Central Neurocytoma disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Central Neurocytoma

MalaCards integrated aliases for Central Neurocytoma:

Name: Central Neurocytoma ¹¹ ¹⁹ ⁵⁸ ¹⁴ ¹⁶ ⁷¹ ⁷⁵

Neurocytoma ⁴³ ⁷¹

Neurocytoma Central ⁵³

Neurolipocytoma ¹¹

Characteristics:

Age Of Onset:

Adolescent,Adult,Childhood ⁵⁸

Classifications:

MalaCards categories:
Global: Rare diseases Cancer diseases
Anatomical: Neuronal diseases Eye diseases Mental diseases

See all MalaCards categories (disease lists)

Orphanet: ⁵⁸

Rare neurological diseases

External Ids:

Disease Ontology ¹¹ DOID:14174

MeSH ⁴³ D018306

NCIt ⁴⁹ C3791

SNOMED-CT ⁶⁸ 302832007

UMLS via Orphanet ⁷² C0206719

Orphanet ⁵⁸ ORPHA73256

EFO ¹⁶ EFO_1000856

UMLS ⁷¹ C0206719 C1622510

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Summaries for Central Neurocytoma

GARD: ¹⁹ Central neurocytoma is a very rare brain tumor of young adults (over 100 cases reported worldwide). It is typically found in the lateral ventricles and occasionally in the third ventricle. Symptoms are those of increased intracranial pressure: headache, nausea and vomiting, drowsiness, vision problems and mental changes. Total removal of the tumor is the therapy of choice. Post-operative prognosis is generally good.

MalaCards based summary: Central Neurocytoma, also known as neurocytoma, is related to cerebellar liponeurocytoma and cellular ependymoma, and has symptoms including vomiting and headache. An important gene associated with Central Neurocytoma is SYP (Synaptophysin), and among its related pathways/superpathways are Neuroscience and Neural crest differentiation. The drugs Trametinib and Dabrafenib have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and medulla oblongata, and related phenotypes are hydrocephalus and intracranial cystic lesion

Orphanet: ⁵⁸ Central neurocytoma is a very rare brain tumor of young adults (over 100 cases reported worldwide). It is typically found in the lateral ventricles and occasionally in the third ventricle. Symptoms are those of increased intracranial pressure: headache, nausea and vomiting, drowsiness, vision problems and mental changes. Total removal of the tumor is the therapy of choice. Post-operative prognosis is generally good.

Wikipedia: ⁷⁵ Central neurocytoma (CNC) is an extremely rare, ordinarily benign intraventricular brain tumour that... more...

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Related Diseases for Central Neurocytoma

Diseases related to Central Neurocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 371)

