Central Sleep Apnea

Categories: Mental diseases, Neuronal diseases, Respiratory diseases

Aliases & Classifications for Central Sleep Apnea

MalaCards integrated aliases for Central Sleep Apnea:

Name: Central Sleep Apnea 12 15
Central Sleep Apnea Syndrome 12 29 6 71
Sleep Apnea, Central 43 71
Central Sleep Apnea, Primary 71
Primary Central Sleep Apnea 12


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Disease Ontology 12 DOID:9220
MeSH 43 D020182
NCIt 49 C116046
UMLS 71 C0520680 C0751762 C3887547

Summaries for Central Sleep Apnea

Disease Ontology : 12 A sleep apnea that is characterized by a malfunction of the basic neurological controls for breathing rate and the failure to give the signal to inhale, causing the individual to miss one or more cycles of breathing.

MalaCards based summary : Central Sleep Apnea, also known as central sleep apnea syndrome, is related to sleep apnea and mixed sleep apnea, and has symptoms including apnea An important gene associated with Central Sleep Apnea is CHAT (Choline O-Acetyltransferase), and among its related pathways/superpathways are Oxytocin signaling pathway and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The drugs Zopiclone and Opium have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and spinal cord, and related phenotypes are cardiovascular system and muscle

Related Diseases for Central Sleep Apnea

Diseases in the Sleep Apnea family:

Central Sleep Apnea

Diseases related to Central Sleep Apnea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 266)
# Related Disease Score Top Affiliating Genes
1 sleep apnea 31.2 REN PHOX2B NPPB NOS3 LEP HCRT
2 mixed sleep apnea 30.8 SRC HCRT
3 congestive heart failure 30.3 REN NPPB NPPA NOS3 CRP ACE
4 atrial standstill 1 30.1 NPPB NPPA ACE
5 fabry disease 29.9 NPPB NOS3 CRP
6 aspiration pneumonia 29.9 CRP CHAT ACE
7 heart disease 29.9 REN NPPB NPPA NOS3 LEP CRP
8 systolic heart failure 29.9 NPPB NPPA NOS3 HSPB7 CRP ACE
9 central hypoventilation syndrome, congenital 29.9 PHOX2B KCNK3 HCRT
10 coronary heart disease 1 29.9 NPPB NOS3 CRP ACE
11 diabetic neuropathy 29.8 REN LEP ACE
12 sleep disorder 29.8 REN LEP HCRT CRP ACE
13 pulmonary disease, chronic obstructive 29.8 SRC NPPB CRP ACE
14 hypertensive heart disease 29.7 REN NPPB NPPA ACE
15 atherosclerosis susceptibility 29.6 NOS3 LEP CRP ACE
16 end stage renal disease 29.5 REN NOS3 CRP ACE
17 mitral valve insufficiency 29.5 REN NPPB NPPA CRP ACE
18 left bundle branch hemiblock 29.4 REN NPPB CRP ACE
19 heart valve disease 29.4 REN NPPB NPPA CRP ACE
20 carotid stenosis 29.3 REN NOS3 CRP ACE
21 respiratory failure 29.3 REN NPPB NPPA HCRT CRP CHAT
22 atrial fibrillation 29.2 REN NPPB NPPA NOS3 CRP ACE
23 chronic kidney disease 29.2 REN NPPB NPPA NOS3 LEP CRP
24 kidney disease 29.1 REN NPPB NPPA NOS3 LEP CRP
25 pulmonary edema 29.1 REN NPPB NPPA NOS3 CRP ACE
26 dilated cardiomyopathy 29.0 REN NPPB NPPA NOS3 HSPB7 CRP
27 migraine with or without aura 1 28.7 REN NOS3 LEP HCRT CRP ACE
28 pulmonary hypertension 28.6 REN NPPB NPPA NOS3 KCNK3 CRP
29 stroke, ischemic 28.5 SRC REN NPPB NPPA NOS3 CRP
30 apnea, obstructive sleep 28.4 REN PHOX2B NPPB NOS3 LEP HCRT
31 cerebrovascular disease 28.4 REN NPPB NPPA LEP CRP ARIH1
32 myocardial infarction 28.3 SRC REN NPPB NPPA NOS3 LEP
33 idiopathic alveolar hypoventilation syndrome 12.0
34 chiari malformation 11.7
35 chiari malformation type i 11.7
36 chiari malformation type ii 11.6
37 vasculogenic impotence 10.4 NPPA ACE
38 toxic myocarditis 10.4 NPPB ACE
39 chronic mountain sickness 10.4 NPPB NOS3
40 anterolateral myocardial infarction 10.3 NPPB NPPA ACE
41 idiopathic edema 10.3 NPPB NPPA ACE
42 cardiogenic shock 10.3 NPPB CRP
43 chronic thromboembolic pulmonary hypertension 10.3 NPPB CRP
44 apnea, central sleep 10.3
45 chronic pulmonary heart disease 10.3 NPPB NOS3 ACE
46 obesity-hypoventilation syndrome 10.2
47 chronic pain 10.2
48 mediastinum teratoma 10.2 CRP ACE
49 acute dacryoadenitis 10.2 CRP ACE
50 renal artery obstruction 10.2 REN ACE

