Central Nervous System Germinoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CNT037 MIFTS: 31	Central Nervous System Germinoma Categories: Cancer diseases, Endocrine diseases, Neuronal diseases, Rare diseases
Genes Tissues Related diseases Publications Pathways Drugs Expand all tables

Sources

Aliases & Classifications for Central Nervous System Germinoma

MalaCards integrated aliases for Central Nervous System Germinoma:

Name: Central Nervous System Germinoma ¹² ²⁰ ¹⁵ ⁷⁰

Germinoma of the Central Nervous System ²⁰ ⁵⁸

Intracranial Germinoma ²⁰ ⁷⁰

Germinoma of Cns ¹²

Characteristics:

Orphanet epidemiological data:

⁵⁸

germinoma of the central nervous system
Inheritance: Not applicable; Age of onset: Adolescent,Adult,Childhood;

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Neuronal diseases Endocrine diseases

See all MalaCards categories (disease lists)

Orphanet: ⁵⁸

Rare neurological diseases

Rare endocrine diseases

External Ids:

Disease Ontology ¹² DOID:4438

NCIt ⁵⁰ C7009

UMLS via Orphanet ⁷¹ C1333813

Orphanet ⁵⁸ ORPHA91352

UMLS ⁷⁰ C1333813 C1334240

Sources

Summaries for Central Nervous System Germinoma

MalaCards based summary : Central Nervous System Germinoma, also known as germinoma of the central nervous system, is related to germinoma and dysgerminoma. An important gene associated with Central Nervous System Germinoma is JMJD1C (Jumonji Domain Containing 1C), and among its related pathways/superpathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Preimplantation Embryo. The drugs Etoposide and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include pituitary, pineal and testis.

Sources

Related Diseases for Central Nervous System Germinoma

Diseases in the Central Nervous System Germinoma family:

Adult Central Nervous System Germinoma

Diseases related to Central Nervous System Germinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 111)

#	Related Disease	Score	Top Affiliating Genes
1	germinoma	30.9	POU5F1 MIR302A ALPP
2	dysgerminoma	30.1	MIR302C ALPP
3	seminoma	30.0	POU5F1 ALPP
4	dysgerminoma of ovary	30.0	POU5F1 ALPP
5	embryonal carcinoma	29.7	POU5F1 MIR302A
6	endodermal sinus tumor	29.6	MIR302C MIR302A ALPP
7	childhood central nervous system germinoma	11.5
8	adult central nervous system germinoma	11.4
9	diabetes insipidus	10.5
10	germ cells tumors	10.4
11	pituitary hormone deficiency, combined, 2	10.3
12	teratoma	10.3
13	brain germinoma	10.3
14	obstructive hydrocephalus	10.2
15	ataxia and polyneuropathy, adult-onset	10.1
16	growth hormone deficiency	10.1
17	medulloblastoma	10.1
18	meningioma, familial	10.1
19	lymphoma	10.1
20	intracranial meningioma	10.1
21	hydrocephalus	10.1
22	papilledema	10.1
23	pineoblastoma	10.1
24	glioblastoma	10.1
25	nervous system cancer	10.1
26	neurilemmoma	10.1
27	central nervous system cancer	10.1
28	pituitary adenoma	10.1
29	secretory meningioma	10.1
30	lymphoplasmacyte-rich meningioma	10.1
31	hemangioblastoma	10.1
32	pituitary gland disease	10.1
33	pineal region germinoma	10.1
34	hypopituitarism	10.1
35	precocious puberty	10.1
36	epidermoid cysts	10.0
37	down syndrome	10.0
38	cauda equina syndrome	10.0
39	choriocarcinoma	10.0
40	testicular yolk sac tumor	10.0
41	testis seminoma	10.0
42	47,xyy	10.0
43	lymphocytic hypophysitis	10.0
44	headache	10.0
45	mixed germ cell tumor	10.0
46	gonadoblastoma	10.0	POU5F1 ALPP
47	spermatocytoma	10.0	POU5F1 CT45A1
48	malignant teratoma	10.0	POU5F1 MIR302C
49	testicular disease	9.9	POU5F1 MIR302A
50	choledocholithiasis	9.9	MIR302C ALPP

Graphical network of the top 20 diseases related to Central Nervous System Germinoma:

Sources

Symptoms & Phenotypes for Central Nervous System Germinoma

Sources

Drugs & Therapeutics for Central Nervous System Germinoma

Drugs for Central Nervous System Germinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Etoposide

Approved

Phase 2

33419-42-0

36462

Synonyms:

