MCID: CNT045
MIFTS: 25

Central Nervous System Sarcoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Sarcoma

MalaCards integrated aliases for Central Nervous System Sarcoma:

Name: Central Nervous System Sarcoma 12 15 70
Sarcoma of the Cns 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2133
NCIt 50 C5153
UMLS 70 C1332892

Summaries for Central Nervous System Sarcoma

Disease Ontology : 12 A central nervous system cancer develops from transformed cells of mesenchymal origin located in brain and spine, has material basis in abnormally proliferating cells derives from mesoderm.

MalaCards based summary : Central Nervous System Sarcoma, also known as sarcoma of the cns, is related to kaposi sarcoma and central nervous system angiosarcoma. An important gene associated with Central Nervous System Sarcoma is SMARCB1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily B, Member 1), and among its related pathways/superpathways are Tight junction and Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell. Affiliated tissues include brain, thymus and bone.

Related Diseases for Central Nervous System Sarcoma

Diseases related to Central Nervous System Sarcoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 69)
# Related Disease Score Top Affiliating Genes
1 kaposi sarcoma 11.3
2 central nervous system angiosarcoma 11.2
3 reticulum cell sarcoma 10.0
4 pleuropulmonary blastoma 10.0
5 sarcoma 10.0
6 spindle cell sarcoma 10.0
7 embryoma 10.0
8 dicer1 tumor predisposition 10.0
9 rare tumor 10.0
10 histiocytosis 10.0 CD1C CD1A
11 predominantly cortical thymoma 9.9 CD1E CD1A
12 tolosa-hunt syndrome 9.9 CD1E CD1A
13 dendritic cell thymoma 9.9 CD1E CD1A
14 multifocal motor neuropathy 9.8 CD1E CD1A
15 oral hairy leukoplakia 9.8 CD1E CD1A
16 pityriasis rosea 9.8 CD1E CD1A
17 kimura disease 9.8 CD1E CD1A
18 skin sarcoidosis 9.8 CD1C CD1B
19 juvenile xanthogranuloma 9.7 CD1E CD1A
20 mite infestation 9.6 CD1B CD1A
21 langerhans cell histiocytosis 9.6 CD1C CD1A
22 granulomatous dermatitis 9.5 CD1E CD1C CD1B
23 mixed type thymoma 9.5 CD1E CD1B CD1A
24 encapsulated thymoma 9.5 CD1E CD1B CD1A
25 sphenoid sinusitis 9.5 CD1E CD1B CD1A
26 chronic laryngitis 9.5 CD1E CD1B CD1A
27 epithelial malignant thymoma 9.5 CD1E CD1B CD1A
28 necrobiosis lipoidica 9.5 CD1E CD1B CD1A
29 mycobacterium tuberculosis 1 9.4 CD1C CD1B CD1A
30 malignant histiocytic disease 9.3 CD1E CD1C CD1B CD1A
31 mycobacterium malmoense 9.3 CD1E CD1C CD1B CD1A
32 lichen nitidus 9.3 CD1E CD1C CD1B CD1A
33 phlyctenulosis 9.3 CD1E CD1C CD1B CD1A
34 rhinoscleroma 9.3 CD1E CD1C CD1B CD1A
35 reticulohistiocytic granuloma 9.3 CD1E CD1C CD1B CD1A
36 inflamed seborrheic keratosis 9.3 CD1E CD1C CD1B CD1A
37 balloon cell malignant melanoma 9.3 CD1E CD1C CD1B CD1A
38 langerhans cell sarcoma 9.3 CD1E CD1C CD1B CD1A
39 spongiotic dermatitis 9.3 CD1E CD1C CD1B CD1A
40 interdigitating dendritic cell sarcoma 9.3 CD1E CD1C CD1B CD1A
41 diencephalic astrocytoma 9.3 CD1E CD1C CD1B CD1A
42 orbital cancer 9.3 CD1E CD1C CD1B CD1A
43 granuloma annulare 9.3 CD1E CD1C CD1B CD1A
44 marginal corneal ulcer 9.3 CD1E CD1C CD1B CD1A
45 histiocytic and dendritic cell cancer 9.3 CD1E CD1C CD1B CD1A
46 non-langerhans-cell histiocytosis 9.2 CD1E CD1C CD1B CD1A
47 polyclonal hypergammaglobulinemia 9.2 CD1E CD1C CD1B CD1A
48 pilar sheath acanthoma 9.2 CD1E CD1C CD1B CD1A
49 acanthoma 9.2 CD1E CD1C CD1B CD1A
50 diencephalic neoplasm 9.2 CD1E CD1C CD1B CD1A

