MCID: CNT046
MIFTS: 43

Central Nervous System Vasculitis

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Central Nervous System Vasculitis

MalaCards integrated aliases for Central Nervous System Vasculitis:

Name: Central Nervous System Vasculitis 12 15
Vasculitis, Central Nervous System 73

Classifications:



External Ids:

Disease Ontology 12 DOID:525
MeSH 44 D020293
NCIt 50 C84622
UMLS 73 C0751878

Summaries for Central Nervous System Vasculitis

Disease Ontology : 12 A vasculitis that is characterized by inflammation of blood vessel walls in the brain or spine.

MalaCards based summary : Central Nervous System Vasculitis, also known as vasculitis, central nervous system, is related to crohn's disease and purpura. An important gene associated with Central Nervous System Vasculitis is CRP (C-Reactive Protein), and among its related pathways/superpathways are Akt Signaling and Cytokine Signaling in Immune system. The drugs Glucosamine and Antibodies, Antiphospholipid have been mentioned in the context of this disorder. Affiliated tissues include brain, lung and liver, and related phenotypes are homeostasis/metabolism and immune system

Related Diseases for Central Nervous System Vasculitis

Diseases related to Central Nervous System Vasculitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 362)
# Related Disease Score Top Affiliating Genes
1 crohn's disease 30.2 TNF TLR9 CRP
2 purpura 30.2 TNF IL6 CRP
3 microscopic polyangiitis 30.2 TNF HLA-DRB1
4 relapsing polychondritis 29.8 CRP IFNG IL6
5 familial mediterranean fever 29.8 TNF IL1B CRP
6 uveitis 29.7 TNF IL17A IFNG
7 cytomegalovirus infection 29.7 IL1B IL6 TNF
8 human immunodeficiency virus infectious disease 29.6 IFNG IL6 TLR9 TNF
9 viral infectious disease 29.5 IFNG IL1B IL6 TLR9 TNF
10 meningitis 29.5 CRP IFNG IL1B IL6 TLR9 TNF
11 leptospirosis 29.2 CRP IFNG IL1B IL6 TNF
12 toxoplasmosis 29.1 IFNG IL1B IL6 TLR9 TNF
13 nervous system disease 28.8 CRP IFNG IL1B IL6 SMUG1 TLR9
14 arthritis 28.8 HLA-DRB1 IFNG IL17A IL1B IL6 TNF
15 systemic lupus erythematosus 28.8 CRP HLA-DRB1 IFNG IL17A IL1B IL6
16 central nervous system disease 28.8 IFNG IL17A IL1B IL6 TLR9 TNF
17 rheumatoid arthritis 28.7 CRP HLA-DRB1 IFNG IL17A IL1B IL6
18 multiple sclerosis 28.6 HLA-DRB1 IFNG IL17A IL1B IL6 TLR9
19 primary angiitis of the central nervous system 11.9
20 vasculitis 11.0
21 gastrointestinal tuberculosis 10.3 SMUG1 CRP
22 aortitis 10.3 SMUG1 CRP
23 laryngeal tuberculosis 10.3 CDK9 SMUG1
24 chondromalacia 10.3 TNFRSF10A SMUG1
25 hirata disease 10.3 TNFRSF10A HLA-DRB1
26 neutrophilia, hereditary 10.3 CRP IL6
27 spinal disease 10.3 CRP IL6
28 multicentric castleman disease 10.3 CRP IL6
29 acute cholangitis 10.3 IL6 CRP
30 cerebral lymphoma 10.3 TLR9 SMUG1
31 subacute thyroiditis 10.3 CRP IL6
32 cold agglutinin disease 10.3 IL6 CRP
33 cryopyrin-associated periodic syndrome 10.3 IL6 CRP
34 rheumatoid arthritis, systemic juvenile 10.3 HLA-DRB1 IL6
35 melancholia 10.2 TNF CRP
36 salpingitis 10.2 TNF CRP
37 drug reaction with eosinophilia and systemic symptoms 10.2 TNF CRP
38 microscopic colitis 10.2 HLA-DRB1 TNF
39 sympathetic ophthalmia 10.2 HLA-DRB1 TNF
40 eye lymphoma 10.2 TLR9 IL6
41 nontuberculous mycobacterial lung disease 10.2 HLA-DRB1 TNF
42 rheumatoid vasculitis 10.2 HLA-DRB1 TNF
43 posterior scleritis 10.2 TNFRSF10A TNF
44 adult dermatomyositis 10.2 TNF TLR9
45 pericardial tuberculosis 10.2 IFNG SMUG1
46 berylliosis 10.2 IFNG HLA-DRB1
47 mucocutaneous leishmaniasis 10.2 TNF TLR9
48 retinitis pigmentosa 55 10.2 TNF IL6
49 critical limb ischemia 10.2 TNF IL6
50 angioimmunoblastic lymphadenopathy with dysproteinemia 10.2 TNF IL6

