Home
User Guide
What's in a MalaCard Search Guide Our Sources
Analysis Tools
GeneCards GeneAnalytics GeneAlaCart PathCards VarElect TGex
News and Views Disease Lists/Categories
About
About MalaCards Our Publications Academic Licensing Weizmann Institute LifeMap Discovery® Terms of Use MalaCards Team
MCID: CNT015
MIFTS: 49

Central Sleep Apnea

Categories: Mental diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
Sources

Aliases & Classifications for Central Sleep Apnea

About this section

MalaCards integrated aliases for Central Sleep Apnea:

Name: Central Sleep Apnea 12 15
Central Sleep Apnea Syndrome 12 29 6 73
Sleep Apnea, Central 44 73
Central Sleep Apnea, Primary 73
Primary Central Sleep Apnea 12

Classifications:

MalaCards categories:
Anatomical: Mental diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:9220
ICD10 33 G47.31
ICD9CM 35 327.21
MeSH 44 D020182
SNOMED-CT 68 9741000119101
Sources

Summaries for Central Sleep Apnea

About this section
Disease Ontology : 12 A sleep apnea that is characterized by a malfunction of the basic neurological controls for breathing rate and the failure to give the signal to inhale, causing the individual to miss one or more cycles of breathing.

MalaCards based summary : Central Sleep Apnea, also known as central sleep apnea syndrome, is related to sleep apnea and systolic heart failure, and has symptoms including apnea An important gene associated with Central Sleep Apnea is CHAT (Choline O-Acetyltransferase), and among its related pathways/superpathways are Vascular smooth muscle contraction and Prolactin Signaling Pathway. The drugs Zopiclone and Olanzapine have been mentioned in the context of this disorder. Affiliated tissues include heart, eye and spinal cord, and related phenotypes are limbs/digits/tail and muscle

Wikipedia : 76 Central sleep apnea (CSA) or central sleep apnea syndrome (CSAS) is a sleep-related disorder in which... more...

Sources

Related Diseases for Central Sleep Apnea

About this section

Diseases in the Sleep Apnea family:

Central Sleep Apnea

Diseases related to Central Sleep Apnea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 70)
# Related Disease Score Top Affiliating Genes
1 sleep apnea 32.2 LEP NOS3 NPPB
2 systolic heart failure 30.6 HSPB7 NPPB
3 chronic kidney failure 30.0 LEP NPPA NPPB
4 pulmonary hypertension 29.6 NOS3 NPPA NPPB
5 dilated cardiomyopathy 29.1 HSPB7 NOS3 NPPA NPPB
6 idiopathic alveolar hypoventilation syndrome 11.7
7 syndrome of inappropriate antidiuretic hormone 10.5 NPPA NPPB
8 mitral valve stenosis 10.5 NPPA NPPB
9 idiopathic edema 10.4 NPPA NPPB
10 syncope 10.4 NPPA NPPB
11 congestive heart failure 10.4
12 mitral valve insufficiency 10.4 NPPA NPPB
13 chronic mountain sickness 10.3 NOS3 NPPB
14 apnea, obstructive sleep 10.3
15 toxic myocarditis 10.3 NOS3 NPPB
16 renal artery disease 10.3 NOS3 NPPA
17 vasculogenic impotence 10.3 NOS3 NPPA
18 diastolic heart failure 10.3 NOS3 NPPB
19 pericardial effusion 10.3 NPPA NPPB
20 ischemic heart disease 10.3 NOS3 NPPB
21 renovascular hypertension 10.2 NOS3 NPPA
22 atrial fibrillation 10.1
23 heart disease 10.1
24 chiari malformation 10.1
25 carotid artery occlusion 10.1 CA1 NOS3
26 cerebritis 10.1
27 mitral valve disease 10.1 NOS3 NPPA
28 pulmonary edema 10.0 NOS3 NPPB
29 muscle hypertrophy 10.0 LEP NPPA
30 hypoplastic left heart syndrome 10.0 LEP NPPA NPPB
31 kidney disease 10.0
32 type i 10.0
33 aortic valve disease 2 10.0 NPPA NPPB
34 stiff-person syndrome 9.9
35 mixed sleep apnea 9.9
36 hypothyroidism 9.9
37 pharyngitis 9.9
38 cervicitis 9.9
39 sleep disorder 9.9
40 arteries, anomalies of 9.8 LEP NOS3 NPPB
41 glucose metabolism disease 9.8 LEP NOS3
42 apnea, central sleep 9.8
43 multiple sclerosis 9.8
44 laryngomalacia 9.8
45 central hypoventilation syndrome, congenital 9.8
46 joubert syndrome 1 9.8
47 vici syndrome 9.8
48 coronary heart disease 1 9.8
49 anxiety 9.8
50 myocardial infarction 9.8

