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MCID: CNT015
MIFTS: 47

Central Sleep Apnea

Categories: Mental diseases, Neuronal diseases, Respiratory diseases
Genes Variations Tissues Related diseases Publications Pathways Symptoms & Phenotypes Drugs
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Aliases & Classifications for Central Sleep Apnea

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MalaCards integrated aliases for Central Sleep Apnea:

Name: Central Sleep Apnea 12 15
Central Sleep Apnea Syndrome 12 29 6 73
Sleep Apnea, Central 44 73
Central Sleep Apnea, Primary 73
Primary Central Sleep Apnea 12

Classifications:

MalaCards categories:
Anatomical: Mental diseases Neuronal diseases Respiratory diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:9220
MeSH 44 D020182
NCIt 50 C116046
Sources

Summaries for Central Sleep Apnea

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Disease Ontology : 12 A sleep apnea that is characterized by a malfunction of the basic neurological controls for breathing rate and the failure to give the signal to inhale, causing the individual to miss one or more cycles of breathing.

MalaCards based summary : Central Sleep Apnea, also known as central sleep apnea syndrome, is related to sleep apnea and systolic heart failure, and has symptoms including apnea An important gene associated with Central Sleep Apnea is CHAT (Choline O-Acetyltransferase), and among its related pathways/superpathways are Vascular smooth muscle contraction and Prolactin Signaling Pathway. The drugs Zopiclone and Guaifenesin have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and brain, and related phenotypes are limbs/digits/tail and muscle

Wikipedia : 76 Central sleep apnea (CSA) or central sleep apnea syndrome (CSAS) is a sleep-related disorder in which... more...

Sources

Related Diseases for Central Sleep Apnea

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Diseases in the Sleep Apnea family:

Central Sleep Apnea

Diseases related to Central Sleep Apnea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 71)
# Related Disease Score Top Affiliating Genes
1 sleep apnea 32.5 LEP NOS3 NPPB
2 systolic heart failure 30.4 HSPB7 NPPB
3 kidney disease 30.0 NOS3 NPPA NPPB
4 pulmonary hypertension 30.0 NOS3 NPPA NPPB
5 mitral valve insufficiency 30.0 NPPA NPPB
6 chronic kidney failure 29.8 LEP NOS3 NPPA NPPB
7 dilated cardiomyopathy 29.8 HSPB7 NOS3 NPPA NPPB
8 idiopathic alveolar hypoventilation syndrome 11.8
9 congestive heart failure 10.5
10 chiari malformation 10.3
11 atrial fibrillation 10.2
12 heart disease 10.2
13 anterolateral myocardial infarction 10.1 NPPA NPPB
14 syndrome of inappropriate antidiuretic hormone 10.1 NPPA NPPB
15 mitral valve stenosis 10.1 NPPA NPPB
16 idiopathic edema 10.1 NPPA NPPB
17 syncope 10.1 NPPA NPPB
18 apnea, obstructive sleep 10.1
19 pulmonary hypertension, primary, 1 10.1 NPPA NPPB
20 pericardial effusion 10.1 NPPA NPPB
21 heart valve disease 10.1 NPPA NPPB
22 chronic mountain sickness 10.1 NOS3 NPPB
23 toxic myocarditis 10.1 NOS3 NPPB
24 vasculogenic impotence 10.0 NOS3 NPPA
25 ischemic heart disease 10.0 NOS3 NPPB
26 aortic valve disease 2 10.0 NPPA NPPB
27 angina pectoris 10.0 NOS3 NPPB
28 stiff-person syndrome 10.0
29 craniosynostosis 10.0
30 hypothyroidism 10.0
31 acromegaly 10.0
32 renovascular hypertension 10.0 NOS3 NPPA
33 carotid artery occlusion 10.0 CA1 NOS3
34 mitral valve disease 10.0 NOS3 NPPA
35 hypoplastic left heart syndrome 10.0 LEP NPPA NPPB
36 muscle hypertrophy 9.9 LEP NPPA
37 mixed sleep apnea 9.9 CA1 SRC
38 diastolic heart failure 9.9 NOS3 NPPA NPPB
39 3-hydroxyacyl-coa dehydrogenase deficiency 9.9 LEP NOS3
40 pulmonary edema 9.9 NOS3 NPPA NPPB
41 coronary artery anomaly 9.9 NOS3 NPPA NPPB
42 arteries, anomalies of 9.9 LEP NOS3 NPPB
43 apnea, central sleep 9.9
44 multiple sclerosis 9.9
45 laryngomalacia 9.9
46 central hypoventilation syndrome, congenital 9.9
47 joubert syndrome 1 9.9
48 hydrocephalus, normal-pressure 9.9
49 vici syndrome 9.9
50 pituitary adenoma, prolactin-secreting 9.9

