MCID: CNT007
MIFTS: 45

Central Nervous System Tuberculosis

Categories: Infectious diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Tuberculosis

MalaCards integrated aliases for Central Nervous System Tuberculosis:

Name: Central Nervous System Tuberculosis 12 15
Tuberculosis, Central Nervous System 44 73
Intracranial Tuberculoma 12 73
Tuberculosis of Meninges and Central Nervous System 12
Tuberculous Abscess of Brain 12
Tuberculoma, Intracranial 44
Tuberculoma of Brain 12

Classifications:



External Ids:

Disease Ontology 12 DOID:1638
ICD9CM 35 013.2 013.20
SNOMED-CT 68 40769007

Summaries for Central Nervous System Tuberculosis

Disease Ontology : 12 An extrapulmonary tuberculosis that results in formation of tuberculomas located in brain or located in spinal cord.

MalaCards based summary : Central Nervous System Tuberculosis, also known as tuberculosis, central nervous system, is related to systemic lupus erythematosus and meningitis. An important gene associated with Central Nervous System Tuberculosis is MMP9 (Matrix Metallopeptidase 9), and among its related pathways/superpathways are Innate Immune System and Toll-like Receptor Signaling Pathway. Affiliated tissues include brain, spinal cord and lung, and related phenotypes are Reduced mammosphere formation and homeostasis/metabolism

Related Diseases for Central Nervous System Tuberculosis

Diseases related to Central Nervous System Tuberculosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 95)
# Related Disease Score Top Affiliating Genes
1 systemic lupus erythematosus 28.5 CXCL10 ELANE FAS FASLG IL1B SELE
2 meningitis 10.3
3 tuberculous meningitis 10.3
4 cavernous sinus meningioma 10.3 CD163 CD207
5 autoimmune inner ear disease 10.2 MMP9 TIMP1
6 langerhans cell sarcoma 10.2 CD163 CD207
7 necrobiosis lipoidica 10.2 CD163 GLI1
8 mycobacterium tuberculosis 1 10.2
9 non-langerhans-cell histiocytosis 10.2 CD163 CD207
10 inner ear disease 10.2 GJB6 MMP9 TIMP1
11 fungal keratitis 10.2 MMP9 TIMP1
12 keratocystic odontogenic tumor 10.1 GLI1 MMP9 SHH
13 type ii mixed cryoglobulinemia 10.1 FAS FASLG
14 mid-dermal elastolysis 10.1 ELANE TIMP1
15 histiocytic and dendritic cell cancer 10.1 CD163 CD207
16 lymphocytic gastritis 10.1 FAS FASLG
17 miliary tuberculosis 10.1
18 photokeratitis 10.1 CD163 FASLG MMP9
19 pulmonary emphysema 10.1 ELANE MMP9 TIMP1
20 conjunctival nevus 10.1 MMP9 MUC5AC TIMP1
21 chronic venous leg ulcers 10.1 FAS FASLG TIMP1
22 chronic follicular conjunctivitis 10.1 IL1B MMP9
23 scleritis 10.1 MMP9 SELE
24 acute myocarditis 10.0 FAS FASLG STAT1
25 acquired immunodeficiency syndrome 10.0
26 gastric tubular adenocarcinoma 10.0 GLI1 MUC5AC SHH
27 carotid artery disease 10.0 MMP9 SELE TIMP1
28 lymphomatoid papulosis 10.0 FAS FASLG
29 hydrocephalus 10.0
30 cysticercosis 10.0
31 cryptogenic organizing pneumonia 10.0 MMP9 TIMP1
32 keratitis, hereditary 10.0 GJB6 IL1B MMP9
33 epstein-barr virus-associated gastric carcinoma 10.0 FAS FASLG MUC5AC
34 pulmonary fibrosis 10.0 IL1B MMP9 TIMP1
35 kashin-beck disease 10.0 FAS IL1B
36 pancreas adenocarcinoma 10.0 GLI1 MMP9 MUC5AC SHH
37 appendicitis 10.0 IL1B MMP9 TIMP1
38 autoimmune vasculitis 9.9 ELANE IL1B
39 periodontitis 9.9 IL1B MMP9 TIMP1
40 fibrosarcoma 9.9 MMP9 STAT1 TIMP1
41 chorioamnionitis 9.9 ELANE IL1B MMP9
42 interstitial lung disease 9.9 IL1B MMP9 TIMP1
43 gingivitis 9.9 ELANE IL1B MMP9
44 campylobacteriosis 9.9 IL1B STAT1
45 kawasaki disease 9.9 ELANE MMP9 SELE TIMP1
46 gingival disease 9.9 ELANE IL1B TIMP1
47 stroke, ischemic 9.9
48 arthritis 9.9
49 retinal vein occlusion 9.9
50 dementia 9.9

