MCID: CNT044
MIFTS: 28

Central Nervous System Primitive Neuroectodermal Neoplasm

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Primitive Neuroectodermal Neoplasm

MalaCards integrated aliases for Central Nervous System Primitive Neuroectodermal Neoplasm:

Name: Central Nervous System Primitive Neuroectodermal Neoplasm 12 15
Cpnet 74

Classifications:



External Ids:

Disease Ontology 12 DOID:0060103
UMLS 74 C3887678

Summaries for Central Nervous System Primitive Neuroectodermal Neoplasm

Disease Ontology : 12 A central nervous system cancer of children and young adults that develops from neural crest cells located in cerebrum, has material basis in abnormally proliferating cells derives from neuroectoderm.

MalaCards based summary : Central Nervous System Primitive Neuroectodermal Neoplasm, also known as cpnet, is related to adult central nervous system primitive neuroectodermal neoplasm and childhood central nervous system primitive neuroectodermal neoplasm. An important gene associated with Central Nervous System Primitive Neuroectodermal Neoplasm is LIN28A (Lin-28 Homolog A), and among its related pathways/superpathways are Neuroscience and Neural Stem Cell Differentiation Pathways and Lineage-specific Markers. Affiliated tissues include brain, pineal and lung, and related phenotypes are behavior/neurological and nervous system

Related Diseases for Central Nervous System Primitive Neuroectodermal Neoplasm

Diseases in the Central Nervous System Primitive Neuroectodermal Neoplasm family:

Adult Central Nervous System Primitive Neuroectodermal Neoplasm

Diseases related to Central Nervous System Primitive Neuroectodermal Neoplasm via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 163)
# Related Disease Score Top Affiliating Genes
1 adult central nervous system primitive neuroectodermal neoplasm 12.6
2 childhood central nervous system primitive neuroectodermal neoplasm 12.6
3 alveolar soft part sarcoma 10.3 ENO2 SYP
4 paraganglioma 10.3 ENO2 SYP
5 male reproductive organ benign neoplasm 10.3 DICER1 SYP
6 adrenal carcinoma 10.3 ENO2 SYP
7 carotid body cancer 10.3 ENO2 SYP
8 malignant sertoli cell tumor 10.3 ENO2 SYP
9 urinary bladder small cell neuroendocrine carcinoma 10.3 ENO2 SYP
10 pulmonary blastoma 10.3 DICER1 SYP
11 small cell carcinoma 10.3 ENO2 SYP
12 auditory system cancer 10.2 ENO2 SYP
13 sinonasal undifferentiated carcinoma 10.2 ENO2 SYP
14 pancreatic somatostatinoma 10.2 ENO2 SYP
15 cutaneous ganglioneuroma 10.2 ENO2 SYP
16 extrahepatic bile duct adenocarcinoma 10.2 ENO2 SYP
17 small cell carcinoma of the bladder 10.2 ENO2 SYP
18 sensory organ benign neoplasm 10.2 ENO2 SYP
19 orbital cancer 10.2 ENO2 SYP
20 middle ear adenoma 10.2 ENO2 SYP
21 pulmonary large cell neuroendocrine carcinoma 10.2 ENO2 SYP
22 large cell neuroendocrine carcinoma 10.2 ENO2 SYP
23 gallbladder small cell carcinoma 10.2 ENO2 SYP
24 atypical follicular adenoma 10.2 ENO2 SYP
25 cauda equina neoplasm 10.2 ENO2 SYP
26 atypical choroid plexus papilloma 10.2 DICER1 SYP
27 endometrial small cell carcinoma 10.2 ENO2 SYP
28 extraosseous chondrosarcoma 10.2 ENO2 SYP
29 malignant teratoma 10.2 ENO2 SYP
30 olfactory nerve neoplasm 10.2 ENO2 SYP
31 autonomic nervous system benign neoplasm 10.2 ENO2 SYP
32 nodular ganglioneuroblastoma 10.2 ENO2 SYP
33 ganglioneuroblastoma 10.2 ENO2 SYP
34 rhabdoid cancer 10.2 ENO2 SYP
35 angiomyoma 10.2 ENO2 SYP
36 cervical clear cell adenocarcinoma 10.2 ENO2 SYP
37 gastric small cell carcinoma 10.2 ENO2 SYP
38 desmoplastic small round cell tumor 10.2 ENO2 SYP
39 carcinoid tumors, intestinal 10.2 ENO2 SYP
40 respiratory system benign neoplasm 10.2 ENO2 SYP
41 mucinous ovarian cystadenoma 10.2 ENO2 SYP
42 bone benign neoplasm 10.2 ENO2 SYP
43 gastric squamous cell carcinoma 10.2 ENO2 SYP
44 meningeal melanomatosis 10.2 ENO2 SYP
45 extraskeletal ewing sarcoma 10.2 ENO2 SYP
46 rosette-forming glioneuronal tumor 10.2 MAP2 SYP
47 connective tissue benign neoplasm 10.2 ENO2 SYP
48 glomus tumor 10.2 ENO2 SYP
49 intraocular retinoblastoma 10.2 ENO2 SYP
50 carcinoid syndrome 10.2 ENO2 SYP

