MCID: CNT007
MIFTS: 35

Central Nervous System Tuberculosis

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Tuberculosis

MalaCards integrated aliases for Central Nervous System Tuberculosis:

Name: Central Nervous System Tuberculosis 12 15 17
Tuberculosis, Central Nervous System 45 74
Intracranial Tuberculoma 12 74
Tuberculosis of Meninges and Central Nervous System 12
Tuberculous Abscess of Brain 12
Tuberculoma, Intracranial 45
Tuberculoma of Brain 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1638
ICD9CM 36 013.2 013.20
SNOMED-CT 69 40769007

Summaries for Central Nervous System Tuberculosis

Disease Ontology : 12 An extrapulmonary tuberculosis that results in formation of tuberculomas located in brain or located in spinal cord.

MalaCards based summary : Central Nervous System Tuberculosis, also known as tuberculosis, central nervous system, is related to mycobacterium tuberculosis 1 and meningitis. An important gene associated with Central Nervous System Tuberculosis is MMP9 (Matrix Metallopeptidase 9). The drugs Dexamethasone acetate and Dexamethasone have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and liver.

Related Diseases for Central Nervous System Tuberculosis

Graphical network of the top 20 diseases related to Central Nervous System Tuberculosis:



Diseases related to Central Nervous System Tuberculosis

Symptoms & Phenotypes for Central Nervous System Tuberculosis

Drugs & Therapeutics for Central Nervous System Tuberculosis

Drugs for Central Nervous System Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 78)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Dexamethasone acetate Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 1177-87-3
2
Dexamethasone Approved, Investigational, Vet_approved Phase 4,Phase 2,Phase 3 50-02-2 5743
3 Peripheral Nervous System Agents Phase 4,Phase 2,Phase 3
4 Anti-Inflammatory Agents Phase 4,Phase 2,Phase 3
5 HIV Protease Inhibitors Phase 4,Phase 2,Phase 3
6 Hormones Phase 4,Phase 2,Phase 3
7
protease inhibitors Phase 4,Phase 2,Phase 3
8 Autonomic Agents Phase 4,Phase 2,Phase 3
9 BB 1101 Phase 4,Phase 2,Phase 3
10 Antineoplastic Agents, Hormonal Phase 4,Phase 2,Phase 3
11 Hormone Antagonists Phase 4,Phase 2,Phase 3
12 Antiemetics Phase 4,Phase 2,Phase 3
13 Gastrointestinal Agents Phase 4,Phase 2,Phase 3
14 glucocorticoids Phase 4,Phase 2,Phase 3
15 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
16
Pyrazinamide Approved, Investigational Phase 2, Phase 3,Phase 1 98-96-4 1046
17
Rifampicin Approved Phase 2, Phase 3,Phase 1 13292-46-1 5381226 5458213
18
Ethambutol Approved Phase 2, Phase 3,Phase 1 74-55-5 3279 14052
19
Folic Acid Approved, Nutraceutical, Vet_approved Phase 2, Phase 3 59-30-3 6037
20
Pyridoxine Approved, Investigational, Nutraceutical, Vet_approved Phase 2, Phase 3,Phase 3 65-23-6 1054
21 Nucleic Acid Synthesis Inhibitors Phase 2, Phase 3,Phase 1,Not Applicable
22 Cytochrome P-450 CYP3A Inducers Phase 2, Phase 3,Phase 1,Not Applicable
23 Anti-Infective Agents Phase 2, Phase 3,Phase 1,Not Applicable
24 Vitamin B 6 Phase 2, Phase 3
25 Antitubercular Agents Phase 2, Phase 3,Phase 3,Phase 1,Not Applicable
26 Vitamin B9 Phase 2, Phase 3
27 Folate Phase 2, Phase 3
28 Antibiotics, Antitubercular Phase 2, Phase 3,Phase 1
29 Micronutrients Phase 2, Phase 3
30 Nutrients Phase 2, Phase 3
31 Vitamin B Complex Phase 2, Phase 3
32 Trace Elements Phase 2, Phase 3
33 Vitamins Phase 2, Phase 3
34 Anti-Bacterial Agents Phase 2, Phase 3,Phase 1,Not Applicable
35 Liver Extracts Phase 3
36
Pyridoxal Experimental, Nutraceutical Phase 2, Phase 3 66-72-8 1050
37
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
38
Estradiol Approved, Investigational, Vet_approved Phase 2 50-28-2 5757
39
Ethinyl Estradiol Approved Phase 2 57-63-6 5991
40
Polyestradiol phosphate Approved Phase 2 28014-46-2
41
Moxifloxacin Approved, Investigational Phase 2 354812-41-2, 151096-09-2 152946
42
Norgestimate Approved, Investigational Phase 2 35189-28-7 6540478
43
Isoniazid Approved, Investigational Phase 1, Phase 2,Phase 2,Not Applicable 54-85-3 3767
44
Levofloxacin Approved, Investigational Phase 1, Phase 2 100986-85-4 149096
45
Ofloxacin Approved Phase 1, Phase 2 82419-36-1 4583
46
Linezolid Approved, Investigational Phase 2 165800-03-3 441401
47 Cytochrome P-450 Enzyme Inhibitors Phase 1, Phase 2,Not Applicable
48 Fibrinolytic Agents Phase 2
49 Cyclooxygenase Inhibitors Phase 2
50 Anti-Inflammatory Agents, Non-Steroidal Phase 2