(−)-etoposide

(-)-Etoposide

121471-01-0

136598-18-0

201594-04-9

33419-42-0

35317-32-9

4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-b-D-glucopyranoside)

4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-beta-D-glucopyranoside)

4'-Demethylepipodophyllotoxin 9-(4,6-O-(R)-ethylidene-β-D-glucopyranoside)

4'-Demethylepipodophyllotoxin 9-(4,6-O-ethylidene-beta-D-glucopyranoside)

4'-Demethyl-epipodophyllotoxin 9-[4,6-O-(R)-ethylidene-beta-D-glucopyranoside

4-Demethylepipodophyllotoxin b-D-ethylideneglucoside

4-Demethylepipodophyllotoxin beta-D-ethylideneglucoside

4'-Demethylepipodophyllotoxin ethylidene-.beta.-D-glucoside

4-demethylepipodophyllotoxin β-D-ethylideneglucoside

4-Demethylepipodophyllotoxin β-D-ethylideneglucoside

4-Demethylepipodophyllotoxin-.beta.-D-ethylideneglucoside

4'-O-Demethyl-1-O-(4,6-O-ethylidene-beta-D-glucopyranosyl)epipodophyllotoxin

51854-34-3

76576-58-4

9-((4,6-O-Ethylidine-b-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-D)-1,3-dioxol-6(5ah)-one

9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-d)-1,3-dioxol-6(5aH)-one

9-((4,6-O-Ethylidine-beta-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-D)-1,3-dioxol-6(5ah)-one

9-((4,6-O-Ethylidine-β-D-glucopyranosyl)oxy)-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,4-dimethyloxyphenyl)furo(3',4'':6,7)naptho-(2,3-D)-1,3-dioxol-6(5ah)-one

AB00438905

AC1L1FN8

AC1L1VT3

AC1L6246

AC1NR4OG

AC1O4WGG

AC1O7M1N

AC1Q47JJ

alpha-D-Glucopyranosyl isomer etoposide

Ambap33419-42-0

Baxter brand OF etoposide

Baxter oncology brand OF etoposide

Bio1_000489

Bio1_000978

Bio1_001467

BPBio1_000673

BRD-K37798499-001-02-5

Bristol myers brand OF etoposide

Bristol myers squibb brand OF etoposide

Bristol-myers brand OF etoposide

Bristol-myers squibb brand OF etoposide

BSPBio_000611

C01576

CCRIS 2392

Celltop

CHEBI:4911

CHEBI:588795

CHEMBL44657

CID11758093

CID284997

CID3310

CID36462

CID5284558

CID6419930

CID6610299

CPD000112002

D00125

DB00773

DEMETHY-EPIPODOPHYLLOTOXIN,ETHYLIDENE GLUCOSIDE,

Demethyl epipodophyllotoxin ethylidine glucoside

Demethyl Epipodophyllotoxin Ethylidine Glucoside

Demethyl-epiodophyllotoxin ethylidene glucoside

Demethylepipodophyllotoxin-beta-D-ethylideneglucoside

E0675

E1383_SIGMA

EINECS 251-509-1

Epipodophyllotoxin VP-16213

Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-.beta.-D-glucopyranoside

Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-beta-D-glucopyranoside

Epipodophyllotoxin, 4'-demethyl-, 4,6-O-ethylidene-beta-D-glucopyranoside (8CI)

Epipodophyllotoxin, 4'-demethyl-, 9-(4,6-O-ethylidene-.beta.-D-glucopyranoside)

Epipodophyllotoxin, 4'-demethyl-, 9-(4,6-O-ethylidene-beta-D-glucopyranoside)

Eposide

Eposin

Eposin, Vepesid, VP-16, Toposar, Etoposide

Eto gry

Eto-gry

Etomedac

ETOP

Etopol

Etopophos

Etopophos (phosphate salt)

Etopos

etoposide

Etoposide

Etoposide (JP15/USP/INN)

Etoposide (VP16)

Etoposide [USAN:INN:BAN:JAN]

Etoposide pierre fabre

Etoposide teva

Etoposide, (5a alpha)-isomer

Etoposide, (5a alpha,9 alpha)-isomer

Etoposide, (5S)-isomer

Etoposide, alpha D glucopyranosyl isomer

Etoposide, alpha-D-glucopyranosyl isomer

Etoposido

Etoposido [INN-Spanish]

Etoposido ferrer farma

Etoposidum

Etoposidum [INN-Latin]

