Central Sleep Apnea disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

MCID: CNT015 MIFTS: 41	Central Sleep Apnea Categories: Mental diseases, Neuronal diseases, Respiratory diseases	Data Licensing For inquiries, contact: [email protected]
Genes Tissues Related diseases Publications Symptoms & Phenotypes Drugs Expand all tables

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Aliases & Classifications for Central Sleep Apnea

MalaCards integrated aliases for Central Sleep Apnea:

Name: Central Sleep Apnea ¹¹ ¹⁴ ⁷⁵

Central Sleep Apnea Syndrome ¹¹ ⁷¹

Sleep Apnea, Central ⁴³ ⁷¹

Central Sleep Apnoea Due to Substances Including Medications ³³

Csas - [central Sleep Apnoea Syndrome] ³³

Central Sleep Apnoea Syndrome ³³

Central Sleep Apnea, Primary ⁷¹

Csa - [central Sleep Apnoea] ³³

Primary Central Sleep Apnea ¹¹

Classifications:

MalaCards categories:
Anatomical: Mental diseases Respiratory diseases Neuronal diseases

See all MalaCards categories (disease lists)

ICD11: ³³

Sleep-wake disorders

Sleep-related breathing disorders

Central sleep apnoeas

Central sleep apnoea due to a medical condition with Cheyne-Stokes breathing

Central sleep apnoea due to a medical condition without Cheyne-Stokes breathing

Central sleep apnoea due to a medication or substance

Central sleep apnoea due to high-altitude periodic breathing

Central sleep apnoeas, unspecified

Other specified central sleep apnoeas

Primary central sleep apnoea

External Ids:

Disease Ontology ¹¹ DOID:9220

MeSH ⁴³ D020182

NCIt ⁴⁹ C116046

ICD11 ³³ 1193320862 1193320862/other 1193320862/unspecified more

UMLS ⁷¹ C0520680 C0751762 C3887547

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Summaries for Central Sleep Apnea

Disease Ontology: ¹¹ A sleep apnea that is characterized by a malfunction of the basic neurological controls for breathing rate and the failure to give the signal to inhale, causing the individual to miss one or more cycles of breathing.

MalaCards based summary: Central Sleep Apnea, also known as central sleep apnea syndrome, is related to sleep apnea and apnea, obstructive sleep, and has symptoms including apnea An important gene associated with Central Sleep Apnea is PHOX2B (Paired Like Homeobox 2B). The drugs Opium and Zolpidem have been mentioned in the context of this disorder. Affiliated tissues include heart, spinal cord and medulla oblongata, and related phenotypes are nervous system and cardiovascular system

Wikipedia: ⁷⁵ Central sleep apnea (CSA) or central sleep apnea syndrome (CSAS) is a sleep-related disorder in which... more...

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Related Diseases for Central Sleep Apnea

Diseases in the Sleep Apnea family:

Central Sleep Apnea

Diseases related to Central Sleep Apnea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 340)

