MCID: CNT015
MIFTS: 50

Central Sleep Apnea

Categories: Mental diseases, Neuronal diseases, Respiratory diseases

Aliases & Classifications for Central Sleep Apnea

MalaCards integrated aliases for Central Sleep Apnea:

Name: Central Sleep Apnea 12 15
Central Sleep Apnea Syndrome 12 30 6 74
Sleep Apnea, Central 45 74
Central Sleep Apnea, Primary 74
Primary Central Sleep Apnea 12

Classifications:



External Ids:

Disease Ontology 12 DOID:9220
MeSH 45 D020182
NCIt 51 C116046

Summaries for Central Sleep Apnea

Disease Ontology : 12 A sleep apnea that is characterized by a malfunction of the basic neurological controls for breathing rate and the failure to give the signal to inhale, causing the individual to miss one or more cycles of breathing.

MalaCards based summary : Central Sleep Apnea, also known as central sleep apnea syndrome, is related to sleep apnea and systolic heart failure, and has symptoms including apnea An important gene associated with Central Sleep Apnea is CHAT (Choline O-Acetyltransferase), and among its related pathways/superpathways are Vascular smooth muscle contraction and Prolactin Signaling Pathway. The drugs Zopiclone and Olanzapine have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and eye, and related phenotypes are limbs/digits/tail and muscle

Wikipedia : 77 Central sleep apnea (CSA) or central sleep apnea syndrome (CSAS) is a sleep-related disorder in which... more...

Related Diseases for Central Sleep Apnea

Diseases in the Sleep Apnea family:

Central Sleep Apnea

Diseases related to Central Sleep Apnea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 81)
# Related Disease Score Top Affiliating Genes
1 sleep apnea 32.4 LEP NOS3 NPPB
2 systolic heart failure 30.5 HSPB7 NPPB
3 mitral valve insufficiency 30.1 NPPA NPPB
4 heart valve disease 30.0 NPPA NPPB
5 pulmonary hypertension 29.9 NOS3 NPPA NPPB
6 kidney disease 29.9 NOS3 NPPA NPPB
7 chronic kidney failure 29.6 LEP NOS3 NPPA NPPB
8 dilated cardiomyopathy 29.6 HSPB7 NOS3 NPPA NPPB
9 idiopathic alveolar hypoventilation syndrome 11.9
10 chiari malformation 11.6
11 chiari malformation type i 11.2
12 chiari malformation type ii 11.2
13 rere-related disorders 10.9
14 congestive heart failure 10.6
15 atrial fibrillation 10.2
16 anterolateral myocardial infarction 10.2 NPPA NPPB
17 syndrome of inappropriate antidiuretic hormone 10.2 NPPA NPPB
18 mitral valve stenosis 10.2 NPPA NPPB
19 heart disease 10.2
20 idiopathic edema 10.2 NPPA NPPB
21 syncope 10.2 NPPA NPPB
22 pulmonary hypertension, primary, 1 10.1 NPPA NPPB
23 pericardial effusion 10.1 NPPA NPPB
24 apnea, obstructive sleep 10.1
25 chronic mountain sickness 10.1 NOS3 NPPB
26 toxic myocarditis 10.1 NOS3 NPPB
27 vasculogenic impotence 10.1 NOS3 NPPA
28 aortic valve disease 2 10.1 NPPA NPPB
29 ischemic heart disease 10.1 NOS3 NPPB
30 stiff-person syndrome 10.0
31 craniosynostosis 10.0
32 hypothyroidism 10.0
33 acromegaly 10.0
34 angina pectoris 10.0 NOS3 NPPB
35 renovascular hypertension 10.0 NOS3 NPPA
36 carotid artery occlusion 10.0 CA1 NOS3
37 mitral valve disease 10.0 NOS3 NPPA
38 hypoplastic left heart syndrome 9.9 LEP NPPA NPPB
39 muscle hypertrophy 9.9 LEP NPPA
40 mixed sleep apnea 9.9 CA1 SRC
41 central serous chorioretinopathy 9.9
42 apnea, central sleep 9.9
43 multiple sclerosis 9.9
44 laryngomalacia 9.9
45 digeorge syndrome 9.9
46 central hypoventilation syndrome, congenital 9.9
47 joubert syndrome 1 9.9
48 hydrocephalus, normal-pressure 9.9
49 vici syndrome 9.9
50 sudden infant death syndrome 9.9

