MCID: CNT007
MIFTS: 35

Central Nervous System Tuberculosis

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Tuberculosis

MalaCards integrated aliases for Central Nervous System Tuberculosis:

Name: Central Nervous System Tuberculosis 12 15 17
Intracranial Tuberculoma 12 71
Tuberculosis of Meninges and Central Nervous System 12
Tuberculosis, Central Nervous System 71
Tuberculous Abscess of Brain 12
Tuberculoma, Intracranial 44
Tuberculoma of Brain 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1638
ICD9CM 34 013.2
MeSH 44 D016862
SNOMED-CT 67 40769007
UMLS 71 C0085388 C0275904

Summaries for Central Nervous System Tuberculosis

Disease Ontology : 12 An extrapulmonary tuberculosis that results in formation of tuberculomas located in brain or located in spinal cord.

MalaCards based summary : Central Nervous System Tuberculosis, also known as intracranial tuberculoma, is related to tuberculous meningitis and mycobacterium tuberculosis 1. An important gene associated with Central Nervous System Tuberculosis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways is Cytokines and Inflammatory Response. The drugs Mesna and Cyclophosphamide have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and myeloid.

Related Diseases for Central Nervous System Tuberculosis

Diseases related to Central Nervous System Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 237)
# Related Disease Score Top Affiliating Genes
1 tuberculous meningitis 31.3 TNF MMP9 ADA
2 mycobacterium tuberculosis 1 31.3 TNF CD4 ADA
3 arachnoiditis 31.0 TNF CD4
4 chronic meningitis 30.7 MMP9 MIR642A CD4
5 miliary tuberculosis 30.7 TNF CD4 ADA
6 meningitis 30.5 TNF MMP9 ADA
7 acquired immunodeficiency syndrome 30.5 TNF CD4 ADA
8 cerebritis 30.3 TNF CD4
9 choroiditis 30.2 TNF CD4
10 fungal meningitis 30.2 TNF CD4
11 retinal vasculitis 30.2 TNF CD4
12 multidrug-resistant tuberculosis 30.2 TNF CD4
13 abdominal tuberculosis 30.0 TNF CD4 ADA
14 cryptococcal meningitis 29.7 CD4 ADA
15 hydrocephalus 10.7
16 spinal arachnoiditis 10.5
17 inflammatory spondylopathy 10.3
18 spondylitis 10.3
19 pulmonary tuberculosis 10.3
20 parotitis 10.3 MMP9 CD4
21 pericardial tuberculosis 10.3 CD4 ADA
22 splenic tuberculosis 10.3 CD4 ADA
23 autoimmune inner ear disease 10.3 TNF MMP9
24 pleural empyema 10.3 CD4 ADA
25 cardiac rupture 10.2 TNF MMP9
26 coronary aneurysm 10.2 TNF MMP9
27 heart aneurysm 10.2 TNF MMP9
28 anal fistula 10.2 TNF MMP9
29 secondary hemophagocytic lymphohistiocytosis 10.2 TNF ADA
30 extrapulmonary tuberculosis 10.2
31 meningoencephalitis 10.2
32 vasculitis 10.2
33 listeria meningitis 10.2 TNF ADA
34 intracranial hypertension 10.2
35 lymphocytic colitis 10.2 TNF MMP9
36 hemorrhoid 10.2 TNF MMP9
37 periapical periodontitis 10.2 TNF MMP9
38 intestinal tuberculosis 10.2 TNF CD4
39 rheumatoid arthritis interstitial lung disease 10.2 TNF CD4
40 type 1 diabetes mellitus 23 10.2 TNF CD4
41 decubitus ulcer 10.2 TNF MMP9
42 meningovascular neurosyphilis 10.2 TNF CD4
43 skin sarcoidosis 10.2 TNF CD4
44 opportunistic bacterial infectious disease 10.2 TNF CD4
45 tertiary syphilis 10.2 TNF CD4
46 nocardiosis 10.2 TNF CD4
47 oral tuberculosis 10.2 TNF CD4
48 granuloma annulare 10.2 TNF CD4
49 granulomatous hepatitis 10.2 TNF CD4
50 viral exanthem 10.2 TNF CD4

Graphical network of the top 20 diseases related to Central Nervous System Tuberculosis:



Diseases related to Central Nervous System Tuberculosis

Symptoms & Phenotypes for Central Nervous System Tuberculosis

Drugs & Therapeutics for Central Nervous System Tuberculosis

Drugs for Central Nervous System Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 6)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mesna Approved, Investigational Phase 2, Phase 3 3375-50-6 598
2
Cyclophosphamide Approved, Investigational Phase 2, Phase 3 50-18-0, 6055-19-2 2907
3 Immunosuppressive Agents Phase 2, Phase 3
4 Immunologic Factors Phase 2, Phase 3
5 Antirheumatic Agents Phase 2, Phase 3
6 Alkylating Agents Phase 2, Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Rapid Diagnostic Tests in Association With Clinical and Laboratory Predictors for the Diagnosis of Neglected Tropical Diseases in Patients With Neurological Disorders in Rural Hospitals of Bandundu,Democratic Republic of Congo Completed NCT01589289 Phase 3
2 Efficacy and Safety of Cyclophosphamide in the Treatment of Refractory Proliferative Arachnoiditis in Central Nervous System Tuberculosis- A Randomized Double Blinded Placebo Controlled Trial Not yet recruiting NCT04620772 Phase 2, Phase 3 Cyclophosphamide injection

Search NIH Clinical Center for Central Nervous System Tuberculosis

Cochrane evidence based reviews: tuberculoma, intracranial

Genetic Tests for Central Nervous System Tuberculosis

Anatomical Context for Central Nervous System Tuberculosis

The Foundational Model of Anatomy Ontology organs/tissues related to Central Nervous System Tuberculosis:

19
Brain, Spinal Cord

MalaCards organs/tissues related to Central Nervous System Tuberculosis:

40
Brain, Spinal Cord, Myeloid, Medulla Oblongata, Neutrophil, Cortex, Kidney

Publications for Central Nervous System Tuberculosis

Articles related to Central Nervous System Tuberculosis:

(show top 50) (show all 458)
# Title Authors PMID Year
1
Neurological issues during severe COVID-19 in a tertiary level hospital in Western India. 61
33592305 2021
2
Intramedullary Conus Medullaris Tuberculoma: A Case Report and Review of the Literature. 61
33467582 2021
3
The Use of Murine Infection Models to Investigate the Protective Role of TNF in Central Nervous System Tuberculosis. 61
33185878 2021
4
Presentations and outcomes of central nervous system TB in a UK cohort: The high burden of neurological morbidity. 61
33137354 2021
5
An Intracranial Tuberculoma with Discharging Scalp Sinus. 61
32611970 2021
6
Advances in tuberculous meningitis diagnosis. 61
33259249 2020
7
Clinical features of adult patients with a definite diagnosis of central nervous system tuberculosis in an endemic country: A 13-year retrospective review. 61
32995572 2020
8
Thalidomide use for complicated central nervous system tuberculosis in children: insights from an observational cohort. 61
33283220 2020
9
Central nervous system tuberculosis. 61
33387702 2020
10
The immunological architecture of granulomatous inflammation in central nervous system tuberculosis. 61
33137697 2020
11
Three-dimensional visualizations from a dataset of immunohistochemical stained serial sections of human brain tissue containing tuberculosis related granulomas. 61
33294523 2020
12
[Central nervous system tuberculosis : don't miss the diagnosis !] 61
33155442 2020
13
Double trouble with the disc - Hickam's dictum versus Occam's razor! 61
33120709 2020
14
Aggressive intracerebral tuberculoma in a 1-year-old child: A case report with literature review. 61
32983301 2020
15
A rare co-occurrence of optochiasmatic tuberculoma and guillain-barre syndrome as a paradoxical reaction in tubercular meningitis. 61
33323662 2020
16
Unusual Periventricular Hemorrhage as the Initial Manifestation of Central Nervous System Tuberculosis. 61
32615289 2020
17
Tumor necrosis factor antagonists for paradoxical inflammatory reactions in the central nervous system tuberculosis: Case report and review. 61
33120751 2020
18
Fatal central nervous system co-infection with SARS-CoV-2 and tuberculosis in a healthy child. 61
32907595 2020
19
Hemichorea-Hemiballism: An Uncommon Presentation of Central Nervous System Tuberculosis. 61
33015230 2020
20
Central Nervous System Tuberculosis With Shower Like Pattern of Intracranial Tuberculomas in an Immunocompetent Patient. 61
32968583 2020
21
Extra-central nervous system tuberculosis in HIV-uninfected patients of tuberculous meningitis: A prospective evaluation. 61
32439354 2020
22
Giant Tuberculomas of Brain: Rare Neoplastic Mimic. 61
33531933 2020
23
Neuromyelitis optica spectrum disorder (NMOSD) with hypothalamic involvement and central nervous system tuberculosis: A case report. 61
32163749 2020
24
Complete ablation of tumor necrosis factor decreases the production of IgA, IgG, and IgM in experimental central nervous system tuberculosis. 61
32742607 2020
25
Clinical, Imaging, and Laboratory Characteristics of Adult Mexican Patients with Tuberculous Meningitis: A Retrospective Cohort Study. 61
32175711 2020
26
Presentation and outcome of patients with intracranial tuberculoma in a high HIV prevalence setting. 61
32127108 2020
27
18FDG-PET is sensitive tool for detection of extracranial tuberculous foci in central nervous system tuberculosis - Preliminary observations from a tertiary care center in northern India. 61
31816525 2020
28
Central nervous system tuberculoma with miliary tuberculosis in the elderly. 61
32055443 2020
29
A Critically Ill Patient With Central Nervous System Tuberculosis and Negative Initial Workup. 61
32595583 2020
30
Miliary Brain Tuberculomas and Meningitis: Tuberculosis Beyond the Lungs. 61
33313004 2020
31
Multi-spectral Pattern of Clinical Presentation and the Resultant Outcome in Central Nervous System Tuberculosis: A Single Center Study on the Ubiquitous Pathogen. 61
31994016 2020
32
Ancient foe, serious weapon: Subarachnoid hemorrhage secondary to TB meningitis. 61
32983890 2020
33
Outcomes of Pediatric Central Nervous System Tuberculosis in California, 1993-2011. 61
30189047 2019
34
Uncommon case of Mycobacterium bovis brain abscess complicated by suppurative fistula, and review of the literature. 61
31713228 2019
35
Delamanid Central Nervous System Pharmacokinetics in Tuberculous Meningitis in Rabbits and Humans. 61
31383662 2019
36
Tuberculous encephalopathy without meningitis: A rare manifestation of disseminated tuberculosis. 61
31793515 2019
37
Stereotactic Aspiration in Management of Rare Case of Tuberculous Cerebellar Abscess. 61
31176834 2019
38
Bacterial Genotyping of Central Nervous System Tuberculosis in South Africa: Heterogenic Mycobacterium tuberculosis Infection and Predominance of Lineage 4. 61
31189579 2019
39
Panhypopituitarism- An unusual presenation of tuberculous meningitis. 61
31439193 2019
40
Coexisting Spinal Intramedullary and Intracranial Tuberculomas in an Immunocompetent Child. 61
31649775 2019
41
[Recurrent vomiting and headaches in a 26-year-old male patient]. 61
30980098 2019
42
[Disseminated tuberculosis revealed by obstructive and prerenal acute kidney failure]. 61
31097378 2019
43
Think central nervous system tuberculosis, also in low-risk children: a Danish nationwide survey. 61
30907215 2019
44
Changing trends of presentation of central nervous system tuberculosis: Relative prevalence of cranial and spinal tuberculosis and drug resistance patterns. 61
31347557 2019
45
Case report: an area postrema syndrome revealing a neuromyelitis optica spectrum disorder associated with central nervous system tuberculosis in a young Togolese (black African) woman. 61
30971218 2019
46
Matrix Metalloproteinases in Pulmonary and Central Nervous System Tuberculosis-A Review. 61
30889803 2019
47
Central Nervous System Tuberculosis : Etiology, Clinical Manifestations and Neuroradiological Features. 61
30225516 2019
48
Practice Trends in Treating Central Nervous System Tuberculosis and Outcomes at a Tertiary Care Hospital: A Cohort Study of 244 Cases. 61
30692758 2019
49
Spectrum of central nervous system tuberculosis: An experience from a large tertiary care institution of India. 61
30797283 2019
50
Central nervous system tuberculosis reactivation following intravenous iron supplementation. 61
30860189 2019

Variations for Central Nervous System Tuberculosis

Expression for Central Nervous System Tuberculosis

Search GEO for disease gene expression data for Central Nervous System Tuberculosis.

Pathways for Central Nervous System Tuberculosis

Pathways related to Central Nervous System Tuberculosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.09 TNF CD4

GO Terms for Central Nervous System Tuberculosis

Cellular components related to Central Nervous System Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.02 TNF SCUBE2 LRFN4 CD4 ADA

Biological processes related to Central Nervous System Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of T cell activation GO:0050870 9.26 CD4 ADA
2 macrophage differentiation GO:0030225 9.16 MMP9 CD4
3 embryonic digestive tract development GO:0048566 8.96 TNF ADA
4 positive regulation of calcium-mediated signaling GO:0050850 8.62 CD4 ADA

Sources for Central Nervous System Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
Content
Loading form....