MCID: CNT028
MIFTS: 41

Central Retinal Artery Occlusion

Categories: Blood diseases, Cardiovascular diseases, Eye diseases

Aliases & Classifications for Central Retinal Artery Occlusion

MalaCards integrated aliases for Central Retinal Artery Occlusion:

Name: Central Retinal Artery Occlusion 12 15 73

Classifications:



External Ids:

Disease Ontology 12 DOID:13098
ICD10 33 H34.1
ICD9CM 35 362.31
MeSH 44 D015356
NCIt 50 C34456
SNOMED-CT 68 38742007
UMLS 73 C0007688

Summaries for Central Retinal Artery Occlusion

Disease Ontology : 12 A retinal artery occlusion characterized by blockage of blood flow through the central retinal artery.

MalaCards based summary : Central Retinal Artery Occlusion is related to retinal vascular occlusion and carotid artery dissection. An important gene associated with Central Retinal Artery Occlusion is HMOX1 (Heme Oxygenase 1), and among its related pathways/superpathways are Senescence and Autophagy in Cancer and Cell adhesion_ECM remodeling. The drugs Ranibizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and retina.

Wikipedia : 76 Central retinal artery occlusion (CRAO) is a disease of the eye where the flow of blood through the... more...

Related Diseases for Central Retinal Artery Occlusion

Diseases in the Retinal Artery Occlusion family:

Central Retinal Artery Occlusion

Diseases related to Central Retinal Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
# Related Disease Score Top Affiliating Genes
1 retinal vascular occlusion 32.0 FANCG PLG
2 carotid artery dissection 30.3 PLAT PLG
3 arteries, anomalies of 30.0 PLAT PLG
4 retinal ischemia 11.6
5 retinal artery occlusion 11.3
6 branch retinal artery occlusion 10.9
7 optic nerve disease 10.6
8 neuropathy 10.6
9 temporal arteritis 10.5
10 churg-strauss syndrome 10.4
11 allergic angiitis 10.4
12 ischemic optic neuropathy 10.3
13 lupus erythematosus 10.3
14 systemic lupus erythematosus 10.3
15 nonarteritic anterior ischemic optic neuropathy 10.3
16 retinal vein occlusion 10.3
17 ischemia 10.3
18 vasculitis 10.3
19 sickle cell disease 10.3
20 stroke, ischemic 10.2
21 lymphoma 10.2
22 neovascular glaucoma 10.2
23 central retinal vein occlusion 10.2
24 herpes zoster 10.2
25 susac syndrome 10.2
26 polyarteritis nodosa, childhood-onset 10.1
27 orbital cellulitis 10.1
28 antiphospholipid syndrome 10.1
29 cellulitis 10.1
30 polyarteritis nodosa 10.1
31 eosinophilic granulomatosis with polyangiitis 10.1
32 herpes zoster ophthalmicus 10.1
33 ligneous conjunctivitis 10.1 PLAT PLG
34 intracranial embolism 10.1 PLAT PLG
35 inferior myocardial infarction 10.1 PLAT PLG
36 occlusion precerebral artery 10.1 PLAT PLG
37 basilar artery occlusion 10.1 PLAT PLG
38 acute cor pulmonale 10.1 PLAT PLG
39 acute pulmonary heart disease 10.1 PLAT PLG
40 fibromuscular dysplasia 10.1
41 macular dystrophy, dominant cystoid 10.1
42 myocardial infarction 10.1
43 paroxysmal nocturnal hemoglobinuria 10.1
44 thrombosis 10.1
45 patent foramen ovale 10.1
46 essential thrombocythemia 10.1
47 protein s deficiency 10.1
48 carotid artery disease 10.1
49 macular retinal edema 10.1
50 hemoglobinuria 10.1

Comorbidity relations with Central Retinal Artery Occlusion via Phenotypic Disease Network (PDN):


Hypertension, Essential Ischemic Heart Disease

Graphical network of the top 20 diseases related to Central Retinal Artery Occlusion:



