MCID: CNT007
MIFTS: 34

Central Nervous System Tuberculosis

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Tuberculosis

MalaCards integrated aliases for Central Nervous System Tuberculosis:

Name: Central Nervous System Tuberculosis 12 15 17
Tuberculosis, Central Nervous System 43 71
Intracranial Tuberculoma 12 71
Tuberculosis of Meninges and Central Nervous System 12
Tuberculous Abscess of Brain 12
Tuberculoma, Intracranial 43
Tuberculoma of Brain 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1638
ICD9CM 34 013.2 013.20
SNOMED-CT 67 40769007
UMLS 71 C0085388 C0275904

Summaries for Central Nervous System Tuberculosis

Disease Ontology : 12 An extrapulmonary tuberculosis that results in formation of tuberculomas located in brain or located in spinal cord.

MalaCards based summary : Central Nervous System Tuberculosis, also known as tuberculosis, central nervous system, is related to tuberculous meningitis and miliary tuberculosis. An important gene associated with Central Nervous System Tuberculosis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Primary immunodeficiency and Syndecan-1-mediated signaling events. The drugs Fibrinolytic Agents and Plasminogen have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and testes.

Related Diseases for Central Nervous System Tuberculosis

Diseases related to Central Nervous System Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 178)
# Related Disease Score Top Affiliating Genes
1 tuberculous meningitis 31.0 MMP9 LTA4H ADA
2 miliary tuberculosis 30.8 CD4 ADA
3 chronic meningitis 30.7 MMP9 CD4
4 meningitis 30.4 MMP9 LTA4H ADA
5 abdominal tuberculosis 30.1 CD4 ADA
6 pleural empyema 30.1 CD4 ADA
7 cryptococcal meningitis 30.0 CD4 ADA
8 extrapulmonary tuberculosis 30.0 CD4 ADA
9 lymph node tuberculosis 30.0 LTA4H CD4
10 mycobacterium tuberculosis 1 10.7
11 hydrocephalus 10.5
12 spinal arachnoiditis 10.3
13 arachnoiditis 10.3
14 intracranial hypertension 10.3
15 inflammatory spondylopathy 10.2
16 spondylitis 10.2
17 parotitis 10.2 MMP9 CD4
18 pericardial tuberculosis 10.2 CD4 ADA
19 cryptogenic organizing pneumonia 10.2 MMP9 CD4
20 gastrointestinal tuberculosis 10.2 CD4 ADA
21 immunodeficiency 19 10.2 CD4 ADA
22 pulmonary tuberculosis 10.2
23 acquired immunodeficiency syndrome 10.2
24 blepharitis 10.2 MMP9 CD4
25 eyelid disease 10.2 MMP9 CD4
26 cysticercosis 10.2
27 pleural tuberculosis 10.2 CD4 ADA
28 lacrimal apparatus disease 10.2 MMP9 CD4
29 gingival disease 10.1 MMP9 CD4
30 intestinal tuberculosis 10.1 LTA4H CD4
31 brain edema 10.1
32 glioma 10.1
33 seizure disorder 10.1
34 glial tumor 10.1
35 pericardium disease 10.1 CD4 ADA
36 cheilitis 10.1 MMP9 CD4
37 immune deficiency disease 10.0
38 meningoencephalitis 10.0
39 uveitis 10.0
40 hypothyroidism 10.0
41 communicating hydrocephalus 10.0
42 cranial nerve palsy 10.0
43 vasculitis 10.0
44 spinal cord infarction 10.0
45 chickenpox 10.0 CD4 ADA
46 hydrops, lactic acidosis, and sideroblastic anemia 10.0
47 visual epilepsy 10.0
48 lymphadenitis 10.0
49 toxoplasmosis 10.0
50 paresthesia 10.0

Graphical network of the top 20 diseases related to Central Nervous System Tuberculosis:



Diseases related to Central Nervous System Tuberculosis

Symptoms & Phenotypes for Central Nervous System Tuberculosis

Drugs & Therapeutics for Central Nervous System Tuberculosis

Drugs for Central Nervous System Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Fibrinolytic Agents
2 Plasminogen