Graphical network of the top 20 diseases related to Central Sleep Apnea:



Diseases related to Central Sleep Apnea
Sources

Symptoms & Phenotypes for Central Sleep Apnea

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UMLS symptoms related to Central Sleep Apnea:


apnea

MGI Mouse Phenotypes related to Central Sleep Apnea:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.46 CHAT LEP NOS3 SRC
2 muscle MP:0005369 9.35 CHAT HSPB7 LEP NOS3 NPPA
3 respiratory system MP:0005388 9.02 CHAT HSPB7 LEP NOS3 SRC
Sources

Drugs & Therapeutics for Central Sleep Apnea

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Drugs for Central Sleep Apnea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 42)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zopiclone Approved Phase 4 43200-80-2 5735
2
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
3
Opium Approved, Illicit Phase 4 8008-60-4
4
Acetazolamide Approved, Vet_approved Phase 4 59-66-5 1986
5
Loperamide Approved Phase 4 53179-11-6 3955
6 Hypnotics and Sedatives Phase 4
7 Central Nervous System Depressants Phase 4,Phase 3,Not Applicable,Early Phase 1
8 Narcotics Phase 4,Phase 3,Not Applicable
9 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
10 Analgesics, Opioid Phase 4,Phase 3,Not Applicable
11 Analgesics Phase 4,Phase 3,Not Applicable
12 Antidiarrheals Phase 4
13 Antitussive Agents Phase 4
14 Carbonic Anhydrase Inhibitors Phase 4
15 Opium Poppy Phase 4
16 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
17 Respiratory System Agents Phase 4
18 Natriuretic Agents Phase 4
19 Anticonvulsants Phase 4
20 diuretics Phase 4,Not Applicable
21 Gastrointestinal Agents Phase 4
22
Morphine Approved, Investigational Phase 3 57-27-2 5288826
23
Ondansetron Approved Phase 3 99614-02-5 4595
24
Norepinephrine Approved Not Applicable 51-41-2 439260
25
Warfarin Approved Not Applicable 81-81-2 6691 54678486
26
Aspirin Approved, Vet_approved Not Applicable 50-78-2 2244
27
Spironolactone Approved Not Applicable 52-01-7, 1952-01-7 5833
28
Melatonin Approved, Nutraceutical, Vet_approved Not Applicable,Early Phase 1 73-31-4 896
29 Opiate Alkaloids
30 Vasoconstrictor Agents Not Applicable
31 Neurotransmitter Agents Not Applicable
32 Adrenergic Agents Not Applicable
33 Autonomic Agents Not Applicable
34 Adrenergic alpha-Agonists Not Applicable
35 Adrenergic Agonists Not Applicable
36 Sympathomimetics Not Applicable
37 Antioxidants Not Applicable,Early Phase 1
38 Protective Agents Not Applicable,Early Phase 1
39 Calamus Not Applicable
40 Adrenergic beta-Antagonists Not Applicable
41 Hydroxymethylglutaryl-CoA Reductase Inhibitors Not Applicable
42 Angiotensin-Converting Enzyme Inhibitors Not Applicable

Interventional clinical trials:

(show top 50) (show all 69)
# Name Status NCT ID Phase Drugs
1 Benefit of One Month Zopiclone Intake on Adaptative Servoventilation Compliance Unknown status NCT02820441 Phase 4 Zopiclone;Placebo
2 Cardiac Resynchronisation Therapy in Combination With Overdrive Pacing in the Treatment of Central Sleep Apnea in CHF Completed NCT00551499 Phase 4
3 Treatment of Predominant Central Sleep Apnoea by Adaptive Servo Ventilation in Patients With Heart Failure Completed NCT00733343 Phase 4
4 Substudy on the Mechanistic Plausibility of the Clinical Benefits of Adaptive Servo-ventilation Completed NCT01164592 Phase 4
5 Oxygen Versus Medical Air for Treatment of CSA in Prader Will Syndrome Recruiting NCT03031626 Phase 4
6 Effect of Adaptive Servo Ventilation (ASV) on Survival and Hospital Admissions in Heart Failure Recruiting NCT01128816 Phase 4
7 Effect of Acetazolamide on Central Sleep Apnea Related to Opium Consumption Enrolling by invitation NCT02371473 Phase 4 Acetazolamide-placebo;Placebo-acetazolamide
8 Nocturnal Oxygen Needs and Central Sleep Apnea in Patients With Chronic Heart Failure. Not yet recruiting NCT03254212 Phase 4
9 Bilevel Positive Pressure Ventilation (BIPAP)in Patients With Sleep Disorders Breathing (SDB)and Congestive Heart Failure (CHF):Comparison of Two Diagnostic Methods Unknown status NCT01501734 Phase 3
10 The Impact of Low Flow Nocturnal Oxygen Therapy on Hospital Admissions and Mortality in Patients With Heart Failure and Central Sleep Apnea Not yet recruiting NCT03745898 Phase 3 Oxygen
11 Morphine in Moderate Obstructive Sleep Apnoea Terminated NCT03127800 Phase 3 Morphine sulphate
12 Dynamic Carbon Dioxide (CO2) Administration for Sleep Apnoea Unknown status NCT01041924 Phase 2
13 Chronic Evaluation of Respicardia Therapy Completed NCT01124370 Phase 2
14 Outcome and Treatment of Complex Sleep Apnea Withdrawn NCT01137214 Phase 2
15 Effect of Adaptive Servoventilation on Cardiac Function in Chronic Heart Failure and Cheyne-Stokes Respiration Unknown status NCT01212705 Not Applicable
16 Interface Selection for Adaptive Servo Ventilation Unknown status NCT02919930 Not Applicable
17 Opiate Sleep Disordered Breathing Study Unknown status NCT00791674
18 Mechanisms of Pharyngeal Collapse in Sleep Apnea, Study D Unknown status NCT01733784 Not Applicable
19 Do Sleep and Circadian Rhythm Disturbances Impact the Cognitive and Behavioural Development of Children With Autism? Unknown status NCT02878499 Not Applicable
20 Effectiveness of Adaptive Servoventilation (ASV) in Patients With Central Sleep Apnea Due to Chronic Opioid Use Completed NCT01462084 Not Applicable
21 PAC-IC-SAS Pilot Study - Central Sleep Apneas Syndrome and Ventricular Function Completed NCT01741337 Not Applicable
22 The Effect of Adaptive Servo Ventilation and Oxygen Therapy in Central Sleep Apnea Patients Completed NCT01187823 Not Applicable
23 Leg Fluid Shift in Patients With Chronic Heart Failure and Obstructive or Central Sleep Apnea Completed NCT03092388 Not Applicable
24 BiPAP for Cardiomyopathy With Central Sleep Apnea Completed NCT00282789 Not Applicable
25 Effect of Heart Valve Replacement on Cheyne-Stokes Respiration Completed NCT01426776 Not Applicable
26 Different Loop Gain Phenotypes in Patients With Chronic Systolic Heart Failure and Periodic Breathing Completed NCT03532412
27 Respicardia, Inc. Pivotal Trial of the remedē System Completed NCT01816776 Not Applicable
28 Mechanisms of Action of Adaptive Servoventilation Completed NCT00976417
29 Bilevel Versus Servoventilation in Complex Sleep Apnea Completed NCT01609244 Not Applicable
30 Comparison of SomnaPatch With Polysomnography in Sleep Disordered Breathing Completed NCT02034175
31 Atrial Fibrillation Recurrence in Sleep Apnea Completed NCT00263757 Not Applicable
32 Comparison of CPAP With SOMNOventCR in Patients With Underlying Heart Disease, Combined OSA and CSR Completed NCT00811668 Not Applicable
33 Bipap Automatic Servo Ventilation (autoSV) Advanced in Central Apnea Patients Completed NCT01199042 Not Applicable
34 Nocturnal Oxygen Treatment in Heart Failure and Cheyne-Stokes Respiration Completed NCT00338078 Not Applicable
35 Pre-operative Polysomnography Assessment of Cardiac Surgery Inpatients Completed NCT00922168
36 A Multi-Center Study to Assess the Performance of Saturation Patterns. Completed NCT00775346
37 Adaptive Servo-Ventilation in "Real Life" Conditions : the OTRLASV Study Completed NCT02429986 Not Applicable
38 Effect of Intermittent Hemodialysis on Sleep Apnea Syndrome in End Stage Renal Disease Patients Completed NCT01860209 Not Applicable
39 Effect of Renal Transplantation on Obstructive Sleep Apnea in End Stage Renal Disease Patients (SASinTx) Completed NCT02020642 Not Applicable
40 Sleep-Disordered Breathing in Heart Failure - The SchlaHF-Registry Completed NCT01500759
41 Late-onset Congenital Central Hypoventilation Syndrome and the Mutation of Phox2B Gene Completed NCT01225679
42 Validation of the Peripheral Arterial Tone to Detect Sleep-disordered Breathing in Patients With Chronic Heart Failure Completed NCT02760680 Not Applicable
43 Belgian Central Sleep Apnea REgistry Recruiting NCT03621566
44 French Cohort Study of Chronic Heart Failure Patients With Central Sleep Apnoea Eligible for Adaptive Servo-Ventilation (PaceWave, AutoSet CS) Recruiting NCT01831128
45 Phrenic Nerve Stimulation for Treatment of Central Sleep Apnea Recruiting NCT03238937 Not Applicable
46 Sleep Apnea and CRT Upgrading Recruiting NCT01970423 Not Applicable
47 Quality of Sleep of Patients With Predominant Central Sleep Apnea Syndrome(SAS) Whose EF > 45% Treated by ASV Recruiting NCT02835638
48 Fluid Shift on Obstructive and Central Sleep Apnea Recruiting NCT02349997
49 ASV Effects on Myocardial Energetics and Sympathetic Nerve Function in Heart Failure and Sleep Apnea. Recruiting NCT02116140 Not Applicable
50 A Prospective Multicenter Registry of Patients With Sleep Disordered Breathing Treated With DreamStation BiPAP autoSV. Recruiting NCT03421704

