MCID: CNT015
MIFTS: 47

Central Sleep Apnea

Categories: Mental diseases, Neuronal diseases, Respiratory diseases

Aliases & Classifications for Central Sleep Apnea

MalaCards integrated aliases for Central Sleep Apnea:

Name: Central Sleep Apnea 12 15
Central Sleep Apnea Syndrome 12 29 6 71
Sleep Apnea, Central 43 71
Central Sleep Apnea, Primary 71
Primary Central Sleep Apnea 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9220
MeSH 43 D020182
NCIt 49 C116046
UMLS 71 C0520680 C0751762 C3887547

Summaries for Central Sleep Apnea

Disease Ontology : 12 A sleep apnea that is characterized by a malfunction of the basic neurological controls for breathing rate and the failure to give the signal to inhale, causing the individual to miss one or more cycles of breathing.

MalaCards based summary : Central Sleep Apnea, also known as central sleep apnea syndrome, is related to sleep apnea and mixed sleep apnea, and has symptoms including apnea An important gene associated with Central Sleep Apnea is CHAT (Choline O-Acetyltransferase), and among its related pathways/superpathways are Oxytocin signaling pathway and Agents Acting on the Renin-Angiotensin System Pathway, Pharmacodynamics. The drugs Zopiclone and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and spinal cord, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 74 Central sleep apnea (CSA) or central sleep apnea syndrome (CSAS) is a sleep-related disorder in which... more...

Related Diseases for Central Sleep Apnea

Diseases in the Sleep Apnea family:

Central Sleep Apnea

Diseases related to Central Sleep Apnea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 273)
# Related Disease Score Top Affiliating Genes
1 sleep apnea 31.1 REN PHOX2B NPPB NOS3 LEP HCRT
2 mixed sleep apnea 30.9 SRC HCRT
3 congestive heart failure 30.3 REN NPPB NPPA NOS3 CRP ACE
4 fabry disease 30.2 NPPB NOS3 CRP
5 atrial standstill 1 30.1 NPPB NPPA ACE
6 left bundle branch hemiblock 30.1 NPPB CRP ACE
7 aspiration pneumonia 30.0 CRP CHAT ACE
8 coronary heart disease 1 30.0 NPPB NOS3 CRP ACE
9 systolic heart failure 29.9 NPPB NPPA NOS3 HSPB7 CRP ACE
10 pulmonary disease, chronic obstructive 29.9 SRC NPPB CRP ACE
11 heart disease 29.9 REN NPPB NPPA NOS3 LEP CRP
12 atherosclerosis susceptibility 29.7 NOS3 LEP CRP ACE
13 diabetic neuropathy 29.7 REN LEP ACE
14 hypertensive heart disease 29.5 REN NPPB NPPA ACE
15 mitral valve insufficiency 29.5 REN NPPB NPPA CRP ACE
16 migraine with or without aura 1 29.4 NOS3 LEP HCRT CRP ACE
17 heart valve disease 29.3 REN NPPB NPPA CRP ACE
18 major depressive disorder 29.3 LEP HCRT CRP ACE
19 atrial fibrillation 29.3 REN NPPB NPPA NOS3 CRP ACE
20 carotid stenosis 29.3 REN NOS3 CRP ACE
21 liver cirrhosis 29.3 REN NPPA LEP CRP
22 pulmonary hypertension 29.2 REN NPPB NPPA NOS3 CRP ACE
23 hypothyroidism 29.2 REN LEP CRP ACE
24 respiratory failure 29.2 REN NPPB NPPA HCRT CRP CHAT
25 end stage renal failure 29.2 REN NPPB NPPA LEP CRP ACE
26 sleep disorder 29.2 REN LEP HCRT FXYD1 CRP ACE
27 chronic kidney disease 29.1 REN NPPB NPPA NOS3 LEP CRP
28 cerebrovascular disease 29.1 REN NPPB NPPA LEP CRP ACE
29 kidney disease 29.1 REN NPPB NPPA NOS3 LEP CRP
30 pulmonary edema 29.0 REN NPPB NPPA NOS3 CRP ACE
31 dilated cardiomyopathy 29.0 REN NPPB NPPA NOS3 HSPB7 CRP
32 stroke, ischemic 28.5 SRC REN NPPB NPPA NOS3 CRP
33 diabetes mellitus, noninsulin-dependent 28.3 SRC REN NOS3 LEP CRP ACE
34 myocardial infarction 28.2 SRC REN NPPB NPPA NOS3 LEP
35 apnea, obstructive sleep 27.0 REN PHOX2B NOS3 MPP5 LEP HCRT
36 idiopathic alveolar hypoventilation syndrome 12.0
37 chiari malformation 11.7
38 chiari malformation type i 11.7
39 chiari malformation type ii 11.6
40 chronic mountain sickness 10.4 NPPB NOS3
41 cardiogenic shock 10.4 NPPB CRP
42 chronic thromboembolic pulmonary hypertension 10.4 NPPB CRP
43 vasculogenic impotence 10.4 NPPA ACE
44 hypoplastic left heart syndrome 10.3 NPPB NPPA LEP
45 atypical depressive disorder 10.3 LEP CRP
46 hydrops of gallbladder 10.3 NPPB CRP
47 mediastinum teratoma 10.3 CRP ACE
48 acute dacryoadenitis 10.3 CRP ACE
49 pulmonary valve insufficiency 10.3 NPPB ACE
50 apnea, central sleep 10.3

