MCID: CNT017
MIFTS: 22

Central Nervous System Origin Vertigo

Categories: Ear diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Origin Vertigo

MalaCards integrated aliases for Central Nervous System Origin Vertigo:

Name: Central Nervous System Origin Vertigo 12 73
Central Vestibular Vertigo 12
Vertigo of Central Origin 12
Vertigo 44

Classifications:



External Ids:

Disease Ontology 12 DOID:2479
ICD10 33 H81.4 H81.49
ICD9CM 35 386.2
MeSH 44 D014717
UMLS 73 C0155503

Summaries for Central Nervous System Origin Vertigo

MalaCards based summary : Central Nervous System Origin Vertigo, also known as central vestibular vertigo, is related to vertigo, benign recurrent and peripheral vertigo, and has symptoms including vertigo An important gene associated with Central Nervous System Origin Vertigo is SCN2A (Sodium Voltage-Gated Channel Alpha Subunit 2). The drugs Norepinephrine and Propranolol have been mentioned in the context of this disorder.

Wikipedia : 76 Vertigo is a symptom where a person feels as if they or the objects around them are moving when they are... more...

Related Diseases for Central Nervous System Origin Vertigo

Diseases related to Central Nervous System Origin Vertigo via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 131)
# Related Disease Score Top Affiliating Genes
1 vertigo, benign recurrent 12.4
2 peripheral vertigo 12.2
3 benign paroxysmal positional nystagmus 12.1
4 meniere disease 12.0
5 vertigo, benign recurrent, 2 12.0
6 viral labyrinthitis 11.6
7 vestibular neuronitis 11.3
8 motion sickness 11.2
9 vestibular disease 11.2
10 episodic ataxia 11.1
11 medulloblastoma 11.1
12 geniculate herpes zoster 11.1
13 episodic ataxia, type 3 11.0
14 fibromuscular dysplasia 10.9
15 deafness, autosomal dominant 6 10.9
16 cogan syndrome 10.9
17 superior semicircular canal dehiscence 10.9
18 autosomal dominant partial epilepsy with auditory features 10.9
19 arachnoid cysts 10.9
20 migraine, familial hemiplegic, 1 10.8
21 sneddon syndrome 10.8
22 basal ganglia calcification, idiopathic, 1 10.8
23 deafness, autosomal dominant 9 10.8
24 migraine, familial hemiplegic, 2 10.8
25 kanzaki disease 10.8
26 migraine, familial hemiplegic, 3 10.8
27 migraine with or without aura 13 10.8
28 episodic ataxia, type 5 10.8
29 patulous eustachian tube 10.8
30 migraine with brainstem aura 10.8
31 paraneoplastic neurologic disorders 10.8
32 subacute cerebellar degeneration 10.8
33 intracranial cysts 10.8
34 paraneoplastic syndromes 10.8
35 ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus 10.3
36 sensorineural hearing loss 10.2
37 neuritis 10.1
38 cervicitis 10.1
39 sudden sensorineural hearing loss 10.1
40 vertebrobasilar insufficiency 10.0
41 spondylosis 10.0
42 neuronitis 10.0
43 otosclerosis 9.9
44 labyrinthitis 9.9
45 perilymphatic fistula 9.9
46 whiplash 9.9
47 spinocerebellar ataxia 6 9.8
48 deafness, autosomal recessive 4, with enlarged vestibular aqueduct 9.8
49 subclavian steal syndrome 9.8
50 autosomal dominant cerebellar ataxia 9.8

Comorbidity relations with Central Nervous System Origin Vertigo via Phenotypic Disease Network (PDN):


Hypertension, Essential Ischemic Heart Disease

Graphical network of the top 20 diseases related to Central Nervous System Origin Vertigo:



Diseases related to Central Nervous System Origin Vertigo

Symptoms & Phenotypes for Central Nervous System Origin Vertigo

UMLS symptoms related to Central Nervous System Origin Vertigo:


vertigo

Drugs & Therapeutics for Central Nervous System Origin Vertigo

Drugs for Central Nervous System Origin Vertigo (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 17)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Norepinephrine Approved Phase 4 51-41-2 439260
2
Propranolol Approved, Investigational Phase 4 525-66-6 4946
3 Adrenergic Agents Phase 4
4 Adrenergic Antagonists Phase 4
5 Adrenergic beta-Antagonists Phase 4
6 Anti-Arrhythmia Agents Phase 4
7 Antidepressive Agents Phase 4
8 Antidepressive Agents, Second-Generation Phase 4
9 Antihypertensive Agents Phase 4
10 Neurotransmitter Agents Phase 4
11 Neurotransmitter Uptake Inhibitors Phase 4
12 Psychotropic Drugs Phase 4
13 Serotonin and Noradrenaline Reuptake Inhibitors Phase 4
14 Serotonin Uptake Inhibitors Phase 4
15 Vasodilator Agents Phase 4
16 Venlafaxine Hydrochloride Phase 4
17
Serotonin Investigational, Nutraceutical Phase 4 50-67-9 5202

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Comparison of Propranolol and Venlafaxine in Treatment of Vestibular Migraine Completed NCT02350985 Phase 4 Propranolol;Venlafaxine
2 Accuracy of a Diagnostic Algorithm for the Differential Diagnosis of Vertigo in the ED: the STANDING. Completed NCT02782962

Search NIH Clinical Center for Central Nervous System Origin Vertigo

Cochrane evidence based reviews: vertigo

Genetic Tests for Central Nervous System Origin Vertigo

Anatomical Context for Central Nervous System Origin Vertigo

Publications for Central Nervous System Origin Vertigo

Variations for Central Nervous System Origin Vertigo

ClinVar genetic disease variations for Central Nervous System Origin Vertigo:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 SCN2A NM_021007.2(SCN2A): c.2960G> T (p.Ser987Ile) single nucleotide variant Pathogenic/Likely pathogenic rs796053124 GRCh37 Chromosome 2, 166210742: 166210742
2 SCN2A NM_021007.2(SCN2A): c.2960G> T (p.Ser987Ile) single nucleotide variant Pathogenic/Likely pathogenic rs796053124 GRCh38 Chromosome 2, 165354232: 165354232
3 CLCN1 NM_000083.2(CLCN1): c.568_569delGGinsTC (p.Gly190Ser) indel Conflicting interpretations of pathogenicity rs797045032 GRCh37 Chromosome 7, 143018813: 143018814
4 CLCN1 NM_000083.2(CLCN1): c.568_569delGGinsTC (p.Gly190Ser) indel Conflicting interpretations of pathogenicity rs797045032 GRCh38 Chromosome 7, 143321720: 143321721
5 TNC NM_002160.3(TNC): c.890A> G (p.Asn297Ser) single nucleotide variant Uncertain significance GRCh37 Chromosome 9, 117849120: 117849120
6 TNC NM_002160.3(TNC): c.890A> G (p.Asn297Ser) single nucleotide variant Uncertain significance GRCh38 Chromosome 9, 115086841: 115086841
7 DYNC1H1 NM_001376.4(DYNC1H1): c.13298A> C (p.Asp4433Ala) single nucleotide variant Uncertain significance GRCh38 Chromosome 14, 102048595: 102048595
8 DYNC1H1 NM_001376.4(DYNC1H1): c.13298A> C (p.Asp4433Ala) single nucleotide variant Uncertain significance GRCh37 Chromosome 14, 102514932: 102514932
9 MT-ND6 NC_012920.1: m.14477A> G single nucleotide variant Uncertain significance GRCh37 Chromosome MT, 14477: 14477
10 MT-ND6 NC_012920.1: m.14477A> G single nucleotide variant Uncertain significance GRCh38 Chromosome MT, 14477: 14477

Expression for Central Nervous System Origin Vertigo

Search GEO for disease gene expression data for Central Nervous System Origin Vertigo.

Pathways for Central Nervous System Origin Vertigo

GO Terms for Central Nervous System Origin Vertigo

Sources for Central Nervous System Origin Vertigo

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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