MCID: CNT028
MIFTS: 43

Central Retinal Artery Occlusion

Categories: Blood diseases, Cardiovascular diseases, Eye diseases

Aliases & Classifications for Central Retinal Artery Occlusion

MalaCards integrated aliases for Central Retinal Artery Occlusion:

Name: Central Retinal Artery Occlusion 12 15 71 32

Classifications:



External Ids:

Disease Ontology 12 DOID:13098
ICD9CM 34 362.31
MeSH 43 D015356
NCIt 49 C34456
SNOMED-CT 67 38742007
ICD10 32 H34.1
UMLS 71 C0007688

Summaries for Central Retinal Artery Occlusion

Disease Ontology : 12 A retinal artery occlusion characterized by blockage of blood flow through the central retinal artery.

MalaCards based summary : Central Retinal Artery Occlusion is related to retinal vascular disease and orbital cellulitis. An important gene associated with Central Retinal Artery Occlusion is HMOX1 (Heme Oxygenase 1), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and Folate Metabolism. The drugs Salicylic acid and Aspirin have been mentioned in the context of this disorder. Affiliated tissues include eye, heart and brain, and related phenotypes are cardiovascular system and immune system

Wikipedia : 74 Central retinal artery occlusion (CRAO) is a disease of the eye where the flow of blood through the... more...

Related Diseases for Central Retinal Artery Occlusion

Diseases in the Retinal Artery Occlusion family:

Central Retinal Artery Occlusion

Diseases related to Central Retinal Artery Occlusion via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 493)
# Related Disease Score Top Affiliating Genes
1 retinal vascular disease 30.9 VEGFA PLG CRYAA CRP
2 orbital cellulitis 30.8 RHNO1 CRYAA CRP
3 carotid stenosis 30.7 VEGFA LPA CRP
4 optic papillitis 30.7 CRP CD40LG
5 macular retinal edema 30.6 VEGFA PLG FANCG
6 microvascular complications of diabetes 5 30.6 VEGFA PLG CRYAA
7 exophthalmos 30.5 RHNO1 PRTN3 CRP
8 optic nerve disease 30.5 VEGFA CRYAA CRP CD40LG BLOC1S6
9 neuroretinitis 30.5 CRP CD40LG
10 vitreous detachment 30.5 VEGFA PLG PLAT
11 hemopericardium 30.4 PLG F2
12 granulomatous angiitis 30.3 PRTN3 CRP
13 carotid artery disease 30.3 PLG PLAT LPA CRP
14 mononeuritis multiplex 30.2 PRTN3 CRP CD40LG
15 meningitis 30.2 VEGFA CRP CD40LG
16 rubeosis iridis 30.1 VEGFA PLG FANCG
17 branch retinal artery occlusion 30.0 VEGFA SERPINC1 PLG FANCG F2 CRP
18 endophthalmitis 30.0 VEGFA PLG CRYAA CRP
19 migraine with or without aura 1 30.0 PLG F2 CRP CD40LG
20 panuveitis 30.0 VEGFA CRP CD40LG
21 homocysteinemia 29.9 SERPINC1 F2 CRP
22 granulomatosis with polyangiitis 29.9 PRTN3 CRP CD40LG
23 sickle cell anemia 29.9 HMOX1 F2 CD40LG
24 angioedema 29.9 PLG CRP CD40LG
25 retinal vein occlusion 29.9 VEGFA SERPINC1 F2 CD40LG
26 mononeuropathy 29.8 PRTN3 CRP CD40LG
27 henoch-schoenlein purpura 29.8 PRTN3 CRP CD40LG
28 heart valve disease 29.8 LPA F2 CRP
29 temporal arteritis 29.8 PRTN3 CRP CD40LG
30 retinal vascular occlusion 29.7 VEGFA SERPINC1 PLG LPA FANCG F2
31 thrombophilia due to thrombin defect 29.7 SERPINC1 PLAT F2
32 central retinal vein occlusion 29.7 VEGFA SERPINC1 PLG PLAT F2
33 carotid artery thrombosis 29.7 SERPINC1 PLG PLAT
34 arteries, anomalies of 29.7 VEGFA PLG PLAT LPA CRP
35 coronary heart disease 1 29.7 PLAT LPA CRP
36 arteriosclerosis 29.6 SERPINC1 LPA HMOX1 CRP
37 endocarditis 29.6 SERPINC1 PLAT F2 CRP
38 atherosclerosis susceptibility 29.6 VEGFA PLAT LPA CRP
39 nonarteritic anterior ischemic optic neuropathy 29.6 VEGFA SERPINC1 F2 CRP BLOC1S6
40 retinal artery occlusion 29.6 VEGFA THY1 SERPINC1 PLG HMOX1 FANCG
41 facial paralysis 29.6 PRTN3 PLG CRP CD40LG
42 eclampsia 29.5 VEGFA SERPINC1 F2
43 pericardial effusion 29.5 VEGFA F2 CRP CD40LG
44 thrombocytosis 29.5 SERPINC1 F2 CRP
45 cranial nerve palsy 29.5 RHNO1 PRTN3 CRP CD40LG
46 alpha-1-antitrypsin deficiency 29.3 SERPINC1 PRTN3 F2
47 eye disease 29.3 VEGFA PLG CRYAA CRP CD40LG
48 compartment syndrome 29.3 SERPINC1 PLG F2 CRP
49 atrial heart septal defect 29.3 SERPINC1 PLG PLAT F2 CRP
50 pneumonia 29.3 VEGFA HMOX1 F2 CRP CD40LG