Graphical network of the top 20 diseases related to Central Sleep Apnea:



Diseases related to Central Sleep Apnea

Symptoms & Phenotypes for Central Sleep Apnea

UMLS symptoms related to Central Sleep Apnea:


apnea

MGI Mouse Phenotypes related to Central Sleep Apnea:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.96 ACE CHAT HCRT HSPB7 LEP MPP5
2 cardiovascular system MP:0005385 9.93 ACE CABP4 CHAT CRP FXYD1 HCRT
3 muscle MP:0005369 9.56 CHAT FXYD1 HCRT HSPB7 LEP NOS3
4 respiratory system MP:0005388 9.17 CHAT HCRT HSPB7 LEP NOS3 PHOX2B

Drugs & Therapeutics for Central Sleep Apnea

Drugs for Central Sleep Apnea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 85)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zopiclone Approved Phase 4 43200-80-2 5735
2
tannic acid Approved Phase 4 1401-55-4
3
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
4
Trazodone Approved, Investigational Phase 4 19794-93-5 5533
5
Losartan Approved Phase 4 114798-26-4 3961
6
Angiotensin II Approved, Investigational Phase 4 68521-88-0, 11128-99-7, 4474-91-3 172198
7
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
8
Opium Approved, Illicit Phase 4 8008-60-4
9
Loperamide Approved Phase 4 53179-11-6 3955
10
Diphenhydramine Approved, Investigational Phase 4 58-73-1, 147-24-0 3100
11
Zolpidem Approved Phase 4 82626-48-0 5732
12
Promethazine Approved, Investigational Phase 4 60-87-7 4927
13 Serotonin Uptake Inhibitors Phase 4
14 Antidepressive Agents Phase 4
15 Anti-Arrhythmia Agents Phase 4
16 Angiotensinogen Phase 4
17 Angiotensin Receptor Antagonists Phase 4
18 Angiotensin II Type 1 Receptor Blockers Phase 4
19 Giapreza Phase 4
20 Antihypertensive Agents Phase 4
21 Analgesics, Opioid Phase 4
22 Gastrointestinal Agents Phase 4
23 Respiratory System Agents Phase 4
24 Antidiarrheals Phase 4
25 Opium Poppy Phase 4
26 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
27 Antitussive Agents Phase 4
28 Hypnotics and Sedatives Phase 4
29 GABA Agonists Phase 4
30 GABA-A Receptor Agonists Phase 4
31 GABA Agents Phase 4
32
Desogestrel Approved Phase 2, Phase 3 54024-22-5 40973
33
Fluoxetine Approved, Vet_approved Phase 3 54910-89-3 3386
34
Acetazolamide Approved, Vet_approved Phase 3 59-66-5 1986
35
Buspirone Approved, Investigational Phase 3 36505-84-7 2477
36 Contraceptives, Oral Phase 2, Phase 3
37 Hormone Antagonists Phase 2, Phase 3
38 Contraceptive Agents Phase 2, Phase 3
39 Progestins Phase 2, Phase 3
40 Hormones Phase 2, Phase 3
41 Cytochrome P-450 Enzyme Inhibitors Phase 3
42 Cytochrome P-450 CYP2D6 Inhibitors Phase 3
43 Central Nervous System Depressants Phase 3
44 Neurotransmitter Agents Phase 3
45 Natriuretic Agents Phase 3
46 Anticonvulsants Phase 3
47 Carbonic Anhydrase Inhibitors Phase 3
48 diuretics Phase 3
49 Serotonin Receptor Agonists Phase 3
50 Tranquilizing Agents Phase 3