Etosid

Exitop

Ferrer brand OF etoposide

Gry brand OF etoposide

HMS1569O13

HMS2052N05

HMS2089F14

HSDB 6517

I06-0248

KBioSS_002410

Lastet

Lemery brand OF etoposide

LS-1214

Medac brand OF etoposide

MLS000049957

MLS001074951

MLS001424283

MLS002153463

MLS002207239

MLS002222184

MolPort-003-983-431

MolPort-004-905-001

MolPort-004-955-161

NCGC00025056-02

NChemBio.2007.10-comp19

nchembio.573-comp8

nchembio873-comp2

NK 171

Novartis brand OF etoposide

NSC 141540

NSC141540

NSC-141540

Onkoposid

Onkoworks brand OF etoposide

Pharmachemie brand OF etoposide

Pierre fabre brand OF etoposide

Prasfarma brand OF etoposide

Prestwick_211

Prestwick0_000396

Prestwick1_000396

Prestwick2_000396

Prestwick3_000396

Riboposid

Ribosepharm brand OF etoposide

S1225_Selleck

SAM001246880

Sanfer brand OF etoposide

SMR000112002

SPBio_002532

ST056353

Tedec meiji brand OF etoposide

Teva brand OF etoposide

Teva, etoposide

Toposar

trans-Etoposide

UNII-6PLQ3CP4P3

Vepesid

VePesid

VePESID (TN)

Vepesid J

Vepeside

Vépéside sandoz

Vépéside-sandoz

VP 16

VP 16 (pharmaceutical)

VP 16213

VP 16-213

VP-16

VP-16-213

ZINC03830818

ZINC03938684

Zuyeyidal

Cyclophosphamide

Approved, Investigational

Phase 2

50-18-0, 6055-19-2

2907

Synonyms:

(-)-Cyclophosphamide

(+-)-Cyclophosphamide

(+,-)-2-(Bis(2-chloroethyl)amino)tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide monohydrate

(RS)-Cyclophosphamide

1-(bis(2-chloroethyl)amino)-1-oxo-2-aza-5-oxaphosphoridine

1-Bis(2-chloroethyl)amino-1-oxo-2-aza-5-oxaphosphoridin

2-[Bis(2-chloroethylamino)]-tetrahydro-2H-1,3,2-oxazaphosphorine-2-oxide

4-Hydroxy-cyclophosphan-mamophosphatide

50-18-0

60007-95-6

6055-19-2 (monohydrate)

75526-90-8

AC1L1EQQ

AI3-26198

Anhydrous cyclophosphamide

Anhydrous, cyclophosphamide

ASTA

Asta B 518

ASTA B518

B 518

B-518

bis(2-Chloroethyl)phosphami de cyclic propanolamide

bis(2-Chloroethyl)phosphamide cyclic propanolamide ester

Bis(2-chloroethyl)phosphoramide cyclic propanolamide ester

BRN 0011744

BSPBio_002099

C 0768

C07888

C7H15Cl2N2O2P

CB 4564

CB-4564

CCRIS 188

CHEBI:4027

CHEMBL32520

CHEMBL88

Ciclofosfamida

Ciclofosfamida [INN-Spanish]

Ciclofosfamide

Ciclophosphamide

Ciclophosphamide [INN]

CID2907

Clafen

Claphene

CPA

CTX

Cycloblastin

Cyclophosphamid

cyclophosphamide

Cyclophosphamide

Cyclophosphamide (anhydrous form)

Cyclophosphamide (anhydrous)

Cyclophosphamide (INN)

Cyclophosphamide (TN)

Cyclophosphamide anhydrous

Cyclophosphamide monohydrate

Cyclophosphamide Monohydrate

Cyclophosphamide Sterile

Cyclophosphamide, (+-)-Isomer

Cyclophosphamide, (R)-isomer

Cyclophosphamide, (S)-isomer

Cyclophosphamides

Cyclophosphamidum

Cyclophosphamidum [INN-Latin]

Cyclophosphan

Cyclophosphane

Cyclophosphanum

Cyclophosphoramide

Cyclostin

Cyklofosfamid

Cyklofosfamid [Czech]

Cytophosphan

Cytophosphane

Cytoxan

Cytoxan (TN)