Comorbidity relations with Central Retinal Artery Occlusion via Phenotypic Disease Network (PDN):


Hypertension, Essential

Graphical network of the top 20 diseases related to Central Retinal Artery Occlusion:



Diseases related to Central Retinal Artery Occlusion

Symptoms & Phenotypes for Central Retinal Artery Occlusion

MGI Mouse Phenotypes related to Central Retinal Artery Occlusion:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.85 ACTA2 BLOC1S6 CD40LG CRP F2 HMOX1
2 immune system MP:0005387 9.65 BLOC1S6 CD40LG CRP F2 HMOX1 PLAT
3 respiratory system MP:0005388 9.17 BLOC1S6 F2 HMOX1 PLAT PLG THY1

Drugs & Therapeutics for Central Retinal Artery Occlusion

Drugs for Central Retinal Artery Occlusion (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Salicylic acid Approved, Investigational, Vet_approved Phase 3 69-72-7 338
2
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
3
Acetazolamide Approved, Vet_approved Phase 3 59-66-5 1986
4
Heparin Approved, Investigational Phase 3 9005-49-6 772 46507594
5 Plasminogen Phase 3
6 Tissue Plasminogen Activator Phase 3
7 Anti-Inflammatory Agents Phase 3
8 Fibrinolytic Agents Phase 3
9 Cyclooxygenase Inhibitors Phase 3
10 Anti-Inflammatory Agents, Non-Steroidal Phase 3
11 Analgesics, Non-Narcotic Phase 3
12 Platelet Aggregation Inhibitors Phase 3
13 Antipyretics Phase 3
14 Antirheumatic Agents Phase 3
15 Analgesics Phase 3
16 Anticoagulants Phase 3
17 calcium heparin Phase 3
18 Carbonic Anhydrase Inhibitors Phase 3
19 Natriuretic Agents Phase 3
20 Anticonvulsants Phase 3
21 diuretics Phase 3

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Topical Timolol for the Treatment of Benign Vascular Periocular Lesions Withdrawn NCT01250457 Phase 4 topical Timolol
2 A Phase III Randomized, Blind, Double Dummy, Multicenter Study Assessing the Efficacy and Safety of IV THrombolysis (Alteplase) in Patients With acutE Central retInal Artery Occlusion Recruiting NCT03197194 Phase 3 Alteplase;acetylsalicylic acid;Placebo Oral Tablet;placebo IV
3 Multizenterstudie Der European Assessment Group for Lysis in the Eye (EAGLE) Zur Behandlung Des Zentralarterienverschlusses (ZAV): Lysetherapie Versus Konservative Therapie Terminated NCT00637468 Phase 3 Intravenous injection of heparin;Intravenous injection of acetazolamide;Topical use of beta-blocker;Isovolaemic haemodilution;Acetylsalicylic acid
4 The Effect of Transcorneal Stimulation in Cases of Central Retinal Artery Occlusion Using a New Waveform Unknown status NCT00802698 Phase 1, Phase 2
5 Study of Arterial Recanalization of the Central Retinal Artery Occlusions Recruiting NCT03049514
6 The Effect of Table Position on Intraocular Pressure (IOP) and Ocular Perfusion Pressure (OPP) During Prone Spine Surgery Terminated NCT00176722

Search NIH Clinical Center for Central Retinal Artery Occlusion

Genetic Tests for Central Retinal Artery Occlusion

Anatomical Context for Central Retinal Artery Occlusion

MalaCards organs/tissues related to Central Retinal Artery Occlusion:

40
Eye, Heart, Brain, Retina, Lung, Kidney, Bone

Publications for Central Retinal Artery Occlusion

Articles related to Central Retinal Artery Occlusion:

(show top 50) (show all 1100)
# Title Authors PMID Year
1
Demonstration of acute retinal ischemia on diffusion weighted magnetic resonance imaging. 61
31816539 2020
2
Thrombolytic Therapy for Acute Central Retinal Artery Occlusion. 61
31865896 2020
3
Clinical Manifestations and Visual Prognosis of Cilioretinal Artery Sparing Central Retinal Artery Occlusion. 61
32037747 2020
4
Retinal oedema in central retinal artery occlusion develops as a function of time. 61
32040258 2020
5
Development of visual acuity under hyperbaric oxygen treatment (HBO) in non arteritic retinal branch artery occlusion. 61
31863398 2020
6
[Central retinal artery occlusion and central retinal vein occlusion after severe contusive trauma: Multimodal imaging]. 61
31987675 2020
7
UNILATERAL OPTIC NEURITIS AND CENTRAL RETINAL VASCULITIS DUE TO OCULAR SYPHILIS. 61
28816862 2020
8
Distal radial access in the anatomical snuffbox for neurointerventions: a feasibility, safety, and proof-of-concept study. 61
31915209 2020
9
Using the Retrobulbar Spot Sign to Assist in Diagnosis and Management of Central Retinal Artery Occlusions. 61
31228289 2020
10
OPHTHALMIC VASCULAR EVENTS AFTER INTRA-ARTERIAL CHEMOTHERAPY FOR RETINOBLASTOMA: Real-World Comparison Between Primary and Secondary Treatments. 61
30204728 2019
11
Juvenile Central Retinal Artery Occlusion Associated With Atrial Septal Defect. 61
31821511 2019
12
Non artheritic bilateral anterior ischaemic optic neuropathy (NAION) as devastating complication following Total Hip Arthroplasty: a case report. 61
31910190 2019
13
Bartonella endocarditis masquerading as systemic vasculitis with rapidly progressive glomerulonephritis (aka 'Löhlein nephritis'). 61
31801777 2019
14
Prevalence of Atrial Fibrillation in Patients with Retinal Vessel Occlusion and Its Association: A Systematic Review and Meta-Analysis. 61
31283356 2019
15
Vision Loss Associated with Hyaluronic Acid Fillers: A Systematic Review of Literature. 61
31822960 2019
16
Central retinal artery occlusion in a child with angiolymphoid hyperplasia with eosinophilia orbit. 61
31755456 2019
17
Effect of vitrectomy with intrasurgical regulation of intraocular pressure in a rabbit model of central retinal artery occlusion. 61
31626799 2019
18
Retinal Artery and Vein Occlusions Successfully Treated with Hyperbaric Oxygen. 61
31763582 2019
19
Hypothermia protects retinal ganglion cells against hypoxia-induced cell death in a retina organ culture model. 61
31152487 2019
20
Idiopathic central retinal artery occlusion. 61
31693152 2019
21
Histopathology of retinoblastoma eyes enucleated after intra-arterial chemotherapy. 61
31676593 2019
22
Susac Syndrome: A Rare Case Report. 61
31599263 2019
23
[Central retinal artery occlusion secondary to pheochromocytoma]. 61
31182254 2019
24
Spontaneous Intra-orbital Arteriovenous Fistula: A Rare Cause of Proptosis. 61
31807372 2019
25
Ophthalmic and Central Retinal Artery Occlusion Following Triamcinolone Injection of the Lacrimal Gland. 61
31600385 2019
26
Seven Points That Explain the Lack of Effect from Reperfusion Therapy in Central Retinal Artery Occlusion. 61
31511166 2019
27
Visual impairment in high flow and low flow carotid cavernous fistula. 61
31492949 2019
28
SUDDEN VISION LOSS FROM CENTRAL RETINAL ARTERY OCCLUSION AS A PRESENTING SYMPTOM OF MITRAL VALVE PAPILLARY FIBROELASTOMA. 61
31574007 2019
29
Arteritic Orbital Ischemia Producing Afferent and Efferent Pupillary Defects. 61
31524841 2019
30
[Eye involvement in large vesssel vasculitis (giant cell arteritis and Takayasu's arteritis)]. 61
31463637 2019
31
Acute blindness as a presenting sign of left atrial myxoma in a pediatric patient: A case report and literature review. 61
31567993 2019
32
Competing Embolic Mechanisms in Acute Central Retinal Artery Occlusion. 61
31449481 2019
33
Risk of acute stroke in patients with retinal artery occlusion: a systematic review and meta-analysis. 61
31527762 2019
34
Central Retinal Artery Occlusion Associated with Carotid Artery Occlusion. 61
31403098 2019
35
Clinical Observations and the Anatomical Basis of Blindness After Facial Hyaluronic Acid Injection. 61
31006827 2019
36
Assessing Retrobulbar Hyaluronidase as a Treatment for Filler-Induced Blindness in a Cadaver Model. 61
31348334 2019
37
A middle hyper-reflective band on spectral domain optical coherence tomography in a case of acute nonarteritic central retinal artery occlusion with sparing of cilioretinal artery. 61
31332136 2019
38
Takayasu's arteritis: a unique ophthalmic presentation with CRAO and BRVO. 61
31420422 2019
39
The Utility of Fundus Fluorescein Angiography in Neuro-Ophthalmology. 61
31528186 2019
40
Central retinal artery occlusion after Descemet membrane reposition by intracameral air: A case report. 61
31432690 2019
41
[Spontaneous visual recovery following a central retinal artery occlusion in a patient with a cilioretinal artery]. 61
31303015 2019
42
CASE SERIES OF HYPERBARIC OXYGEN THERAPY FOR CENTRAL RETINAL ARTERY OCCLUSION. 61
31306292 2019
43
Direct carotid puncture for endovascular thrombectomy in acute ischemic stroke. 61
30954938 2019
44
Central retinal artery occlusion-A new, provisional treatment approach. 61
30707925 2019
45
Preferred practice pattern for central retinal artery occlusion management. 61
30946807 2019
46
Occlusion of the central retinal artery in Plasmodium falciparum malaria. 61
31350230 2019
47
Occurrence of Hemi-Central Retinal Artery Occlusion Following Embolization in a Case of Recurrent Juvenile Nasopharyngeal Angiofibroma. 61
31233156 2019
48
Neurofibromatosis Type 1 Vasculopathy Presenting as Impending Central Retinal Artery Occlusion. 61
30540635 2019
49
[Central retinal artery occlusion of the right eye with bifid cilioretinal artery]. 61
31104876 2019
50
Coexistent central retinal vein and artery occlusion in a patient with psoriasis receiving ustekinumab. 61
30502969 2019

