MCID: CNT010
MIFTS: 28

Central Nervous System Hematologic Cancer

Categories: Blood diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Hematologic Cancer

MalaCards integrated aliases for Central Nervous System Hematologic Cancer:

Name: Central Nervous System Hematologic Cancer 12 15
Hematopoietic Neoplasm of Central Nervous System 12
Central Nervous System Hematopoietic Neoplasm 71
Cns Hematopoietic Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:5772
NCIt 49 C5503
UMLS 71 C1332882

Summaries for Central Nervous System Hematologic Cancer

Disease Ontology : 12 A hematologic cancer and central nervous system neoplasm that is located in the central nervous system.

MalaCards based summary : Central Nervous System Hematologic Cancer, also known as hematopoietic neoplasm of central nervous system, is related to idiopathic cd4-positive t-lymphocytopenia and ureteral lymphoma. An important gene associated with Central Nervous System Hematologic Cancer is IRF4 (Interferon Regulatory Factor 4), and among its related pathways/superpathways are NF-kappaB Signaling and B cell receptor signaling pathway (KEGG). Affiliated tissues include central nervous system, b cells and t cells, and related phenotypes are hematopoietic system and immune system

Related Diseases for Central Nervous System Hematologic Cancer

Diseases related to Central Nervous System Hematologic Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 168)
# Related Disease Score Top Affiliating Genes
1 idiopathic cd4-positive t-lymphocytopenia 10.6 CD4 BCL6
2 ureteral lymphoma 10.6 MME BCL6
3 primary mediastinal large b-cell lymphoma 10.6 IRF4 BCL6
4 heart lymphoma 10.6 MME BCL6
5 ovarian lymphoma 10.6 MME BCL6
6 selective igg deficiency disease 10.6 IRF4 CD79A
7 hilar lung carcinoma 10.6 MME CD79A
8 lung hilum cancer 10.6 MME CD79A
9 small intestine lymphoma 10.5 CD79A BCL6
10 american histoplasmosis 10.5 TNFRSF8 CD4
11 nodular lymphocyte predominant hodgkin lymphoma 10.5 TNFRSF8 BCL6
12 bird fancier's lung 10.5 CD79A CD4
13 hodgkin's lymphoma, lymphocytic-histiocytic predominance 10.5 TNFRSF8 BCL6
14 gamma heavy chain disease 10.5 MYD88 IGHV4-38-2
15 chronic graft versus host disease 10.5 CD79A CD4
16 syphilitic meningitis 10.5 CXCL13 CD4
17 heavy chain disease 10.5 MYD88 CD79A
18 high grade b-cell lymphoma with myc and/ or bcl2 and/or bcl6 rearrangement 10.5 MYC BCL6
19 retina lymphoma 10.5 IGHV4-38-2 CXCL13
20 lymphoma aids related 10.5 MYC BCL6
21 b cell deficiency 10.4 IRF4 IGHV4-38-2 CD4
22 asymptomatic neurosyphilis 10.4 CXCL13 CD4
23 tabes dorsalis 10.4 CXCL13 CD4
24 t-cell/histiocyte rich large b cell lymphoma 10.4 TNFRSF8 MME BCL6
25 thyrotoxic exophthalmos 10.4 MME CD5
26 tertiary neurosyphilis 10.4 CXCL13 CD4
27 follicular mucinosis 10.4 TNFRSF8 CD4
28 meningovascular neurosyphilis 10.4 CXCL13 CD4
29 anal carcinoma in situ 10.4 MYC CD4
30 infected hydrocele 10.4 TNFRSF8 CD79A
31 reticulum cell sarcoma 10.4 TNFRSF8 CD4
32 paranasal sinus lymphoma 10.4 TNFRSF8 CD79A BCL6
33 tertiary syphilis 10.4 CXCL13 CD4
34 cerebral lymphoma 10.4 TNFRSF8 CD79A CD4
35 dendritic cell thymoma 10.4 CD5 CD4
36 lymphosarcoma 10.4 TNFRSF8 BCL6
37 hodgkin's lymphoma, mixed cellularity 10.4 TNFRSF8 CD79A
38 primary central nervous system lymphoma 10.4 MYD88 CXCL13 BCL6
39 pleural empyema 10.4 TNFRSF8 CD79A CD4
40 endocrine exophthalmos 10.4 MME CD5
41 mediastinal malignant lymphoma 10.4 TNFRSF8 KDM4C CD79A
42 mediastinal gray zone lymphoma 10.4 TNFRSF8 KDM4C CD79A
43 agammaglobulinemia, non-bruton type 10.4 CD79B CD79A
44 congenital syphilis 10.4 CD79A CD4
45 plasmablastic lymphoma 10.4 MYC BCL6
46 hodgkin's lymphoma, lymphocytic depletion 10.3 TNFRSF8 IGHV4-38-2 CD79A
47 combined thymoma 10.3 CD5 CD4
48 primary cutaneous diffuse large b-cell lymphoma, leg type 10.3 MYD88 MYC IRF4
49 anemia, autoimmune hemolytic 10.3 IGHV4-38-2 CD5 CD4
50 sclerosing hepatic carcinoma 10.3 MME CD79A CD5