Graphical network of the top 20 diseases related to Central Sleep Apnea:

Diseases related to Central Sleep Apnea

Symptoms & Phenotypes for Central Sleep Apnea

UMLS symptoms related to Central Sleep Apnea:


MGI Mouse Phenotypes related to Central Sleep Apnea:

# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.93 ACE CABP4 CHAT CRP HCRT HSPB7
2 muscle MP:0005369 9.5 CHAT HCRT HSPB7 LEP NOS3 NPPA
3 respiratory system MP:0005388 9.23 CHAT HCRT HSPB7 KCNK3 LEP NOS3

Drugs & Therapeutics for Central Sleep Apnea

Drugs for Central Sleep Apnea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 64)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Zopiclone Approved Phase 4 43200-80-2 5735
Opium Approved, Illicit Phase 4 8008-60-4
tannic acid Approved Phase 4 1401-55-4
Trazodone Approved, Investigational Phase 4 19794-93-5 5533
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
Angiotensin II Approved, Investigational Phase 4 4474-91-3, 11128-99-7, 68521-88-0 172198
Losartan Approved Phase 4 114798-26-4 3961
Promethazine Approved, Investigational Phase 4 60-87-7 4927
Diphenhydramine Approved, Investigational Phase 4 58-73-1, 147-24-0 3100
Zolpidem Approved Phase 4 82626-48-0 5732
11 Opium Poppy Phase 4
12 Antidepressive Agents Phase 4
13 Serotonin Uptake Inhibitors Phase 4
14 Angiotensin Receptor Antagonists Phase 4
15 Angiotensin II Type 1 Receptor Blockers Phase 4
16 Angiotensinogen Phase 4
17 Antihypertensive Agents Phase 4
18 Anti-Arrhythmia Agents Phase 4
19 Giapreza Phase 4
20 Hypnotics and Sedatives Phase 4
21 GABA Agonists Phase 4
Desogestrel Approved Phase 2, Phase 3 54024-22-5 40973
Fluoxetine Approved, Vet_approved Phase 3 54910-89-3 3386
Acetazolamide Approved, Vet_approved Phase 3 59-66-5 1986
Buspirone Approved, Investigational Phase 3 36505-84-7 2477
26 Contraceptive Agents Phase 2, Phase 3
27 Progestins Phase 2, Phase 3
28 Hormones Phase 2, Phase 3
29 Contraceptives, Oral Phase 2, Phase 3
30 Hormone Antagonists Phase 2, Phase 3
31 Cytochrome P-450 Enzyme Inhibitors Phase 3
32 diuretics Phase 3
33 Anticonvulsants Phase 3
34 Carbonic Anhydrase Inhibitors Phase 3
35 Serotonin Receptor Agonists Phase 3
36 Psychotropic Drugs Phase 3
37 Anti-Anxiety Agents Phase 3
38 Neurotransmitter Agents Phase 3
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
Ethinyl Estradiol Approved 57-63-6 5991
Polyestradiol phosphate Approved 28014-46-2
Ticagrelor Approved 274693-27-5 9871419
Norepinephrine Approved 51-41-2 439260
Riociguat Approved 625115-55-1
Metronidazole Approved 443-48-1 4173
Ethanol Approved 64-17-5 702
Fluoxymesterone Approved, Illicit 76-43-7 6446
Warfarin Approved 81-81-2 6691 54678486
Spironolactone Approved 52-01-7, 1952-01-7 5833