Graphical network of the top 20 diseases related to Central Sleep Apnea:



Diseases related to Central Sleep Apnea
Sources

Symptoms & Phenotypes for Central Sleep Apnea

About this section

UMLS symptoms related to Central Sleep Apnea:


apnea

MGI Mouse Phenotypes related to Central Sleep Apnea:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.46 CHAT LEP NOS3 SRC
2 muscle MP:0005369 9.35 HSPB7 LEP NOS3 NPPA CHAT
3 respiratory system MP:0005388 9.02 HSPB7 LEP NOS3 SRC CHAT
Sources

Drugs & Therapeutics for Central Sleep Apnea

About this section

Drugs for Central Sleep Apnea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 102)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zopiclone Approved Phase 4 43200-80-2 5735
2
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
3
Menthol Approved Phase 4 2216-51-5 16666
4
Acetazolamide Approved, Vet_approved Phase 4,Phase 3 59-66-5 1986
5
Remifentanil Approved Phase 4 132875-61-7 60815
6
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
7
Trazodone Approved, Investigational Phase 4 19794-93-5 5533
8
Finasteride Approved Phase 4 98319-26-7 57363
9
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
10
Testosterone Approved, Investigational Phase 4 58-22-0 6013
11
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
12
Desflurane Approved Phase 4 57041-67-5 42113
13
Opium Approved, Illicit Phase 4 8008-60-4
14
Loperamide Approved Phase 4 53179-11-6 3955
15
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
16 tannic acid Approved, Nutraceutical Phase 4
17 Analgesics Phase 4,Phase 3,Not Applicable
18 Central Nervous System Depressants Phase 4,Phase 3,Not Applicable,Early Phase 1
19 Narcotics Phase 4,Phase 3,Not Applicable
20 Analgesics, Opioid Phase 4,Phase 3,Not Applicable
21 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
22 Hypnotics and Sedatives Phase 4,Phase 3
23 Serotonin Agents Phase 4,Phase 3
24 Serotonin Uptake Inhibitors Phase 4,Phase 3
25 Gastrointestinal Agents Phase 4
26 Neurotransmitter Agents Phase 4,Phase 3,Not Applicable
27 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3
28 Anesthetics Phase 4,Phase 3,Not Applicable
29 Hormone Antagonists Phase 4,Phase 2,Phase 3
30 Anesthetics, General Phase 4,Phase 3
31 Anesthetics, Intravenous Phase 4,Phase 3
32 Tranquilizing Agents Phase 4,Phase 3
33 Hormones Phase 4,Phase 2,Phase 3
34 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
35 Antidepressive Agents Phase 4,Phase 3
36 Antidepressive Agents, Second-Generation Phase 4,Phase 3
37 Antiemetics Phase 4
38 Antipsychotic Agents Phase 4
39 Psychotropic Drugs Phase 4,Phase 3
40 Autonomic Agents Phase 4,Not Applicable
41 diuretics Phase 4,Phase 3,Not Applicable
42 5-alpha Reductase Inhibitors Phase 4
43 Adjuvants, Anesthesia Phase 4
44 Natriuretic Agents Phase 4,Phase 3
45 Steroid Synthesis Inhibitors Phase 4
46 Anesthetics, Inhalation Phase 4
47 Anti-Anxiety Agents Phase 4,Phase 3
48 Platelet Aggregation Inhibitors Phase 4
49 Anticonvulsants Phase 4,Phase 3
50 Carbonic Anhydrase Inhibitors Phase 4,Phase 3

Interventional clinical trials:

(show top 50) (show all 107)
# Name Status NCT ID Phase Drugs
1 Benefit of One Month Zopiclone Intake on Adaptative Servoventilation Compliance Unknown status NCT02820441 Phase 4 Zopiclone;Placebo
2 Cardiac Resynchronisation Therapy in Combination With Overdrive Pacing in the Treatment of Central Sleep Apnea in CHF Completed NCT00551499 Phase 4
3 Treatment of Predominant Central Sleep Apnoea by Adaptive Servo Ventilation in Patients With Heart Failure Completed NCT00733343 Phase 4
4 Substudy on the Mechanistic Plausibility of the Clinical Benefits of Adaptive Servo-ventilation Completed NCT01164592 Phase 4
5 An Investigation of the Sleep Architecture and Consequent Cognitive Changes in Olanzapine-Treated Depressed Patients Completed NCT00520507 Phase 4 Olanzapine;Placebo
6 Oxygen Versus Medical Air for Treatment of CSA in Prader Will Syndrome Recruiting NCT03031626 Phase 4
7 Effect of Adaptive Servo Ventilation (ASV) on Survival and Hospital Admissions in Heart Failure Recruiting NCT01128816 Phase 4
8 Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury Recruiting NCT02922894 Phase 4 Trazodone;Placebo
9 Sleep Apnea in Elderly Recruiting NCT02703220 Phase 4 Acetazolamide;Finasteride
10 Short Life Agents in Balanced Anesthesia on Obstructive Sleep Apnea Syndrome Recruiting NCT02717780 Phase 4 Fentanyl and sevoflurane;Remifentanil and desflurane
11 Effect of Acetazolamide on Central Sleep Apnea Related to Opium Consumption Enrolling by invitation NCT02371473 Phase 4 Acetazolamide-placebo;Placebo-acetazolamide
12 Nocturnal Oxygen Needs and Central Sleep Apnea in Patients With Chronic Heart Failure. Not yet recruiting NCT03254212 Phase 4
13 Bilevel Positive Pressure Ventilation (BIPAP)in Patients With Sleep Disorders Breathing (SDB)and Congestive Heart Failure (CHF):Comparison of Two Diagnostic Methods Unknown status NCT01501734 Phase 3
14 Assessment of Desogestrel in Ondine Syndrome Completed NCT01243697 Phase 2, Phase 3 desogestrel
15 Efficacy of Fluoxetine Against Seizure-induced Central Apneas Completed NCT02569970 Phase 3 fluoxetine 20 mg;placebo 20 mg
16 Ketofol vs Propofol for Emergency Department Procedural Sedation and Analgesia Completed NCT01211158 Phase 3 Ketofol;Propofol alone
17 Caffeine for Apnea of Prematurity-Sleep (CAP-S) Study Completed NCT01020357 Phase 3 Caffeine citrate injection;placebo
18 Morphine in Moderate Obstructive Sleep Apnoea Suspended NCT03127800 Phase 3 Morphine sulphate
19 Buspirone as a Potential Treatment for Recurrent Central Apnea Terminated NCT00746954 Phase 3 Acetazolamide;Buspirone
20 Dynamic Carbon Dioxide (CO2) Administration for Sleep Apnoea Unknown status NCT01041924 Phase 2
21 Chronic Evaluation of Respicardia Therapy Completed NCT01124370 Phase 2
22 Safety of Ramelteon in Subjects With Mild to Moderate Obstructive Sleep Apnea Completed NCT00672061 Phase 2 Ramelteon or Placebo
23 Stroke and CPAP Outcome Study 2 Recruiting NCT02809430 Phase 2
24 Effect of Fenofibrate on Sleep Apnea Syndrome Terminated NCT00816829 Phase 2 Placebo;Fenofibrate
25 Outcome and Treatment of Complex Sleep Apnea Withdrawn NCT01137214 Phase 2
26 Effect of Adaptive Servoventilation on Cardiac Function in Chronic Heart Failure and Cheyne-Stokes Respiration Unknown status NCT01212705 Not Applicable
27 Interface Selection for Adaptive Servo Ventilation Unknown status NCT02919930 Not Applicable
28 Opiate Sleep Disordered Breathing Study Unknown status NCT00791674
29 Mechanisms of Pharyngeal Collapse in Sleep Apnea, Study D Unknown status NCT01733784 Not Applicable
30 Pathophysiology of Central Apnoeas in Stroke Patients Unknown status NCT01723189
31 PHOX2B Mutation-Confirmed Congenital Central Hypoventilation Syndrome in A Chinese Family: Presentations From Newborn to Adulthood Unknown status NCT00652964
32 Intrinsic Periodic Pattern of Breathing Unknown status NCT02201875
33 Normal Polysomnography Values in Healthy Children and Adolescents in China Unknown status NCT02761902
34 Effectiveness of Adaptive Servoventilation (ASV) in Patients With Central Sleep Apnea Due to Chronic Opioid Use Completed NCT01462084 Not Applicable
35 PAC-IC-SAS Pilot Study - Central Sleep Apneas Syndrome and Ventricular Function Completed NCT01741337 Not Applicable
36 The Effect of Adaptive Servo Ventilation and Oxygen Therapy in Central Sleep Apnea Patients Completed NCT01187823 Not Applicable
37 Leg Fluid Shift in Patients With Chronic Heart Failure and Obstructive or Central Sleep Apnea Completed NCT03092388 Not Applicable
38 BiPAP for Cardiomyopathy With Central Sleep Apnea Completed NCT00282789 Not Applicable
39 Effect of Heart Valve Replacement on Cheyne-Stokes Respiration Completed NCT01426776 Not Applicable
40 Different Loop Gain Phenotypes in Patients With Chronic Systolic Heart Failure and Periodic Breathing Completed NCT03532412
41 Respicardia, Inc. Pivotal Trial of the remedē System Completed NCT01816776 Not Applicable
42 Mechanisms of Action of Adaptive Servoventilation Completed NCT00976417
43 Bilevel Versus Servoventilation in Complex Sleep Apnea Completed NCT01609244 Not Applicable
44 Comparison of SomnaPatch With Polysomnography in Sleep Disordered Breathing Completed NCT02034175
45 Atrial Fibrillation Recurrence in Sleep Apnea Completed NCT00263757 Not Applicable
46 Comparison of CPAP With SOMNOventCR in Patients With Underlying Heart Disease, Combined OSA and CSR Completed NCT00811668 Not Applicable
47 Bipap Automatic Servo Ventilation (autoSV) Advanced in Central Apnea Patients Completed NCT01199042 Not Applicable
48 Nocturnal Oxygen Treatment in Heart Failure and Cheyne-Stokes Respiration Completed NCT00338078 Not Applicable
49 Pre-operative Polysomnography Assessment of Cardiac Surgery Inpatients Completed NCT00922168
50 A Multi-Center Study to Assess the Performance of Saturation Patterns. Completed NCT00775346

