MCID: CNT068
MIFTS: 30

Central Pain Syndrome

Categories: Cancer diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Central Pain Syndrome

MalaCards integrated aliases for Central Pain Syndrome:

Name: Central Pain Syndrome 53 54 72
Thalamic Hyperesthetic Anesthesia 53
Posterior Thalamic Syndrome 53
Central Post-Stroke Pain 53
Dejerine Roussy Syndrome 53
Retrolenticular Syndrome 53
Dejerine-Roussy Syndrome 72
Thalamic Pain Syndrome 53
Thalamic Syndrome 53

Classifications:



External Ids:

UMLS 72 C0221057 C1536114

Summaries for Central Pain Syndrome

NINDS : 54 Central pain syndrome is a neurological condition caused by damage to or dysfunction of the central nervous system (CNS), which includes the brain, brainstem, and spinal cord. This syndrome can be caused by stroke, multiple sclerosis, tumors, epilepsy, brain or spinal cord trauma, or Parkinson's disease. The character of the pain associated with this syndrome differs widely among individuals partly because of the variety of potential causes. Central pain syndrome may affect a large portion of the body or may be more restricted to specific areas, such as hands or feet. The extent of pain is usually related to the cause of the CNS injury or damage. Pain is typically constant, may be moderate to severe in intensity, and is often made worse by touch, movement, emotions, and temperature changes, usually cold temperatures. Individuals experience one or more types of pain sensations, the most prominent being burning. Mingled with the burning may be sensations of "pins and needles;" pressing, lacerating, or aching pain; and brief, intolerable bursts of sharp pain similar to the pain caused by a dental probe on an exposed nerve. Individuals may have numbness in the areas affected by the pain. The burning and loss of touch sensations are usually most severe on the distant parts of the body, such as the feet or hands. Central pain syndrome often begins shortly after the causative injury or damage, but may be delayed by months or even years, especially if it is related to post-stroke pain.

MalaCards based summary : Central Pain Syndrome, also known as thalamic hyperesthetic anesthesia, is related to sturge-weber syndrome and stroke, ischemic, and has symptoms including chronic pain, acute onset pain and pain, not elsewhere classified. An important gene associated with Central Pain Syndrome is CACNA1G (Calcium Voltage-Gated Channel Subunit Alpha1 G). The drugs Pregabalin and Calcium have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and cortex.

NIH Rare Diseases : 53 Central pain syndrome (CPS) is a rare neurological disorder caused by damage to or dysfunction of the pain-conducting pathways of the central nervous system (in the brain, brainstem, and spinal cord). Symptoms of CPS can vary greatly from one person to another, partly because the cause may differ. Primary symptoms are pain and loss of sensation, usually in the face, arms, and/or legs. Pain or discomfort may be felt after being touched, or even in the absence of a trigger. The pain may worsen by exposure to heat or cold and by emotional distress. CPS is usually associated with stroke, multiple sclerosis, tumors, epilepsy, brain or spinal cord trauma, or Parkinson's disease. Treatment typically includes pain medications, but complete relief of pain may not be possible. Tricyclic antidepressants or anticonvulsants can sometimes be useful. Lowering stress levels appears to reduce pain. Many different names have been used for this disorder, including Dejerine-Roussy syndrome, thalamic pain syndrome, central post-stroke syndrome and others. The current name acknowledges that damage to various areas of the central nervous system can cause central pain, and that a stroke is not necessarily the cause. When CPS is due to a stroke, it may be referred to as the more specific term "central post-stroke pain."

Wikipedia : 75 Central pain syndrome is a neurological condition consisting of constant, moderate to severe pain due to... more...

