Central Nervous System Origin Vertigo disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Central Nervous System Origin Vertigo

MalaCards integrated aliases for Central Nervous System Origin Vertigo:

Name: Central Nervous System Origin Vertigo ¹² ⁷³

Central Vestibular Vertigo ¹²

Vertigo of Central Origin ¹²

Vertigo ⁴⁴

Classifications:

MalaCards categories:
Anatomical: Ear diseases Neuronal diseases

See all MalaCards categories (disease lists)

ICD10: ³³

Diseases of the ear and mastoid process

Diseases of inner ear

Disorders of vestibular function

Vertigo of central origin

External Ids:

Disease Ontology ¹² DOID:2479

ICD10 ³³ H81.4 H81.49

ICD9CM ³⁵ 386.2

MeSH ⁴⁴ D014717

SNOMED-CT ⁶⁸ 20425006 38403006

UMLS ⁷³ C0155503

Sources

Summaries for Central Nervous System Origin Vertigo

Disease Ontology : ¹² A brain disease that is characterized by vertigo caused by hemorrhagic insult, ischemic insult or mass lesion of the cerebellum, the vestibular nuclei, and the brainstem, has symptom dizziness, has symptom nausea, has symptom vomiting and has symptom difficulty walking.

MalaCards based summary : Central Nervous System Origin Vertigo, also known as central vestibular vertigo, is related to vertigo, benign recurrent and peripheral vertigo, and has symptoms including vomiting, difficulty walking and nausea. An important gene associated with Central Nervous System Origin Vertigo is SCN2A (Sodium Voltage-Gated Channel Alpha Subunit 2). The drugs Propranolol and Norepinephrine have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and breast.

Wikipedia : ⁷⁶ Vertigo is a symptom where a person feels as if they or the objects around them are moving when they are... more...

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Related Diseases for Central Nervous System Origin Vertigo

Diseases related to Central Nervous System Origin Vertigo via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 193)

#	Related Disease	Score
1	vertigo, benign recurrent	12.6
2	peripheral vertigo	12.4
3	benign paroxysmal positional nystagmus	12.3
4	meniere disease	12.2
5	vertigo, benign recurrent, 2	12.1
6	viral labyrinthitis	11.8
7	geniculate herpes zoster	11.5
8	vestibular neuronitis	11.5
9	motion sickness	11.4
10	superior semicircular canal dehiscence	11.4
11	vestibular disease	11.4
12	episodic ataxia	11.3
13	myoclonus and ataxia	11.2
14	medulloblastoma	11.2
15	migraine with brainstem aura	11.2
16	episodic ataxia, type 3	11.2
17	fibromuscular dysplasia	11.0
18	deafness, autosomal dominant 6	11.0
19	cogan syndrome	11.0
20	autosomal dominant partial epilepsy with auditory features	11.0
21	arachnoid cysts	11.0
22	migraine, familial hemiplegic, 1	10.9
23	otitis media	10.9
24	sneddon syndrome	10.9
25	basal ganglia calcification, idiopathic, 1	10.9
26	deafness, autosomal dominant 9	10.9
27	migraine, familial hemiplegic, 2	10.9
28	kanzaki disease	10.9
29	migraine, familial hemiplegic, 3	10.9
30	migraine with or without aura 13	10.9
31	episodic ataxia, type 5	10.9
32	patulous eustachian tube	10.9
33	lateral medullary syndrome	10.9
34	brain stem infarction	10.9
35	paraneoplastic neurologic disorders	10.9
36	subacute cerebellar degeneration	10.9
37	intracranial cysts	10.9
38	paraneoplastic syndromes	10.9
39	pathologic nystagmus	10.6
40	ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus	10.6
41	sensorineural hearing loss	10.4
42	sudden sensorineural hearing loss	10.4
43	acoustic neuroma	10.3
44	neuritis	10.3
45	osteoporosis	10.2
46	anxiety	10.1
47	otosclerosis	10.1
48	spondylosis	10.1
49	vertebrobasilar insufficiency	10.1
50	neurilemmoma	10.1

Comorbidity relations with Central Nervous System Origin Vertigo via Phenotypic Disease Network (PDN):

Hypertension, Essential

Ischemic Heart Disease

Graphical network of the top 20 diseases related to Central Nervous System Origin Vertigo:

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Symptoms & Phenotypes for Central Nervous System Origin Vertigo

Symptoms:

