MCID: CNT042
MIFTS: 26

Central Nervous System Mesenchymal Non-Meningothelial Tumor

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Mesenchymal Non-Meningothelial Tumor

MalaCards integrated aliases for Central Nervous System Mesenchymal Non-Meningothelial Tumor:

Name: Central Nervous System Mesenchymal Non-Meningothelial Tumor 12 15
Non-Meningothelial Mesenchymal Tumor 12

Classifications:



External Ids:

Disease Ontology 12 DOID:502

Summaries for Central Nervous System Mesenchymal Non-Meningothelial Tumor

Disease Ontology : 12 A central nervous system cancer that is characterized by mesenchymal tumors within the CNS that develops from meninges, has material basis in abnormally proliferating cells derives from mesoderm.

MalaCards based summary : Central Nervous System Mesenchymal Non-Meningothelial Tumor, also known as non-meningothelial mesenchymal tumor, is related to hemophagocytic lymphohistiocytosis, familial, 1 and botryoid rhabdomyosarcoma. An important gene associated with Central Nervous System Mesenchymal Non-Meningothelial Tumor is PAX3 (Paired Box 3), and among its related pathways/superpathways are Neural Crest Differentiation and TGF-beta Signaling Pathways. Affiliated tissues include kidney, breast and skeletal muscle, and related phenotypes are mortality/aging and muscle

Related Diseases for Central Nervous System Mesenchymal Non-Meningothelial Tumor

Graphical network of the top 20 diseases related to Central Nervous System Mesenchymal Non-Meningothelial Tumor:



Diseases related to Central Nervous System Mesenchymal Non-Meningothelial Tumor

Symptoms & Phenotypes for Central Nervous System Mesenchymal Non-Meningothelial Tumor

MGI Mouse Phenotypes related to Central Nervous System Mesenchymal Non-Meningothelial Tumor:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 mortality/aging MP:0010768 9.91 FOXO1 MYF6 MYOD1 PAX3 PAX7 TSFM
2 muscle MP:0005369 9.8 FOXO1 MYF6 MYOD1 PAX3 PAX7
3 neoplasm MP:0002006 9.77 FOXO1 MYF6 MYOD1 PAX3 PAX7
4 embryo MP:0005380 9.76 FOXO1 MYF6 PAX3 PAX7
5 no phenotypic analysis MP:0003012 9.72 FOXO1 MYF6 MYOD1 PAX3 PAX7
6 normal MP:0002873 9.65 FOXO1 MYF6 MYOD1 PAX3 PAX7
7 respiratory system MP:0005388 9.46 MYF6 MYOD1 PAX3 PAX7
8 skeleton MP:0005390 9.35 FOXO1 MYF6 MYOD1 PAX3 PAX7
9 vision/eye MP:0005391 8.92 MYF6 PAX3 PAX7 TSFM

Drugs & Therapeutics for Central Nervous System Mesenchymal Non-Meningothelial Tumor

Search Clinical Trials , NIH Clinical Center for Central Nervous System Mesenchymal Non-Meningothelial Tumor

Genetic Tests for Central Nervous System Mesenchymal Non-Meningothelial Tumor

Anatomical Context for Central Nervous System Mesenchymal Non-Meningothelial Tumor

MalaCards organs/tissues related to Central Nervous System Mesenchymal Non-Meningothelial Tumor:

41
Kidney, Breast, Skeletal Muscle

Publications for Central Nervous System Mesenchymal Non-Meningothelial Tumor

Variations for Central Nervous System Mesenchymal Non-Meningothelial Tumor

Expression for Central Nervous System Mesenchymal Non-Meningothelial Tumor

Search GEO for disease gene expression data for Central Nervous System Mesenchymal Non-Meningothelial Tumor.

Pathways for Central Nervous System Mesenchymal Non-Meningothelial Tumor

Pathways related to Central Nervous System Mesenchymal Non-Meningothelial Tumor according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.47 PAX3 PAX7
2 11.42 FOXO1 MYOD1
3 11.3 MYF6 MYOD1
4 11.25 FOXO1 MYOD1
5
Show member pathways
11.09 MYF6 MYOD1
6 11.07 FOXO1 PAX3 PAX7
7 11 MYOD1 PAX3
8 10.75 FOXO1 MYOD1
9 10.51 MYOD1 PAX7

GO Terms for Central Nervous System Mesenchymal Non-Meningothelial Tumor

Cellular components related to Central Nervous System Mesenchymal Non-Meningothelial Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 nucleus GO:0005634 9.1 FOXO1 MYF6 MYOD1 PAX3 PAX7 TSFM

Biological processes related to Central Nervous System Mesenchymal Non-Meningothelial Tumor according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 multicellular organism development GO:0007275 9.83 MYF6 MYOD1 PAX3 PAX7
2 regulation of transcription, DNA-templated GO:0006355 9.8 FOXO1 MYF6 MYOD1 PAX3 PAX7
3 transcription by RNA polymerase II GO:0006366 9.73 MYF6 MYOD1 PAX3
4 positive regulation of transcription, DNA-templated GO:0045893 9.73 FOXO1 MYF6 MYOD1 PAX3
5 positive regulation of transcription by RNA polymerase II GO:0045944 9.72 FOXO1 MYF6 MYOD1 PAX3 PAX7
6 cellular response to starvation GO:0009267 9.55 FOXO1 MYOD1
7 skeletal muscle cell differentiation GO:0035914 9.54 MYF6 MYOD1
8 positive regulation of muscle cell differentiation GO:0051149 9.51 MYF6 MYOD1
9 skeletal muscle tissue regeneration GO:0043403 9.49 MYF6 PAX7
10 positive regulation of myoblast differentiation GO:0045663 9.48 MYF6 MYOD1
11 positive regulation of myoblast fusion GO:1901741 9.46 MYF6 MYOD1
12 positive regulation of skeletal muscle fiber development GO:0048743 9.37 MYF6 MYOD1
13 muscle cell fate commitment GO:0042693 9.26 MYF6 MYOD1
14 muscle tissue morphogenesis GO:0060415 9.16 MYF6 PAX7
15 skeletal muscle tissue development GO:0007519 9.13 MYF6 MYOD1 PAX7
16 muscle organ development GO:0007517 8.92 MYF6 MYOD1 PAX3 PAX7

Molecular functions related to Central Nervous System Mesenchymal Non-Meningothelial Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 DNA binding GO:0003677 9.65 FOXO1 MYF6 MYOD1 PAX3 PAX7
2 sequence-specific DNA binding GO:0043565 9.46 FOXO1 MYOD1 PAX3 PAX7
3 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding GO:0003705 9.37 MYF6 MYOD1
4 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000981 9.35 FOXO1 MYF6 MYOD1 PAX3 PAX7
5 E-box binding GO:0070888 9.32 MYF6 MYOD1
6 DNA-binding transcription factor activity GO:0003700 9.02 FOXO1 MYF6 MYOD1 PAX3 PAX7

Sources for Central Nervous System Mesenchymal Non-Meningothelial Tumor

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
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42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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