#	Related Disease	Score	Top Affiliating Genes
1	cerebellar liponeurocytoma	31.7	SYP RBFOX3 MAP2 ENO2
2	cellular ependymoma	31.1	SYP NES GFAP
3	hydrocephalus	30.7	SYP SNCA NES GFAP ENO2
4	mature teratoma	30.4	SYP ENO2
5	oligodendroglioma	30.4	SYP OLIG2 IDH1 GFAP ENO2 CHGA
6	obstructive hydrocephalus	30.4	SYP OLIG2 KIAA1549 GFAP ENO2
7	cauda equina syndrome	30.3	SYP GFAP
8	cerebral neuroblastoma	30.3	SYP GFAP ENO2 CHGA
9	papilloma of choroid plexus	30.1	SYP GFAP ENO2
10	olfactory neuroblastoma	30.1	SYP ENO2 CHGA
11	cystic teratoma	30.1	SYP ENO2 CHGA
12	brain cancer	30.0	SYP OLIG2 NES IDH1 GFAP FGF2
13	benign teratoma	30.0	SYP ENO2 CHGA
14	islet cell tumor	30.0	SYP ENO2 CHGA
15	ewing sarcoma	30.0	SYP NES ENO2 CHGA
16	neuroma	29.9	GFAP FGF2 ENO2
17	hemangioblastoma	29.9	SYP GFAP ENO2
18	clear cell ependymoma	29.9	SYP RBFOX3 OLIG2 GFAP
19	subependymal giant cell astrocytoma	29.8	SYP KIAA1549 GFAP ENO2
20	ganglioneuroma	29.7	SYP GFAP ENO2 CHGA
21	anaplastic astrocytoma	29.6	OLIG2 NES KIAA1549 IDH1 GFAP
22	toxic encephalopathy	29.6	SYP SNCA RBFOX3 MAP2 GFAP
23	neuroblastoma	29.6	SYP SNCA NES MAP2 GFAP FGF2
24	high grade ependymoma	29.5	OLIG2 KIAA1549 IDH1 GFAP
25	paraganglioma	29.5	SYP GFAP FGF2 ENO2 CHGA
26	ganglioglioma	29.5	SYP NES MAP2 GFAP ENO2 CHGA
27	teratoma	29.5	SYP NES MAP2 GFAP ENO2 CHGA
28	neurofibromatosis, type i	29.3	KIAA1549 IDH1 ENO2
29	diffuse astrocytoma	29.3	OLIG2 KIAA1549 IDH1 GFAP
30	stroke, ischemic	29.3	RBFOX3 NES MAP2 GFAP ENO2
31	anaplastic oligodendroglioma	29.3	OLIG2 NES KIAA1549 IDH1 GFAP
32	meningioma, familial	29.3	SYP OLIG2 KIAA1549 IDH1 GFAP ENO2
33	dysembryoplastic neuroepithelial tumor	29.1	SYP RBFOX3 OLIG2 KIAA1549 IDH1 GFAP
34	medulloblastoma	29.0	SYP OLIG2 NES MAP2 IDH1 GFAP
35	spinal cord disease	28.9	SYP OLIG2 NES KIAA1549 IDH1 GFAP
36	pilocytic astrocytoma	28.9	SYP OLIG2 NES KIAA1549 IDH1 GFAP
37	central nervous system benign neoplasm	28.8	SYP OLIG2 NES KIAA1549 IDH1 GFAP
38	gangliocytoma	28.7	SYP RBFOX3 KIAA1549 IDH1 GFAP ENO2
39	extraventricular neurocytoma	11.2
40	papillary glioneuronal tumors	11.0
41	glioma susceptibility 1	10.7
42	neuronal tumor	10.5
43	intracranial hypertension	10.4
44	rare tumor	10.4
45	central nervous system cancer	10.4
46	papillary ependymoma	10.4	SYP GFAP
47	third ventricle chordoid glioma	10.3	OLIG2 GFAP
48	central nervous system immature teratoma	10.3	NES GFAP
49	bladder small cell carcinoma	10.3	SYP ENO2
50	pancreas lymphoma	10.3	SYP CHGA

Graphical network of the top 20 diseases related to Central Neurocytoma:

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Symptoms & Phenotypes for Central Neurocytoma

Human phenotypes related to Central Neurocytoma:

⁵⁸ ³⁰ (show all 20)

#	Description	HPO Frequency	Orphanet Frequency	HPO Source Accession
1	hydrocephalus ⁵⁸ ³⁰	Obligate (100%)	Obligate (100%)	HP:0000238
2	intracranial cystic lesion ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0010576
3	abnormal cellular phenotype ⁵⁸ ³⁰	Hallmark (90%)	Very frequent (99-80%)	HP:0025354
4	abnormal lateral ventricle morphology ³⁰	Hallmark (90%)		HP:0030047
5	nausea and vomiting ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002017
6	depression ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0000716
7	ataxia ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0001251
8	cerebral calcification ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002514
9	increased intracranial pressure ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002516
10	abnormality of vision ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0000504
11	headache ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0002315
12	decreased corneal reflex ⁵⁸ ³⁰	Frequent (33%)	Frequent (79-30%)	HP:0008000
13	paresthesia ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0003401
14	lethargy ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001254
15	babinski sign ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0003487
16	coma ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0001259
17	tinnitus ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0000360
18	pain insensitivity ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0007021
19	postural instability ⁵⁸ ³⁰	Occasional (7.5%)	Occasional (29-5%)	HP:0002172
20	abnormality of lateral ventricle ⁵⁸		Very frequent (99-80%)

UMLS symptoms related to Central Neurocytoma:

vomiting; headache

MGI Mouse Phenotypes related to Central Neurocytoma:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	9.7	CHGA ENO2 FGF2 GFAP IDH1 MAP2
2	behavior/neurological	MP:0005386	9.32	ENO2 FGF2 GFAP KIAA1549 MAP2 NES

Sources

Drugs & Therapeutics for Central Neurocytoma

Drugs for Central Neurocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Trametinib

