MCID: CNT037
MIFTS: 33

Central Nervous System Germinoma

Categories: Cancer diseases, Endocrine diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Central Nervous System Germinoma

MalaCards integrated aliases for Central Nervous System Germinoma:

Name: Central Nervous System Germinoma 12 52 15 71
Germinoma of the Central Nervous System 52 58
Intracranial Germinoma 52 71
Germinoma of Cns 12

Characteristics:

Orphanet epidemiological data:

58
germinoma of the central nervous system
Inheritance: Not applicable; Age of onset: Adolescent,Adult,Childhood;

Classifications:

Orphanet: 58  
Rare neurological diseases
Rare endocrine diseases


External Ids:

Disease Ontology 12 DOID:4438
NCIt 49 C7009
UMLS via Orphanet 72 C1333813
Orphanet 58 ORPHA91352
UMLS 71 C1333813 C1334240

Summaries for Central Nervous System Germinoma

MalaCards based summary : Central Nervous System Germinoma, also known as germinoma of the central nervous system, is related to germinoma and dysgerminoma. An important gene associated with Central Nervous System Germinoma is JMJD1C (Jumonji Domain Containing 1C), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers and Preimplantation Embryo. The drugs Carboplatin and Etoposide have been mentioned in the context of this disorder. Affiliated tissues include brain, pineal and liver.

Related Diseases for Central Nervous System Germinoma

Diseases in the Central Nervous System Germinoma family:

Adult Central Nervous System Germinoma

Diseases related to Central Nervous System Germinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)
# Related Disease Score Top Affiliating Genes
1 germinoma 30.8 POU5F1 MIR302A ALPP
2 dysgerminoma 29.9 POU5F1 MIR302C ALPP
3 endodermal sinus tumor 29.6 POU5F1 MIR302C MIR302A
4 seminoma 29.6 POU5F1 ALPP
5 teratocarcinoma 29.6 POU5F1 MIR302A
6 embryonal carcinoma 29.4 POU5F1 MIR302C MIR302A
7 childhood central nervous system germinoma 12.6
8 adult central nervous system germinoma 12.6
9 teratoma 10.4
10 pituitary hormone deficiency, combined, 2 10.3
11 obstructive hydrocephalus 10.3
12 brain germinoma 10.3
13 ataxia and polyneuropathy, adult-onset 10.2
14 choriocarcinoma 10.2
15 growth hormone deficiency 10.2
16 epidermoid cysts 10.1
17 down syndrome 10.1
18 3-methylglutaconic aciduria, type iii 10.1
19 cauda equina syndrome 10.1
20 testicular yolk sac tumor 10.1
21 testis seminoma 10.1
22 47,xyy 10.1
23 lymphocytic hypophysitis 10.1
24 mixed germ cell tumor 10.1
25 medulloblastoma 10.0
26 meningioma, radiation-induced 10.0
27 meningioma, familial 10.0
28 lymphoma 10.0
29 hydrocephalus 10.0
30 spinal meningioma 10.0
31 neurosarcoidosis 10.0
32 pineoblastoma 10.0
33 glioblastoma multiforme 10.0
34 neurilemmoma 10.0
35 central nervous system cancer 10.0
36 pituitary adenoma 10.0
37 secretory meningioma 10.0
38 lymphoplasmacyte-rich meningioma 10.0
39 hemangioblastoma 10.0
40 pituitary gland disease 10.0
41 pineal region germinoma 10.0
42 hypopituitarism 10.0
43 diabetes insipidus 10.0
44 intracranial hypertension 10.0
45 germ cells tumors 10.0
46 precocious puberty 10.0
47 posttransplant acute limbic encephalitis 10.0
48 rare tumor 10.0
49 gonadoblastoma 10.0 POU5F1 ALPP
50 ovarian germ cell cancer 10.0 POU5F1 MIR302C

Graphical network of the top 20 diseases related to Central Nervous System Germinoma:



Diseases related to Central Nervous System Germinoma

Symptoms & Phenotypes for Central Nervous System Germinoma

Drugs & Therapeutics for Central Nervous System Germinoma

Drugs for Central Nervous System Germinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 57)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Carboplatin Approved Phase 3 41575-94-4 10339178 38904 498142
2
Etoposide Approved Phase 3 33419-42-0 36462
3
Cisplatin Approved Phase 3 15663-27-1 2767 441203 84093
4
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 3 1177-87-3
5
Ondansetron Approved Phase 3 99614-02-5 4595
6
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
7
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
8
Ifosfamide Approved Phase 3 3778-73-2 3690
9 Etoposide phosphate Phase 3
10 Alkylating Agents Phase 3
11 Antiemetics Phase 3
12 Emetics Phase 3
13
Isophosphamide mustard Phase 3 0
14
Bleomycin Approved, Investigational Phase 2 11056-06-7 5360373
15
Thiotepa Approved, Investigational Phase 2 52-24-4 5453
16
Mechlorethamine Approved, Investigational Phase 2 51-75-2 4033
17
Dasatinib Approved, Investigational Phase 1, Phase 2 302962-49-8 3062316
18 Antibiotics, Antitubercular Phase 2
19 Protein Kinase Inhibitors Phase 1, Phase 2
20 Liver Extracts Phase 1, Phase 2
21
Vincristine Approved, Investigational Phase 1 57-22-7, 2068-78-2 5978
22
Sargramostim Approved, Investigational Phase 1 83869-56-1, 123774-72-1
23
Cyclophosphamide Approved, Investigational Phase 1 50-18-0, 6055-19-2 2907
24
Lenograstim Approved, Investigational Phase 1 135968-09-1
25
Acetylcysteine Approved, Investigational Phase 1 616-91-1 12035
26
Mannitol Approved, Investigational Phase 1 69-65-8 6251 453
27
Vitamin A Approved, Nutraceutical, Vet_approved Phase 1 22737-96-8, 68-26-8, 11103-57-4 9904001 445354
28
Imetelstat Investigational Phase 1 868169-64-6
29 Molgramostim Investigational Phase 1 99283-10-0
30 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole Phase 1
31 Analgesics, Non-Narcotic Phase 1
32 Analgesics Phase 1
33 Anti-Inflammatory Agents Phase 1
34 Anti-Inflammatory Agents, Non-Steroidal Phase 1
35
Motesanib diphosphate Phase 1 850649-62-6 11450633
36 Adjuvants, Immunologic Phase 1
37 Tubulin Modulators Phase 1
38 Antimitotic Agents Phase 1
39 Immunosuppressive Agents Phase 1
40 Anti-Bacterial Agents Phase 1
41 Immunologic Factors Phase 1
42 Antirheumatic Agents Phase 1
43 Pharmaceutical Solutions Phase 1
44 Respiratory System Agents Phase 1
45 Antidotes Phase 1
46 Antitubercular Agents Phase 1
47 retinol Phase 1
48 Antioxidants Phase 1
49 Retinol palmitate Phase 1
50 Chelating Agents Phase 1

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Randomized Controlled Trial of Acupressure to Control Chemotherapy-Induced Nausea (CIN) in Children Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
2 SIOP Intracranial Germ Cell Tumours Protocol Completed NCT00293358 Phase 3 carboplatin;cisplatin;etoposide phosphate;ifosfamide
3 Treatment of Intracranial Germinoma With Chemotherapy Prior to Reduced Dose and Volume of Radiotherapy Unknown status NCT02782754 Phase 2 Carboplatin;Etoposide;Cyclophosphamide;Bleomycin
4 Phase II Pre-Irradiation Chemotherapy for Central Nervous System Germ Cell Malignancies Completed NCT00002472 Phase 2 cisplatin;etoposide
5 A Phase II Study To Assess The Ability Of Neoadjuvant Chemotherapy Plus/Minus Second Look Surgery To Eliminate All Measurable Disease Prior To Radiotherapy For NGGCT Completed NCT00047320 Phase 2 carboplatin;etoposide;ifosfamide;thiotepa
6 Dasatinib With Ifosfamide, Carboplatin, Etoposide: A Pediatric Phase I/II Trial Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
7 Phase I and Pharmacokinetic Trial of PTC299 in Pediatric Patients With Refractory or Recurrent CNS Tumors Completed NCT01158300 Phase 1 VEGF inhibitor PTC299
8 A Phase 1 Study of Imetelstat, a Telomerase Inhibitor, in Children With Refractory or Recurrent Solid Tumors and Lymphomas Completed NCT01273090 Phase 1 imetelstat sodium
9 A Pilot Study of Intensive Chemotherapy With Peripheral Stem Cell Support for Infants With Malignant Brain Tumors Completed NCT00003141 Phase 1 carboplatin;cisplatin;cyclophosphamide;etoposide;thiotepa;vincristine sulfate
10 Phase I Dose Escalation Study of N-Acetylcysteine Administered in Conjunction With Carboplatin, Cyclophosphamide, and Etoposide Phosphate BBBD, in Children With Malignant Brain Tumors Terminated NCT00238173 Phase 1 acetylcysteine;carboplatin;cyclophosphamide;etoposide phosphate;mannitol;sodium thiosulfate
11 Evaluation of Cerebral Spinal Fluid (CSF) Proteome and Angiogenesis Proteins in Children With Newly Diagnosed Central Nervous System Tumors Withdrawn NCT00897858