Interventional clinical trials:

(show top 50) (show all 97)
# Name Status NCT ID Phase Drugs
1 Adaptative Servoventilation Compliance in Left Ventricular Dysfunction Patients With Central Sleep Apnea: Benefit of One Month Hypnotic (Zopiclone) Versus Placebo Unknown status NCT02820441 Phase 4 Zopiclone;Placebo
2 Cardiac Resynchronisation Therapy in Combination With Overdrive Pacing in the Treatment of Central Sleep Apnea in CHF Completed NCT00551499 Phase 4
3 Treatment of Sleep-Disordered Breathing With Predominant Central Sleep Apnea by Adaptive Servo Ventilation in Patients With Heart Failure Completed NCT00733343 Phase 4
4 Comparison of Therapeutic Oxygen Versus Medical Air for the Treatment of Central Sleep Apnea in Infants and Children With Prader Willi Syndrome: A Proof of Concept Study Recruiting NCT03031626 Phase 4
5 A Multi-Centre, Randomized Study to Assess the Effects of Adaptive Servo Ventilation (ASV) on Survival and Frequency of Hospital Admissions in Patients With Heart Failure (HF) and Sleep Apnea (SA)-The ADVENT-HF Trial Recruiting NCT01128816 Phase 4
6 Evaluation of Nocturnal Oxygen Needs in the Treatment of Central Sleep Apnea in Patients With Chronic Heart Failure. Recruiting NCT03254212 Phase 4
7 Oxygen Versus PAP for Treatment of Sleep Apnea in Chronic Heart Failure Recruiting NCT01807897 Phase 4
8 Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury Recruiting NCT02922894 Phase 4 Trazodone;Placebo
9 Effect of Angiotensin Receptor Blockers on Periodic Breathing During Sleep in Hypoxia Active, not recruiting NCT03335904 Phase 4 Losartan;Placebo
10 Effect of Acetazolamide on Central Sleep Apnea Related to Opium Consumption Enrolling by invitation NCT02371473 Phase 4 Acetazolamide-placebo;Placebo-acetazolamide
11 Central Sleep Apnea: Physiologic Mechanisms to Inform Treatment Not yet recruiting NCT04118387 Phase 4 Acetazolamide + supplemental oxygen + PAP therapy;Zolpidem + PAP therapy;Buspirone + PAP therapy
12 Effect of Servo-Ventilation on CO2 Regulation and Heart Rate Variability Not yet recruiting NCT03890939 Phase 4
13 Bilevel Positive Pressure Ventilation (BIPAP)in Patients With Sleep Disorders Breathing (SDB)and Congestive Heart Failure (CHF):Comparison of Two Diagnostic Methods Unknown status NCT01501734 Phase 3
14 Efficacy of Fluoxetine Against Seizure-induced Central Apneas : a Randomized Placebo-controled Double-blind Trial. Completed NCT02569970 Phase 3 fluoxetine 20 mg;placebo 20 mg
15 Assessment of Desogestrel for a Pharmacological Recovery of Ventilatory Activity in Congenital Central Hypoventilation Syndrome - Ondine Syndrome Completed NCT01243697 Phase 2, Phase 3 desogestrel
16 The Impact of Low Flow Nocturnal Oxygen Therapy on Hospital Admissions and Mortality in Patients With Heart Failure and Central Sleep Apnea (LOFT-HF) Recruiting NCT03745898 Phase 3 Oxygen
17 Buspirone as a Potential Treatment for Recurrent Central Apneas Terminated NCT00746954 Phase 3 Acetazolamide;Buspirone
18 High-Flow-Therapy for the Treatment of Cheyne-Stokes-Respiration in Chronic Heart Failure Terminated NCT03102827 Phase 3 Oxygen
19 Dynamic Carbon Dioxide Administration for Central Sleep Apnoea in Heart Failure Unknown status NCT01041924 Phase 2
20 Safety and Efficacy Evaluation of Respicardia Therapy for Central Sleep Apnea Completed NCT01124370 Phase 2
21 Improving Sleep and Functioning in Veterans With Posttraumatic Stress Disorder Not yet recruiting NCT04007796 Phase 2
22 Outcome and Treatment of Complex Sleep Apnea Withdrawn NCT01137214 Phase 2
23 A Study to Evaluate the Efficacy of Seattle-PAP for the Respiratory Support of Premature Infants Completed NCT02210026 Phase 1
