CPNET
MCID: CNT044
MIFTS: 28

Central Nervous System Primitive Neuroectodermal Neoplasm (CPNET)

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Primitive Neuroectodermal Neoplasm

MalaCards integrated aliases for Central Nervous System Primitive Neuroectodermal Neoplasm:

Name: Central Nervous System Primitive Neuroectodermal Neoplasm 12 15
Cpnet 73

Classifications:



External Ids:

Disease Ontology 12 DOID:0060103
UMLS 73 C3887678

Summaries for Central Nervous System Primitive Neuroectodermal Neoplasm

Disease Ontology : 12 A central nervous system cancer of children and young adults that develops from neural crest cells located in cerebrum, has material basis in abnormally proliferating cells derives from neuroectoderm.

MalaCards based summary : Central Nervous System Primitive Neuroectodermal Neoplasm, also known as cpnet, is related to adult central nervous system primitive neuroectodermal neoplasm and childhood central nervous system primitive neuroectodermal neoplasm. An important gene associated with Central Nervous System Primitive Neuroectodermal Neoplasm is LIN28A (Lin-28 Homolog A), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include lung, brain and bone, and related phenotypes are behavior/neurological and nervous system

Related Diseases for Central Nervous System Primitive Neuroectodermal Neoplasm

Diseases in the Central Nervous System Primitive Neuroectodermal Neoplasm family:

Adult Central Nervous System Primitive Neuroectodermal Neoplasm

Diseases related to Central Nervous System Primitive Neuroectodermal Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 189)
# Related Disease Score Top Affiliating Genes
1 adult central nervous system primitive neuroectodermal neoplasm 12.6
2 childhood central nervous system primitive neuroectodermal neoplasm 12.6
3 sex cord-gonadal stromal tumor 10.2 DICER1 SYP
4 alveolar soft part sarcoma 10.2 ENO2 SYP
5 chondrosarcoma, extraskeletal myxoid 10.2 ENO2 SYP
6 malignant pheochromocytoma 10.2 ENO2 SYP
7 adrenal rest tumor 10.2 ENO2 SYP
8 olfactory neuroblastoma 10.2 ENO2 SYP
9 adrenal carcinoma 10.2 ENO2 SYP
10 large cell carcinoma 10.2 ENO2 SYP
11 pineal parenchymal tumor of intermediate differentiation 10.2 ENO2 SYP
12 mixed ductal-endocrine carcinoma 10.2 ENO2 SYP
13 male reproductive organ benign neoplasm 10.2 DICER1 SYP
14 carotid body cancer 10.2 ENO2 SYP
15 cerebellopontine angle tumor 10.2 GFAP SYP
16 malignant sertoli cell tumor 10.2 ENO2 SYP
17 urinary bladder small cell neuroendocrine carcinoma 10.2 ENO2 SYP
18 auditory system cancer 10.2 ENO2 SYP
19 sinonasal undifferentiated carcinoma 10.2 ENO2 SYP
20 gallbladder small cell carcinoma 10.2 ENO2 SYP
21 pancreatic somatostatinoma 10.2 ENO2 SYP
22 cutaneous ganglioneuroma 10.2 ENO2 SYP
23 extrahepatic bile duct adenocarcinoma 10.2 ENO2 SYP
24 small cell carcinoma of the bladder 10.2 ENO2 SYP
25 papillary tumor of the pineal region 10.1 ENO2 SYP
26 sensory organ benign neoplasm 10.1 ENO2 SYP
27 orbital cancer 10.1 ENO2 SYP
28 middle ear adenoma 10.1 ENO2 SYP
29 pulmonary large cell neuroendocrine carcinoma 10.1 ENO2 SYP
30 large cell neuroendocrine carcinoma 10.1 ENO2 SYP
31 ileum cancer 10.1 ENO2 GFAP
32 cauda equina neoplasm 10.1 ENO2 SYP
33 endometrial small cell carcinoma 10.1 ENO2 SYP
34 scrapie 10.1 ENO2 GFAP
35 extraosseous chondrosarcoma 10.1 ENO2 SYP
36 olfactory nerve neoplasm 10.1 ENO2 SYP
37 desmoplastic infantile ganglioglioma 10.1 GFAP SYP
38 extraventricular neurocytoma 10.1 GFAP SYP
39 autonomic nervous system benign neoplasm 10.1 ENO2 SYP
40 nodular ganglioneuroblastoma 10.1 ENO2 SYP
41 lung combined type small cell carcinoma 10.1 GFAP SYP
42 ganglioneuroblastoma 10.1 ENO2 SYP
43 angiomyoma 10.1 ENO2 SYP
44 rhabdoid tumor predisposition syndrome 1 10.1 SYP TP53
45 cell type benign neoplasm 10.1 SYP TP53
46 cervical clear cell adenocarcinoma 10.1 ENO2 SYP
47 neuroma 10.1 ENO2 GFAP
48 gastric small cell carcinoma 10.1 ENO2 SYP
49 thymus cancer 10.1 SYP TP53
50 chordoid meningioma 10.1 GFAP SYP