Graphical network of the top 20 diseases related to Central Sleep Apnea:



Diseases related to Central Sleep Apnea

Symptoms & Phenotypes for Central Sleep Apnea

UMLS symptoms related to Central Sleep Apnea:


apnea

MGI Mouse Phenotypes related to Central Sleep Apnea:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 limbs/digits/tail MP:0005371 9.46 CHAT LEP NOS3 SRC
2 muscle MP:0005369 9.35 CHAT HSPB7 LEP NOS3 NPPA
3 respiratory system MP:0005388 9.02 CHAT HSPB7 LEP NOS3 SRC

Drugs & Therapeutics for Central Sleep Apnea

Drugs for Central Sleep Apnea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 108)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Zopiclone Approved Phase 4 43200-80-2 5735
2
Olanzapine Approved, Investigational Phase 4 132539-06-1 4585
3
Desflurane Approved Phase 4 57041-67-5 42113
4
Fentanyl Approved, Illicit, Investigational, Vet_approved Phase 4 437-38-7 3345
5
Remifentanil Approved Phase 4 132875-61-7 60815
6
Sevoflurane Approved, Vet_approved Phase 4 28523-86-6 5206
7
tannic acid Approved Phase 4 1401-55-4
8
Benzocaine Approved, Investigational Phase 4 1994-09-7, 94-09-7 2337
9
Trazodone Approved, Investigational Phase 4 19794-93-5 5533
10
Acetazolamide Approved, Vet_approved Phase 4,Phase 3 59-66-5 1986
11
Finasteride Approved Phase 4 98319-26-7 57363
12
Testosterone Approved, Experimental, Investigational Phase 4 58-22-0, 481-30-1 10204 6013
13
Opium Approved, Illicit Phase 4 8008-60-4
14
Loperamide Approved Phase 4 53179-11-6 3955
15
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
16 Central Nervous System Depressants Phase 4,Phase 3,Not Applicable,Early Phase 1
17 Hypnotics and Sedatives Phase 4,Phase 3
18 Peripheral Nervous System Agents Phase 4,Phase 3,Not Applicable
19 Narcotics Phase 4,Phase 3,Not Applicable
20 Analgesics, Opioid Phase 4,Phase 3,Not Applicable
21 Analgesics Phase 4,Phase 3,Not Applicable
22 Tranquilizing Agents Phase 4,Phase 3
23 Gastrointestinal Agents Phase 4
24 Antipsychotic Agents Phase 4
25 Antiemetics Phase 4
26 Neurotransmitter Uptake Inhibitors Phase 4,Phase 3
27 Autonomic Agents Phase 4,Not Applicable
28 Psychotropic Drugs Phase 4,Phase 3
29 Neurotransmitter Agents Phase 4,Phase 3,Not Applicable
30 Serotonin Agents Phase 4,Phase 3
31 Serotonin Uptake Inhibitors Phase 4,Phase 3
32 Anesthetics Phase 4,Phase 3,Not Applicable
33 Anesthetics, Inhalation Phase 4
34 Anesthetics, Intravenous Phase 4,Phase 3
35 Adjuvants, Anesthesia Phase 4
36 Platelet Aggregation Inhibitors Phase 4
37 Anesthetics, General Phase 4,Phase 3
38 Antidepressive Agents Phase 4,Phase 3
39 Antidepressive Agents, Second-Generation Phase 4,Phase 3
40 Hormones Phase 4,Phase 2,Phase 3
41 Hormone Antagonists Phase 4,Phase 2,Phase 3
42 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 4,Phase 2,Phase 3
43 Anti-Anxiety Agents Phase 4,Phase 3
44 Steroid Synthesis Inhibitors Phase 4
45 Carbonic Anhydrase Inhibitors Phase 4,Phase 3
46 Natriuretic Agents Phase 4,Phase 3
47 5-alpha Reductase Inhibitors Phase 4
48 Anticonvulsants Phase 4,Phase 3
49 diuretics Phase 4,Phase 3,Not Applicable
50 Antidiarrheals Phase 4

Interventional clinical trials:

(show top 50) (show all 125)
# Name Status NCT ID Phase Drugs
1 Benefit of One Month Zopiclone Intake on Adaptative Servoventilation Compliance Unknown status NCT02820441 Phase 4 Zopiclone;Placebo
2 Cardiac Resynchronisation Therapy in Combination With Overdrive Pacing in the Treatment of Central Sleep Apnea in CHF Completed NCT00551499 Phase 4
3 Treatment of Predominant Central Sleep Apnoea by Adaptive Servo Ventilation in Patients With Heart Failure Completed NCT00733343 Phase 4
4 Substudy on the Mechanistic Plausibility of the Clinical Benefits of Adaptive Servo-ventilation Completed NCT01164592 Phase 4
5 An Investigation of the Sleep Architecture and Consequent Cognitive Changes in Olanzapine-Treated Depressed Patients Completed NCT00520507 Phase 4 Olanzapine;Placebo
6 Short Life Agents in Balanced Anesthesia on Obstructive Sleep Apnea Syndrome Completed NCT02717780 Phase 4 Fentanyl and sevoflurane;Remifentanil and desflurane
7 Nocturnal Oxygen Needs and Central Sleep Apnea in Patients With Chronic Heart Failure. Recruiting NCT03254212 Phase 4
8 Oxygen Versus Medical Air for Treatment of CSA in Prader Will Syndrome Recruiting NCT03031626 Phase 4
9 Effect of Adaptive Servo Ventilation (ASV) on Survival and Hospital Admissions in Heart Failure Recruiting NCT01128816 Phase 4
10 Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury Recruiting NCT02922894 Phase 4 Trazodone;Placebo
11 Sleep Apnea in Elderly Recruiting NCT02703220 Phase 4 Acetazolamide;Finasteride
12 Effect of Acetazolamide on Central Sleep Apnea Related to Opium Consumption Enrolling by invitation NCT02371473 Phase 4 Acetazolamide-placebo;Placebo-acetazolamide
13 Effect of Servo-Ventilation on CO2 Regulation and Heart Rate Variability Not yet recruiting NCT03890939 Phase 4
14 Bilevel Positive Pressure Ventilation (BIPAP)in Patients With Sleep Disorders Breathing (SDB)and Congestive Heart Failure (CHF):Comparison of Two Diagnostic Methods Unknown status NCT01501734 Phase 3
15 Assessment of Desogestrel in Ondine Syndrome Completed NCT01243697 Phase 2, Phase 3 desogestrel
16 Efficacy of Fluoxetine Against Seizure-induced Central Apneas Completed NCT02569970 Phase 3 fluoxetine 20 mg;placebo 20 mg
17 Ketofol vs Propofol for Emergency Department Procedural Sedation and Analgesia Completed NCT01211158 Phase 3 Ketofol;Propofol alone
18 Caffeine for Apnea of Prematurity-Sleep (CAP-S) Study Completed NCT01020357 Phase 3 Caffeine citrate injection;placebo
19 The Impact of Low Flow Nocturnal Oxygen Therapy on Hospital Admissions and Mortality in Patients With Heart Failure and Central Sleep Apnea Not yet recruiting NCT03745898 Phase 3 Oxygen
20 Morphine in Moderate Obstructive Sleep Apnoea Terminated NCT03127800 Phase 3 Morphine sulphate
21 Buspirone as a Potential Treatment for Recurrent Central Apnea Terminated NCT00746954 Phase 3 Acetazolamide;Buspirone
22 Dynamic Carbon Dioxide (CO2) Administration for Sleep Apnoea Unknown status NCT01041924 Phase 2
23 Chronic Evaluation of Respicardia Therapy Completed NCT01124370 Phase 2
24 Stroke and CPAP Outcome Study 2 Completed NCT02809430 Phase 2
25 Safety of Ramelteon in Subjects With Mild to Moderate Obstructive Sleep Apnea Completed NCT00672061 Phase 2 Ramelteon or Placebo
26 Effect of Fenofibrate on Sleep Apnea Syndrome Terminated NCT00816829 Phase 2 Placebo;Fenofibrate
27 Outcome and Treatment of Complex Sleep Apnea Withdrawn NCT01137214 Phase 2
28 Effect of Adaptive Servoventilation on Cardiac Function in Chronic Heart Failure and Cheyne-Stokes Respiration Unknown status NCT01212705 Not Applicable
29 Interface Selection for Adaptive Servo Ventilation Unknown status NCT02919930 Not Applicable
30 Opiate Sleep Disordered Breathing Study Unknown status NCT00791674
31 Mechanisms of Pharyngeal Collapse in Sleep Apnea, Study D Unknown status NCT01733784 Not Applicable
32 Pathophysiology of Central Apnoeas in Stroke Patients Unknown status NCT01723189
33 PHOX2B Mutation-Confirmed Congenital Central Hypoventilation Syndrome in A Chinese Family: Presentations From Newborn to Adulthood Unknown status NCT00652964
34 Intrinsic Periodic Pattern of Breathing Unknown status NCT02201875
35 Normal Polysomnography Values in Healthy Children and Adolescents in China Unknown status NCT02761902
36 Effectiveness of Adaptive Servoventilation (ASV) in Patients With Central Sleep Apnea Due to Chronic Opioid Use Completed NCT01462084 Not Applicable
37 PAC-IC-SAS Pilot Study - Central Sleep Apneas Syndrome and Ventricular Function Completed NCT01741337 Not Applicable
38 The Effect of Adaptive Servo Ventilation and Oxygen Therapy in Central Sleep Apnea Patients Completed NCT01187823 Not Applicable
39 Leg Fluid Shift in Patients With Chronic Heart Failure and Obstructive or Central Sleep Apnea Completed NCT03092388 Not Applicable
40 Fluid Shift on Obstructive and Central Sleep Apnea Completed NCT02349997
41 BiPAP for Cardiomyopathy With Central Sleep Apnea Completed NCT00282789 Not Applicable
42 Effect of Heart Valve Replacement on Cheyne-Stokes Respiration Completed NCT01426776 Not Applicable
43 Different Loop Gain Phenotypes in Patients With Chronic Systolic Heart Failure and Periodic Breathing Completed NCT03532412
44 Respicardia, Inc. Pivotal Trial of the remedē System Completed NCT01816776 Not Applicable
45 Mechanisms of Action of Adaptive Servoventilation Completed NCT00976417
46 Bilevel Versus Servoventilation in Complex Sleep Apnea Completed NCT01609244 Not Applicable
47 Comparison of SomnaPatch With Polysomnography in Sleep Disordered Breathing Completed NCT02034175 Not Applicable
48 Atrial Fibrillation Recurrence in Sleep Apnea Completed NCT00263757 Not Applicable
49 Servo-Ventilation In-lab PSG Evaluation Completed NCT02808338 Not Applicable
50 Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude. Completed NCT03368352 Early Phase 1

