MCID: CNT018
MIFTS: 35

Central Nervous System Leukemia

Categories: Blood diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Leukemia

MalaCards integrated aliases for Central Nervous System Leukemia:

Name: Central Nervous System Leukemia 12 15 74
Leukemia of the Cns 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12969
NCIt 51 C5440
UMLS 74 C1332884

Summaries for Central Nervous System Leukemia

Disease Ontology : 12 A hematologic cancer located in the central nervous system.

MalaCards based summary : Central Nervous System Leukemia, also known as leukemia of the cns, is related to leukemia, acute lymphoblastic and leukemia. An important gene associated with Central Nervous System Leukemia is AFDN (Afadin, Adherens Junction Formation Factor), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Hematopoietic cell lineage. The drugs leucovorin and Methotrexate have been mentioned in the context of this disorder. Affiliated tissues include bone, b cells and myeloid, and related phenotype is Synthetic lethal with vaccinia virus (VACV) infection.

Related Diseases for Central Nervous System Leukemia

Graphical network of the top 20 diseases related to Central Nervous System Leukemia:



Diseases related to Central Nervous System Leukemia

Symptoms & Phenotypes for Central Nervous System Leukemia

GenomeRNAi Phenotypes related to Central Nervous System Leukemia according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 8.92 AFDN CARTPT MME RUNX1T1

Drugs & Therapeutics for Central Nervous System Leukemia

Drugs for Central Nervous System Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 100)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
leucovorin Approved Phase 2, Phase 3,Phase 3,Phase 1 58-05-9 143 6006
2
Methotrexate Approved Phase 2, Phase 3,Phase 3,Phase 1 1959-05-2, 59-05-2 126941
3
Vincristine Approved, Investigational Phase 2, Phase 3,Phase 3 2068-78-2, 57-22-7 5978
4
Mercaptopurine Approved Phase 2, Phase 3,Phase 3 50-44-2 667490
5
Dexamethasone Approved, Investigational, Vet_approved Phase 2, Phase 3,Phase 3 50-02-2 5743
6
Prednisone Approved, Vet_approved Phase 2, Phase 3,Phase 3 53-03-2 5865
7
Cytarabine Approved, Experimental, Investigational Phase 2, Phase 3,Phase 3,Phase 1 147-94-4, 65-46-3 6253
8
Idarubicin Approved Phase 2, Phase 3,Phase 3 58957-92-9 42890
9
Etoposide Approved Phase 2, Phase 3,Phase 3 33419-42-0 36462
10
Doxorubicin Approved, Investigational Phase 2, Phase 3,Phase 3 23214-92-8 31703
11
Cyclophosphamide Approved, Investigational Phase 2, Phase 3,Phase 3 50-18-0, 6055-19-2 2907
12
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 2, Phase 3,Phase 3 1177-87-3
13
Pegaspargase Approved, Investigational Phase 2, Phase 3,Phase 3,Phase 1 130167-69-0
14
Hydrocortisone Approved, Vet_approved Phase 3,Phase 1 50-23-7 5754
15
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
16
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
17
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
18
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
19
Hydrocortisone acetate Approved, Vet_approved Phase 3,Phase 1 50-03-3
20
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
21
Daunorubicin Approved Phase 3 20830-81-3 30323
22
Dasatinib Approved, Investigational Phase 3 302962-49-8 3062316
23
Thioguanine Approved Phase 3 154-42-7 2723601
24
Ichthammol Approved Phase 3 8029-68-3
25
Clofarabine Approved, Investigational Phase 3 123318-82-1 119182
26
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 1 22916-47-8 4189
27
Mesna Approved, Investigational Phase 3 3375-50-6 598
28
Busulfan Approved, Investigational Phase 3 55-98-1 2478
29
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3 59-30-3 6037
30
Calcium Approved, Nutraceutical Phase 3 7440-70-2 271
31
Tyrosine Approved, Investigational, Nutraceutical Phase 3 60-18-4 6057
32
Doxil Approved June 1999 Phase 2, Phase 3,Phase 3 31703
33
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
34
Cortisone Experimental Phase 3 53-06-5 222786
35
Emodepside Investigational, Vet_approved Phase 3 155030-63-0
36 Immunosuppressive Agents Phase 2, Phase 3,Phase 3,Phase 1
37 Antimetabolites Phase 2, Phase 3,Phase 3
38 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3,Phase 3
39 Folate Phase 2, Phase 3,Phase 3
40 Vitamin B9 Phase 2, Phase 3,Phase 3
41 Antirheumatic Agents Phase 2, Phase 3,Phase 3,Phase 1
42 Vitamin B Complex Phase 2, Phase 3,Phase 3
43 Dermatologic Agents Phase 2, Phase 3,Phase 3
44 Folic Acid Antagonists Phase 2, Phase 3,Phase 3
45 Antineoplastic Agents, Phytogenic Phase 2, Phase 3,Phase 3
46 Antimetabolites, Antineoplastic Phase 2, Phase 3,Phase 3
47 Immunologic Factors Phase 2, Phase 3,Phase 3,Phase 1
48 Antimitotic Agents Phase 2, Phase 3,Phase 3
49 Protein Kinase Inhibitors Phase 3,Phase 2
50 Gastrointestinal Agents Phase 2, Phase 3,Phase 3