Cytoxan Lyoph

D,L-Cyclophosphamide

D07760

DB00531

DivK1c_000246

EINECS 200-015-4

Endoxan

Endoxan R

Endoxana

Endoxanal

Endoxan-Asta

Endoxane

Enduxan

EU-0100238

Genoxal

Hexadrin

HMS2090A12

HSDB 3047

IDI1_000246

KBio1_000246

KBio2_001338

KBio2_003906

KBio2_006474

KBio3_001319

KBioGR_000888

KBioSS_001338

Lopac0_000238

Lopac-C-0768

LS-1302

LS-99787

Lyophilized Cytoxan

Mitoxan

MolPort-001-783-420

Monohydrate, cyclophosphamide

N,N-Bis(2-chloroethyl)-1,3,2-oxazaphosphinan-2-amine 2-oxide

N,N-Bis(2-chloroethyl)tetrahydro-2H-1,3,2-oxazaphosphorin-2-amine 2-oxide

NCGC00015209-01

NCGC00015209-03

NCGC00015209-06

NCGC00091741-02

NCGC00091741-03

NCI60_002097

NCI-C04900

Neosar

NINDS_000246

NSC 26271

NSC26271

NSC-26271

NSC273033

NSC273034

Occupation, cyclophosphamide exposure

Procytox

RCRA waste no. U058

Rcra waste number U058

Rcra Waste Number U058

Revimmune

S1217_Selleck

Semdoxan

Sendoxan

Senduxan

SK 20501

SPBio_001071

Spectrum_000858

Spectrum2_001146

Spectrum3_000370

Spectrum4_000304

Spectrum5_000795

STK177249

STOCK2S-91217

UNII-6UXW23996M

WLN: T6MPOTJ BO BN2G2G

Zyklophosphamid

Zyklophosphamid [German]

Bleomycin

Approved, Investigational

Phase 2

11056-06-7

5360373

Synonyms:

(betaR)-N(alpha)-{[6-amino-2-((1S)-3-amino-1-{[(2S)-2,3-diamino-3-oxopropyl]amino}-3-oxopropyl)-5-methylpyrimidin-4-yl]carbonyl}-beta-{2-O-[3-O-(aminocarbonyl)-alpha-D-mannopyranosyl]-alpha-L-gulopyranosyloxy}-N-[(1R,2S,3S)-5-({(1S,2R)-1-[({2-[4-({[3-(dimethylsulfonio)propyl]amino}carbonyl)-2,4'-bi-1,3-thiazol-2'-yl]ethyl}amino)carbonyl]-2-hydroxypropyl}amino)-3-hydroxy-4-methyl-5-oxopentan-2-yl]-L-histidinamide

11056-06-7

11116-31-7

1400-95-9

3-[[2-[2-[2-[[(2S,3R)-2-[[(2S,3S,4R)-4-[[(2S)-2-[[6-amino-2-[(1S)-3-amino-1-[[(2S)-2,3-diamino-3-oxopropyl]amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2R,3S,4S,5S,6S)-3-[(2R,3S,4S,5R,6R)-4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxy-2-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]ethyl]-1,3-thiazol-4-yl]-1,3-thiazole-4-carbonyl]amino]propyl-dimethylsulfanium

3-[[2-[2-[2-[[(2S,3R)-2-[[(2S,3S,4R)-4-[[(2S,3R)-2-[[6-amino-2-[(1S)-3-amino-1-[[(2S)-2,3-diamino-3-oxopropyl]amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2R,3S,4S,5S,6S)-3-[(2R,3S,4S,5R,6R)-4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxy-2-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]ethyl]-1,3-thiazol-4-yl]-1,3-thiazole-4-carbonyl]amino]propyl-dimethylsulfanium

3-[[2-[2-[2-[[(2S,3R)-2-[[(2S,3S,4R)-4-[[(2S,3R)-2-[[6-amino-2-[(1S)-3-amino-1-[[(2S)-2,3-diamino-3-oxopropyl]amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[3-[4-carbamoyloxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxy-2-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]ethyl]-1,3-thiazol-4-yl]-1,3-thiazole-4-carbonyl]amino]propyl-dimethylsulfanium

37208-04-1

37293-16-6

37353-43-8

9041-93-4

9041-93-4 (sulfate (salt))

AC1L9UFF

AC1NSEJD

AC1NUTOQ

Almirall brand OF bleomycin sulfate

Bellon brand OF bleomycin sulfate

Bellon, bléomycine

Blanoxan

Blenoxane

Bleo

Bleo cell

Bleo-cell

BLEOcell

Bleocin

Bleogin

Bleolem

Bleomicin

Bleomicina

Bleomicina [INN-Spanish]

bleomycin

Bleomycin

Bleomycin a(2)

Bleomycin A(2)

bleomycin a2

Bleomycin a2

Bleomycin A2

Bleomycin A2 & Bleomycin B2.