Search NIH Clinical Center for Central Sleep Apnea

Cochrane evidence based reviews: sleep apnea, central

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Genetic Tests for Central Sleep Apnea

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Genetic tests related to Central Sleep Apnea:

# Genetic test Affiliating Genes
1 Central Sleep Apnea Syndrome 29
Sources

Anatomical Context for Central Sleep Apnea

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MalaCards organs/tissues related to Central Sleep Apnea:

41
Heart, Kidney, Brain, Testes, Eye, Tongue
Sources

Publications for Central Sleep Apnea

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Articles related to Central Sleep Apnea:

(show top 50) (show all 360)
# Title Authors Year
1
PRO: Persistent Central Sleep Apnea/Hunter-Cheyne-Stokes Breathing, Despite Best Guideline-Based Therapy of Heart Failure With Reduced Ejection Fraction, Is a Compensatory Mechanism and Should Not Be Suppressed. ( 29860966 )
2018
2
Transient Central Sleep Apnea Runs Triggered by Disorder of Arousal in a Child. ( 29852907 )
2018
3
Microstructural cerebral lesions are associated with the severity of central sleep apnea with Cheyne-Stokes-respiration in heart failure and are modified by PAP-therapy. ( 29102807 )
2018
4
Correlates and Consequences Central Sleep Apnea in a National Sample of U.S. Veterans. ( 29608761 )
2018
5
Central Sleep Apnea - a Rare Cause for Acute Respiratory Insufficiency in Children. Case Report. ( 29868143 )
2018
6
Cycle length identifies obstructive sleep apnea and central sleep apnea in heart failure with reduced ejection fraction. ( 29637409 )
2018
7
Transvenous phrenic nerve stimulation, a novel therapeutic approach for central sleep apnea. ( 29707357 )
2018
8
Natural history of treatment-emergent central sleep apnea on positive airway pressure: A systematic review. ( 29675059 )
2018
9
Sustained 12 Month Benefit of Phrenic Nerve Stimulation for Central Sleep Apnea. ( 29735217 )
2018
10
Increasing cerebral blood flow reduces the severity of central sleep apnea at high altitude. ( 29389246 )
2018
11
Adaptive Servoventilation as Treatment for Central Sleep Apnea Due to High-Altitude Periodic Breathing in Nonacclimatized Healthy Individuals. ( 29641294 )
2018
12
Adaptive servo-ventilation to treat central sleep apnea in heart failure with reduced ejection fraction: the BadA Oeynhausen prospective ASV registry. ( 29654439 )
2018
13
Central Sleep Apnea with Cheyne-Stokes Breathing in Heart Failure - From Research to Clinical Practice and Beyond. ( 29411336 )
2018
14
CON: Persistent Central Sleep Apnea/Hunter-Cheyne-Stokes Breathing, Despite Best Guideline-Based Therapy of Heart Failure With Reduced Ejection Fraction, Is Not a Compensatory Mechanism and Should Be Suppressed. ( 29852913 )
2018
15
Adaptive servo-ventilation and sleep quality in treatment emergent central sleep apnea and central sleep apnea in patients with heart disease and preserved ejection fraction. ( 29372314 )
2018
16
Primary central sleep apnea and anesthesia: a retrospective case series. ( 29717414 )
2018
17
Central Sleep Apnea Post Vagal Nerve Manipulation and Stimulation During Neck Tumor Resection: A Case Report. ( 29621011 )
2018
18
Obstructive Sleep Apnea in a Severely Obese Child With Combined Central Sleep Apnea and Sleep-Related Hypoventilation Disorder Caused by a Medullary Tumor. ( 29852906 )
2018
19
Chiari type 1 malformation associated with central sleep apnea after high dose growth hormone (GH) therapy in a 12-year-old boy: A case report. ( 29403156 )
2018
20
