNA Gene	4.63	DISEASES inferred ¹⁴
7	SALL4	Spalt Like Transcription Factor 4	Protein Coding	4.39	DISEASES inferred ¹⁴