MCID: CNT037
MIFTS: 34

Central Nervous System Germinoma

Categories: Cancer diseases, Endocrine diseases, Neuronal diseases, Rare diseases
Data Licensing
For inquiries, contact:

Aliases & Classifications for Central Nervous System Germinoma

MalaCards integrated aliases for Central Nervous System Germinoma:

Name: Central Nervous System Germinoma 11 19 14 71
Germinoma of the Central Nervous System 19 58
Intracranial Germinoma 19 71
Germinoma of Cns 11

Characteristics:


Age Of Onset:

Germinoma of the Central Nervous System: Adolescent,Adult,Childhood 58

Classifications:

Orphanet: 58  
Rare neurological diseases
Rare endocrine diseases


External Ids:

Disease Ontology 11 DOID:4438
NCIt 49 C7009
SNOMED-CT 68 1156833003
UMLS via Orphanet 72 C1333813
Orphanet 58 ORPHA91352
UMLS 71 C1333813 C1334240

Summaries for Central Nervous System Germinoma

Orphanet: 58 A rare primary germ cell tumor of central nervous system characterized by a space-occupying lesion usually arising in structures around the third ventricle, most commonly the region of the pineal gland and the suprasellar compartment. It is composed of uniform cells resembling primitive germ cells. Clinical manifestations depend on the tumor site and include hydrocephalus, visual disturbances, and endocrine abnormalities. Prognosis is favorable in pure germinomas due to high radiosensitivity.

MalaCards based summary: Central Nervous System Germinoma, also known as germinoma of the central nervous system, is related to germinoma and brain germinoma. An important gene associated with Central Nervous System Germinoma is JMJD1C (Jumonji Domain Containing 1C), and among its related pathways/superpathways is Cell differentiation - expanded index. The drugs Bleomycin and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include pineal, spinal cord and brain.

GARD: 19 A germinoma that arises from the pineal gland.

Related Diseases for Central Nervous System Germinoma

Diseases in the Central Nervous System Germinoma family:

Adult Central Nervous System Germinoma

Diseases related to Central Nervous System Germinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 119)
# Related Disease Score Top Affiliating Genes
1 germinoma 30.2 SALL4 MIR371A MIR302A ESRG
2 brain germinoma 30.1 MIR371A ESRG
3 dysgerminoma of ovary 29.4 SALL4 MIR371A
4 malignant teratoma 29.2 SALL4 MIR371A MIR302C
5 endodermal sinus tumor 28.9 SALL4 MIR371A MIR302C MIR302A
6 childhood central nervous system germinoma 11.6
7 adult central nervous system germinoma 11.4
8 central diabetes insipidus 10.5
9 diabetes insipidus 10.5
10 germ cell tumor 10.5
11 pituitary hormone deficiency, combined, 2 10.4
12 teratoma 10.3
13 obstructive hydrocephalus 10.3
14 diabetes insipidus, neurohypophyseal 10.3
15 down syndrome 10.3
16 tatton-brown-rahman syndrome 10.2
17 brain cancer 10.2
18 spastic paraplegia, ataxia, and mental retardation 10.1
19 dysgerminoma 10.1
20 growth hormone deficiency 10.1
21 glioma susceptibility 1 10.1
22 medulloblastoma 10.1
23 testicular germ cell tumor 10.1
24 toe syndactyly, telecanthus, and anogenital and renal malformations 10.1
25 meningioma, familial 10.1
26 lymphoma 10.1
27 hydrocephalus 10.1
28 papilledema 10.1
29 pineoblastoma 10.1
30 glioblastoma 10.1
31 neurilemmoma 10.1
32 embryonal carcinoma 10.1
33 central nervous system cancer 10.1
34 pituitary adenoma 10.1
35 seminoma 10.1
36 hemangioblastoma 10.1
37 pituitary gland disease 10.1
38 hypopituitarism 10.1
39 49, xxxxy syndrome 10.1
40 precocious puberty 10.1
41 epidermoid cysts 10.1
42 leptin deficiency or dysfunction 10.1
43 hypogonadotropic hypogonadism 10.1
44 spinal cord disease 10.1
45 mixed germ cell cancer 10.1
46 choriocarcinoma 10.1
47 movement disease 10.1
48 embryonal testis carcinoma 10.1
49 testis seminoma 10.1
50 47 xxx syndrome 10.1