Bleomycin b(2)

Bleomycin B(2)

Bleomycin b2

Bleomycin B2

Bleomycin sulfate

Bleomycin sulphate

Bleomycine

Bleomycine [INN-French]

Bléomycine bellon

Bleomycins

Bleomycinum

Bleomycinum [INN-Latin]

Bleomycinum mack

BLM

Bristol myers squibb brand OF bleomycin sulfate

Bristol-myers squibb brand OF bleomycin sulfate

Bull brand OF bleomycin sulfate

C06854

C55H85N17O21S3

C55H86N17O21S3

CCRIS 2754

Cell pharm brand OF bleomycin sulfate

CHEBI:3139

CHEMBL403664

CID456190

CID5360373

CID5460769

DB00290

EINECS 234-356-5

HSDB 3208

Lemery brand OF bleomycin sulfate

LMPK14000006

LS-44860

LS-524

Lundbeck brand OF bleomycin sulfate

Mack brand OF bleomycin sulfate

Mack, bleomycinum

N(1)-[3-(dimethylsulfonio)propyl]bleomycinamide

N1-(3-(Dimethylsulfonio)propyl)bleomycinamide

NDC 0015-3010

NSC 125066

Pingyangmyvin A2

STOCK1N-74760

Sulfate, bleomycin

UNII-13M89UEA7W

UNII-40S1VHN69B

Zhengguangmycin A2

Zhengguangmycin A2 [Chinese]

Carboplatin

Approved

Phase 2

41575-94-4

10339178 498142 38904

Synonyms:

(SP-4-2)-diammine[cyclobutane-1,1-dicarboxylato(2-)-kappa(2)O,O']platinum

/h1-3H2,(H,7,8)(H,9,10)

1,1-Cyclobutanedicarboxylate diammine platinum (II)

1,1-Cyclobutanedicarboxylate diammine platinum(II)

2*-1

2*1H2

41575-94-4

70903-55-8

AC-1457

AC1L8I6U

Ambap41575-94-4

azanide

Blastocarb

BSPBio_003145

C 2538

C2043

C2538_SIGMA

C6H10N2O4Pt

Carbopaltin

Carboplat

carboplatin

Carboplatin

Carboplatin (JAN/USP/INN)

Carboplatin (USAN)

Carboplatin [USAN:INN:BAN:JAN]

Carboplatine

Carboplatine [French]

Carboplatino

Carboplatino [Spanish]

Carboplatinum

Carboplatinum [Latin]

Carbosin

Carbotec

Cbdca

CBDCA

CCRIS 3404

CHEBI:31355

CHEMBL1351

CHEMBL288376

CID10339178

CID2567

CID38904

CID426756

CID498142

CID5352133

CID6398587

CID6603770

cis -Diammine[1,1-cyclobutane-dicarboxylato] platinum

cis-(1,1-cyclobutanedicarboxylato)diammineplatinum(II)

cis-(1,1-Cyclobutanedicarboxylato)diammineplatinum(II)

cis-Diamine(1,1-cyclobutanedicarboxylato)platinum(II)

cis-Diamine[1,1-cyclobutanedicarboxylato]platinum(II)

cis-Diammine(1,1-cyclobutanedicarboxylato) platinum

cis-diammine(1,1-cyclobutanedicarboxylato)platinum

cis-Diammine(1,1-cyclobutanedicarboxylato)platinum

cis-diammine(1,1-cyclobutanedicarboxylato)platinum(II)

cis-Diammine(1,1-cyclobutanedicarboxylato)platinum(II)

cis-Diammine(cyclobutanedicarboxylato)platinum II

Cyclobutane-1,1-dicarboxylate

cyclobutane-1,1-dicarboxylic acid

D01363

DB00958

Diammine(1,1-cyclobutanedicarboxylato)platinum (II)

Diammine(cyclobutane-1,1-dicarboxylato(2-)-O,O')platinum

diammine[cyclobutane-1,1-dicarboxylato(2-)-k2O1,O1]platinum

Diammine-1,1-cyclobutane dicarboxylate platinum II

DivK1c_000892

EINECS 255-446-0

Ercar

EU-0100230

HMS1921J16

HMS2090M05

HMS2092B22

HMS502M14

HSDB 6957

I14-2390

IDI1_000892

InChI=1/C6H8O4.2H2N.Pt/c7-4(8)6(5(9)10)2-1-3-6

IUPAC: Azane

JM 8

JM8

JM-8

KBio1_000892

KBio2_002009

KBio2_004577

KBio2_007145

KBio3_002645

KBioGR_000713

KBioSS_002009

Lopac0_000230

Lopac-C-2538

LS-117689

MolPort-003-665-501

MolPort-003-845-609

NCGC00015223-01

NCGC00093695-01

NCGC00094961-01

NCGC00094961-02

NCGC00094961-03

NCGC00162099-01

NCGC00162099-02

NCGC00167800-01

NCGC00178242-01

nchembio.573-comp10

nchembio773-comp2

nchembio873-comp3

Nealorin

Neocarbo

NINDS_000892

NSC 201345

NSC 241240

NSC201345

NSC241240

NSC-241240

Paraplatin

Paraplatin (TN)