#	Related Disease	Score	Top Affiliating Genes
1	sleep apnea	31.6	REN PHOX2B NPPB LEP KCNK3 HCRT
2	apnea, obstructive sleep	31.0	REN NPPB LEP IGLON5 HCRT CRP
3	systolic heart failure	30.9	REN NPPB CRP ACE
4	respiratory failure	30.8	REN NPPB CRP ACE
5	atrioventricular block	30.5	NPPB CRP ACE
6	mitral valve insufficiency	30.5	REN NPPB CRP ACE
7	heart valve disease	30.5	REN NPPB CRP ACE
8	pulmonary hypertension	30.4	REN NPPB KCNK3 CRP ACE
9	stroke, ischemic	30.4	REN NPPB CRP ACE
10	sleep disorder	30.4	REN LEP IGLON5 HCRT CRP ACE
11	pulmonary edema	30.3	REN NPPB CRP ACE
12	chronic kidney disease	30.3	REN NPPB LEP CRP ACE
13	diabetes mellitus, ketosis-prone	30.3	REN CRP ACE
14	carotid stenosis	30.2	REN CRP ACE
15	pulmonary embolism	30.2	NPPB CRP ACE
16	cardiac arrest	30.2	NPPB CRP ACE
17	polycythemia	30.1	REN CRP ACE
18	left bundle branch hemiblock	30.1	REN NPPB CRP ACE
19	hypertensive heart disease	30.1	REN NPPB CRP ACE
20	intermediate coronary syndrome	30.1	REN NPPB CRP ACE
21	third-degree atrioventricular block	30.1	REN NPPB CRP ACE
22	transient cerebral ischemia	30.1	REN NPPB CRP ACE
23	covid-19	30.1	REN NPPB CRP ACE
24	aortic valve disease 2	30.1	REN NPPB CRP ACE
25	acute myocardial infarction	30.1	REN NPPB CRP ACE
26	congenital central hypoventilation syndrome	30.1	PHOX2B LBX1 KCNK9 KCNK3 HCRT GPR4
27	adult syndrome	30.0	REN LEP CRP
28	hypothyroidism	29.9	REN NPPB LEP CRP ACE
29	anxiety	29.6	PALS1 LEP HCRT CRP ACE
30	migraine with or without aura 1	29.4	REN LEP KCNK9 KCNK3 HCRT CRP
31	nervous system disease	29.1	REN PHOX2B NALCN LEP HCRT CRP
32	idiopathic alveolar hypoventilation syndrome	11.5
33	chiari malformation	11.2
34	chiari malformation type i	11.2
35	chiari malformation type ii	11.2
36	potocki-lupski syndrome	11.2
37	heart disease	10.9
38	congestive heart failure	10.8
39	atrial fibrillation	10.5
40	mixed sleep apnea	10.5
41	anterolateral myocardial infarction	10.4	NPPB ACE
42	hypoaldosteronism	10.3	REN ACE
43	renal artery obstruction	10.3	REN ACE
44	pyeloureteritis cystica	10.3	REN CRP
45	polycystic kidney disease 4	10.3	REN NPPB
46	toxic myocarditis	10.3	NPPB ACE
47	orthostatic proteinuria	10.3	REN ACE
48	inferior myocardial infarction	10.3	NPPB ACE
49	hypertension, diastolic	10.3	REN ACE
50	apnea, central sleep	10.3

Graphical network of the top 20 diseases related to Central Sleep Apnea:

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Symptoms & Phenotypes for Central Sleep Apnea

UMLS symptoms related to Central Sleep Apnea:

apnea

MGI Mouse Phenotypes related to Central Sleep Apnea:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	nervous system	MP:0003631	9.9	GPR4 HCRT KCNK3 KCNK9 LBX1 LEP
2	cardiovascular system	MP:0005385	9.7	ACE CRP GPR4 HCRT KCNK3 KCNK9
3	respiratory system	MP:0005388	9.17	GPR4 HCRT KCNK3 KCNK9 LEP NALCN

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Drugs & Therapeutics for Central Sleep Apnea

Drugs for Central Sleep Apnea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

