MCID: CNT018
MIFTS: 37

Central Nervous System Leukemia

Categories: Cancer diseases, Immune diseases, Blood diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Leukemia

MalaCards integrated aliases for Central Nervous System Leukemia:

Name: Central Nervous System Leukemia 12 15 73
Leukemia of the Cns 12

Classifications:



External Ids:

Disease Ontology 12 DOID:12969
NCIt 50 C5440
UMLS 73 C1332884

Summaries for Central Nervous System Leukemia

Disease Ontology : 12 A hematologic cancer located in the central nervous system.

MalaCards based summary : Central Nervous System Leukemia, also known as leukemia of the cns, is related to acute lymphocytic leukemia and acute lymphoblastic leukemia, childhood. An important gene associated with Central Nervous System Leukemia is AFDN (Afadin, Adherens Junction Formation Factor), and among its related pathways/superpathways are Tight junction and Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers. The drugs Methotrexate and Vincristine have been mentioned in the context of this disorder. Affiliated tissues include the central nervous system, bone and b cells, and related phenotype is Synthetic lethal with vaccinia virus (VACV) infection.

Related Diseases for Central Nervous System Leukemia

Graphical network of the top 20 diseases related to Central Nervous System Leukemia:



Diseases related to Central Nervous System Leukemia

Symptoms & Phenotypes for Central Nervous System Leukemia

GenomeRNAi Phenotypes related to Central Nervous System Leukemia according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Synthetic lethal with vaccinia virus (VACV) infection GR00362-A 8.8 AFDN MME RUNX1

Drugs & Therapeutics for Central Nervous System Leukemia

Drugs for Central Nervous System Leukemia (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 92)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Methotrexate Approved Phase 3,Phase 1 1959-05-2, 59-05-2 126941
2
Vincristine Approved, Investigational Phase 3 2068-78-2, 57-22-7 5978
3
Clofarabine Approved, Investigational Phase 3 123318-82-1 119182
4
Cortisone acetate Approved, Investigational Phase 3 1950-04-4, 50-04-4 5745
5
Cyclophosphamide Approved, Investigational Phase 3 50-18-0, 6055-19-2 2907
6
Cytarabine Approved, Investigational Phase 3,Phase 1 147-94-4 6253
7
Dasatinib Approved, Investigational Phase 3 302962-49-8 3062316
8
Dexamethasone Approved, Investigational, Vet_approved Phase 3 50-02-2 5743
9
Doxorubicin Approved, Investigational Phase 3 23214-92-8 31703
10
Etoposide Approved Phase 3 33419-42-0 36462
11
Hydrocortisone Approved, Vet_approved Phase 3,Phase 1 50-23-7 5754
12
Levoleucovorin Approved, Investigational Phase 3 68538-85-2
13
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
14
Pegaspargase Approved, Investigational Phase 3,Phase 1 130167-69-0
15
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
16
Prednisone Approved, Vet_approved Phase 3 53-03-2 5865
17
Thioguanine Approved Phase 3 154-42-7 2723601
18
Busulfan Approved, Investigational Phase 3 55-98-1 2478
19
Mesna Approved, Investigational Phase 3 3375-50-6 598
20
Miconazole Approved, Investigational, Vet_approved Phase 3,Phase 1 22916-47-8 4189
21
Folic Acid Approved, Nutraceutical, Vet_approved Phase 3 59-30-3 6037
22
leucovorin Approved, Nutraceutical Phase 3,Phase 1 58-05-9 143 6006
23
Butyric Acid Experimental, Investigational Phase 3 107-92-6 264
24
Doxil Approved June 1999 Phase 3 31703
25 6-Mercaptopurine Phase 3
26 Antimetabolites Phase 3
27 Antimetabolites, Antineoplastic Phase 3
28 Antimitotic Agents Phase 3
29 Antineoplastic Agents, Phytogenic Phase 3
30 Antirheumatic Agents Phase 3,Phase 1,Phase 2
31 Dermatologic Agents Phase 3
32 Folic Acid Antagonists Phase 3
33 Immunosuppressive Agents Phase 3,Phase 1
34 Nucleic Acid Synthesis Inhibitors Phase 3
35 Protein Kinase Inhibitors Phase 3,Phase 2
36 Vitamin B Complex Phase 3
37 2-Aminopurine Phase 3
38 Alkylating Agents Phase 3
39 Anti-Bacterial Agents Phase 3,Phase 1
40 Antibiotics, Antitubercular Phase 3,Phase 1
41 Antidotes Phase 3
42 Antiemetics Phase 3
43 Anti-Infective Agents Phase 3,Phase 1
44 Anti-Inflammatory Agents Phase 3
45 Antineoplastic Agents, Alkylating Phase 3
46 Antineoplastic Agents, Hormonal Phase 3
47 Antiviral Agents Phase 3
48
asparaginase Phase 3,Phase 1
49 Autonomic Agents Phase 3
50 BB 1101 Phase 3