Paraplatin, Carboplatin

Paraplatin-AQ

Platinum(+2) Cation

platinum(2+)

Platinum(II), (1, 1-cyclobutanedicar

Platinum, {diammine[1,1-cyclobut

Platinum, diammine(1,1-cyclobutanedicarboxylato(2-)-O,O')-, (SP-4-2)

Ribocarbo

S1215_Selleck

SPBio_000716

Spectrum_001529

SPECTRUM1502106

Spectrum2_000898

Spectrum3_001503

Spectrum4_000337

Spectrum5_001094

UNII-BG3F62OND5

Antirheumatic Agents

Phase 2

Immunosuppressive Agents

Phase 2

Etoposide phosphate

Phase 2

Antibiotics, Antitubercular

Phase 2

Alkylating Agents

Phase 2

Anti-Bacterial Agents

Phase 2

Immunologic Factors

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Treatment of Intracranial Germinoma With Chemotherapy Prior to Reduced Dose and Volume of Radiotherapy	Unknown status	NCT02782754	Phase 2	Carboplatin;Etoposide;Cyclophosphamide;Bleomycin

Search NIH Clinical Center for Central Nervous System Germinoma

Sources

Genetic Tests for Central Nervous System Germinoma

Sources

Anatomical Context for Central Nervous System Germinoma

MalaCards organs/tissues related to Central Nervous System Germinoma:

⁴⁰

Pituitary, Pineal, Testis, Spinal Cord, Medulla Oblongata, Bone Marrow, Brain

Sources

Publications for Central Nervous System Germinoma

Articles related to Central Nervous System Germinoma:

(show top 50) (show all 302)