Approved

Phase 4

871700-17-3

11707110

2

Dabrafenib

Approved, Investigational

Phase 4

1195765-45-7

44462760

3

Protein Kinase Inhibitors

Phase 4

4

Carboplatin

Approved

Phase 2

41575-94-4

10339178 38904

5

Vincristine

Approved, Investigational

Phase 2

2068-78-2, 57-22-7

5978

6

Antimitotic Agents

Phase 2

7

Tubulin Modulators

Phase 2

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	An Open Label, Multi-center Roll-over Study to Assess Long-term Effect in Pediatric Patients Treated With Tafinlar (Dabrafenib) and/or Mekinist (Trametinib)	Recruiting	NCT03975829	Phase 4	dabrafenib;trametinib
2	Phase II Open-label Global Study to Evaluate the Effect of Dabrafenib in Combination With Trametinib in Children and Adolescent Patients With BRAF V600 Mutation Positive Low Grade Glioma (LGG) or Relapsed or Refractory High Grade Glioma (HGG)	Active, not recruiting	NCT02684058	Phase 2	dabrafenib;trametinib;Carboplatin with vincristine

Search NIH Clinical Center for Central Neurocytoma

Cochrane evidence based reviews: neurocytoma

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Genetic Tests for Central Neurocytoma

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Anatomical Context for Central Neurocytoma

Organs/tissues related to Central Neurocytoma:

MalaCards : Brain, Spinal Cord, Medulla Oblongata, Occipital Lobe, Temporal Lobe, Cerebellum, Ovary

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Publications for Central Neurocytoma

Articles related to Central Neurocytoma:

(show top 50) (show all 484)

