MCID: CNT045
MIFTS: 24

Central Nervous System Sarcoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Sarcoma

MalaCards integrated aliases for Central Nervous System Sarcoma:

Name: Central Nervous System Sarcoma 12 15 73
Sarcoma of the Cns 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2133
NCIt 50 C5153
UMLS 73 C1332892

Summaries for Central Nervous System Sarcoma

MalaCards based summary : Central Nervous System Sarcoma, also known as sarcoma of the cns, is related to kaposi sarcoma and central nervous system angiosarcoma. An important gene associated with Central Nervous System Sarcoma is SMARCA4 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 4), and among its related pathways/superpathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and BRCA1 Pathway. Related phenotypes are hematopoietic system and immune system

Related Diseases for Central Nervous System Sarcoma

Graphical network of the top 20 diseases related to Central Nervous System Sarcoma:



Diseases related to Central Nervous System Sarcoma

Symptoms & Phenotypes for Central Nervous System Sarcoma

MGI Mouse Phenotypes related to Central Nervous System Sarcoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.35 CD163 CD68 LYZ SMARCA4 SMARCB1
2 immune system MP:0005387 9.02 CD163 CD68 LYZ SMARCA4 SMARCB1

Drugs & Therapeutics for Central Nervous System Sarcoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Outcomes and Risk in People With Ependymoma Recruiting NCT03251989

Search NIH Clinical Center for Central Nervous System Sarcoma

Genetic Tests for Central Nervous System Sarcoma

Anatomical Context for Central Nervous System Sarcoma

Publications for Central Nervous System Sarcoma

Articles related to Central Nervous System Sarcoma:

# Title Authors Year
1
Association of central nervous system sarcoma with familial polyposis coli. ( 386305 )
1978

Variations for Central Nervous System Sarcoma

Expression for Central Nervous System Sarcoma

Search GEO for disease gene expression data for Central Nervous System Sarcoma.

Pathways for Central Nervous System Sarcoma

Pathways related to Central Nervous System Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.32 CD163 CD68
2
Show member pathways
11.07 SMARCA4 SMARCB1
3
Show member pathways
10.8 SMARCA4 SMARCB1
4 10.37 SMARCA4 SMARCB1

GO Terms for Central Nervous System Sarcoma

Cellular components related to Central Nervous System Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 SWI/SNF complex GO:0016514 9.16 SMARCA4 SMARCB1
2 nBAF complex GO:0071565 8.96 SMARCA4 SMARCB1
3 npBAF complex GO:0071564 8.62 SMARCA4 SMARCB1

Biological processes related to Central Nervous System Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin remodeling GO:0006338 9.43 SMARCA4 SMARCB1
2 positive regulation of DNA binding transcription factor activity GO:0051091 9.4 SMARCA4 SMARCB1
3 ATP-dependent chromatin remodeling GO:0043044 9.37 SMARCA4 SMARCB1
4 nucleosome disassembly GO:0006337 9.32 SMARCA4 SMARCB1
5 positive regulation by host of viral transcription GO:0043923 9.26 SMARCA4 SMARCB1
6 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I GO:1901838 9.16 SMARCA4 SMARCB1
7 RNA polymerase I transcriptional preinitiation complex assembly GO:0001188 8.96 SMARCA4 SMARCB1
8 positive regulation of glucose mediated signaling pathway GO:1902661 8.62 SMARCA4 SMARCB1

Molecular functions related to Central Nervous System Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RNA polymerase II distal enhancer sequence-specific DNA binding GO:0000980 9.32 SMARCA4 SMARCB1
2 p53 binding GO:0002039 9.26 SMARCA4 SMARCB1
3 nucleosomal DNA binding GO:0031492 9.16 SMARCA4 SMARCB1
4 Tat protein binding GO:0030957 8.96 SMARCA4 SMARCB1
5 RNA polymerase I CORE element sequence-specific DNA binding GO:0001164 8.62 SMARCA4 SMARCB1

Sources for Central Nervous System Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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