MCID: CNT046
MIFTS: 45

Central Nervous System Vasculitis

Categories: Neuronal diseases, Cardiovascular diseases

Aliases & Classifications for Central Nervous System Vasculitis

MalaCards integrated aliases for Central Nervous System Vasculitis:

Name: Central Nervous System Vasculitis 12 15
Vasculitis, Central Nervous System 73

Classifications:



External Ids:

Disease Ontology 12 DOID:525
MeSH 44 D020293
NCIt 50 C84622
UMLS 73 C0751878

Summaries for Central Nervous System Vasculitis

MalaCards based summary : Central Nervous System Vasculitis, also known as vasculitis, central nervous system, is related to vasculitis and microscopic polyangiitis. An important gene associated with Central Nervous System Vasculitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Glucosamine and Antibodies have been mentioned in the context of this disorder. Affiliated tissues include brain, endothelial and spinal cord, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Central Nervous System Vasculitis

Diseases related to Central Nervous System Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 343)
# Related Disease Score Top Affiliating Genes
1 vasculitis 31.3 CD40LG CRP TNF
2 microscopic polyangiitis 30.3 HLA-DRB1 TNF
3 relapsing polychondritis 30.0 CRP IL6
4 purpura 29.9 CD40LG CRP TNF
5 familial mediterranean fever 29.5 CRP IL1B TNF
6 brucellosis 29.0 CD40LG CRP IL6 TNF
7 crohn's disease 28.6 CRP IL1B IL6 TLR9 TNF
8 leptospirosis 28.1 CD40LG CRP IL1B IL6 TNF
9 toxoplasmosis 28.0 CD40LG IL1B IL6 TLR9 TNF
10 meningitis 27.9 CD40LG CRP IL1B IL6 TLR9 TNF
11 central nervous system disease 27.5 CD40LG IL1B IL6 SMUG1 TLR9 TNF
12 nervous system disease 27.5 CD40LG IL1B IL6 SMUG1 TLR9 TNF
13 arthritis 27.3 HLA-DRB1 IL17A IL1B IL6 TNF
14 systemic lupus erythematosus 26.7 CD40LG CRP HLA-DRB1 IL17A IL6 TLR9
15 multiple sclerosis 26.7 HLA-DRB1 IL17A IL1B IL6 TLR9 TNF
16 rheumatoid arthritis 26.0 CD40LG CRP HLA-DRB1 IL17A IL1B IL6
17 primary angiitis of the central nervous system 11.4
18 ovarian squamous cell carcinoma 10.9 CRP SMUG1
19 aortitis 10.8 CRP SMUG1
20 cerebral lymphoma 10.8 SMUG1 TLR9
21 cold agglutinin disease 10.8 CRP IL6
22 laryngeal tuberculosis 10.7 CDK9 SMUG1
23 cryopyrin-associated periodic syndrome 10.7 CRP IL6
24 cardiogenic shock 10.7 CRP IL6
25 acute cholangitis 10.7 CRP IL6
26 cardiovascular syphilis 10.7 CD40LG SMUG1
27 neutrophilia, hereditary 10.7 CRP IL6
28 acalculous cholecystitis 10.7 CD40LG CRP
29 chondromalacia 10.7 SMUG1 TNFRSF10A
30 mononeuritis multiplex 10.7 CD40LG CRP
31 eye lymphoma 10.7 IL6 TLR9
32 spinal disease 10.7 CRP IL6
33 castleman disease 10.6 CRP IL6
34 acute maxillary sinusitis 10.6 CD40LG CRP
35 japanese spotted fever 10.6 CD40LG CRP
36 tolosa-hunt syndrome 10.6 CD40LG SMUG1
37 neuronitis 10.6 CD40LG TNFRSF10A
38 geniculate herpes zoster 10.5 CD40LG TNFRSF10A
39 cartilage disease 10.5 CRP SMUG1 TNFRSF10A
40 pericoronitis 10.5 CRP IL1B
41 epididymitis 10.5 CD40LG CRP
42 vasomotor rhinitis 10.5 CD40LG TLR9
43 skeletal tuberculosis 10.5 CRP SMUG1 TNFRSF10A
44 angina pectoris 10.5 CRP IL6
45 dressler's syndrome 10.5 CD40LG CRP
46 intermittent explosive disorder 10.5 CRP IL6 SMUG1
47 polyclonal hypergammaglobulinemia 10.5 CD40LG IL6
48 hypersensitivity vasculitis 10.4 CD40LG CRP
49 recurrent corneal erosion 10.4 IL1B IL6
50 bagassosis 10.4 IL1B IL6