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Rapid Diagnostic Tests in Association With Clinical and Laboratory Predictors for the Diagnosis of Neglected Tropical Diseases in Patients With Neurological Disorders in Rural Hospitals of Bandundu,Democratic Republic of Congo Completed NCT01589289 Phase 3
2 Relation Between Plasma Soluble Urokinase Plasminogen Activator Receptor and Behçet's Disease . Not yet recruiting NCT04105439

Search NIH Clinical Center for Central Nervous System Tuberculosis

Cochrane evidence based reviews: tuberculoma, intracranial

Genetic Tests for Central Nervous System Tuberculosis

Anatomical Context for Central Nervous System Tuberculosis

The Foundational Model of Anatomy Ontology organs/tissues related to Central Nervous System Tuberculosis:

19
Brain, Spinal Cord

MalaCards organs/tissues related to Central Nervous System Tuberculosis:

40
Brain, Spinal Cord, Testes, Lung, T Cells, Medulla Oblongata, Lymph Node

Publications for Central Nervous System Tuberculosis

Articles related to Central Nervous System Tuberculosis:

(show top 50) (show all 243)
# Title Authors PMID Year
1
Uncommon case of Mycobacterium bovis brain abscess complicated by suppurative fistula, and review of the literature. 61
31713228 2019
2
Outcomes of Pediatric Central Nervous System Tuberculosis in California, 1993-2011. 61
30189047 2019
3
18FDG-PET is sensitive tool for detection of extracranial tuberculous foci in central nervous system tuberculosis - Preliminary observations from a tertiary care center in northern India. 61
31816525 2019
4
Tuberculous encephalopathy without meningitis: A rare manifestation of disseminated tuberculosis. 61
31793515 2019
5
Delamanid Central Nervous System Pharmacokinetics in Tuberculous Meningitis in Rabbits and Humans. 61
31383662 2019
6
Stereotactic Aspiration in Management of Rare Case of Tuberculous Cerebellar Abscess. 61
31176834 2019
7
Bacterial Genotyping of Central Nervous System Tuberculosis in South Africa: Heterogenic Mycobacterium tuberculosis Infection and Predominance of Lineage 4. 61
31189579 2019
8
[Recurrent vomiting and headaches in a 26-year-old male patient]. 61
30980098 2019
9
Panhypopituitarism- An unusual presenation of tuberculous meningitis. 61
31439193 2019
10
Think central nervous system tuberculosis, also in low-risk children: a Danish nationwide survey. 61
30907215 2019
11
Changing trends of presentation of central nervous system tuberculosis: Relative prevalence of cranial and spinal tuberculosis and drug resistance patterns. 61
31347557 2019
12
Case report: an area postrema syndrome revealing a neuromyelitis optica spectrum disorder associated with central nervous system tuberculosis in a young Togolese (black African) woman. 61
30971218 2019
13
Matrix Metalloproteinases in Pulmonary and Central Nervous System Tuberculosis-A Review. 61
30889803 2019
14
Central Nervous System Tuberculosis : Etiology, Clinical Manifestations and Neuroradiological Features. 61
30225516 2019
15
Central nervous system tuberculosis reactivation following intravenous iron supplementation. 61
30860189 2019
16
Evaluation of cases of pediatric extrapulmonary tuberculosis: a single center experience. 61
31384143 2019
17
Spectrum of central nervous system tuberculosis: An experience from a large tertiary care institution of India. 61
30797283 2019
18
Genome-Wide miRNA Analysis Identifies Potential Biomarkers in Distinguishing Tuberculous and Viral Meningitis. 61
31572691 2019
19
Practice Trends in Treating Central Nervous System Tuberculosis and Outcomes at a Tertiary Care Hospital: A Cohort Study of 244 Cases. 61
30692758 2019
20
Bilateral primary optic neuropathy as the presenting manifestation of tuberculosis in an immunocompetent patient. 61
31367519 2019
21
Diagnosis and management of intracranial tuberculomas: about 2 cases and a review of the literature. 61
31762892 2019
22
Clinical Spectrum of Central Nervous System Tuberculosis and the Efficacy of Revised National Tuberculosis Control Program in its Management. 61
30765974 2019
23
Central Nervous System Tuberculosis - The Gray Area in Tuberculosis Treatment. 61
30765962 2019
24
Duration of anti-tuberculous therapy in children with persistent tuberculomas. 61