Graphical network of the top 20 diseases related to Central Nervous System Germinoma:



Diseases related to Central Nervous System Germinoma

Symptoms & Phenotypes for Central Nervous System Germinoma

Drugs & Therapeutics for Central Nervous System Germinoma

Drugs for Central Nervous System Germinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 54)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Bleomycin Approved, Investigational Phase 2 9041-93-4, 11056-06-7 5360373
2
Carboplatin Approved Phase 2 41575-94-4 10339178 38904
3
Etoposide Approved Phase 2 33419-42-0 36462
4
Cyclophosphamide Approved, Investigational Phase 2 50-18-0, 6055-19-2 2907
5
Picropodophyllin Approved, Investigational Phase 2 518-28-5, 477-47-4 10607 72435
6
Ifosfamide Approved Phase 2 3778-73-2 3690
7
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
8
Palifosfamide Investigational Phase 2 31645-39-3 100427
9 Immunosuppressive Agents Phase 2
10 Immunologic Factors Phase 2
11 Anti-Bacterial Agents Phase 2
12 Antirheumatic Agents Phase 2
13 Antibiotics, Antitubercular Phase 2
14 Alkylating Agents Phase 2
15 Antineoplastic Agents, Alkylating Phase 2
16
Etoposide phosphate Phase 2 16760419
17 Antimitotic Agents Phase 2
18 Keratolytic Agents Phase 2
19 Tubulin Modulators Phase 2
20 Dermatologic Agents Phase 2
21
Sunitinib Approved, Investigational Phase 1 557795-19-4 5329102
22
Vorinostat Approved, Investigational Phase 1 149647-78-9 5311
23
Bortezomib Approved, Investigational Phase 1 179324-69-7 387447 93860
24
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
25
Levoleucovorin Approved, Experimental, Investigational Phase 1 68538-85-2, 58-05-9, 73951-54-9 149436 6006
26
Fluorouracil Approved Phase 1 51-21-8 3385
27
Oxaliplatin Approved, Investigational Phase 1 61825-94-3 43805 11947679 6857599
28
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 1 1177-87-3 3680
29
Dexamethasone Approved, Investigational, Vet_approved Phase 1 50-02-2 3003 5743
30
D-Tyrosine Approved, Experimental, Investigational, Nutraceutical Phase 1 133585-56-5, 60-18-4, 556-02-5 1153 6057
31
Folic acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
32 Angiogenesis Inhibitors Phase 1
33 Protein Kinase Inhibitors Phase 1
34 Histone Deacetylase Inhibitors Phase 1
35 Vitamins Phase 1
36 Folate Phase 1
37 Vitamin B9 Phase 1
38 Trace Elements Phase 1
39 Vitamin B Complex Phase 1
40 Antimetabolites Phase 1
41 Antidotes Phase 1
42 Calcium, Dietary Phase 1
43 Micronutrients Phase 1
44 Protective Agents Phase 1
45 Antineoplastic Agents, Hormonal Phase 1
46 R04929097 Phase 1
47 Hormones Phase 1
48 Hormone Antagonists Phase 1
49 Antiemetics Phase 1
50 glucocorticoids Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment of Intracranial Germinoma With Chemotherapy Prior to Reduced Dose and Volume of Radiotherapy Unknown status NCT02782754 Phase 2 Carboplatin;Etoposide;Cyclophosphamide;Bleomycin
2 Phase 2 Trial of Response-Based Radiation Therapy for Patients With Localized Central Nervous System Germ Cell Tumors (CNS GCT) Active, not recruiting NCT01602666 Phase 2 Carboplatin;Etoposide;Ifosfamide
3 A Phase I Study of Sunitinib (SU11248), an Oral Multi-Targeted Tyrosine Kinase Inhibitor, in Children With Refractory Solid Tumors Completed NCT00387920 Phase 1 sunitinib malate
4 A Phase I Study of Vorinostat and Bortezomib in Children With Refractory or Recurrent Solid Tumors, Including CNS Tumors and Lymphomas Completed NCT00994500 Phase 1 vorinostat;bortezomib
5 A Phase I Study of Pazopanib as a Single Agent for Children With Relapsed or Refractory Solid Tumors Completed NCT00929903 Phase 1 pazopanib hydrochloride
6 A Phase I Study of SAHA and Temozolomide in Children With Relapsed or Refractory Primary Brain or Spinal Cord Tumors Completed NCT01076530 Phase 1 vorinostat;temozolomide
7 A Multi-Center Phase Ib Study of Oxaliplatin (NSC #266046) in Combination With Fluorouracil and Leucovorin in Pediatric Patients With Advanced Solid Tumors Completed NCT00281944 Phase 1 oxaliplatin;fluorouracil;leucovorin calcium
8 A PHASE 1/2 STUDY OF RO4929097, AN ORAL SMALL MOLECULE INHIBITOR OF GAMMA-SECRETASE, IN CHILDREN WITH RELAPSED/REFRACTORY SOLID OR CNS TUMORS, LYMPHOMA, OR T-CELL LEUKEMIA Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone

Search NIH Clinical Center for Central Nervous System Germinoma

Genetic Tests for Central Nervous System Germinoma

Anatomical Context for Central Nervous System Germinoma

Organs/tissues related to Central Nervous System Germinoma:

MalaCards : Pineal, Spinal Cord, Brain, Medulla Oblongata, Bone Marrow, Thalamus, Pituitary

Publications for Central Nervous System Germinoma

Articles related to Central Nervous System Germinoma:

(show top 50) (show all 332)
# Title Authors PMID Year
1
Diencephalic syndrome in a female child due to intracranial germinoma: a case report. 62
35507081 2022
2
Factors Influencing Craniospinal Relapse of Intracranial Germinoma After Complete Remission. 62
35842173 2022
3
Intracranial germinoma in the lateral ventricle with polydipsia and polyuria: a case report and literature review. 62
36271932 2022
4
Outcomes of intracranial germinoma-A retrospective multinational Asian study on effect of clinical presentation and differential treatment strategies. 62
34935949 2022
5
Radiographic Findings of an Intracranial Germinoma in a 42-Year-Old Male. 62
36060381 2022
6
Optic Nerve Germinoma and Transient Spontaneous Regression-More Than Meets the Eye. 62
34654758 2022
7
Chemotherapy plus focal radiation therapy for localized intracranial germinoma: How little is enough? 62
35171291 2022
8
Primary central nervous system germinoma as a rare cause of diffuse ependymal involvement in adults. 62
35477521 2022
9
Diagnostic radiation-induced regression of a metastatic primary intracranial germinoma: a case report. 62
30392398 2022
10
Studies on anti-rabphilin-3A antibodies in 15 consecutive patients presenting with central diabetes insipidus at a single referral center. 62
35292721 2022
11
The features of acute lymphocytic leukemia with intracranial germinoma in a patient with Li-Fraumeni syndrome: a case description. 62
35284289 2022
12
Vinblastine monotherapy induction prior to radiotherapy for patients with intracranial germinoma during the COVID-19 pandemic. 62
34520101 2022
13
Value of C-11 methionine PET/CT in patients with intracranial germinoma. 62
35130327 2022
14
Classification of Gliomas and Germinomas of the Basal Ganglia by Transfer Learning. 62
35311111 2022
15
Bifocal lesions have a poorer treatment outcome than a single lesion in adult patients with intracranial germinoma. 62
35231071 2022
16
A Novel Germline SDHA Gene Mutation and Co-Occurring Somatic KIT Activating Mutation in a Patient With Pediatric Central Nervous System Germ Cell Tumor: Case Report. 62
35651799 2022
17
Bilateral Optic Neuropathy Mimicking Neuromyelitis Optica in the Setting of Intracranial Germinoma. 62
34992988 2021
18
Primary intracranial germinoma mimicking meningioma in an elderly patient. 62
33795143 2021
19
Long-Term Outcomes and Sequelae Analysis of Intracranial Germinoma: Need to Reduce the Extended-Field Radiotherapy Volume and Dose to Minimize Late Sequelae. 62
33494128 2021
20
The clinical and imaging features of infratentorial germinomas compared with supratentorial ectopic germinomas. 62
32854527 2021
21
Characteristics of growth disturbances in patients with intracranial germinomas of different origins. 62
34028562 2021
22
Letter to the Editor Regarding "Spontaneous Regression in Intracranial Germinoma: Case Report and Literature Review". 62
34243646 2021
23
Molecular Pathology and Targeted Therapies for Personalized Management of Central Nervous System Germinoma. 62
34357128 2021
24
Primary central nervous system germinoma as a rare cause of diffuse ependymal involvement in adults. 62
34256999 2021
25
Primary intracranial germ cell tumour originating from right brachium Pontis with hypertrophic Olivary degeneration: a case report. 62
34034682 2021
26
[Germinoma in a patient with emaciation and growth retardation. Case report]. 62
