MCID: CNT028
MIFTS: 42

Central Retinal Artery Occlusion

Categories: Blood diseases, Cardiovascular diseases, Eye diseases, Neuronal diseases

Aliases & Classifications for Central Retinal Artery Occlusion

MalaCards integrated aliases for Central Retinal Artery Occlusion:

Name: Central Retinal Artery Occlusion 12 15 70 32

Classifications:



External Ids:

Disease Ontology 12 DOID:13098
ICD9CM 34 362.31
MeSH 44 D015356
NCIt 50 C34456
SNOMED-CT 67 38742007
ICD10 32 H34.1
UMLS 70 C0007688

Summaries for Central Retinal Artery Occlusion

Disease Ontology : 12 A retinal artery occlusion characterized by blockage of blood flow through the central retinal artery.

MalaCards based summary : Central Retinal Artery Occlusion is related to neovascular glaucoma and orbital cellulitis. An important gene associated with Central Retinal Artery Occlusion is THY1 (Thy-1 Cell Surface Antigen), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Complement and coagulation cascades. The drugs Tenecteplase and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include eye, retina and brain, and related phenotypes are cardiovascular system and muscle

Wikipedia : 73 Central retinal artery occlusion (CRAO) is a disease of the eye where the flow of blood through the... more...

Related Diseases for Central Retinal Artery Occlusion

Diseases in the Retinal Artery Occlusion family:

Central Retinal Artery Occlusion

Diseases related to Central Retinal Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 503)
# Related Disease Score Top Affiliating Genes
1 neovascular glaucoma 31.1 VEGFA PLG CRYAA
2 orbital cellulitis 31.1 CRYAA CRP
3 carotid stenosis 31.0 VEGFA MTHFR CRP
4 retinal vascular disease 30.9 VEGFA PLG MTHFR CRYAA
5 carotid artery disease 30.9 PLG PLAT CRP
6 branch retinal artery occlusion 30.8 VEGFA SERPINC1 PRTN3 PLG MTHFR F2
7 microvascular complications of diabetes 5 30.8 VEGFA PLG CRYAA
8 macular holes 30.8 VEGFA PLG CRYAA
9 optic nerve disease 30.8 VEGFA EDN1 CRYAA CRP
10 mononeuritis multiplex 30.7 PRTN3 CRP
11 rubeosis iridis 30.7 VEGFA PLG
12 arteritic anterior ischemic optic neuropathy 30.6 MTHFR F2
13 retinal artery occlusion 30.6 VEGFA THY1 SERPINC1 PLG MTHFR HMOX1
14 granulomatous angiitis 30.4 PRTN3 CRP
15 intraocular pressure quantitative trait locus 30.4 VEGFA EDN1 CRYAA
16 vitreous detachment 30.3 VEGFA PLG
17 endocarditis 30.3 SERPINC1 PLAT F2 CRP
18 aortic valve insufficiency 30.3 F2 CRP ACTA2
19 hemopericardium 30.3 PLG F2 CRP
20 retinal vascular occlusion 30.3 VEGFA SERPINC1 PLG MTHFR F2 EDN1
21 central retinal vein occlusion 30.3 VEGFA SERPINC1 PLAT MTHFR F2
22 angioedema 30.3 PLG PLAT CRP
23 facial paralysis 30.2 PRTN3 PLG CRP
24 iritis 30.2 VEGFA CRP
25 protein s deficiency 30.2 SERPINC1 MTHFR F2
26 microvascular complications of diabetes 1 30.1 VEGFA EDN1 CRYAA
27 carotid artery thrombosis 30.1 SERPINC1 PLG PLAT
28 endophthalmitis 30.1 VEGFA PLG CRYAA CRP
29 thrombophilia 30.1 SERPINC1 PLAT MTHFR F2
30 ischemia 30.1 VEGFA PLG PLAT HMOX1 EDN1
31 cranial nerve palsy 30.1 SERPINC1 PRTN3 CRP
32 purpura 30.1 SERPINC1 F2 CRP
33 thrombocytosis 30.0 SERPINC1 F2 CRP
34 alpha-1-antitrypsin deficiency 30.0 SERPINC1 PRTN3 F2
35 arteriosclerosis 30.0 SERPINC1 HMOX1 EDN1 CRP
36 aortic aneurysm, familial abdominal, 1 30.0 SERPINC1 PLG CRP ACTA2
37 homocysteinemia 29.9 SERPINC1 MTHFR F2 CRP
38 retinal vein occlusion 29.9 VEGFA SERPINC1 MTHFR F2 EDN1
39 intracranial hypertension 29.9 SERPINC1 MTHFR F2
40 antiphospholipid syndrome 29.9 SERPINC1 PLAT MTHFR F2 CRP
41 stroke, ischemic 29.9 SERPINC1 PLG PLAT MTHFR F2 CRP
42 pericardial effusion 29.9 VEGFA PRTN3 F2 CRP
43 compartment syndrome 29.9 SERPINC1 PLG F2 CRP
44 macular degeneration, age-related, 1 29.9 VEGFA PLG HMOX1 CRYAA CRP
45 thrombosis 29.9 SERPINC1 PLG PLAT MTHFR F2
46 arteries, anomalies of 29.8 VEGFA PLG EDN1 CRP
47 papilledema 29.8 VEGFA SERPINC1 F2 CRP
48 glaucoma, primary open angle 29.8 VEGFA EDN1 CRYAA
49 livedoid vasculitis 29.8 SERPINC1 PLG MTHFR F2
50 thrombophilia due to activated protein c resistance 29.7 SERPINC1 PLG MTHFR F2