Graphical network of the top 20 diseases related to Central Nervous System Sarcoma:



Diseases related to Central Nervous System Sarcoma

Symptoms & Phenotypes for Central Nervous System Sarcoma

Drugs & Therapeutics for Central Nervous System Sarcoma

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A Pilot Study of StrataXRT, a Topical Silicone Barrier, to Prevent Auricular Radiation Dermatitis in Pediatric Patients Undergoing Proton Cerebrospinal Radiation Therapy Withdrawn NCT03990597 Phase 1 Wound Dressing Material

Search NIH Clinical Center for Central Nervous System Sarcoma

Genetic Tests for Central Nervous System Sarcoma

Anatomical Context for Central Nervous System Sarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Central Nervous System Sarcoma:

19
Brain

MalaCards organs/tissues related to Central Nervous System Sarcoma:

40
Thymus, Bone, Skin

Publications for Central Nervous System Sarcoma

Articles related to Central Nervous System Sarcoma:

# Title Authors PMID Year
1
A novel ATXN1-DUX4 fusion expands the spectrum of 'CIC-rearranged sarcoma' of the CNS to include non-CIC alterations. 61
33550509 2021
2
DICER1-associated central nervous system sarcoma in children: comprehensive clinicopathologic and genetic analysis of a newly described rare tumor. 61
32291395 2020
3
Pediatric intracerebral histiocytic sarcoma with rhabdoid features: Case report and literature review. 61
28748542 2017
4
Association of central nervous system sarcoma with familial polyposis coli. 61
386305 1978

Variations for Central Nervous System Sarcoma

Expression for Central Nervous System Sarcoma

Search GEO for disease gene expression data for Central Nervous System Sarcoma.

Pathways for Central Nervous System Sarcoma

Pathways related to Central Nervous System Sarcoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.68 CD1E CD1C CD1B CD1A
2 11.56 CD1C CD1B CD1A
3 11.27 CD1E CD1C CD1B CD1A
4 11.19 CD1C CD1A
5 10.92 CD1E CD1C CD1B CD1A

GO Terms for Central Nervous System Sarcoma

Cellular components related to Central Nervous System Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.62 CD1E CD1C CD1B CD1A
2 lysosome GO:0005764 9.43 CD1E CD1C CD1B
3 endosome membrane GO:0010008 9.33 CD1C CD1B CD1A
4 endosome GO:0005768 9.26 CD1E CD1C CD1B CD1A
5 external side of plasma membrane GO:0009897 8.92 CD1E CD1C CD1B CD1A

Biological processes related to Central Nervous System Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.67 CD1E CD1C CD1B CD1A
2 immune response GO:0006955 9.62 CD1E CD1C CD1B CD1A
3 regulation of immune response GO:0050776 9.58 CD1C CD1B CD1A
4 adaptive immune response GO:0002250 9.56 CD1E CD1C CD1B CD1A
5 positive regulation of T cell mediated cytotoxicity GO:0001916 9.46 CD1E CD1C CD1B CD1A
6 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.26 CD1E CD1C CD1B CD1A
7 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 8.92 CD1E CD1C CD1B CD1A

Molecular functions related to Central Nervous System Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.46 CD1E CD1C CD1B CD1A
2 exogenous lipid antigen binding GO:0030884 9.26 CD1E CD1C CD1B CD1A
3 endogenous lipid antigen binding GO:0030883 8.92 CD1E CD1C CD1B CD1A

Sources for Central Nervous System Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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