Diseases related to Central Retinal Artery Occlusion

Symptoms & Phenotypes for Central Retinal Artery Occlusion

Drugs & Therapeutics for Central Retinal Artery Occlusion

Drugs for Central Retinal Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 4,Not Applicable 347396-82-1 459903
2 Angiogenesis Inhibitors Phase 4,Not Applicable
3 Angiogenesis Modulating Agents Phase 4,Not Applicable
4 Immunologic Factors Phase 4,Not Applicable
5 Insulin, Globin Zinc Phase 4
6 insulin Phase 4
7
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
8
Salicylic acid Approved, Investigational, Vet_approved Phase 3 69-72-7 338
9
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
10
Acetazolamide Approved, Vet_approved Phase 3 59-66-5 1986
11 Plasminogen Phase 3
12 Anti-Inflammatory Agents, Non-Steroidal Phase 3
13 Analgesics Phase 3
14 Cyclooxygenase Inhibitors Phase 3
15 Tissue Plasminogen Activator Phase 3
16 Analgesics, Non-Narcotic Phase 3
17 Antirheumatic Agents Phase 3
18 Pharmaceutical Solutions Phase 3
19 Anti-Inflammatory Agents Phase 3
20 Peripheral Nervous System Agents Phase 3
21 Fibrinolytic Agents Phase 3
22 Platelet Aggregation Inhibitors Phase 3
23 Antipyretics Phase 3
24 diuretics Phase 3
25 Adrenergic Antagonists Phase 3
26 Anticoagulants Phase 3
27 Anticonvulsants Phase 3
28 calcium heparin Phase 3
29 Adrenergic beta-Antagonists Phase 3
30 Carbonic Anhydrase Inhibitors Phase 3
31 Adrenergic Agents Phase 3
32 Neurotransmitter Agents Phase 3
33 Natriuretic Agents Phase 3
34
Melphalan Approved Not Applicable 148-82-3 4053 460612
35
Mechlorethamine Approved, Investigational Not Applicable 51-75-2 4033
36 alanine Not Applicable
37 Immunosuppressive Agents Not Applicable
38 Nitrogen Mustard Compounds Not Applicable
39 phenylalanine Not Applicable
40 Antineoplastic Agents, Alkylating Not Applicable
41 Alkylating Agents Not Applicable

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Influence of Diabetes Control on Treatment of Diabetic Macular Edema With Ranibizumab Recruiting NCT02665689 Phase 4 ranibizumab
2 A Phase III Randomized, Blind, Double Dummy, Multicenter Study Assessing the Efficacy and Safety of IV THrombolysis (Alteplase) in Patients With acutE Central retInal Artery Occlusion Recruiting NCT03197194 Phase 3 Alteplase;acetylsalicylic acid;Placebo Oral Tablet;placebo IV
3 EAGLE - Multicenter Study of the European Assessment Group for Lysis in the Eye Terminated NCT00637468 Phase 3 Intravenous injection of heparin;Intravenous injection of acetazolamide;Topical use of beta-blocker;Isovolaemic haemodilution;Acetylsalicylic acid
4 The Effect of Transcorneal Stimulation in Cases of Central Retinal Artery Occlusion Using a New Waveform Unknown status NCT00802698 Phase 1, Phase 2
5 Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye Unknown status NCT01348633
6 Intra-arterial Melphalan in Treating Younger Patients With Unilateral Retinoblastoma Completed NCT02097134 Not Applicable Melphalan
7 Intravitreal Ranibizumab in Exudative Age-related Macular Degeneration With Posterior Vitreomacular Adhesion Completed NCT01291121 Not Applicable
8 Study of Arterial Recanalization of the Central Retinal Artery Occlusions Recruiting NCT03049514
9 Pre and Post-arterial Recanalization Imaging of Central Retinal Artery Occlusions (CRAO) Recruiting NCT03313817
10 Philadelphia Telemedicine Glaucoma Detection and Follow-Up Study Active, not recruiting NCT02390245 Not Applicable
11 Hyperbaric Oxygen Therapy Registry Enrolling by invitation NCT02483650