#	Title	Authors	PMID	Year
1	[Germinoma in a patient with emaciation and growth retardation. Case report]. ⁶¹	Ciucio AY...Schenone N	33749211	2021
2	Primary intracranial germinoma mimicking meningioma in an elderly patient. ⁶¹	Jacques A...Ducray F	33795143	2021
3	Diabetes insipidus with impaired vision caused by germinoma and perioptic meningeal seeding: A case report. ⁶¹	Yang N...Zhang HB	33748249	2021
4	Radiotherapy-induced glioblastoma: distinct differences in overall survival, tumor location, pMGMT methylation and primary tumor epidemiology in Hong Kong chinese patients. ⁶¹	Woo PYM...Poon WS	33576706	2021
5	[Treatment outcomes in patients with central nervous system germinoma (neuro-ophthalmic aspects)]. ⁶¹	Serova NK...Trunin YY	33560623	2021
6	The radiotherapy utilization rate in pediatric tumors: An analysis of 13,305 patients. ⁶¹	Bishr MK...Mousa AG	33039421	2021
7	Long-Term Outcomes and Sequelae Analysis of Intracranial Germinoma: Need to Reduce the Extended-Field Radiotherapy Volume and Dose to Minimize Late Sequelae. ⁶¹	Lee JH...Kim IH	33494128	2021
8	Optimization of Intracranial Germinoma Treatment: Radiotherapy Alone with Reduced Volume and Dose. ⁶¹	Byun HK...Suh CO	32434039	2020
9	Induction Chemotherapy Reduces Radiation Therapy Dose and Volume in the Treatment of Intracranial Germinoma: Results of the SMC-G13 Trial. ⁶¹	Lee JW...Shin HJ	32502506	2020
10	A Case Report Emphasizing the Importance of Early Diagnosis and Management of Intracranial Germinoma. ⁶¹	Ram N...Mushtaq N	33391952	2020
11	An Unusual Case of Primary Intracranial Germinoma with Diffuse Subarachnoid Spread Masquerading as Tuberculous Meningitis. ⁶¹	Sharma AK...Saran RK	33708683	2020
12	Optic atrophy secondary to intracranial germinoma. ⁶¹	Lee WA...Liao IC	32167548	2020
13	Giant intracranial germinoma. ⁶¹	Hidalgo J...Cohen AR	32737736	2020
14	The clinical and imaging features of infratentorial germinomas compared with supratentorial ectopic germinomas. ⁶¹	Li W...Ma J	32854527	2020
15	Pituitary germinomas: a multi-institutional study analyzing patient demographics and management patterns. ⁶¹	Bhimani AD...Mehta AI	32388804	2020
16	A Rare Case of a Pediatric Medullary Intracranial Germinoma. ⁶¹	Seifert K...Malhotra A	32147555	2020
17	Pediatric Central Nervous System Germinoma: What Can We Understand From a Worldwide Effort to Maximize Cure and Minimize Risk? ⁶¹	Hill-Kayser CE...Breneman J	32275995	2020
18	Intracranial Germinoma Masquerading as Secondary Granulomatous Hypophysitis: A Case Report and Review of Literature. ⁶¹	Pal R...Dutta P	31269501	2020
19	Clinical and neuropsychological outcome of pediatric non-midline central nervous system germinoma treated with chemotherapy and reduced dose/volume irradiation: The Children's Hospital Los Angeles experience. ⁶¹	Yeo KK...Dhall G	31502379	2019
20	Laparoscopic Sleeve Gastrectomy on Severe Obesity after Intracranial Germinoma Treatment: A Case Report. ⁶¹	Nezu M...Satoh F	31776301	2019
21	Spontaneous Regression in Intracranial Germinoma: Case Report and Literature Review. ⁶¹	Zhang S...Ju Y	31295590	2019
22	Upfront chemotherapy followed by response adaptive radiotherapy for intracranial germinoma: Prospective multicenter cohort study. ⁶¹	Lee DS...Kim DS	31319280	2019
23	Primary cavernous sinus germinoma with atypical extension pattern: a case report and review of the literature. ⁶¹	Sakakura K...Matsumura A	30796559	2019
24	De Novo Pineal Region Germinoma in the Seventh Decade of Life: A Case Report. ⁶¹	Sano M...Fujii Y	31417835	2019
25	A Central Role of Radiation Therapy in Central Nervous System Germinoma. ⁶¹	Bitterman DS...Haas-Kogan DA	31327428	2019
26	Rapid, label-free detection of intracranial germinoma using multiphoton microscopy. ⁶¹	Fang N...Chen J	31572743	2019
27	Redefining Ventricular Target Volume in Germinoma: Is Inclusion of Temporal Horns Necessary? ⁶¹	Yan M...Tsang DS	30940528	2019
28	Treatment outcomes of intracranial germinoma: a retrospective analysis of 170 patients from a single institution. ⁶¹	Lian X...Zhang F	30209611	2019
29	Re-irradiation for Paediatric Tumours. ⁶¹	Tsang DS...Laperriere NJ	30385005	2019
30	Bifocal germinoma in a patient with 16p11.2 microdeletion syndrome. ⁶¹	Ventura M...Carrilho F	30738016	2019
31	A synchronous occurrence of bifocal intracranial germinoma and bilateral testicular epidermoid cyst in an adolescent patient with Klinefelter`s syndrome. ⁶¹	Ozyoruk D...Gunes A	31916730	2019
32	Treatment outcomes based on radiation therapy fields for bifocal germinoma: Synchronous or disseminated disease? ⁶¹	Chung SY...Suh CO	31581215	2019
33	Secondary glioblastoma after treatment of intracranial germinoma - would radiation-only therapy still be safe? Case report. ⁶¹	Hwang K...Kim CY	30445947	2018
34	Diagnostic radiation-induced regression of a metastatic primary intracranial germinoma: a case report. ⁶¹	Woo PYM...Chan KY	30392398	2018
35	Placental alkaline phosphatase levels in cerebrospinal fluid can have a decisive role in the differential diagnosis of intracranial germ cell tumors. ⁶¹	Aihara Y...Kawamata T	30265190	2018
36	Intracranial germinoma causing cerebral haemiatrophy and hypopituitarism. ⁶¹	Guedes BF...Simabukuro MM	29378909	2018
37	High-dose chemotherapy with autologous stem cell transplantation spares re-irradiation for recurrent intracranial germinoma. ⁶¹	Kubota H...Adachi S	29693779	2018
38	Widespread Intra-abdominal Carcinomatosis from a Rhabdoid Meningioma after Placement of a Ventriculoperitoneal Shunt: A Case Report and Review of the Literature. ⁶¹	Ng JJ...Yeo TT	29682040	2018
39	Practice patterns and survival outcomes of intracranial germinoma: an analysis of the National Cancer Database. ⁶¹	Wang WG...Chinnaiyan P	29177595	2018
40	PD-1/PD-L1 expression in a series of intracranial germinoma and its association with Foxp3+ and CD8+ infiltrating lymphocytes. ⁶¹	Liu B...Miyamoto S	29617441	2018
41	Widespread Intra-abdominal Carcinomatosis from a Rhabdoid Meningioma after Placement of a Ventriculoperitoneal Shunt: A Case Report and Review of the Literature. ⁶¹	Jun Jie NG...Yeo TT	29492156	2018
42	Clinical case seminar: Familial intracranial germinoma. ⁶¹	Doknic M...Grujicic D	30379323	2018
43	A rare case report and literatures review on primary germinoma in cerebellar hemisphere. ⁶¹	Wang L...Gong J	28689343	2017
44	Visual complaints in intracranial germinomas. ⁶¹	Frappaz D...Carrie C	28436607	2017
45	Radiotherapy and chemotherapy plus radiation in the treatment of patients with pure intracranial germinoma: A meta-analysis. ⁶¹	Fu H...Xing B	28602629	2017
46	Intracranial Germinoma: Systemic Chemotherapy in Addition to Dose-Reduced Radiation Therapy. ⁶¹	Chiec L...Karim NA	28614087	2017
47	Pediatric intracranial germinoma: use chemotherapy first. ⁶¹	Lee A...Lee KS	29044451	2017
48	Adipsic diabetes insipidus revealing a bifocal intracranial germinoma. ⁶¹	Kreutz J...Beckers A	28483362	2017
49	Anomalous intracranial germinoma with unilateral cerebral peduncle swelling. ⁶¹	Chua FHZ...Low SYY	28283777	2017
50	Craniospinal irradiation using helical tomotherapy for central nervous system tumors. ⁶¹	Schiopu SR...Sterzing F	28096196	2017