Search NIH Clinical Center for Central Sleep Apnea

Cochrane evidence based reviews: sleep apnea, central

Sources

Genetic Tests for Central Sleep Apnea

About this section

Genetic tests related to Central Sleep Apnea:

# Genetic test Affiliating Genes
1 Central Sleep Apnea Syndrome 29
Sources

Anatomical Context for Central Sleep Apnea

About this section

MalaCards organs/tissues related to Central Sleep Apnea:

41
Heart, Eye, Spinal Cord, Kidney, Tongue, Testes, Brain
Sources

Publications for Central Sleep Apnea

About this section

Articles related to Central Sleep Apnea:

(show top 50) (show all 328)
# Title Authors Year
1
PRO: Persistent Central Sleep Apnea/Hunter-Cheyne-Stokes Breathing, Despite Best Guideline-Based Therapy of Heart Failure With Reduced Ejection Fraction, Is a Compensatory Mechanism and Should Not Be Suppressed. ( 29860966 )
2018
2
Transient Central Sleep Apnea Runs Triggered by Disorder of Arousal in a Child. ( 29852907 )
2018
3
Microstructural cerebral lesions are associated with the severity of central sleep apnea with Cheyne-Stokes-respiration in heart failure and are modified by PAP-therapy. ( 29102807 )
2018
4
Correlates and Consequences Central Sleep Apnea in a National Sample of U.S. Veterans. ( 29608761 )
2018
5
Central Sleep Apnea - a Rare Cause for Acute Respiratory Insufficiency in Children. Case Report. ( 29868143 )
2018
6
Cycle length identifies obstructive sleep apnea and central sleep apnea in heart failure with reduced ejection fraction. ( 29637409 )
2018
7
Transvenous phrenic nerve stimulation, a novel therapeutic approach for central sleep apnea. ( 29707357 )
2018
8
Natural history of treatment-emergent central sleep apnea on positive airway pressure: A systematic review. ( 29675059 )
2018
9
Sustained 12 Month Benefit of Phrenic Nerve Stimulation for Central Sleep Apnea. ( 29735217 )
2018
10
Increasing cerebral blood flow reduces the severity of central sleep apnea at high altitude. ( 29389246 )
2018
11
Adaptive Servoventilation as Treatment for Central Sleep Apnea Due to High-Altitude Periodic Breathing in Nonacclimatized Healthy Individuals. ( 29641294 )
2018
12
Adaptive servo-ventilation to treat central sleep apnea in heart failure with reduced ejection fraction: the BadA Oeynhausen prospective ASV registry. ( 29654439 )
2018
13
Central Sleep Apnea with Cheyne-Stokes Breathing in Heart Failure - From Research to Clinical Practice and Beyond. ( 29411336 )
2018
14
CON: Persistent Central Sleep Apnea/Hunter-Cheyne-Stokes Breathing, Despite Best Guideline-Based Therapy of Heart Failure With Reduced Ejection Fraction, Is Not a Compensatory Mechanism and Should Be Suppressed. ( 29852913 )
2018
15
Adaptive servo-ventilation and sleep quality in treatment emergent central sleep apnea and central sleep apnea in patients with heart disease and preserved ejection fraction. ( 29372314 )
2018
16
Primary central sleep apnea and anesthesia: a retrospective case series. ( 29717414 )
2018
17
Central Sleep Apnea Post Vagal Nerve Manipulation and Stimulation During Neck Tumor Resection: A Case Report. ( 29621011 )
2018
18
Obstructive Sleep Apnea in a Severely Obese Child With Combined Central Sleep Apnea and Sleep-Related Hypoventilation Disorder Caused by a Medullary Tumor. ( 29852906 )
2018
19
Chiari type 1 malformation associated with central sleep apnea after high dose growth hormone (GH) therapy in a 12-year-old boy: A case report. ( 29403156 )
2018
20
Sleep Complaints and Sleep Architecture in Children With Idiopathic Central Sleep Apnea. ( 28212689 )
2017
21
Emergent central sleep apnea during CPAP therapy-clinical implications. ( 29268465 )
2017
22