Search NIH Clinical Center for Central Retinal Artery Occlusion

Genetic Tests for Central Retinal Artery Occlusion

Anatomical Context for Central Retinal Artery Occlusion

MalaCards organs/tissues related to Central Retinal Artery Occlusion:

41
Eye, Brain, Retina, Lung, T Cells, Bone, Heart

Publications for Central Retinal Artery Occlusion

Articles related to Central Retinal Artery Occlusion:

(show top 50) (show all 549)
# Title Authors Year
1
Central Retinal Artery Occlusion with Cilioretinal Artery sparing; imaging by smartphone. ( 29921543 )
2018
2
Bilateral central retinal artery occlusion as presenting manifestation of human immunodeficiency virus infection. ( 29480272 )
2018
3
Central retinal artery occlusion following orbital biopsy. ( 29664557 )
2018
4
Calcified amorphous tumor: A rare cause of central retinal artery occlusion. ( 29780907 )
2018
5
Intra-Arterial Thrombolysis for Acute Central Retinal Artery Occlusion: A Systematic Review and Meta-Analysis. ( 29527185 )
2018
6
Atypical central retinal artery occlusion as the first presentation of POEMS syndrome: a case report. ( 29739345 )
2018
7
Central retinal artery occlusion secondary to Barlow's disease. ( 29780944 )
2018
8
Central retinal artery occlusion during vitrectomy: Immediate retinal revascularization following induction of posterior vitreous detachment. ( 29468216 )
2018
9
Treatment of Nonarteritic Acute Central Retinal Artery Occlusion. ( 29717825 )
2018
10
Optic nerve avulsion associated with central retinal artery occlusion following rotational globe injury. ( 29941768 )
2018
11
Clinical presentation of multiple cerebral emboli and central retinal artery occlusion (CRAO) as signs of cardiac myxoma. ( 29942186 )
2018
12
Erratum: Intra-Arterial Thrombolytic Therapy Is Not a Therapeutic Option for Filler-Related Central Retinal Artery Occlusion. ( 29763939 )
2018
13
MULTIMODAL IMAGING IN A CASE OF CENTRAL RETINAL ARTERY OCCLUSION IN THE PRESENCE OF TYPE 2 MACULAR TELANGIECTASIA. ( 29905668 )
2018
14
Current treatment of central retinal artery occlusion: a national survey. ( 29236169 )
2018
15
Central Retinal Artery Occlusion with Sparing of Cilioretinal Artery Post Pulmonary Artery Stenting. ( 29607276 )
2018
16
Intra-Arterial Thrombolytic Therapy Is Not a Therapeutic Option for Filler-Related Central Retinal Artery Occlusion. ( 29378380 )
2018
17
Thrombus in Lamina Cribrosa Seen Using Swept-Source Optical Coherence Tomography in Eye With Central Retinal Artery Occlusion. ( 29360684 )
2018
18
Optical coherence tomography (OCT) angiography of central retinal artery occlusion in the patent cilioretinal artery: a case report. ( 29924197 )
2018
19
Central retinal artery occlusion - rethinking retinal survival time. ( 29669523 )
2018
20
Ophthalmic artery MRI in an arteritis-related central retinal artery occlusion. ( 29358510 )
2018
21
Intravenous thrombolysis in acute central retinal artery occlusion - A prospective interventional case series. ( 29813111 )
2018
22
Ischemic Stroke Risk in Medicare Beneficiaries with Central Retinal Artery Occlusion: A Retrospective Cohort Study. ( 29574676 )
2018
23
Central retinal artery occlusion showing features of paracentral acute middle maculopathy following uncomplicated pterygium surgery. ( 29962106 )
2018
24
Management of central retinal artery occlusion following successful hyperbaric oxygen therapy: case report. ( 29571239 )
2018
25
Bilateral central retinal artery occlusion from catastrophic antiphospholipid syndrome. ( 30420561 )
2018
26
Intra-retinal Arterial Cannulation using a Microneedle for Central Retinal Artery Occlusion. ( 29358594 )
2018
27