Graphical network of the top 20 diseases related to Central Nervous System Hematologic Cancer:



Diseases related to Central Nervous System Hematologic Cancer

Symptoms & Phenotypes for Central Nervous System Hematologic Cancer

MGI Mouse Phenotypes related to Central Nervous System Hematologic Cancer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.93 BCL6 CD4 CD5 CD79A CD79B CXCL13
2 immune system MP:0005387 9.77 BCL6 CD4 CD5 CD79A CD79B CXCL13
3 no phenotypic analysis MP:0003012 9.23 BCL6 CD4 CD5 CD79A CD79B KDM4C

Drugs & Therapeutics for Central Nervous System Hematologic Cancer

Search Clinical Trials , NIH Clinical Center for Central Nervous System Hematologic Cancer

Genetic Tests for Central Nervous System Hematologic Cancer

Anatomical Context for Central Nervous System Hematologic Cancer

The Foundational Model of Anatomy Ontology organs/tissues related to Central Nervous System Hematologic Cancer:

19
Central Nervous System

MalaCards organs/tissues related to Central Nervous System Hematologic Cancer:

40
B Cells, T Cells, Lung, Breast, Bone, Colon, Eye

Publications for Central Nervous System Hematologic Cancer

Variations for Central Nervous System Hematologic Cancer

Expression for Central Nervous System Hematologic Cancer

Search GEO for disease gene expression data for Central Nervous System Hematologic Cancer.

Pathways for Central Nervous System Hematologic Cancer

GO Terms for Central Nervous System Hematologic Cancer

Cellular components related to Central Nervous System Hematologic Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 external side of plasma membrane GO:0009897 9.35 IGHV4-38-2 CD79B CD79A CD5 CD4
2 B cell receptor complex GO:0019815 8.62 CD79B CD79A

Biological processes related to Central Nervous System Hematologic Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.67 MYC IRF4 CD4 BCL6
2 B cell differentiation GO:0030183 9.43 CD79B CD79A BCL6
3 immune system process GO:0002376 9.43 MYD88 IRF4 CD79B CD79A CD4 BCL6
4 positive regulation of interleukin-2 biosynthetic process GO:0045086 9.32 IRF4 CD4
5 germinal center formation GO:0002467 9.16 CXCL13 BCL6
6 cell surface receptor signaling pathway GO:0007166 9.02 MYD88 CXCL13 CD79B CD79A CD4

Molecular functions related to Central Nervous System Hematologic Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 transmembrane signaling receptor activity GO:0004888 9.02 TNFRSF8 CD79B CD79A CD5 CD4

Sources for Central Nervous System Hematologic Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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