Graphical network of the top 20 diseases related to Central Nervous System Tuberculosis:



Diseases related to Central Nervous System Tuberculosis

Symptoms & Phenotypes for Central Nervous System Tuberculosis

GenomeRNAi Phenotypes related to Central Nervous System Tuberculosis according to GeneCards Suite gene sharing:

26
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Reduced mammosphere formation GR00396-S 9.17 FAS FASLG MUC5AC SELE SHH STAT1

MGI Mouse Phenotypes related to Central Nervous System Tuberculosis:

46 (show all 16)
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 10.39 ARG1 CD163 CXCL10 ELANE FAS FASLG
2 immune system MP:0005387 10.37 ARG1 CD163 CD207 CXCL10 ELANE FAS
3 cardiovascular system MP:0005385 10.3 CD163 CXCL10 FAS FASLG GJB6 IL1B
4 hematopoietic system MP:0005397 10.3 ARG1 CD163 CD207 CXCL10 ELANE FAS
5 cellular MP:0005384 10.29 CD163 CXCL10 FAS FASLG GLI1 MMP9
6 mortality/aging MP:0010768 10.22 ARG1 CXCL10 ELANE FAS FASLG GLI1
7 digestive/alimentary MP:0005381 10.08 FAS FASLG GLI1 MMP9 MUC5AC SHH
8 integument MP:0010771 10.08 FAS FASLG GJB6 IL1B MMP9 SELE
9 nervous system MP:0003631 10.06 ARG1 CXCL10 FAS FASLG GJB6 GLI1
10 neoplasm MP:0002006 10.02 ELANE FAS FASLG GLI1 IL1B MMP9
11 limbs/digits/tail MP:0005371 10 FAS GLI1 MMP9 SCUBE2 SHH STAT1
12 liver/biliary system MP:0005370 9.98 ARG1 CD207 FAS FASLG SELE SHH
13 normal MP:0002873 9.86 ARG1 ELANE FAS FASLG GLI1 SELE
14 respiratory system MP:0005388 9.81 CD163 CD207 FAS FASLG GLI1 MMP9
15 skeleton MP:0005390 9.61 FAS FASLG IL1B MMP9 POU3F3 SCUBE2
16 vision/eye MP:0005391 9.23 CD163 FAS FASLG MMP9 MUC5AC SELE

Drugs & Therapeutics for Central Nervous System Tuberculosis

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Rapid Diagnostic Tests and Clinical/Laboratory Predictors of Tropical Diseases in Neurological Disorders in DRC Completed NCT01589289 Phase 3

Search NIH Clinical Center for Central Nervous System Tuberculosis

Cochrane evidence based reviews: tuberculoma, intracranial

Genetic Tests for Central Nervous System Tuberculosis

Anatomical Context for Central Nervous System Tuberculosis

MalaCards organs/tissues related to Central Nervous System Tuberculosis:

41
Brain, Spinal Cord, Lung, Skin, Bone, Pancreas, Thyroid

The Foundational Model of Anatomy Ontology organs/tissues related to Central Nervous System Tuberculosis:

19
Brain Or

Publications for Central Nervous System Tuberculosis

Articles related to Central Nervous System Tuberculosis:

(show top 50) (show all 98)
# Title Authors Year
1
Radiological data in microbiologically confirmed central nervous system tuberculosis. ( 29906600 )
2018
2
Central nervous system tuberculosis mimicking tentorium meningioma: a rare case. ( 29768567 )
2018
3
Experimental animal models of central nervous system tuberculosis: A historical review. ( 29779764 )
2018
4
Clinical perspectives into the use of thalidomide for central nervous system tuberculosis. ( 29935038 )
2018
5
Outcomes of Pediatric Central Nervous System Tuberculosis in California, 1993-2011. ( 30189047 )
2018
6
Central Nervous System Tuberculosis : Etiology, Clinical Manifestations and Neuroradiological Features. ( 30225516 )
2018
7
Central nervous system tuberculosis following delayed and initially missed lung miliary tuberculosis: a case report. ( 30246772 )
2018
8
Study of Central Nervous System Tuberculosis. ( 30341844 )
2018
9
Atypical Clinical Presentation and Imaging Findings of Central Nervous System Tuberculosis. ( 30430973 )
2018
10
Central Nervous System Tuberculosis. ( 28281443 )
2017
11
Central nervous system Tuberculosis in a man from Cambodia with worsening headaches. ( 29026544 )
2017
12
Ruptured intracranial tuberculous aneurysm, a rare complication of central nervous system tuberculosis- A report and review of literature. ( 28488632 )
2017
13
Complex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosis. ( 28173836 )
2017
14
A scoring system to effectively evaluate central nervous system tuberculosis in patients with military tuberculosis. ( 28531173 )
2017
15
Myeloid and T Cell-Derived TNF Protects against Central Nervous System Tuberculosis. ( 28280495 )
2017
16
Nitric oxide in cerebrospinal fluid of central nervous system tuberculosis: correlations with culture, antibody response, and cell count. ( 28263476 )
2017
17
Correction: A scoring system to effectively evaluate central nervous system tuberculosis in patients with miliary tuberculosis. ( 28767710 )
2017
18
Central Nervous System Tuberculosis: An Imaging Perspective. ( 28283299 )
2017
19
Surface-modified gatifloxacin nanoparticles with potential for treating central nervous system tuberculosis. ( 28331318 )
2017
20
Factors Determining the Clinical Spectrum, Course and Response to Treatment, and Complications in Seronegative Patients with Central Nervous System Tuberculosis. ( 28479800 )
2017
21
Central Nervous System Tuberculosis in an Immigrant Child. ( 27231208 )
2016
22
Tuberculous ventriculitis: A rare complication of central nervous system tuberculosis. ( 27242238 )
2016
23
Immune reconstitution inflammatory syndrome in central nervous system tuberculosis. ( 27451593 )
2015
24
Immunoconfirmation of central nervous system tuberculosis by blotting: A study of 300 cases. ( 26972880 )
2015
25
Microglia are crucial regulators of neuro-immunity during central nervous system tuberculosis. ( 26041993 )
2015
26
Central nervous system tuberculosis reviewed. ( 26338350 )
2015
27
Central nervous system tuberculosis: an imaging-focused review of a reemerging disease. ( 25653877 )
2015
28
Risk Factors for Central Nervous System Tuberculosis. ( 26438712 )
2015
29
Does non-central nervous system tuberculosis increase the risk of ischemic stroke? A population-based propensity score-matched follow-up study. ( 25048551 )
2014
30
Cerebral infarction and tuberculoma in central nervous system tuberculosis: frequency and prognostic implications. ( 24623792 )
2014
31
Central nervous system tuberculosis. ( 24887691 )
2014
32
Central nervous system tuberculosis. ( 25241567 )
2014
33
A rare case of central nervous system tuberculosis. ( 25478256 )
2014
34
Characteristics of central nervous system tuberculosis in a low-incidence country: a series of 20 cases and a review of the literature. ( 24451103 )
2014
35
HIV-associated central nervous system tuberculosis. ( 24715493 )
2014
36
Central nervous system tuberculosis presenting as branch retinal vein occlusion. ( 22738141 )
2013
37
Central Nervous System Tuberculosis: Challenges and Advances in Diagnosis and Treatment. ( 24122343 )
2013
38
Central nervous system tuberculosis: a disease from Papua New Guinea in North Queensland. ( 23480051 )
2013
39
The dual face of central nervous system tuberculosis: a new Janus Bifrons? ( 23305698 )
2013
40
Central nervous system tuberculosis: pathophysiology and imaging findings. ( 23122262 )
2012
41
A life-threatening central nervous system-tuberculosis inflammatory reaction nonresponsive to corticosteroids and successfully controlled by infliximab in a young patient with a variant of juvenile idiopathic arthritis. ( 22647865 )
2012
42
Role of Mycobacterium tuberculosis pknD in the pathogenesis of central nervous system tuberculosis. ( 22243650 )
2012
43
Central nervous system tuberculosis in non-HIV-positive children: a single-center, 6 year experience. ( 22095412 )
2012
44
The PCR-Based Diagnosis of Central Nervous System Tuberculosis: Up to Date. ( 22666577 )
2012
45
Central nervous system tuberculosis: mimicking neuropsychiatric systemic lupus erythematosus. ( 22367698 )
2012
46
Multi-drug-resistant central nervous system tuberculosis. ( 22626692 )
2012
47
Central nervous system tuberculosis: a forgotten diagnosis. ( 22735252 )
2012
48
Ophthalmic manifestations of central nervous system tuberculosis--two case reports. ( 22533169 )
2011
49
Lymphocyte apoptosis in children with central nervous system tuberculosis: a case control study. ( 22111973 )
2011
50
The many faces of central nervous system tuberculosis. ( 21825249 )
2011

Variations for Central Nervous System Tuberculosis

Expression for Central Nervous System Tuberculosis

Search GEO for disease gene expression data for Central Nervous System Tuberculosis.