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Combination Chemotherapy in Treating Young Patients With Newly Diagnosed High-Risk B Acute Lymphoblastic Leukemia and Ph-Like TKI Sensitive Mutations Recruiting NCT02883049 Phase 3 Clofarabine;Cyclophosphamide;Cytarabine;Dasatinib;Dexamethasone;Doxorubicin Hydrochloride;Etoposide;Hydrocortisone Sodium Succinate;Leucovorin Calcium;Mercaptopurine;Methotrexate;Pegaspargase;Prednisone;Thioguanine;Vincristine Sulfate
2 Precision Diagnosis Directing HDACi Chidamide Target Therapy for Adult ETP-ALL Recruiting NCT03553238 Phase 2, Phase 3 Chidamide;Dexamethasone;vincristine;Cyclophosphamide;Idarubicin;Pegaspargase;Adriamycin;Methotrexate;6-Mercaptopurine;Etoposide;Cytarabine
3 Precision Diagnosis Directing HDACi Chidamide Target Therapy for Adult T-LBL/ALL Recruiting NCT03564704 Phase 2, Phase 3 Dexamethasone;vincristine;Cyclophosphamide;Idarubicin;Pegaspargase;Adriamycin;Methotrexate;6-mercaptopurine.;Etoposide;Cytarabine;Chidamide
4 Treatment of Acute Lymphoblastic Leukemia in Children Active, not recruiting NCT00400946 Phase 3 asparaginase;cyclophosphamide;cytarabine;dexamethasone;dexrazoxane hydrochloride;doxorubicin hydrochloride;etoposide;leucovorin calcium;mercaptopurine;methotrexate;methylprednisolone;pegaspargase;prednisolone;therapeutic hydrocortisone;vincristine sulfate
5 Chemotherapy With or Without Total-Body Irradiation Prior to Bone Marrow Transplantation in Treating Children With Acute Lymphoblastic Leukemia Terminated NCT00002961 Phase 3 cyclophosphamide;cyclosporine;etoposide;methotrexate;Busulfan;Mesna
6 Treatment of Philadelphia-Positive Acute Lymphocytic Leukemia (Ph+ ALL) in the Elderly With Imatinib Mesylate (STI571) and Chemotherapy. Unknown status NCT00149136 Phase 2 imatinib
7 Intrathecal Rituximab in Lymphoid Malignancies Involving Central Nervous System Terminated NCT01596127 Phase 1, Phase 2 Intrathecal Rituximab
8 CAR-T Therapy for Central Nervous System B-cell Acute Lymphocytic Leukemia Recruiting NCT03064269 Phase 1
9 Study of Sirolimus With PEG-Asparaginase in Acute Lymphoblastic Leukemia (ALL) Withdrawn NCT00957320 Phase 1 Sirolimus;PEG-asparaginase
10 Nausea and Vomiting in Children Receiving Chemotherapeautic Monotherapy Unknown status NCT01661413
11 Study of Information Received About Fertility and Infertility in Patients Who Have Finished Treatment for Cancer Unknown status NCT01295463

Search NIH Clinical Center for Central Nervous System Leukemia

Genetic Tests for Central Nervous System Leukemia

Anatomical Context for Central Nervous System Leukemia

The Foundational Model of Anatomy Ontology organs/tissues related to Central Nervous System Leukemia:

19
The Central Nervous System

MalaCards organs/tissues related to Central Nervous System Leukemia:

41
Bone, B Cells, Bone Marrow, Myeloid, Brain

Publications for Central Nervous System Leukemia

Articles related to Central Nervous System Leukemia:

(show top 50) (show all 67)
# Title Authors Year
1
Experiment research of focused ultrasound combined with drug and microbubble for treatment of central nervous system leukemia. ( 29435190 )
2018
2
Central nervous system leukemia in a patient with concurrent nasopharyngeal carcinoma and acute myeloid leukaemia: A case report. ( 29384905 )
2017
3
Establishment of NOD/SCID mouse model of central nervous system leukemia. ( 24927394 )
2014
4
Comprehensive craniospinal radiation for controlling central nervous system leukemia. ( 25539370 )
2014
5
Does VEGF secreted by leukemic cells increase the permeability of blood-brain barrier by disrupting tight-junction proteins in central nervous system leukemia? ( 21398042 )
2011
6
Predictive role of cerebrospinal fluid hydrogen sulfide in central nervous system leukemia. ( 22340157 )
2011
7
Controversies in the management of central nervous system leukemia. ( 20469977 )
2010
8
[Central nervous system leukemia mimicking rapidly progressive HTLV-1 associated myelopathy]. ( 19491526 )
2009
9
Primary central nervous system leukemia presenting with an isolated oculomotor palsy. ( 18710807 )
2008
10
Prophylaxis of central nervous system leukemia: a case of chronic myeloid leukemia with lymphoid blast crisis treated with imatinib mesylate. ( 18661773 )
2008
11
Central nervous system leukemia on magnetic resonance imaging. ( 18310989 )
2008
12
Remission of Philadelphia chromosome-positive central nervous system leukemia after dasatinib therapy. ( 17487757 )
2007
13
Childhood central nervous system leukemia: historical perspectives, current therapy, and acute neurological sequelae. ( 17924103 )
2007
14
Detection of central nervous system leukemia in children with acute lymphoblastic leukemia by real-time polymerase chain reaction. ( 15681484 )
2005
15
Risk and prognosis of central nervous system leukemia in patients with Philadelphia chromosome-positive acute leukemias treated with imatinib mesylate. ( 14581336 )
2003
16
Bilateral optic nerve infiltration in central nervous system leukemia. ( 12504706 )
2003
17
Central nervous system leukemia recurring over more than 16 years. ( 10797368 )
2000
18
Primary central nervous system leukemia with a novel chromosomal translocation. ( 9335020 )
1997
19
Central nervous system leukemia. ( 8868094 )
1996
20
Biotherapy for xenografted human central nervous system leukemia in mice with severe combined immunodeficiency using B43 (anti-CD19)-pokeweed antiviral protein immunotoxin. ( 7537120 )
1995
21
The role of systemic high-dose cytarabine in the treatment of central nervous system leukemia. Clinical results in 46 patients. ( 8319175 )
1993
22
Cerebrospinal fluid neopterin levels in children with central nervous system leukemia. ( 8348070 )
1993
23
Temporal bone findings in central nervous system leukemia. ( 1812774 )
1991
24
Tumor necrosis factor in the cerebrospinal fluid of children with central nervous system leukemia. ( 1901928 )
1991
25
Effective prevention of central nervous system leukemia with intrathecal methotrexate and intrathecal methotrexate, cytosine arabinoside, and hydrocortisone in childhood acute lymphocytic leukemia. ( 2323651 )
1990
26
Central nervous system leukemia. ( 3047654 )
1988
27
Identification of risk groups for development of central nervous system leukemia in adults with acute lymphocytic leukemia. ( 3052630 )
1988
28
Elevation of cerebrospinal fluid sialic acid concentration in children with central nervous system leukemia. ( 3296627 )
1987
29
Significance of cerebrospinal fluid ferritin estimation in central nervous system leukemia. ( 3113843 )
1987
30
Intermittent central nervous system irradiation and intrathecal chemotherapy for central nervous system leukemia in children. ( 3624023 )
1987
31
Pickwickian syndrome related to central nervous system leukemia. ( 3458358 )
1986
32
Millipore filter vs cytocentrifuge for detection of childhood central nervous system leukemia. ( 2425776 )
1986
33
The central nervous system leukemia: a clinical and pathological study. ( 3860195 )
1985
34
A unique pattern of central nervous system leukemia in acute myelomonocytic leukemia associated with inv(16)(p13q22). ( 3857943 )
1985
35
Central nervous system leukemia in children with acute nonlymphoblastic leukemia. ( 3840394 )
1985
36
Intrathecal methotrexate versus central nervous system leukemia. ( 6399986 )
1984
37
Sequential combination of systemic high-dose ara-C and asparaginase for the treatment of central nervous system leukemia and lymphoma. ( 6366149 )
1984
38
Recognition of central nervous system leukemia by flow cytometry. ( 6596184 )
1984
39
Reduction in central nervous system leukemia with a pharmacokinetically derived intrathecal methotrexate dosage regimen. ( 6366138 )
1983
40
Diabetes insipidus associated with central nervous system leukemia. ( 7123345 )
1982
41
Aziridinylbenzoquinone (AZQ) treatment of central nervous system leukemia. ( 6958367 )
1982
42
Central nervous system leukemia and lymphoma: computed tomographic manifestations. ( 6976091 )
1981
43
Intraventricular versus intralumbar methotrexate for central-nervous-system leukemia: prolonged remission with the Ommaya reservoir. ( 288969 )
1979
44
Scanning electron microscopic study on central nervous system leukemia in children. ( 292293 )
1979
45
Central nervous system leukemia. ( 267618 )
1977
46
Antimetaboliths in the prophylaxis and treatment of central nervous system leukemia. ( 267507 )
1977
47
Cerebrospinal fluid polyamine monitoring in central nervous system leukemia. ( 852128 )
1977
48
Central nervous system leukemia in childhood. ( 927864 )
1977
49
The value of maintenance therapy following treatment of central nervous system leukemia. ( 332318 )
1977
50
Preventing central nervous system leukemia. ( 990041 )
1976

Variations for Central Nervous System Leukemia

Expression for Central Nervous System Leukemia

Search GEO for disease gene expression data for Central Nervous System Leukemia.

Pathways for Central Nervous System Leukemia

Pathways related to Central Nervous System Leukemia according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.6 AFDN RUNX1
2 11.39 CD19 MME
3 11.13 CD19 MME
4 11.02 CR1 MME
5 10.79 CD19 CR1 MME
6 10.68 CD19 MME

GO Terms for Central Nervous System Leukemia

Cellular components related to Central Nervous System Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 secretory granule membrane GO:0030667 8.62 CR1 MME

Biological processes related to Central Nervous System Leukemia according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of complement activation GO:0030449 9.16 CD19 CR1
2 neutrophil degranulation GO:0043312 9.13 CDA CR1 MME
3 regulation of regulatory T cell differentiation GO:0045589 8.62 CR1 RUNX1

Sources for Central Nervous System Leukemia

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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