24 Interface Selection for Adaptive Servo Ventilation: A Randomized Controlled Study Unknown status NCT02919930
25 Effect of Adaptive Servoventilation on Cardiac Function, Exercise Tolerance and Quality of Life in Patients With Chronic Heart Failure and Cheyne-Stokes Respiration Unknown status NCT01212705
26 PHOX2B Mutation-Confirmed Congenital Central Hypoventilation Syndrome in A Chinese Family: Presentations From Newborn to Adulthood Unknown status NCT00652964
27 Sleep Breathing Disorders, a Main Trigger for Cardiac ARythmias in Type I Myotonic Dystrophy ? Unknown status NCT02375087
28 Therapeutic Effect of Desogestrel on Ventilatory Control in Patients With Congenital Central Hypoventilation Syndrome Unknown status NCT01500473 Desogestrel
29 Central Apnoeas in the Course of Transient Ischemic Attack/Ischemic Stroke: Clinical, Prognostic, Pathophysiological Elements. Unknown status NCT01723189
30 Diagnosis And Treatment of Sleep Apnea in Patient With Heart Failure DASAP-HF Study Unknown status NCT02620930
31 Non-Invasive Measurement of Respiratory Effort Unknown status NCT00528749
32 Observational and Transversal Study of Patients Treated in "Real Life"Conditions With Adaptive Servo-Ventilation Completed NCT02429986
33 Bilevel Versus Servoventilation in Complex Sleep Apnea Completed NCT01609244
34 A Randomized Trial Evaluating the Safety and Effectiveness of the remedē® System in Patients With Central Sleep Apnea Completed NCT01816776
35 Pre-operative PSG Assessment of Cardiac Surgery Inpatients Completed NCT00922168
36 Comparison of Adaptive Servo Ventilation(Bipap® Auto SV Advanced) and Oxgen Therapy in Chronic Heart Failure Patients Complicated With Central Sleep Apnea Completed NCT01187823
37 A Multi-Center Study to Assess the Performance of the Saturation Pattern Detection (SPD) Software Algorithm. Completed NCT00775346
38 BiPAP (Automatic Servo Ventilation) autoSV Advanced in Central Apnea Patients Completed NCT01199042
39 Effect of Heart Valve Replacement on Cheyne-Stokes Respiration in Patients With Rheumatic Heart Disease Completed NCT01426776
40 Effectiveness of Adaptive Servoventilation (ASV) in Patients With Central Sleep Apnea Due to Chronic Opioid Use Completed NCT01462084
41 Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude. Completed NCT03368352 Early Phase 1
42 Evaluation of Software Enhancements to the Respironics BiPAP autoSV Device Completed NCT00720213
43 Comparison of the Somnarus Sleep Apnea Diagnostic Technology SomnaPatch With Polysomnography in Sleep Disordered Breathing Completed NCT02034175
44 Crossover Comparison of Treatment With Continuous Positive Airway Pressure and Treatment With Adaptive Servo Ventilation (SOMNOventCR) in Patients With Underlying Heart Disease, Combined Obstructive Sleep Apnea and Cheyne-Stokes Respiration. Completed NCT00811668
45 Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude Completed NCT03588676
46 Different Loop Gain Phenotypes in Patients With Chronic Systolic Heart Failure and Periodic Breathing Completed NCT03532412
47 BiPAP for Cardiomyopathy With Central Sleep Apnea Completed NCT00282789
48 Evaluation Eines Leg Fluid Shift Und Erörterung Der hämodynamischen Und Respiratorischen Auswirkungen Auf Patienten Mit Chronischer Herzinsuffizienz Und Obstruktiver Oder Zentraler Schlafapnoe Completed NCT03092388
49 Late-onset, Insidious Course and Invasive Treatment of Congenital Central Hypoventilation Syndrome in a Case With the Phox2B Mutation Completed NCT01225679
50 Evaluation of the Philips Respironics BiPAP autoSV Devices in Subjects With Sleep Disorders. Completed NCT01626989

