Central Sleep Apnea

Categories: Mental diseases, Neuronal diseases, Respiratory diseases
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Aliases & Classifications for Central Sleep Apnea

MalaCards integrated aliases for Central Sleep Apnea:

Name: Central Sleep Apnea 11 14 75
Central Sleep Apnea Syndrome 11 71
Sleep Apnea, Central 43 71
Central Sleep Apnoea Due to Substances Including Medications 33
Csas - [central Sleep Apnoea Syndrome] 33
Central Sleep Apnoea Syndrome 33
Central Sleep Apnea, Primary 71
Csa - [central Sleep Apnoea] 33
Primary Central Sleep Apnea 11


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Disease Ontology 11 DOID:9220
MeSH 43 D020182
NCIt 49 C116046
UMLS 71 C0520680 C0751762 C3887547

Summaries for Central Sleep Apnea

Disease Ontology: 11 A sleep apnea that is characterized by a malfunction of the basic neurological controls for breathing rate and the failure to give the signal to inhale, causing the individual to miss one or more cycles of breathing.

MalaCards based summary: Central Sleep Apnea, also known as central sleep apnea syndrome, is related to sleep apnea and apnea, obstructive sleep, and has symptoms including apnea An important gene associated with Central Sleep Apnea is PHOX2B (Paired Like Homeobox 2B). The drugs Opium and Zolpidem have been mentioned in the context of this disorder. Affiliated tissues include heart, spinal cord and medulla oblongata, and related phenotypes are nervous system and cardiovascular system

Wikipedia: 75 Central sleep apnea (CSA) or central sleep apnea syndrome (CSAS) is a sleep-related disorder in which... more...

Related Diseases for Central Sleep Apnea

Diseases in the Sleep Apnea family:

Central Sleep Apnea

Diseases related to Central Sleep Apnea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 340)
# Related Disease Score Top Affiliating Genes
1 sleep apnea 31.6 REN PHOX2B NPPB LEP KCNK3 HCRT
2 apnea, obstructive sleep 31.0 REN NPPB LEP IGLON5 HCRT CRP
3 systolic heart failure 30.9 REN NPPB CRP ACE
4 respiratory failure 30.8 REN NPPB CRP ACE
5 atrioventricular block 30.5 NPPB CRP ACE
6 mitral valve insufficiency 30.5 REN NPPB CRP ACE
7 heart valve disease 30.5 REN NPPB CRP ACE
8 pulmonary hypertension 30.4 REN NPPB KCNK3 CRP ACE
9 stroke, ischemic 30.4 REN NPPB CRP ACE
10 sleep disorder 30.4 REN LEP IGLON5 HCRT CRP ACE
11 pulmonary edema 30.3 REN NPPB CRP ACE
12 chronic kidney disease 30.3 REN NPPB LEP CRP ACE
13 diabetes mellitus, ketosis-prone 30.3 REN CRP ACE
14 carotid stenosis 30.2 REN CRP ACE
15 pulmonary embolism 30.2 NPPB CRP ACE
16 cardiac arrest 30.2 NPPB CRP ACE
17 polycythemia 30.1 REN CRP ACE
18 left bundle branch hemiblock 30.1 REN NPPB CRP ACE
19 hypertensive heart disease 30.1 REN NPPB CRP ACE
20 intermediate coronary syndrome 30.1 REN NPPB CRP ACE
21 third-degree atrioventricular block 30.1 REN NPPB CRP ACE
22 transient cerebral ischemia 30.1 REN NPPB CRP ACE
23 covid-19 30.1 REN NPPB CRP ACE
24 aortic valve disease 2 30.1 REN NPPB CRP ACE
25 acute myocardial infarction 30.1 REN NPPB CRP ACE
26 congenital central hypoventilation syndrome 30.1 PHOX2B LBX1 KCNK9 KCNK3 HCRT GPR4
27 adult syndrome 30.0 REN LEP CRP
28 hypothyroidism 29.9 REN NPPB LEP CRP ACE
29 anxiety 29.6 PALS1 LEP HCRT CRP ACE
30 migraine with or without aura 1 29.4 REN LEP KCNK9 KCNK3 HCRT CRP
31 nervous system disease 29.1 REN PHOX2B NALCN LEP HCRT CRP
32 idiopathic alveolar hypoventilation syndrome 11.5
33 chiari malformation 11.2
34 chiari malformation type i 11.2
35 chiari malformation type ii 11.2
36 potocki-lupski syndrome 11.2
37 heart disease 10.9
38 congestive heart failure 10.8
39 atrial fibrillation 10.5
40 mixed sleep apnea 10.5
41 anterolateral myocardial infarction 10.4 NPPB ACE
42 hypoaldosteronism 10.3 REN ACE
43 renal artery obstruction 10.3 REN ACE
44 pyeloureteritis cystica 10.3 REN CRP
45 polycystic kidney disease 4 10.3 REN NPPB
46 toxic myocarditis 10.3 NPPB ACE
47 orthostatic proteinuria 10.3 REN ACE
48 inferior myocardial infarction 10.3 NPPB ACE
49 hypertension, diastolic 10.3 REN ACE
50 apnea, central sleep 10.3