Central retinal artery occlusion and traumatic optic neuropathy following blunt ocular trauma. ( 29862194 )
2018
28
Retinal Endovascular Surgery with Tissue Plasminogen Activator Injection for Central Retinal Artery Occlusion. ( 30022948 )
2018
29
Central Retinal Artery Occlusion Due to Intraorbital Ophthalmic Artery Aneurysm. ( 30052553 )
2018
30
Is Management of Central Retinal Artery Occlusion the Next Frontier in Cerebrovascular Diseases? ( 30060907 )
2018
31
Optical Coherence Tomography Measurement and Visual Outcome in Acute Central Retinal Artery Occlusion. ( 30091309 )
2018
32
Amalric triangular sign in a case of central retinal artery occlusion combined with posterior ciliary artery occlusion - Case report. ( 30094393 )
2018
33
CENTRAL RETINAL ARTERY OCCLUSION WITH CILIORETINAL ARTERY SPARING AFTER LASER-ASSISTED IN SITU KERATOMILEUSIS. ( 30106799 )
2018
34
Stroke Risk and Risk Factors in Patients With Central Retinal Artery Occlusion. ( 30153430 )
2018
35
Central retinal artery occlusion in a young child secondary to resistance to activated protein C. ( 30217606 )
2018
36
Central Retinal Artery Occlusion Following Hyaluronic Acid Fillers Injection. ( 30219170 )
2018
37
Effect of hyperbaric oxygen treatment in central retinal artery occlusion. ( 30241121 )
2018
38
Hyperbaric oxygen therapy in the treatment of central retinal artery occlusion. ( 30260139 )
2018
39
Urgent Evaluation of the Patient With Acute Central Retinal Artery Occlusion. ( 30286941 )
2018
40
Central retinal artery occlusion on postoperative day one after vitreoretinal surgery. ( 30364763 )
2018
41
Central retinal artery occlusion as an onset form of Takayasu's arteritis. ( 30424934 )
2018
42
Central retinal artery occlusion. ( 30451166 )
2018
43
Is Management of Central Retinal Artery Occlusion the Next Frontier in Cerebrovascular Diseases? ( 30529221 )
2018
44
Neurofibromatosis Type 1 Vasculopathy Presenting as Impending Central Retinal Artery Occlusion. ( 30540635 )
2018
45
Fusiform Left Carotid-Ophthalmic Artery Aneurysm Presenting with Central Retinal Artery Occlusion. ( 27865695 )
2017
46
Update on the Management of Central Retinal Artery Occlusion. ( 27886897 )
2017
47
Transient central retinal artery occlusion after sub-tenon's anaesthesia: Is it a safe technique? ( 28755793 )
2017
48
The Penumbra Obscura Stimulates Iris Neovascularisation after Isolated Central Retinal Artery Occlusion. ( 28367049 )
2017
49
Bilateral Central Retinal Artery Occlusion Associated with Bilateral Lymphoproliferative Infiltrative Optic Neuropathy. ( 29071274 )
2017
50
Cystoid Macular Edema with Idiopathic Acute Central Retinal Artery Occlusion in a Healthy Child. ( 28791072 )
2017

Variations for Central Retinal Artery Occlusion

Expression for Central Retinal Artery Occlusion

Search GEO for disease gene expression data for Central Retinal Artery Occlusion.

Pathways for Central Retinal Artery Occlusion

Pathways related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.39 AMBRA1 PLAT
2 11.11 PLAT PLG
3 10.95 PLAT PLG
4 10.84 PLAT PLG
5 10.32 PLAT PLG
6 9.74 PLAT PLG

GO Terms for Central Retinal Artery Occlusion

Cellular components related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 ACTA2 HMOX1 PLAT PLG SERPINA10

Biological processes related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.5 AMBRA1 HMOX1 PLG
2 regulation of blood pressure GO:0008217 9.26 ACTA2 HMOX1
3 hemostasis GO:0007599 9.16 PLG SERPINA10
4 blood coagulation GO:0007596 9.13 PLAT PLG SERPINA10
5 fibrinolysis GO:0042730 8.62 PLAT PLG

Sources for Central Retinal Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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