MCID: CNT023
MIFTS: 25

Central Nervous System Hemangioma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Hemangioma

MalaCards integrated aliases for Central Nervous System Hemangioma:

Name: Central Nervous System Hemangioma 12 15
Hemangioma of the Central Nervous System 73
Hemangioma of Cns 12

Classifications:



External Ids:

Disease Ontology 12 DOID:501
NCIt 50 C7004
UMLS 73 C1333957

Summaries for Central Nervous System Hemangioma

MalaCards based summary : Central Nervous System Hemangioma, also known as hemangioma of the central nervous system, is related to intracranial structure hemangioma and human venous malformation. An important gene associated with Central Nervous System Hemangioma is KRIT1 (KRIT1, Ankyrin Repeat Containing), and among its related pathways/superpathways are MAPK-Erk Pathway and B Cell Receptor Signaling Pathway (sino). Affiliated tissues include skin, and related phenotype is cardiovascular system.

Related Diseases for Central Nervous System Hemangioma

Graphical network of the top 20 diseases related to Central Nervous System Hemangioma:



Diseases related to Central Nervous System Hemangioma

Symptoms & Phenotypes for Central Nervous System Hemangioma

MGI Mouse Phenotypes related to Central Nervous System Hemangioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.17 CCM2 KRIT1 MAP3K3 PDCD10 RAP1A RAP1B

Drugs & Therapeutics for Central Nervous System Hemangioma

Search Clinical Trials , NIH Clinical Center for Central Nervous System Hemangioma

Genetic Tests for Central Nervous System Hemangioma

Anatomical Context for Central Nervous System Hemangioma

MalaCards organs/tissues related to Central Nervous System Hemangioma:

41
Skin

Publications for Central Nervous System Hemangioma

Articles related to Central Nervous System Hemangioma:

# Title Authors Year
1
Capillary hemangioma of the central nervous system: a comparative study with lobular capillary hemangioma of the skin. ( 15365728 )
2005
2
Capillary hemangioma of the central nervous system. ( 15255254 )
2004

Variations for Central Nervous System Hemangioma

Expression for Central Nervous System Hemangioma

Search GEO for disease gene expression data for Central Nervous System Hemangioma.

Pathways for Central Nervous System Hemangioma

Pathways related to Central Nervous System Hemangioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.28 ITGB1BP1 MAP3K3 RAP1A RAP1B
2
Show member pathways
11.87 MAP3K3 RAP1A RAP1B
3
Show member pathways
11.31 MAP3K3 RAP1A RAP1B
4 11.1 KRIT1 RAP1A
5 10.78 CCM2 MAP3K3
6 10.59 CCM2 MAP3K3
7 9.83 RAP1A RAP1B

GO Terms for Central Nervous System Hemangioma

Cellular components related to Central Nervous System Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.36 CCM2 ITGB1BP1 KRIT1 MAP3K3 MOB4 PDCD10

Biological processes related to Central Nervous System Hemangioma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 cellular response to cAMP GO:0071320 9.54 RAP1A RAP1B
2 small GTPase mediated signal transduction GO:0007264 9.54 KRIT1 RAP1A RAP1B
3 activation of MAPKK activity GO:0000186 9.52 MAP3K3 RAP1A
4 positive regulation of Notch signaling pathway GO:0045747 9.51 ITGB1BP1 PDCD10
5 negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 9.49 ITGB1BP1 PDCD10
6 positive regulation of intracellular protein transport GO:0090316 9.48 PDCD10 RIPOR1
7 regulation of establishment of cell polarity GO:2000114 9.46 KRIT1 RAP1B
8 microvillus assembly GO:0030033 9.43 RAP1A RAP1B
9 establishment of endothelial barrier GO:0061028 9.4 RAP1A RAP1B
10 response to carbohydrate GO:0009743 9.32 RAP1A RAP1B
11 Rap protein signal transduction GO:0032486 9.26 RAP1A RAP1B
12 establishment of Golgi localization GO:0051683 9.16 PDCD10 RIPOR1
13 negative regulation of synaptic vesicle exocytosis GO:2000301 8.96 RAP1A RAP1B
14 regulation of cell junction assembly GO:1901888 8.62 RAP1A RAP1B

Molecular functions related to Central Nervous System Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein-containing complex binding GO:0044877 9.02 ITGB1BP1 KRIT1 RAP1A RAP1B STRN

Sources for Central Nervous System Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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