MCID: CNT037
MIFTS: 31

Central Nervous System Germinoma

Categories: Cancer diseases, Endocrine diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Central Nervous System Germinoma

MalaCards integrated aliases for Central Nervous System Germinoma:

Name: Central Nervous System Germinoma 12 20 15 70
Germinoma of the Central Nervous System 20 58
Intracranial Germinoma 20 70
Germinoma of Cns 12

Characteristics:

Orphanet epidemiological data:

58
germinoma of the central nervous system
Inheritance: Not applicable; Age of onset: Adolescent,Adult,Childhood;

Classifications:

Orphanet: 58  
Rare neurological diseases
Rare endocrine diseases


External Ids:

Disease Ontology 12 DOID:4438
NCIt 50 C7009
UMLS via Orphanet 71 C1333813
Orphanet 58 ORPHA91352
UMLS 70 C1333813 C1334240

Summaries for Central Nervous System Germinoma

MalaCards based summary : Central Nervous System Germinoma, also known as germinoma of the central nervous system, is related to germinoma and dysgerminoma. An important gene associated with Central Nervous System Germinoma is JMJD1C (Jumonji Domain Containing 1C), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Preimplantation Embryo. The drugs Etoposide and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include pituitary, pineal and testis.

Related Diseases for Central Nervous System Germinoma

Diseases in the Central Nervous System Germinoma family:

Adult Central Nervous System Germinoma

Diseases related to Central Nervous System Germinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 germinoma 30.9 POU5F1 MIR302A ALPP
2 dysgerminoma 30.1 MIR302C ALPP
3 seminoma 30.0 POU5F1 ALPP
4 dysgerminoma of ovary 30.0 POU5F1 ALPP
5 embryonal carcinoma 29.7 POU5F1 MIR302A
6 endodermal sinus tumor 29.6 MIR302C MIR302A ALPP
7 childhood central nervous system germinoma 11.5
8 adult central nervous system germinoma 11.4
9 diabetes insipidus 10.5
10 germ cells tumors 10.4
11 pituitary hormone deficiency, combined, 2 10.3
12 teratoma 10.3
13 brain germinoma 10.3
14 obstructive hydrocephalus 10.2
15 ataxia and polyneuropathy, adult-onset 10.1
16 growth hormone deficiency 10.1
17 medulloblastoma 10.1
18 meningioma, familial 10.1
19 lymphoma 10.1
20 intracranial meningioma 10.1
21 hydrocephalus 10.1
22 papilledema 10.1
23 pineoblastoma 10.1
24 glioblastoma 10.1
25 nervous system cancer 10.1
26 neurilemmoma 10.1
27 central nervous system cancer 10.1
28 pituitary adenoma 10.1
29 secretory meningioma 10.1
30 lymphoplasmacyte-rich meningioma 10.1
31 hemangioblastoma 10.1
32 pituitary gland disease 10.1
33 pineal region germinoma 10.1
34 hypopituitarism 10.1
35 precocious puberty 10.1
36 epidermoid cysts 10.0
37 down syndrome 10.0
38 cauda equina syndrome 10.0
39 choriocarcinoma 10.0
40 testicular yolk sac tumor 10.0
41 testis seminoma 10.0
42 47,xyy 10.0
43 lymphocytic hypophysitis 10.0
44 headache 10.0
45 mixed germ cell tumor 10.0
46 gonadoblastoma 10.0 POU5F1 ALPP
47 spermatocytoma 10.0 POU5F1 CT45A1
48 malignant teratoma 10.0 POU5F1 MIR302C
49 testicular disease 9.9 POU5F1 MIR302A
50 choledocholithiasis 9.9 MIR302C ALPP

Graphical network of the top 20 diseases related to Central Nervous System Germinoma:



Diseases related to Central Nervous System Germinoma

Symptoms & Phenotypes for Central Nervous System Germinoma

Drugs & Therapeutics for Central Nervous System Germinoma

Drugs for Central Nervous System Germinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 2 33419-42-0 36462
2
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
3
Bleomycin Approved, Investigational Phase 2 11056-06-7 5360373
4
Carboplatin Approved Phase 2 41575-94-4 10339178 498142 38904
5 Antirheumatic Agents Phase 2
6 Immunosuppressive Agents Phase 2
7 Etoposide phosphate Phase 2
8 Antibiotics, Antitubercular Phase 2
9 Alkylating Agents Phase 2
10 Anti-Bacterial Agents Phase 2
11 Immunologic Factors Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Intracranial Germinoma With Chemotherapy Prior to Reduced Dose and Volume of Radiotherapy Unknown status NCT02782754 Phase 2 Carboplatin;Etoposide;Cyclophosphamide;Bleomycin

Search NIH Clinical Center for Central Nervous System Germinoma

Genetic Tests for Central Nervous System Germinoma

Anatomical Context for Central Nervous System Germinoma

MalaCards organs/tissues related to Central Nervous System Germinoma:

40
Pituitary, Pineal, Testis, Spinal Cord, Medulla Oblongata, Bone Marrow, Brain

Publications for Central Nervous System Germinoma

Articles related to Central Nervous System Germinoma:

(show top 50) (show all 302)
# Title Authors PMID Year
1
[Germinoma in a patient with emaciation and growth retardation. Case report]. 61
33749211 2021
2
Primary intracranial germinoma mimicking meningioma in an elderly patient. 61
33795143 2021
3
Diabetes insipidus with impaired vision caused by germinoma and perioptic meningeal seeding: A case report. 61
33748249 2021
4
Radiotherapy-induced glioblastoma: distinct differences in overall survival, tumor location, pMGMT methylation and primary tumor epidemiology in Hong Kong chinese patients. 61
33576706 2021
5
[Treatment outcomes in patients with central nervous system germinoma (neuro-ophthalmic aspects)]. 61
33560623 2021
6
The radiotherapy utilization rate in pediatric tumors: An analysis of 13,305 patients. 61
33039421 2021
7
Long-Term Outcomes and Sequelae Analysis of Intracranial Germinoma: Need to Reduce the Extended-Field Radiotherapy Volume and Dose to Minimize Late Sequelae. 61
33494128 2021
8
Optimization of Intracranial Germinoma Treatment: Radiotherapy Alone with Reduced Volume and Dose. 61
32434039 2020
9
Induction Chemotherapy Reduces Radiation Therapy Dose and Volume in the Treatment of Intracranial Germinoma: Results of the SMC-G13 Trial. 61
32502506 2020
10
A Case Report Emphasizing the Importance of Early Diagnosis and Management of Intracranial Germinoma. 61
33391952 2020
11
An Unusual Case of Primary Intracranial Germinoma with Diffuse Subarachnoid Spread Masquerading as Tuberculous Meningitis. 61
33708683 2020
12
Optic atrophy secondary to intracranial germinoma. 61
32167548 2020
13
Giant intracranial germinoma. 61
32737736 2020
14
The clinical and imaging features of infratentorial germinomas compared with supratentorial ectopic germinomas. 61
32854527 2020
15
Pituitary germinomas: a multi-institutional study analyzing patient demographics and management patterns. 61
32388804 2020
16
A Rare Case of a Pediatric Medullary Intracranial Germinoma. 61
32147555 2020
17
Pediatric Central Nervous System Germinoma: What Can We Understand From a Worldwide Effort to Maximize Cure and Minimize Risk? 61
32275995 2020
18
Intracranial Germinoma Masquerading as Secondary Granulomatous Hypophysitis: A Case Report and Review of Literature. 61
31269501 2020
19
Clinical and neuropsychological outcome of pediatric non-midline central nervous system germinoma treated with chemotherapy and reduced dose/volume irradiation: The Children's Hospital Los Angeles experience. 61
31502379 2019
20
Laparoscopic Sleeve Gastrectomy on Severe Obesity after Intracranial Germinoma Treatment: A Case Report. 61
31776301 2019
21
Spontaneous Regression in Intracranial Germinoma: Case Report and Literature Review. 61
31295590 2019
22
Upfront chemotherapy followed by response adaptive radiotherapy for intracranial germinoma: Prospective multicenter cohort study. 61
31319280 2019
23
Primary cavernous sinus germinoma with atypical extension pattern: a case report and review of the literature. 61
30796559 2019
24
De Novo Pineal Region Germinoma in the Seventh Decade of Life: A Case Report. 61
31417835 2019
25
A Central Role of Radiation Therapy in Central Nervous System Germinoma. 61
31327428 2019
26
Rapid, label-free detection of intracranial germinoma using multiphoton microscopy. 61
31572743 2019
27
Redefining Ventricular Target Volume in Germinoma: Is Inclusion of Temporal Horns Necessary? 61
30940528 2019
28
Treatment outcomes of intracranial germinoma: a retrospective analysis of 170 patients from a single institution. 61
30209611 2019
29
Re-irradiation for Paediatric Tumours. 61
30385005 2019
30
Bifocal germinoma in a patient with 16p11.2 microdeletion syndrome. 61
30738016 2019
31
A synchronous occurrence of bifocal intracranial germinoma and bilateral testicular epidermoid cyst in an adolescent patient with Klinefelter`s syndrome. 61
31916730 2019
32
Treatment outcomes based on radiation therapy fields for bifocal germinoma: Synchronous or disseminated disease? 61
31581215 2019
33
Secondary glioblastoma after treatment of intracranial germinoma - would radiation-only therapy still be safe? Case report. 61
30445947 2018
34
Diagnostic radiation-induced regression of a metastatic primary intracranial germinoma: a case report. 61
30392398 2018
35
Placental alkaline phosphatase levels in cerebrospinal fluid can have a decisive role in the differential diagnosis of intracranial germ cell tumors. 61
30265190 2018
36
Intracranial germinoma causing cerebral haemiatrophy and hypopituitarism. 61
29378909 2018
37
High-dose chemotherapy with autologous stem cell transplantation spares re-irradiation for recurrent intracranial germinoma. 61
29693779 2018
38
Widespread Intra-abdominal Carcinomatosis from a Rhabdoid Meningioma after Placement of a Ventriculoperitoneal Shunt: A Case Report and Review of the Literature. 61
29682040 2018
39
Practice patterns and survival outcomes of intracranial germinoma: an analysis of the National Cancer Database. 61
29177595 2018
40
PD-1/PD-L1 expression in a series of intracranial germinoma and its association with Foxp3+ and CD8+ infiltrating lymphocytes. 61
29617441 2018
41
Widespread Intra-abdominal Carcinomatosis from a Rhabdoid Meningioma after Placement of a Ventriculoperitoneal Shunt: A Case Report and Review of the Literature. 61
29492156 2018
42
Clinical case seminar: Familial intracranial germinoma. 61
30379323 2018
43
A rare case report and literatures review on primary germinoma in cerebellar hemisphere. 61
28689343 2017
44
Visual complaints in intracranial germinomas. 61
28436607 2017
45
Radiotherapy and chemotherapy plus radiation in the treatment of patients with pure intracranial germinoma: A meta-analysis. 61
28602629 2017
46
Intracranial Germinoma: Systemic Chemotherapy in Addition to Dose-Reduced Radiation Therapy. 61
28614087 2017
47
Pediatric intracranial germinoma: use chemotherapy first. 61
29044451 2017
48
Adipsic diabetes insipidus revealing a bifocal intracranial germinoma. 61
28483362 2017
49
Anomalous intracranial germinoma with unilateral cerebral peduncle swelling. 61
28283777 2017
50
Craniospinal irradiation using helical tomotherapy for central nervous system tumors. 61
28096196 2017

Variations for Central Nervous System Germinoma

Expression for Central Nervous System Germinoma

Search GEO for disease gene expression data for Central Nervous System Germinoma.

Pathways for Central Nervous System Germinoma

Pathways related to Central Nervous System Germinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.28 POU5F1 ALPP
2 10.73 POU5F1 MIR302A
3 10.2 MIR302C MIR302A

GO Terms for Central Nervous System Germinoma

Sources for Central Nervous System Germinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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