#	Title	Authors	PMID	Year
1	Synaptophysin negative central neurocytoma. ⁵³ ⁶²	Rychly B...Galbavy S	20429311	2010
2	Central neurocytoma: a clinical, radiological and pathological study of nine cases. ⁵³ ⁶²	Chen CL...Lee HT	18022760	2008
3	OLIG2 is a useful immunohistochemical marker in differential diagnosis of clear cell primary CNS neoplasms. ⁵³ ⁶²	Preusser M...Hainfellner JA	17257132	2007
4	Pigmented central neurocytoma. ⁵³ ⁶²	Kiehl TR...Louis DN	14991386	2004
5	Forskolin promotes astroglial differentiation of human central neurocytoma cells. ⁵³ ⁶²	Kim BJ...Suh-Kim H	15031671	2004
6	So-called malignant and extra-ventricular neurocytomas: reality or wrong diagnosis? A critical review about two overdiagnosed cases. ⁵³ ⁶²	Vallat-Decouvelaere AV...Hassoun J	11083081	2000
7	alpha-Synuclein is expressed in a variety of brain tumors showing neuronal differentiation. ⁵³ ⁶²	Kawashima M...Iwaki T	10672322	2000
8	Central neurocytoma with malignant course. Neuronal and glial differentiation and craniospinal dissemination. ⁵³ ⁶²	Elek G...Balint K	10393370	1999
9	Neuronal and glial characteristics of central neurocytoma: electron microscopical analysis of two cases. ⁵³ ⁶²	Tsuchida T...Kawamoto K	8781655	1996
10	Immunocytochemical detection of calcineurin and microtubule-associated protein 2 in central neurocytoma. ⁵³ ⁶²	Goto S...Fukui M	8410138	1993
11	Cytoskeletal immunohistochemistry of central neurocytomas. ⁵³ ⁶²	Hessler RB...VandenBerg SR	1471723	1992
12	Central neurocytoma: immunohistochemical and ultrastructural study. ⁵³ ⁶²	Kubota T...Tsunoda S	2028745	1991
13	Patterns of differentiation in central neurocytoma. An immunohistochemical study of eleven biopsies. ⁵³ ⁶²	von Deimling A...Wiestler OD	2109481	1990
14	Clinical application of 3D Slicer combined with Sina/MosoCam multimodal system in preoperative planning of brain lesions surgery. ⁶²	Zhou L...Cai Q	36357434	2022
15	Comparison of surgery with or without adjuvant radiotherapy in treating central neurocytoma: a single-center retrospective real-world study. ⁶²	She L...Liu C	36307664	2022
16	The role of single fraction Gamma Knife radiosurgery for intraventricular central neurocytomas and the utility of F-18 fluroethyltyrosine: two case reports. ⁶²	Dedeciusova M...Tuleasca C	36437467	2022
17	Diffuse GFAP Immunopositivity in the Oligodendrocyte-like Component of Pilocytic Astrocytoma Distinguishes It from Mimickers. ⁶²	Alturkustani M	35885538	2022
18	Uncommon Glioneuronal Tumors: A Radiologic and Pathologic Synopsis. ⁶²	Vaz A...de Almeida Teixeira BC	35512827	2022
19	A 22-Year Course of a Case with Central Neurocytoma. ⁶²	Shah A...Goel A	35864706	2022
20	TTF-1: A Well-Favored Addition to the Immunohistochemistry Armamentarium as a Diagnostic Marker of SEGA. ⁶²	Dutta R...Kale SS	34871801	2022
21	Malignant transformation of central neurocytoma with dissemination 17 years after initial treatment: illustrative case. ⁶²	Kojima K...Miyamoto S	36130558	2022
22	Clinical Outcomes and Prognostic Analysis of 101 Patients of Central Neurocytoma: A 10-Year Treatment Experience at a Single Institution. ⁶²	Xie Q...Wei R	35692765	2022
23	Central Neurocytoma with Hemorrhagic Presentation Case Report and Review of the Literature. ⁶²	Alsadiq MN...Aldahmen AA	35310930	2022
24	The Diagnostic Value of Pan-Trk Expression to Detect Neurotrophic Tyrosine Receptor Kinase (NTRK) Gene Fusion in CNS Tumours: A Study Using Next-Generation Sequencing Platform. ⁶²	Mohamed F...Fdl-Elmula I	35295612	2022
25	Extraventricular Neurocytoma: Clinical Investigation of Heterogenous Prognosis. ⁶²	Byun J...Kim JH	35118844	2022
26	A Clinicopathological and Molecular Analysis of Sellar/Suprasellar Neurocytoma Mimicking Pituitary Adenoma. ⁶²	Zhang L...Wang X	35663322	2022
27	Gamma Knife radiosurgery for the treatment of central neurocytoma: a single-institution experience of 25 patients. ⁶²	Akyoldas G...Peker S	33733378	2021
28	The importance of staged surgery for giant atypical central neurocytoma. ⁶²	Chaves JPG...Maeda AK	32857303	2021
29	MRI features of an atypical case of extraventricular neurocytoma: A case report. ⁶²	Liu X...Cheng J	34941079	2021
30	Lateral ventricular liponeurocytoma: Review of literature and case illustration. ⁶²	Al-Umran MR...Alotaibi FA	33766564	2021
31	Differential Diagnosis of Central Neurocytoma: Two Cases. ⁶²	Steinsiepe VK...Fournier JY	33352608	2021
32	Organic bipolar disorder secondary to central neurocytoma resection: a case report. ⁶²	Alberdi-Paramo I...Servan Rendon-Luna B	34533207	2021
33	Impact of Adjuvant Radiotherapy in Patients with Central Neurocytoma: A Multicentric International Analysis. ⁶²	Samhouri L...Eich HT	34503124	2021
34	A Rare Case of Isolated Intraventricular Primary Central Nervous System Lymphoma in an 85-Year-Old Man. ⁶²	Khanna G...Patir R	34660383	2021
35	Transcortical Approach to Deep-Seated Intraventricular and Intra-axial Tumors Using a Tubular Retractor System: A Technical Note and Review of the Literature. ⁶²	Okasha M...Surash S	33321519	2021
36	Tumor Spheroids of an Aggressive Form of Central Neurocytoma Have Transit-Amplifying Progenitor Characteristics with Enhanced EGFR and Tumor Stem Cell Signaling. ⁶²	Shin HY...Paek SH	33972466	2021
37	Erratum to "Retraction notice to neuroimaging diagnosis of intraventricular Central neurocytoma" [Neurosci. Lett. 735, 14 September (2020) 135143]. ⁶²	Jia L...Gao F	33551320	2021
38	Atypical Central Neurocytoma: An Investigation of Prognostic Factors. ⁶²	AbdelBari Mattar M...Toson EA	33091649	2021
39	Clinico-radiological characteristics, histo-pathological features and long-term survival outcomes in central neurocytoma: A single-institutional audit. ⁶²	Pawar D...Gupta T	33358093	2021
40	[Central neurocytomas: long-term treatment outcomes]. ⁶²	Konovalov AN...Antipina NA	33864664	2021
41	A rare diagnosis of an extraventricular neurocytoma. ⁶²	Gaggiotti C...Maugeri R	33767892	2021
42	Corpus Callosum Swelling after Resection of Intraventricular Central Neurocytoma. ⁶²	Aburakawa D...Tominaga T	35079514	2021
43	Clinical Outcome After Microsurgical Resection of Central Neurocytoma: A Single-Centre Analysis of 15 Years. ⁶²	Cao D...Chen J	35002932	2021
44	Refined Temporal-to-Frontal Horn Shunt for Treatment of Trapped Temporal Horn After Surgery of Peri- or Intraventricular Tumor: A Case Series Study. ⁶²	Ren X...Lin Z	34900736	2021
45	Immunohistochemical expression of Olig2, CD99, and EMA to differentiate oligodendroglial-like neoplasms. ⁶²	Kurdi M...Eberhart C	34628794	2021
46	The last decade's experience of management of central neurocytomas: Treatment strategies and new options. ⁶²	Konovalov A...Dalechina A	34345477	2021
47	Central neurocytoma originating in third ventricle with expansion into the cerebral aqueduct and fourth ventricle: Case report and review of literature. ⁶²	Ferrigno BW...Killory BD	32502563	2020
48	Antibiotic-induced black hairy tongue: two case reports and a review of the literature. ⁶²	Ren J...Yang Q	33044871	2020
49	Neuroimaging diagnosis of intraventricular Central neurocytoma. ⁶²	Jia L...Gao F	32544597	2020
50	Cerebellar Neurocytoma with Excellent Response to Radiotherapy. ⁶²	Chen S...Huang Y	32593767	2020

