MCID: CNT007
MIFTS: 45

Central Nervous System Tuberculosis

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Tuberculosis

MalaCards integrated aliases for Central Nervous System Tuberculosis:

Name: Central Nervous System Tuberculosis 12 15
Intracranial Tuberculoma 12 73
Tuberculosis of Meninges and Central Nervous System 12
Tuberculosis, Central Nervous System 73
Tuberculous Abscess of Brain 12
Tuberculoma, Intracranial 44
Tuberculoma of Brain 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1638
ICD9CM 35 013.2 013.20
MeSH 44 D016862
SNOMED-CT 68 40769007 416265003

Summaries for Central Nervous System Tuberculosis

Disease Ontology : 12 An extrapulmonary tuberculosis that results in formation of tuberculomas located in brain or located in spinal cord.

MalaCards based summary : Central Nervous System Tuberculosis, also known as intracranial tuberculoma, is related to cavernous sinus meningioma and autoimmune inner ear disease. An important gene associated with Central Nervous System Tuberculosis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Influenza A and Pathways in cancer. Affiliated tissues include brain or, brain and spinal cord, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

Related Diseases for Central Nervous System Tuberculosis

Diseases related to Central Nervous System Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 cavernous sinus meningioma 10.8 CD163 CD207
2 autoimmune inner ear disease 10.7 MMP9 TIMP1
3 diabetic foot ulcers 10.7 MMP9 TIMP1
4 necrobiosis lipoidica 10.6 CD163 GLI1
5 langerhans cell sarcoma 10.6 CD163 CD207
6 histiocytic and dendritic cell cancer 10.6 CD163 CD207
7 inner ear disease 10.5 GJB6 MMP9 TIMP1
8 keratocystic odontogenic tumor 10.5 GLI1 MMP9 SHH
9 type ii mixed cryoglobulinemia 10.4 FAS FASLG
10 lymphocytic gastritis 10.4 FAS FASLG
11 mid-dermal elastolysis 10.4 ELANE TIMP1
12 photokeratitis 10.4 CD163 FASLG MMP9
13 pulmonary emphysema 10.3 ELANE MMP9 TIMP1
14 chronic venous leg ulcers 10.3 FASLG MMP9 TIMP1
15 conjunctival nevus 10.2 MMP9 MUC5AC TIMP1
16 chronic follicular conjunctivitis 10.2 IL1B MMP9
17 gastric tubular adenocarcinoma 10.1 GLI1 MUC5AC SHH
18 acute myocarditis 10.1 FAS FASLG STAT1
19 scleritis 10.1 MMP9 SELE
20 lymphomatoid papulosis 10.0 FAS FASLG
21 kashin-beck disease 10.0 FAS IL1B
22 keratitis, hereditary 9.9 GJB6 IL1B MMP9
23 cryptogenic organizing pneumonia 9.9 MMP9 TIMP1
24 epstein-barr virus-associated gastric carcinoma 9.9 FAS FASLG MUC5AC
25 acquired immunodeficiency syndrome 9.9
26 miliary tuberculosis 9.9
27 pancreas adenocarcinoma 9.9 GLI1 MUC5AC SHH
28 appendicitis 9.8 IL1B MMP9 TIMP1
29 carotid artery disease 9.8 CD163 MMP9 SELE TIMP1
30 systemic lupus erythematosus 9.8
31 stroke, ischemic 9.8
32 arthritis 9.8
33 retinal vein occlusion 9.8
34 dementia 9.8
35 cerebritis 9.8
36 retinitis 9.8
37 lupus erythematosus 9.8
38 hypopituitarism 9.8
39 aneurysm 9.8
40 headache 9.8
41 periodontitis 9.7 IL1B MMP9 TIMP1
42 fibrosarcoma 9.7 MMP9 STAT1 TIMP1
43 chorioamnionitis 9.7 ELANE IL1B MMP9
44 gingivitis 9.7 ELANE IL1B MMP9
45 interstitial lung disease 9.7 IL1B MMP9 TIMP1
46 kawasaki disease 9.6 ELANE MMP9 SELE TIMP1
47 campylobacteriosis 9.6 IL1B STAT1
48 gingival disease 9.6 ELANE IL1B TIMP1
49 silicosis 9.6 FAS FASLG IL1B
50 pneumoconiosis 9.5 FAS FASLG IL1B

Graphical network of the top 20 diseases related to Central Nervous System Tuberculosis:



Diseases related to Central Nervous System Tuberculosis

Symptoms & Phenotypes for Central Nervous System Tuberculosis

GenomeRNAi Phenotypes related to Central Nervous System Tuberculosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 FAS FASLG MUC5AC SELE SHH STAT1

MGI Mouse Phenotypes related to Central Nervous System Tuberculosis:

46 (show all 15)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.37 FAS ARG1 CD163 FASLG CXCL10 ELANE
2 immune system MP:0005387 10.35 FAS ARG1 CD163 CD207 FASLG CXCL10
3 cardiovascular system MP:0005385 10.29 FAS CD163 CXCL10 FASLG GJB6 IL1B
4 hematopoietic system MP:0005397 10.29 ARG1 FAS CD163 CD207 CXCL10 FASLG
5 cellular MP:0005384 10.28 FAS CD163 CXCL10 FASLG MMP9 GLI1
6 mortality/aging MP:0010768 10.22 ARG1 FAS CXCL10 FASLG ELANE MMP9
7 digestive/alimentary MP:0005381 10.07 FAS FASLG MMP9 MUC5AC GLI1 STAT1
8 integument MP:0010771 10.06 FAS FASLG GJB6 MMP9 IL1B STAT1
9 nervous system MP:0003631 10.06 ARG1 FAS CXCL10 FASLG MMP9 GJB6
10 neoplasm MP:0002006 10.02 FAS FASLG ELANE GLI1 IL1B MMP9
11 limbs/digits/tail MP:0005371 9.98 FAS MMP9 GLI1 SCUBE2 STAT1 SHH
12 normal MP:0002873 9.86 ELANE ARG1 FAS FASLG GLI1 STAT1
13 respiratory system MP:0005388 9.76 FAS CD163 FASLG MMP9 GLI1 SELE
14 skeleton MP:0005390 9.61 FAS FASLG MMP9 POU3F3 SCUBE2 IL1B
15 vision/eye MP:0005391 9.23 FAS CD163 FASLG MMP9 MUC5AC STAT1

Drugs & Therapeutics for Central Nervous System Tuberculosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Completed NCT01589289 Phase 3

Search NIH Clinical Center for Central Nervous System Tuberculosis

Cochrane evidence based reviews: tuberculoma, intracranial

Genetic Tests for Central Nervous System Tuberculosis

Anatomical Context for Central Nervous System Tuberculosis

The Foundational Model of Anatomy Ontology organs/tissues related to Central Nervous System Tuberculosis:

19
Brain Or

MalaCards organs/tissues related to Central Nervous System Tuberculosis:

41
Brain, Spinal Cord, Testes, T Cells, Monocytes, Myeloid, Lymph Node

Publications for Central Nervous System Tuberculosis

Articles related to Central Nervous System Tuberculosis:

(show top 50) (show all 93)
# Title Authors Year
1
Radiological data in microbiologically confirmed central nervous system tuberculosis. ( 29906600 )
2018
2
Central nervous system tuberculosis mimicking tentorium meningioma: a rare case. ( 29768567 )
2018
3
Experimental animal models of central nervous system tuberculosis: A historical review. ( 29779764 )
2018
4
Clinical perspectives into the use of thalidomide for central nervous system tuberculosis. ( 29935038 )
2018
5
Central Nervous System Tuberculosis. ( 28281443 )
2017
6
Central nervous system Tuberculosis in a man from Cambodia with worsening headaches. ( 29026544 )
2017
7
Ruptured intracranial tuberculous aneurysm, a rare complication of central nervous system tuberculosis- A report and review of literature. ( 28488632 )
2017
8
Complex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosis. ( 28173836 )
2017
9
A scoring system to effectively evaluate central nervous system tuberculosis in patients with military tuberculosis. ( 28531173 )
2017
10
Myeloid and T Cell-Derived TNF Protects against Central Nervous System Tuberculosis. ( 28280495 )
2017
11
Nitric oxide in cerebrospinal fluid of central nervous system tuberculosis: correlations with culture, antibody response, and cell count. ( 28263476 )
2017
12
Correction: A scoring system to effectively evaluate central nervous system tuberculosis in patients with miliary tuberculosis. ( 28767710 )
2017
13
Central Nervous System Tuberculosis: An Imaging Perspective. ( 28283299 )
2017
14
Surface-modified gatifloxacin nanoparticles with potential for treating central nervous system tuberculosis. ( 28331318 )
2017
15
Factors Determining the Clinical Spectrum, Course and Response to Treatment, and Complications in Seronegative Patients with Central Nervous System Tuberculosis. ( 28479800 )
2017
16
Central Nervous System Tuberculosis in an Immigrant Child. ( 27231208 )
2016
17
Tuberculous ventriculitis: A rare complication of central nervous system tuberculosis. ( 27242238 )
2016
18
Immune reconstitution inflammatory syndrome in central nervous system tuberculosis. ( 27451593 )
2015
19
Immunoconfirmation of central nervous system tuberculosis by blotting: A study of 300 cases. ( 26972880 )
2015
20
Microglia are crucial regulators of neuro-immunity during central nervous system tuberculosis. ( 26041993 )
2015
21
Central nervous system tuberculosis reviewed. ( 26338350 )
2015
22
Central nervous system tuberculosis: an imaging-focused review of a reemerging disease. ( 25653877 )
2015
23
Risk Factors for Central Nervous System Tuberculosis. ( 26438712 )
2015
24
Does non-central nervous system tuberculosis increase the risk of ischemic stroke? A population-based propensity score-matched follow-up study. ( 25048551 )
2014
25
Cerebral infarction and tuberculoma in central nervous system tuberculosis: frequency and prognostic implications. ( 24623792 )
2014
26
Central nervous system tuberculosis. ( 24887691 )
2014
27
Central nervous system tuberculosis. ( 25241567 )
2014
28
A rare case of central nervous system tuberculosis. ( 25478256 )
2014
29
Characteristics of central nervous system tuberculosis in a low-incidence country: a series of 20 cases and a review of the literature. ( 24451103 )
2014
30
HIV-associated central nervous system tuberculosis. ( 24715493 )
2014
31
Central nervous system tuberculosis presenting as branch retinal vein occlusion. ( 22738141 )
2013
32
Central Nervous System Tuberculosis: Challenges and Advances in Diagnosis and Treatment. ( 24122343 )
2013
33
Central nervous system tuberculosis: a disease from Papua New Guinea in North Queensland. ( 23480051 )
2013
34
The dual face of central nervous system tuberculosis: a new Janus Bifrons? ( 23305698 )
2013
35
Central nervous system tuberculosis: pathophysiology and imaging findings. ( 23122262 )
2012
36
A life-threatening central nervous system-tuberculosis inflammatory reaction nonresponsive to corticosteroids and successfully controlled by infliximab in a young patient with a variant of juvenile idiopathic arthritis. ( 22647865 )
2012
37
Role of Mycobacterium tuberculosis pknD in the pathogenesis of central nervous system tuberculosis. ( 22243650 )
2012
38
Central nervous system tuberculosis in non-HIV-positive children: a single-center, 6 year experience. ( 22095412 )
2012
39
The PCR-Based Diagnosis of Central Nervous System Tuberculosis: Up to Date. ( 22666577 )
2012
40
Central nervous system tuberculosis: mimicking neuropsychiatric systemic lupus erythematosus. ( 22367698 )
2012
41
Multi-drug-resistant central nervous system tuberculosis. ( 22626692 )
2012
42
Central nervous system tuberculosis: a forgotten diagnosis. ( 22735252 )
2012
43
Ophthalmic manifestations of central nervous system tuberculosis--two case reports. ( 22533169 )
2011
44
Lymphocyte apoptosis in children with central nervous system tuberculosis: a case control study. ( 22111973 )
2011
45
The many faces of central nervous system tuberculosis. ( 21825249 )
2011
46
Central nervous system tuberculosis. ( 22032500 )
2011
47
Central nervous system tuberculosis. ( 21572867 )
2011
48
Ventriculitis caused by Aspergillus fumigatus in a child with central nervous system tuberculosis. ( 20701684 )
2011
49
Treatment of central nervous system tuberculosis infections and neurological complications of tuberculosis treatment. ( 21834764 )
2011
50
Hypopituitarism as unusual sequelae to central nervous system tuberculosis. ( 22029037 )
2011

Variations for Central Nervous System Tuberculosis

Expression for Central Nervous System Tuberculosis

Search GEO for disease gene expression data for Central Nervous System Tuberculosis.