Opium

Approved, Illicit

Phase 4

8008-60-4

Zolpidem

Approved

Phase 4

82626-48-0

5732

Diphenhydramine

Approved, Investigational

Phase 4

147-24-0, 58-73-1

3100

Promethazine

Approved, Investigational

Phase 4

60-87-7

4927

Ethanol

Approved

Phase 4

64-17-5

702

Naltrexone

Approved, Investigational, Vet_approved

Phase 4

16590-41-3

5360515

Zopiclone

Approved

Phase 4

43200-80-2

5735

Opium Poppy

Phase 4

GABA Agonists

Phase 4

Narcotics

Phase 4

Narcotic Antagonists

Phase 4

Hypnotics and Sedatives

Phase 4

Fluoxetine

Approved, Vet_approved

Phase 3

54910-89-3

3386

Desogestrel

Approved

Phase 2, Phase 3

54024-22-5

40973

Buspirone

Approved, Investigational

Phase 3

36505-84-7

2477

Acetazolamide

Approved, Vet_approved

Phase 3

59-66-5, 1424-27-7

1986

Antidepressive Agents

Phase 3

Serotonin Uptake Inhibitors

Phase 3

Cytochrome P-450 Enzyme Inhibitors

Phase 3

Hormones

Phase 2, Phase 3

Hormone Antagonists

Phase 2, Phase 3

Contraceptives, Oral, Hormonal

Phase 2, Phase 3

Contraceptives, Oral

Phase 2, Phase 3

Contraceptive Agents

Phase 2, Phase 3

Progestins

Phase 2, Phase 3

Carbonic Anhydrase Inhibitors

Phase 3

Neurotransmitter Agents

Phase 3

Anti-Anxiety Agents

Phase 3

Psychotropic Drugs

Phase 3

Anticonvulsants

Phase 3

Serotonin Receptor Agonists

Phase 3

diuretics

Phase 3

Serotonin

Investigational, Nutraceutical

Phase 3

50-67-9

5202

Ticagrelor

Approved

274693-27-5

9871419

Estradiol

Approved, Investigational, Vet_approved

50-28-2

5757

Ethinylestradiol

Approved

57-63-6

5991

Polyestradiol phosphate

Approved

28014-46-2

Metronidazole

Approved

443-48-1, 69198-10-3

4173

Norepinephrine

Approved

51-41-2

439260

Estradiol 3-benzoate

Estradiol 17 beta-cypionate

Contraceptives, Oral, Combined

Analgesics, Opioid

Interventional clinical trials:

(show top 50) (show all 74)