Graphical network of the top 20 diseases related to Central Nervous System Vasculitis:



Diseases related to Central Nervous System Vasculitis

Symptoms & Phenotypes for Central Nervous System Vasculitis

MGI Mouse Phenotypes related to Central Nervous System Vasculitis:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 homeostasis/metabolism MP:0005376 9.91 CRP IFNG IL17A IL1B IL6 SMUG1
2 immune system MP:0005387 9.76 CRP IFNG IL17A IL1B IL6 TLR9
3 mortality/aging MP:0010768 9.61 CDK9 IFNG IL17A IL1B IL6 SMUG1
4 neoplasm MP:0002006 9.1 IFNG IL1B IL6 SMUG1 TNF TNFRSF10A

Drugs & Therapeutics for Central Nervous System Vasculitis

Drugs for Central Nervous System Vasculitis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 11)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Glucosamine Approved, Investigational Not Applicable 3416-24-8 439213
2 Antibodies, Antiphospholipid
3 Immunoglobulins
4 Antibodies
5 Fibrinolytic Agents Not Applicable
6 Hypoglycemic Agents Not Applicable
7 Glucuronyl glucosamine glycan sulfate Not Applicable
8 Lipid Regulating Agents Not Applicable
9 Hypolipidemic Agents Not Applicable
10 Antimetabolites Not Applicable
11 Anticoagulants Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Educational Needs of Patients With Systemic Vasculitis Completed NCT02190929
2 Centralized Reading Assessment of Chronic CerebroSpinal Venous Insufficiency (CCSVI) in Patients With Multiple Sclerosis and Other Neurological Diseases Completed NCT02308579
3 Journey of Patients With Vasculitis From First Symptom to Diagnosis Completed NCT03410290
4 Impact of Vasculitis on Employment and Income Completed NCT02476292
5 Vasculitis Illness Perception (VIP) Study Completed NCT02190916
6 Vessel Wall Imaging for Diagnosis and Monitoring of Central Nervous System (CNS) Vasculitis Recruiting NCT03166319 Not Applicable
7 Magnetic Resonance Imaging of Intracranial Vasculopathies Recruiting NCT03032809
8 Pediatric Vasculitis Initiative Recruiting NCT02006134
9 Vasculitis Pregnancy Registry Recruiting NCT02593565

Search NIH Clinical Center for Central Nervous System Vasculitis

Genetic Tests for Central Nervous System Vasculitis

Anatomical Context for Central Nervous System Vasculitis

MalaCards organs/tissues related to Central Nervous System Vasculitis:

41
Brain, Lung, Liver, Bone, Heart, Eye, B Cells

Publications for Central Nervous System Vasculitis

Articles related to Central Nervous System Vasculitis:

(show top 50) (show all 175)
# Title Authors Year
1
Primary central nervous system vasculitis associated with lymphoma. ( 29429967 )
2018
2
Primary central nervous system vasculitis mimicking a brain tumor on conventional magnetic resonance imaging: the usefulness of perfusion-weighted imaging. A case report. ( 29516404 )
2018
3
Isolated Cervical Cord Involvement in Primary Central Nervous System Vasculitis. ( 29961677 )
2018
4
The first case of bacillus Calmette-GuAcrin-induced small-vessel central nervous system vasculitis. ( 29740727 )
2018
5
Primary Central Nervous System Vasculitis ( 29494083 )
2018
6
Vessel wall enhancement on MRI in the diagnosis of primary central nervous system vasculitis. ( 30102571 )
2018
7
Central Nervous System Vasculitis for Cryptococcosis in an Immunocompetent Patient. ( 30200288 )
2018
8
Pyogenic Meningitis Complicated with Extensive Central Nervous System Vasculitis and Moyamoya Vasculopathy. ( 30271471 )
2018
9
A Long Interval from a Spinal Cord Lesion to a Subsequent Brain Lesion in Primary Central Nervous System Vasculitis: A Case Report. ( 30449796 )
2018
10
Recurrent strokes, central nervous system vasculitis, and acquired protein S deficiency secondary to varicella zoster in a child with AIDS. ( 30478796 )
2018
11
Primary central nervous system vasculitis mimicking brain tumor: Comprehensive analysis of 13 cases from a single institutional cohort of 191 cases. ( 30528173 )
2018
12
Treatment and Long-Term Outcomes of Primary Central Nervous System Vasculitis. ( 29986936 )
2018
13
FET PET in Primary Central Nervous System Vasculitis. ( 30080188 )
2018
14
Central nervous system vasculitis presenting as an ischaemic stroke in a young woman with systemic sclerosis. ( 28977489 )
2017
15
Focal Hemispheric Central Nervous System Vasculitis: An Unusual Form Of Primary Angiitis. ( 28718271 )
2017
16
Central nervous system vasculitis in adults: An update. ( 28087351 )
2017
17
Coccidioidal meningitis complicated by central nervous system vasculitis in a patient with leukemia. ( 28386527 )
2017
18
Case report of a 28-year-old male with the rapid progression of steroid-resistant central nervous system vasculitis diagnosed by a brain biopsy. ( 28804113 )
2017
19
Association of primary central nervous system vasculitis with the presence of specific human leucocyte antigen gene variant. ( 28734234 )
2017
20
Primary central nervous system vasculitis and its mimicking diseases - clinical features, outcome, comorbidities and diagnostic results - A case control study. ( 28324788 )
2017
21
Central nervous system vasculitis in systemic lupus erythematosus: a case series report in a tertiary referral centre. ( 28420057 )
2017
22
Usual and Unusual Manifestations of Systemic and Central Nervous System Vasculitis. ( 27894445 )
2017
23
Primary Central Nervous System Vasculitis Mimicking a Cortical Brain Tumor: A Case Report. ( 28516076 )
2017
24
Central nervous system vasculitis imaging: Simplified. ( 29133684 )
2017
25
Unihemispheric central nervous system vasculitis. ( 29260024 )
2017
26
Concordance of Time-of-Flight MRA and Digital Subtraction Angiography in Adult Primary Central Nervous System Vasculitis. ( 28751515 )
2017
27
Pitfalls of PACNS: A Rare Case of Central Nervous System Vasculitis Associated with Toxoplasmosis. ( 28765346 )
2017
28
Successful Treatment of Central Nervous System Vasculitis Associated with Relapsing Polychondritis With Cyclophosphamide. ( 28502337 )
2017
29
Magnetic resonance imaging in central nervous system vasculitis in a patient affected by crioglobulin-negative hepatitis C virus infection: A likely correlation. ( 28735554 )
2017
30
Central nervous system vasculitis in a patient with HIV infection: a diagnostic challenge. ( 29236897 )
2017
31
Adult Primary Central Nervous System Vasculitis. ( 28786262 )
2017
32
Central nervous system vasculitis in adults and children. ( 27112683 )
2016
33
Management of primary and secondary central nervous system vasculitis. ( 26599380 )
2016
34
Central nervous system vasculitis in pediatric microscopic polyangiitis: A case report and review of literature. ( 27156236 )
2016
35
High-Resolution Vessel Wall MRI : Appearance of Intravascular Lymphoma Mimics Central Nervous System Vasculitis. ( 27530660 )
2016
36
Response to "High-Resolution Vessel Wall MRI: Appearance of Intravascular Lymphoma Mimics Central Nervous System Vasculitis". ( 27822627 )
2016
37
Primary Central Nervous System Vasculitis With Optic Nerve Involvement. ( 26693942 )
2016
38
The Role of Catheter Angiography in the Diagnosis of Central Nervous System Vasculitis. ( 27781050 )
2016
39
354a88Diagnostic Utility of Cerebral Biopsy Following Suggestive Cerebral Angiogram in the Workup of Central Nervous System Vasculitis. ( 27399552 )
2016
40
Isolated Central Nervous System Vasculitis as a Manifestation of Neurosarcoidosis. ( 27083067 )
2016
41
A case of primary central nervous system vasculitis diagnosed by second brain biopsy and treated successfully. ( 26960271 )
2016
42
Primary central nervous system vasculitis preceded by granulomatous hypophysitis: Case report with a review of the literature. ( 26539311 )
2015
43
An update of the Mayo Clinic cohort of patients with adult primary central nervous system vasculitis: description of 163 patients. ( 26020379 )
2015
44
Adult primary central nervous system vasculitis treatment and course: Analysis of 163 patients. ( 25708615 )
2015
45
Primary and secondary central nervous system vasculitis: clinical manifestations, laboratory findings, neuroimaging, and treatment analysis. ( 25425493 )
2015
46
Mycophenolate mofetil in primary central nervous system vasculitis. ( 25800827 )
2015
47
Crohns disease with central nervous system vasculitis causing subarachnoid hemorrhage due to aneurysm and cerebral ischemic stroke. ( 25506170 )
2014
48
High-resolution MRI vessel wall imaging: spatial and temporal patterns of reversible cerebral vasoconstriction syndrome and central nervous system vasculitis. ( 24722305 )
2014
49
Late onset Leigh syndrome mimicking central nervous system vasculitis. ( 27896101 )
2014
50
Unilateral chronic relapsing primary central nervous system vasculitis. ( 24528778 )
2014

Variations for Central Nervous System Vasculitis

Expression for Central Nervous System Vasculitis

Search GEO for disease gene expression data for Central Nervous System Vasculitis.