Search NIH Clinical Center for Central Nervous System Germinoma

Genetic Tests for Central Nervous System Germinoma

Anatomical Context for Central Nervous System Germinoma

MalaCards organs/tissues related to Central Nervous System Germinoma:

40
Brain, Pineal, Liver, Bone, Spinal Cord, Medulla Oblongata, Pituitary

Publications for Central Nervous System Germinoma

Articles related to Central Nervous System Germinoma:

(show top 50) (show all 291)
# Title Authors PMID Year
1
A Rare Case of a Pediatric Medullary Intracranial Germinoma. 61
32147555 2020
2
Induction chemotherapy reduces radiotherapy dose and volume in the treatment of intracranial germinoma: Results of the SMC-G13 trial. 61
32502506 2020
3
Pediatric Central Nervous System Germinoma: What Can We Understand From a Worldwide Effort to Maximize Cure and Minimize Risk? 61
32275995 2020
4
Pituitary germinomas: a multi-institutional study analyzing patient demographics and management patterns. 61
32388804 2020
5
Optimization of intracranial germinoma treatment: A single-institution experience with 213 patients supports the use of radiotherapy alone with reduced volume and dose. 61
32434039 2020
6
Optic Atrophy Secondary to Intracranial Germinoma. 61
32167548 2020
7
Intracranial Germinoma Masquerading as Secondary Granulomatous Hypophysitis: A Case Report and Review of Literature. 61
31269501 2020
8
Clinical and neuropsychological outcome of pediatric non-midline central nervous system germinoma treated with chemotherapy and reduced dose/volume irradiation: The Children's Hospital Los Angeles experience. 61
31502379 2019
9
Laparoscopic Sleeve Gastrectomy on Severe Obesity after Intracranial Germinoma Treatment: A Case Report. 61
31776301 2019
10
Spontaneous Regression in Intracranial Germinoma: Case Report and Literature Review. 61
31295590 2019
11
Upfront chemotherapy followed by response adaptive radiotherapy for intracranial germinoma: Prospective multicenter cohort study. 61
31319280 2019
12
Primary cavernous sinus germinoma with atypical extension pattern: a case report and review of the literature. 61
30796559 2019
13
De Novo Pineal Region Germinoma in the Seventh Decade of Life: A Case Report. 61
31417835 2019
14
A Central Role of Radiation Therapy in Central Nervous System Germinoma. 61
31327428 2019
15
Redefining Ventricular Target Volume in Germinoma: Is Inclusion of Temporal Horns Necessary? 61
30940528 2019
16
Rapid, label-free detection of intracranial germinoma using multiphoton microscopy. 61
31572743 2019
17
Treatment outcomes of intracranial germinoma: a retrospective analysis of 170 patients from a single institution. 61
30209611 2019
18
Re-irradiation for Paediatric Tumours. 61
30385005 2019
19
Bifocal germinoma in a patient with 16p11.2 microdeletion syndrome. 61
30738016 2019
20
A synchronous occurrence of bifocal intracranial germinoma and bilateral testicular epidermoid cyst in an adolescent patient with Klinefelter`s syndrome. 61
31916730 2019
21
Treatment outcomes based on radiation therapy fields for bifocal germinoma: Synchronous or disseminated disease? 61
31581215 2019
22
Diagnostic radiation-induced regression of a metastatic primary intracranial germinoma: a case report. 61
30392398 2018
23
Secondary glioblastoma after treatment of intracranial germinoma - would radiation-only therapy still be safe? Case report. 61
30445947 2018
24
Placental alkaline phosphatase levels in cerebrospinal fluid can have a decisive role in the differential diagnosis of intracranial germ cell tumors. 61
30265190 2018
25
High-dose chemotherapy with autologous stem cell transplantation spares re-irradiation for recurrent intracranial germinoma. 61