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Genes for Central Neurocytoma

Genes related to Central Neurocytoma (0 elite genes):

(show all 15)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence	PubMed IDs
1	SYP	Synaptophysin	Protein Coding	37.5	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	20429311 1471723 2028745 (more) 8410138 12507133 2109481 1370756 14991386 8781655 10451427 1615372 17167646 17039400 18022760 8287627 9591724 11083081
2	GFAP	Glial Fibrillary Acidic Protein	Protein Coding	31.85	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	10451427 17039400 1471723 (more) 10393370 17257132
3	MAP2	Microtubule Associated Protein 2	Protein Coding	23.79	DISEASES inferred ¹⁴ Novoseek inferred ⁵³ GeneCards inferred via : Publications (show sections)	12605092 1471723 11589429 (more) 8410138
4	OLIG2	Oligodendrocyte Transcription Factor 2	Protein Coding	15.28	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	17257132
5	NES	Nestin	Protein Coding	10.2	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	15031671
6	FGF2	Fibroblast Growth Factor 2	Protein Coding	9.97	DISEASES inferred ¹⁴ GeneCards inferred via : Publications (show sections)
7	CHGA	Chromogranin A	Protein Coding	8.96	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	1370756
8	ENO2	Enolase 2	Protein Coding	6.95	DISEASES inferred ¹⁴
9	NUDT6	Nudix Hydrolase 6	Protein Coding	6.94	GeneCards inferred via : Publications (show sections)
10	SNCA	Synuclein Alpha	Protein Coding	6.38	DISEASES inferred ¹⁴ Novoseek inferred ⁵³	10672322 10850861
11	RBFOX3	RNA Binding Fox-1 Homolog 3	Protein Coding	6.34	DISEASES inferred ¹⁴
12	OR14C36	Olfactory Receptor Family 14 Subfamily C Member 36	Protein Coding	6.03	DISEASES inferred ¹⁴
13	IDH1	Isocitrate Dehydrogenase (NADP(+)) 1	Protein Coding	5.79	DISEASES inferred ¹⁴
14	SCGN	Secretagogin, EF-Hand Calcium Binding Protein	Protein Coding	5.48	DISEASES inferred ¹⁴
15	KIAA1549	KIAA1549	Protein Coding	5.46	DISEASES inferred ¹⁴

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Variations for Central Neurocytoma

Copy number variations for Central Neurocytoma from CNVD:

⁶ (show top 50) (show all 66)