Interventional clinical trials:

(show top 50) (show all 99)
# Name Status NCT ID Phase Drugs
1 Adaptative Servoventilation Compliance in Left Ventricular Dysfunction Patients With Central Sleep Apnea: Benefit of One Month Hypnotic (Zopiclone) Versus Placebo Unknown status NCT02820441 Phase 4 Zopiclone;Placebo
2 Effect of Acetazolamide on Central Sleep Apnea Related to Opium Consumption Unknown status NCT02371473 Phase 4 Acetazolamide-placebo;Placebo-acetazolamide
3 Cardiac Resynchronisation Therapy in Combination With Overdrive Pacing in the Treatment of Central Sleep Apnea in CHF Completed NCT00551499 Phase 4
4 Comparison of Therapeutic Oxygen Versus Medical Air for the Treatment of Central Sleep Apnea in Infants and Children With Prader Willi Syndrome: A Proof of Concept Study Recruiting NCT03031626 Phase 4
5 A Multi-Centre, Randomized Study to Assess the Effects of Adaptive Servo Ventilation (ASV) on Survival and Frequency of Hospital Admissions in Patients With Heart Failure (HF) and Sleep Apnea (SA)-The ADVENT-HF Trial Recruiting NCT01128816 Phase 4
6 Evaluation of Nocturnal Oxygen Needs in the Treatment of Central Sleep Apnea in Patients With Chronic Heart Failure. Recruiting NCT03254212 Phase 4
7 Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury Recruiting NCT02922894 Phase 4 Trazodone;Placebo
8 Oxygen Versus PAP for Treatment of Sleep Apnea in Chronic Heart Failure Active, not recruiting NCT01807897 Phase 4
9 Effect of Angiotensin Receptor Blockers on Periodic Breathing During Sleep in Hypoxia Active, not recruiting NCT03335904 Phase 4 Losartan;Placebo
10 Central Sleep Apnea: Physiologic Mechanisms to Inform Treatment Not yet recruiting NCT04118387 Phase 4 Acetazolamide + supplemental oxygen + PAP therapy;Zolpidem + PAP therapy;Buspirone + PAP therapy
11 Effect of Servo-Ventilation on CO2 Regulation and Heart Rate Variability Not yet recruiting NCT03890939 Phase 4
12 Bilevel Positive Pressure Ventilation (BIPAP)in Patients With Sleep Disorders Breathing (SDB)and Congestive Heart Failure (CHF):Comparison of Two Diagnostic Methods Unknown status NCT01501734 Phase 3
13 Efficacy of Fluoxetine Against Seizure-induced Central Apneas : a Randomized Placebo-controled Double-blind Trial. Completed NCT02569970 Phase 3 fluoxetine 20 mg;placebo 20 mg
14 Assessment of Desogestrel for a Pharmacological Recovery of Ventilatory Activity in Congenital Central Hypoventilation Syndrome - Ondine Syndrome Completed NCT01243697 Phase 2, Phase 3 desogestrel
15 The Impact of Low Flow Nocturnal Oxygen Therapy on Hospital Admissions and Mortality in Patients With Heart Failure and Central Sleep Apnea (LOFT-HF) Recruiting NCT03745898 Phase 3 Oxygen
16 Buspirone as a Potential Treatment for Recurrent Central Apneas Terminated NCT00746954 Phase 3 Acetazolamide;Buspirone
17 High-Flow-Therapy for the Treatment of Cheyne-Stokes-Respiration in Chronic Heart Failure Terminated NCT03102827 Phase 3 Oxygen
18 Dynamic Carbon Dioxide Administration for Central Sleep Apnoea in Heart Failure Unknown status NCT01041924 Phase 2
19 Safety and Efficacy Evaluation of Respicardia Therapy for Central Sleep Apnea Completed NCT01124370 Phase 2
20 Improving Sleep and Functioning in Veterans With Posttraumatic Stress Disorder Enrolling by invitation NCT04007796 Phase 2
21 Outcome and Treatment of Complex Sleep Apnea Withdrawn NCT01137214 Phase 2
22 A Study to Evaluate the Efficacy of Seattle-PAP for the Respiratory Support of Premature Infants Completed NCT02210026 Phase 1
23 Interface Selection for Adaptive Servo Ventilation: A Randomized Controlled Study Unknown status NCT02919930