Interventional clinical trials:

(show all 12)
# Name Status NCT ID Phase Drugs
1 Precision Diagnosis Directing HDACi Chidamide Target Therapy for Adult ETP-ALL Recruiting NCT03553238 Phase 2, Phase 3 Chidamide;Dexamethasone;vincristine;Cyclophosphamide;Idarubicin;Pegaspargase;Adriamycin;Methotrexate;6-Mercaptopurine;Etoposide;Cytarabine
2 Precision Diagnosis Directing HDACi Chidamide Target Therapy for Adult T-LBL/ALL Recruiting NCT03564704 Phase 2, Phase 3 Dexamethasone;vincristine;Cyclophosphamide;Idarubicin;Pegaspargase;Adriamycin;Methotrexate;6-mercaptopurine.;Etoposide;Cytarabine;Chidamide
3 Treatment of Acute Lymphoblastic Leukemia in Children Active, not recruiting NCT00400946 Phase 3 asparaginase;cyclophosphamide;cytarabine;dexamethasone;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;pegaspargase;prednisolone;therapeutic hydrocortisone;vincristine sulfate
4 Inotuzumab Ozogamicin and Post-Induction Chemotherapy in Treating Patients With High-Risk B-ALL, Mixed Phenotype Acute Leukemia, and B-LLy Not yet recruiting NCT03959085 Phase 3 Cyclophosphamide;Cytarabine;Daunorubicin;Daunorubicin Hydrochloride;Dexamethasone;Doxorubicin;Doxorubicin Hydrochloride;Leucovorin;Leucovorin Calcium;Mercaptopurine;Methotrexate;Pegaspargase;Prednisolone;Thioguanine;Vincristine;Vincristine Sulfate
5 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations Suspended NCT02883049 Phase 3 Clofarabine;Cyclophosphamide;Cytarabine;Dasatinib;Daunorubicin Hydrochloride;Dexamethasone;Doxorubicin Hydrochloride;Etoposide;Hydrocortisone Sodium Succinate;Leucovorin Calcium;Mercaptopurine;Methotrexate;Pegaspargase;Prednisone;Thioguanine;Vincristine Sulfate
6 Chemotherapy With or Without Total-Body Irradiation Prior to Bone Marrow Transplantation in Treating Children With Acute Lymphoblastic Leukemia Terminated NCT00002961 Phase 3 cyclophosphamide;cyclosporine;etoposide;methotrexate;Busulfan;Mesna
7 Treatment of Philadelphia-Positive Acute Lymphocytic Leukemia (Ph+ ALL) in the Elderly With Imatinib Mesylate (STI571) and Chemotherapy. Unknown status NCT00149136 Phase 2 imatinib
8 Intrathecal Rituximab in Lymphoid Malignancies Involving Central Nervous System Terminated NCT01596127 Phase 1, Phase 2 Intrathecal Rituximab
9 CAR-T Therapy for Central Nervous System B-cell Acute Lymphocytic Leukemia Recruiting NCT03064269 Phase 1
10 Study of Sirolimus With PEG-Asparaginase in Acute Lymphoblastic Leukemia (ALL) Withdrawn NCT00957320 Phase 1 Sirolimus;PEG-asparaginase
11 Nausea and Vomiting in Children Receiving Chemotherapeautic Monotherapy Unknown status NCT01661413
12 Study of Information Received About Fertility and Infertility in Patients Who Have Finished Treatment for Cancer Unknown status NCT01295463

