MCID: CNT023
MIFTS: 26

Central Nervous System Hemangioma

Categories: Cancer diseases, Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Hemangioma

MalaCards integrated aliases for Central Nervous System Hemangioma:

Name: Central Nervous System Hemangioma 12 15
Hemangioma of the Central Nervous System 71
Hemangioma of Cns 12

Classifications:



External Ids:

Disease Ontology 12 DOID:501
NCIt 49 C7004
UMLS 71 C1333957

Summaries for Central Nervous System Hemangioma

MalaCards based summary : Central Nervous System Hemangioma, also known as hemangioma of the central nervous system, is related to cerebral cavernous malformations and epidural neoplasm. An important gene associated with Central Nervous System Hemangioma is RPL34 (Ribosomal Protein L34), and among its related pathways/superpathways is Aryl Hydrocarbon Receptor. The drugs Atorvastatin and Hypolipidemic Agents have been mentioned in the context of this disorder. Affiliated tissues include skin, heart and breast.

Related Diseases for Central Nervous System Hemangioma

Diseases related to Central Nervous System Hemangioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 130)
# Related Disease Score Top Affiliating Genes
1 cerebral cavernous malformations 11.5
2 epidural neoplasm 10.1 RPL34 CD34
3 mechanical ectropion 10.0 NF1 CD34
4 epithelioid neurofibroma 10.0 NF1 CD34
5 neurofibroma 10.0 NF1 CD34
6 pacinian tumor 10.0 NF1 CD34
7 plexiform schwannoma 10.0 NF1 CD34
8 skin lipoma 10.0 RET NF1
9 small intestine leiomyoma 10.0 NF1 CD34
10 meningocele 10.0 RPL34 NF1
11 atypical neurofibroma 10.0 NF1 CD34
12 orbital cancer 10.0 NF1 CD34
13 epithelioid malignant peripheral nerve sheath tumor 10.0 NF1 CD34
14 malignant peripheral nerve sheath tumor 10.0 NF1 CD34
15 cellular schwannoma 10.0 NF1 CD34
16 bladder leiomyoma 10.0 NF1 CD34
17 extra-adrenal pheochromocytoma 10.0 RET NF1
18 gliofibroma 10.0 NF1 CD34
19 adult malignant schwannoma 10.0 NF1 CD34
20 sporadic pheochromocytoma 10.0 RET NF1
21 esophagus leiomyoma 10.0 RET NF1
22 malignant spindle cell melanoma 10.0 NF1 CD34
23 adrenal medulla cancer 10.0 RET NF1
24 neurofibrosarcoma 10.0 NF1 CD34
25 persistent generalized lymphadenopathy 10.0 RET NF1
26 multiple endocrine neoplasia, type i 9.9 RET NF1
27 multiple endocrine neoplasia, type iib 9.9 RET NF1
28 plexiform neurofibroma 9.9 NF1 CD34
29 intestinal obstruction 9.9 RET CD34
30 bone structure disease 9.9 RPL34 NF1
31 exophthalmos 9.9 NF1 CD34
32 central nervous system benign neoplasm 9.9 NF1 CD34
33 lipomatosis, multiple 9.9 NF1 CD34
34 multiple endocrine neoplasia, type iia 9.9 RET NF1
35 carney complex variant 9.9 RET NF1
36 lymph node disease 9.9 RET NF1
37 skin benign neoplasm 9.9 NF1 CD34
38 vascular cancer 9.9 PECAM1 CD34
39 skin epithelioid hemangioma 9.9 PECAM1 CD34
40 prostate angiosarcoma 9.9 PECAM1 CD34
41 angiosarcoma 9.9 PECAM1 CD34
42 central nervous system angiosarcoma 9.9 PECAM1 CD34
43 intravascular angioleiomyoma 9.9 PECAM1 CD34
44 heart fibrosarcoma 9.9 PECAM1 CD34
45 fibroma 9.9 PECAM1 CD34
46 ovarian angiosarcoma 9.9 PECAM1 CD34
47 neurofibromatosis, type iv, of riccardi 9.9 RET NF1
48 conventional angiosarcoma 9.9 PECAM1 CD34
49 angiomyoma 9.9 PECAM1 CD34
50 aortic malignant tumor 9.9 PECAM1 CD34

