MCID: CNT028
MIFTS: 41

Central Retinal Artery Occlusion

Categories: Blood diseases, Cardiovascular diseases, Eye diseases

Aliases & Classifications for Central Retinal Artery Occlusion

MalaCards integrated aliases for Central Retinal Artery Occlusion:

Name: Central Retinal Artery Occlusion 12 15 74

Classifications:



External Ids:

Disease Ontology 12 DOID:13098
ICD9CM 36 362.31
MeSH 45 D015356
NCIt 51 C34456
SNOMED-CT 69 38742007
ICD10 34 H34.1
UMLS 74 C0007688

Summaries for Central Retinal Artery Occlusion

Disease Ontology : 12 A retinal artery occlusion characterized by blockage of blood flow through the central retinal artery.

MalaCards based summary : Central Retinal Artery Occlusion is related to retinal artery occlusion and retinal vascular occlusion. An important gene associated with Central Retinal Artery Occlusion is HMOX1 (Heme Oxygenase 1), and among its related pathways/superpathways are Senescence and Autophagy in Cancer and Cell adhesion_ECM remodeling. The drugs Ranibizumab and Angiogenesis Inhibitors have been mentioned in the context of this disorder. Affiliated tissues include eye, brain and retina.

Wikipedia : 77 Central retinal artery occlusion (CRAO) is a disease of the eye where the flow of blood through the... more...

Related Diseases for Central Retinal Artery Occlusion

Diseases in the Retinal Artery Occlusion family:

Central Retinal Artery Occlusion

Diseases related to Central Retinal Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 139)
# Related Disease Score Top Affiliating Genes
1 retinal artery occlusion 32.3 ACTA2 HMOX1
2 retinal vascular occlusion 32.1 FANCG PLG
3 carotid artery dissection 30.3 PLAT PLG
4 arteries, anomalies of 29.9 PLAT PLG
5 retinal ischemia 11.6
6 branch retinal artery occlusion 10.8
7 optic nerve disease 10.6
8 neuropathy 10.6
9 churg-strauss syndrome 10.4
10 allergic angiitis 10.4
11 ischemic optic neuropathy 10.3
12 lupus erythematosus 10.3
13 systemic lupus erythematosus 10.3
14 nonarteritic anterior ischemic optic neuropathy 10.3
15 retinal vein occlusion 10.3
16 lymphoma 10.3
17 neovascular glaucoma 10.3
18 ischemia 10.3
19 herpes zoster 10.3
20 vasculitis 10.3
21 sickle cell disease 10.3
22 stroke, ischemic 10.2
23 polyarteritis nodosa, childhood-onset 10.2
24 central retinal vein occlusion 10.2
25 polyarteritis nodosa 10.2
26 herpes zoster ophthalmicus 10.2
27 susac syndrome 10.2
28 orbital cellulitis 10.2
29 antiphospholipid syndrome 10.2
30 cellulitis 10.2
31 ligneous conjunctivitis 10.1 PLAT PLG
32 intracranial embolism 10.1 PLAT PLG
33 inferior myocardial infarction 10.1 PLAT PLG
34 occlusion precerebral artery 10.1 PLAT PLG
35 basilar artery occlusion 10.1 PLAT PLG
36 acute cor pulmonale 10.1 PLAT PLG
37 acute pulmonary heart disease 10.1 PLAT PLG
38 intermediate coronary syndrome 10.1 PLAT PLG
39 fibromuscular dysplasia 10.1
40 macular dystrophy, dominant cystoid 10.1
41 myocardial infarction 10.1
42 paroxysmal nocturnal hemoglobinuria 10.1
43 thrombosis 10.1
44 patent foramen ovale 10.1
45 essential thrombocythemia 10.1
46 protein s deficiency 10.1
47 carotid artery disease 10.1
48 macular retinal edema 10.1
49 hemoglobinuria 10.1
50 homocystinuria 10.1

Comorbidity relations with Central Retinal Artery Occlusion via Phenotypic Disease Network (PDN):


Hypertension, Essential Ischemic Heart Disease

Graphical network of the top 20 diseases related to Central Retinal Artery Occlusion:



Diseases related to Central Retinal Artery Occlusion

Symptoms & Phenotypes for Central Retinal Artery Occlusion

Drugs & Therapeutics for Central Retinal Artery Occlusion

Drugs for Central Retinal Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 41)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Ranibizumab Approved Phase 4,Not Applicable 347396-82-1 459903
2 Angiogenesis Inhibitors Phase 4,Not Applicable
3 Angiogenesis Modulating Agents Phase 4,Not Applicable
4 Insulin, Globin Zinc Phase 4
5 insulin Phase 4
6
Salicylic acid Approved, Investigational, Vet_approved Phase 3 69-72-7 338
7
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
8
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
9
Acetazolamide Approved, Vet_approved Phase 3 59-66-5 1986
10 Analgesics Phase 3
11 Tissue Plasminogen Activator Phase 3
12 Platelet Aggregation Inhibitors Phase 3
13 Antirheumatic Agents Phase 3
14 Analgesics, Non-Narcotic Phase 3
15 Pharmaceutical Solutions Phase 3
16 Anti-Inflammatory Agents, Non-Steroidal Phase 3
17 Antipyretics Phase 3
18 Plasminogen Phase 3
19 Cyclooxygenase Inhibitors Phase 3
20 Peripheral Nervous System Agents Phase 3
21 Anti-Inflammatory Agents Phase 3
22 Fibrinolytic Agents Phase 3
23 Adrenergic Antagonists Phase 3
24 calcium heparin Phase 3
25 Adrenergic beta-Antagonists Phase 3
26 Natriuretic Agents Phase 3
27 Carbonic Anhydrase Inhibitors Phase 3
28 Neurotransmitter Agents Phase 3
29 Anticonvulsants Phase 3
30 diuretics Phase 3
31 Adrenergic Agents Phase 3
32 Anticoagulants Phase 3
33
Mechlorethamine Approved, Investigational Not Applicable 51-75-2 4033
34
Melphalan Approved Not Applicable 148-82-3 460612 4053
35 alanine Not Applicable
36 Alkylating Agents Not Applicable
37 Immunologic Factors Not Applicable
38 Immunosuppressive Agents Not Applicable
39 Nitrogen Mustard Compounds Not Applicable
40 phenylalanine Not Applicable
41 Antineoplastic Agents, Alkylating Not Applicable

Interventional clinical trials:

(show all 11)
# Name Status NCT ID Phase Drugs
1 Influence of Diabetes Control on Treatment of Diabetic Macular Edema With Ranibizumab Recruiting NCT02665689 Phase 4 ranibizumab
2 A Phase III Randomized, Blind, Double Dummy, Multicenter Study Assessing the Efficacy and Safety of IV THrombolysis (Alteplase) in Patients With acutE Central retInal Artery Occlusion Recruiting NCT03197194 Phase 3 Alteplase;acetylsalicylic acid;Placebo Oral Tablet;placebo IV
3 EAGLE - Multicenter Study of the European Assessment Group for Lysis in the Eye Terminated NCT00637468 Phase 3 Intravenous injection of heparin;Intravenous injection of acetazolamide;Topical use of beta-blocker;Isovolaemic haemodilution;Acetylsalicylic acid
4 The Effect of Transcorneal Stimulation in Cases of Central Retinal Artery Occlusion Using a New Waveform Unknown status NCT00802698 Phase 1, Phase 2
5 Retinal Oxygen Saturation, Blood Flow, Vascular Function and High Resolution Morphometric Imaging in the Living Human Eye Unknown status NCT01348633
6 Intra-arterial Melphalan in Treating Younger Patients With Unilateral Retinoblastoma Completed NCT02097134 Not Applicable Melphalan
7 Intravitreal Ranibizumab in Exudative Age-related Macular Degeneration With Posterior Vitreomacular Adhesion Completed NCT01291121 Not Applicable
8 Study of Arterial Recanalization of the Central Retinal Artery Occlusions Recruiting NCT03049514
9 Pre and Post-arterial Recanalization Imaging of Central Retinal Artery Occlusions (CRAO) Recruiting NCT03313817
10 Philadelphia Telemedicine Glaucoma Detection and Follow-Up Study Active, not recruiting NCT02390245 Not Applicable
11 Hyperbaric Oxygen Therapy Registry Enrolling by invitation NCT02483650