Comorbidity relations with Central Retinal Artery Occlusion via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Central Retinal Artery Occlusion:



Diseases related to Central Retinal Artery Occlusion

Symptoms & Phenotypes for Central Retinal Artery Occlusion

MGI Mouse Phenotypes related to Central Retinal Artery Occlusion:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.61 ACTA2 CRP EDN1 F2 HMOX1 PLAT
2 muscle MP:0005369 9.17 ACTA2 EDN1 F2 HMOX1 PLAT SERPINC1

Drugs & Therapeutics for Central Retinal Artery Occlusion

Drugs for Central Retinal Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 15)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Tenecteplase Approved Phase 3 191588-94-0
2
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
3
Salicylic acid Approved, Investigational, Vet_approved Phase 3 69-72-7 338
4 Analgesics, Non-Narcotic Phase 3
5 Analgesics Phase 3
6 Cyclooxygenase Inhibitors Phase 3
7 Fibrinolytic Agents Phase 3
8 Antirheumatic Agents Phase 3
9 Antipyretics Phase 3
10 Anti-Inflammatory Agents, Non-Steroidal Phase 3
11 Anti-Inflammatory Agents Phase 3
12 Platelet Aggregation Inhibitors Phase 3
13 Pharmaceutical Solutions Phase 3
14 Plasminogen Phase 3
15 Tissue Plasminogen Activator Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 TENecteplase in Central Retinal Artery Occlusion Study (TenCRAOS): A Randomized Placebo-controlled Trial of Early Systemic Tenecteplase Treatment in Patients With Central Retinal Artery Occlusion. Recruiting NCT04526951 Phase 3 Intravenous injection of Tenecteplase and one dose of placebo tablet;One tablet of Acetylsalicylic Acid and one dose of IV placebo
2 A Phase III Randomized, Blind, Double Dummy, Multicenter Study Assessing the Efficacy and Safety of IV THrombolysis (Alteplase) in Patients With acutE Central retInal Artery Occlusion Recruiting NCT03197194 Phase 3 Alteplase;acetylsalicylic acid;Placebo Oral Tablet;placebo IV
3 The Effect of Transcorneal Stimulation in Cases of Central Retinal Artery Occlusion Using a New Waveform Unknown status NCT00802698 Phase 1, Phase 2
4 Study of Arterial Recanalization of the Central Retinal Artery Occlusions Recruiting NCT03049514
5 Pre and Post-arterial Recanalization Imaging of Central Retinal Artery Occlusions (CRAO) Recruiting NCT03313817

Search NIH Clinical Center for Central Retinal Artery Occlusion

Genetic Tests for Central Retinal Artery Occlusion

Anatomical Context for Central Retinal Artery Occlusion

MalaCards organs/tissues related to Central Retinal Artery Occlusion:

40
Eye, Retina, Brain, Heart, Bone, Thyroid, Breast

Publications for Central Retinal Artery Occlusion

Articles related to Central Retinal Artery Occlusion:

(show top 50) (show all 1221)
# Title Authors PMID Year
1
Diagnostic Yield of Neck CT Angiography in Young Adults With Anterior Circulation Ischemic Stroke: A Community Based Study. 61
33791054 2021
2
The use of multimodal imaging in the evaluation of a patient with central retinal artery occlusion in the setting of asteroid hyalosis: a case report. 61
33794992 2021
3
[OCT-angiography and en-face OCT in paracentral acute middle maculopathy with perivenular ischemia associated with a central retinal artery occlusion]. 61
33637321 2021
4
Successfully treated hemi-central retinal artery occlusion following cardiac catheterization; case report. 61
33717472 2021
5
Optical coherence tomography-based determination of ischaemia onset - the temporal dynamics of retinal thickness increase in acute central retinal artery occlusion. 61
32767551 2021
6
Central Retinal Artery Occlusion Secondary to Giant Cell Arteritis With Normal Inflammatory Markers. 61
33657589 2021
7
Retrobulbar Spot Sign in Metachronous Bilateral Central Retinal Artery Occlusion of Cardioembolic Origin. 61
32282511 2021
8
Management of Central Retinal Artery Occlusion: A Scientific Statement From the American Heart Association. 61
33677974 2021
9
MULTIMODAL IMAGING IN A CASE OF CENTRAL RETINAL ARTERY OCCLUSION IN THE PRESENCE OF TYPE 2 MACULAR TELANGIECTASIA. 61
29905668 2021
10
Post COVID-19 Ophthalmic Manifestations in an Asian Indian Male. 61
33733987 2021
11
Central Retinal Artery Occlusion in Patients with COVID-19: Imaging for Underlying Causes. 61
33787341 2021
12
Performing hyperbaric oxygen therapy for central retinal artery occlusion under COVID-19: From myringotomy to rapid viral test. 61
33194540 2021
13
Usefulness of orbital colour Doppler ultrasound in vascular-related monocular vision loss. 61
33733967 2021
14
Case Report: Combined Ischemic Optic Neuropathy and Central Retinal Artery Occlusion after Starting Hemodialysis. 61
33633019 2021
15
Vascular Damage May Mimic Retinitis and Optic Neuritis in COVID-19. 61
33661715 2021
16
ACUTE RETINAL NECROSIS ASSOCIATED WITH HERPES ZOSTER VACCINATION. 61
30048403 2021
17
Retinal hypoxia and angiogenesis with methamphetamine. 61
33736986 2021
18
Management of Acute Central Retinal Artery Occlusion, a "Retinal Stroke": An Institutional Series and Literature Review. 61
33310593 2021
19
Monocular visual loss as the presenting symptom of COVID-19 infection. 61
33383464 2021
20
Paracentral acute middle maculopathy in the setting of central retinal artery occlusion following COVID-19 diagnosis. 61
33583231 2021
21
Intravitreal sirolimus for persistent, exudative age-related macular degeneration: a Pilot Study. 61
33593448 2021
22
Formation of Transient Retinal Folds Caused by Central Retinal Artery Occlusion After Vitrectomy for Macular Hole Closure. 61
33230069 2021
23
Diagnosing Central Retinal Artery Occlusion via Point-of-Care Ultrasound in the Emergency Department. 61
33579659 2021
24
Assessment of Trends in the Incidence Rates of Central Retinal Artery Occlusion in Korea From 2002 to 2015. 61
33570556 2021
25
Bilateral Central Retinal Artery Occlusion Secondary to SARS-CoV-2 Infection in the Early and Late Periods: A Case Report. 61
33607682 2021
26
[Intravenous fibrinolysis for nonarteritic central retinal artery occlusion-a treatment option?] 61
33559724 2021
27
Conservative treatments for acute nonarteritic central retinal artery occlusion: Do they work? 61
33767952 2021
28
Intra-Arterial Tissue Plasminogen Activator for Central Retinal Artery Occlusion. 61
33623361 2021
29
The actual role of thrombolytic treatment in central retinal artery occlusion. 61
33402310 2021
30
Central retinal artery occlusion as a neuro-ophthalmological emergency: the need to raise public awareness. 61
33452753 2021
31
A painless, sudden loss of vision in sickle cell anaemia: central retinal artery occlusion. 61
33388104 2021
32
Intraoperative Cycling Pressure Variation in the Treatment of Central Retinal Artery Occlusion. 61
33510922 2021
33
Intravenous Recombinant Tissue-Type Plasminogen Activator Thrombolysis for Acute Central Retinal Artery Occlusion. 61
33156166 2021
34
The Retrobulbar Spot Sign and Prominent Middle Limiting Membrane as Prognostic Markers in Non-Arteritic Retinal Artery Occlusion. 61
33477523 2021
35
Central retinal artery occlusion associated with Sweet syndrome. 61
33493459 2021
36
Should we prevent thrombosis related to intravenous immunoglobulin infusions with systematic anticoagulant prophylaxis? 61
32718469 2021
37
Rare cause of cardioembolic stroke and central retinal artery occlusion. 61
33461997 2021
38
The U.S. Veterans Health Administration national giant cell arteritis (GCA) database cohort: incident ophthalmic complications in biopsy-negative GCA patients. 61
33417014 2021
39
Transocular sonography in acute arterial occlusions of the eye in elderly patients: Diagnostic value of the spot sign. 61
33577572 2021
40
A Narrative Review of Common Uses of Ophthalmic Ultrasound in Emergency Medicine. 61
32919837 2021
41
Sudden painless loss of vision following spine surgery: lessons learnt in darkness. 61
33461994 2021
42
Endovascular surgery in the field of ophthalmology. 61
33161486 2021
43
Ocular side effects of novel anti-cancer biological therapies. 61
33436995 2021
44
Literature Commentary. 61
33666589 2020
45
Cumulative visual impact of two coagulability disorders: A case report. 61
33149782 2020
46
Differences in the multicolour imaging features between the superficial and deep vascular occlusions. 61
32737726 2020
47
Arteritic Orbital Ischemia Producing Afferent and Efferent Pupillary Defects. 61
31524841 2020
48
Post COVID Inflammation Syndrome: Different Manifestations Caused by the Virus. 61
33247640 2020
49
Rare case of orbital cellulitis resulting in visual loss due to central retinal artery occlusion. 61
32860263 2020
50
Normal to supernormal 30-Hz flicker ERGs predict visual function and prognosis in central retinal artery occlusion. 61
32506269 2020