#	Name	Status	NCT ID	Phase	Drugs
1	Effect of Acetazolamide on Central Sleep Apnea Related to Opium Consumption	Unknown status	NCT02371473	Phase 4	Acetazolamide-placebo;Placebo-acetazolamide
2	Cardiac Resynchronisation Therapy in Combination With Overdrive Pacing in the Treatment of Central Sleep Apnea in CHF	Completed	NCT00551499	Phase 4
3	Central Sleep Apnea: Physiologic Mechanisms to Inform Treatment	Recruiting	NCT04118387	Phase 4	Acetazolamide + supplemental oxygen + PAP therapy;Zolpidem + PAP therapy;Buspirone + PAP therapy
4	Comparison of Therapeutic Oxygen Versus Medical Air for the Treatment of Central Sleep Apnea in Infants and Children With Prader Willi Syndrome: A Proof of Concept Study	Recruiting	NCT03031626	Phase 4
5	Evaluation of Nocturnal Oxygen Needs in the Treatment of Central Sleep Apnea in Patients With Chronic Heart Failure.	Recruiting	NCT03254212	Phase 4
6	Effects of Naltrexone on Nocturnal Breathing Patterns at Altitude	Recruiting	NCT05037032	Phase 4	Naltrexone Pill;Placebo
7	Adaptative Servoventilation Compliance in Left Ventricular Dysfunction Patients With Central Sleep Apnea: Benefit of One Month Hypnotic (Zopiclone) Versus Placebo	Terminated	NCT02820441	Phase 4	Zopiclone;Placebo
8	Efficacy of Fluoxetine Against Seizure-induced Central Apneas : a Randomized Placebo-controled Double-blind Trial.	Completed	NCT02569970	Phase 3	fluoxetine 20 mg;placebo 20 mg
9	Assessment of Desogestrel for a Pharmacological Recovery of Ventilatory Activity in Congenital Central Hypoventilation Syndrome - Ondine Syndrome	Completed	NCT01243697	Phase 2, Phase 3	desogestrel
10	The Impact of Low Flow Nocturnal Oxygen Therapy on Hospital Admissions and Mortality in Patients With Heart Failure and Central Sleep Apnea (LOFT-HF)	Terminated	NCT03745898	Phase 3	Oxygen
11	Buspirone as a Potential Treatment for Recurrent Central Apneas	Terminated	NCT00746954	Phase 3	Acetazolamide;Buspirone
12	Dynamic Carbon Dioxide Administration for Central Sleep Apnoea in Heart Failure	Unknown status	NCT01041924	Phase 2
13	Safety and Efficacy Evaluation of Respicardia Therapy for Central Sleep Apnea	Completed	NCT01124370	Phase 2
14	A Study to Evaluate the Efficacy of Seattle-PAP for the Respiratory Support of Premature Infants	Completed	NCT02210026	Phase 1
15	Observational Multicenter Cohort Study of French Patients With a Central or Combined Syndrome of Sleep Apnea With a Predominant Central SAS Treated by Adaptive Servo-Ventilation	Unknown status	NCT02835638
16	Effect of Adaptive Servoventilation on Cardiac Function, Exercise Tolerance and Quality of Life in Patients With Chronic Heart Failure and Cheyne-Stokes Respiration	Unknown status	NCT01212705
17	Study of Application of Forced Breath Technique While CPAP Therapy for Apnea Classification	Unknown status	NCT03432910
18	PHOX2B Mutation-Confirmed Congenital Central Hypoventilation Syndrome in A Chinese Family: Presentations From Newborn to Adulthood	Unknown status	NCT00652964
19	Central Apnea in Patients Receiving Ticagrelor	Unknown status	NCT03540459
20	Therapeutic Effect of Desogestrel on Ventilatory Control in Patients With Congenital Central Hypoventilation Syndrome	Unknown status	NCT01500473		Desogestrel
21	Central Apnoeas in the Course of Transient Ischemic Attack/Ischemic Stroke: Clinical, Prognostic, Pathophysiological Elements.	Unknown status	NCT01723189
22	Observational and Transversal Study of Patients Treated in "Real Life"Conditions With Adaptive Servo-Ventilation	Completed	NCT02429986
23	Treatment of Sleep-Disordered Breathing With Predominant Central Sleep Apnea by Adaptive Servo Ventilation in Patients With Heart Failure	Completed	NCT00733343
24	Central Sleep Apnea and New-onset Cardiac Resynchronization in Patients With Conventional Pacemaker or ICD Therapy: a Multicenter, Randomized Clinical Trial	Completed	NCT01970423
25	Central Sleep Apnea Treated by CO2 Supplied by a Novel Device	Completed	NCT04907058
26	BiPAP for Cardiomyopathy With Central Sleep Apnea	Completed	NCT00282789
27	A Randomized Trial Evaluating the Safety and Effectiveness of the remedē® System in Patients With Central Sleep Apnea	Completed	NCT01816776
28	Comparison of Adaptive Servo Ventilation(Bipap® Auto SV Advanced) and Oxgen Therapy in Chronic Heart Failure Patients Complicated With Central Sleep Apnea	Completed	NCT01187823
29	Effectiveness of Adaptive Servoventilation (ASV) in Patients With Central Sleep Apnea Due to Chronic Opioid Use	Completed	NCT01462084
30	Prospective Multicentre Observational French Cohort Study of Patients With Heart Failure and Central Sleep Apnoea Requiring Adaptive Servo-Ventilation (PaceWave, AutoSet CS) Treatment	Completed	NCT01831128
31	Comparison of the Somnarus Sleep Apnea Diagnostic Technology SomnaPatch With Polysomnography in Sleep Disordered Breathing	Completed	NCT02034175
32	Registry on the Treatment of Central and Complex Sleep-Disordered Breathing With Adaptive Servo-Ventilation	Completed	NCT03032029
33	A Multi-Center Study to Assess the Performance of the Saturation Pattern Detection (SPD) Software Algorithm.	Completed	NCT00775346
34	Pre-operative PSG Assessment of Cardiac Surgery Inpatients	Completed	NCT00922168
35	Post Approval Study of the remedē System	Completed	NCT03425188
36	Heart Function in Patients Assessed for Sleep Disordered Breathing (SDB)	Completed	NCT03226652
37	Bilevel Versus Servoventilation in Complex Sleep Apnea	Completed	NCT01609244
38	Effect of Heart Valve Replacement on Cheyne-Stokes Respiration in Patients With Rheumatic Heart Disease	Completed	NCT01426776
39	Crossover Comparison of Treatment With Continuous Positive Airway Pressure and Treatment With Adaptive Servo Ventilation (SOMNOventCR) in Patients With Underlying Heart Disease, Combined Obstructive Sleep Apnea and Cheyne-Stokes Respiration.	Completed	NCT00811668
40	Evaluation of Software Enhancements to the Respironics BiPAP autoSV Device	Completed	NCT00720213
41	Diagnostic Validation of the DreamKit Device Against Polysomnography	Completed	NCT04671342
42	Evaluation of ApneaLink Plus Scoring Capabilities	Completed	NCT00823134
43	Evaluation of the Philips Respironics BiPAP autoSV Devices in Subjects With Sleep Disorders.	Completed	NCT01626989
44	Feasibility of a Variable Carbon Dioxide (CO2) Rebreathe Device ("Smart CO2") to Treat Obstructive Sleep Apnea	Completed	NCT03552133
45	Validation of the DreamKit Plethysmography-derived Respiratory Effort Signal Against Esophageal Pressure	Completed	NCT04926077
46	BiPAP (Automatic Servo Ventilation) autoSV Advanced in Central Apnea Patients	Completed	NCT01199042
47	Validation of Breathing Event Detection of the Philips Respironics Sleep Therapy System REMstar Auto A-Flex Compared to Clinical Polysomnography	Completed	NCT01175031
48	Evaluation Eines Leg Fluid Shift Und Erörterung Der hämodynamischen Und Respiratorischen Auswirkungen Auf Patienten Mit Chronischer Herzinsuffizienz Und Obstruktiver Oder Zentraler Schlafapnoe	Completed	NCT03092388
49	Impact of Arterial Oxygen Saturation Range on Ventilatory Stability in Extremely Premature Infants	Completed	NCT03695900
50	Cognitive Consequences of an Activation of the Cortical Drive to Breath	Completed	NCT03095729