Search NIH Clinical Center for Central Sleep Apnea

Cochrane evidence based reviews: sleep apnea, central

Genetic Tests for Central Sleep Apnea

Genetic tests related to Central Sleep Apnea:

# Genetic test Affiliating Genes
1 Central Sleep Apnea Syndrome 30

Anatomical Context for Central Sleep Apnea

MalaCards organs/tissues related to Central Sleep Apnea:

42
Heart, Kidney, Eye, Spinal Cord, Tongue, Brain, Testes

Publications for Central Sleep Apnea

Articles related to Central Sleep Apnea:

(show top 50) (show all 375)
# Title Authors Year
1
In patients with heart failure the burden of central sleep apnea increases in the late sleep hours. ( 30325462 )
2019
2
Effects of Adaptive Servoventilation Therapy for Central Sleep Apnea on Health Care Utilization and Mortality: A Population-Based Study. ( 30621843 )
2019
3
Polysomnographic Analysis of a Pediatric Case of Baclofen-Induced Central Sleep Apnea. ( 30736882 )
2019
4
How to Implant a Phrenic Nerve Stimulator for Treatment of Central Sleep Apnea? ( 30834611 )
2019
5
Central Sleep Apnea With Sodium Oxybate in a Pediatric Patient. ( 30853045 )
2019
6
Tongue Stabilizing Device-Emergent Central Sleep Apnea: A Case Report. ( 30952219 )
2019
7
Comparative Evaluation of Therapeutic Approaches to Central Sleep Apnea. ( 30993083 )
2019
8
Diagnosis and management of central sleep apnea syndrome. ( 31014146 )
2019
9
Heterogeneity of Periodic Limb Movements Associated With Central Sleep Apnea in Heart Failure Patients. ( 31029412 )
2019
10
Primary central sleep apnea and anesthesia: a retrospective case series. ( 29717414 )
2018
11
Sustained 12 Month Benefit of Phrenic Nerve Stimulation for Central Sleep Apnea. ( 29735217 )
2018
12
Ticagrelor and Central Sleep Apnea. ( 29773166 )
2018
13
Obstructive Sleep Apnea in a Severely Obese Child With Combined Central Sleep Apnea and Sleep-Related Hypoventilation Disorder Caused by a Medullary Tumor. ( 29852906 )
2018
14
Transient Central Sleep Apnea Runs Triggered by Disorder of Arousal in a Child. ( 29852907 )
2018
15
CON: Persistent Central Sleep Apnea/Hunter-Cheyne-Stokes Breathing, Despite Best Guideline-Based Therapy of Heart Failure With Reduced Ejection Fraction, Is Not a Compensatory Mechanism and Should Be Suppressed. ( 29852913 )
2018
16
PRO: Persistent Central Sleep Apnea/Hunter-Cheyne-Stokes Breathing, Despite Best Guideline-Based Therapy of Heart Failure With Reduced Ejection Fraction, Is a Compensatory Mechanism and Should Not Be Suppressed. ( 29860966 )
2018
17
Central Sleep Apnea - a Rare Cause for Acute Respiratory Insufficiency in Children. Case Report. ( 29868143 )
2018
18
Temporal relationship between arousals and Cheyne-Stokes respiration with central sleep apnea in heart failure patients. ( 30015085 )
2018
19
Severe Positional Central Sleep Apnea in an Asymptomatic Adult With a PHOX2B Frameshift Mutation. ( 30092902 )
2018
20
Diagnosis, management and pathophysiology of central sleep apnea in children. ( 30170958 )
2018
21
Teaching NeuroImages: Sleep-related periodic breathing in acquired central sleep apnea. ( 30177538 )
2018
22
A case of positional central sleep apnea due to compression of the left vertebral artery on brainstem. ( 30746037 )
2018
23
Comparison of Therapeutic Approaches to Addicted Patients with Central Sleep Apnea. ( 30915131 )
2018
24
Low leptin concentration may identify heart failure patients with central sleep apnea. ( 28643476 )
2018
25