24 Study of Application of Forced Breath Technique While CPAP Therapy for Apnea Classification Unknown status NCT03432910
25 Effect of Adaptive Servoventilation on Cardiac Function, Exercise Tolerance and Quality of Life in Patients With Chronic Heart Failure and Cheyne-Stokes Respiration Unknown status NCT01212705
26 PHOX2B Mutation-Confirmed Congenital Central Hypoventilation Syndrome in A Chinese Family: Presentations From Newborn to Adulthood Unknown status NCT00652964
27 Therapeutic Effect of Desogestrel on Ventilatory Control in Patients With Congenital Central Hypoventilation Syndrome Unknown status NCT01500473 Desogestrel
28 Central Apnoeas in the Course of Transient Ischemic Attack/Ischemic Stroke: Clinical, Prognostic, Pathophysiological Elements. Unknown status NCT01723189
29 Diagnosis And Treatment of Sleep Apnea in Patient With Heart Failure DASAP-HF Study Unknown status NCT02620930
30 Non-Invasive Measurement of Respiratory Effort Unknown status NCT00528749
31 Observational and Transversal Study of Patients Treated in "Real Life"Conditions With Adaptive Servo-Ventilation Completed NCT02429986
32 Bilevel Versus Servoventilation in Complex Sleep Apnea Completed NCT01609244
33 A Randomized Trial Evaluating the Safety and Effectiveness of the remedē® System in Patients With Central Sleep Apnea Completed NCT01816776
34 Pre-operative PSG Assessment of Cardiac Surgery Inpatients Completed NCT00922168
35 Comparison of Adaptive Servo Ventilation(Bipap® Auto SV Advanced) and Oxgen Therapy in Chronic Heart Failure Patients Complicated With Central Sleep Apnea Completed NCT01187823
36 A Multi-Center Study to Assess the Performance of the Saturation Pattern Detection (SPD) Software Algorithm. Completed NCT00775346
37 BiPAP (Automatic Servo Ventilation) autoSV Advanced in Central Apnea Patients Completed NCT01199042
38 Effect of Heart Valve Replacement on Cheyne-Stokes Respiration in Patients With Rheumatic Heart Disease Completed NCT01426776
39 Effectiveness of Adaptive Servoventilation (ASV) in Patients With Central Sleep Apnea Due to Chronic Opioid Use Completed NCT01462084
40 Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude. Completed NCT03368352 Early Phase 1
41 Evaluation of Software Enhancements to the Respironics BiPAP autoSV Device Completed NCT00720213
42 Comparison of the Somnarus Sleep Apnea Diagnostic Technology SomnaPatch With Polysomnography in Sleep Disordered Breathing Completed NCT02034175
43 European Registry on the Treatment of Central and Complex Sleep-Disordered Breathing With Adaptive Servo-Ventilation Completed NCT03032029
44 Crossover Comparison of Treatment With Continuous Positive Airway Pressure and Treatment With Adaptive Servo Ventilation (SOMNOventCR) in Patients With Underlying Heart Disease, Combined Obstructive Sleep Apnea and Cheyne-Stokes Respiration. Completed NCT00811668
45 Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude Completed NCT03588676
46 Different Loop Gain Phenotypes in Patients With Chronic Systolic Heart Failure and Periodic Breathing Completed NCT03532412
47 BiPAP for Cardiomyopathy With Central Sleep Apnea Completed NCT00282789
48 Treatment of Sleep-Disordered Breathing With Predominant Central Sleep Apnea by Adaptive Servo Ventilation in Patients With Heart Failure Completed NCT00733343
49 Late-onset, Insidious Course and Invasive Treatment of Congenital Central Hypoventilation Syndrome in a Case With the Phox2B Mutation Completed NCT01225679
50 Evaluation Eines Leg Fluid Shift Und Erörterung Der hämodynamischen Und Respiratorischen Auswirkungen Auf Patienten Mit Chronischer Herzinsuffizienz Und Obstruktiver Oder Zentraler Schlafapnoe Completed NCT03092388