¹²

• vomiting
• difficulty walking

• nausea
• dizziness

UMLS symptoms related to Central Nervous System Origin Vertigo:

vertigo

Sources

Drugs & Therapeutics for Central Nervous System Origin Vertigo

Drugs for Central Nervous System Origin Vertigo (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Propranolol

Approved, Investigational

Phase 4

525-66-6

4946

Synonyms:

(+-)-Propranolol

(1)-1-(Isopropylamino)-3-(naphthyloxy)propan-2-ol

(R)-(+)-propranolol

(S)-(-)-PROPRANOLOL

1-((1-Methylethyl)amino)-3-(1-naphthalenyloxy)-2-propanol

1-(1-Naphthyloxy)-2-hydroxy-3-(isopropylamino)propane

1-(Isopropylamino)-3-(1-naphthoxy)-propan-2-ol

1-(Isopropylamino)-3-(1-naphthyloxy)-2-propanol

1-(isopropylamino)-3-(1-naphthyloxy)propan-2-ol

1-(isopropylamino)-3-(1-Naphthyloxy)propan-2-ol

1-(naphthalen-1-yloxy)-3-(propan-2-ylamino)propan-2-ol

1-[(1-methylethyl)amino]-3-(naphthalen-1-yloxy)propan-2-ol

13013-17-7

1-Isopropylamino-3-(1-naphthyloxy)-2-propanol

1-naphthalen-1-yloxy-3-(propan-2-ylamino)propan-2-ol

2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)- (9CI)

2-Propanol, 1-((1-methylethyl)amino)-3-(1-naphthalenyloxy)-, (+-)- (9CI)

3-(naphthalen-1-yloxy)-1-(propan-2-ylamino)propan-2-ol

4199-09-1

4199-10-4

525-66-6

AB00053537

AC1L1JA4

AC1Q1QBV

AC1Q1QC0

AKOS000588816

Anaprilin

Anapriline

Angilol

Apsolol

Avlocardyl

AY 64043

AY-20694

Bedranol

Beprane

Berkolol

Beta Neg

Betachron

Betadren

Betalong

Beta-Neg

beta-Propranolol

Beta-Propranolol

Beta-Tablinen

Beta-Timelets

Bio-0732

Bio1_000367

Bio1_000856

Bio1_001345

BPBio1_001040

b-Propranolol

BRD-A10070317-003-06-9

BSPBio_000944

BSPBio_002682

C07407

C16H21NO2

Cardinol

Caridolol

CBDivE_006180

CCRIS 3082

CHEBI:8499

CHEMBL27

CID4946

cMAP_000071

Corpendol

D,L-Propranolol

D08443

DB00571

Deralin

Dexpropranolol

DivK1c_000023

Dl-Propranolol Hydrochloride

DL-Propranolol hydrochloride

Dociton

Duranol

Efektolol

EINECS 208-378-0

EINECS 235-867-6

Elbrol

etalong

Etalong

Euprovasin

Frekven

Herzbase

HMS2090L21

Hydrochloride, propranolol

ICI 45520

IDI1_000023

Ikopal

Inderal

Inderal hydrochloride

Inderal La

Inderalici

Inderex

Inderide

INDERIDE-40/25

INDERIDE-80/25

Inderol

Indobloc

Innopran XL

InnoPranXL

Intermigran

KBio1_000023

KBio2_002515

KBio2_005083

KBio2_007651

KBio3_001766

KBio3_001902

KBio3_002993

KBioGR_001347

KBioGR_001684

KBioGR_002515

KBioSS_002523

Kemi

Kemi S

L000679

Lopac0_000896

LS-122410

LS-184129

Migrastat

MolPort-001-794-623

Naprilin

NCGC00015798-07

NCGC00024690-02

NCGC00024690-03

NINDS_000023

NSC91523

Obsidan

Obzidan

Oposim

Oprea1_304193

PDSP1_000767

PDSP1_001607

PDSP1_001608

PDSP2_000755

PDSP2_001591

PDSP2_001592

Pranolol

Prano-Puren

Prestwick0_000952

Prestwick1_000952

Prestwick2_000952

Prestwick3_000952

Pronovan

Propanalol

Propanix

Propanolol

Propanolol [INN-Spanish]

Prophylux

Propranalol

propranolol

Propranolol

Propranolol (INN)

Propranolol (TN)

Propranolol [INN:BAN]

Propranolol Hcl

Propranolol Hcl Intensol

Propranolol hydrochloride

Propranolol Hydrochloride

propranololo

Propranololo

Propranololo [DCIT]

Propranololum

Propranololum [INN-Latin]