Graphical network of the top 20 diseases related to Central Nervous System Vasculitis:



Diseases related to Central Nervous System Vasculitis

Symptoms & Phenotypes for Central Nervous System Vasculitis

MGI Mouse Phenotypes related to Central Nervous System Vasculitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.91 CRP IL17A IL1B IL6 SMUG1 TLR9
2 immune system MP:0005387 9.76 CD40LG CRP IL17A IL1B IL6 TLR9
3 mortality/aging MP:0010768 9.61 CD40LG CDK9 IL17A IL1B IL6 SMUG1
4 neoplasm MP:0002006 9.02 TNFRSF10A IL1B IL6 SMUG1 TNF

Drugs & Therapeutics for Central Nervous System Vasculitis

Drugs for Central Nervous System Vasculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glucosamine Approved, Investigational, Nutraceutical Not Applicable 3416-24-8 439213
2 Antibodies
3 Immunoglobulins
4 Antibodies, Antiphospholipid
5 Fibrinolytic Agents Not Applicable
6 Glucuronyl glucosamine glycan sulfate Not Applicable
7 Hypoglycemic Agents Not Applicable
8 Hypolipidemic Agents Not Applicable
9 Anticoagulants Not Applicable
10 Lipid Regulating Agents Not Applicable
11 Antimetabolites Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Educational Needs of Patients With Systemic Vasculitis Completed NCT02190929
2 Centralized Reading Assessment of Chronic CerebroSpinal Venous Insufficiency (CCSVI) in Patients With Multiple Sclerosis and Other Neurological Diseases Completed NCT02308579
3 Journey of Patients With Vasculitis From First Symptom to Diagnosis Completed NCT03410290
4 Impact of Vasculitis on Employment and Income Completed NCT02476292
5 Vasculitis Illness Perception (VIP) Study Completed NCT02190916
6 Vessel Wall Imaging for Diagnosis and Monitoring of Central Nervous System (CNS) Vasculitis Recruiting NCT03166319 Not Applicable
7 Pediatric Vasculitis Initiative Recruiting NCT02006134
8 Vasculitis Pregnancy Registry Recruiting NCT02593565
9 Magnetic Resonance Imaging of Intracranial Vasculopathies Not yet recruiting NCT03032809

Search NIH Clinical Center for Central Nervous System Vasculitis

Genetic Tests for Central Nervous System Vasculitis

Anatomical Context for Central Nervous System Vasculitis

MalaCards organs/tissues related to Central Nervous System Vasculitis:

41
Brain, Endothelial, Spinal Cord, Testes

Publications for Central Nervous System Vasculitis

Articles related to Central Nervous System Vasculitis:

(show top 50) (show all 166)
# Title Authors Year
1
Primary central nervous system vasculitis associated with lymphoma. ( 29429967 )
2018
2
Primary central nervous system vasculitis mimicking a brain tumor on conventional magnetic resonance imaging: the usefulness of perfusion-weighted imaging. A case report. ( 29516404 )
2018
3
Isolated Cervical Cord Involvement in Primary Central Nervous System Vasculitis. ( 29961677 )
2018
4
The first case of bacillus Calmette-GuAcrin-induced small-vessel central nervous system vasculitis. ( 29740727 )
2018
5
Primary Central Nervous System Vasculitis ( 29494083 )
2018
6
Central nervous system vasculitis presenting as an ischaemic stroke in a young woman with systemic sclerosis. ( 28977489 )
2017
7
Focal Hemispheric Central Nervous System Vasculitis: An Unusual Form Of Primary Angiitis. ( 28718271 )
2017
8
Central nervous system vasculitis in adults: An update. ( 28087351 )
2017
9
Coccidioidal meningitis complicated by central nervous system vasculitis in a patient with leukemia. ( 28386527 )
2017
10
Case report of a 28-year-old male with the rapid progression of steroid-resistant central nervous system vasculitis diagnosed by a brain biopsy. ( 28804113 )
2017
11
Association of primary central nervous system vasculitis with the presence of specific human leucocyte antigen gene variant. ( 28734234 )
2017
12
Primary central nervous system vasculitis and its mimicking diseases - clinical features, outcome, comorbidities and diagnostic results - A case control study. ( 28324788 )
2017
13
Central nervous system vasculitis in systemic lupus erythematosus: a case series report in a tertiary referral centre. ( 28420057 )
2017
14
Usual and Unusual Manifestations of Systemic and Central Nervous System Vasculitis. ( 27894445 )
2017
15
Primary Central Nervous System Vasculitis Mimicking a Cortical Brain Tumor: A Case Report. ( 28516076 )
2017
16
Central nervous system vasculitis imaging: Simplified. ( 29133684 )
2017
17
Unihemispheric central nervous system vasculitis. ( 29260024 )
2017
18
Concordance of Time-of-Flight MRA and Digital Subtraction Angiography in Adult Primary Central Nervous System Vasculitis. ( 28751515 )
2017
19
Pitfalls of PACNS: A Rare Case of Central Nervous System Vasculitis Associated with Toxoplasmosis. ( 28765346 )
2017
20
Successful Treatment of Central Nervous System Vasculitis Associated with Relapsing Polychondritis With Cyclophosphamide. ( 28502337 )
2017
21
Magnetic resonance imaging in central nervous system vasculitis in a patient affected by crioglobulin-negative hepatitis C virus infection: A likely correlation. ( 28735554 )
2017
22
Central nervous system vasculitis in a patient with HIV infection: a diagnostic challenge. ( 29236897 )
2017
23
Adult Primary Central Nervous System Vasculitis. ( 28786262 )
2017
24
Central nervous system vasculitis in adults and children. ( 27112683 )
2016
25
Management of primary and secondary central nervous system vasculitis. ( 26599380 )
2016
26
Central nervous system vasculitis in pediatric microscopic polyangiitis: A case report and review of literature. ( 27156236 )
2016
27
High-Resolution Vessel Wall MRI : Appearance of Intravascular Lymphoma Mimics Central Nervous System Vasculitis. ( 27530660 )
2016
28
Primary Central Nervous System Vasculitis With Optic Nerve Involvement. ( 26693942 )
2016
29
The Role of Catheter Angiography in the Diagnosis of Central Nervous System Vasculitis. ( 27781050 )
2016
30
354a88Diagnostic Utility of Cerebral Biopsy Following Suggestive Cerebral Angiogram in the Workup of Central Nervous System Vasculitis. ( 27399552 )
2016
31
Isolated Central Nervous System Vasculitis as a Manifestation of Neurosarcoidosis. ( 27083067 )
2016
32
A case of primary central nervous system vasculitis diagnosed by second brain biopsy and treated successfully. ( 26960271 )
2016
33
Primary central nervous system vasculitis preceded by granulomatous hypophysitis: Case report with a review of the literature. ( 26539311 )
2015
34
An update of the Mayo Clinic cohort of patients with adult primary central nervous system vasculitis: description of 163 patients. ( 26020379 )
2015
35
Adult primary central nervous system vasculitis treatment and course: Analysis of 163 patients. ( 25708615 )
2015
36
Primary and secondary central nervous system vasculitis: clinical manifestations, laboratory findings, neuroimaging, and treatment analysis. ( 25425493 )
2015
37
Mycophenolate mofetil in primary central nervous system vasculitis. ( 25800827 )
2015
38
Crohns disease with central nervous system vasculitis causing subarachnoid hemorrhage due to aneurysm and cerebral ischemic stroke. ( 25506170 )
2014
39
High-resolution MRI vessel wall imaging: spatial and temporal patterns of reversible cerebral vasoconstriction syndrome and central nervous system vasculitis. ( 24722305 )
2014
40
Late onset Leigh syndrome mimicking central nervous system vasculitis. ( 27896101 )
2014
41
Unilateral chronic relapsing primary central nervous system vasculitis. ( 24528778 )
2014
42
Varicella zoster-associated retinal and central nervous system vasculitis in a patient with multiple sclerosis treated with natalizumab. ( 24479415 )
2014
43
Central Nervous System vasculitis associated with Hepatitis C virus infection: A brain MRI-supported diagnosis. ( 24211061 )
2014
44
Diagnosis and classification of central nervous system vasculitis. ( 24491822 )
2014
45
Catastrophic primary central nervous system vasculitis. ( 24854370 )
2014
46
Pseudotumoral presentation of primary central nervous system vasculitis. ( 23689414 )
2013
47
Febrile ulceronecrotic Mucha-Habermann disease with central nervous system vasculitis. ( 22276640 )
2013
48
Central nervous system vasculitis secondary to systemic sclerosis. ( 23664129 )
2013
49
L36. Evidence-based clinical science and art in the diagnosis of central nervous system vasculitis. ( 23474051 )
2013
50
Central Nervous System Vasculitis. ( 24435038 )
2013