Search NIH Clinical Center for Central Retinal Artery Occlusion

Genetic Tests for Central Retinal Artery Occlusion

Anatomical Context for Central Retinal Artery Occlusion

MalaCards organs/tissues related to Central Retinal Artery Occlusion:

42
Eye, Brain, Retina, Lung, T Cells

Publications for Central Retinal Artery Occlusion

Articles related to Central Retinal Artery Occlusion:

(show top 50) (show all 560)
# Title Authors Year
1
Stroke Risk and Risk Factors in Patients With Central Retinal Artery Occlusion. ( 30579615 )
2019
2
Visual field defects and changes in central retinal artery occlusion. ( 30605464 )
2019
3
Is Management of Central Retinal Artery Occlusion the Next Frontier in Cerebrovascular Diseases? ( 30612637 )
2019
4
Acute Vascular Ischemic Events in Patients with Central Retinal Artery Occlusion in the United States: A Nationwide Study 2003-2014. ( 30689989 )
2019
5
Central retinal artery occlusion - a new, provisional treatment approach. ( 30707925 )
2019
6
Stroke Risk Before and After Central Retinal Artery Occlusion in a US Cohort. ( 30711121 )
2019
7
Evaluation of the Association between the Risk of Central Retinal Artery Occlusion and the Concentration of Environmental Air Pollutants. ( 30736427 )
2019
8
Early Identification of Central Retinal Artery Occlusion Using Point-of-care Ultrasound. ( 30775656 )
2019
9
Herpes Zoster Ophthalmicus, Central Retinal Artery Occlusion, and Neovascular Glaucoma in an Immunocompetent Individual. ( 30820294 )
2019
10
Stroke Risk and Risk Factors in Patients With Central Retinal Artery Occlusion. ( 30827486 )
2019
11
Central Retinal Artery Occlusion with Cilioretinal Artery sparing; imaging by smartphone. ( 29921543 )
2018
12
Bilateral central retinal artery occlusion as presenting manifestation of human immunodeficiency virus infection. ( 29480272 )
2018
13
Central retinal artery occlusion following orbital biopsy. ( 29664557 )
2018
14
Calcified amorphous tumor: A rare cause of central retinal artery occlusion. ( 29780907 )
2018
15
Intra-Arterial Thrombolysis for Acute Central Retinal Artery Occlusion: A Systematic Review and Meta-Analysis. ( 29527185 )
2018
16
Atypical central retinal artery occlusion as the first presentation of POEMS syndrome: a case report. ( 29739345 )
2018
17
Central retinal artery occlusion secondary to Barlow's disease. ( 29780944 )
2018
18
Central retinal artery occlusion during vitrectomy: Immediate retinal revascularization following induction of posterior vitreous detachment. ( 29468216 )
2018
19
Treatment of Nonarteritic Acute Central Retinal Artery Occlusion. ( 29717825 )
2018
20
Optic nerve avulsion associated with central retinal artery occlusion following rotational globe injury. ( 29941768 )
2018
21
Clinical presentation of multiple cerebral emboli and central retinal artery occlusion (CRAO) as signs of cardiac myxoma. ( 29942186 )
2018
22
Erratum: Intra-Arterial Thrombolytic Therapy Is Not a Therapeutic Option for Filler-Related Central Retinal Artery Occlusion. ( 29763939 )
2018
23
MULTIMODAL IMAGING IN A CASE OF CENTRAL RETINAL ARTERY OCCLUSION IN THE PRESENCE OF TYPE 2 MACULAR TELANGIECTASIA. ( 29905668 )
2018
24
Current treatment of central retinal artery occlusion: a national survey. ( 29236169 )
2018
25
Central Retinal Artery Occlusion with Sparing of Cilioretinal Artery Post Pulmonary Artery Stenting. ( 29607276 )
2018
26
Intra-Arterial Thrombolytic Therapy Is Not a Therapeutic Option for Filler-Related Central Retinal Artery Occlusion. ( 29378380 )
2018
27
Thrombus in Lamina Cribrosa Seen Using Swept-Source Optical Coherence Tomography in Eye With Central Retinal Artery Occlusion. ( 29360684 )
2018
28
