MCID: CNT045
MIFTS: 29

Central Nervous System Sarcoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Sarcoma

MalaCards integrated aliases for Central Nervous System Sarcoma:

Name: Central Nervous System Sarcoma 12 15 74
Sarcoma of the Cns 12

Classifications:



External Ids:

Disease Ontology 12 DOID:2133
NCIt 51 C5153
UMLS 74 C1332892

Summaries for Central Nervous System Sarcoma

Disease Ontology : 12 A central nervous system cancer develops from transformed cells of mesenchymal origin located in brain and spine, has material basis in abnormally proliferating cells derives from mesoderm.

MalaCards based summary : Central Nervous System Sarcoma, also known as sarcoma of the cns, is related to kaposi sarcoma and central nervous system angiosarcoma. An important gene associated with Central Nervous System Sarcoma is SMARCA4 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator Of Chromatin, Subfamily A, Member 4), and among its related pathways/superpathways are Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell and Tight junction. The drugs Sunitinib and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include brain and brain.

Related Diseases for Central Nervous System Sarcoma

Graphical network of the top 20 diseases related to Central Nervous System Sarcoma:



Diseases related to Central Nervous System Sarcoma

Symptoms & Phenotypes for Central Nervous System Sarcoma

Drugs & Therapeutics for Central Nervous System Sarcoma

Drugs for Central Nervous System Sarcoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Sunitinib Approved, Investigational Phase 2 557795-19-4, 341031-54-7 5329102
2 Angiogenesis Inhibitors Phase 2
3 Protein Kinase Inhibitors Phase 2
4 Angiogenesis Modulating Agents Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Sunitinib in Sarcomas of the Central Nervous System Recruiting NCT03641326 Phase 2 Sunitinib
2 Rare CNS Tumors Outcomes &Risk Recruiting NCT03251989

Search NIH Clinical Center for Central Nervous System Sarcoma

Genetic Tests for Central Nervous System Sarcoma

Anatomical Context for Central Nervous System Sarcoma

The Foundational Model of Anatomy Ontology organs/tissues related to Central Nervous System Sarcoma:

20
Brain

MalaCards organs/tissues related to Central Nervous System Sarcoma:

42
Brain

Publications for Central Nervous System Sarcoma

Articles related to Central Nervous System Sarcoma:

# Title Authors Year
1
Association of central nervous system sarcoma with familial polyposis coli. ( 386305 )
1978

Variations for Central Nervous System Sarcoma

Expression for Central Nervous System Sarcoma

Search GEO for disease gene expression data for Central Nervous System Sarcoma.

Pathways for Central Nervous System Sarcoma

GO Terms for Central Nervous System Sarcoma

Cellular components related to Central Nervous System Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 integral component of plasma membrane GO:0005887 9.83 CD163 CD1A CD1C CD1D CD1E
2 lysosomal membrane GO:0005765 9.63 CD1B CD1D CD68
3 lysosome GO:0005764 9.56 CD1B CD1C CD1D CD1E
4 cell surface GO:0009986 9.55 CD1A CD1B CD1C CD1D CD1E
5 endosome GO:0005768 9.43 CD1A CD1B CD1C CD1D CD1E CD68
6 SWI/SNF complex GO:0016514 9.4 SMARCA4 SMARCB1
7 nBAF complex GO:0071565 9.37 SMARCA4 SMARCB1
8 npBAF complex GO:0071564 9.32 SMARCA4 SMARCB1
9 endosome membrane GO:0010008 9.02 CD1A CD1B CD1C CD1D CD68
10 plasma membrane GO:0005886 10.02 CD163 CD1A CD1B CD1C CD1D CD1E

Biological processes related to Central Nervous System Sarcoma according to GeneCards Suite gene sharing:

(show all 13)
# Name GO ID Score Top Affiliating Genes
1 immune system process GO:0002376 9.8 CD1A CD1B CD1C CD1D CD1E
2 adaptive immune response GO:0002250 9.73 CD1A CD1B CD1C CD1E
3 regulation of immune response GO:0050776 9.67 CD1A CD1B CD1C CD1D
4 immune response GO:0006955 9.65 CD1A CD1B CD1C CD1D CD1E
5 positive regulation of T cell mediated cytotoxicity GO:0001916 9.55 CD1A CD1B CD1C CD1D CD1E
6 ATP-dependent chromatin remodeling GO:0043044 9.52 SMARCA4 SMARCB1
7 nucleosome disassembly GO:0006337 9.51 SMARCA4 SMARCB1
8 positive regulation by host of viral transcription GO:0043923 9.49 SMARCA4 SMARCB1
9 positive regulation of transcription of nucleolar large rRNA by RNA polymerase I GO:1901838 9.48 SMARCA4 SMARCB1
10 RNA polymerase I preinitiation complex assembly GO:0001188 9.46 SMARCA4 SMARCB1
11 antigen processing and presentation, exogenous lipid antigen via MHC class Ib GO:0048007 9.35 CD1A CD1B CD1C CD1D CD1E
12 positive regulation of glucose mediated signaling pathway GO:1902661 9.32 SMARCA4 SMARCB1
13 antigen processing and presentation, endogenous lipid antigen via MHC class Ib GO:0048006 9.02 CD1A CD1B CD1C CD1D CD1E

Molecular functions related to Central Nervous System Sarcoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 lipopeptide binding GO:0071723 9.55 CD1A CD1B CD1C CD1D CD1E
2 p53 binding GO:0002039 9.4 SMARCA4 SMARCB1
3 nucleosomal DNA binding GO:0031492 9.37 SMARCA4 SMARCB1
4 endogenous lipid antigen binding GO:0030883 9.35 CD1A CD1B CD1C CD1D CD1E
5 Tat protein binding GO:0030957 9.32 SMARCA4 SMARCB1
6 RNA polymerase I CORE element sequence-specific DNA binding GO:0001164 9.26 SMARCA4 SMARCB1
7 exogenous lipid antigen binding GO:0030884 9.02 CD1A CD1B CD1C CD1D CD1E

Sources for Central Nervous System Sarcoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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