33749211 2021
27
Neoadjuvant Chemotherapy and Whole Ventricular Irradiation for Pure Intracranial Germinoma: A Comparison of Three Brain-Sparing Techniques. 62
33824821 2021
28
Diabetes insipidus with impaired vision caused by germinoma and perioptic meningeal seeding: A case report. 62
33748249 2021
29
Radiotherapy-induced glioblastoma: distinct differences in overall survival, tumor location, pMGMT methylation and primary tumor epidemiology in Hong Kong chinese patients. 62
33576706 2021
30
Intracranial Germinoma Misdiagnosed as Hyperthyroidism: A Case Report and Review of the Literature. 62
35140682 2021
31
The radiotherapy utilization rate in pediatric tumors: An analysis of 13,305 patients. 62
33039421 2021
32
A Case of Synchronous Occurrence of Intracranial Germinoma and Systemic Sarcoidosis. 62
35079529 2021
33
Necessity for craniospinal irradiation of germinoma with positive cytology without spinal lesion on MR imaging-A controversy. 62
34355172 2021
34
[Treatment outcomes in patients with central nervous system germinoma (neuro-ophthalmic aspects)]. 62
33560623 2021
35
Induction Chemotherapy Reduces Radiation Therapy Dose and Volume in the Treatment of Intracranial Germinoma: Results of the SMC-G13 Trial. 62
32502506 2020
36
Optimization of Intracranial Germinoma Treatment: Radiotherapy Alone with Reduced Volume and Dose. 62
32434039 2020
37
A Case Report Emphasizing the Importance of Early Diagnosis and Management of Intracranial Germinoma. 62
33391952 2020
38
An Unusual Case of Primary Intracranial Germinoma with Diffuse Subarachnoid Spread Masquerading as Tuberculous Meningitis. 62
33708683 2020
39
Optic atrophy secondary to intracranial germinoma. 62
32167548 2020
40
Giant intracranial germinoma. 62
32737736 2020
41
Pituitary germinomas: a multi-institutional study analyzing patient demographics and management patterns. 62
32388804 2020
42
Pediatric Central Nervous System Germinoma: What Can We Understand From a Worldwide Effort to Maximize Cure and Minimize Risk? 62
32275995 2020
43
A Rare Case of a Pediatric Medullary Intracranial Germinoma. 62
32147555 2020
44
Intracranial Germinoma Masquerading as Secondary Granulomatous Hypophysitis: A Case Report and Review of Literature. 62
31269501 2020
45
Clinical and neuropsychological outcome of pediatric non-midline central nervous system germinoma treated with chemotherapy and reduced dose/volume irradiation: The Children's Hospital Los Angeles experience. 62
31502379 2019
46
Laparoscopic Sleeve Gastrectomy on Severe Obesity after Intracranial Germinoma Treatment: A Case Report. 62
31776301 2019
47
Spontaneous Regression in Intracranial Germinoma: Case Report and Literature Review. 62
31295590 2019
48
Upfront chemotherapy followed by response adaptive radiotherapy for intracranial germinoma: Prospective multicenter cohort study. 62
31319280 2019
49
Primary cavernous sinus germinoma with atypical extension pattern: a case report and review of the literature. 62
30796559 2019
50
De Novo Pineal Region Germinoma in the Seventh Decade of Life: A Case Report. 62
31417835 2019

Variations for Central Nervous System Germinoma

Expression for Central Nervous System Germinoma

Search GEO for disease gene expression data for Central Nervous System Germinoma.

Pathways for Central Nervous System Germinoma

Pathways related to Central Nervous System Germinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
10.52 MIR302C MIR302A

GO Terms for Central Nervous System Germinoma

Molecular functions related to Central Nervous System Germinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA base-pairing translational repressor activity GO:1903231 8.8 MIR371A MIR302C MIR302A

Sources for Central Nervous System Germinoma

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....