MCID: CNT017
MIFTS: 28

Central Nervous System Origin Vertigo

Categories: Ear diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Origin Vertigo

MalaCards integrated aliases for Central Nervous System Origin Vertigo:

Name: Central Nervous System Origin Vertigo 12 74
Central Vestibular Vertigo 12
Vertigo of Central Origin 12
Vertigo 45

Classifications:



External Ids:

Disease Ontology 12 DOID:2479
ICD9CM 36 386.2
MeSH 45 D014717
SNOMED-CT 69 20425006 38403006
ICD10 34 H81.4 H81.49
UMLS 74 C0155503

Summaries for Central Nervous System Origin Vertigo

Disease Ontology : 12 A brain disease that is characterized by vertigo caused by hemorrhagic insult, ischemic insult or mass lesion of the cerebellum, the vestibular nuclei, and the brainstem, has symptom dizziness, has symptom nausea, has symptom vomiting and has symptom difficulty walking.

MalaCards based summary : Central Nervous System Origin Vertigo, also known as central vestibular vertigo, is related to vertigo, benign recurrent and peripheral vertigo, and has symptoms including vomiting, difficulty walking and nausea. An important gene associated with Central Nervous System Origin Vertigo is SCN2A (Sodium Voltage-Gated Channel Alpha Subunit 2). The drugs Norepinephrine and Propranolol have been mentioned in the context of this disorder. Affiliated tissues include brain, cerebellum and lung.

Wikipedia : 77 Vertigo is a symptom where a person feels as if they or the objects around them are moving when they are... more...

Related Diseases for Central Nervous System Origin Vertigo

Diseases related to Central Nervous System Origin Vertigo via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 231)
# Related Disease Score Top Affiliating Genes
1 vertigo, benign recurrent 12.6
2 peripheral vertigo 12.4
3 benign paroxysmal positional nystagmus 12.3
4 meniere disease 12.2
5 vertigo, benign recurrent, 2 12.2
6 viral labyrinthitis 12.0
7 motion sickness 11.8
8 episodic ataxia, type 3 11.7
9 geniculate herpes zoster 11.5
10 vestibular neuronitis 11.5
11 superior semicircular canal dehiscence 11.4
12 vestibular disease 11.4
13 cogan syndrome 11.4
14 acoustic neuroma 11.3
15 otosclerosis 11.3
16 episodic ataxia 11.3
17 myoclonus and ataxia 11.3
18 medulloblastoma 11.3
19 otitis media 11.3
20 deafness, autosomal dominant 9 11.3
21 migraine with brainstem aura 11.3
22 fibromuscular dysplasia 11.1
23 deafness, autosomal dominant 6 11.1
24 episodic ataxia, type 5 11.1
25 arachnoid cysts 11.1
26 autosomal dominant partial epilepsy with auditory features 11.1
27 migraine, familial hemiplegic, 1 10.9
28 sneddon syndrome 10.9
29 basal ganglia calcification, idiopathic, 1 10.9
30 migraine, familial hemiplegic, 2 10.9
31 episodic ataxia, type 4 10.9
32 kanzaki disease 10.9
33 migraine, familial hemiplegic, 3 10.9
34 migraine with or without aura 13 10.9
35 patulous eustachian tube 10.9
36 lateral medullary syndrome 10.9
37 brain stem infarction 10.9
38 paraneoplastic neurologic disorders 10.9
39 subacute cerebellar degeneration 10.9
40 intracranial cysts 10.9
41 paraneoplastic syndromes 10.9
42 pathologic nystagmus 10.7
43 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.7
44 sensorineural hearing loss 10.5
45 sudden sensorineural hearing loss 10.4
46 neuritis 10.4
47 migraine with or without aura 1 10.3
48 neurilemmoma 10.3
49 osteoporosis 10.3
50 anxiety 10.2

Comorbidity relations with Central Nervous System Origin Vertigo via Phenotypic Disease Network (PDN):


Hypertension, Essential Ischemic Heart Disease

Graphical network of the top 20 diseases related to Central Nervous System Origin Vertigo:



Diseases related to Central Nervous System Origin Vertigo

Symptoms & Phenotypes for Central Nervous System Origin Vertigo

Symptoms:

12
  • vomiting
  • difficulty walking
  • nausea
  • dizziness

UMLS symptoms related to Central Nervous System Origin Vertigo:


vertigo

Drugs & Therapeutics for Central Nervous System Origin Vertigo

Drugs for Central Nervous System Origin Vertigo (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Norepinephrine Approved Phase 4 51-41-2 439260
2
Propranolol Approved, Investigational Phase 4 525-66-6 4946
3 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
4 Neurotransmitter Agents Phase 4
5 Serotonin Uptake Inhibitors Phase 4
6 Adrenergic Antagonists Phase 4
7 Anti-Arrhythmia Agents Phase 4
8 Adrenergic Agents Phase 4
9 Antidepressive Agents, Second-Generation Phase 4
10 Antihypertensive Agents Phase 4
11 Psychotropic Drugs Phase 4
12 Antidepressive Agents Phase 4
13 Vasodilator Agents Phase 4
14 Venlafaxine Hydrochloride Phase 4
15 Neurotransmitter Uptake Inhibitors Phase 4
16 Adrenergic beta-Antagonists Phase 4
17
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison of Propranolol and Venlafaxine in Treatment of Vestibular Migraine Completed NCT02350985 Phase 4 Propranolol;Venlafaxine
2 Accuracy of a Diagnostic Algorithm for the Differential Diagnosis of Vertigo in the ED: the STANDING. Completed NCT02782962

Search NIH Clinical Center for Central Nervous System Origin Vertigo

Cochrane evidence based reviews: vertigo

Genetic Tests for Central Nervous System Origin Vertigo

Anatomical Context for Central Nervous System Origin Vertigo

MalaCards organs/tissues related to Central Nervous System Origin Vertigo:

42
Brain, Cerebellum, Lung, Bone, Thyroid, T Cells, Eye

Publications for Central Nervous System Origin Vertigo

Variations for Central Nervous System Origin Vertigo

ClinVar genetic disease variations for Central Nervous System Origin Vertigo:

6 (show all 12)
# Gene Variation Type Significance SNP ID Assembly Location
1 SLC25A4 NM_001151.3(SLC25A4): c.368C> A (p.Ala123Asp) single nucleotide variant Conflicting interpretations of pathogenicity rs121912683 GRCh37 Chromosome 4, 186066174: 186066174
2 SLC25A4 NM_001151.3(SLC25A4): c.368C> A (p.Ala123Asp) single nucleotide variant Conflicting interpretations of pathogenicity rs121912683 GRCh38 Chromosome 4, 185145020: 185145020
3 SCN2A NM_021007.2(SCN2A): c.2960G> T (p.Ser987Ile) single nucleotide variant Pathogenic/Likely pathogenic rs796053124 GRCh37 Chromosome 2, 166210742: 166210742
4 SCN2A NM_021007.2(SCN2A): c.2960G> T (p.Ser987Ile) single nucleotide variant Pathogenic/Likely pathogenic rs796053124 GRCh38 Chromosome 2, 165354232: 165354232
5 CLCN1 NM_000083.2(CLCN1): c.568_569delGGinsTC (p.Gly190Ser) indel Conflicting interpretations of pathogenicity rs797045032 GRCh37 Chromosome 7, 143018813: 143018814
6 CLCN1 NM_000083.2(CLCN1): c.568_569delGGinsTC (p.Gly190Ser) indel Conflicting interpretations of pathogenicity rs797045032 GRCh38 Chromosome 7, 143321720: 143321721
7 TNC NM_002160.3(TNC): c.890A> G (p.Asn297Ser) single nucleotide variant Uncertain significance rs1554717312 GRCh37 Chromosome 9, 117849120: 117849120
8 TNC NM_002160.3(TNC): c.890A> G (p.Asn297Ser) single nucleotide variant Uncertain significance rs1554717312 GRCh38 Chromosome 9, 115086841: 115086841
9 DYNC1H1 NM_001376.4(DYNC1H1): c.13298A> C (p.Asp4433Ala) single nucleotide variant Uncertain significance rs1555412625 GRCh38 Chromosome 14, 102048595: 102048595
10 DYNC1H1 NM_001376.4(DYNC1H1): c.13298A> C (p.Asp4433Ala) single nucleotide variant Uncertain significance rs1555412625 GRCh37 Chromosome 14, 102514932: 102514932
11 MT-ND6 NC_012920.1: m.14477A> G single nucleotide variant Uncertain significance rs1556424448 GRCh37 Chromosome MT, 14477: 14477
12 MT-ND6 NC_012920.1: m.14477A> G single nucleotide variant Uncertain significance rs1556424448 GRCh38 Chromosome MT, 14477: 14477

Expression for Central Nervous System Origin Vertigo

Search GEO for disease gene expression data for Central Nervous System Origin Vertigo.

Pathways for Central Nervous System Origin Vertigo

GO Terms for Central Nervous System Origin Vertigo

Sources for Central Nervous System Origin Vertigo

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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