Search NIH Clinical Center for Central Nervous System Leukemia

Genetic Tests for Central Nervous System Leukemia

Anatomical Context for Central Nervous System Leukemia

MalaCards organs/tissues related to Central Nervous System Leukemia:

42
Bone, B Cells, Myeloid, Bone Marrow, T Cells, Brain

The Foundational Model of Anatomy Ontology organs/tissues related to Central Nervous System Leukemia:

20
The Central Nervous System

Publications for Central Nervous System Leukemia

Articles related to Central Nervous System Leukemia:

(show top 50) (show all 74)
# Title Authors Year
1
Eradication of Central Nervous System Leukemia of T-Cell Origin with a Brain-Permeable LSD1 Inhibitor. ( 30518632 )
2019
2
Anti-CD19 CAR-T as a feasible and safe treatment against central nervous system leukemia after intrathecal chemotherapy in adults with relapsed or refractory B-ALL. ( 30846865 )
2019
3
Experiment research of focused ultrasound combined with drug and microbubble for treatment of central nervous system leukemia. ( 29435190 )
2018
4
Radiation in Central Nervous System Leukemia: Guidelines From the International Lymphoma Radiation Oncology Group. ( 30102203 )
2018
5
Rhabdomyolysis during myelosuppression in a patient with central nervous system leukemia: A case report. ( 30407314 )
2018
6
Chronic myeloid leukemia extramedullary blast crisis presenting as central nervous system leukemia: A case report. ( 30407337 )
2018
7
Central nervous system leukemia in a patient with concurrent nasopharyngeal carcinoma and acute myeloid leukaemia: A case report. ( 29384905 )
2017
8
Establishment of NOD/SCID mouse model of central nervous system leukemia. ( 24927394 )
2014
9
Comprehensive craniospinal radiation for controlling central nervous system leukemia. ( 25539370 )
2014
10
Does VEGF secreted by leukemic cells increase the permeability of blood-brain barrier by disrupting tight-junction proteins in central nervous system leukemia? ( 21398042 )
2011
11
Predictive role of cerebrospinal fluid hydrogen sulfide in central nervous system leukemia. ( 22340157 )
2011
12
Controversies in the management of central nervous system leukemia. ( 20469977 )
2010
13
[Central nervous system leukemia mimicking rapidly progressive HTLV-1 associated myelopathy]. ( 19491526 )
2009
14
Central nervous system leukemia on magnetic resonance imaging. ( 18310989 )
2008
15
Prophylaxis of central nervous system leukemia: a case of chronic myeloid leukemia with lymphoid blast crisis treated with imatinib mesylate. ( 18661773 )
2008
16
Primary central nervous system leukemia presenting with an isolated oculomotor palsy. ( 18710807 )
2008
17
Remission of Philadelphia chromosome-positive central nervous system leukemia after dasatinib therapy. ( 17487757 )
2007
18
Childhood central nervous system leukemia: historical perspectives, current therapy, and acute neurological sequelae. ( 17924103 )
2007
19
Detection of central nervous system leukemia in children with acute lymphoblastic leukemia by real-time polymerase chain reaction. ( 15681484 )
2005
20
Bilateral optic nerve infiltration in central nervous system leukemia. ( 12504706 )
2003
21
Risk and prognosis of central nervous system leukemia in patients with Philadelphia chromosome-positive acute leukemias treated with imatinib mesylate. ( 14581336 )
2003
22
Central nervous system leukemia recurring over more than 16 years. ( 10797368 )
2000
23
Primary central nervous system leukemia with a novel chromosomal translocation. ( 9335020 )
1997
24
Central nervous system leukemia. ( 8868094 )
1996
25