Graphical network of the top 20 diseases related to Central Nervous System Hemangioma:



Diseases related to Central Nervous System Hemangioma

Symptoms & Phenotypes for Central Nervous System Hemangioma

Drugs & Therapeutics for Central Nervous System Hemangioma

Drugs for Central Nervous System Hemangioma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Atorvastatin Approved Phase 1, Phase 2 134523-00-5 60823
2 Hypolipidemic Agents Phase 1, Phase 2
3 Anticholesteremic Agents Phase 1, Phase 2
4 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 1, Phase 2
5 Antimetabolites Phase 1, Phase 2
6 Lipid Regulating Agents Phase 1, Phase 2
7
Simvastatin Approved Early Phase 1 79902-63-9 54454

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase I-II Randomized, Placebo-Controlled, Single-Blinded, Single-Site Clinical Trial of Atorvastatin in the Treatment of Cavernous Angiomas With Symptomatic Hemorrhage Exploratory Proof of Concept (AT CASH EPOC) Recruiting NCT02603328 Phase 1, Phase 2 Atorvastatin
2 Permeability MRI in Cerebral Cavernous Malformations Type 1 in New Mexico: Effects of Statins Completed NCT01764451 Early Phase 1 Simvastatin
3 CASH (Cavernous Angiomas With Symptomatic Hemorrhage) Trial Readiness Recruiting NCT03652181
4 Quantitative Susceptibility Mapping Biomarker, Brain Structure and Connectome Associated With Cerebral Cavernous Malformation Related Epilepsy and Outcome After Surgery Recruiting NCT04076449
5 Modifiers of Disease Severity and Progression in Cerebral Cavernous Malformations Recruiting NCT01764529

Search NIH Clinical Center for Central Nervous System Hemangioma

Genetic Tests for Central Nervous System Hemangioma

Anatomical Context for Central Nervous System Hemangioma

MalaCards organs/tissues related to Central Nervous System Hemangioma:

40
Skin, Heart, Breast, Lung, Bone, Spleen, Brain

Publications for Central Nervous System Hemangioma

Articles related to Central Nervous System Hemangioma:

# Title Authors PMID Year
1
An unusual case of cavernous hemangioma of the rib in a young man with lung tuberculosis: a brief review and case report. 61
23728568 2013
2
Organ donor found to have von Hippel-Lindau disease: case report. 61
21693214 2011
3
Capillary hemangioma of the central nervous system: a comparative study with lobular capillary hemangioma of the skin. 61
15365728 2005
4
Capillary hemangioma of the central nervous system. 61
15255254 2004
5
von Hippel-Lindau disease. 61
11578646 2001
6
[Cavernous hemangioma of the central nervous system (author's transl)]. 61
83550 1978

Variations for Central Nervous System Hemangioma

Expression for Central Nervous System Hemangioma

Search GEO for disease gene expression data for Central Nervous System Hemangioma.

Pathways for Central Nervous System Hemangioma

Pathways related to Central Nervous System Hemangioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.3 RET NF1

GO Terms for Central Nervous System Hemangioma

Cellular components related to Central Nervous System Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell periphery GO:0071944 8.62 PECAM1 CD34

Biological processes related to Central Nervous System Hemangioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signal transduction GO:0007165 9.62 RET PECAM1 NF1 CD34
2 cell adhesion GO:0007155 9.33 RET PECAM1 CD34
3 wound healing GO:0042060 9.26 PECAM1 NF1
4 positive regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001241 8.96 RET NF1
5 glomerular endothelium development GO:0072011 8.62 PECAM1 CD34

Sources for Central Nervous System Hemangioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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