Variations for Central Retinal Artery Occlusion

Expression for Central Retinal Artery Occlusion

Search GEO for disease gene expression data for Central Retinal Artery Occlusion.

Pathways for Central Retinal Artery Occlusion

Pathways related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

(show all 13)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.03 VEGFA SERPINC1 PRTN3 PLG PLAT F2
2 11.78 SERPINC1 PLG PLAT F2
3 11.71 VEGFA HMOX1 EDN1
4 11.7 VEGFA PLAT HMOX1 EDN1
5
Show member pathways
11.69 PLG PLAT MTHFR F2 CRP
6 11.42 VEGFA HMOX1 EDN1
7 11.27 VEGFA PLG PLAT
8 11.23 THY1 PLG PLAT
9
Show member pathways
11.22 SERPINC1 PRTN3 PLG PLAT F2
10
Show member pathways
10.81 VEGFA EDN1 CRP
11 10.8 HMOX1 CRP
12 10.77 VEGFA PLAT
13 10.57 PLG PLAT

GO Terms for Central Retinal Artery Occlusion

Cellular components related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.86 THY1 SERPINC1 PRTN3 PLG PLAT H3-4
2 extracellular region GO:0005576 9.81 VEGFA THY1 SERPINC1 PRTN3 PLG PLAT
3 collagen-containing extracellular matrix GO:0062023 9.35 SERPINC1 PRTN3 PLG PLAT F2
4 extracellular space GO:0005615 9.32 VEGFA SERPINC1 PRTN3 PLG PLAT HMOX1

Biological processes related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to hypoxia GO:0071456 9.65 VEGFA HMOX1 EDN1
2 regulation of blood pressure GO:0008217 9.5 HMOX1 EDN1 ACTA2
3 vasoconstriction GO:0042310 9.46 EDN1 CRP
4 regulation of blood coagulation GO:0030193 9.43 SERPINC1 F2
5 hemostasis GO:0007599 9.43 SERPINC1 PLG F2
6 negative regulation of cell-cell adhesion mediated by cadherin GO:2000048 9.4 VEGFA PLG
7 negative regulation of fibrinolysis GO:0051918 9.37 PLG F2
8 blood coagulation GO:0007596 9.35 SERPINC1 PRTN3 PLG PLAT F2
9 fibrinolysis GO:0042730 9.33 PLG PLAT F2
10 response to hypoxia GO:0001666 9.02 VEGFA PLAT MTHFR HMOX1 EDN1

Molecular functions related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 enzyme binding GO:0019899 9.56 THY1 PRTN3 PLG HMOX1
2 serine-type endopeptidase activity GO:0004252 9.46 PRTN3 PLG PLAT F2
3 signaling receptor binding GO:0005102 9.35 PRTN3 PLG PLAT F2 EDN1
4 serine-type peptidase activity GO:0008236 8.92 PRTN3 PLG PLAT F2

Sources for Central Retinal Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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