Pathways for Central Nervous System Tuberculosis

Pathways related to Central Nervous System Tuberculosis according to GeneCards Suite gene sharing:

(show all 23)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
12.65 CXCL10 FAS FASLG IL1B STAT1
2 12.57 FAS FASLG GLI1 MMP9 SHH STAT1
3
Show member pathways
12.42 FAS FASLG MMP9 STAT1
4 12.37 CXCL10 FAS FASLG IL1B STAT1
5
Show member pathways
12.19 CXCL10 IL1B MMP9 MUC5AC
6 12.13 FAS FASLG MMP9 SHH
7
Show member pathways
12.05 FAS FASLG IL1B STAT1
8
Show member pathways
11.87 CXCL10 FAS FASLG IL1B STAT1
9
Show member pathways
11.83 FASLG IL1B STAT1
10 11.78 ARG1 CXCL10 IL1B MMP9
11 11.76 IL1B SELE STAT1
12
Show member pathways
11.76 ELANE MMP9 TIMP1
13 11.62 CD163 CD207 IL1B
14 11.61 FASLG IL1B MMP9 STAT1 TIMP1
15 11.52 IL1B MMP9 TIMP1
16
Show member pathways
11.51 IL1B MMP9 SELE
17 11.39 CXCL10 FAS IL1B MMP9 SELE
18 11.36 CXCL10 IL1B TIMP1
19 11.24 ELANE MMP9 SELE
20 11.18 CXCL10 IL1B STAT1
21 10.9 IL1B MMP9 TIMP1
22 10.89 STAT1 TIMP1
23 10.47 FAS FASLG IL1B SELE

GO Terms for Central Nervous System Tuberculosis

Cellular components related to Central Nervous System Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.73 ARG1 CD163 CXCL10 ELANE FAS FASLG
2 cell surface GO:0009986 9.65 ELANE FAS FASLG SCUBE2 SHH
3 membrane raft GO:0045121 9.46 FAS FASLG SELE SHH
4 extracellular space GO:0005615 9.36 ARG1 CXCL10 ELANE FASLG IL1B MMP9

Biological processes related to Central Nervous System Tuberculosis according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.98 GLI1 IL1B POU3F3 SHH STAT1
2 negative regulation of apoptotic process GO:0043066 9.96 FAS MMP9 POU3F3 SHH TIMP1
3 cell-cell signaling GO:0007267 9.91 CXCL10 FASLG IL1B SHH
4 regulation of signaling receptor activity GO:0010469 9.88 CXCL10 FASLG IL1B SHH TIMP1
5 tumor necrosis factor-mediated signaling pathway GO:0033209 9.8 FAS FASLG STAT1
6 leukocyte migration GO:0050900 9.8 ELANE IL1B MMP9 SELE
7 inflammatory response GO:0006954 9.8 CD163 CXCL10 FAS IL1B SELE
8 negative regulation of angiogenesis GO:0016525 9.78 CXCL10 FASLG STAT1
9 lung development GO:0030324 9.74 ARG1 GLI1 SHH
10 apoptotic signaling pathway GO:0097190 9.71 FAS FASLG SHH
11 extracellular matrix disassembly GO:0022617 9.7 ELANE MMP9 TIMP1
12 response to peptide hormone GO:0043434 9.63 ARG1 STAT1 TIMP1
13 cytokine-mediated signaling pathway GO:0019221 9.63 CXCL10 FASLG IL1B MMP9 STAT1 TIMP1
14 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.6 FAS FASLG
15 prostate gland development GO:0030850 9.59 GLI1 SHH
16 digestive tract morphogenesis GO:0048546 9.58 GLI1 SHH
17 positive regulation of cell proliferation GO:0008284 9.56 CXCL10 FASLG GLI1 IL1B POU3F3 SHH
18 activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway GO:0097296 9.55 FAS FASLG
19 leukocyte migration involved in inflammatory response GO:0002523 9.51 ELANE SELE
20 necroptotic signaling pathway GO:0097527 9.43 FAS FASLG
21 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 9.37 GLI1 SHH
22 metanephric mesenchymal cell proliferation involved in metanephros development GO:0072136 9.32 SHH STAT1
23 ventral midline development GO:0007418 9.26 GLI1 SHH
24 response to lipopolysaccharide GO:0032496 9.23 ARG1 CXCL10 ELANE FAS FASLG GJB6
25 positive regulation of transcription by RNA polymerase II GO:0045944 10.09 CXCL10 GLI1 IL1B POU3F3 SHH STAT1

Molecular functions related to Central Nervous System Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.92 CXCL10 FASLG IL1B TIMP1

Sources for Central Nervous System Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
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30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
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36 IUPHAR
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45 MESH via Orphanet
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49 NCI
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51 NDF-RT
54 NINDS
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57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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