Related Diseases for Central Pain Syndrome

Diseases in the Chronic Pain family:

Paine Syndrome Central Pain Syndrome

Diseases related to Central Pain Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 57)
# Related Disease Score Top Affiliating Genes
1 sturge-weber syndrome 11.2
2 stroke, ischemic 10.7
3 cerebrovascular disease 10.7
4 allergic hypersensitivity disease 10.3
5 carotid artery occlusion 10.2
6 spasticity 10.2
7 ataxia and polyneuropathy, adult-onset 10.2
8 aceruloplasminemia 10.2
9 anosognosia 10.2
10 conversion disorder 10.2
11 plexopathy 10.2
12 neuropathy 10.1
13 diabetes insipidus 10.1
14 spinal cord injury 10.1
15 hemiplegia 10.0
16 erythermalgia, primary 10.0
17 lipomatosis, multiple 10.0
18 pain agnosia 10.0
19 pleomorphic lipoma 10.0
20 mood disorder 10.0
21 middle cerebral artery infarction 10.0
22 radiculopathy 10.0
23 dystonia 10.0
24 peripheral nervous system disease 10.0
25 48,xyyy 10.0
26 paresthesia 10.0
27 chronic pain 9.9
28 aphasia 9.8
29 encephalomalacia 9.8
30 vasculitis 9.8
31 hypopituitarism 9.8
32 facial neuralgia 9.8
33 cranial neuralgia 9.8
34 creutzfeldt-jakob disease 9.7
35 ocular motor apraxia 9.7
36 rheumatic heart disease 9.7
37 cerebral artery occlusion 9.7
38 arteriovenous malformation 9.7
39 vertebrobasilar insufficiency 9.7
40 epilepsy 9.7
41 mutism 9.7
42 akinetic mutism 9.7
43 intracranial embolism 9.7
44 acquired immunodeficiency syndrome 9.7
45 measles 9.7
46 meningitis 9.7
47 toxoplasmosis 9.7
48 pontine hemorrhage 9.7
49 tuberculous meningitis 9.7
50 aneurysm 9.7

Graphical network of the top 20 diseases related to Central Pain Syndrome:



Diseases related to Central Pain Syndrome

Symptoms & Phenotypes for Central Pain Syndrome

UMLS symptoms related to Central Pain Syndrome:


chronic pain, acute onset pain, pain, not elsewhere classified

Drugs & Therapeutics for Central Pain Syndrome

Drugs for Central Pain Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 27)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
2
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
3 Central Nervous System Depressants Phase 4
4 Tranquilizing Agents Phase 4
5 Hormones Phase 4
6 Psychotropic Drugs Phase 4
7 Anti-Anxiety Agents Phase 4
8 Anticonvulsants Phase 4
9 calcium channel blockers Phase 4
10 Calcium, Dietary Phase 4
11
Acetylcholine Approved, Investigational Phase 2 51-84-3 187
12 Peripheral Nervous System Agents Phase 2
13 Neuromuscular Agents Phase 2
14 abobotulinumtoxinA Phase 2
15 Cholinergic Agents Phase 2
16 Acetylcholine Release Inhibitors Phase 2
17 Neurotransmitter Agents Phase 2
18 Botulinum Toxins Phase 2
19 incobotulinumtoxinA Phase 2
20 Botulinum Toxins, Type A Phase 2
21
Lidocaine Approved, Vet_approved 137-58-6 3676
22 Anesthetics, Local
23 Sodium Channel Blockers
24 Diuretics, Potassium Sparing
25 Anesthetics
26 Anti-Arrhythmia Agents
27 Analgesics