Search NIH Clinical Center for Central Sleep Apnea

Cochrane evidence based reviews: sleep apnea, central

Genetic Tests for Central Sleep Apnea

Genetic tests related to Central Sleep Apnea:

# Genetic test Affiliating Genes
1 Central Sleep Apnea Syndrome 29

Anatomical Context for Central Sleep Apnea

MalaCards organs/tissues related to Central Sleep Apnea:

40
Heart, Kidney, Spinal Cord, Brain, Lung, Eye, Tongue

Publications for Central Sleep Apnea

Articles related to Central Sleep Apnea:

(show top 50) (show all 1015)
# Title Authors PMID Year
1
Sleep Breathing Disorders in Heart Failure. 61
31735314 2020
2
Features of Marfan syndrome not listed in the Ghent nosology - The Dark Side of the Disease. 61
31829751 2019
3
Phrenic Nerve Stimulation for the Treatment of Central Sleep Apnea: A Pooled Cohort Analysis. 61
31855160 2019
4
Continuous Positive Airway Pressure and Adaptive Servoventilation in Heart Failure Patients With Central Sleep Apnea With Cheyne Stokes Respiration: Are They Useful in Ameliorating Cardiac Systolic Dysfunction? 61
31855155 2019
5
Effect of Treatment of Central Sleep Apnea/Cheyne-Stokes Respiration on Left Ventricular Ejection Fraction in Heart Failure: A Network Meta-Analysis. 61
31855167 2019
6
Chronic Opioid Therapy and Sleep: An American Academy of Sleep Medicine Position Statement. 61
31739858 2019
7
Association of Valproic Acid With Central Sleep Apnea Syndrome: Two Case Reports. 61
31725092 2019
8
Phrenic Nerve Stimulation for the Treatment of Central Sleep Apnea: A Pooled Cohort Analysis. 61
31685094 2019
9
Emergence of Central Sleep Apnea Events After Maxillomandibular Advancement Surgery for Obstructive Sleep Apnea. 61
31302064 2019
10
Central sleep apnea in children with obstructive sleep apnea syndrome and improvement following adenotonsillectomy. 61
31373175 2019
11
A contemporary review of obstructive sleep apnea. 61
31589188 2019
12
Sleep-Disordered Breathing in Pediatric Patients With Rett Syndrome. 61
31596210 2019
13
Role of sleep study in children with Chiari malformation and sleep disordered breathing. 61
31372737 2019
14
Biallelic loss-of-function P4HTM gene variants cause hypotonia, hypoventilation, intellectual disability, dysautonomia, epilepsy, and eye abnormalities (HIDEA syndrome). 61
30940925 2019
15
Long-term efficacy and safety of phrenic nerve stimulation for the treatment of central sleep apnea. 61
31634407 2019
16
Association of Valproic Acid With Central Sleep Apnea Syndrome: Two Case Reports. 61
31609807 2019
17
What is the remaining status of adaptive servo-ventilation? The results of a real-life multicenter study (OTRLASV-study) : Adaptive servo-ventilation in real-life conditions. 61
31665026 2019
18
The Effect of Positive Airway Pressure Treatment of Obstructive and Central Sleep Apnea on the Recurrence of Atrial Fibrillation/Flutter Postintervention. 61
31596211 2019
19
Effect of Treatment of Central Sleep Apnea/Cheyne-Stokes Respiration on Left Ventricular Ejection Fraction in Heart Failure: A Network Meta-Analysis. 61
31662181 2019
20
Sleep Apnea and Chronic Kidney Disease: A State-of-the-Art Review. 61
31542452 2019
21
New-generation positional therapy in patients with positional central sleep apnea. 61
31302742 2019
22
High Incidence of Sleep-Related Breathing Disorders in Children with Down Syndrome Referred to a High-Altitude Sleep Laboratory. 61