Microstructural cerebral lesions are associated with the severity of central sleep apnea with Cheyne-Stokes-respiration in heart failure and are modified by PAP-therapy. ( 29102807 )
2018
26
Adaptive servo-ventilation and sleep quality in treatment emergent central sleep apnea and central sleep apnea in patients with heart disease and preserved ejection fraction. ( 29372314 )
2018
27
Increasing cerebral blood flow reduces the severity of central sleep apnea at high altitude. ( 29389246 )
2018
28
Chiari type 1 malformation associated with central sleep apnea after high dose growth hormone (GH) therapy in a 12-year-old boy: A case report. ( 29403156 )
2018
29
Central Sleep Apnea with Cheyne-Stokes Breathing in Heart Failure - From Research to Clinical Practice and Beyond. ( 29411336 )
2018
30
Correlates and consequences of central sleep apnea in a national sample of US veterans. ( 29608761 )
2018
31
Central Sleep Apnea Post Vagal Nerve Manipulation and Stimulation During Neck Tumor Resection: A Case Report. ( 29621011 )
2018
32
Cycle length identifies obstructive sleep apnea and central sleep apnea in heart failure with reduced ejection fraction. ( 29637409 )
2018
33
Adaptive Servoventilation as Treatment for Central Sleep Apnea Due to High-Altitude Periodic Breathing in Nonacclimatized Healthy Individuals. ( 29641294 )
2018
34
Adaptive servo-ventilation to treat central sleep apnea in heart failure with reduced ejection fraction: the Bad Oeynhausen prospective ASV registry. ( 29654439 )
2018
35
Natural history of treatment-emergent central sleep apnea on positive airway pressure: A systematic review. ( 29675059 )
2018
36
Transvenous phrenic nerve stimulation, a novel therapeutic approach for central sleep apnea. ( 29707357 )
2018
37
Association of Acromegaly and Central Sleep Apnea Syndrome. ( 30407161 )
2017
38
Safety and feasibility of chronic transvenous phrenic nerve stimulation for treatment of central sleep apnea in heart failure patients. ( 26072733 )
2017
39
Sympathetic nervous system, systolic heart failure, and central sleep apnea: Are we about to find the missing link? ( 27457530 )
2017
40
Prognostic Importance of Novel Oxygen Desaturation Metrics in Patients With Heart Failure and Central Sleep Apnea. ( 27615064 )
2017
41
Central sleep apnea in multiple sclerosis: a pilot study. ( 27975178 )
2017
42
Respiratory drive in patients with chronic heart failure and central sleep apnea: Data from the Daunia Heart Failure Registry. ( 28065692 )
2017
43
Focus on Functional Delayed Central Sleep Apnea Following Cervical Laminectomy. An Example of Respiratory Dysfunction in Restorative Neurosurgical Procedures. ( 28120077 )
2017
44
Central sleep apnea: the problem of diagnosis. ( 28153696 )
2017
45
Long-Term Experience with First-Generation Implantable Neurostimulation Device in Central Sleep Apnea Treatment. ( 28211952 )
2017
46
Sleep Complaints and Sleep Architecture in Children With Idiopathic Central Sleep Apnea. ( 28212689 )
2017
47
Association between central sleep apnea and left ventricular structure: the Multi-Ethnic Study of Atherosclerosis. ( 28220556 )
2017
48
Central Sleep Apnea in Heart Failure: Sleeping With the Wrong Enemy? ( 28335842 )
2017
49
Central Sleep Apnea and Stiff Person Syndrome: A Case Report. ( 28358591 )
2017
50
Evaluation of the central sleep apnea in asymptomatic children with Chiari 1 malformation: an open question. ( 28382434 )
2017