Propranur

Proprasylyt

Pylapron

R,S-Propranolol Hydrochloride

Racemic propranolol

Rapynogen

Reducor

Reducor line

Reducor Line

Rexigen

Sagittol

Sawatal

Servanolol

Sloprolol

SPBio_001361

SPBio_001658

SPBio_003093

Spectrum2_001301

Spectrum2_001699

Spectrum3_000883

Spectrum3_001071

Spectrum4_000974

Spectrum4_001222

Spectrum5_000751

STK735510

Sumial

Tesnol

UNII-9Y8NXQ24VQ

β-propranolol

β-Propranolol

2

Norepinephrine

Approved

Phase 4

51-41-2

439260

Synonyms:

(-)-(R)-Norepinephrine

(-)-alpha-(Aminomethyl)protocatechuyl alcohol

(-)-Arterenol

(-)-Arterenol free base

(-)-Noradrenaline

(-)-NORADRENALINE

(-)-Norepinephrine

(R)-(-)-Norepinephrine

(R)-4-(2-amino-1-Hydroxyethyl)-1,2-benzenediol

(R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol

(R)-Noradrenaline

(R)-Norepinephrine

1,2-Benzenediol, 4-(2-amino-1-hydroxyethyl)-, (R)- (9CI)

4-(2-amino-1-Hydroxyethyl)-1,2-benzenediol

4-[(1R)-2-amino-1-Hydroxyethyl]-1,2-benzenediol

4-[(1R)-2-Amino-1-hydroxyethyl]-1,2-benzenediol

4-[(1R)-2-amino-1-hydroxyethyl]benzene-1,2-diol

4899-05-2

51-40-1 (l-tartrate (1:1))

51-41-2

66197-73-7

A7257_SIGMA

Abbott brand OF levophed bitartrate

AC1L96ZT

Adrenor

Aktamin

ALBB-006229

Arterenol

Aventis brand OF norepinephrine hydrochloride

Bitartrate, levophed

Bitartrate, noradrenaline

Bitartrate, norepinephrine

bmse000404

BRN 4231961

BSPBio_002079

C00547

CHEBI:18357

CHEMBL1437

CID439260

D-(-)-Noradrenaline

D00076

D53D5E3A-2360-4CA9-8031-6C2CD4062FD5

DB00368

DivK1c_000230

EINECS 200-096-6

HMS1920B08

HMS2089E18

HMS2091J08

HMS500L12

Hydrochloride, norepinephrine

IDI1_000230

KBio1_000230

KBio2_001489

KBio2_004057

KBio2_006625

KBio3_001579

KBioGR_000635

KBioSS_001489

l-1-(3,4-Dihydroxyphenyl)-2-aminoethanol

l-2-Amino-1-(3,4-dihydroxyphenyl)ethanol

L-2-amino-1-(3,4-Dihydroxyphenyl)ethanol

L-3,4-dihydroxyphenylethanolamine

L-3,4-Dihydroxyphenylethanolamine

L-alpha-(aminomethyl)-3,4-dihydroxybenzyl alcohol

L-alpha-(Aminomethyl)-3,4-dihydroxybenzyl alcohol

L-arterenol

L-Arterenol

Levarterenol

Levarterenolo

Levarterenolo [DCIT]

Levoarterenol

Levonor

Levonoradrenaline

Levonorepinephrine

Levophed

Levophed bitartrate

L-noradrenaline

L-Noradrenaline

L-Norepinephrine

L-NOREPINEPHRINE

LS-42676

LT03330026

LT4

NCGC00159406-02

NCGC00159406-03

NCGC00159406-04

NCGC00159406-05

NCGC00159406-06

NCGC00159406-07

NCGC00159406-09

nchembio.284-comp2

nchembio.64-comp2

nchembio705-1

NINDS_000230

Nor adrenalin

Nor adrenalin (TN)

Noradrenalin

Noradrenalina

Noradrenalina [Italian]

noradrenaline

Noradrenaline

Nor-adrenaline

Noradrenaline (JP15)

Noradrenaline bitartrate

Noradrénaline tartrate renaudin

Noradrenalinum

Norartrinal

Noreinefrina

Noreinefrina [INN-Spanish]

norepinefrina

Norepinefrina

Norepinephrin D-tartrate (1:1)

norepinephrine

Norepinephrine

Norepinephrine (INN)

Norepinephrine [INN:JAN]

Norepinephrine bitartrate

Norepinephrine D-tartrate (1:1)