30671250 2019
25
Impact of Mycobacterium tuberculosis complex lineages as a determinant of disease phenotypes from an immigrant rich moderate tuberculosis burden country. 61
30587190 2018
26
Evaluation of intracranial tuberculomas using diffusion-weighted imaging (DWI), magnetic resonance spectroscopy (MRS) and susceptibility weighted imaging (SWI). 61
29987985 2018
27
Atypical Clinical Presentation and Imaging Findings of Central Nervous System Tuberculosis. 61
30430973 2018
28
Clinical perspectives into the use of thalidomide for central nervous system tuberculosis. 61
29935038 2018
29
Radiological data in microbiologically confirmed central nervous system tuberculosis. 61
29906600 2018
30
Tuberculosis of the central nervous system in children. 61
29978252 2018
31
Central nervous system tuberculosis following delayed and initially missed lung miliary tuberculosis: a case report. 61
30246772 2018
32
Isolated Tuberculoma Mimicking Foramen Magnum Meningioma in the Absence of Primary Tuberculosis: A Case Report. 61
30145853 2018
33
Management of Pediatric Posterior Circulation Aneurysms-12-Year Single-Institution Experience. 61
29778599 2018
34
Experimental animal models of central nervous system tuberculosis: A historical review. 61
29779764 2018
35
Central nervous system tuberculosis mimicking tentorium meningioma: a rare case. 61
29768567 2018
36
A rapid and simple resazurin assay to detect minimum inhibitory concentrations of first-line drugs for Mycobacterium tuberculosis isolated from cerebrospinal fluid. 61
28964954 2018
37
[Extramedullary intradural tuberculosis: a case report and review of the literature]. 61
29251339 2018
38
An Atypical Presentation of Tuberculomas in an Immunocompetent Host. 61
30186886 2018
39
Study of Central Nervous System Tuberculosis. 61
30341844 2018
40
Successful rapid oral desensitization for dual hypersensitivity to isoniazid and rifampin while treating central nervous system tuberculosis. 61
30559942 2018
41
Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis. 61
29167512 2017
42
Central nervous system Tuberculosis in a man from Cambodia with worsening headaches. 61
29026544 2017
43
Intracranial en-plaque tuberculoma impersonating en-plaque meningioma: Case report and brief review of literature. 61
28761548 2017
44
Choroid plexus tuberculoma. Diagnosis, management and role of endoscopy. 61
28678217 2017
45
Brain Tuberculoma: A Case Report and Literature Review. 61
28806025 2017
46
Tuberculous meningoencephalitis associated with brain tuberculomas during pregnancy: a case report. 61
28659187 2017
47
Old age and hydrocephalus are associated with poor prognosis in patients with tuberculous meningitis: A retrospective study in a Chinese adult population. 61
28658161 2017
48
Central Nervous System Tuberculosis: An Imaging Perspective. 61
28283299 2017
49
Ruptured intracranial tuberculous aneurysm, a rare complication of central nervous system tuberculosis- A report and review of literature. 61
28488632 2017
50
Factors Determining the Clinical Spectrum, Course and Response to Treatment, and Complications in Seronegative Patients with Central Nervous System Tuberculosis. 61
28479800 2017

Variations for Central Nervous System Tuberculosis

Expression for Central Nervous System Tuberculosis

Search GEO for disease gene expression data for Central Nervous System Tuberculosis.

Pathways for Central Nervous System Tuberculosis

Pathways related to Central Nervous System Tuberculosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.54 CD4 ADA
2 9.85 MMP9 CASK

GO Terms for Central Nervous System Tuberculosis

Cellular components related to Central Nervous System Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 8.92 SCUBE2 LRFN4 CD4 ADA

Biological processes related to Central Nervous System Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 T cell activation GO:0042110 9.26 CD4 ADA
2 positive regulation of T cell activation GO:0050870 9.16 CD4 ADA
3 macrophage differentiation GO:0030225 8.96 MMP9 CD4
4 positive regulation of calcium-mediated signaling GO:0050850 8.62 CD4 ADA

Sources for Central Nervous System Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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