31259618 2019
23
Sleep apnea and the heart. 61
31509499 2019
24
Treatment and persistence/recurrence of sleep-disordered breathing in children with Down syndrome. 61
31172656 2019
25
Interventional techniques to increase implantation success of transvenous phrenic nerve stimulation for central sleep apnea treatment. 61
31407159 2019
26
Detecting central sleep apnea in adult patients using WatchPAT-a multicenter validation study. 61
31402439 2019
27
Ticagrelor-Associated Shift From Obstructive to Central Sleep Apnea: A Case Report. 61
31482841 2019
28
Anesthetic management in corticobasal degeneration with central sleep apnea: A case report. 61
31501782 2019
29
Unattended sleep study in screening for sleep apnea in the acute phase of ischemic stroke. 61
31751906 2019
30
Extended evaluation of the efficacy of a proactive forced oscillation technique-based auto-CPAP algorithm. 61
31388800 2019
31
How to organise teaching activities for the scoring of cardiorespiratory polygraphies? Experiences from three Swedish Sleep Society teaching courses. 61
30246416 2019
32
Nocturnal supports for patients with central sleep apnea and heart failure: a systemic review and network meta-analysis of randomized controlled trials. 61
31475207 2019
33
Sleep apnea assessment using declination duration-based global metrics from unobtrusive fiber optic sensors. 61
31361598 2019
34
Heterogeneity of Periodic Limb Movements Associated With Central Sleep Apnea in Heart Failure Patients. 61
31029412 2019
35
Sleep Disorders in Hereditary Ataxias. 61
31342187 2019
36
[Association between mixed sleep apnea and treatment-emergent central sleep apnea]. 61
31269581 2019
37
Diagnosis and management of central sleep apnea syndrome. 61
31014146 2019
38
Association of serious adverse events with Cheyne-Stokes respiration characteristics in patients with systolic heart failure and central sleep apnoea: A SERVE-Heart Failure substudy analysis. 61
31218793 2019
39
Phrenic nerve stimulation in patients with central sleep apnea: a single‑center experience from pilot and pivotal trials evaluating the remedē System. 61
30964196 2019
40
Successful screening of sleep-disordered breathing using a pacemaker-based algorithm in Japan. 61
30630655 2019
41
Therapeutic effects of CPAP on cognitive impairments associated with OSA. 61
31111204 2019
42
How to implant a phrenic nerve stimulator for treatment of central sleep apnea? 61
30834611 2019
43
Diagnosis, management and pathophysiology of central sleep apnea in children. 61
30170958 2019
44
Tongue Stabilizing Device-Emergent Central Sleep Apnea: A Case Report. 61
30952219 2019
45
Persistent Central Apnea and Long-Term Outcome After Posterior Fossa Decompressive Surgery for Arnold Chiari Type 1 Malformation in a Pediatric Patient. 61
30952227 2019
46
Pierre Robin Sequence. 61
30851756 2019
47
Apneas of Heart Failure and Phenotype-Guided Treatments: Part One: OSA. 61
31047953 2019
48
Relationship of stroke volume to different patterns of Cheyne-Stokes respiration in heart failure. 61
30946471 2019
49
Influenza virus and factors that are associated with ICU admission, pulmonary co-infections and ICU mortality. 61
30481669 2019
50
Beneficial effects of adaptive servo-ventilation on natriuretic peptides and diastolic function in acute heart failure patients with preserved ejection fraction and sleep-disordered breathing. 61
29948858 2019