Variations for Central Sleep Apnea

ClinVar genetic disease variations for Central Sleep Apnea:

6
# Gene Variation Type Significance SNP ID Assembly Location
1 CHAT NM_020549.4(CHAT): c.1061C> T (p.Thr354Met) single nucleotide variant Conflicting interpretations of pathogenicity rs769234940 GRCh37 Chromosome 10, 50835781: 50835781
2 CHAT NM_020549.4(CHAT): c.1061C> T (p.Thr354Met) single nucleotide variant Conflicting interpretations of pathogenicity rs769234940 GRCh38 Chromosome 10, 49627735: 49627735
3 CHAT NM_020549.4(CHAT): c.2081C> G (p.Ser694Cys) single nucleotide variant Pathogenic rs201439531 GRCh37 Chromosome 10, 50872926: 50872926
4 CHAT NM_020549.4(CHAT): c.2081C> G (p.Ser694Cys) single nucleotide variant Pathogenic rs201439531 GRCh38 Chromosome 10, 49664880: 49664880

Expression for Central Sleep Apnea

Search GEO for disease gene expression data for Central Sleep Apnea.

Pathways for Central Sleep Apnea

GO Terms for Central Sleep Apnea

Cellular components related to Central Sleep Apnea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 caveola GO:0005901 8.62 NOS3 SRC

Biological processes related to Central Sleep Apnea according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 regulation of signaling receptor activity GO:0010469 9.69 LEP NPPA NPPB
2 response to insulin GO:0032868 9.49 LEP NPPA
3 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.48 LEP SRC
4 response to nutrient levels GO:0031667 9.46 LEP SRC
5 regulation of nitric-oxide synthase activity GO:0050999 9.43 LEP NOS3
6 positive regulation of insulin receptor signaling pathway GO:0046628 9.4 LEP SRC
7 cGMP biosynthetic process GO:0006182 9.37 NPPA NPPB
8 receptor guanylyl cyclase signaling pathway GO:0007168 9.32 NPPA NPPB
9 regulation of vascular permeability GO:0043114 9.26 NPPB SRC
10 ovulation from ovarian follicle GO:0001542 9.16 LEP NOS3
11 regulation of blood vessel size GO:0050880 9.13 NOS3 NPPA NPPB
12 regulation of blood pressure GO:0008217 8.92 LEP NOS3 NPPA NPPB

Molecular functions related to Central Sleep Apnea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.46 LEP NPPA NPPB SRC
2 scaffold protein binding GO:0097110 9.26 NOS3 SRC
3 hormone activity GO:0005179 9.13 LEP NPPA NPPB
4 hormone receptor binding GO:0051427 8.62 NPPA NPPB

Sources for Central Sleep Apnea

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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