Search NIH Clinical Center for Central Sleep Apnea

Cochrane evidence based reviews: sleep apnea, central

Genetic Tests for Central Sleep Apnea

Genetic tests related to Central Sleep Apnea:

# Genetic test Affiliating Genes
1 Central Sleep Apnea Syndrome 29

Anatomical Context for Central Sleep Apnea

MalaCards organs/tissues related to Central Sleep Apnea:

Heart, Kidney, Spinal Cord, Brain, Lung, Eye, Tongue

Publications for Central Sleep Apnea

Articles related to Central Sleep Apnea:

(show top 50) (show all 1047)
# Title Authors PMID Year
In-depth surveillance of central sleep apnea in stable heart failure patients. 61
32474404 2020
Meta-Analysis Comparing Outcomes of Therapies for Patients With Central Sleep Apnea and Heart Failure With Reduced Ejection Fraction. 61
32430162 2020
Surgical treatment for central sleep apnea due to occipitocervical compression myelopathy in a patient with Klippel-Feil syndrome: a case report. 61
32553602 2020
Update on Apneas of Heart Failure With Reduced Ejection Fraction: Emphasis on the Physiology of Treatment: Part 2: Central Sleep Apnea. 61
31958442 2020
Prevalence of sleep-disordered breathing in opioid users with chronic pain: a systematic review and meta-analysis. 61
32105208 2020
Meta-analysis of Usefulness of Phrenic Nerve Stimulation in Central Sleep Apnea. 61
32295701 2020
Evaluation of the Impact of Body Position on Primary Central Sleep Apnea Syndrome. 61
32527712 2020
Health Supervision for People With Achondroplasia. 61
32457214 2020
Practice patterns of board-certified sleep medicine providers: a national analysis among older adult Medicare beneficiaries. 61
32024587 2020
Pacing therapies for sleep apnea and cardiovascular outcomes: A systematic review. 61
32445012 2020
Novel phrenic nerve stimulator treats Cheyne-Stokes respiration: polysomnographic insights. 61
32024583 2020
Association between central sleep apnea and atrial fibrillation/flutter in Japanese-American men: The Kuakini Honolulu Heart Program (HHP) and Honolulu-Asia Aging Study (HAAS). 61
32464488 2020
Distinguishing Obstructive Versus Central Apneas in Infrared Video of Sleep Using Deep Learning: Validation Study. 61
32441656 2020
Effect of treatment of central sleep apnea/Cheyne-Stokes respiration on left ventricular ejection fraction in heart failure: a network meta-analysis is not the answer. 61
32022672 2020
Randomized controlled trials on the comparative effect of treatment modalities of central sleep apnea with Cheyne-Stokes Respiration on cardiovascular outcomes and physiology studies required. 61
32022677 2020
Polysomnography findings in pediatric spinal muscular atrophy types 1-3. 61
32035302 2020
Insights into the effects of sleep disordered breathing on the brain in infants and children: Imaging and cerebral oxygenation measurements. 61
31883491 2020
Effect of acetazolamide on susceptibility to central sleep apnea in chronic spinal cord injury. 61
32078469 2020
Frequency and outcomes of primary central sleep apnea in a population-based study. 61
32044555 2020
Tatton-Brown-Rahman syndrome: Six individuals with novel features. 61
31961069 2020
Detecting central sleep apnea in adult patients using WatchPAT-a multicenter validation study. 61
31402439 2020
Sleep Apnea and Chronic Kidney Disease: A State-of-the-Art Review. 61
31542452 2020
Central sleep apnea alters neuronal excitability and increases the randomness in sleep-wake transitions. 61
32149619 2020