Impairment of pulmonary diffusion correlates with hypoxemic burden in central sleep apnea heart failure patients. ( 28467884 )
2017
23
Focus on Functional Delayed Central Sleep Apnea Following Cervical Laminectomy. An Example of Respiratory Dysfunction in Restorative Neurosurgical Procedures. ( 28120077 )
2017
24
Long-Term Experience with First-Generation Implantable Neurostimulation Device in Central Sleep Apnea Treatment. ( 28211952 )
2017
25
Non-Mask-based Therapies for Central Sleep Apnea in Patients with Heart Failure. ( 28477779 )
2017
26
Monitoring of nocturnal central sleep apnea in Heart failure patients using noncontact respiratory differences. ( 29060172 )
2017
27
Evaluation of the central sleep apnea in asymptomatic children with Chiari 1 malformation: an open question. ( 28382434 )
2017
28
Central sleep apnea during continuous positive airway pressure therapy in obstructive sleep apnea patients: from the compliance to adaptation, maladaptation and reflexes. ( 29268457 )
2017
29
Central Sleep Apnea and Stiff Person Syndrome: A Case Report. ( 28358591 )
2017
30
Rapid-eye-movement sleep-predominant central sleep apnea relieved by positive airway pressure: a case report. ( 28483860 )
2017
31
Predominant obstructive or central sleep apnea in patients with atrial fibrillation: influence of characterizing apneas versus apneas and hypopneas. ( 28899542 )
2017
32
Trajectories of Emergent Central Sleep Apnea During CPAP Therapy. ( 28629918 )
2017
33
Central Sleep Apnea in Patients with Congestive Heart Failure. ( 28477776 )
2017
34
Obstructive and Central Sleep Apnea and the Risk of Incident Atrial Fibrillation in a Community Cohort of Men and Women. ( 28668820 )
2017
35
Low leptin concentration may identify heart failure patients with central sleep apnea. ( 28643476 )
2017
36
Relief for Central Sleep Apnea. ( 29164238 )
2017
37
Central sleep apnea: the problem of diagnosis. ( 28153696 )
2017
38
Central Sleep Apnea in Heart Failure: Sleeping With the Wrong Enemy? ( 28335842 )
2017
39
Respiratory drive in patients with chronic heart failure and central sleep apnea: Data from the Daunia Heart Failure Registry. ( 28065692 )
2017
40
Association between central sleep apnea and left ventricular structure: the Multi-Ethnic Study of Atherosclerosis. ( 28220556 )
2017
41
A Potential Novel Mechanism for Vagus Nerve Stimulator-Related Central Sleep Apnea. ( 28961186 )
2017
42
Vertex Rolandic Spikes and Central Sleep Apnea inA aA Newborn. ( 27137362 )
2016
43
Ischemic Lesion Formation in Solitary Tract Nuclei During Central Sleep Apnea With Heart Failure. ( 26948864 )
2016
44
Association of Central Sleep Apnea with Impaired Heart Structure and Cardiovascular Hemodynamics in Patients with Chronic Heart Failure. ( 27558771 )
2016
45
Current treatment approaches and trials in central sleep apnea. ( 26961738 )
2016
46
Central sleep apnea in children: experience at a single center. ( 27823711 )
2016
47
The effect of adaptive servo ventilation (ASV) on objective and subjective outcomes in Cheyne-Stokes respiration (CSR) with central sleep apnea (CSA) in heart failure (HF): A systematic review. ( 26995256 )
2016
48
Probing the prevalence of central sleep apnea in patients with chronic kidney disease. ( 27638724 )
2016
49
Identifying Predictors of Central Sleep Apnea/Cheyne-Stokes Breathing in Chronic Heart Failure: a Pathophysiological Approach. ( 28068279 )
2016
50
Updated Adaptive Servo-Ventilation Recommendations for the 2012 AASM Guideline: "The Treatment of Central Sleep Apnea Syndromes in Adults: Practice Parameters with an Evidence-Based Literature Review and Meta-Analyses". ( 27092695 )
2016
Sources

