MCID: CNT043
MIFTS: 23

Central Nervous System Organ Benign Neoplasm

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Organ Benign Neoplasm

MalaCards integrated aliases for Central Nervous System Organ Benign Neoplasm:

Name: Central Nervous System Organ Benign Neoplasm 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0060090

Summaries for Central Nervous System Organ Benign Neoplasm

MalaCards based summary : Central Nervous System Organ Benign Neoplasm is related to central nervous system germinoma and acidophil adenoma. An important gene associated with Central Nervous System Organ Benign Neoplasm is POMC (Proopiomelanocortin), and among its related pathways/superpathways are Peptide hormone metabolism and Signaling pathways regulating pluripotency of stem cells. Related phenotypes are behavior/neurological and endocrine/exocrine gland

Related Diseases for Central Nervous System Organ Benign Neoplasm

Diseases related to Central Nervous System Organ Benign Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 central nervous system germinoma 10.9 AVP POMC
2 acidophil adenoma 10.9 IGF1 POMC
3 tuberculous epididymitis 10.9 AVP POMC
4 central nervous system germ cell tumor 10.8 AVP POMC
5 inappropriate adh syndrome 10.8 AVP POMC
6 adenohypophysitis 10.8 POMC PRL
7 secondary adrenal insufficiency 10.8 AVP IGF1
8 hypothalamic disease 10.8 POMC PRL
9 secondary hypertrophic osteoarthropathy 10.8 AVP POMC
10 chiasmal syndrome 10.8 POMC PRL
11 galactorrhea 10.8 IGF1 PRL
12 pituitary apoplexy 10.8 POMC PRL
13 pituitary carcinoma 10.7 POMC PRL
14 pseudohypoparathyroidism, type ia 10.7 IGF1 PRL
15 nelson syndrome 10.7 POMC PRL
16 pituitary adenoma 1, multiple types 10.7 IGF1 PRL
17 mixed type thymoma 10.7 AVP SYP
18 acth-secreting pituitary adenoma 10.7 POMC PRL
19 syndrome of inappropriate antidiuretic hormone 10.7 AVP POMC
20 fasting hypoglycemia 10.7 IGF1 POMC
21 olfactory nerve neoplasm 10.7 AVP SYP
22 mammographic density 10.6 IGF1 PRL
23 pulmonary sclerosing hemangioma 10.6 CTNNB1 SYP
24 pilomyxoid astrocytoma 10.6 KIAA1549 SYP
25 obstructive hydrocephalus 10.6 PRL SYP
26 functioning pituitary adenoma 10.6 POMC PRL
27 adult hepatocellular carcinoma 10.6 CTNNB1 TP53
28 female reproductive endometrioid cancer 10.5 CTNNB1 TP53
29 pancreas disease 10.5 AVP IGF1 POMC
30 diabetes insipidus, neurohypophyseal 10.5 AVP POMC PRL
31 premenstrual tension 10.5 AVP POMC PRL
32 pituitary infarct 10.5 IGF1 POMC PRL
33 sclerosing hemangioma 10.5 CTNNB1 SYP
34 empty sella syndrome 10.5 IGF1 POMC PRL
35 sheehan syndrome 10.5 IGF1 POMC PRL
36 hyperpituitarism 10.5 IGF1 POMC PRL
37 diabetes insipidus 10.5 AVP POMC PRL
38 endocrine organ benign neoplasm 10.5 IGF1 POMC PRL
39 thyroid gland disease 10.5 IGF1 POMC PRL
40 hyperprolactinemia 10.5 IGF1 POMC PRL
41 pituitary adenoma, prolactin-secreting 10.5 IGF1 POMC PRL
42 hyperandrogenism 10.5 IGF1 POMC PRL
43 cerebellar astrocytoma 10.5 KIAA1549 TP53
44 childhood oligodendroglioma 10.5 KIAA1549 SYP
45 acquired metabolic disease 10.5 IGF1 POMC PRL
46 primary pigmented nodular adrenocortical disease 10.5 CTNNB1 POMC SYP
47 acromegaly 10.5 IGF1 POMC PRL
48 anorexia nervosa 10.4 IGF1 POMC PRL
49 prolactin producing pituitary tumor 10.4 PRL TP53
50 pituitary hypoplasia 10.4 HESX1 PRL

Graphical network of the top 20 diseases related to Central Nervous System Organ Benign Neoplasm:



Diseases related to Central Nervous System Organ Benign Neoplasm

Symptoms & Phenotypes for Central Nervous System Organ Benign Neoplasm

MGI Mouse Phenotypes related to Central Nervous System Organ Benign Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.92 KIAA1549 POMC PRL PROP1 SYP AVP
2 endocrine/exocrine gland MP:0005379 9.8 HESX1 IGF1 POMC PRL PROP1 TP53
3 nervous system MP:0003631 9.61 IGF1 POMC PRL PROP1 SYP AVP
4 neoplasm MP:0002006 9.55 IGF1 POMC PRL TP53 CTNNB1
5 normal MP:0002873 9.17 IGF1 ARHGAP28 SYP AVP TP53 CTNNB1

Drugs & Therapeutics for Central Nervous System Organ Benign Neoplasm

Search Clinical Trials , NIH Clinical Center for Central Nervous System Organ Benign Neoplasm

Genetic Tests for Central Nervous System Organ Benign Neoplasm

Anatomical Context for Central Nervous System Organ Benign Neoplasm

Publications for Central Nervous System Organ Benign Neoplasm

Variations for Central Nervous System Organ Benign Neoplasm

Expression for Central Nervous System Organ Benign Neoplasm

Search GEO for disease gene expression data for Central Nervous System Organ Benign Neoplasm.

Pathways for Central Nervous System Organ Benign Neoplasm

Pathways related to Central Nervous System Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.69 CTNNB1 IGF1 POMC
2 11.47 CTNNB1 HESX1 IGF1
3 11.18 CTNNB1 IGF1 TP53
4 10.71 POMC PRL TP53

GO Terms for Central Nervous System Organ Benign Neoplasm

Cellular components related to Central Nervous System Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 axonemal dynein complex GO:0005858 8.62 DNAH2 DNAH7

Biological processes related to Central Nervous System Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.62 AVP IGF1 POMC PRL
2 positive regulation of gene expression GO:0010628 9.56 AVP CTNNB1 IGF1 TP53
3 cell proliferation GO:0008283 9.46 CTNNB1 IGF1 PRL TP53
4 ERK1 and ERK2 cascade GO:0070371 9.43 AVP IGF1
5 regulation of multicellular organism growth GO:0040014 9.4 IGF1 PRL
6 positive regulation of pri-miRNA transcription by RNA polymerase II GO:1902895 9.37 PRL TP53
7 negative regulation of release of cytochrome c from mitochondria GO:0090201 8.96 AVP IGF1
8 cilium-dependent cell motility GO:0060285 8.62 DNAH2 DNAH7

Molecular functions related to Central Nervous System Organ Benign Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin binding GO:0003682 9.46 CTNNB1 HESX1 PROP1 TP53
2 neuropeptide hormone activity GO:0005184 9.4 AVP POMC
3 dynein light intermediate chain binding GO:0051959 9.37 DNAH2 DNAH7
4 dynein intermediate chain binding GO:0045505 9.32 DNAH2 DNAH7
5 dynein light chain binding GO:0045503 9.26 DNAH2 DNAH7
6 ATP-dependent microtubule motor activity, minus-end-directed GO:0008569 8.96 DNAH2 DNAH7
7 hormone activity GO:0005179 8.92 AVP IGF1 POMC PRL

Sources for Central Nervous System Organ Benign Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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