MCID: CNT024
MIFTS: 24

Central Nervous System Lipoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Lipoma

MalaCards integrated aliases for Central Nervous System Lipoma:

Name: Central Nervous System Lipoma 12 15
Lipoma of the Cns 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6293
NCIt 50 C5451
UMLS 72 C1332885

Summaries for Central Nervous System Lipoma

Disease Ontology : 12 A central nervous system benign neoplasm that derives from fat cells.

MalaCards based summary : Central Nervous System Lipoma, also known as lipoma of the cns, is related to encephalocraniocutaneous lipomatosis and spinal cord lipoma. An important gene associated with Central Nervous System Lipoma is ALX3 (ALX Homeobox 3), and among its related pathways/superpathways are HIV Life Cycle and p70S6K Signaling. Related phenotypes are Transferrin accumulation in the perinuclear area and cellular

Related Diseases for Central Nervous System Lipoma

Diseases related to Central Nervous System Lipoma via text searches within MalaCards or GeneCards Suite gene sharing:

# Related Disease Score Top Affiliating Genes
1 encephalocraniocutaneous lipomatosis 11.7
2 spinal cord lipoma 11.4
3 lipomatosis, multiple 10.0
4 pleomorphic lipoma 10.0
5 lipomatosis 10.0
6 crouzon syndrome 9.7 FGFR1 ALX3
7 corpus callosum lipoma 9.6 MAP2K1 ALX3
8 cerebral hemisphere lipoma 9.5 MAP2K1 ALX3
9 achondroplasia 9.2 MAP2K1 FGFR1

Graphical network of the top 20 diseases related to Central Nervous System Lipoma:



Diseases related to Central Nervous System Lipoma

Symptoms & Phenotypes for Central Nervous System Lipoma

GenomeRNAi Phenotypes related to Central Nervous System Lipoma according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Transferrin accumulation in the perinuclear area GR00356-A-3 8.62 FGFR1 MAP2K1

MGI Mouse Phenotypes related to Central Nervous System Lipoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cellular MP:0005384 9.88 ALX3 FGFR1 FRS2 MAP2K1 RICTOR
2 embryo MP:0005380 9.83 ALX3 FGFR1 FRS2 MAP2K1 RICTOR
3 growth/size/body region MP:0005378 9.77 ALX3 FGFR1 FRS2 MAP2K1 RICTOR
4 craniofacial MP:0005382 9.76 ALX3 FGFR1 FRS2 MAP2K1
5 endocrine/exocrine gland MP:0005379 9.71 ALX3 FGFR1 MAP2K1 RICTOR
6 mortality/aging MP:0010768 9.65 ALX3 FGFR1 FRS2 MAP2K1 RICTOR
7 hearing/vestibular/ear MP:0005377 9.5 FGFR1 FRS2 MAP2K1
8 reproductive system MP:0005389 9.46 ALX3 FGFR1 MAP2K1 RICTOR
9 skeleton MP:0005390 9.35 ALX3 FGFR1 FRS2 MAP2K1 RICTOR
10 vision/eye MP:0005391 8.92 ALX3 FGFR1 FRS2 MAP2K1

Drugs & Therapeutics for Central Nervous System Lipoma

Search Clinical Trials , NIH Clinical Center for Central Nervous System Lipoma

Genetic Tests for Central Nervous System Lipoma

Anatomical Context for Central Nervous System Lipoma

Publications for Central Nervous System Lipoma

Articles related to Central Nervous System Lipoma:

# Title Authors PMID Year
1
Prenatal detection of Pai syndrome without cleft lip and palate: a case report. 38
23610859 2013
2
Epidermal nevus syndrome associated with polyostotic fibrous dysplasia, CNS lipoma, and aplasia cutis. 38
19951625 2009

Variations for Central Nervous System Lipoma

Expression for Central Nervous System Lipoma

Search GEO for disease gene expression data for Central Nervous System Lipoma.

Pathways for Central Nervous System Lipoma

Pathways related to Central Nervous System Lipoma according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.29 RICTOR MAP2K1 FRS2 FGFR1
2
Show member pathways
12.66 RICTOR MAP2K1 FGFR1
3
Show member pathways
12.33 RICTOR FRS2 FGFR1
4
Show member pathways
12.05 RICTOR MAP2K1 FGFR1
5
Show member pathways
11.96 MAP2K1 FRS2 FGFR1
6 11.79 FRS2 FGFR1
7 11.77 MAP2K1 FRS2
8 11.75 MAP2K1 FGFR1
9
Show member pathways
11.73 MAP2K1 FRS2 FGFR1
10
Show member pathways
11.73 RICTOR FRS2 FGFR1
11
Show member pathways
11.69 MAP2K1 FGFR1
12
Show member pathways
11.68 RICTOR MAP2K1 FGFR1
13 11.61 MAP2K1 FGFR1
14 11.58 RICTOR MAP2K1
15
Show member pathways
11.52 FRS2 FGFR1
16
Show member pathways
11.48 MAP2K1 FGFR1
17 11.39 MAP2K1 FGFR1
18
Show member pathways
11.32 MAP2K1 FRS2
19 11.3 RICTOR MAP2K1
20 11.18 FRS2 FGFR1
21 11.15 FRS2 FGFR1
22 11.11 MAP2K1 FRS2 FGFR1
23 11.09 MAP2K1 FGFR1
24 10.96 RICTOR MAP2K1
25 10.28 MAP2K1 FGFR1

GO Terms for Central Nervous System Lipoma

Biological processes related to Central Nervous System Lipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.33 MAP2K1 FRS2 FGFR1
2 activation of MAPK activity GO:0000187 9.32 MAP2K1 FRS2
3 fibroblast growth factor receptor signaling pathway GO:0008543 9.26 FRS2 FGFR1
4 positive regulation of protein kinase B signaling GO:0051897 9.13 RICTOR FRS2 FGFR1
5 organ induction GO:0001759 8.62 FRS2 FGFR1

Sources for Central Nervous System Lipoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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