MCID: CNT007
MIFTS: 31

Central Nervous System Tuberculosis

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Tuberculosis

MalaCards integrated aliases for Central Nervous System Tuberculosis:

Name: Central Nervous System Tuberculosis 12 15 17
Tuberculosis, Central Nervous System 44 72
Intracranial Tuberculoma 12 72
Tuberculosis of Meninges and Central Nervous System 12
Tuberculous Abscess of Brain 12
Tuberculoma, Intracranial 44
Tuberculoma of Brain 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1638
ICD9CM 35 013.2 013.20
SNOMED-CT 68 40769007
UMLS 72 C0085388 C0275904

Summaries for Central Nervous System Tuberculosis

Disease Ontology : 12 An extrapulmonary tuberculosis that results in formation of tuberculomas located in brain or located in spinal cord.

MalaCards based summary : Central Nervous System Tuberculosis, also known as tuberculosis, central nervous system, is related to cerebrovascular disease and tuberculous meningitis. An important gene associated with Central Nervous System Tuberculosis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are CXCR4-mediated signaling events and Dendritic Cells Developmental Lineage Pathway. Affiliated tissues include brain, spinal cord and brain.

Related Diseases for Central Nervous System Tuberculosis

Diseases related to Central Nervous System Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 164)
# Related Disease Score Top Affiliating Genes
1 cerebrovascular disease 28.8 MTR MMP9
2 tuberculous meningitis 10.7
3 mycobacterium tuberculosis 1 10.6
4 hydrocephalus 10.5
5 congenital hydrocephalus 10.5
6 spinal arachnoiditis 10.3
7 arachnoiditis 10.3
8 miliary tuberculosis 10.3
9 intracranial hypertension 10.3
10 meningitis 10.3
11 inflammatory spondylopathy 10.2
12 spondylitis 10.2
13 chronic meningitis 10.2
14 pulmonary tuberculosis 10.2
15 acquired immunodeficiency syndrome 10.2
16 cysticercosis 10.2
17 brain edema 10.1
18 glioma 10.1
19 seizure disorder 10.1
20 glial tumor 10.1
21 immune deficiency disease 10.0
22 extrapulmonary tuberculosis 10.0
23 meningoencephalitis 10.0
24 uveitis 10.0
25 hypothyroidism 10.0
26 communicating hydrocephalus 10.0
27 cranial nerve palsy 10.0
28 vasculitis 10.0
29 spinal cord infarction 10.0
30 hydrops, lactic acidosis, and sideroblastic anemia 10.0
31 visual epilepsy 10.0
32 lymphadenitis 10.0
33 epilepsy 10.0
34 toxoplasmosis 10.0
35 paresthesia 10.0
36 spondyloarthropathy 1 9.9
37 systemic lupus erythematosus 9.9
38 multinucleated neurons, anhydramnios, renal dysplasia, cerebellar hypoplasia, and hydranencephaly 9.9
39 ocular motor apraxia 9.9
40 ataxia and polyneuropathy, adult-onset 9.9
41 stroke, ischemic 9.9
42 aceruloplasminemia 9.9
43 meningioma, radiation-induced 9.9
44 meningioma, familial 9.9
45 hyperprolactinemia 9.9
46 la crosse encephalitis 9.9
47 inflammatory bowel disease 9.9
48 vitamin b12 deficiency 9.9
49 aphasia 9.9
50 cardiac arrest 9.9

Graphical network of the top 20 diseases related to Central Nervous System Tuberculosis:



Diseases related to Central Nervous System Tuberculosis

Symptoms & Phenotypes for Central Nervous System Tuberculosis

Drugs & Therapeutics for Central Nervous System Tuberculosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Rapid Diagnostic Tests in Association With Clinical and Laboratory Predictors for the Diagnosis of Neglected Tropical Diseases in Patients With Neurological Disorders in Rural Hospitals of Bandundu,Democratic Republic of Congo Completed NCT01589289 Phase 3

