MCID: CNT068
MIFTS: 28

Central Pain Syndrome

Categories: Cancer diseases, Mental diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Central Pain Syndrome

MalaCards integrated aliases for Central Pain Syndrome:

Name: Central Pain Syndrome 54 55 74
Thalamic Hyperesthetic Anesthesia 54
Posterior Thalamic Syndrome 54
Central Post-Stroke Pain 54
Dejerine Roussy Syndrome 54
Retrolenticular Syndrome 54
Dejerine-Roussy Syndrome 74
Thalamic Pain Syndrome 54
Thalamic Syndrome 54

Classifications:



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Summaries for Central Pain Syndrome

NINDS : 55 Central pain syndrome is a neurological condition caused by damage to or dysfunction of the central nervous system (CNS), which includes the brain, brainstem, and spinal cord. This syndrome can be caused by stroke, multiple sclerosis, tumors, epilepsy, brain or spinal cord trauma, or Parkinson's disease. The character of the pain associated with this syndrome differs widely among individuals partly because of the variety of potential causes. Central pain syndrome may affect a large portion of the body or may be more restricted to specific areas, such as hands or feet. The extent of pain is usually related to the cause of the CNS injury or damage. Pain is typically constant, may be moderate to severe in intensity, and is often made worse by touch, movement, emotions, and temperature changes, usually cold temperatures. Individuals experience one or more types of pain sensations, the most prominent being burning. Mingled with the burning may be sensations of "pins and needles;" pressing, lacerating, or aching pain; and brief, intolerable bursts of sharp pain similar to the pain caused by a dental probe on an exposed nerve. Individuals may have numbness in the areas affected by the pain. The burning and loss of touch sensations are usually most severe on the distant parts of the body, such as the feet or hands. Central pain syndrome often begins shortly after the causative injury or damage, but may be delayed by months or even years, especially if it is related to post-stroke pain.

MalaCards based summary : Central Pain Syndrome, also known as thalamic hyperesthetic anesthesia, is related to sturge-weber syndrome and conversion disorder, and has symptoms including chronic pain, acute onset pain and pain, not elsewhere classified. An important gene associated with Central Pain Syndrome is CACNA1G (Calcium Voltage-Gated Channel Subunit Alpha1 G). The drugs Pregabalin and Calcium have been mentioned in the context of this disorder. Affiliated tissues include brain, spinal cord and cortex.

NIH Rare Diseases : 54 Central pain syndrome (CPS) is a rare neurological disorder caused by damage to or dysfunction of the pain-conducting pathways of the central nervous system (in the brain, brainstem, and spinal cord). Symptoms of CPS can vary greatly from one person to another, partly because the cause may differ. Primary symptoms are pain and loss of sensation, usually in the face, arms, and/or legs. Pain or discomfort may be felt after being touched, or even in the absence of a trigger. The pain may worsen by exposure to heat or cold and by emotional distress. CPS is usually associated with stroke, multiple sclerosis, tumors, epilepsy, brain or spinal cord trauma, or Parkinson's disease. Treatment typically includes pain medications, but complete relief of pain may not be possible. Tricyclic antidepressants or anticonvulsants can sometimes be useful. Lowering stress levels appears to reduce pain. Many different names have been used for this disorder, including Dejerine-Roussy syndrome, thalamic pain syndrome, central post-stroke syndrome and others. The current name acknowledges that damage to various areas of the central nervous system can cause central pain, and that a stroke is not necessarily the cause. When CPS is due to a stroke, it may be referred to as the more specific term "central post-stroke pain."

Wikipedia : 77 Central pain syndrome is a neurological condition consisting of constant, moderate to severe pain due to... more...

