CPNET
MCID: CNT044
MIFTS: 27

Central Nervous System Primitive Neuroectodermal Neoplasm (CPNET)

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Primitive Neuroectodermal Neoplasm

MalaCards integrated aliases for Central Nervous System Primitive Neuroectodermal Neoplasm:

Name: Central Nervous System Primitive Neuroectodermal Neoplasm 12 15
Cpnet 72

Classifications:



External Ids:

Disease Ontology 12 DOID:0060103
UMLS 72 C3887678

Summaries for Central Nervous System Primitive Neuroectodermal Neoplasm

Disease Ontology : 12 A central nervous system cancer of children and young adults that develops from neural crest cells located in cerebrum, has material basis in abnormally proliferating cells derives from neuroectoderm.

MalaCards based summary : Central Nervous System Primitive Neuroectodermal Neoplasm, also known as cpnet, is related to childhood central nervous system primitive neuroectodermal neoplasm and adult central nervous system primitive neuroectodermal neoplasm. An important gene associated with Central Nervous System Primitive Neuroectodermal Neoplasm is LIN28A (Lin-28 Homolog A), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include brain, ovary and uterus, and related phenotype is nervous system.

Related Diseases for Central Nervous System Primitive Neuroectodermal Neoplasm

Diseases in the Central Nervous System Primitive Neuroectodermal Neoplasm family:

Adult Central Nervous System Primitive Neuroectodermal Neoplasm

Diseases related to Central Nervous System Primitive Neuroectodermal Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 160)
# Related Disease Score Top Affiliating Genes
1 childhood central nervous system primitive neuroectodermal neoplasm 12.8
2 adult central nervous system primitive neuroectodermal neoplasm 12.7
3 male reproductive organ benign neoplasm 10.5 SYP DICER1
4 carotid body cancer 10.5 SYP ENO2
5 urinary bladder small cell neuroendocrine carcinoma 10.5 SYP ENO2
6 malignant sertoli cell tumor 10.5 SYP ENO2
7 auditory system cancer 10.5 SYP ENO2
8 small cell carcinoma 10.5 SYP ENO2
9 sinonasal undifferentiated carcinoma 10.5 SYP ENO2
10 small cell carcinoma of the bladder 10.5 SYP ENO2
11 extrahepatic bile duct adenocarcinoma 10.5 SYP ENO2
12 cutaneous ganglioneuroma 10.5 SYP ENO2
13 pancreatic somatostatinoma 10.5 SYP ENO2
14 middle ear adenoma 10.5 SYP ENO2
15 pulmonary blastoma 10.5 SYP DICER1
16 orbital cancer 10.5 SYP ENO2
17 sensory organ benign neoplasm 10.5 SYP ENO2
18 atypical follicular adenoma 10.5 SYP ENO2
19 gallbladder small cell carcinoma 10.5 SYP ENO2
20 pulmonary large cell neuroendocrine carcinoma 10.5 SYP ENO2
21 large cell neuroendocrine carcinoma 10.5 SYP ENO2
22 endometrial small cell carcinoma 10.5 SYP ENO2
23 cauda equina neoplasm 10.5 SYP ENO2
24 malignant teratoma 10.5 SYP ENO2
25 extraosseous chondrosarcoma 10.5 SYP ENO2
26 olfactory nerve neoplasm 10.5 SYP ENO2
27 nodular ganglioneuroblastoma 10.5 SYP ENO2
28 ganglioneuroblastoma 10.5 SYP ENO2
29 autonomic nervous system benign neoplasm 10.4 SYP ENO2
30 atypical choroid plexus papilloma 10.4 SYP DICER1
31 desmoplastic small round cell tumor 10.4 SYP ENO2
32 gastric small cell carcinoma 10.4 SYP ENO2
33 cervical clear cell adenocarcinoma 10.4 SYP ENO2
34 angiomyoma 10.4 SYP ENO2
35 rhabdoid cancer 10.4 SYP ENO2
36 mucinous ovarian cystadenoma 10.4 SYP ENO2
37 respiratory system benign neoplasm 10.4 SYP ENO2
38 carcinoid tumors, intestinal 10.4 SYP ENO2
39 meningeal melanomatosis 10.4 SYP ENO2
40 gastric squamous cell carcinoma 10.4 SYP ENO2
41 bone benign neoplasm 10.4 SYP ENO2
42 extraskeletal ewing sarcoma 10.4 SYP ENO2
43 intraocular retinoblastoma 10.4 SYP ENO2
44 glomus tumor 10.4 SYP ENO2
45 connective tissue benign neoplasm 10.4 SYP ENO2
46 carcinoid syndrome 10.4 SYP ENO2
47 extraventricular neurocytoma 10.4 SYP GFAP
48 desmoplastic infantile ganglioglioma 10.4 SYP GFAP
49 lung combined type small cell carcinoma 10.4 SYP GFAP
50 cervix small cell carcinoma 10.4 SYP ENO2

Graphical network of the top 20 diseases related to Central Nervous System Primitive Neuroectodermal Neoplasm:



Diseases related to Central Nervous System Primitive Neuroectodermal Neoplasm

Symptoms & Phenotypes for Central Nervous System Primitive Neuroectodermal Neoplasm

MGI Mouse Phenotypes related to Central Nervous System Primitive Neuroectodermal Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.17 CADPS DICER1 ENO2 GFAP LIN28A MAP2

Drugs & Therapeutics for Central Nervous System Primitive Neuroectodermal Neoplasm

Search Clinical Trials , NIH Clinical Center for Central Nervous System Primitive Neuroectodermal Neoplasm

