MCID: CNT010
MIFTS: 31

Central Nervous System Hematologic Cancer

Categories: Blood diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Hematologic Cancer

MalaCards integrated aliases for Central Nervous System Hematologic Cancer:

Name: Central Nervous System Hematologic Cancer 12 15
Hematopoietic Neoplasm of Central Nervous System 12
Central Nervous System Hematopoietic Neoplasm 74
Cns Hematopoietic Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5772
NCIt 51 C5503
UMLS 74 C1332882

Summaries for Central Nervous System Hematologic Cancer

Disease Ontology : 12 A hematologic cancer and central nervous system neoplasm that is located in the central nervous system.

MalaCards based summary : Central Nervous System Hematologic Cancer, also known as hematopoietic neoplasm of central nervous system, is related to heart lymphoma and intravascular large b-cell lymphoma. An important gene associated with Central Nervous System Hematologic Cancer is BCL6 (BCL6 Transcription Repressor), and among its related pathways/superpathways are Innate Immune System and Immune response NFAT in immune response. Affiliated tissues include b cells, t cells and colon, and related phenotypes are hematopoietic system and homeostasis/metabolism

Related Diseases for Central Nervous System Hematologic Cancer

Diseases related to Central Nervous System Hematologic Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 heart lymphoma 10.3 BCL6 MME
2 intravascular large b-cell lymphoma 10.3 BCL6 MME
3 t-cell/histiocyte rich large b cell lymphoma 10.3 BCL6 MME
4 primary central nervous system lymphoma 10.3 BCL6 MYD88
5 primary mediastinal large b-cell lymphoma 10.3 BCL6 IRF4
6 primary cutaneous diffuse large b-cell lymphoma, leg type 10.3 IRF4 MYD88
7 colon lymphoma 10.3 BCL6 IRF4
8 intraocular lymphoma 10.3 BCL6 IL10
9 primary effusion lymphoma 10.3 BCL6 IRF4
10 multicentric castleman disease 10.2 BCL6 IL10
11 trichuriasis 10.2 IL10 MME
12 castleman disease 10.2 BCL6 IL10
13 relapsed/refractory diffuse large b-cell lymphoma 10.2 GBA IRF4
14 bladder lymphoma 10.2 GBA MME
15 ovarian lymphoma 10.2 GBA MME
16 testicular lymphoma 10.2 BCL6 MME MYD88
17 lymphatic system cancer 10.2 BCL6 MME
18 follicular lymphoma 10.1 BCL6 IRF4 MME
19 agammaglobulinemia, non-bruton type 10.1 BTK CD79B
20 central nervous system lymphoma 10.1 BCL6 IL10 MYD88
21 gaucher disease, type ii 10.1 GBA IL10
22 angioimmunoblastic t-cell lymphoma 10.1 BCL6 MME
23 waldenstroem's macroglobulinemia 10.1 BTK MYD88
24 hand, foot and mouth disease 10.1 GBA IL10
25 irak4 deficiency 10.0 BTK MYD88
26 myd88 deficiency 10.0 BTK MYD88
27 ecthyma 10.0 BTK CD79B
28 marginal zone b-cell lymphoma 10.0 BCL6 IRF4 MME MYD88
29 mantle cell lymphoma 10.0 BCL6 BTK MME
30 poliomyelitis 10.0 BTK IL10
31 leukocyte disease 9.9 BCL6 GBA IRF4 MME
32 lymphoma, non-hodgkin, familial 9.9 BCL6 GBA IRF4 MME
33 lymphocytic leukemia 9.9 BTK MME MYD88
34 complex regional pain syndrome 9.9 IL10 MME
35 lymphoma, mucosa-associated lymphoid type 9.9 BCL6 CARD11 IRF4 MME
36 plasma protein metabolism disease 9.8 BTK CD79B MME MYD88
37 transient hypogammaglobulinemia of infancy 9.8 BTK IL10
38 diffuse large b-cell lymphoma 9.5 BCL6 CARD11 CD79B IRF4 MME MYD88
39 b-cell lymphomas 9.5 BCL6 BTK CARD11 IRF4 MME

Graphical network of the top 20 diseases related to Central Nervous System Hematologic Cancer:



Diseases related to Central Nervous System Hematologic Cancer

Symptoms & Phenotypes for Central Nervous System Hematologic Cancer

MGI Mouse Phenotypes related to Central Nervous System Hematologic Cancer:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.97 BCL6 BTK CARD11 CD79B GBA IL10
2 homeostasis/metabolism MP:0005376 9.96 BCL6 BTK CARD11 GBA IL10 IRF4
3 immune system MP:0005387 9.85 BCL6 BTK CARD11 CD79B GBA IL10
4 liver/biliary system MP:0005370 9.43 BCL6 GBA IL10 MME PASK TBL1XR1
5 respiratory system MP:0005388 9.1 BCL6 CARD11 GBA IL10 MYD88 PASK

Drugs & Therapeutics for Central Nervous System Hematologic Cancer

Search Clinical Trials , NIH Clinical Center for Central Nervous System Hematologic Cancer

Genetic Tests for Central Nervous System Hematologic Cancer

Anatomical Context for Central Nervous System Hematologic Cancer

MalaCards organs/tissues related to Central Nervous System Hematologic Cancer:

42
B Cells, T Cells, Colon, Heart

The Foundational Model of Anatomy Ontology organs/tissues related to Central Nervous System Hematologic Cancer:

20
The Central Nervous System

Publications for Central Nervous System Hematologic Cancer

Variations for Central Nervous System Hematologic Cancer

Expression for Central Nervous System Hematologic Cancer

Search GEO for disease gene expression data for Central Nervous System Hematologic Cancer.

Pathways for Central Nervous System Hematologic Cancer

GO Terms for Central Nervous System Hematologic Cancer

Biological processes related to Central Nervous System Hematologic Cancer according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.83 BCL6 BTK CD79B MYD88
2 regulation of gene expression GO:0010468 9.69 IL10 MYD88 TBL1XR1
3 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.61 BTK CARD11 MYD88
4 B cell proliferation GO:0042100 9.49 CARD11 IL10
5 MyD88-dependent toll-like receptor signaling pathway GO:0002755 9.48 BTK MYD88
6 negative regulation of interleukin-6 production GO:0032715 9.46 GBA IL10
7 cytokine-mediated signaling pathway GO:0019221 9.46 BCL6 IL10 IRF4 MYD88
8 defense response to protozoan GO:0042832 9.4 IL10 IRF4
9 negative regulation of B cell proliferation GO:0030889 9.37 BTK IL10
10 negative regulation of growth of symbiont in host GO:0044130 9.32 IL10 MYD88
11 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.26 CARD11 IRF4
12 type 2 immune response GO:0042092 8.96 BCL6 IL10
13 B cell differentiation GO:0030183 8.92 BCL6 CARD11 CD79B IL10

Molecular functions related to Central Nervous System Hematologic Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 9.4 BCL6 BTK CARD11 CD79B GBA IL10

Sources for Central Nervous System Hematologic Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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