MCID: CNT024
MIFTS: 21

Central Nervous System Lipoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Lipoma

MalaCards integrated aliases for Central Nervous System Lipoma:

Name: Central Nervous System Lipoma 12 15
Lipoma of the Cns 12

Classifications:



External Ids:

Disease Ontology 12 DOID:6293
NCIt 49 C5451
UMLS 71 C1332885

Summaries for Central Nervous System Lipoma

Disease Ontology : 12 A central nervous system benign neoplasm that derives from fat cells.

MalaCards based summary : Central Nervous System Lipoma, also known as lipoma of the cns, is related to spinal cord lipoma and lipomatosis, multiple. An important gene associated with Central Nervous System Lipoma is ALX3 (ALX Homeobox 3), and among its related pathways/superpathways are FGFR1 mutant receptor activation and Cell adhesion_Plasmin signaling. Related phenotypes are craniofacial and embryo

Related Diseases for Central Nervous System Lipoma

Diseases related to Central Nervous System Lipoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 39)
# Related Disease Score Top Affiliating Genes
1 spinal cord lipoma 32.1 FGFR1 COX8C
2 lipomatosis, multiple 29.8 FGFR1 ALX3
3 encephalocraniocutaneous lipomatosis 11.7
4 hemifacial microsomia 10.0 FGFR1 ALX3
5 pleomorphic lipoma 10.0
6 lipomatosis 10.0
7 holoprosencephaly 7 9.9 ZIC2 SIX3
8 holoprosencephaly 9 9.9 ZIC2 SIX3
9 midline interhemispheric variant of holoprosencephaly 9.9 ZIC2 SIX3
10 septopreoptic holoprosencephaly 9.9 ZIC2 SIX3
11 holoprosencephaly 1 9.9 ZIC2 SIX3
12 holoprosencephaly 5 9.9 ZIC2 SIX3
13 holoprosencephaly 2 9.9 ZIC2 SIX3
14 alobar holoprosencephaly 9.9 ZIC2 SIX3
15 holoprosencephaly 4 9.9 ZIC2 SIX3
16 holoprosencephaly 11 9.8 ZIC2 SIX3
17 solitary median maxillary central incisor 9.8 ZIC2 SIX3
18 saethre-chotzen syndrome 9.8 FGFR1 ALX3
19 holoprosencephaly 3 9.8 ZIC2 SIX3
20 patau syndrome 9.8 ZIC2 SIX3
21 orofaciodigital syndrome viii 9.8 ZIC2 SIX3
22 pallister-hall syndrome 9.8 ZIC2 SIX3
23 bone development disease 9.8 FGFR1 ALX3
24 anencephaly 9.7 ZIC2 SIX3
25 septooptic dysplasia 9.7 SIX3 FGFR1
26 achondroplasia, severe, with developmental delay and acanthosis nigricans 9.7 FRS2 FGFR1
27 thanatophoric dysplasia, type i 9.6 FRS2 FGFR1
28 physical disorder 9.6 ZIC2 SIX3 ALX3
29 synostosis 9.5 FGFR1 ALX3
30 congenital nervous system abnormality 9.5 ZIC2 SIX3
31 lobar holoprosencephaly 9.5 ZIC2 SIX3 FGFR1
32 microform holoprosencephaly 9.5 ZIC2 SIX3 FGFR1
33 semilobar holoprosencephaly 9.5 ZIC2 SIX3 FGFR1
34 crouzon syndrome 9.4 FRS2 FGFR1 ALX3
35 corpus callosum lipoma 9.2 ZIC2 SIX3 FGFR1 ALX3
36 cerebral hemisphere lipoma 9.2 ZIC2 SIX3 FGFR1 ALX3
37 holoprosencephaly 9.2 ZIC2 SIX3 FGFR1 ALX3
38 coloboma of macula 9.2 ZIC2 SIX3 FGFR1 ALX3
39 orofacial cleft 9.2 ZIC2 SIX3 FGFR1 ALX3

Graphical network of the top 20 diseases related to Central Nervous System Lipoma:



Diseases related to Central Nervous System Lipoma

Symptoms & Phenotypes for Central Nervous System Lipoma

MGI Mouse Phenotypes related to Central Nervous System Lipoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 craniofacial MP:0005382 9.8 ALX3 FGFR1 FRS2 SIX3 ZIC2
2 embryo MP:0005380 9.72 ALX3 FGFR1 FRS2 SIX3 ZIC2
3 digestive/alimentary MP:0005381 9.67 ALX3 FGFR1 SIX3 ZIC2
4 limbs/digits/tail MP:0005371 9.56 ALX3 FGFR1 FRS2 ZIC2
5 nervous system MP:0003631 9.55 ALX3 FGFR1 FRS2 SIX3 ZIC2
6 skeleton MP:0005390 9.35 ALX3 FGFR1 FRS2 SIX3 ZIC2
7 vision/eye MP:0005391 9.02 ALX3 FGFR1 FRS2 SIX3 ZIC2

Drugs & Therapeutics for Central Nervous System Lipoma

Search Clinical Trials , NIH Clinical Center for Central Nervous System Lipoma

Genetic Tests for Central Nervous System Lipoma

Anatomical Context for Central Nervous System Lipoma

Publications for Central Nervous System Lipoma

Articles related to Central Nervous System Lipoma:

# Title Authors PMID Year
1
Prenatal detection of Pai syndrome without cleft lip and palate: a case report. 61
23610859 2013
2
Epidermal nevus syndrome associated with polyostotic fibrous dysplasia, CNS lipoma, and aplasia cutis. 61
19951625 2009

Variations for Central Nervous System Lipoma

Expression for Central Nervous System Lipoma

Search GEO for disease gene expression data for Central Nervous System Lipoma.

Pathways for Central Nervous System Lipoma

Pathways related to Central Nervous System Lipoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.11 FRS2 FGFR1
2 10.65 FRS2 FGFR1
3 10.3 FRS2 FGFR1

GO Terms for Central Nervous System Lipoma

Biological processes related to Central Nervous System Lipoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.56 ZIC2 SIX3 FGFR1 ALX3
2 transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 9.37 FRS2 FGFR1
3 fibroblast growth factor receptor signaling pathway GO:0008543 9.32 FRS2 FGFR1
4 lens development in camera-type eye GO:0002088 9.16 SIX3 FRS2
5 brain development GO:0007420 9.13 ZIC2 SIX3 FGFR1
6 organ induction GO:0001759 8.62 FRS2 FGFR1

Sources for Central Nervous System Lipoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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