Biotherapy for xenografted human central nervous system leukemia in mice with severe combined immunodeficiency using B43 (anti-CD19)-pokeweed antiviral protein immunotoxin. ( 7537120 )
1995
26
The role of systemic high-dose cytarabine in the treatment of central nervous system leukemia. Clinical results in 46 patients. ( 8319175 )
1993
27
Cerebrospinal fluid neopterin levels in children with central nervous system leukemia. ( 8348070 )
1993
28
Temporal bone findings in central nervous system leukemia. ( 1812774 )
1991
29
Tumor necrosis factor in the cerebrospinal fluid of children with central nervous system leukemia. ( 1901928 )
1991
30
Effective prevention of central nervous system leukemia with intrathecal methotrexate and intrathecal methotrexate, cytosine arabinoside, and hydrocortisone in childhood acute lymphocytic leukemia. ( 2323651 )
1990
31
Therapy of central nervous system leukemia in mice by liposome-entrapped 1-beta-D-arabinofuranosylcytosine. ( 2766280 )
1989
32
Identification of risk groups for development of central nervous system leukemia in adults with acute lymphocytic leukemia. ( 3052630 )
1988
33
Central nervous system leukemia. ( 3047654 )
1988
34
Significance of cerebrospinal fluid ferritin estimation in central nervous system leukemia. ( 3113843 )
1987
35
Elevation of cerebrospinal fluid sialic acid concentration in children with central nervous system leukemia. ( 3296627 )
1987
36
Intermittent central nervous system irradiation and intrathecal chemotherapy for central nervous system leukemia in children. ( 3624023 )
1987
37
Millipore filter vs cytocentrifuge for detection of childhood central nervous system leukemia. ( 2425776 )
1986
38
Pickwickian syndrome related to central nervous system leukemia. ( 3458358 )
1986
39
Central nervous system leukemia in children with acute nonlymphoblastic leukemia. ( 3840394 )
1985
40
A unique pattern of central nervous system leukemia in acute myelomonocytic leukemia associated with inv(16)(p13q22). ( 3857943 )
1985
41
The central nervous system leukemia: a clinical and pathological study. ( 3860195 )
1985
42
Sequential combination of systemic high-dose ara-C and asparaginase for the treatment of central nervous system leukemia and lymphoma. ( 6366149 )
1984
43
Intrathecal methotrexate versus central nervous system leukemia. ( 6399986 )
1984
44
Recognition of central nervous system leukemia by flow cytometry. ( 6596184 )
1984
45
Reduction in central nervous system leukemia with a pharmacokinetically derived intrathecal methotrexate dosage regimen. ( 6366138 )
1983
46
Aziridinylbenzoquinone (AZQ) treatment of central nervous system leukemia. ( 6958367 )
1982
47
Diabetes insipidus associated with central nervous system leukemia. ( 7123345 )
1982
48
Central nervous system leukemia and lymphoma: computed tomographic manifestations. ( 6976091 )
1981
49
Intraventricular versus intralumbar methotrexate for central-nervous-system leukemia: prolonged remission with the Ommaya reservoir. ( 288969 )
1979
50
Scanning electron microscopic study on central nervous system leukemia in children. ( 292293 )
1979

Variations for Central Nervous System Leukemia

Expression for Central Nervous System Leukemia

Search GEO for disease gene expression data for Central Nervous System Leukemia.

Pathways for Central Nervous System Leukemia

Pathways related to Central Nervous System Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.32 CD19 MME
2 11.14 CD19 MME
3 10.82 CD19 MME
4 10.35 CD19 MME

GO Terms for Central Nervous System Leukemia

Sources for Central Nervous System Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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