Temporal relationship between arousals and Cheyne-Stokes respiration with central sleep apnea in heart failure patients. ( 30015085 )
2018
21
Severe Positional Central Sleep Apnea in an Asymptomatic Adult With a PHOX2B Frameshift Mutation. ( 30092902 )
2018
22
Diagnosis, management and pathophysiology of central sleep apnea in children. ( 30170958 )
2018
23
Teaching NeuroImages: Sleep-related periodic breathing in acquired central sleep apnea. ( 30177538 )
2018
24
In patients with heart failure, the burden of central sleep apnea increases in the late sleep hours. ( 30325462 )
2018
25
Sleep Complaints and Sleep Architecture in Children With Idiopathic Central Sleep Apnea. ( 28212689 )
2017
26
Emergent central sleep apnea during CPAP therapy-clinical implications. ( 29268465 )
2017
27
Impairment of pulmonary diffusion correlates with hypoxemic burden in central sleep apnea heart failure patients. ( 28467884 )
2017
28
Focus on Functional Delayed Central Sleep Apnea Following Cervical Laminectomy. An Example of Respiratory Dysfunction in Restorative Neurosurgical Procedures. ( 28120077 )
2017
29
Long-Term Experience with First-Generation Implantable Neurostimulation Device in Central Sleep Apnea Treatment. ( 28211952 )
2017
30
Non-Mask-based Therapies for Central Sleep Apnea in Patients with Heart Failure. ( 28477779 )
2017
31
Monitoring of nocturnal central sleep apnea in Heart failure patients using noncontact respiratory differences. ( 29060172 )
2017
32
Evaluation of the central sleep apnea in asymptomatic children with Chiari 1 malformation: an open question. ( 28382434 )
2017
33
Central sleep apnea during continuous positive airway pressure therapy in obstructive sleep apnea patients: from the compliance to adaptation, maladaptation and reflexes. ( 29268457 )
2017
34
Central Sleep Apnea and Stiff Person Syndrome: A Case Report. ( 28358591 )
2017
35
Rapid-eye-movement sleep-predominant central sleep apnea relieved by positive airway pressure: a case report. ( 28483860 )
2017
36
Predominant obstructive or central sleep apnea in patients with atrial fibrillation: influence of characterizing apneas versus apneas and hypopneas. ( 28899542 )
2017
37
Trajectories of Emergent Central Sleep Apnea During CPAP Therapy. ( 28629918 )
2017
38
Central Sleep Apnea in Patients with Congestive Heart Failure. ( 28477776 )
2017
39
Obstructive and Central Sleep Apnea and the Risk of Incident Atrial Fibrillation in a Community Cohort of Men and Women. ( 28668820 )
2017
40
Low leptin concentration may identify heart failure patients with central sleep apnea. ( 28643476 )
2017
41
Relief for Central Sleep Apnea. ( 29164238 )
2017
42
Central sleep apnea: the problem of diagnosis. ( 28153696 )
2017
43
Central Sleep Apnea in Heart Failure: Sleeping With the Wrong Enemy? ( 28335842 )
2017
44
Respiratory drive in patients with chronic heart failure and central sleep apnea: Data from the Daunia Heart Failure Registry. ( 28065692 )
2017
45
Association between central sleep apnea and left ventricular structure: the Multi-Ethnic Study of Atherosclerosis. ( 28220556 )
2017
46
A Potential Novel Mechanism for Vagus Nerve Stimulator-Related Central Sleep Apnea. ( 28961186 )
2017
47
Association of Acromegaly and Central Sleep Apnea Syndrome. ( 30407161 )
2017
48
Safety and feasibility of chronic transvenous phrenic nerve stimulation for treatment of central sleep apnea in heart failure patients. ( 26072733 )
2017
49
Vertex Rolandic Spikes and Central Sleep Apnea inA aA Newborn. ( 27137362 )
2016
50
Ischemic Lesion Formation in Solitary Tract Nuclei During Central Sleep Apnea With Heart Failure. ( 26948864 )
2016
Sources