Association of serious adverse events with Cheyne-Stokes respiration characteristics in patients with systolic heart failure and central sleep apnoea: A SERVE-Heart Failure substudy analysis. 61
31218793 2020
Apneas of Heart Failure and Phenotype-Guided Treatments: Part One: OSA. 61
31047953 2020
The use and effectiveness of adaptive servo ventilation in central sleep apnea: a study of consecutive sleep clinic patients. 61
32087043 2020
Sleep for Stroke Management and Recovery Trial (Sleep SMART): Rationale and methods. 61
32019428 2020
A case of treatment-emergent central sleep apnea? 61
31992427 2020
Sleep endoscopy-directed management of Arnold-Chiari malformation: a child with persistent obstructive sleep apnea. 61
31992420 2020
Sleep Breathing Disorders in Heart Failure. 61
31735314 2020
Sleep-Induced Glottis Closure in Multiple System Atrophy Evaluated by Four-Dimensional Computed Tomography. 61
32363195 2020
Unattended sleep study in screening for sleep apnea in the acute phase of ischemic stroke. 61
31751906 2020
Effect of Ultrafiltration on Sleep Apnea and Cardiac Function in End-Stage Renal Disease. 61
31935723 2020
Adaptive Servo-Ventilation: A Comprehensive Descriptive Study in the Geneva Lake Area. 61
32309284 2020
Angiotensin II-Type I Receptor Antagonism Does Not Influence the Chemoreceptor Reflex or Hypoxia-Induced Central Sleep Apnea in Men. 61
32410951 2020
First report of concomitant subcutaneous defibrillator and phrenic nerve stimulator implantation in a patient with severe central sleep apnea and left ventricular systolic dysfunction. 61
31956502 2020
Continuous Positive Airway Pressure and Adaptive Servoventilation in Heart Failure Patients With Central Sleep Apnea With Cheyne Stokes Respiration: Are They Useful in Ameliorating Cardiac Systolic Dysfunction? 61
31855155 2019
Effect of Treatment of Central Sleep Apnea/Cheyne-Stokes Respiration on Left Ventricular Ejection Fraction in Heart Failure: A Network Meta-Analysis. 61
31855167 2019
Phrenic Nerve Stimulation for the Treatment of Central Sleep Apnea: A Pooled Cohort Analysis. 61
31855160 2019
Features of Marfan syndrome not listed in the Ghent nosology - the dark side of the disease. 61
31829751 2019
Central sleep apnea in children with obstructive sleep apnea syndrome and improvement following adenotonsillectomy. 61
31373175 2019
A contemporary review of obstructive sleep apnea. 61
31589188 2019
Association of Valproic Acid With Central Sleep Apnea Syndrome: Two Case Reports. 61
31725092 2019
Phrenic Nerve Stimulation for the Treatment of Central Sleep Apnea: A Pooled Cohort Analysis. 61
31685094 2019
Emergence of Central Sleep Apnea Events After Maxillomandibular Advancement Surgery for Obstructive Sleep Apnea. 61
31302064 2019
Chronic Opioid Therapy and Sleep: An American Academy of Sleep Medicine Position Statement. 61
31739858 2019
What is the remaining status of adaptive servo-ventilation? The results of a real-life multicenter study (OTRLASV-study) : Adaptive servo-ventilation in real-life conditions. 61
31665026 2019
Effect of Treatment of Central Sleep Apnea/Cheyne-Stokes Respiration on Left Ventricular Ejection Fraction in Heart Failure: A Network Meta-Analysis. 61
31662181 2019
The Effect of Positive Airway Pressure Treatment of Obstructive and Central Sleep Apnea on the Recurrence of Atrial Fibrillation/Flutter Postintervention. 61
31596211 2019
Association of Valproic Acid With Central Sleep Apnea Syndrome: Two Case Reports. 61
31609807 2019