Pathways for Central Nervous System Tuberculosis

Pathways related to Central Nervous System Tuberculosis according to GeneCards Suite gene sharing:

(show all 25)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.91 ARG1 CD207 CXCL10 ELANE FASLG IL1B
2
Show member pathways
12.87 CXCL10 FAS FASLG IL1B STAT1
3
Show member pathways
12.66 CXCL10 FAS FASLG IL1B STAT1
4 12.6 FAS FASLG GLI1 MMP9 SHH STAT1
5 12.39 CXCL10 FAS FASLG IL1B STAT1
6
Show member pathways
12.2 CXCL10 IL1B MMP9 MUC5AC
7 12.14 FAS FASLG MMP9 SHH
8
Show member pathways
12.06 FAS FASLG IL1B STAT1
9
Show member pathways
11.94 CXCL10 FAS FASLG IL1B STAT1
10
Show member pathways
11.83 FASLG IL1B STAT1
11 11.81 ARG1 CXCL10 IL1B MMP9
12 11.77 IL1B SELE STAT1
13
Show member pathways
11.76 ELANE MMP9 TIMP1
14 11.71 FASLG IL1B MMP9 STAT1 TIMP1
15 11.63 CD163 CD207 IL1B
16 11.6 CXCL10 FAS IL1B MMP9 SELE
17 11.53 IL1B MMP9 TIMP1
18
Show member pathways
11.52 IL1B MMP9 SELE
19 11.38 CXCL10 IL1B TIMP1
20 11.26 ELANE MMP9 SELE
21 11.2 CXCL10 IL1B STAT1
22 10.94 IL1B MMP9 TIMP1
23 10.89 STAT1 TIMP1
24 10.87 ARG1 CD163 CXCL10 IL1B MMP9
25 10.8 FAS FASLG IL1B SELE

GO Terms for Central Nervous System Tuberculosis

Cellular components related to Central Nervous System Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.7 ARG1 CXCL10 ELANE FASLG IL1B MMP9
2 cell surface GO:0009986 9.65 ELANE FAS FASLG SCUBE2 SHH
3 membrane raft GO:0045121 9.46 FAS FASLG SELE SHH
4 extracellular region GO:0005576 9.4 ARG1 CD163 CXCL10 ELANE FAS FASLG

Biological processes related to Central Nervous System Tuberculosis according to GeneCards Suite gene sharing:

(show all 25)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.99 GLI1 IL1B POU3F3 SHH STAT1
2 negative regulation of apoptotic process GO:0043066 9.96 FAS MMP9 POU3F3 SHH TIMP1
3 regulation of signaling receptor activity GO:0010469 9.91 CXCL10 FASLG IL1B SHH TIMP1
4 cell-cell signaling GO:0007267 9.84 CXCL10 FASLG IL1B SHH
5 negative regulation of angiogenesis GO:0016525 9.78 CXCL10 FASLG STAT1
6 leukocyte migration GO:0050900 9.78 ELANE IL1B MMP9 SELE
7 lung development GO:0030324 9.74 ARG1 GLI1 SHH
8 apoptotic signaling pathway GO:0097190 9.7 FAS FASLG SHH
9 extracellular matrix disassembly GO:0022617 9.67 ELANE MMP9 TIMP1
10 cytokine-mediated signaling pathway GO:0019221 9.63 CXCL10 FASLG IL1B MMP9 STAT1 TIMP1
11 positive regulation of epidermal growth factor receptor signaling pathway GO:0045742 9.62 FASLG MMP9
12 response to vitamin D GO:0033280 9.62 CXCL10 IL1B
13 regulation of extrinsic apoptotic signaling pathway via death domain receptors GO:1902041 9.6 FAS FASLG
14 digestive tract morphogenesis GO:0048546 9.58 GLI1 SHH
15 prostate gland development GO:0030850 9.58 GLI1 SHH
16 response to peptide hormone GO:0043434 9.56 ARG1 IL1B STAT1 TIMP1
17 positive regulation of cell proliferation GO:0008284 9.56 CXCL10 FASLG GLI1 IL1B POU3F3 SHH
18 leukocyte migration involved in inflammatory response GO:0002523 9.55 ELANE SELE
19 necroptotic signaling pathway GO:0097527 9.46 FAS FASLG
20 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 9.43 GLI1 SHH
21 metanephric mesenchymal cell proliferation involved in metanephros development GO:0072136 9.4 SHH STAT1
22 positive regulation of immature T cell proliferation in thymus GO:0033092 9.37 IL1B SHH
23 ventral midline development GO:0007418 9.32 GLI1 SHH
24 response to lipopolysaccharide GO:0032496 9.17 ARG1 CXCL10 ELANE FASLG GJB6 IL1B
25 positive regulation of transcription by RNA polymerase II GO:0045944 10.09 CXCL10 GLI1 IL1B POU3F3 SHH STAT1

Molecular functions related to Central Nervous System Tuberculosis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 endopeptidase activity GO:0004175 9.13 ELANE MMP9 SHH
2 cytokine activity GO:0005125 8.92 CXCL10 FASLG IL1B TIMP1

Sources for Central Nervous System Tuberculosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
Content
Loading form....