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 A 13-Week, Randomized, Multi-Center, Double-Blind, Placebo-Controlled, Parallel-Group Study To Evaluate The Efficacy, Safety And Tolerability Of Pregabalin (150-600 Mg/Day) Using A Flexible Dosing Schedule In The Treatment Of Subjects With Central Post-Stroke Pain (CPSP) Completed NCT00313820 Phase 4 Pregabalin;Placebo
2 An Asian, Multicenter, Randomized, Double-blind, Placebo-controlled, 14-week Study of Mirogabalin in Participants With Central Neuropathic Pain Followed by a 52-week, Open-label Extension Recruiting NCT03901352 Phase 3 Placebo;Mirogabalin
3 A Prospective, Randomized, Double Blind, Crossover, Multi-center Study to Evaluate the Safety and the Efficacy of Motor Cortex Stimulation With the Cortical Stimulation Lead Model 2976 in Patients With Neuropathic Pain Terminated NCT00122915 Phase 3
4 Botulinum Toxin A for the Treatment of Chemotherapy Induced Peripheral Neuropathy Not yet recruiting NCT03571334 Phase 2 IncobotulinumtoxinA (Xeomin®, Merz) (INA);Normal saline
5 How "Central" is Central Post-stroke Pain? Investigating the Role of Peripheral Sensory Input in Maintaining Central Pain Completed NCT02148588 Ultrasound-guided peripheral nerve block with 2% lidocaine
6 Pain After Stroke, Part 2: Clinical Characteristics and Classification of Pain in Patients After Stroke Completed NCT00957697
7 Central Post-Stroke Pain - a Prospective Study of Consecutively Admitted Patients With Recent Stroke Completed NCT00957645
8 Efficacy of Navigated Repetitive Transcranial Magnetic Stimulation in Treatment of Central Post Stroke Pain Completed NCT02277912
9 Deep Brain Stimulation for Thalamic Pain Syndrome Completed NCT01072656
10 Comparison of the Analgesic Effects of Two Methods of Repetitive Magnetic Transcranial Stimulation: A Randomized Double Blind Sham Controlled Study in Patients With Central Neuropathic Pain Recruiting NCT03370107

Search NIH Clinical Center for Central Pain Syndrome

Genetic Tests for Central Pain Syndrome

Anatomical Context for Central Pain Syndrome

MalaCards organs/tissues related to Central Pain Syndrome:

41
Brain, Spinal Cord, Cortex, Thalamus, Eye, Heart, Bone

Publications for Central Pain Syndrome

Articles related to Central Pain Syndrome:

(show top 50) (show all 163)
# Title Authors PMID Year
1
Central post-stroke pain: clinical characteristics, pathophysiology, and management. 6
19679277 2009
2
Psychological morbidity and chronic disease among adults with nontraumatic spinal cord injuries: a cohort study of privately insured beneficiaries. 38
31153961 2019
3
Para median thalamic syndrome due to occlusion of the artery of Percheron: A rare case of stroke 38
31055905 2019
4
Traumatic brain injury, dry eye and comorbid pain diagnoses in US veterans. 38
28844048 2018
5
Fragile X syndrome: An overview and update of the FMR1 gene. 38
28617938 2018
6
Evidence that dry eye is a comorbid pain condition in a U.S. veteran population. 38
29392243 2017
7
Transplantation of spinal cord-derived neural stem cells for ALS: Analysis of phase 1 and 2 trials. 38
27358335 2016
8
Nociceptive transmission and modulation via P2X receptors in central pain syndrome. 38
27230068 2016
9
[Spinal cord stimulation for thalamic pain: Case report and review of the current literature]. 38
26491023 2016
10
Reduction of central neuropathic pain with ketamine infusion in a patient with Ehlers-Danlos syndrome: a case report. 38
27695362 2016
11
Bilateral Paramedian Thalamic Syndrome After Infection. 38
26260994 2015
12
A [14C]iodoantipyrine study of inter-regional correlations of neural substrates following central post-stroke pain in rats. 38
25889278 2015
13
Motor cortex stimulation in patients with chronic central pain. 38
25931362 2015
14
Red ear syndrome: literature review and a pediatric case report. 38
25583087 2015
15
Bilateral paramedian thalamic syndrome after infection. 38
25693586 2015
16
Excitatory and inhibitory brain metabolites as targets of motor cortex transcranial direct current stimulation therapy and predictors of its efficacy in fibromyalgia. 38
25371383 2015
17
The Efficacy of Gabapentin in Patients with Central Post-stroke Pain. 38
26185510 2015
18
Aromatase inhibition exacerbates pain and reactive gliosis in the dorsal horn of the spinal cord of female rats caused by spinothalamic tract injury. 38
25105782 2014
19
Pain in fibromyalgia and related conditions. 38
24938199 2014
20
A comprehensive, multispecialty approach to an acute exacerbation of chronic central pain in a tetraplegic. 38
24513720 2014
21
Cognitive and behavioral deficits following bilateral thalamic stroke: a longitudinal study. 38
23980818 2014
22
Development and pharmacological verification of a new mouse model of central post-stroke pain. 38
24055601 2014
23
Neuropathic pain following spinal cord injury: what we know about mechanisms, assessment and management. 38
24338470 2013
24
Estradiol attenuates spinal cord injury-induced pain by suppressing microglial activation in thalamic VPL nuclei of rats. 38
23419864 2013
25
Role of microglia and astrocyte in central pain syndrome following electrolytic lesion at the spinothalamic tract in rats. 38
22722907 2013
26
'Distorteidolias' - fantastic perceptive distortion. A new, pure dorsomedial thalamic syndrome. 38
23652461 2013
27
Thalamic syndrome as the heralding manifestation of atlantoaxial dislocation. 38
23314448 2013
28
Transdermal buprenorphine controls central neuropathic pain. 38
23264319 2012
29
[Neuroepithelial thalamo-mesencephalic cyst]. 38
22030167 2012
30
Acute cavernous sinus syndrome from metastasis of lung cancer to sphenoid bone. 38
22379475 2012
31
Improved dexterity after chronic electrical stimulation of the motor cortex for central pain: a special relevance for thalamic syndrome. 38
22922460 2012
32
[Analgesic effects of cannabinoids on central pain syndrome]. 38
22359935 2011
33
Motor cortex stimulation reduces hyperalgesia in an animal model of central pain. 38
21396776 2011
34
Acupuncture as adjuvant therapy in thalamic syndrome: case report. 38
21334511 2011
35
Acute disseminated encephalomyelitis: a long-term prospective study and meta-analysis. 38
21445814 2010
36
Surgical and hardware complications of deep brain stimulation. A seven-year experience and review of the literature. 38
20658301 2010
37
Operculo-insular pain (parasylvian pain): a distinct central pain syndrome. 38
20724291 2010
38
Abnormal activity of primary somatosensory cortex in central pain syndrome. 38
20660417 2010
39
Abnormal anterior pretectal nucleus activity contributes to central pain syndrome. 38
20357063 2010
40
[Efficacy of traditional herbal medicine, Yokukansan on patients with neuropathic pain]. 38
19860227 2009
41
Characteristics of patients with chronic pain accessing treatment with medical cannabis in Washington State. 38
19947069 2009
42
[Déjerine-Roussy syndrome of an ischaemic origin in an adolescent with patent foramen ovale]. 38
19557696 2009
43
Zona incerta: a role in central pain. 38
19403748 2009
44
Development and characterization of a hemorrhagic rat model of central post-stroke pain. 38
19324079 2009
45
Maladaptive homeostatic plasticity in a rodent model of central pain syndrome: thalamic hyperexcitability after spinothalamic tract lesions. 38
19005061 2008
46
Familial Creutzfeldt-Jakob Disease with a codon 200 mutation presenting as thalamic syndrome: diagnosis by single photon emission computed tomography using (99m)Tc-ethyl cysteinate dimer. 38
18176009 2008
47
Central pain syndrome: elucidation of genesis and treatment. 38
17997698 2007
48
Intrathecal baclofen in the treatment of post-stroke central pain, dystonia, and persistent vegetative state. 38
17691381 2007
49
Motor cortex stimulation for central pain following a traumatic brain injury. 38
16616421 2006
50
Role of cannabinoid receptor agonists in mechanisms of suppression of central pain syndrome. 38
17369898 2006

Variations for Central Pain Syndrome

Expression for Central Pain Syndrome

Search GEO for disease gene expression data for Central Pain Syndrome.

Pathways for Central Pain Syndrome

GO Terms for Central Pain Syndrome

Sources for Central Pain Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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