Norepinephrine hydrochloride

Norepinephrine hydrochloride, (+)-isomer

Norepinephrine hydrochloride, (+,-)-isomer

Norepinephrine l-Tartrate (1:1)

Norepinephrine L-tartrate (1:1)

Norepinephrine L-tartrate (1:1), (+,-)-isomer

Norepinephrine L-tartrate (1:1), monohydrate

Norepinephrine L-tartrate (1:1), monohydrate, (+)-isomer

Norepinephrine L-tartrate (1:2)

Norepinephrine L-tartrate, (+)-isomer

Norepinephrine Noradrenalin

Norepinephrine, (+)-isomer

Norepinephrine, (+,-)-isomer

norepinephrinum

Norepinephrinum

Norepinephrinum [INN-Latin]

Norepirenamine

Nor-epirenan

PDSP1_001111

PDSP2_001095

Renaudin brand OF norepinephrine bitartrate

Renaudin, noradrénaline tartrate

SGCUT00123

SPBio_001048

Spectrum_001009

SPECTRUM1500436

Spectrum2_001064

Spectrum3_000520

Spectrum4_000078

Spectrum5_001068

STK503776

Sympathin e

Sympathin E

Tartrate renaudin, noradrénaline

to_000024

UNII-X4W3ENH1CV

3

Neurotransmitter Uptake Inhibitors

Phase 4

4

Serotonin and Noradrenaline Reuptake Inhibitors

Phase 4

5

Psychotropic Drugs

Phase 4

6

Antidepressive Agents

Phase 4

7

Antidepressive Agents, Second-Generation

Phase 4

8

Antihypertensive Agents

Phase 4

9

Venlafaxine Hydrochloride

Phase 4

10

Anti-Arrhythmia Agents

Phase 4

11

Adrenergic beta-Antagonists

Phase 4

12

Serotonin Uptake Inhibitors

Phase 4

13

Neurotransmitter Agents

Phase 4

14

Adrenergic Antagonists

Phase 4

15

Vasodilator Agents

Phase 4

16

Adrenergic Agents

Phase 4

17

Serotonin

Investigational, Nutraceutical

Phase 4

50-67-9

5202

Synonyms:

3-(2-Aminoethyl)-1H-indol-5-ol

3-(2-Aminoethyl)indol-5-ol

3-(b-Aminoethyl)-5-hydroxyindole

5 Hydroxytryptamine

5-HT

5-HTA

5-Hydroxy-3-(b-aminoethyl)indole

5-Hydroxyltryptamine

5-Hydroxytriptamine

5-Hydroxytryptamine

5-Hydroxy-tryptamine

Antemovis

DS Substance

Enteramin

Enteramine

Hippophaine

Hydroxytryptamine

Serotonine

sérotonine

thrombocytin

Thrombocytin

thrombotonin

Thrombotonin

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Comparison of Propranolol and Venlafaxine in Treatment of Vestibular Migraine	Completed	NCT02350985	Phase 4	Propranolol;Venlafaxine
2	Accuracy of a Diagnostic Algorithm for the Differential Diagnosis of Vertigo in the ED: the STANDING.	Completed	NCT02782962

Search NIH Clinical Center for Central Nervous System Origin Vertigo

Cochrane evidence based reviews: vertigo

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Genetic Tests for Central Nervous System Origin Vertigo

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Anatomical Context for Central Nervous System Origin Vertigo

MalaCards organs/tissues related to Central Nervous System Origin Vertigo:

⁴¹

Brain, Cerebellum, Breast, Spinal Cord, Thyroid, T Cells, Myeloid

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Publications for Central Nervous System Origin Vertigo

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Genes for Central Nervous System Origin Vertigo

Genes related to Central Nervous System Origin Vertigo (1 elite genes):

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubmedIds
1	SCN2A	Sodium Voltage-Gated Channel Alpha Subunit 2	Protein Coding	400	Pathogenic/Likely pathogenic ⁶

Sources

Variations for Central Nervous System Origin Vertigo

ClinVar genetic disease variations for Central Nervous System Origin Vertigo:

⁶ (show all 12)

