Central Nervous System Organ Benign Neoplasm disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Central Nervous System Organ Benign Neoplasm

MalaCards integrated aliases for Central Nervous System Organ Benign Neoplasm:

Name: Central Nervous System Organ Benign Neoplasm ¹² ¹⁵

Classifications:

MalaCards categories:
Global: Cancer diseases
Anatomical: Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹² DOID:0060090

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Summaries for Central Nervous System Organ Benign Neoplasm

MalaCards based summary : Central Nervous System Organ Benign Neoplasm is related to central nervous system germinoma and acidophil adenoma. An important gene associated with Central Nervous System Organ Benign Neoplasm is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Peptide hormone metabolism and Signaling pathways regulating pluripotency of stem cells. Related phenotypes are behavior/neurological and endocrine/exocrine gland

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Related Diseases for Central Nervous System Organ Benign Neoplasm

Diseases related to Central Nervous System Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)

#	Related Disease	Score	Top Affiliating Genes
1	central nervous system germinoma	10.9	AVP POMC
2	acidophil adenoma	10.9	IGF1 POMC
3	tuberculous epididymitis	10.9	AVP POMC
4	central nervous system germ cell tumor	10.8	AVP POMC
5	inappropriate adh syndrome	10.8	AVP POMC
6	adenohypophysitis	10.8	POMC PRL
7	secondary adrenal insufficiency	10.8	AVP IGF1
8	hypothalamic disease	10.8	POMC PRL
9	secondary hypertrophic osteoarthropathy	10.8	AVP POMC
10	chiasmal syndrome	10.8	POMC PRL
11	galactorrhea	10.8	IGF1 PRL
12	pituitary apoplexy	10.8	POMC PRL
13	pituitary carcinoma	10.7	POMC PRL
14	pseudohypoparathyroidism, type ia	10.7	IGF1 PRL
15	nelson syndrome	10.7	POMC PRL
16	pituitary adenoma 1, multiple types	10.7	IGF1 PRL
17	mixed type thymoma	10.7	AVP SYP
18	acth-secreting pituitary adenoma	10.7	POMC PRL
19	syndrome of inappropriate antidiuretic hormone	10.7	AVP POMC
20	fasting hypoglycemia	10.7	IGF1 POMC
21	olfactory nerve neoplasm	10.7	AVP SYP
22	mammographic density	10.6	IGF1 PRL
23	pulmonary sclerosing hemangioma	10.6	CTNNB1 SYP
24	pilomyxoid astrocytoma	10.6	KIAA1549 SYP
25	obstructive hydrocephalus	10.6	PRL SYP
26	functioning pituitary adenoma	10.6	POMC PRL
27	adult hepatocellular carcinoma	10.6	CTNNB1 TP53
28	female reproductive endometrioid cancer	10.5	CTNNB1 TP53
29	pancreas disease	10.5	AVP IGF1 POMC
30	diabetes insipidus, neurohypophyseal	10.5	AVP POMC PRL
31	premenstrual tension	10.5	AVP POMC PRL
32	pituitary infarct	10.5	IGF1 POMC PRL
33	sclerosing hemangioma	10.5	CTNNB1 SYP
34	empty sella syndrome	10.5	IGF1 POMC PRL
35	sheehan syndrome	10.5	IGF1 POMC PRL
36	hyperpituitarism	10.5	IGF1 POMC PRL
37	diabetes insipidus	10.5	AVP POMC PRL
38	endocrine organ benign neoplasm	10.5	IGF1 POMC PRL
39	thyroid gland disease	10.5	IGF1 POMC PRL
40	hyperprolactinemia	10.5	IGF1 POMC PRL
41	pituitary adenoma, prolactin-secreting	10.5	IGF1 POMC PRL
42	hyperandrogenism	10.5	IGF1 POMC PRL
43	cerebellar astrocytoma	10.5	KIAA1549 TP53
44	childhood oligodendroglioma	10.5	KIAA1549 SYP
45	acquired metabolic disease	10.5	IGF1 POMC PRL
46	primary pigmented nodular adrenocortical disease	10.5	CTNNB1 POMC SYP
47	acromegaly	10.5	IGF1 POMC PRL
48	anorexia nervosa	10.4	IGF1 POMC PRL
49	prolactin producing pituitary tumor	10.4	PRL TP53
50	pituitary hypoplasia	10.4	HESX1 PRL

Graphical network of the top 20 diseases related to Central Nervous System Organ Benign Neoplasm:

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Symptoms & Phenotypes for Central Nervous System Organ Benign Neoplasm

MGI Mouse Phenotypes related to Central Nervous System Organ Benign Neoplasm:

⁴⁶

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	behavior/neurological	MP:0005386	9.92	KIAA1549 POMC PRL PROP1 SYP AVP
2	endocrine/exocrine gland	MP:0005379	9.8	HESX1 IGF1 POMC PRL PROP1 TP53
3	nervous system	MP:0003631	9.61	IGF1 POMC PRL PROP1 SYP AVP
4	neoplasm	MP:0002006	9.55	IGF1 POMC PRL TP53 CTNNB1
5	normal	MP:0002873	9.17	IGF1 ARHGAP28 SYP AVP TP53 CTNNB1

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Drugs & Therapeutics for Central Nervous System Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Central Nervous System Organ Benign Neoplasm

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Genetic Tests for Central Nervous System Organ Benign Neoplasm

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Anatomical Context for Central Nervous System Organ Benign Neoplasm

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Publications for Central Nervous System Organ Benign Neoplasm

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Genes for Central Nervous System Organ Benign Neoplasm

Genes related to Central Nervous System Organ Benign Neoplasm (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	POMC	Proopiomelanocortin	Protein Coding	16.08	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
2	CTNNB1	Catenin Beta 1	Protein Coding	16.08	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
3	AVP	Arginine Vasopressin	Protein Coding	16.06	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
4	IGF1	Insulin Like Growth Factor 1	Protein Coding	15.84	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
5	PRL	Prolactin	Protein Coding	15.68	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
6	KIAA1549	KIAA1549	Protein Coding	15.64	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
7	SYP	Synaptophysin	Protein Coding	15.57	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
8	DNAH2	Dynein Axonemal Heavy Chain 2	Protein Coding	15.51	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
9	HESX1	HESX Homeobox 1	Protein Coding	15.48	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
10	TP53	Tumor Protein P53	Protein Coding	15.47	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
11	ARHGAP28	Rho GTPase Activating Protein 28	Protein Coding	15.45	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
12	DNAH7	Dynein Axonemal Heavy Chain 7	Protein Coding	15.36	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)
13	PROP1	PROP Paired-Like Homeobox 1	Protein Coding	15.28	DISEASES inferred ¹⁵ GeneCards inferred via : DISEASES inferred (show sections)

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Variations for Central Nervous System Organ Benign Neoplasm

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Expression for Central Nervous System Organ Benign Neoplasm

Search GEO for disease gene expression data for Central Nervous System Organ Benign Neoplasm.

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Pathways for Central Nervous System Organ Benign Neoplasm

Pathways related to Central Nervous System Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Peptide hormone metabolism ⁶⁶ Show member pathways Glycoprotein hormones ⁶⁶ Insulin processing ⁶⁶ Metabolism of Angiotensinogen to Angiotensins ⁶⁶ Peptide hormone biosynthesis ⁶⁶ Synthesis, secretion, and deacylation of Ghrelin ⁶⁶	11.69	CTNNB1 IGF1 POMC
2	Signaling pathways regulating pluripotency of stem cells ³⁷	11.47	CTNNB1 HESX1 IGF1
3	Glioblastoma Multiforme ⁶⁴	11.18	CTNNB1 IGF1 TP53
4	Glucocorticoid receptor regulatory network ¹	10.71	POMC PRL TP53

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GO Terms for Central Nervous System Organ Benign Neoplasm

Cellular components related to Central Nervous System Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	axonemal dynein complex	GO:0005858	8.62	DNAH2 DNAH7

Biological processes related to Central Nervous System Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of signaling receptor activity	GO:0010469	9.62	AVP IGF1 POMC PRL
2	positive regulation of gene expression	GO:0010628	9.56	AVP CTNNB1 IGF1 TP53
3	cell proliferation	GO:0008283	9.46	CTNNB1 IGF1 PRL TP53
4	ERK1 and ERK2 cascade	GO:0070371	9.43	AVP IGF1
5	regulation of multicellular organism growth	GO:0040014	9.4	IGF1 PRL
6	positive regulation of pri-miRNA transcription by RNA polymerase II	GO:1902895	9.37	PRL TP53
7	negative regulation of release of cytochrome c from mitochondria	GO:0090201	8.96	AVP IGF1
8	cilium-dependent cell motility	GO:0060285	8.62	DNAH2 DNAH7

Molecular functions related to Central Nervous System Organ Benign Neoplasm according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	chromatin binding	GO:0003682	9.46	CTNNB1 HESX1 PROP1 TP53
2	neuropeptide hormone activity	GO:0005184	9.4	AVP POMC
3	dynein light intermediate chain binding	GO:0051959	9.37	DNAH2 DNAH7
4	dynein intermediate chain binding	GO:0045505	9.32	DNAH2 DNAH7
5	dynein light chain binding	GO:0045503	9.26	DNAH2 DNAH7
6	ATP-dependent microtubule motor activity, minus-end-directed	GO:0008569	8.96	DNAH2 DNAH7
7	hormone activity	GO:0005179	8.92	AVP IGF1 POMC PRL

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