Variations for Central Sleep Apnea

ClinVar genetic disease variations for Central Sleep Apnea:

6 ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 CHAT NM_020549.4(CHAT):c.2081C>G (p.Ser694Cys)SNV Pathogenic 523529 rs201439531 10:50872926-50872926 10:49664880-49664880
2 CHAT NM_020549.4(CHAT):c.1061C>T (p.Thr354Met)SNV Conflicting interpretations of pathogenicity 523528 rs769234940 10:50835781-50835781 10:49627735-49627735

Expression for Central Sleep Apnea

Search GEO for disease gene expression data for Central Sleep Apnea.

Pathways for Central Sleep Apnea

Pathways related to Central Sleep Apnea according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
Show member pathways
Show member pathways
11.03 REN NOS3 ACE
3 10.64 REN NPPA ACE

GO Terms for Central Sleep Apnea

Cellular components related to Central Sleep Apnea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.77 SRC REN NPPB NPPA NOS3 LEP
2 extracellular region GO:0005576 9.28 REN PSG2 NPPB NPPA LEP HCRT

Biological processes related to Central Sleep Apnea according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 neuropeptide signaling pathway GO:0007218 9.71 NPPB NPPA HCRT
2 positive regulation of cold-induced thermogenesis GO:0120162 9.67 PHOX2B LEP HCRT
3 female pregnancy GO:0007565 9.65 PSG2 NPPA LEP
4 amyloid-beta metabolic process GO:0050435 9.52 REN ACE
5 negative regulation of systemic arterial blood pressure GO:0003085 9.51 NPPB NPPA
6 regulation of vascular permeability GO:0043114 9.46 SRC NPPB
7 angiotensin maturation GO:0002003 9.43 REN ACE
8 cGMP biosynthetic process GO:0006182 9.4 NPPB NPPA
9 negative regulation of potassium ion transport GO:0043267 9.37 NOS3 HCRT
10 negative regulation of lipid storage GO:0010888 9.32 LEP CRP
11 receptor guanylyl cyclase signaling pathway GO:0007168 9.26 NPPB NPPA
12 ovulation from ovarian follicle GO:0001542 9.16 NOS3 LEP
13 regulation of blood vessel diameter GO:0097746 9.13 NPPB NOS3 ACE
14 regulation of blood pressure GO:0008217 9.1 REN NPPB NPPA NOS3 LEP ACE

Molecular functions related to Central Sleep Apnea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 hormone activity GO:0005179 9.33 NPPB NPPA LEP
2 signaling receptor binding GO:0005102 9.02 SRC REN NPPB NPPA LEP
3 hormone receptor binding GO:0051427 8.96 NPPB NPPA

Sources for Central Sleep Apnea

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
31 HPO
32 ICD10
33 ICD10 via Orphanet
37 LifeMap
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
54 Novoseek
57 OMIM via Orphanet
61 PubMed
70 Tocris
72 UMLS via Orphanet
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