MCID: CNT037
MIFTS: 36

Central Nervous System Germinoma

Categories: Rare diseases, Neuronal diseases, Endocrine diseases, Cancer diseases

Aliases & Classifications for Central Nervous System Germinoma

MalaCards integrated aliases for Central Nervous System Germinoma:

Name: Central Nervous System Germinoma 12 53 15 73
Germinoma of the Central Nervous System 53 59
Intracranial Germinoma 53 73
Germinoma of Cns 12

Characteristics:

Orphanet epidemiological data:

59
germinoma of the central nervous system
Inheritance: Not applicable; Age of onset: Adolescent,Adult,Childhood;

Classifications:



External Ids:

Disease Ontology 12 DOID:4438
NCIt 50 C7009
Orphanet 59 ORPHA91352
UMLS via Orphanet 74 C1333813

Summaries for Central Nervous System Germinoma

MalaCards based summary : Central Nervous System Germinoma, also known as germinoma of the central nervous system, is related to brain germinoma and seminoma. An important gene associated with Central Nervous System Germinoma is JMJD1C (Jumonji Domain Containing 1C), and among its related pathways/superpathways are Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways and G alpha (s) signalling events. The drugs Etoposide and Carboplatin have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and t cells.

Related Diseases for Central Nervous System Germinoma

Diseases in the Central Nervous System Germinoma family:

Adult Central Nervous System Germinoma

Diseases related to Central Nervous System Germinoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 46)
# Related Disease Score Top Affiliating Genes
1 brain germinoma 31.6 AVP POU5F1
2 seminoma 29.6 ALPP POU5F1
3 diabetes insipidus 29.1 AVP POMC
4 childhood central nervous system germinoma 12.3
5 adult central nervous system germinoma 12.3
6 malignant leydig cell tumor 10.1 POMC POU5F1
7 mediastinitis 10.0
8 multiple sclerosis 9.9
9 endodermal sinus tumor 9.9
10 embryonal carcinoma 9.9
11 peritonitis 9.9
12 medulloblastoma 9.9
13 meningitis 9.9
14 lennox-gastaut syndrome 9.8 ALPP POMC
15 epidermoid cysts 9.7
16 smith-lemli-opitz syndrome 9.7
17 opitz gbbb syndrome, type i 9.7
18 hypogonadotropic hypogonadism 9.7
19 cauda equina syndrome 9.7
20 cornelia de lange syndrome 9.7
21 teratoma 9.7
22 cerebritis 9.7
23 choriocarcinoma 9.7
24 polyradiculopathy 9.7
25 embryonal testis carcinoma 9.7
26 neuronitis 9.7
27 hypopituitarism 9.7
28 lymphocytic hypophysitis 9.7
29 testicular seminoma 9.7
30 tremor 9.7
31 growing teratoma syndrome 9.7
32 tuberculous epididymitis 9.7 AVP POMC
33 inappropriate adh syndrome 9.7 AVP POMC
34 secondary hypertrophic osteoarthropathy 9.7 AVP POMC
35 syndrome of inappropriate antidiuretic hormone 9.7 AVP POMC
36 central nervous system organ benign neoplasm 9.7 AVP POMC
37 cervix small cell carcinoma 9.7 AVP POMC
38 diabetes insipidus, neurohypophyseal 9.6 AVP POMC
39 premenstrual tension 9.6 AVP POMC
40 chromophobe adenoma 9.6 AVP POMC
41 pancreas disease 9.6 AVP POMC
42 pituitary hormone deficiency, combined, 2 9.6 AVP POMC
43 pituitary gland disease 9.5 AVP POMC
44 urinary system disease 9.2 AVP POMC
45 central nervous system germ cell tumor 9.2 AVP POMC POU5F1
46 small cell cancer of the lung 9.0 AVP POMC

Graphical network of the top 20 diseases related to Central Nervous System Germinoma:



Diseases related to Central Nervous System Germinoma

Symptoms & Phenotypes for Central Nervous System Germinoma

Drugs & Therapeutics for Central Nervous System Germinoma

Drugs for Central Nervous System Germinoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 90)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Etoposide Approved Phase 3,Phase 2,Phase 1 33419-42-0 36462
2
Carboplatin Approved Phase 3,Phase 2,Phase 1 41575-94-4 10339178 498142 38904
3
Cyclophosphamide Approved, Investigational Phase 3,Phase 2,Phase 1 50-18-0, 6055-19-2 2907
4
Lenograstim Approved, Investigational Phase 3,Phase 2,Phase 1 135968-09-1
5
Cisplatin Approved Phase 3,Phase 2,Phase 1 15663-27-1 84093 441203 2767
6
Dexamethasone Approved, Investigational, Vet_approved Phase 3,Phase 1 50-02-2 5743
7
Granisetron Approved, Investigational Phase 3 109889-09-0 3510
8
Ondansetron Approved Phase 3 99614-02-5 4595
9 Alkylating Agents Phase 3,Phase 2,Phase 1
10 Topoisomerase Inhibitors Phase 3,Phase 2,Phase 1
11 Etoposide phosphate Phase 3,Phase 2,Phase 1
12 Immunosuppressive Agents Phase 3,Phase 2,Phase 1
13 Antirheumatic Agents Phase 3,Phase 2,Phase 1
14 Antineoplastic Agents, Alkylating Phase 3,Phase 2,Phase 1
15 Antineoplastic Agents, Phytogenic Phase 3,Phase 2,Phase 1
16 Dexamethasone acetate Phase 3,Phase 1 1177-87-3
17 Adjuvants, Immunologic Phase 3,Phase 1
18 Gastrointestinal Agents Phase 3,Phase 1
19 Emetics Phase 3
20 Peripheral Nervous System Agents Phase 3,Phase 1
21 Antiemetics Phase 3,Phase 1
22 BB 1101 Phase 3,Phase 1
23 Autonomic Agents Phase 3,Phase 1
24
Bleomycin Approved, Investigational Phase 2 11056-06-7 5360373
25
Mechlorethamine Approved, Investigational Phase 2,Phase 1 51-75-2 4033
26
Ifosfamide Approved Phase 2,Phase 1 3778-73-2 3690
27
Thiotepa Approved, Investigational Phase 2,Phase 1 52-24-4 5453
28
Dasatinib Approved, Investigational Phase 1, Phase 2 302962-49-8 3062316
29 Anti-Bacterial Agents Phase 2,Phase 1
30 Antibiotics, Antitubercular Phase 2
31
Isophosphamide mustard Phase 2,Phase 1 0
32 Liver Extracts Phase 1, Phase 2
33 Protein Kinase Inhibitors Phase 1, Phase 2
34
Dacarbazine Approved, Investigational Phase 1 4342-03-4 5351166
35
Vincristine Approved, Investigational Phase 1 2068-78-2, 57-22-7 5978
36
Temozolomide Approved, Investigational Phase 1 85622-93-1 5394
37
Sunitinib Approved, Investigational Phase 1 341031-54-7, 557795-19-4 5329102
38
Oxaliplatin Approved, Investigational Phase 1 61825-94-3 5310940 9887054 43805 6857599
39
Bortezomib Approved, Investigational Phase 1 179324-69-7 387447 93860
40
Vorinostat Approved, Investigational Phase 1 149647-78-9 5311
41
Fluorouracil Approved Phase 1 51-21-8 3385
42
Levoleucovorin Approved, Investigational Phase 1 68538-85-2
43
Mannitol Approved, Investigational Phase 1 69-65-8 453 6251
44
Acetylcysteine Approved, Investigational Phase 1 616-91-1 12035
45
leucovorin Approved, Nutraceutical Phase 1 58-05-9 143 6006
46
Folic Acid Approved, Nutraceutical, Vet_approved Phase 1 59-30-3 6037
47
Vitamin A Approved, Nutraceutical, Vet_approved Phase 1 11103-57-4, 68-26-8 445354
48 Analgesics Phase 1
49 6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo(2,1-b)thiazole Phase 1
50 Micronutrients Phase 1

Interventional clinical trials:

(show all 19)
# Name Status NCT ID Phase Drugs
1 Radiation Therapy Compared With Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Primary Central Nervous System (CNS) Germ Cell Tumor Completed NCT00085098 Phase 3 carboplatin;cisplatin;cyclophosphamide;etoposide
2 Acupressure in Controlling Nausea in Young Patients Receiving Highly Emetogenic Chemotherapy Completed NCT01346267 Phase 3
3 Chemotherapy Plus Reduced Radiotherapy in Intracranial Germinoma Unknown status NCT02782754 Phase 2 Carboplatin;Etoposide;Cyclophosphamide;Bleomycin
4 Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors Completed NCT00047320 Phase 2 carboplatin;etoposide;ifosfamide;thiotepa
5 Cisplatin and Etoposide Prior to Radiation Therapy in Treating Patients With CNS Tumors Completed NCT00002472 Phase 2 cisplatin;etoposide
6 Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors Active, not recruiting NCT00788125 Phase 1, Phase 2 carboplatin;dasatinib;etoposide phosphate;ifosfamide
7 Chemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors Suspended NCT01602666 Phase 2 Carboplatin;Etoposide;Ifosfamide
8 Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors Completed NCT01076530 Phase 1 vorinostat;temozolomide
9 Vorinostat and Bortezomib in Treating Young Patients With Refractory or Recurrent Solid Tumors, Including Central Nervous System Tumors and Lymphoma Completed NCT00994500 Phase 1 vorinostat;bortezomib
10 Pazopanib Hydrochloride in Treating Young Patients With Solid Tumors That Have Relapsed or Not Responded to Treatment Completed NCT00929903 Phase 1 pazopanib hydrochloride
11 Combination Chemotherapy in Treating Young Patients With Advanced Solid Tumors Completed NCT00281944 Phase 1 oxaliplatin;fluorouracil;leucovorin calcium
12 Sunitinib in Treating Young Patients With Refractory Solid Tumors Completed NCT00387920 Phase 1 sunitinib malate
13 Imetelstat Sodium in Treating Young Patients With Refractory or Recurrent Solid Tumors or Lymphoma Completed NCT01273090 Phase 1 imetelstat sodium
14 PTC299 in Treating Young Patients With Refractory or Recurrent Primary Central Nervous System Tumors Completed NCT01158300 Phase 1 VEGF inhibitor PTC299
15 Chemotherapy Plus Peripheral Stem Cell Transplantation in Treating Infants With Malignant Brain or Spinal Cord Tumors Completed NCT00003141 Phase 1 carboplatin;cisplatin;cyclophosphamide;etoposide;thiotepa;vincristine sulfate
16 Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia Terminated NCT01088763 Phase 1 gamma-secretase/Notch signalling pathway inhibitor RO4929097;dexamethasone
17 Acetylcysteine, Mannitol, Combination Chemotherapy, and Sodium Thiosulfate in Treating Children With Malignant Brain Tumors Terminated NCT00238173 Phase 1 acetylcysteine;carboplatin;cyclophosphamide;etoposide phosphate;mannitol;sodium thiosulfate
18 Collecting and Storing Tissue From Young Patients With Cancer Recruiting NCT00898755
19 Studying Cerebrospinal Fluid Proteins and Angiogenesis Proteins in Young Patients With Newly Diagnosed Central Nervous System Tumors Withdrawn NCT00897858