Search NIH Clinical Center for Central Nervous System Tuberculosis

Cochrane evidence based reviews: tuberculoma, intracranial

Genetic Tests for Central Nervous System Tuberculosis

Anatomical Context for Central Nervous System Tuberculosis

The Foundational Model of Anatomy Ontology organs/tissues related to Central Nervous System Tuberculosis:

19
Brain, Spinal Cord

MalaCards organs/tissues related to Central Nervous System Tuberculosis:

41
Brain, Spinal Cord, Testes, Lung, T Cells, Medulla Oblongata, Lymph Node

Publications for Central Nervous System Tuberculosis

Articles related to Central Nervous System Tuberculosis:

(show top 50) (show all 237)
# Title Authors PMID Year
1
Stereotactic Aspiration in Management of Rare Case of Tuberculous Cerebellar Abscess. 38
31176834 2019
2
Bacterial Genotyping of Central Nervous System Tuberculosis in South Africa: Heterogenic Mycobacterium tuberculosis Infection and Predominance of Lineage 4. 38
31189579 2019
3
Delamanid Central Nervous System Pharmacokinetics in Tuberculous Meningitis in Rabbits and Humans. 38
31383662 2019
4
[Recurrent vomiting and headaches in a 26-year-old male patient]. 38
30980098 2019
5
Changing trends of presentation of central nervous system tuberculosis: Relative prevalence of cranial and spinal tuberculosis and drug resistance patterns. 38
31347557 2019
6
Think central nervous system tuberculosis, also in low-risk children: a Danish nationwide survey. 38
30907215 2019
7
Case report: an area postrema syndrome revealing a neuromyelitis optica spectrum disorder associated with central nervous system tuberculosis in a young Togolese (black African) woman. 38
30971218 2019
8
Matrix Metalloproteinases in Pulmonary and Central Nervous System Tuberculosis-A Review. 38
30889803 2019
9
Central Nervous System Tuberculosis : Etiology, Clinical Manifestations and Neuroradiological Features. 38
30225516 2019
10
Central nervous system tuberculosis reactivation following intravenous iron supplementation. 38
30860189 2019
11
Evaluation of cases of pediatric extrapulmonary tuberculosis: a single center experience. 38
31384143 2019
12
Spectrum of central nervous system tuberculosis: An experience from a large tertiary care institution of India. 38
30797283 2019
13
Practice Trends in Treating Central Nervous System Tuberculosis and Outcomes at a Tertiary Care Hospital: A Cohort Study of 244 Cases. 38
30692758 2019
14
Bilateral primary optic neuropathy as the presenting manifestation of tuberculosis in an immunocompetent patient. 38
31367519 2019
15
Clinical Spectrum of Central Nervous System Tuberculosis and the Efficacy of Revised National Tuberculosis Control Program in its Management. 38
30765974 2019
16
Central Nervous System Tuberculosis - The Gray Area in Tuberculosis Treatment. 38
30765962 2019
17
Duration of anti-tuberculous therapy in children with persistent tuberculomas. 38
30671250 2019
18
Impact of Mycobacterium tuberculosis complex lineages as a determinant of disease phenotypes from an immigrant rich moderate tuberculosis burden country. 38
30587190 2018
19
Evaluation of intracranial tuberculomas using diffusion-weighted imaging (DWI), magnetic resonance spectroscopy (MRS) and susceptibility weighted imaging (SWI). 38
29987985 2018
20
Clinical perspectives into the use of thalidomide for central nervous system tuberculosis. 38
29935038 2018
21
Atypical Clinical Presentation and Imaging Findings of Central Nervous System Tuberculosis. 38
30430973 2018
22
Radiological data in microbiologically confirmed central nervous system tuberculosis. 38
29906600 2018
23
Tuberculosis of the central nervous system in children. 38
29978252 2018
24
Central nervous system tuberculosis following delayed and initially missed lung miliary tuberculosis: a case report. 38
30246772 2018
25
Isolated Tuberculoma Mimicking Foramen Magnum Meningioma in the Absence of Primary Tuberculosis: A Case Report. 38