Pathways for Central Nervous System Vasculitis

Pathways related to Central Nervous System Vasculitis according to GeneCards Suite gene sharing:

(show top 50) (show all 63)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.33 IL17A IL1B IL6 TLR9 TNF TNFRSF10A
2
Show member pathways
13.29 HLA-DRB1 IFNG IL17A IL1B IL6 TNF
3
Show member pathways
12.95 IFNG IL1B IL6 TLR9 TNF
4
Show member pathways
12.82 HLA-DRB1 IFNG IL17A IL1B IL6 TNF
5
Show member pathways
12.71 HLA-DRB1 IFNG IL1B IL6 TLR9 TNF
6
Show member pathways
12.69 IFNG IL1B IL6 TNF
7
Show member pathways
12.64 IL1B IL6 TLR9 TNF
8
Show member pathways
12.56 IL1B TLR9 TNF TNFRSF10A
9
Show member pathways
12.56 IFNG IL17A IL1B IL6 TNF
10 12.54 IFNG IL17A IL1B TLR9 TNF
11
Show member pathways
12.53 HLA-DRB1 IFNG IL17A IL1B IL6 TNF
12
Show member pathways
12.38 IFNG IL17A IL1B IL6 TNF
13
Show member pathways
12.29 IFNG IL1B IL6 TNF
14
Show member pathways
12.29 CRP IFNG IL1B IL6 TNF
15
Show member pathways
12.28 IFNG IL17A IL1B IL6 TNF
16
Show member pathways
12.25 IFNG IL17A IL1B IL6 TNF
17
Show member pathways
12.24 HLA-DRB1 IFNG IL1B TNF
18
Show member pathways
12.2 IL1B IL6 TLR9 TNF
19
Show member pathways
12.2 IFNG IL1B TNF TNFRSF10A
20 12.17 IFNG IL6 TLR9 TNF
21
Show member pathways
12.14 IFNG IL1B IL6 TLR9 TNF
22 12.13 HLA-DRB1 IFNG IL1B IL6 TLR9 TNF
23 12.12 IL1B IL6 TNF
24
Show member pathways
12.06 IFNG IL17A IL1B IL6 TNFRSF10A
25 12.04 IFNG IL1B TNF
26
Show member pathways
12.03 IFNG IL1B IL6 TNF
27 12 IFNG IL1B TNF
28 12 IFNG IL1B IL6 TNF
29 11.97 IL17A IL1B IL6 TNF
30 11.95 IFNG IL6 TNF
31
Show member pathways
11.94 HLA-DRB1 IFNG IL1B
32 11.92 IL1B IL6 TNF
33 11.91 IFNG IL1B IL6
34
Show member pathways
11.91 IFNG IL17A IL1B IL6 TLR9 TNF
35 11.89 HLA-DRB1 IL1B IL6 TNF
36 11.87 IL1B IL6 TNF
37 11.87 IFNG IL1B IL6 TNF
38 11.81 IFNG IL1B IL6
39 11.77 IFNG IL17A IL1B TNF
40 11.75 IL1B IL6 TNF
41 11.72 IFNG IL1B IL6 TLR9 TNF
42 11.68 IFNG IL17A IL1B IL6 TNF
43 11.66 IL1B IL6 TNF
44
Show member pathways
11.64 IFNG IL1B IL6 TNF
45 11.6 IL1B IL6 TNF
46 11.57 IFNG IL6 TNF
47 11.55 IL1B IL6 TNF
48 11.53 IFNG IL1B TNF
49 11.53 IFNG IL1B TNF
50 11.46 IFNG IL1B IL6 TLR9 TNF

GO Terms for Central Nervous System Vasculitis

Cellular components related to Central Nervous System Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular region GO:0005576 9.17 CRP IFNG IL17A IL1B IL6 TLR9

Biological processes related to Central Nervous System Vasculitis according to GeneCards Suite gene sharing:

(show all 45)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.98 IFNG IL17A IL1B IL6 TNF
2 cytokine-mediated signaling pathway GO:0019221 9.96 IL17A IL1B IL6 TNF
3 positive regulation of gene expression GO:0010628 9.88 CRP IFNG IL1B IL6 TLR9 TNF
4 cellular response to lipopolysaccharide GO:0071222 9.86 IL1B IL6 TNF
5 positive regulation of DNA-binding transcription factor activity GO:0051091 9.85 IL1B IL6 TNF
6 positive regulation of NF-kappaB transcription factor activity GO:0051092 9.85 IL1B IL6 TLR9 TNF
7 defense response to Gram-positive bacterium GO:0050830 9.84 CRP IL6 TNF
8 positive regulation of JNK cascade GO:0046330 9.83 IL1B TLR9 TNF
9 regulation of insulin secretion GO:0050796 9.81 IFNG IL1B TNF
10 response to glucocorticoid GO:0051384 9.8 IL1B IL6 TNF
11 humoral immune response GO:0006959 9.8 IFNG IL6 TNF
12 positive regulation of NIK/NF-kappaB signaling GO:1901224 9.78 IL1B TLR9 TNF
13 extrinsic apoptotic signaling pathway GO:0097191 9.75 IFNG TNF TNFRSF10A
14 positive regulation of nitric oxide biosynthetic process GO:0045429 9.74 IFNG IL1B TNF
15 positive regulation of JUN kinase activity GO:0043507 9.73 IL1B TLR9 TNF
16 inflammatory response GO:0006954 9.73 CRP IL17A IL1B IL6 TLR9 TNF
17 positive regulation of interleukin-12 production GO:0032735 9.7 IFNG TLR9
18 positive regulation of interleukin-8 production GO:0032757 9.7 IL1B TLR9 TNF
19 positive regulation of interleukin-6 secretion GO:2000778 9.69 IL17A IL1B
20 positive regulation of protein complex assembly GO:0031334 9.69 IFNG TNF
21 negative regulation of neurogenesis GO:0050768 9.69 IL1B IL6 TNF
22 protein import into nucleus, translocation GO:0000060 9.68 IFNG TNF
23 negative regulation of lipid catabolic process GO:0050995 9.68 IL1B TNF
24 regulation of I-kappaB kinase/NF-kappaB signaling GO:0043122 9.68 IL1B TNF
25 positive regulation of heterotypic cell-cell adhesion GO:0034116 9.68 IL1B TNF
26 positive regulation of granulocyte macrophage colony-stimulating factor production GO:0032725 9.67 IL1B TLR9
27 positive regulation of osteoclast differentiation GO:0045672 9.67 IFNG IL17A TNF
28 positive regulation of interleukin-6 production GO:0032755 9.67 IL1B IL6 TLR9 TNF
29 positive regulation of interleukin-8 biosynthetic process GO:0045416 9.66 TLR9 TNF
30 positive regulation of chemokine biosynthetic process GO:0045080 9.65 IL1B TNF
31 positive regulation of histone phosphorylation GO:0033129 9.65 CDK9 IL1B
32 positive regulation of chemokine production GO:0032722 9.65 IL6 TLR9 TNF
33 regulation of establishment of endothelial barrier GO:1903140 9.64 IL1B TNF
34 positive regulation of glial cell proliferation GO:0060252 9.63 IL1B IL6 TNF
35 positive regulation of fever generation GO:0031622 9.62 IL1B TNF
36 positive regulation of interleukin-23 production GO:0032747 9.61 IFNG IL17A
37 positive regulation of membrane protein ectodomain proteolysis GO:0051044 9.61 IFNG IL1B TNF
38 chronic inflammatory response to antigenic stimulus GO:0002439 9.6 IL1B TNF
39 sequestering of triglyceride GO:0030730 9.59 IL1B TNF
40 positive regulation of vitamin D biosynthetic process GO:0060557 9.54 IFNG TNF
41 negative regulation of lipid storage GO:0010888 9.5 CRP IL6 TNF
42 immune response GO:0006955 9.5 HLA-DRB1 IFNG IL17A IL1B IL6 TLR9
43 positive regulation of neuroinflammatory response GO:0150078 9.33 IL1B IL6 TNF
44 positive regulation of calcidiol 1-monooxygenase activity GO:0060559 8.8 IFNG IL1B TNF
45 positive regulation of transcription by RNA polymerase II GO:0045944 10.12 CDK9 IL17A IL1B IL6 TLR9 TNF

Molecular functions related to Central Nervous System Vasculitis according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 9.02 IFNG IL17A IL1B IL6 TNF
2 interleukin-1 receptor binding GO:0005149 8.96 IL1B TLR9

Sources for Central Nervous System Vasculitis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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