MCID: CNT007
MIFTS: 39

Central Nervous System Tuberculosis

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Tuberculosis

MalaCards integrated aliases for Central Nervous System Tuberculosis:

Name: Central Nervous System Tuberculosis 12 15 17
Intracranial Tuberculoma 12 71
Tuberculosis of Meninges and Central Nervous System 12
Tuberculosis, Central Nervous System 71
Tuberculous Abscess of Brain 12
Tuberculoma, Intracranial 43
Tuberculoma of Brain 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1638
ICD9CM 34 013.2
MeSH 43 D016862
SNOMED-CT 67 416265003
UMLS 71 C0085388 C0275904

Summaries for Central Nervous System Tuberculosis

Disease Ontology : 12 An extrapulmonary tuberculosis that results in formation of tuberculomas located in brain or located in spinal cord.

MalaCards based summary : Central Nervous System Tuberculosis, also known as intracranial tuberculoma, is related to tuberculous meningitis and chronic meningitis. An important gene associated with Central Nervous System Tuberculosis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Toll-like Receptor Signaling Pathway and Colorectal Cancer Metastasis. The drug Plasminogen has been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and testes, and related phenotypes are digestive/alimentary and immune system

Related Diseases for Central Nervous System Tuberculosis

Diseases related to Central Nervous System Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 335)
# Related Disease Score Top Affiliating Genes
1 tuberculous meningitis 30.8 TNF MMP9 ADA
2 chronic meningitis 30.6 MMP9 MIR642A CD4
3 ocular tuberculosis 30.2 IFNG CD4
4 pleural empyema 30.2 CD4 ADA
5 mycobacterium tuberculosis 1 30.1 TNF IFNG CD4 ADA
6 pulmonary tuberculosis 29.9 TNF IFNG ADA
7 cryptococcal meningitis 29.8 IFNG CD4 ADA
8 meningitis 29.7 TNF MMP9 IFNG ADA
9 cerebritis 29.7 TNF CD4
10 miliary tuberculosis 29.6 TNF IFNG CD4 ADA
11 lymphadenitis 29.4 TNF IFNG CD4
12 acquired immunodeficiency syndrome 29.4 TNF IFNG CD4 ADA
13 bacterial meningitis 29.4 TNF MMP9 IFNG
14 neuritis 29.4 TNF MMP9 IFNG
15 choroiditis 29.3 TNF IFNG CD4
16 fungal meningitis 29.3 TNF IFNG CD4
17 multidrug-resistant tuberculosis 29.3 TNF IFNG CD4
18 peritonitis 29.3 TNF IFNG ADA
19 syphilis 29.3 TNF IFNG CD4
20 lymph node tuberculosis 29.3 TNF IFNG CD4
21 chorioretinitis 29.3 TNF IFNG CD4
22 allergic hypersensitivity disease 29.2 TNF IFNG CD4
23 extrapulmonary tuberculosis 29.2 TNF IFNG CD4 ADA
24 immune deficiency disease 29.1 TNF IFNG CD4 ADA
25 retinal vasculitis 29.1 TNF CD4
26 nervous system disease 29.0 TNF MMP9 IFNG CD4
27 abdominal tuberculosis 29.0 TNF IFNG CD4 ADA
28 crohn's disease 28.9 TNF IFNG CD4
29 sarcoidosis 1 28.9 TNF IFNG CD4 ADA
30 human immunodeficiency virus type 1 28.8 TNF IFNG CD4 ADA
31 hydrocephalus 10.5
32 spinal arachnoiditis 10.3
33 arachnoiditis 10.3
34 intracranial hypertension 10.3
35 parotitis 10.3 MMP9 CD4
36 tuberculous peritonitis 10.3 IFNG ADA
37 inflammatory spondylopathy 10.2
38 spondylitis 10.2
39 constrictive pericarditis 10.2 IFNG ADA
40 panophthalmitis 10.2 IFNG CD4
41 chronic graft versus host disease 10.2 IFNG CD4
42 purulent endophthalmitis 10.2 IFNG CD4
43 latent syphilis 10.2 IFNG CD4
44 penicilliosis 10.2 IFNG CD4
45 nickel allergic contact dermatitis 10.2 IFNG CD4
46 cysticercosis 10.2
47 adenosine deaminase deficiency 10.1 CD4 ADA
48 sporotrichosis 10.1 IFNG CD4
49 brain edema 10.1
50 glioma 10.1

Graphical network of the top 20 diseases related to Central Nervous System Tuberculosis:



Diseases related to Central Nervous System Tuberculosis

Symptoms & Phenotypes for Central Nervous System Tuberculosis

MGI Mouse Phenotypes related to Central Nervous System Tuberculosis:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.43 ADA CD4 IFNG MMP9 SIGIRR TNF
2 immune system MP:0005387 9.23 ADA CD4 IFNG MMP9 PIK3AP1 SIGIRR