30145853 2018
26
Outcomes of Pediatric Central Nervous System Tuberculosis in California, 1993-2011. 38
30189047 2018
27
Management of Pediatric Posterior Circulation Aneurysms-12-Year Single-Institution Experience. 38
29778599 2018
28
Experimental animal models of central nervous system tuberculosis: A historical review. 38
29779764 2018
29
A rapid and simple resazurin assay to detect minimum inhibitory concentrations of first-line drugs for Mycobacterium tuberculosis isolated from cerebrospinal fluid. 38
28964954 2018
30
Central nervous system tuberculosis mimicking tentorium meningioma: a rare case. 38
29768567 2018
31
Study of Central Nervous System Tuberculosis. 38
30341844 2018
32
Successful rapid oral desensitization for dual hypersensitivity to isoniazid and rifampin while treating central nervous system tuberculosis. 38
30559942 2018
33
An Atypical Presentation of Tuberculomas in an Immunocompetent Host. 38
30186886 2018
34
[Extramedullary intradural tuberculosis: a case report and review of the literature]. 38
29251339 2018
35
Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis. 38
29167512 2017
36
Central nervous system Tuberculosis in a man from Cambodia with worsening headaches. 38
29026544 2017
37
Brain Tuberculoma: A Case Report and Literature Review. 38
28806025 2017
38
Choroid plexus tuberculoma. Diagnosis, management and role of endoscopy. 38
28678217 2017
39
Intracranial en-plaque tuberculoma impersonating en-plaque meningioma: Case report and brief review of literature. 38
28761548 2017
40
Tuberculous meningoencephalitis associated with brain tuberculomas during pregnancy: a case report. 38
28659187 2017
41
Old age and hydrocephalus are associated with poor prognosis in patients with tuberculous meningitis: A retrospective study in a Chinese adult population. 38
28658161 2017
42
Central Nervous System Tuberculosis: An Imaging Perspective. 38
28283299 2017
43
Ruptured intracranial tuberculous aneurysm, a rare complication of central nervous system tuberculosis- A report and review of literature. 38
28488632 2017
44
Factors Determining the Clinical Spectrum, Course and Response to Treatment, and Complications in Seronegative Patients with Central Nervous System Tuberculosis. 38
28479800 2017
45
Comparative Diagnostic Utility of IS6110 PCR Assay in CSF and Peripheral Blood Samples of Tuberculous Meningitis Patients: A Pilot Study from Central India. 38
28571129 2017
46
Clinical and radiological spectrum of intracranial tuberculosis: A hospital based study in Northeast India. 38
28410693 2017
47
Cerebrospinal fluid metabolomic profiling in tuberculous and viral meningitis: Screening potential markers for differential diagnosis. 38
28063937 2017
48
Central Nervous System Tuberculosis. 38
28281443 2017
49
Nitric oxide in cerebrospinal fluid of central nervous system tuberculosis: correlations with culture, antibody response, and cell count. 38
28263476 2017
50
Complex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosis. 38
28173836 2017

Variations for Central Nervous System Tuberculosis

Expression for Central Nervous System Tuberculosis

Search GEO for disease gene expression data for Central Nervous System Tuberculosis.

Pathways for Central Nervous System Tuberculosis

Pathways related to Central Nervous System Tuberculosis according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.84 MMP9 CD4
2 10.49 CD4 CD207

GO Terms for Central Nervous System Tuberculosis

Biological processes related to Central Nervous System Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of protein phosphorylation GO:0001934 8.62 MMP9 CD4

Molecular functions related to Central Nervous System Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 zinc ion binding GO:0008270 8.8 MTR MMP9 CD4

Sources for Central Nervous System Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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