Search NIH Clinical Center for Central Sleep Apnea

Cochrane evidence based reviews: sleep apnea, central

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Genetic Tests for Central Sleep Apnea

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Anatomical Context for Central Sleep Apnea

Organs/tissues related to Central Sleep Apnea:

MalaCards : Heart, Spinal Cord, Medulla Oblongata, Kidney, Brain, Lung, Tongue

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Publications for Central Sleep Apnea

Articles related to Central Sleep Apnea:

(show top 50) (show all 1271)

#	Title	Authors	PMID	Year
1	Prevalence of obstructive sleep apnea as assessed by polysomnography in psychiatric patients with sleep-related problems. ⁶²	Okada I...Ozaki N	35029795	2022
2	Evaluation and Treatment of Central Sleep Apnea in Patients with Heart Failure. ⁶²	Fudim M...Mentz RJ	35995244	2022
3	Impact of sleep-disordered breathing on the management of children with Chiari malformation type I. ⁶²	Vagianou F...Fauroux B	35962649	2022
4	Social impairment and snoring: a unique presentation of pediatric Chiari I malformation. ⁶²	Kanney ML...Hsu DP	35946419	2022
5	Central sleep apnea in otherwise healthy term infants. ⁶²	Hayashi A...Kapur N	35962944	2022
6	Design of the remedē System Therapy (rēST) study: A prospective non-randomized post-market study collecting clinical data on safety and effectiveness of the remedē system for the treatment of central sleep apnea. ⁶²	Goldberg LR...remede System Therapy Study Group	36116293	2022
7	Effect of adaptive servo ventilation on central sleep apnea and sleep structure in systolic heart failure patients: polysomnography data from the SERVE-HF major sub study. ⁶²	Tamisier R...Woehrle H	35840352	2022
8	Sleep architecture and sleep-disordered breathing in fatal insomnia. ⁶²	Perez-Carbonell L...Santamaria J	36182725	2022
9	Correction to: 0849 Baclofen-induced severe central sleep apnea. ⁶²		36370125	2022
10	Sleep and Breathing Disturbances in Children With Leigh Syndrome: A Comparative Study. ⁶²	Ju Wang JD...Ramirez JM	36137349	2022
11	Mortality Patterns Associated with Central Sleep Apnea Among Veterans: A Large, Retrospective, Longitudinal Report. ⁶²	Agrawal R...Razjouyan J	36375082	2022
12	Disturbed Sleep is Not Good for the Heart: A Narrative Review. ⁶²	Patel M...Jain R	36453501	2022
13	Impact of Unintentional Air Leaks on Automatic Positive Airway Pressure Device Performance in Simulated Sleep Apnea Events. ⁶²	Fasquel L...Contal O	36347566	2022
14	Practice recommendations for the role of physiotherapy in the management of sleep disorders: the 2022 Brazilian Sleep Association Guidelines. ⁶²	Frange C...Drager LF	36419815	2022
15	Sleep Disorders and Coronary Artery Disease. ⁶²	Dey S...Aronow WS	36301202	2022
16	Central sleep apnea and daytime sleepiness in Niemann-Pick type C disease: a report of two cases. ⁶²	Zhang Y...Zhan S	36199263	2022
17	Transvenous Phrenic Nerve Stimulation for Central Sleep Apnea. ⁶²	Sagalow ES...Fast Z	35918232	2022
18	Severe central sleep apnea in a child with biallelic variants in NALCN. ⁶²	Maselli K...Arens R	35808948	2022
19	[Is ASV therapy a positive airway pressure or ventilation therapy? A comparison of acid-base balance per day and under ASV]. ⁶²	Barleben A...Gruning W	36104016	2022
20	Developing antisense oligonucleotides for a TECPR2 mutation-induced, ultra-rare neurological disorder using patient-derived cellular models. ⁶²	Williams LA...Dempsey GT	35860385	2022
21	Central sleep apnea treatment in patients with heart failure with reduced ejection fraction: a network meta-analysis. ⁶²	Iftikhar IH...Khayat RN	34698980	2022
22	Prevalence, clinical characteristics, and predictors of sleep disordered breathing in hospitalized heart failure patients. ⁶²	Huang B...Zhang J	36177653	2022
23	Association of OSA with cardiovascular events in women and men with acute coronary syndrome. ⁶²	Wang X...Nie S	36104289	2022