Variations for Central Nervous System Vasculitis

Expression for Central Nervous System Vasculitis

Search GEO for disease gene expression data for Central Nervous System Vasculitis.

Pathways for Central Nervous System Vasculitis

Pathways related to Central Nervous System Vasculitis according to GeneCards Suite gene sharing:

(show all 49)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.3 CD40LG IL17A IL1B IL6 TLR9 TNF
2
Show member pathways
13.26 CD40LG HLA-DRB1 IL17A IL1B IL6 TNF
3
Show member pathways
13.2 CD40LG IL17A IL1B IL6 TNF TNFRSF10A
4
Show member pathways
12.78 CD40LG HLA-DRB1 IL17A IL1B IL6 TNF
5
Show member pathways
12.64 HLA-DRB1 IL1B IL6 TLR9 TNF TNFRSF10A
6
Show member pathways
12.61 CD40LG IL1B IL6 TLR9 TNF
7
Show member pathways
12.56 IL17A IL1B IL6 TNF
8
Show member pathways
12.52 IL17A IL1B IL6 TNF
9 12.48 CD40LG IL17A IL1B TLR9 TNF
10
Show member pathways
12.44 CD40LG IL1B TLR9 TNF
11
Show member pathways
12.34 HLA-DRB1 IL17A IL1B IL6 TNF
12
Show member pathways
12.3 CD40LG IL17A IL1B IL6 TNF
13
Show member pathways
12.28 CRP IL1B IL6 TNF
14
Show member pathways
12.28 IL17A IL1B IL6 TNF
15
Show member pathways
12.2 CD40LG HLA-DRB1 IL1B TNF
16
Show member pathways
12.18 IL1B IL6 TNF
17
Show member pathways
12.16 IL1B IL6 TLR9 TNF
18
Show member pathways
12.11 IL1B IL6 TLR9 TNF
19 12.1 IL6 TLR9 TNF
20 12.09 IL1B IL6 TNF
21
Show member pathways
12.08 IL17A IL1B IL6 TLR9 TNF
22 12.02 HLA-DRB1 IL1B IL6 TLR9 TNF
23
Show member pathways
12 IL17A IL1B IL6 TNFRSF10A
24 11.94 IL1B IL6 TNF
25 11.91 IL17A IL1B IL6 TNF
26 11.89 IL1B IL6 TNF
27 11.85 IL1B IL6 TNF
28 11.83 IL1B IL6 TNF
29 11.82 CD40LG IL1B TNF
30 11.82 HLA-DRB1 IL1B IL6 TNF
31 11.74 IL17A IL1B TNF
32 11.71 IL1B IL6 TNF
33 11.63 IL1B IL6 TNF
34 11.63 IL1B IL6 TLR9 TNF
35 11.55 IL1B IL6 TNF
36
Show member pathways
11.53 CD40LG IL1B IL6 TNF
37 11.5 IL1B IL6 TNF
38 11.45 IL1B IL6 TNF
39 11.31 HLA-DRB1 IL17A IL1B IL6 TNF
40 11.3 IL1B IL6 TNF
41 11.24 IL1B IL6 TNF
42 11.17 IL1B IL6 TLR9 TNF
43 11.06 IL17A IL1B IL6 TNF
44 11.04 IL1B TNF
45 11.04 IL6 TNF
46 10.97 CRP IL6 TNF
47 10.93 HLA-DRB1 IL1B IL6 TNF
48 10.9 IL1B TNF
49 10.71 CD40LG IL1B IL6 TLR9 TNF