Optical coherence tomography (OCT) angiography of central retinal artery occlusion in the patent cilioretinal artery: a case report. ( 29924197 )
2018
29
Central retinal artery occlusion - rethinking retinal survival time. ( 29669523 )
2018
30
Ophthalmic artery MRI in an arteritis-related central retinal artery occlusion. ( 29358510 )
2018
31
Intravenous thrombolysis in acute central retinal artery occlusion - A prospective interventional case series. ( 29813111 )
2018
32
Ischemic Stroke Risk in Medicare Beneficiaries with Central Retinal Artery Occlusion: A Retrospective Cohort Study. ( 29574676 )
2018
33
Central retinal artery occlusion showing features of paracentral acute middle maculopathy following uncomplicated pterygium surgery. ( 29962106 )
2018
34
Management of central retinal artery occlusion following successful hyperbaric oxygen therapy: case report. ( 29571239 )
2018
35
Central retinal artery occlusion and traumatic optic neuropathy following blunt ocular trauma. ( 29862194 )
2018
36
Intra-retinal Arterial Cannulation using a Microneedle for Central Retinal Artery Occlusion. ( 29358594 )
2018
37
Bilateral central retinal artery occlusion from catastrophic antiphospholipid syndrome. ( 30420561 )
2018
38
Retinal Endovascular Surgery with Tissue Plasminogen Activator Injection for Central Retinal Artery Occlusion. ( 30022948 )
2018
39
Central Retinal Artery Occlusion Due to Intraorbital Ophthalmic Artery Aneurysm. ( 30052553 )
2018
40
Is Management of Central Retinal Artery Occlusion the Next Frontier in Cerebrovascular Diseases? ( 30060907 )
2018
41
Optical Coherence Tomography Measurement and Visual Outcome in Acute Central Retinal Artery Occlusion. ( 30091309 )
2018
42
Amalric triangular sign in a case of central retinal artery occlusion combined with posterior ciliary artery occlusion - Case report. ( 30094393 )
2018
43
CENTRAL RETINAL ARTERY OCCLUSION WITH CILIORETINAL ARTERY SPARING AFTER LASER-ASSISTED IN SITU KERATOMILEUSIS. ( 30106799 )
2018
44
Stroke Risk and Risk Factors in Patients With Central Retinal Artery Occlusion. ( 30153430 )
2018
45
Central retinal artery occlusion in a young child secondary to resistance to activated protein C. ( 30217606 )
2018
46
Central Retinal Artery Occlusion Following Hyaluronic Acid Fillers Injection. ( 30219170 )
2018
47
Effect of hyperbaric oxygen treatment in central retinal artery occlusion. ( 30241121 )
2018
48
Hyperbaric oxygen therapy in the treatment of central retinal artery occlusion. ( 30260139 )
2018
49
Urgent Evaluation of the Patient With Acute Central Retinal Artery Occlusion. ( 30286941 )
2018
50
Central retinal artery occlusion on postoperative day one after vitreoretinal surgery. ( 30364763 )
2018

Variations for Central Retinal Artery Occlusion

Expression for Central Retinal Artery Occlusion

Search GEO for disease gene expression data for Central Retinal Artery Occlusion.

Pathways for Central Retinal Artery Occlusion

Pathways related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.39 AMBRA1 PLAT
2 11.11 PLAT PLG
3 10.95 PLAT PLG
4 10.84 PLAT PLG
5 10.32 PLAT PLG
6 9.74 PLAT PLG

GO Terms for Central Retinal Artery Occlusion

Cellular components related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular space GO:0005615 9.02 ACTA2 HMOX1 PLAT PLG SERPINA10

Biological processes related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell proliferation GO:0008285 9.5 PLG HMOX1 AMBRA1
2 regulation of blood pressure GO:0008217 9.26 HMOX1 ACTA2
3 hemostasis GO:0007599 9.16 SERPINA10 PLG
4 blood coagulation GO:0007596 9.13 SERPINA10 PLG PLAT
5 fibrinolysis GO:0042730 8.62 PLG PLAT

Sources for Central Retinal Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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