Search NIH Clinical Center for Central Nervous System Germinoma

Genetic Tests for Central Nervous System Germinoma

Anatomical Context for Central Nervous System Germinoma

MalaCards organs/tissues related to Central Nervous System Germinoma:

41
Brain, Spinal Cord, T Cells, Liver, Bone

Publications for Central Nervous System Germinoma

Articles related to Central Nervous System Germinoma:

(show all 16)
# Title Authors Year
1
Outcomes of children with central nervous system germinoma treated with multi-agent chemotherapy followed by reduced radiation. ( 26744133 )
2016
2
Improvement of Long-term Results with Neoadjuvant Chemotherapy andA Radiotherapy for Central Nervous System Germinoma. ( 26115804 )
2015
3
Feasibility of dasatinib in children and adolescents with new or recurrent central nervous system germinoma. ( 23754592 )
2013
4
An unusual case of primary central nervous system germinoma with meningeal dissemination. ( 22936081 )
2012
5
Neurocognitive outcomes in pediatric and adolescent patients with central nervous system germinoma treated with a strategy of chemotherapy followed by reduced-dose and volume irradiation. ( 21495164 )
2011
6
Outcome of central nervous system germinoma treatment by chemoradiation. ( 21516012 )
2011
7
Long-term follow-up of dose-adapted and reduced-field radiotherapy with or without chemotherapy for central nervous system germinoma. ( 20045266 )
2010
8
Regression of primary central nervous system germinoma after dexamethasone administration: a case report. ( 20367268 )
2010
9
Management of central nervous system germinoma: proposal for a modern strategy. ( 19329866 )
2009
10
Diffusion-weighted imaging characteristics of primary central nervous system germinoma with histopathologic correlation: a retrospective study. ( 19643635 )
2009
11
Outcome of patients with recurrent medulloblastoma or central nervous system germinoma treated with low dose continuous intravenous etoposide along with dose-intensive chemotherapy followed by autologous hematopoietic stem cell rescue. ( 19326417 )
2009
12
OCT4 immunohistochemistry is superior to placental alkaline phosphatase (PLAP) in the diagnosis of central nervous system germinoma. ( 15725806 )
2005
13
Patterns of failure after induction chemotherapy followed by consolidative radiation therapy for children with central nervous system germinoma. ( 14595717 )
2003
14
Induction chemotherapy followed by reduced-volume radiation therapy for newly diagnosed central nervous system germinoma. ( 9420074 )
1998
15
Radiation therapy for histologically confirmed primary central nervous system germinoma. ( 9276355 )
1997
16
Hormonal and metabolic abnormalities associated with central nervous system germinoma in children and adolescents and the effect of therapy: report of 10 patients. ( 6256407 )
1981

Variations for Central Nervous System Germinoma

Expression for Central Nervous System Germinoma

Search GEO for disease gene expression data for Central Nervous System Germinoma.

Pathways for Central Nervous System Germinoma

Pathways related to Central Nervous System Germinoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.37 AVP POU5F1
2 11.12 AVP POMC
3 10.75 ALPP POU5F1

GO Terms for Central Nervous System Germinoma

Cellular components related to Central Nervous System Germinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule GO:0030141 8.62 AVP POMC

Biological processes related to Central Nervous System Germinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 generation of precursor metabolites and energy GO:0006091 8.62 AVP POMC

Molecular functions related to Central Nervous System Germinoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.16 AVP POMC
2 transcription regulatory region sequence-specific DNA binding GO:0000976 8.96 JMJD1C POU5F1
3 neuropeptide hormone activity GO:0005184 8.62 AVP POMC

Sources for Central Nervous System Germinoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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