24	SARS-CoV-2 Causing Transient Central Sleep Apnea in Patients Treated for Obstructive Sleep Apnea with Continuous Positive Airway Pressure. ⁶²	Ghatak R...Saini V	36171691	2022
25	Cheyne-stokes respiration in children with heart failure. ⁶²	Singh J...Fitzgerald DA	35459626	2022
26	Innovations in Cardiac Implantable Electronic Devices. ⁶²	Khan K...Chelu MG	33651211	2022
27	Sleep-Disordered Breathing in Adults with Precapillary Pulmonary Hypertension: Prevalence and Predictors of Nocturnal Hypoxemia. ⁶²	Murta MS...Mello FCQ	35717489	2022
28	Impact of Sleep-Disordered Breathing Treatment on Ventricular Tachycardia in Patients with Heart Failure. ⁶²	Gercek M...Fox H	35956183	2022
29	Sleep-related breathing disorders in idiopathic pulmonary fibrosis are frequent and may be associated with pulmonary vascular involvement. ⁶²	Hagmeyer L...Randerath W	35922615	2022
30	Phrenic nerve stimulation for the treatment of central sleep apnea in patients with heart failure. ⁶²	Wang Y...Schobel C	35978055	2022
31	Case of buprenorphine-associated central sleep apnea resolving with dose reduction. ⁶²	Tchikrizov V...Bhardwaj SB	36052936	2022
32	The Pathogenesis of Central and Complex Sleep Apnea. ⁶²	Roberts EG...Malhotra A	35588042	2022
33	Sleep-disordered breathing in pediatric neurofibromatosis type 1. ⁶²	Bulian A...Fauroux B	35278041	2022
34	PAP therapy and readmission rates after in-hospital laboratory titration polysomnography in patients with hypoventilation. ⁶²	Johnson KG...Visintainer P	35332871	2022
35	Sleep-disordered breathing in heart failure patients with different etiologies. ⁶²	Wang T...Tong JY	35535628	2022
36	A Word of Caution: Adenotonsillectomy May Help Reduce Central Apneas, but It Is Not a Treatment for Central Sleep Apnea. ⁶²	Smith DF...Dye TJ	35642622	2022
37	Correction to: Improving Nocturnal Hypoxemic Burden with Transvenous Phrenic Nerve Stimulation for the Treatment of Central Sleep Apnea. ⁶²	Oldenburg O...Fox H	34761354	2022
38	Altitude-Induced Sleep Apnea Is Highly Dependent on Ethnic Background (Sherpa Vs. Tamang). ⁶²	Heiniger G...Heinzer R	35708530	2022
39	Central Sleep Apnea: Pathophysiologic Classification. ⁶²	Javaheri S...Badr MS	35551411	2022
40	The impact of sleep disordered breathing on cardiac troponin in acutely decompensated heart failure. ⁶²	Light MP...Owens RL	35641808	2022
41	Elevated serum matrix metalloproteinase-2 levels in heart failure patients with reduced ejection fraction and Cheyne-Stokes respiration. ⁶²	Chuang LP...Chen NH	35023473	2022
42	Transvenous Phrenic Nerve Stimulation for Central Sleep Apnea: Clinical and Billing Review. ⁶²	Teckchandani PH...Khayat RN	34808108	2022
43	Patient Related Outcome and Therapy Effects in Stimulation Treatment of Sleep-Related Breathing Disorders. ⁶²	Steffen A	35605615	2022
44	Abnormalities of the Vertebrobasilar Arterial System Leading to Sleep Disorders. ⁶²	Sabet C...Aggarwal A	35190307	2022
45	Sleep Breathing Disorders in Heart Failure. ⁶²	Coniglio AC...Mentz RJ	35465892	2022
46	Obstructive sleep apnea and nocturnal attacks of paroxysmal atrial fibrillation. ⁶²	Lin CH...Lyons OD	34931608	2022
47	Sleep-disordered breathing in school-aged children with Prader-Willi syndrome. ⁶²	Schaefer J...Nixon GM	34870583	2022
48	Average volume-assured pressure support for patients with obstructive sleep apnea with failed CPAP titration. ⁶²	Watanabe N...Diaz-Abad M	35371406	2022
49	Prevalence and clinical characteristics of sleep-disordered breathing in patients with heart failure of different left ventricular ejection fractions. ⁶²	Wang T...Tong JY	35394577	2022
50	Diagnostic and therapeutic approach of central sleep apnea in heart failure - the role of adaptive servo-ventilation. A statement of the Portuguese society of pulmonology and the Portuguese sleep association. ⁶²	Correia S...Moita J	35501278	2022