Sources

Genes for Central Nervous System Germinoma

Genes related to Central Nervous System Germinoma (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	JMJD1C	Jumonji Domain Containing 1C	Protein Coding	25	Susceptibility factor ⁵⁸	24896186
2	POU5F1	POU Class 5 Homeobox 1	Protein Coding	11.53	DISEASES inferred ¹⁵ GeneCards inferred via : Publications (show sections)
3	ALPP	Alkaline Phosphatase, Placental	Protein Coding	7.11	GeneCards inferred via : Publications (show sections)
4	MIR302A	MicroRNA 302a	RNA Gene	5.61	DISEASES inferred ¹⁵
5	MIR302C	MicroRNA 302c	RNA Gene	5.37	DISEASES inferred ¹⁵
6	RTRAF	RNA Transcription, Translation And Transport Factor	Protein Coding	5.19	DISEASES inferred ¹⁵
7	CT45A1	Cancer/Testis Antigen Family 45 Member A1	Protein Coding	5	DISEASES inferred ¹⁵

Sources

Variations for Central Nervous System Germinoma

Sources

Expression for Central Nervous System Germinoma

Search GEO for disease gene expression data for Central Nervous System Germinoma.

Sources

Pathways for Central Nervous System Germinoma

Pathways related to Central Nervous System Germinoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers ⁶⁴	11.28	POU5F1 ALPP
2	Preimplantation Embryo ¹	10.73	POU5F1 MIR302A
3	Cell Differentiation - Index ¹	10.2	MIR302C MIR302A

Sources

GO Terms for Central Nervous System Germinoma

Sources

Sources for Central Nervous System Germinoma

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ EFO

¹⁸ ExPASy

¹⁹ FMA

²⁰ GARD

²¹ GeneAnalytics

²² GeneCards

²³ GeneGo (Thomson Reuters)

²⁴ GeneHancer via GeneCards

²⁵ GeneReviews

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HMDB

³¹ HPO

³² ICD10

³³ ICD10 via Orphanet

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ KEGG

³⁷ LifeMap

³⁸ LncRNADisease

³⁹ LOVD

⁴⁰ MalaCards

⁴¹ MedGen

⁴² MedlinePlus

⁴³ MedlinePlus Genetics

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NINDS

⁵⁴ Novoseek

⁵⁵ Novus Biologicals

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 20-May-2021)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubMed

⁶² PubMed Health

⁶³ QIAGEN

⁶⁴ R&D Systems

⁶⁵ Reactome

⁶⁶ Sino Biological

⁶⁷ SNOMED-CT

⁶⁸ SNOMED-CT via HPO

⁶⁹ Tocris

⁷⁰ UMLS

⁷¹ UMLS via Orphanet

⁷² UniProtKB/Swiss-Prot

⁷³ Wikipedia