Drugs & Therapeutics for Central Nervous System Tuberculosis

Drugs for Central Nervous System Tuberculosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Plasminogen

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Rapid Diagnostic Tests in Association With Clinical and Laboratory Predictors for the Diagnosis of Neglected Tropical Diseases in Patients With Neurological Disorders in Rural Hospitals of Bandundu,Democratic Republic of Congo Completed NCT01589289 Phase 3
2 Relation Between Plasma Soluble Urokinase Plasminogen Activator Receptor and Behçet's Disease . Not yet recruiting NCT04105439

Search NIH Clinical Center for Central Nervous System Tuberculosis

Cochrane evidence based reviews: tuberculoma, intracranial

Genetic Tests for Central Nervous System Tuberculosis

Anatomical Context for Central Nervous System Tuberculosis

The Foundational Model of Anatomy Ontology organs/tissues related to Central Nervous System Tuberculosis:

19
Brain, Spinal Cord

MalaCards organs/tissues related to Central Nervous System Tuberculosis:

40
Brain, Spinal Cord, Testes, Lung, Myeloid, T Cells, Medulla Oblongata

Publications for Central Nervous System Tuberculosis

Articles related to Central Nervous System Tuberculosis:

(show top 50) (show all 433)
# Title Authors PMID Year
1
Neuromyelitis optica spectrum disorder (NMOSD) with hypothalamic involvement and central nervous system tuberculosis: A case report. 61
32163749 2020
2
Extra-central nervous system tuberculosis in HIV-uninfected patients of tuberculous meningitis: A prospective evaluation. 61
32439354 2020
3
Clinical, Imaging, and Laboratory Characteristics of Adult Mexican Patients with Tuberculous Meningitis: A Retrospective Cohort Study. 61
32175711 2020
4
Presentation and outcome of patients with intracranial tuberculoma in a high HIV prevalence setting. 61
32127108 2020
5
18FDG-PET is sensitive tool for detection of extracranial tuberculous foci in central nervous system tuberculosis - Preliminary observations from a tertiary care center in northern India. 61
31816525 2020
6
Multi-spectral Pattern of Clinical Presentation and the Resultant Outcome in Central Nervous System Tuberculosis: A Single Center Study on the Ubiquitous Pathogen. 61
31994016 2020
7
Central nervous system tuberculoma with miliary tuberculosis in the elderly. 61
32055443 2020
8
Outcomes of Pediatric Central Nervous System Tuberculosis in California, 1993-2011. 61
30189047 2019
9
Uncommon case of Mycobacterium bovis brain abscess complicated by suppurative fistula, and review of the literature. 61
31713228 2019
10
Tuberculous encephalopathy without meningitis: A rare manifestation of disseminated tuberculosis. 61
31793515 2019
11
Delamanid Central Nervous System Pharmacokinetics in Tuberculous Meningitis in Rabbits and Humans. 61
31383662 2019
12
Stereotactic Aspiration in Management of Rare Case of Tuberculous Cerebellar Abscess. 61
31176834 2019
13
Bacterial Genotyping of Central Nervous System Tuberculosis in South Africa: Heterogenic Mycobacterium tuberculosis Infection and Predominance of Lineage 4. 61
31189579 2019
14
[Recurrent vomiting and headaches in a 26-year-old male patient]. 61
30980098 2019
15
Panhypopituitarism- An unusual presenation of tuberculous meningitis. 61
31439193 2019
16
Coexisting Spinal Intramedullary and Intracranial Tuberculomas in an Immunocompetent Child. 61
31649775 2019
17
[Disseminated tuberculosis revealed by obstructive and prerenal acute kidney failure]. 61
31097378 2019
18
Think central nervous system tuberculosis, also in low-risk children: a Danish nationwide survey. 61
30907215 2019
19
Changing trends of presentation of central nervous system tuberculosis: Relative prevalence of cranial and spinal tuberculosis and drug resistance patterns. 61
31347557 2019
20
Case report: an area postrema syndrome revealing a neuromyelitis optica spectrum disorder associated with central nervous system tuberculosis in a young Togolese (black African) woman. 61
30971218 2019
21
Central Nervous System Tuberculosis : Etiology, Clinical Manifestations and Neuroradiological Features. 61
30225516 2019
22
Matrix Metalloproteinases in Pulmonary and Central Nervous System Tuberculosis-A Review. 61
30889803 2019
23
Duration of anti-tuberculous therapy in children with persistent tuberculomas. 61
30671250 2019
24
Genome-Wide miRNA Analysis Identifies Potential Biomarkers in Distinguishing Tuberculous and Viral Meningitis. 61
31572691 2019
25
Practice Trends in Treating Central Nervous System Tuberculosis and Outcomes at a Tertiary Care Hospital: A Cohort Study of 244 Cases. 61
30692758 2019
26
Central nervous system tuberculosis reactivation following intravenous iron supplementation. 61
30860189 2019
27
Evaluation of cases of pediatric extrapulmonary tuberculosis: a single center experience. 61
31384143 2019
28
Spectrum of central nervous system tuberculosis: An experience from a large tertiary care institution of India. 61
30797283 2019
29
Bilateral primary optic neuropathy as the presenting manifestation of tuberculosis in an immunocompetent patient. 61
31367519 2019
30
Central Nervous System Tuberculosis - The Gray Area in Tuberculosis Treatment. 61
30765962 2019
31
Diagnosis and management of intracranial tuberculomas: about 2 cases and a review of the literature. 61
31762892 2019
32
Clinical Spectrum of Central Nervous System Tuberculosis and the Efficacy of Revised National Tuberculosis Control Program in its Management. 61
30765974 2019
33
A surgical case of cerebellar tuberculoma caused by a paradoxical reaction while on therapy for tuberculosis spondylitis. 61
31528497 2019
34
Symptomatic central nervous system tuberculoma, a case report in the United States and literature review. 61
31312602 2019
35
Contribution of brain imaging to the diagnosis of intracranial tuberculoma and other brain lesions in patients presenting with miliary tuberculosis. 61
30017477 2018
36
Impact of Mycobacterium tuberculosis complex lineages as a determinant of disease phenotypes from an immigrant rich moderate tuberculosis burden country. 61
30587190 2018
37
Evaluation of intracranial tuberculomas using diffusion-weighted imaging (DWI), magnetic resonance spectroscopy (MRS) and susceptibility weighted imaging (SWI). 61
29987985 2018
38
Atypical Clinical Presentation and Imaging Findings of Central Nervous System Tuberculosis. 61
30430973 2018
39
Clinical perspectives into the use of thalidomide for central nervous system tuberculosis. 61
29935038 2018
40
Radiological data in microbiologically confirmed central nervous system tuberculosis. 61
29906600 2018
41
Tuberculosis of the central nervous system in children. 61
29978252 2018
42
Relationship between malaria epidemiology and the human development index in Colombia and Latin America. 61
30246769 2018
43
Central nervous system tuberculosis following delayed and initially missed lung miliary tuberculosis: a case report. 61
30246772 2018
44
Isolated Tuberculoma Mimicking Foramen Magnum Meningioma in the Absence of Primary Tuberculosis: A Case Report. 61
30145853 2018
45
Management of Pediatric Posterior Circulation Aneurysms-12-Year Single-Institution Experience. 61
29778599 2018
46
Intraventricular Tuberculoma with Profound Visual Loss: A Case Report and Literature Review. 61
30123729 2018
47
Experimental animal models of central nervous system tuberculosis: A historical review. 61
29779764 2018
48
A rapid and simple resazurin assay to detect minimum inhibitory concentrations of first-line drugs for Mycobacterium tuberculosis isolated from cerebrospinal fluid. 61
28964954 2018
49
Central nervous system tuberculosis mimicking tentorium meningioma: a rare case. 61
29768567 2018
50
Neurocysticercosis versus disseminated intracranial tuberculoma. 61
29040731 2018