#	Gene	Variation	Type	Significance	SNP ID	Assembly	Location
1	SLC25A4	NM_001151.3(SLC25A4): c.368C> A (p.Ala123Asp)	single nucleotide variant	Conflicting interpretations of pathogenicity	rs121912683	GRCh37	Chromosome 4, 186066174: 186066174
2	SLC25A4	NM_001151.3(SLC25A4): c.368C> A (p.Ala123Asp)	single nucleotide variant	Conflicting interpretations of pathogenicity	rs121912683	GRCh38	Chromosome 4, 185145020: 185145020
3	SCN2A	NM_021007.2(SCN2A): c.2960G> T (p.Ser987Ile)	single nucleotide variant	Pathogenic/Likely pathogenic	rs796053124	GRCh37	Chromosome 2, 166210742: 166210742
4	SCN2A	NM_021007.2(SCN2A): c.2960G> T (p.Ser987Ile)	single nucleotide variant	Pathogenic/Likely pathogenic	rs796053124	GRCh38	Chromosome 2, 165354232: 165354232
5	CLCN1	NM_000083.2(CLCN1): c.568_569delGGinsTC (p.Gly190Ser)	indel	Conflicting interpretations of pathogenicity	rs797045032	GRCh37	Chromosome 7, 143018813: 143018814
6	CLCN1	NM_000083.2(CLCN1): c.568_569delGGinsTC (p.Gly190Ser)	indel	Conflicting interpretations of pathogenicity	rs797045032	GRCh38	Chromosome 7, 143321720: 143321721
7	TNC	NM_002160.3(TNC): c.890A> G (p.Asn297Ser)	single nucleotide variant	Uncertain significance		GRCh37	Chromosome 9, 117849120: 117849120
8	TNC	NM_002160.3(TNC): c.890A> G (p.Asn297Ser)	single nucleotide variant	Uncertain significance		GRCh38	Chromosome 9, 115086841: 115086841
9	DYNC1H1	NM_001376.4(DYNC1H1): c.13298A> C (p.Asp4433Ala)	single nucleotide variant	Uncertain significance		GRCh38	Chromosome 14, 102048595: 102048595
10	DYNC1H1	NM_001376.4(DYNC1H1): c.13298A> C (p.Asp4433Ala)	single nucleotide variant	Uncertain significance		GRCh37	Chromosome 14, 102514932: 102514932
11	MT-ND6	NC_012920.1: m.14477A> G	single nucleotide variant	Uncertain significance		GRCh37	Chromosome MT, 14477: 14477
12	MT-ND6	NC_012920.1: m.14477A> G	single nucleotide variant	Uncertain significance		GRCh38	Chromosome MT, 14477: 14477

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Expression for Central Nervous System Origin Vertigo

Search GEO for disease gene expression data for Central Nervous System Origin Vertigo.

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Pathways for Central Nervous System Origin Vertigo

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GO Terms for Central Nervous System Origin Vertigo

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Sources for Central Nervous System Origin Vertigo

¹ BioSystems

² BitterDB

³ CDC

⁴ Cell Signaling Technology

⁵ ClinicalTrials

⁶ ClinVar

⁷ CNVD

⁸ Cochrane Library

⁹ Cosmic

¹⁰ dbSNP

¹¹ DGIdb

¹² Disease Ontology

¹³ diseasecard

¹⁴ DiseaseEnhancer

¹⁵ DISEASES

¹⁶ DrugBank

¹⁷ ExPASy

¹⁸ FDA Approved Drugs

¹⁹ FMA

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ Genetics Home Reference

²⁶ GenomeRNAi

²⁷ GEO DataSets

²⁸ GO

²⁹ GTR

³⁰ HGMD

³¹ HMDB

³² HPO

³³ ICD10

³⁴ ICD10 via Orphanet

³⁵ ICD9CM

³⁶ IUPHAR

³⁷ KEGG

³⁸ LifeMap

³⁹ LncRNADisease

⁴⁰ LOVD

⁴¹ MalaCards

⁴² MedGen

⁴³ MedlinePlus

⁴⁴ MeSH

⁴⁵ MESH via Orphanet

⁴⁶ MGI

⁴⁷ miR2Disease

⁴⁸ NCBI Bookshelf

⁴⁹ NCI

⁵⁰ NCIt

⁵¹ NDF-RT

⁵² NIH Clinical Center

⁵³ NIH Rare Diseases

⁵⁴ NINDS

⁵⁵ Novoseek

⁵⁶ Novus Biologicals

⁵⁷ OMIM

⁵⁸ OMIM via Orphanet

⁵⁹ Orphanet

⁶⁰ PathCards

⁶¹ PharmGKB

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ SNOMED-CT via Orphanet

⁷¹ TGDB

⁷² Tocris

⁷³ UMLS

⁷⁴ UMLS via Orphanet

⁷⁵ UniProtKB/Swiss-Prot

⁷⁶ Wikipedia