Variations for Central Retinal Artery Occlusion

Expression for Central Retinal Artery Occlusion

Search GEO for disease gene expression data for Central Retinal Artery Occlusion.

Pathways for Central Retinal Artery Occlusion

GO Terms for Central Retinal Artery Occlusion

Cellular components related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cell surface GO:0009986 9.65 VEGFA THY1 PLG PLAT CD40LG
2 extracellular region GO:0005576 9.65 VEGFA THY1 SERPINC1 PRTN3 PLG PLAT
3 collagen-containing extracellular matrix GO:0062023 9.55 SERPINC1 PRTN3 PLG PLAT F2
4 extracellular space GO:0005615 9.32 VEGFA SERPINC1 PRTN3 PLG PLAT HMOX1

Biological processes related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 proteolysis GO:0006508 9.83 PRTN3 PLG PLAT LPA F2
2 hemostasis GO:0007599 9.43 SERPINC1 PLG F2
3 regulation of blood coagulation GO:0030193 9.4 SERPINC1 F2
4 negative regulation of fibrinolysis GO:0051918 9.37 PLG F2
5 negative regulation of cell-cell adhesion mediated by cadherin GO:2000048 9.32 VEGFA PLG
6 trans-synaptic signaling by BDNF, modulating synaptic transmission GO:0099183 9.16 PLG PLAT
7 fibrinolysis GO:0042730 9.13 PLG PLAT F2
8 blood coagulation GO:0007596 9.1 SERPINC1 PRTN3 PLG PLAT F2 BLOC1S6

Molecular functions related to Central Retinal Artery Occlusion according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein binding GO:0005515 10.2 VEGFA THY1 SERPINC1 RHNO1 PRTN3 PLG
2 peptidase activity GO:0008233 9.65 PRTN3 PLG PLAT LPA F2
3 heparin binding GO:0008201 9.46 VEGFA SERPINC1 LPA F2
4 apolipoprotein binding GO:0034185 9.37 PLG LPA
5 serine-type endopeptidase activity GO:0004252 9.35 PRTN3 PLG PLAT LPA F2
6 serine-type peptidase activity GO:0008236 9.02 PRTN3 PLG PLAT LPA F2

Sources for Central Retinal Artery Occlusion

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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