Variations for Central Nervous System Tuberculosis

Expression for Central Nervous System Tuberculosis

Search GEO for disease gene expression data for Central Nervous System Tuberculosis.

Pathways for Central Nervous System Tuberculosis

GO Terms for Central Nervous System Tuberculosis

Biological processes related to Central Nervous System Tuberculosis according to GeneCards Suite gene sharing:

(show all 15)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 9.62 TNF MMP9 IFNG CD4
2 positive regulation of T cell activation GO:0050870 9.55 CD4 ADA
3 positive regulation of osteoclast differentiation GO:0045672 9.54 TNF IFNG
4 positive regulation of amyloid-beta formation GO:1902004 9.52 TNF IFNG
5 embryonic digestive tract development GO:0048566 9.51 TNF ADA
6 positive regulation of calcium-mediated signaling GO:0050850 9.49 CD4 ADA
7 astrocyte activation GO:0048143 9.48 TNF IFNG
8 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.46 TNF IFNG
9 positive regulation of chemokine biosynthetic process GO:0045080 9.43 TNF IFNG
10 negative regulation of amyloid-beta clearance GO:1900222 9.4 TNF IFNG
11 positive regulation of interleukin-1 beta biosynthetic process GO:0050725 9.37 TNF IFNG
12 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.26 TNF IFNG
13 positive regulation of vitamin D biosynthetic process GO:0060557 9.16 TNF IFNG
14 positive regulation of nitrogen compound metabolic process GO:0051173 8.96 TNF IFNG
15 macrophage differentiation GO:0030225 8.8 MMP9 IFNG CD4

Sources for Central Nervous System Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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