Genetic Tests for Central Nervous System Primitive Neuroectodermal Neoplasm

Anatomical Context for Central Nervous System Primitive Neuroectodermal Neoplasm

MalaCards organs/tissues related to Central Nervous System Primitive Neuroectodermal Neoplasm:

41
Brain, Ovary, Uterus

The Foundational Model of Anatomy Ontology organs/tissues related to Central Nervous System Primitive Neuroectodermal Neoplasm:

19
Cerebrum

Publications for Central Nervous System Primitive Neuroectodermal Neoplasm

Articles related to Central Nervous System Primitive Neuroectodermal Neoplasm:

(show all 25)
# Title Authors PMID Year
1
ZBTB16: A new biomarker for primitive neuroectodermal tumor element / Ewing sarcoma. 38
31326195 2019
2
Ewing-Like Sarcoma: A Case of a Primary Cutaneous Primitive Neuroectodermal Tumor With Atypical Immunohistochemistry and Lack of Fusion Oncogene Detection. 38
30067549 2018
3
[Survival and prognostic factors analysis of primitive neuroectodermal tumor]. 38
30139033 2018
4
Cystic pancreatic neuroendocrine tumor. Pancreatic endocrine or neuroendocrine tumor. Endoscopic ultrasonography. 38
29313698 2018
5
Clinical management of a unique case of PNET of the uterus during pregnancy, and review of the literature. 38
29480840 2018
6
Primary intracranial dural-based Ewing sarcoma/peripheral primitive neuroectodermal tumor mimicking a meningioma: A rare tumor with review of literature. 38
28761507 2017
7
Comparison of Primary Spinal Central and Peripheral Primitive Neuroectodermal Tumors in Clinical and Imaging Characteristics and Long-Term Outcome. 38
26748171 2016
8
Cervicomedullary intramedullary peripheral primitive neuroectodermal tumor with intratumoral bleed: Report of one case and review of literature. 38
27217659 2016
9
The imaging findings of infratentorial primitive neuroectodermal tumour: A case report. 38
26493270 2015
10
Novel treatment of a central type, primitive neuroectodermal tumor of the ovary with postoperative pediatric medulloblastoma chemotherapy regimen: A case report and review of the literature. 38
26425724 2015
11
Kinetics of porphyrin fluorescence accumulation in pediatric brain tumor cells incubated in 5-aminolevulinic acid. 38
24777761 2014
12
Central primary primitive neuroectodermal tumor (cPNET) arising from an ovarian mature cystic teratoma in pregnancy: A case report and review of medical literature. 38
24371678 2013
13
Extending the phenotypes associated with DICER1 mutations. 38
21882293 2011
14
Primary peripheral PNET/Ewing's sarcoma arising in the meninges, confirmed by the presence of the rare translocation t(21;22) (q22;q12). 38
21284749 2011
15
The evaluation of CD99 immunoreactivity and EWS/FLI1 translocation by fluorescence in situ hybridization in central PNETs and Ewing's sarcoma family of tumors. 38
21267687 2011
16
KIT expression and methylation in medulloblastoma and PNET cell lines and tumors. 38
20853134 2011
17
CD133+ cells from medulloblastoma and PNET cell lines are more resistant to cyclopamine inhibition of the sonic hedgehog signaling pathway than CD133- cells. 38
20480407 2010
18
Primary Ewing sarcoma of the brain: a case report and literature review. 38
17525681 2007
19
Temozolomide in resistant or relapsed pediatric solid tumors. 38
16047361 2006
20
Primitive neuroectodermal tumours (PNETs) located in the spinal canal; the relevance of classification as central or peripheral PNET : case report of a primary spinal PNET occurrence with a critical literature review. 38
16292490 2006
21
[A case of peripheral-type primitive neuroectodermal tumor arising in the dura mater at the frontal base]. 38
15112448 2004
22
Features of proliferation and in vitro drug resistance in central primitive neuro-ectodermal tumours. 38
12060344 2002
23
Alternative EWS-FLI1 fusion gene and MIC2 expression in peripheral and central primitive neuroectodermal tumors. 38
11304041 2001
24
High expression of somatostatin receptor subtype 2 (sst2) in medulloblastoma: implications for diagnosis and therapy. 38
10231868 1999
25
Vasoactive intestinal peptide (VIP) and VIP receptors: gene expression and growth modulation in medulloblastoma and other central primitive neuroectodermal tumors of childhood. 38
10188714 1999

Variations for Central Nervous System Primitive Neuroectodermal Neoplasm

Expression for Central Nervous System Primitive Neuroectodermal Neoplasm

Search GEO for disease gene expression data for Central Nervous System Primitive Neuroectodermal Neoplasm.

Pathways for Central Nervous System Primitive Neuroectodermal Neoplasm

Pathways related to Central Nervous System Primitive Neuroectodermal Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 SYP MAP2 GFAP ENO2
2 10.82 SYP NES MAP2 GFAP

GO Terms for Central Nervous System Primitive Neuroectodermal Neoplasm

Cellular components related to Central Nervous System Primitive Neuroectodermal Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament cytoskeleton GO:0045111 8.62 NES GFAP

Biological processes related to Central Nervous System Primitive Neuroectodermal Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gene silencing by RNA GO:0031047 9.26 LIN28A DICER1
2 cellular response to organic substance GO:0071310 9.16 SYP MAP2
3 miRNA metabolic process GO:0010586 8.96 LIN28A DICER1
4 pre-miRNA processing GO:0031054 8.62 LIN28A DICER1

Molecular functions related to Central Nervous System Primitive Neuroectodermal Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.62 MAP2 GFAP

Sources for Central Nervous System Primitive Neuroectodermal Neoplasm

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