Graphical network of the top 20 diseases related to Central Nervous System Primitive Neuroectodermal Neoplasm:



Diseases related to Central Nervous System Primitive Neuroectodermal Neoplasm

Symptoms & Phenotypes for Central Nervous System Primitive Neuroectodermal Neoplasm

MGI Mouse Phenotypes related to Central Nervous System Primitive Neuroectodermal Neoplasm:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.63 DICER1 ENO2 GFAP LIN28A SYP TP53
2 nervous system MP:0003631 9.43 DICER1 ENO2 GFAP LIN28A SYP TP53
3 normal MP:0002873 9.02 DICER1 GFAP LIN28A SYP TP53

Drugs & Therapeutics for Central Nervous System Primitive Neuroectodermal Neoplasm

Search Clinical Trials , NIH Clinical Center for Central Nervous System Primitive Neuroectodermal Neoplasm

Genetic Tests for Central Nervous System Primitive Neuroectodermal Neoplasm

Anatomical Context for Central Nervous System Primitive Neuroectodermal Neoplasm

MalaCards organs/tissues related to Central Nervous System Primitive Neuroectodermal Neoplasm:

41
Lung, Brain, Bone, Ovary, Cervix, Thymus, Pineal

The Foundational Model of Anatomy Ontology organs/tissues related to Central Nervous System Primitive Neuroectodermal Neoplasm:

19
Cerebrum

Publications for Central Nervous System Primitive Neuroectodermal Neoplasm

Variations for Central Nervous System Primitive Neuroectodermal Neoplasm

Expression for Central Nervous System Primitive Neuroectodermal Neoplasm

Search GEO for disease gene expression data for Central Nervous System Primitive Neuroectodermal Neoplasm.

Pathways for Central Nervous System Primitive Neuroectodermal Neoplasm

Pathways related to Central Nervous System Primitive Neuroectodermal Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.67 ENO2 GFAP SYP
2 10.7 GFAP NES SYP

GO Terms for Central Nervous System Primitive Neuroectodermal Neoplasm

Cellular components related to Central Nervous System Primitive Neuroectodermal Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament cytoskeleton GO:0045111 8.62 GFAP NES

Biological processes related to Central Nervous System Primitive Neuroectodermal Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gene silencing by RNA GO:0031047 9.26 DICER1 LIN28A
2 miRNA metabolic process GO:0010586 9.16 DICER1 LIN28A
3 pre-miRNA processing GO:0031054 8.96 DICER1 LIN28A
4 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 8.62 LIN28A TP53

Molecular functions related to Central Nervous System Primitive Neuroectodermal Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein self-association GO:0043621 8.62 SYP TP53

Sources for Central Nervous System Primitive Neuroectodermal Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
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31 HMDB
32 HPO
33 ICD10
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62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
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73 UMLS
74 UMLS via Orphanet
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