Graphical network of the top 20 diseases related to Central Nervous System Primitive Neuroectodermal Neoplasm:



Diseases related to Central Nervous System Primitive Neuroectodermal Neoplasm

Symptoms & Phenotypes for Central Nervous System Primitive Neuroectodermal Neoplasm

MGI Mouse Phenotypes related to Central Nervous System Primitive Neuroectodermal Neoplasm:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.43 DICER1 ENO2 GFAP LIN28A MAP2 SYP
2 nervous system MP:0003631 9.1 DICER1 ENO2 GFAP LIN28A MAP2 SYP

Drugs & Therapeutics for Central Nervous System Primitive Neuroectodermal Neoplasm

Search Clinical Trials , NIH Clinical Center for Central Nervous System Primitive Neuroectodermal Neoplasm

Genetic Tests for Central Nervous System Primitive Neuroectodermal Neoplasm

Anatomical Context for Central Nervous System Primitive Neuroectodermal Neoplasm

MalaCards organs/tissues related to Central Nervous System Primitive Neuroectodermal Neoplasm:

42
Brain, Pineal, Lung, Ovary, Cervix, Bone, Cerebellum

The Foundational Model of Anatomy Ontology organs/tissues related to Central Nervous System Primitive Neuroectodermal Neoplasm:

20
Cerebrum

Publications for Central Nervous System Primitive Neuroectodermal Neoplasm

Articles related to Central Nervous System Primitive Neuroectodermal Neoplasm:

# Title Authors Year
1
Central primary primitive neuroectodermal tumor (cPNET) arising from an ovarian mature cystic teratoma in pregnancy: A case report and review of medical literature. ( 24371678 )
2013

Variations for Central Nervous System Primitive Neuroectodermal Neoplasm

Expression for Central Nervous System Primitive Neuroectodermal Neoplasm

Search GEO for disease gene expression data for Central Nervous System Primitive Neuroectodermal Neoplasm.

Pathways for Central Nervous System Primitive Neuroectodermal Neoplasm

Pathways related to Central Nervous System Primitive Neuroectodermal Neoplasm according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.79 ENO2 GFAP MAP2 SYP
2 10.82 GFAP MAP2 NES SYP

GO Terms for Central Nervous System Primitive Neuroectodermal Neoplasm

Cellular components related to Central Nervous System Primitive Neuroectodermal Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 intermediate filament cytoskeleton GO:0045111 8.62 GFAP NES

Biological processes related to Central Nervous System Primitive Neuroectodermal Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 gene silencing by RNA GO:0031047 9.26 DICER1 LIN28A
2 cellular response to organic substance GO:0071310 9.16 MAP2 SYP
3 miRNA metabolic process GO:0010586 8.96 DICER1 LIN28A
4 pre-miRNA processing GO:0031054 8.62 DICER1 LIN28A

Molecular functions related to Central Nervous System Primitive Neuroectodermal Neoplasm according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 structural molecule activity GO:0005198 8.8 GFAP MAP2 NES

Sources for Central Nervous System Primitive Neuroectodermal Neoplasm

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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