MCID: CNT041
MIFTS: 31

Central Nervous System Melanocytic Neoplasm

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Melanocytic Neoplasm

MalaCards integrated aliases for Central Nervous System Melanocytic Neoplasm:

Name: Central Nervous System Melanocytic Neoplasm 12 15 73
Central Nervous System Primary Melanocytic Lesion 12
Primary Melanocytic Lesion of Meninges 12
Primary Melanocytic Lesions of the Cns 12
Melanocytic Tumor of the Cns 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4955
NCIt 50 C4661 C5504
SNOMED-CT 68 277523004

Summaries for Central Nervous System Melanocytic Neoplasm

MalaCards based summary : Central Nervous System Melanocytic Neoplasm, also known as central nervous system primary melanocytic lesion, is related to phakomatosis cesioflammea and intraocular melanoma. An important gene associated with Central Nervous System Melanocytic Neoplasm is GNAQ (G Protein Subunit Alpha Q), and among its related pathways/superpathways are Aldosterone synthesis and secretion and Gastric cancer. Related phenotypes are Decreased viability and Decreased viability

Related Diseases for Central Nervous System Melanocytic Neoplasm

Diseases related to Central Nervous System Melanocytic Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 75)
# Related Disease Score Top Affiliating Genes
1 phakomatosis cesioflammea 11.0 GNA11 GNAQ
2 intraocular melanoma 11.0 GNA11 GNAQ
3 giant congenital nevus 10.9 HRAS NRAS
4 conjunctival cancer 10.8 GNA11 GNAQ NRAS
5 malignant ectomesenchymoma 10.7 ENO2 HRAS
6 benign struma ovarii 10.7 HRAS NRAS
7 schimmelpenning-feuerstein-mims syndrome 10.7 HRAS NRAS
8 ectomesenchymoma 10.7 ENO2 HRAS
9 thymoma, familial 10.6 HRAS KIT
10 liver angiosarcoma 10.6 ENO2 HRAS NRAS
11 sensory system cancer 10.6 CDKN2A GNA11 GNAQ
12 ocular cancer 10.6 CDKN2A GNA11 GNAQ
13 cutaneous ganglioneuroma 10.5 ENO2 KIT
14 melanocytic nevus syndrome, congenital 10.5 HRAS NRAS TYR
15 gallbladder adenoma 10.5 CDKN2A HRAS
16 malignant conjunctival melanoma 10.5 GNA11 GNAQ HRAS NRAS
17 melanoma, cutaneous malignant 1 10.4 CDKN2A HRAS NRAS
18 gastric leiomyosarcoma 10.4 ENO2 KIT YARS
19 differentiated thyroid carcinoma 10.4 CDKN2A HRAS NRAS
20 mongolian spot 10.4 ADAMTS1 ENO2 GNAQ
21 core binding factor acute myeloid leukemia 10.4 HRAS KIT NRAS
22 nervous system cancer 10.4 CDKN2A ENO2 GNA11 GNAQ
23 mixed cell type cancer 10.4 ENO2 HRAS KIT
24 endocrine gland cancer 10.4 CDKN2A ENO2 HRAS
25 dyschromatosis symmetrica hereditaria 10.4 HRAS TYR YARS
26 acral lentiginous melanoma 10.4 CDKN2A KIT NRAS
27 gallbladder melanoma 10.3 MLANA PMEL
28 renal cell carcinoma, papillary, 1 10.3 HRAS KIT NRAS
29 mucosal melanoma 10.3 GNA11 GNAQ KIT NRAS
30 gastrointestinal system benign neoplasm 10.2 CDKN2A HRAS KIT
31 transitional cell carcinoma 10.2 CDKN2A ENO2 HRAS
32 spitz nevus 10.2 CDKN2A HRAS
33 infiltrating angiolipoma 10.2 CDKN2A MLANA
34 gastrointestinal system cancer 10.1 CDKN2A HRAS KIT
35 acute kidney tubular necrosis 10.1 CDKN2A HGF TYR
36 malignant anus melanoma 10.1 KIT MLANA
37 epithelioid cell melanoma 10.1 ENO2 MLANA TYR
38 respiratory system cancer 10.1 CDKN2A ENO2 HRAS PDCD1
39 pigmented basal cell carcinoma 10.0 MLANA TYR
40 halo nevi 10.0 MLANA PMEL TYR
41 melanoacanthoma 10.0 MLANA PMEL TYR
42 axillary lipoma 10.0 CD68 KIT
43 fox-fordyce disease 9.9 CD68 KIT
44 myeloma, multiple 9.9 CDKN2A HGF HRAS NRAS
45 vitiligo-associated multiple autoimmune disease susceptibility 1 9.9 MLANA PMEL TYR
46 endometrial squamous cell carcinoma 9.9 CDKN2A HGF
47 extracutaneous mastocytoma 9.9 CD68 KIT
48 breast angiosarcoma 9.8 KIT MLANA TYR
49 verruciform xanthoma of skin 9.8 CD68 S100A9
50 nodular tenosynovitis 9.8 CD68 S100A9

Graphical network of the top 20 diseases related to Central Nervous System Melanocytic Neoplasm:



Diseases related to Central Nervous System Melanocytic Neoplasm

Symptoms & Phenotypes for Central Nervous System Melanocytic Neoplasm

GenomeRNAi Phenotypes related to Central Nervous System Melanocytic Neoplasm according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00055-A-2 9.6 HRAS
2 Decreased viability GR00221-A-1 9.6 CDKN2A HGF HRAS KIT NRAS
3 Decreased viability GR00221-A-2 9.6 HGF HRAS
4 Decreased viability GR00221-A-3 9.6 CDKN2A HRAS NRAS
5 Decreased viability GR00221-A-4 9.6 CDKN2A HGF
6 Decreased viability GR00301-A 9.6 KIT
7 Decreased viability GR00402-S-2 9.6 CDKN2A HGF HRAS KIT NRAS

MGI Mouse Phenotypes related to Central Nervous System Melanocytic Neoplasm:

46 (show all 13)
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.29 GNA11 HRAS ADAMTS1 GNAQ CDKN2A ENO2
2 homeostasis/metabolism MP:0005376 10.25 GNA11 ADAMTS1 GNAQ CDKN2A GPR180 NRAS
3 cardiovascular system MP:0005385 10.22 GNA11 GNAQ CDKN2A GPR180 HGF NRAS
4 mortality/aging MP:0010768 10.18 HGF GNA11 ADAMTS1 GNAQ CDKN2A NRAS
5 hematopoietic system MP:0005397 10.16 HGF GNA11 CD68 GNAQ CDKN2A NRAS
6 endocrine/exocrine gland MP:0005379 10.15 GNA11 ADAMTS1 GNAQ CDKN2A NRAS HRAS
7 integument MP:0010771 10.06 GNA11 GNAQ CDKN2A KIT PMEL MLANA
8 craniofacial MP:0005382 10.05 GNA11 GNAQ ENO2 NRAS HRAS KIT
9 no phenotypic analysis MP:0003012 9.97 HRAS CD68 CDKN2A HGF KIT PMEL
10 pigmentation MP:0001186 9.86 GNAQ CDKN2A GNA11 KIT PMEL MLANA
11 renal/urinary system MP:0005367 9.7 GNA11 ADAMTS1 GNAQ HRAS PDCD1 KIT
12 respiratory system MP:0005388 9.5 GNA11 GNAQ CDKN2A ENO2 HRAS PDCD1
13 skeleton MP:0005390 9.32 GNA11 HRAS CD68 GNAQ CDKN2A PDCD1

Drugs & Therapeutics for Central Nervous System Melanocytic Neoplasm

Search Clinical Trials , NIH Clinical Center for Central Nervous System Melanocytic Neoplasm

Genetic Tests for Central Nervous System Melanocytic Neoplasm

Anatomical Context for Central Nervous System Melanocytic Neoplasm

Publications for Central Nervous System Melanocytic Neoplasm

Variations for Central Nervous System Melanocytic Neoplasm

Expression for Central Nervous System Melanocytic Neoplasm

Search GEO for disease gene expression data for Central Nervous System Melanocytic Neoplasm.

Pathways for Central Nervous System Melanocytic Neoplasm

Pathways related to Central Nervous System Melanocytic Neoplasm according to GeneCards Suite gene sharing:

(show all 16)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.73 CDKN2A GNA11 GNAQ HRAS KIT NRAS
2
Show member pathways
12.57 CDKN2A HGF HRAS KIT NRAS
3
Show member pathways
12.53 GNAQ HGF HRAS KIT NRAS
4 11.89 CDKN2A GNA11 GNAQ HGF HRAS KIT
5
Show member pathways
11.63 HRAS KIT NRAS
6 11.56 CDKN2A HRAS NRAS
7 11.5 GNA11 GNAQ HRAS NRAS
8 11.47 HRAS KIT NRAS
9 11.45 GNA11 GNAQ HRAS
10 11.14 GNA11 GNAQ HGF
11 11.08 GNA11 GNAQ HRAS NRAS
12 11.06 HGF HRAS NRAS
13 11.03 GNA11 GNAQ HRAS NRAS
14
Show member pathways
10.76 GNA11 GNAQ
15 10.66 HRAS NRAS
16 10.63 GNAQ HRAS NRAS

GO Terms for Central Nervous System Melanocytic Neoplasm

Cellular components related to Central Nervous System Melanocytic Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 melanosome GO:0042470 8.8 MLANA PMEL TYR

Biological processes related to Central Nervous System Melanocytic Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 MAPK cascade GO:0000165 9.73 HGF HRAS KIT NRAS
2 G-protein coupled acetylcholine receptor signaling pathway GO:0007213 9.48 GNA11 GNAQ
3 phospholipase C-activating dopamine receptor signaling pathway GO:0060158 9.46 GNA11 GNAQ
4 melanin biosynthetic process GO:0042438 9.4 PMEL TYR
5 somatic stem cell division GO:0048103 9.37 CDKN2A KIT
6 phototransduction, visible light GO:0007603 9.32 GNA11 GNAQ
7 entrainment of circadian clock GO:0009649 9.26 GNA11 GNAQ
8 Ras protein signal transduction GO:0007265 9.26 CDKN2A HRAS NRAS RREB1
9 regulation of melanocyte differentiation GO:0045634 9.16 GNA11 GNAQ
10 developmental pigmentation GO:0048066 8.92 GNA11 GNAQ KIT PMEL

Molecular functions related to Central Nervous System Melanocytic Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 obsolete signal transducer activity GO:0004871 9.35 GNA11 GNAQ PDCD1 S100A9 YARS
2 type 2A serotonin receptor binding GO:0031826 8.62 GNA11 GNAQ

Sources for Central Nervous System Melanocytic Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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