Variations for Central Sleep Apnea

About this section

ClinVar genetic disease variations for Central Sleep Apnea:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CHAT NM_020549.4(CHAT): c.1061C> T (p.Thr354Met) single nucleotide variant Conflicting interpretations of pathogenicity rs769234940 GRCh37 Chromosome 10, 50835781: 50835781
2 CHAT NM_020549.4(CHAT): c.1061C> T (p.Thr354Met) single nucleotide variant Conflicting interpretations of pathogenicity rs769234940 GRCh38 Chromosome 10, 49627735: 49627735
3 CHAT NM_020549.4(CHAT): c.2081C> G (p.Ser694Cys) single nucleotide variant Pathogenic rs201439531 GRCh37 Chromosome 10, 50872926: 50872926
4 CHAT NM_020549.4(CHAT): c.2081C> G (p.Ser694Cys) single nucleotide variant Pathogenic rs201439531 GRCh38 Chromosome 10, 49664880: 49664880
Sources

Expression for Central Sleep Apnea

About this section
Search GEO for disease gene expression data for Central Sleep Apnea.
Sources

Pathways for Central Sleep Apnea

About this section

Pathways related to Central Sleep Apnea according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Vascular smooth muscle contraction 37
Show member pathways
 12.29 NOS3 NPPB SRC
2
Prolactin Signaling Pathway 1 37
Show member pathways
 12 LEP NOS3 SRC
3
AGE/RAGE pathway 1
11.28 NOS3 SRC
4
Signaling events mediated by PTP1B 1
11.13 LEP SRC
5
Thromboxane A2 receptor signaling 1
11.06 NOS3 SRC
6
AMPK Enzyme Complex Pathway 64
Show member pathways
 11.03 LEP NOS3 SRC
7
Plasma membrane estrogen receptor signaling 1
10.74 NOS3 SRC
8
Differentiation of white and brown adipocyte 1
10.65 HSPB7 LEP
9
Angiogenesis (WikiPathways) 1
10.54 NOS3 SRC
10
Cardiomyocyte Differentiation through BMP Receptors 64
10.3 NPPA NPPB
Sources

GO Terms for Central Sleep Apnea

About this section

Cellular components related to Central Sleep Apnea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 caveola GO:0005901 8.62 NOS3 SRC

Biological processes related to Central Sleep Apnea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 response to insulin GO:0032868 9.48 LEP NPPA
2 response to nutrient levels GO:0031667 9.46 LEP SRC
3 cGMP biosynthetic process GO:0006182 9.43 NPPA NPPB
4 regulation of nitric-oxide synthase activity GO:0050999 9.4 LEP NOS3
5 positive regulation of insulin receptor signaling pathway GO:0046628 9.37 LEP SRC
6 regulation of vascular permeability GO:0043114 9.32 NPPB SRC
7 receptor guanylyl cyclase signaling pathway GO:0007168 9.26 NPPA NPPB
8 ovulation from ovarian follicle GO:0001542 9.16 LEP NOS3
9 regulation of blood vessel size GO:0050880 9.13 NOS3 NPPA NPPB
10 regulation of blood pressure GO:0008217 8.92 LEP NOS3 NPPA NPPB

Molecular functions related to Central Sleep Apnea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.56 LEP NPPA NPPB SRC
2 hormone activity GO:0005179 9.33 LEP NPPA NPPB
3 scaffold protein binding GO:0097110 9.32 NOS3 SRC
4 peptide hormone receptor binding GO:0051428 8.96 LEP NPPA
5 hormone receptor binding GO:0051427 8.8 NPPA NPPB SRC
Sources

Sources for Central Sleep Apnea

About this section
3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Content
Loading form....