Related Diseases for Central Pain Syndrome

Diseases in the Paine Syndrome family:

Central Pain Syndrome Pain - Chronic

Diseases related to Central Pain Syndrome via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 19)
# Related Disease Score Top Affiliating Genes
1 sturge-weber syndrome 11.1
2 conversion disorder 10.2
3 stroke, ischemic 10.2
4 allergic hypersensitivity disease 10.2
5 ischemia 10.1
6 erythermalgia, primary 9.9
7 lipomatosis, multiple 9.9
8 pleomorphic lipoma 9.9
9 dystonia 9.9
10 neuropathy 9.9
11 depression 9.9
12 paresthesia 9.9
13 creutzfeldt-jakob disease 9.7
14 rheumatic heart disease 9.7
15 heart disease 9.7
16 intracranial embolism 9.7
17 toxoplasmosis 9.7
18 cerebral aneurysms 9.7
19 oligodendroglioma 9.7

Graphical network of the top 20 diseases related to Central Pain Syndrome:



Diseases related to Central Pain Syndrome

Symptoms & Phenotypes for Central Pain Syndrome

UMLS symptoms related to Central Pain Syndrome:


chronic pain, acute onset pain, pain, not elsewhere classified

Drugs & Therapeutics for Central Pain Syndrome

Drugs for Central Pain Syndrome (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 12)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Pregabalin Approved, Illicit, Investigational Phase 4 148553-50-8 5486971
2
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
3 Tranquilizing Agents Phase 4
4 Peripheral Nervous System Agents Phase 4
5 Calcium, Dietary Phase 4
6 Psychotropic Drugs Phase 4
7 Central Nervous System Depressants Phase 4
8 Analgesics Phase 4,Not Applicable
9 Anti-Anxiety Agents Phase 4
10 Hormones Phase 4
11 calcium channel blockers Phase 4
12 Anticonvulsants Phase 4

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Effect of Preventional Drug Therapy on Pain Regulation Mechanisms Among SCI Recruiting NCT03748290 Phase 4 Pregabalin;Placebo Oral Tablet
2 Motor Cortex Stimulation for the Treatment of Chronic Facial, Upper Extremity, and Throat Pain. Terminated NCT02321566 Phase 1
3 Long-term Effect of Motor Cortex Stimulation in Patients Suffering From Chronic Neuropathic Pain Completed NCT03189823
4 Comparison of rTMS and H Coil in Neuropathic Pain Recruiting NCT03370107 Not Applicable

Search NIH Clinical Center for Central Pain Syndrome

Genetic Tests for Central Pain Syndrome

Anatomical Context for Central Pain Syndrome

MalaCards organs/tissues related to Central Pain Syndrome:

42
Brain, Spinal Cord, Cortex, Heart

Publications for Central Pain Syndrome

Articles related to Central Pain Syndrome:

(show all 12)
# Title Authors Year
1
Nociceptive transmission and modulation via P2X receptors in central pain syndrome. ( 27230068 )
2016
2
Role of microglia and astrocyte in central pain syndrome following electrolytic lesion at the spinothalamic tract in rats. ( 22722907 )
2013
3
Abnormal anterior pretectal nucleus activity contributes to central pain syndrome. ( 20357063 )
2010
4
Abnormal activity of primary somatosensory cortex in central pain syndrome. ( 20660417 )
2010
5
Operculo-insular pain (parasylvian pain): a distinct central pain syndrome. ( 20724291 )
2010
6
Maladaptive homeostatic plasticity in a rodent model of central pain syndrome: thalamic hyperexcitability after spinothalamic tract lesions. ( 19005061 )
2008
7
Central pain syndrome: elucidation of genesis and treatment. ( 17997698 )
2007
8
Role of cannabinoid receptor agonists in mechanisms of suppression of central pain syndrome. ( 17369898 )
2006
9
Role of 5-HT3 receptors in the mechanisms of central pain syndrome. ( 12937671 )
2003
10
Hemihyperaesthesia and hyperresponsiveness resembling central pain syndrome in a dog with a forebrain oligodendroglioma. ( 11098380 )
2000
11
Central pain syndrome with manifestations in the foot. ( 9610051 )
1998
12
Central pain syndrome; a review of the literature and a case report. ( 13558179 )
1958

Variations for Central Pain Syndrome

Expression for Central Pain Syndrome

Search GEO for disease gene expression data for Central Pain Syndrome.

Pathways for Central Pain Syndrome

GO Terms for Central Pain Syndrome

Sources for Central Pain Syndrome

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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