GO Terms for Central Nervous System Vasculitis

Cellular components related to Central Nervous System Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.7 CD40LG CRP IL17A IL1B IL6 TLR9
2 external side of plasma membrane GO:0009897 9.26 CD40LG HLA-DRB1 IL17A TNF
3 extracellular space GO:0005615 9.17 CD40LG CRP IL17A IL1B IL6 TLR9

Biological processes related to Central Nervous System Vasculitis according to GeneCards Suite gene sharing:

(show all 35)
# Name GO ID Score Top Affiliating Genes
1 cytokine-mediated signaling pathway GO:0019221 9.9 IL17A IL1B IL6 TNF
2 regulation of signaling receptor activity GO:0010469 9.88 CD40LG IL17A IL1B IL6 TNF
3 positive regulation of I-kappaB kinase/NF-kappaB signaling GO:0043123 9.84 IL1B TLR9 TNF
4 positive regulation of MAPK cascade GO:0043410 9.83 IL6 TLR9 TNFRSF10A
5 positive regulation of gene expression GO:0010628 9.83 CRP IL1B IL6 TLR9 TNF
6 tumor necrosis factor-mediated signaling pathway GO:0033209 9.81 CD40LG TNF TNFRSF10A
7 positive regulation of DNA binding transcription factor activity GO:0051091 9.8 IL1B IL6 TNF
8 defense response to Gram-positive bacterium GO:0050830 9.79 CRP IL6 TNF
9 positive regulation of JNK cascade GO:0046330 9.74 IL1B TLR9 TNF
10 positive regulation of T cell proliferation GO:0042102 9.72 CD40LG IL1B IL6
11 positive regulation of interleukin-12 production GO:0032735 9.67 CD40LG TLR9
12 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.67 IL1B TLR9 TNF
13 positive regulation of interleukin-6 secretion GO:2000778 9.66 IL17A IL1B
14 positive regulation of interleukin-10 production GO:0032733 9.65 CD40LG TLR9
15 positive regulation of osteoclast differentiation GO:0045672 9.65 IL17A TNF
16 negative regulation of lipid catabolic process GO:0050995 9.64 IL1B TNF
17 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.63 IL1B TNF
18 inflammatory response to antigenic stimulus GO:0002437 9.63 HLA-DRB1 IL1B
19 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.62 IL1B TNF
20 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.61 IL1B TLR9
21 positive regulation of histone phosphorylation GO:0033129 9.59 CDK9 IL1B
22 positive regulation of chemokine biosynthetic process GO:0045080 9.58 IL1B TNF
23 regulation of establishment of endothelial barrier GO:1903140 9.58 IL1B TNF
24 positive regulation of interleukin-8 production GO:0032757 9.58 IL1B TLR9 TNF
25 positive regulation of interleukin-6 production GO:0032755 9.56 IL1B IL6 TLR9 TNF
26 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.55 CD40LG IL1B IL6 TLR9 TNF
27 positive regulation of fever generation GO:0031622 9.54 IL1B TNF
28 positive regulation of chemokine production GO:0032722 9.54 IL6 TLR9 TNF
29 regulation of immunoglobulin secretion GO:0051023 9.52 CD40LG TNF
30 sequestering of triglyceride GO:0030730 9.51 IL1B TNF
31 negative regulation of lipid storage GO:0010888 9.5 CRP IL6 TNF
32 immune response GO:0006955 9.5 CD40LG HLA-DRB1 IL17A IL1B IL6 TNF
33 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 9.46 IL1B TNF
34 inflammatory response GO:0006954 9.23 CD40LG CRP IL17A IL1B IL6 TLR9
35 positive regulation of transcription by RNA polymerase II GO:0045944 10.03 CDK9 IL17A IL1B IL6 TLR9 TNF

Molecular functions related to Central Nervous System Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 CD40LG IL17A IL1B IL6 TNF
2 interleukin-1 receptor binding GO:0005149 8.96 IL1B TLR9

Sources for Central Nervous System Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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