Variations for Central Sleep Apnea

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ClinVar genetic disease variations for Central Sleep Apnea:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CHAT NM_020549.4(CHAT): c.1061C> T (p.Thr354Met) single nucleotide variant Conflicting interpretations of pathogenicity rs769234940 GRCh37 Chromosome 10, 50835781: 50835781
2 CHAT NM_020549.4(CHAT): c.1061C> T (p.Thr354Met) single nucleotide variant Conflicting interpretations of pathogenicity rs769234940 GRCh38 Chromosome 10, 49627735: 49627735
3 CHAT NM_020549.4(CHAT): c.2081C> G (p.Ser694Cys) single nucleotide variant Pathogenic rs201439531 GRCh37 Chromosome 10, 50872926: 50872926
4 CHAT NM_020549.4(CHAT): c.2081C> G (p.Ser694Cys) single nucleotide variant Pathogenic rs201439531 GRCh38 Chromosome 10, 49664880: 49664880
Sources

Expression for Central Sleep Apnea

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Search GEO for disease gene expression data for Central Sleep Apnea.
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Pathways for Central Sleep Apnea

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Pathways related to Central Sleep Apnea according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Vascular smooth muscle contraction 37
Show member pathways
 12.29 NOS3 NPPB SRC
2
Prolactin Signaling Pathway 1 37
Show member pathways
 12 LEP NOS3 SRC
3
AGE/RAGE pathway 1
11.28 NOS3 SRC
4
Signaling events mediated by PTP1B 1
11.13 LEP SRC
5
Thromboxane A2 receptor signaling 1
11.06 NOS3 SRC
6
AMPK Enzyme Complex Pathway 64
Show member pathways
 11.03 LEP NOS3 SRC
7
Plasma membrane estrogen receptor signaling 1
10.74 NOS3 SRC
8
Differentiation of white and brown adipocyte 1
10.65 HSPB7 LEP
9
Angiogenesis (WikiPathways) 1
10.54 NOS3 SRC
10
Cardiomyocyte Differentiation through BMP Receptors 64
10.3 NPPA NPPB
Sources

GO Terms for Central Sleep Apnea

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Cellular components related to Central Sleep Apnea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 caveola GO:0005901 8.62 NOS3 SRC

Biological processes related to Central Sleep Apnea according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.69 LEP NPPA NPPB
2 response to insulin GO:0032868 9.49 LEP NPPA
3 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.48 LEP SRC
4 response to nutrient levels GO:0031667 9.46 LEP SRC
5 regulation of nitric-oxide synthase activity GO:0050999 9.43 LEP NOS3
6 positive regulation of insulin receptor signaling pathway GO:0046628 9.4 LEP SRC
7 cGMP biosynthetic process GO:0006182 9.37 NPPA NPPB
8 receptor guanylyl cyclase signaling pathway GO:0007168 9.32 NPPA NPPB
9 regulation of vascular permeability GO:0043114 9.26 NPPB SRC
10 ovulation from ovarian follicle GO:0001542 9.16 LEP NOS3
11 regulation of blood vessel size GO:0050880 9.13 NOS3 NPPA NPPB
12 regulation of blood pressure GO:0008217 8.92 LEP NOS3 NPPA NPPB

Molecular functions related to Central Sleep Apnea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.46 LEP NPPA NPPB SRC
2 scaffold protein binding GO:0097110 9.26 NOS3 SRC
3 hormone activity GO:0005179 9.13 LEP NPPA NPPB
4 hormone receptor binding GO:0051427 8.62 NPPA NPPB
Sources

Sources for Central Sleep Apnea

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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