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Genes for Central Sleep Apnea

Genes related to Central Sleep Apnea (0 elite genes):

(show all 19)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	PHOX2B	Paired Like Homeobox 2B	Protein Coding	6.77	DISEASES inferred ¹⁴
2	HCRT	Hypocretin Neuropeptide Precursor	Protein Coding	6.54	DISEASES inferred ¹⁴
3	NPPB	Natriuretic Peptide B	Protein Coding	5.71	DISEASES inferred ¹⁴
4	REN	Renin	Protein Coding	5.51	DISEASES inferred ¹⁴
5	ACE	Angiotensin I Converting Enzyme	Protein Coding	5.5	DISEASES inferred ¹⁴
6	KCNK9	Potassium Two Pore Domain Channel Subfamily K Member 9	Protein Coding	5.47	DISEASES inferred ¹⁴
7	KCNK3	Potassium Two Pore Domain Channel Subfamily K Member 3	Protein Coding	5.44	DISEASES inferred ¹⁴
8	CRP	C-Reactive Protein	Protein Coding	5.36	DISEASES inferred ¹⁴
9	IGLON5	IgLON Family Member 5	Protein Coding	5.23	DISEASES inferred ¹⁴
10	PSG2	Pregnancy Specific Beta-1-Glycoprotein 2	Protein Coding	5.2	DISEASES inferred ¹⁴
11	P4HTM	Prolyl 4-Hydroxylase, Transmembrane	Protein Coding	5.16	DISEASES inferred ¹⁴
12	GPR4	G Protein-Coupled Receptor 4	Protein Coding	5.07	DISEASES inferred ¹⁴
13	TECPR2	Tectonin Beta-Propeller Repeat Containing 2	Protein Coding	5.05	DISEASES inferred ¹⁴
14	PALS1	Protein Associated With LIN7 1, MAGUK P55 Family Member	Protein Coding	5.02	DISEASES inferred ¹⁴
15	LBX1	Ladybird Homeobox 1	Protein Coding	5	DISEASES inferred ¹⁴
16	LEP	Leptin	Protein Coding	4.95	DISEASES inferred ¹⁴
17	NALCN	Sodium Leak Channel, Non-Selective	Protein Coding	4.88	DISEASES inferred ¹⁴
18	ARMCX3-AS1	ARMCX3 Antisense RNA 1	RNA Gene	4.84	DISEASES inferred ¹⁴
19	ZNF221	Zinc Finger Protein 221	Protein Coding	4.83	DISEASES inferred ¹⁴

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Variations for Central Sleep Apnea

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Expression for Central Sleep Apnea

Search GEO for disease gene expression data for Central Sleep Apnea.

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Pathways for Central Sleep Apnea

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GO Terms for Central Sleep Apnea

Biological processes related to Central Sleep Apnea according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	regulation of resting membrane potential	GO:0060075	9.62	NALCN KCNK3
2	negative regulation of lipid storage	GO:0010888	9.56	LEP CRP
3	angiotensin maturation	GO:0002003	9.46	REN ACE
4	eating behavior	GO:0042755	9.43	LEP HCRT ACE
5	regulation of blood pressure	GO:0008217	9.23	REN NPPB LEP ACE