29693779 2018
26
Intracranial germinoma causing cerebral haemiatrophy and hypopituitarism. 61
29378909 2018
27
Widespread Intra-abdominal Carcinomatosis from a Rhabdoid Meningioma after Placement of a Ventriculoperitoneal Shunt: A Case Report and Review of the Literature. 61
29682040 2018
28
Practice patterns and survival outcomes of intracranial germinoma: an analysis of the National Cancer Database. 61
29177595 2018
29
Widespread Intra-abdominal Carcinomatosis from a Rhabdoid Meningioma after Placement of a Ventriculoperitoneal Shunt: A Case Report and Review of the Literature. 61
29492156 2018
30
Clinical case seminar: Familial intracranial germinoma. 61
30379323 2018
31
PD-1/PD-L1 expression in a series of intracranial germinoma and its association with Foxp3+ and CD8+ infiltrating lymphocytes. 61
29617441 2018
32
A rare case report and literatures review on primary germinoma in cerebellar hemisphere. 61
28689343 2017
33
Visual complaints in intracranial germinomas. 61
28436607 2017
34
Intracranial Germinoma: Systemic Chemotherapy in Addition to Dose-Reduced Radiation Therapy. 61
28614087 2017
35
Radiotherapy and chemotherapy plus radiation in the treatment of patients with pure intracranial germinoma: A meta-analysis. 61
28602629 2017
36
Pediatric intracranial germinoma: use chemotherapy first. 61
29044451 2017
37
Adipsic diabetes insipidus revealing a bifocal intracranial germinoma. 61
28483362 2017
38
Anomalous intracranial germinoma with unilateral cerebral peduncle swelling. 61
28283777 2017
39
Craniospinal irradiation using helical tomotherapy for central nervous system tumors. 61
28096196 2017
40
Efficacy of Ifosfamide-Cisplatin-Etoposide (ICE) Chemotherapy for a CNS Germinoma in a Child With Down Syndrome. 61
27879538 2017
41
Atypical major depressive episode as initial presentation of intracranial germinoma in a male adolescent. 61
28053535 2017
42
[Biomarker of the intracranial germinoma -New tumor marker'PLAP for the intracranial germinoma-]. 61
30634789 2016
43
Ectopic intracranial germinoma. 61
27050919 2016
44
Basal Ganglia Germinoma in an Adult. 61
27241091 2016
45
Proton Therapy in Children: A Systematic Review of Clinical Effectiveness in 15 Pediatric Cancers. 61
27084646 2016
46
Brain dose-sparing radiotherapy techniques for localized intracranial germinoma: Case report and literature review of modern irradiation. 61
27080575 2016
47
Preservation of KIT genotype in a novel pair of patient-derived orthotopic xenograft mouse models of metastatic pediatric CNS germinoma. 61
26956263 2016
48
Outcomes of children with central nervous system germinoma treated with multi-agent chemotherapy followed by reduced radiation. 61
26744133 2016
49
The necessity of long-term follow-up including spinal examination after successful initial treatment of intracranial germinoma: case reports. 61
26351071 2016
50
Determining an Optimal Cutoff of Serum β-Human Chorionic Gonadotropin for Assisting the Diagnosis of Intracranial Germinomas. 61
26771195 2016

Variations for Central Nervous System Germinoma

Expression for Central Nervous System Germinoma

Search GEO for disease gene expression data for Central Nervous System Germinoma.

Pathways for Central Nervous System Germinoma

Pathways related to Central Nervous System Germinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.28 POU5F1 ALPP
2 10.73 POU5F1 MIR302A
3 10.2 MIR302C MIR302A

GO Terms for Central Nervous System Germinoma

Sources for Central Nervous System Germinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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