#	CNVD ID	Chromosome	Start	End	Type	Gene Symbol	CNVD Disease
1	13818	1	1	7200000	Loss		Neurocytoma
2	13819	1	1	7200000	Loss	CDK11B	Central neurocytomas
3	32215	1	34600000	40100000	Loss		Neurocytoma
4	32216	1	34600000	40100000	Loss	MYCL	Central neurocytomas
5	42690	10	38000000	42300000	Loss		Central neurocytomas
6	42691	10	38000000	42300000	Loss		Neurocytoma
7	47057	10	89500000	92900000	Gain		Neurocytoma
8	47162	10	89623194	89728532	Gain	PTEN	Central neurocytomas
9	48339	11	1	2800000	Loss		Neurocytoma
10	48340	11	1	2800000	Loss	HRAS	Central neurocytomas
11	49707	11	110400000	121200000	Gain		Neurocytoma
12	49709	11	110400000	121200000	Gain	KMT2A	Central neurocytomas
13	51786	11	130800000	135006516	Gain		Central neurocytomas
14	51787	11	130800000	135006516	Gain		Neurocytoma
15	54397	11	43500000	48800000	Gain		Neurocytoma
16	54398	11	43500000	48800000	Gain	CD82	Central neurocytomas
17	61830	12	101673905	101685205	Loss	UTP20	Central neurocytomas
18	61836	12	101786902	101801572	Loss	ARL1	Central neurocytomas
19	73747	12	96200000	109000000	Loss		Neurocytoma
20	74691	13	110300000	115169878	Loss		Central neurocytomas
21	74693	13	110300000	115169878	Loss		Neurocytoma
22	77106	13	40100000	55300000	Loss		Neurocytoma
23	77107	13	40100000	55300000	Loss	RB1	Central neurocytomas
24	81625	14	104000000	107349540	Gain		Neurocytoma
25	81627	14	104000000	107349540	Gain	IGH	Central neurocytomas
26	89768	15	19000000	33600000	Gain		Neurocytoma
27	90822	15	23985488	24185809	Gain		Central neurocytomas
28	90905	15	25700000	28100000	Loss		Neurocytoma
29	90906	15	25700000	28100000	Loss	SNRPN	Central neurocytomas
30	96486	15	89100000	102531392	Loss		Central neurocytomas
31	105389	16	79200000	81700000	Loss		Neurocytoma
32	105390	16	79200000	81700000	Loss	FRA16D	Central neurocytomas
33	106531	16	88700000	90354753	Gain		Neurocytoma
34	106838	17	1	3300000	Loss		Neurocytoma
35	30472	1	243700000	249250621	Gain	OR14C36	Central neurocytomas
36	30471	1	243700000	249250621	Gain		Neurocytoma
37	106839	17	1	3300000	Loss	HIC1	Central neurocytomas
38	106841	17	1	3300000	Loss	PAFAH1B1	Central neurocytomas
39	109411	17	25800000	38100000	Loss		Neurocytoma
40	112094	17	37856253	37884915	Loss	ERBB2	Central neurocytomas
41	112175	17	38100000	50200000	Loss		Neurocytoma
42	112177	17	38100000	50200000	Loss	BRCA1	Central neurocytomas
43	115446	17	57600000	62600000	Loss		Neurocytoma
44	115447	17	57600000	62600000	Loss	RPS6KB1	Central neurocytomas
45	133735	19	6900000	13900000	Loss		Neurocytoma
46	133738	19	6900000	13900000	Loss	ZNF439	Central neurocytomas
47	135912	2	122400000	129900000	Loss		Neurocytoma
48	136164	2	127805598	127864903	Loss	BIN1	Central neurocytomas
49	140117	2	19200000	24000000	Gain		Neurocytoma
50	140118	2	19200000	24000000	Gain	MYCN	Central neurocytomas

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Expression for Central Neurocytoma

Search GEO for disease gene expression data for Central Neurocytoma.

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Pathways for Central Neurocytoma

Pathways related to Central Neurocytoma according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Neuroscience ³	12.03	SYP SNCA SCGN RBFOX3 MAP2 GFAP
2	Neural crest differentiation ⁷⁴	11.34	OLIG2 GFAP FGF2
3	Neural Stem Cells and Lineage-specific Markers ⁶⁵	11	SYP OLIG2 NES MAP2 GFAP FGF2

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GO Terms for Central Neurocytoma

Biological processes related to Central Neurocytoma according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	negative regulation of microtubule polymerization	GO:0031115	9.26	MAP2 SNCA
2	negative regulation of neuron death	GO:1901215	9.1	SNCA ENO2 CHGA

Sources

Sources for Central Neurocytoma

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: CNT019 MIFTS: 44	Central Neurocytoma Categories: Cancer diseases, Eye diseases, Mental diseases, Neuronal diseases, Rare diseases	Data Licensing For inquiries, contact: [email protected]
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