Variations for Central Sleep Apnea

ClinVar genetic disease variations for Central Sleep Apnea:

6 ‎‎ ‎‎
# Gene Name Type Significance ClinVarId dbSNP ID GRCh37 Pos GRCh38 Pos
1 CHAT NM_020549.4(CHAT):c.2081C>G (p.Ser694Cys)SNV Pathogenic 523529 rs201439531 10:50872926-50872926 10:49664880-49664880
2 CHAT NM_020549.4(CHAT):c.1061C>T (p.Thr354Met)SNV Conflicting interpretations of pathogenicity 523528 rs769234940 10:50835781-50835781 10:49627735-49627735

Expression for Central Sleep Apnea

Search GEO for disease gene expression data for Central Sleep Apnea.

Pathways for Central Sleep Apnea

Pathways related to Central Sleep Apnea according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.91 SRC NPPB NPPA NOS3
2
Show member pathways
11.03 REN NOS3 ACE
3 10.64 REN NPPA ACE

GO Terms for Central Sleep Apnea

Cellular components related to Central Sleep Apnea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.77 SRC REN NPPB NPPA NOS3 MPP5
2 extracellular region GO:0005576 9.76 REN NPPB NPPA LEP HCRT CRP
3 caveola GO:0005901 8.8 SRC NOS3 FXYD1

Biological processes related to Central Sleep Apnea according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 neuropeptide signaling pathway GO:0007218 9.69 NPPB NPPA HCRT
2 positive regulation of cold-induced thermogenesis GO:0120162 9.67 PHOX2B LEP HCRT
3 regulation of nitric-oxide synthase activity GO:0050999 9.54 NOS3 LEP
4 amyloid-beta metabolic process GO:0050435 9.52 REN ACE
5 negative regulation of systemic arterial blood pressure GO:0003085 9.48 NPPB NPPA
6 angiotensin maturation GO:0002003 9.46 REN ACE
7 regulation of vascular permeability GO:0043114 9.43 SRC NPPB
8 cGMP biosynthetic process GO:0006182 9.4 NPPB NPPA
9 negative regulation of potassium ion transport GO:0043267 9.37 NOS3 HCRT
10 receptor guanylyl cyclase signaling pathway GO:0007168 9.32 NPPB NPPA
11 negative regulation of lipid storage GO:0010888 9.26 LEP CRP
12 ovulation from ovarian follicle GO:0001542 9.16 NOS3 LEP
13 regulation of blood vessel diameter GO:0097746 9.13 NPPB NOS3 ACE
14 regulation of blood pressure GO:0008217 9.1 REN NPPB NPPA NOS3 LEP ACE

Molecular functions related to Central Sleep Apnea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 ion channel binding GO:0044325 9.43 SRC FXYD1 CABP4
2 hormone activity GO:0005179 9.33 NPPB NPPA LEP
3 signaling receptor binding GO:0005102 9.02 SRC REN NPPB NPPA LEP
4 hormone receptor binding GO:0051427 8.96 NPPB NPPA

Sources for Central Sleep Apnea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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