Interventional clinical trials:

(show all 15)
# Name Status NCT ID Phase Drugs
1 The Relationships Between Gene Polymorphisms of LTA4H and Dexamethasone Treatment for Tuberculous Meningitis Unknown status NCT02588196 Phase 4 Dexamethasone acetate
2 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Completed NCT01589289 Phase 3
3 High-dose Rifampicin for the Treatment of Tuberculous Meningitis: a Dose-finding Study Completed NCT02169882 Phase 2, Phase 3 Placebo;Rifampicin;Other TB drugs;Adjuvant dexamethasone
4 Leukotriene A4 Hydrolase Stratified Trial of Adjunctive Corticosteroids for HIV-uninfected Adults With Tuberculous Meningitis Recruiting NCT03100786 Phase 3 Dexamethasone
5 Adjunctive Corticosteroids for Tuberculous Meningitis in HIV-infected Adults (The ACT HIV Trial) Recruiting NCT03092817 Phase 3 Dexamethasone
6 A Pilot Study of Adjunctive Aspirin for the Treatment of HIV Negative Adults With Tuberculous Meningitis Completed NCT02237365 Phase 2 81mg aspirin;1000mg aspirin;Placebo
7 Rifampicin Explorative PK Study for Tuberculous Meningitis Comparing Oral and Intravenous Preparation Completed NCT01802502 Phase 2 Rifampicin intravenous;Oral rifampicin
8 Intensified Treatment Regimens for TB Meningitis: PK, PD and Tolerability Study Completed NCT01158755 Phase 2 Moxifloxacin
9 Optimizing Treatment to Improve TBM Outcomes in Children Recruiting NCT02958709 Phase 1, Phase 2 High-dose: RIF, INH, PZA, EMB;High dose: RIF, INH, PZA, LEVO;Standard of care: RIF, INH, PZA, EMB
10 Pharmacokinetic Study of Linezolid for TB Meningitis Not yet recruiting NCT03537495 Phase 2 Linezolid
11 Immediate Versus Deferred Antiretroviral Therapy for HIV-Associated Tuberculous Meningitis Unknown status NCT00433719 Not Applicable Combivir and efavirenz
12 Diagnosis of Tuberculous Meningitis by ESAT-6 in CSF Completed NCT01371916
13 Study Of The Long Term Outcome Of Tuberculous Meningitis In Vietnamese Adults Treated With Adjunctive Dexamethasone Completed NCT01317654
14 Retrospective Real-word Study of Linezolid for the Treatment of Tuberculous Meningitis Recruiting NCT03898635 Linezolid
15 Optimizing Antituberculosis Therapy in Adults With Tuberculous Meningitis Not yet recruiting NCT03787940 Not Applicable Isoniazid

Search NIH Clinical Center for Central Nervous System Tuberculosis

Cochrane evidence based reviews: tuberculoma, intracranial

Genetic Tests for Central Nervous System Tuberculosis

Anatomical Context for Central Nervous System Tuberculosis

MalaCards organs/tissues related to Central Nervous System Tuberculosis:

42
Brain, Spinal Cord, Liver, Testes, Lung, Lymph Node, Myeloid

The Foundational Model of Anatomy Ontology organs/tissues related to Central Nervous System Tuberculosis:

20
Brain Or

Publications for Central Nervous System Tuberculosis

Articles related to Central Nervous System Tuberculosis:

(show top 50) (show all 106)
# Title Authors Year
1
Practice Trends in Treating Central Nervous System Tuberculosis and Outcomes at a Tertiary Care Hospital: A Cohort Study of 244 Cases. ( 30692758 )
2019
2
Central Nervous System Tuberculosis - The Gray Area in Tuberculosis Treatment. ( 30765962 )
2019
3
Clinical Spectrum of Central Nervous System Tuberculosis and the Efficacy of Revised National Tuberculosis Control Program in its Management. ( 30765974 )
2019
4
Spectrum of central nervous system tuberculosis: An experience from a large tertiary care institution of India. ( 30797283 )
2019
5
Central nervous system tuberculosis reactivation following intravenous iron supplementation. ( 30860189 )
2019
6
Matrix Metalloproteinases in Pulmonary and Central Nervous System Tuberculosis-A Review. ( 30889803 )
2019
7
Think central nervous system tuberculosis, also in low-risk children: a Danish nationwide survey. ( 30907215 )
2019
8
Radiological data in microbiologically confirmed central nervous system tuberculosis. ( 29906600 )
2018
9
Central nervous system tuberculosis mimicking tentorium meningioma: a rare case. ( 29768567 )
2018
10
Experimental animal models of central nervous system tuberculosis: A historical review. ( 29779764 )
2018
11
Clinical perspectives into the use of thalidomide for central nervous system tuberculosis. ( 29935038 )
2018
12
Outcomes of Pediatric Central Nervous System Tuberculosis in California, 1993-2011. ( 30189047 )
2018
13
Central Nervous System Tuberculosis : Etiology, Clinical Manifestations and Neuroradiological Features. ( 30225516 )
2018
14
Central nervous system tuberculosis following delayed and initially missed lung miliary tuberculosis: a case report. ( 30246772 )
2018
15
Study of Central Nervous System Tuberculosis. ( 30341844 )
2018
16
Atypical Clinical Presentation and Imaging Findings of Central Nervous System Tuberculosis. ( 30430973 )
2018
17
Successful rapid oral desensitization for dual hypersensitivity to isoniazid and rifampin while treating central nervous system tuberculosis. ( 30559942 )
2018
18
Central Nervous System Tuberculosis. ( 28281443 )
2017
19
Central nervous system Tuberculosis in a man from Cambodia with worsening headaches. ( 29026544 )
2017
20
Ruptured intracranial tuberculous aneurysm, a rare complication of central nervous system tuberculosis- A report and review of literature. ( 28488632 )
2017
21
Complex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosis. ( 28173836 )
2017
22
A scoring system to effectively evaluate central nervous system tuberculosis in patients with military tuberculosis. ( 28531173 )
2017
23
Myeloid and T Cell-Derived TNF Protects against Central Nervous System Tuberculosis. ( 28280495 )
2017
24
Nitric oxide in cerebrospinal fluid of central nervous system tuberculosis: correlations with culture, antibody response, and cell count. ( 28263476 )
2017
25
Correction: A scoring system to effectively evaluate central nervous system tuberculosis in patients with miliary tuberculosis. ( 28767710 )
2017
26
Central Nervous System Tuberculosis: An Imaging Perspective. ( 28283299 )
2017
27
Surface-modified gatifloxacin nanoparticles with potential for treating central nervous system tuberculosis. ( 28331318 )
2017
28
Factors Determining the Clinical Spectrum, Course and Response to Treatment, and Complications in Seronegative Patients with Central Nervous System Tuberculosis. ( 28479800 )
2017
29
Central Nervous System Tuberculosis in an Immigrant Child. ( 27231208 )
2016
30
Tuberculous ventriculitis: A rare complication of central nervous system tuberculosis. ( 27242238 )
2016
31
Immune reconstitution inflammatory syndrome in central nervous system tuberculosis. ( 27451593 )
2015
32
Immunoconfirmation of central nervous system tuberculosis by blotting: A study of 300 cases. ( 26972880 )
2015
33
Microglia are crucial regulators of neuro-immunity during central nervous system tuberculosis. ( 26041993 )
2015
34
Central nervous system tuberculosis reviewed. ( 26338350 )
2015
35
Central nervous system tuberculosis: an imaging-focused review of a reemerging disease. ( 25653877 )
2015
36
Risk Factors for Central Nervous System Tuberculosis. ( 26438712 )
2015
37
Does non-central nervous system tuberculosis increase the risk of ischemic stroke? A population-based propensity score-matched follow-up study. ( 25048551 )
2014
38
Cerebral infarction and tuberculoma in central nervous system tuberculosis: frequency and prognostic implications. ( 24623792 )
2014
39
Central nervous system tuberculosis. ( 24887691 )
2014
40
Central nervous system tuberculosis. ( 25241567 )
2014
41
A rare case of central nervous system tuberculosis. ( 25478256 )
2014
42
Characteristics of central nervous system tuberculosis in a low-incidence country: a series of 20 cases and a review of the literature. ( 24451103 )
2014
43
HIV-associated central nervous system tuberculosis. ( 24715493 )
2014
44
Central nervous system tuberculosis presenting as branch retinal vein occlusion. ( 22738141 )
2013
45
Central Nervous System Tuberculosis: Challenges and Advances in Diagnosis and Treatment. ( 24122343 )
2013
46
Central nervous system tuberculosis: a disease from Papua New Guinea in North Queensland. ( 23480051 )
2013
47
The dual face of central nervous system tuberculosis: a new Janus Bifrons? ( 23305698 )
2013
48
Central nervous system tuberculosis: pathophysiology and imaging findings. ( 23122262 )
2012
49
A life-threatening central nervous system-tuberculosis inflammatory reaction nonresponsive to corticosteroids and successfully controlled by infliximab in a young patient with a variant of juvenile idiopathic arthritis. ( 22647865 )
2012
50
Role of Mycobacterium tuberculosis pknD in the pathogenesis of central nervous system tuberculosis. ( 22243650 )
2012

Variations for Central Nervous System Tuberculosis

Expression for Central Nervous System Tuberculosis

Search GEO for disease gene expression data for Central Nervous System Tuberculosis.

Pathways for Central Nervous System Tuberculosis

GO Terms for Central Nervous System Tuberculosis

Sources for Central Nervous System Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
Content
Loading form....