MCID: CNT021
MIFTS: 20

Central Nervous System Rhabdomyosarcoma

Categories: Cancer diseases, Muscle diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Rhabdomyosarcoma

MalaCards integrated aliases for Central Nervous System Rhabdomyosarcoma:

Name: Central Nervous System Rhabdomyosarcoma 12 15 71
Rhabdomyosarcoma of the Cns 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4048
NCIt 49 C5464
UMLS 71 C1332891

Summaries for Central Nervous System Rhabdomyosarcoma

MalaCards based summary : Central Nervous System Rhabdomyosarcoma, also known as rhabdomyosarcoma of the cns, is related to orbit embryonal rhabdomyosarcoma and embryonal rhabdomyosarcoma. An important gene associated with Central Nervous System Rhabdomyosarcoma is SGTA (Small Glutamine Rich Tetratricopeptide Repeat Containing Alpha), and among its related pathways/superpathways are Peroxisome and Cytosine methylation. Related phenotype is neoplasm.

Related Diseases for Central Nervous System Rhabdomyosarcoma

Diseases related to Central Nervous System Rhabdomyosarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 orbit embryonal rhabdomyosarcoma 10.1 PAX3 FOXO1
2 embryonal rhabdomyosarcoma 10.1 PAX3 FOXO1
3 prostate embryonal rhabdomyosarcoma 10.1 PAX3 FOXO1
4 parameningeal embryonal rhabdomyosarcoma 10.1 PAX3 FOXO1
5 breast rhabdomyosarcoma 10.0 PAX3 FOXO1
6 pleomorphic rhabdomyosarcoma 10.0 PAX3 FOXO1
7 oligoastrocytoma 10.0 MGMT IDH2
8 rhabdomyosarcoma 10.0
9 anaplastic oligodendroglioma 10.0 MGMT IDH2
10 synovium cancer 9.9 PAX3 FOXO1
11 skeletal muscle cancer 9.9 PAX3 FOXO1
12 muscle cancer 9.9 PAX3 FOXO1
13 rhabdomyosarcoma 2 9.8 PAX3 FOXO1
14 enchondroma 9.8 IDH2 IDH1
15 breast duct papilloma 9.8 IDH2 IDH1
16 cytogenetically normal acute myeloid leukemia 9.8 IDH2 IDH1
17 intracranial chondrosarcoma 9.8 IDH2 IDH1
18 periosteal chondrosarcoma 9.8 IDH2 IDH1
19 breast hemangioma 9.8 IDH2 IDH1
20 juxtacortical chondroma 9.8 IDH2 IDH1
21 adult oligodendroglioma 9.8 IDH2 IDH1
22 cerebellar astrocytoma 9.8 IDH2 IDH1
23 clear cell chondrosarcoma 9.8 IDH2 IDH1
24 undifferentiated pleomorphic sarcoma 9.8 IDH2 IDH1
25 cerebellum cancer 9.8 IDH2 IDH1
26 chondroblastic osteosarcoma 9.8 IDH2 IDH1
27 adult astrocytic tumour 9.8 IDH2 IDH1
28 intraductal breast neoplasm 9.8 IDH2 IDH1
29 intraductal papilloma 9.7 IDH2 IDH1
30 multiple enchondromatosis, maffucci type 9.7 IDH2 IDH1
31 spindle cell hemangioma 9.7 IDH2 IDH1
32 frontal lobe neoplasm 9.7 MGMT IDH1
33 spinal cord astrocytoma 9.7 MGMT IDH1
34 d-2-hydroxyglutaric aciduria 1 9.7 IDH2 IDH1
35 2-hydroxyglutaric aciduria 9.7 IDH2 IDH1
36 l-2-hydroxyglutaric aciduria 9.7 IDH2 IDH1
37 thoracic benign neoplasm 9.7 IDH2 IDH1
38 breast benign neoplasm 9.7 IDH2 IDH1
39 glioblastoma classical subtype 9.7 MGMT IDH1
40 enchondromatosis, multiple, ollier type 9.7 IDH2 IDH1
41 malignant ependymoma 9.7 MGMT IDH1
42 central nervous system benign neoplasm 9.6 IDH2 IDH1
43 systemic mastocytosis 9.6 IDH2 IDH1
44 juvenile pilocytic astrocytoma 9.6 MGMT IDH1
45 bile duct adenocarcinoma 9.5 IDH2 IDH1
46 interval angle-closure glaucoma 9.5 PAX3 IDH2 IDH1
47 glioma 9.4 IDH2 IDH1 FOXO1
48 infratentorial cancer 9.4 MGMT IDH1
49 intrahepatic cholangiocarcinoma 9.4 IDH2 IDH1
50 adult brain stem glioma 9.4 MGMT IDH2 IDH1

Graphical network of the top 20 diseases related to Central Nervous System Rhabdomyosarcoma:



Diseases related to Central Nervous System Rhabdomyosarcoma

Symptoms & Phenotypes for Central Nervous System Rhabdomyosarcoma

MGI Mouse Phenotypes related to Central Nervous System Rhabdomyosarcoma:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 neoplasm MP:0002006 8.92 FOXO1 IDH2 MGMT PAX3

Drugs & Therapeutics for Central Nervous System Rhabdomyosarcoma

Search Clinical Trials , NIH Clinical Center for Central Nervous System Rhabdomyosarcoma

Genetic Tests for Central Nervous System Rhabdomyosarcoma

Anatomical Context for Central Nervous System Rhabdomyosarcoma

Publications for Central Nervous System Rhabdomyosarcoma

Articles related to Central Nervous System Rhabdomyosarcoma:

# Title Authors PMID Year
1
Primary intraventricular central nervous system rhabdomyosarcoma. 61
25444091 2015
2
DNA repair alterations in common pediatric malignancies. 61
18160950 2008

Variations for Central Nervous System Rhabdomyosarcoma

Expression for Central Nervous System Rhabdomyosarcoma

Search GEO for disease gene expression data for Central Nervous System Rhabdomyosarcoma.

Pathways for Central Nervous System Rhabdomyosarcoma

Pathways related to Central Nervous System Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.87 IDH2 IDH1
2
Show member pathways
9.74 IDH2 IDH1

GO Terms for Central Nervous System Rhabdomyosarcoma

Biological processes related to Central Nervous System Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 tricarboxylic acid cycle GO:0006099 9.32 IDH2 IDH1
2 2-oxoglutarate metabolic process GO:0006103 9.26 IDH2 IDH1
3 NADP metabolic process GO:0006739 9.16 IDH2 IDH1
4 isocitrate metabolic process GO:0006102 8.96 IDH2 IDH1
5 glyoxylate cycle GO:0006097 8.62 IDH2 IDH1

Molecular functions related to Central Nervous System Rhabdomyosarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 NAD binding GO:0051287 9.26 IDH2 IDH1
2 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor GO:0016616 9.16 IDH2 IDH1
3 isocitrate dehydrogenase (NADP+) activity GO:0004450 8.96 IDH2 IDH1
4 isocitrate dehydrogenase activity GO:0004448 8.62 IDH2 IDH1

Sources for Central Nervous System Rhabdomyosarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....