Graphical network of the top 20 diseases related to Central Sleep Apnea:

Diseases related to Central Sleep Apnea

Symptoms & Phenotypes for Central Sleep Apnea

UMLS symptoms related to Central Sleep Apnea:


MGI Mouse Phenotypes related to Central Sleep Apnea:

# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.9 GPR4 HCRT KCNK3 KCNK9 LBX1 LEP
2 cardiovascular system MP:0005385 9.7 ACE CRP GPR4 HCRT KCNK3 KCNK9
3 respiratory system MP:0005388 9.17 GPR4 HCRT KCNK3 KCNK9 LEP NALCN

Drugs & Therapeutics for Central Sleep Apnea

Drugs for Central Sleep Apnea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 43)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Opium Approved, Illicit Phase 4 8008-60-4
Zolpidem Approved Phase 4 82626-48-0 5732
Diphenhydramine Approved, Investigational Phase 4 147-24-0, 58-73-1 3100
Promethazine Approved, Investigational Phase 4 60-87-7 4927
Ethanol Approved Phase 4 64-17-5 702
Naltrexone Approved, Investigational, Vet_approved Phase 4 16590-41-3 5360515
Zopiclone Approved Phase 4 43200-80-2 5735
8 Opium Poppy Phase 4
9 GABA Agonists Phase 4
10 Narcotics Phase 4
11 Narcotic Antagonists Phase 4
12 Hypnotics and Sedatives Phase 4
Fluoxetine Approved, Vet_approved Phase 3 54910-89-3 3386
Desogestrel Approved Phase 2, Phase 3 54024-22-5 40973
Buspirone Approved, Investigational Phase 3 36505-84-7 2477
Acetazolamide Approved, Vet_approved Phase 3 59-66-5, 1424-27-7 1986
17 Antidepressive Agents Phase 3
18 Serotonin Uptake Inhibitors Phase 3
19 Cytochrome P-450 Enzyme Inhibitors Phase 3
20 Hormones Phase 2, Phase 3
21 Hormone Antagonists Phase 2, Phase 3
22 Contraceptives, Oral, Hormonal Phase 2, Phase 3
23 Contraceptives, Oral Phase 2, Phase 3
24 Contraceptive Agents Phase 2, Phase 3
25 Progestins Phase 2, Phase 3
26 Carbonic Anhydrase Inhibitors Phase 3
27 Neurotransmitter Agents Phase 3
28 Anti-Anxiety Agents Phase 3
29 Psychotropic Drugs Phase 3
30 Anticonvulsants Phase 3
31 Serotonin Receptor Agonists Phase 3
32 diuretics Phase 3
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202
Ticagrelor Approved 274693-27-5 9871419
Estradiol Approved, Investigational, Vet_approved 50-28-2 5757
Ethinylestradiol Approved 57-63-6 5991
Polyestradiol phosphate Approved 28014-46-2
Metronidazole Approved 443-48-1, 69198-10-3 4173
Norepinephrine Approved 51-41-2 439260
40 Estradiol 3-benzoate
41 Estradiol 17 beta-cypionate
42 Contraceptives, Oral, Combined
43 Analgesics, Opioid

Interventional clinical trials:

(show top 50) (show all 74)
# Name Status NCT ID Phase Drugs
1 Effect of Acetazolamide on Central Sleep Apnea Related to Opium Consumption Unknown status NCT02371473 Phase 4 Acetazolamide-placebo;Placebo-acetazolamide
2 Cardiac Resynchronisation Therapy in Combination With Overdrive Pacing in the Treatment of Central Sleep Apnea in CHF Completed NCT00551499 Phase 4
3 Central Sleep Apnea: Physiologic Mechanisms to Inform Treatment Recruiting NCT04118387 Phase 4 Acetazolamide + supplemental oxygen + PAP therapy;Zolpidem + PAP therapy;Buspirone + PAP therapy
4 Comparison of Therapeutic Oxygen Versus Medical Air for the Treatment of Central Sleep Apnea in Infants and Children With Prader Willi Syndrome: A Proof of Concept Study Recruiting NCT03031626 Phase 4
5 Evaluation of Nocturnal Oxygen Needs in the Treatment of Central Sleep Apnea in Patients With Chronic Heart Failure. Recruiting NCT03254212 Phase 4
6 Effects of Naltrexone on Nocturnal Breathing Patterns at Altitude Recruiting NCT05037032 Phase 4 Naltrexone Pill;Placebo
7 Adaptative Servoventilation Compliance in Left Ventricular Dysfunction Patients With Central Sleep Apnea: Benefit of One Month Hypnotic (Zopiclone) Versus Placebo Terminated NCT02820441 Phase 4 Zopiclone;Placebo
8 Efficacy of Fluoxetine Against Seizure-induced Central Apneas : a Randomized Placebo-controled Double-blind Trial. Completed NCT02569970 Phase 3 fluoxetine 20 mg;placebo 20 mg
9 Assessment of Desogestrel for a Pharmacological Recovery of Ventilatory Activity in Congenital Central Hypoventilation Syndrome - Ondine Syndrome Completed NCT01243697 Phase 2, Phase 3 desogestrel
10 The Impact of Low Flow Nocturnal Oxygen Therapy on Hospital Admissions and Mortality in Patients With Heart Failure and Central Sleep Apnea (LOFT-HF) Terminated NCT03745898 Phase 3 Oxygen
11 Buspirone as a Potential Treatment for Recurrent Central Apneas Terminated NCT00746954 Phase 3 Acetazolamide;Buspirone
12 Dynamic Carbon Dioxide Administration for Central Sleep Apnoea in Heart Failure Unknown status NCT01041924 Phase 2
13 Safety and Efficacy Evaluation of Respicardia Therapy for Central Sleep Apnea Completed NCT01124370 Phase 2
14 A Study to Evaluate the Efficacy of Seattle-PAP for the Respiratory Support of Premature Infants Completed NCT02210026 Phase 1
15 Observational Multicenter Cohort Study of French Patients With a Central or Combined Syndrome of Sleep Apnea With a Predominant Central SAS Treated by Adaptive Servo-Ventilation Unknown status NCT02835638
16 Effect of Adaptive Servoventilation on Cardiac Function, Exercise Tolerance and Quality of Life in Patients With Chronic Heart Failure and Cheyne-Stokes Respiration Unknown status NCT01212705
17 Study of Application of Forced Breath Technique While CPAP Therapy for Apnea Classification Unknown status NCT03432910
18 PHOX2B Mutation-Confirmed Congenital Central Hypoventilation Syndrome in A Chinese Family: Presentations From Newborn to Adulthood Unknown status NCT00652964
19 Central Apnea in Patients Receiving Ticagrelor Unknown status NCT03540459
20 Therapeutic Effect of Desogestrel on Ventilatory Control in Patients With Congenital Central Hypoventilation Syndrome Unknown status NCT01500473 Desogestrel
21 Central Apnoeas in the Course of Transient Ischemic Attack/Ischemic Stroke: Clinical, Prognostic, Pathophysiological Elements. Unknown status NCT01723189
22 Observational and Transversal Study of Patients Treated in "Real Life"Conditions With Adaptive Servo-Ventilation Completed NCT02429986
23 Treatment of Sleep-Disordered Breathing With Predominant Central Sleep Apnea by Adaptive Servo Ventilation in Patients With Heart Failure Completed NCT00733343
24 Central Sleep Apnea and New-onset Cardiac Resynchronization in Patients With Conventional Pacemaker or ICD Therapy: a Multicenter, Randomized Clinical Trial Completed NCT01970423
25 Central Sleep Apnea Treated by CO2 Supplied by a Novel Device Completed NCT04907058
26 BiPAP for Cardiomyopathy With Central Sleep Apnea Completed NCT00282789
27 A Randomized Trial Evaluating the Safety and Effectiveness of the remedē® System in Patients With Central Sleep Apnea Completed NCT01816776
28 Comparison of Adaptive Servo Ventilation(Bipap® Auto SV Advanced) and Oxgen Therapy in Chronic Heart Failure Patients Complicated With Central Sleep Apnea Completed NCT01187823
29 Effectiveness of Adaptive Servoventilation (ASV) in Patients With Central Sleep Apnea Due to Chronic Opioid Use Completed NCT01462084
30 Prospective Multicentre Observational French Cohort Study of Patients With Heart Failure and Central Sleep Apnoea Requiring Adaptive Servo-Ventilation (PaceWave, AutoSet CS) Treatment Completed NCT01831128
31 Comparison of the Somnarus Sleep Apnea Diagnostic Technology SomnaPatch With Polysomnography in Sleep Disordered Breathing Completed NCT02034175
32 Registry on the Treatment of Central and Complex Sleep-Disordered Breathing With Adaptive Servo-Ventilation Completed NCT03032029
33 A Multi-Center Study to Assess the Performance of the Saturation Pattern Detection (SPD) Software Algorithm. Completed NCT00775346
34 Pre-operative PSG Assessment of Cardiac Surgery Inpatients Completed NCT00922168
35 Post Approval Study of the remedē System Completed NCT03425188
36 Heart Function in Patients Assessed for Sleep Disordered Breathing (SDB) Completed NCT03226652
37 Bilevel Versus Servoventilation in Complex Sleep Apnea Completed NCT01609244
38 Effect of Heart Valve Replacement on Cheyne-Stokes Respiration in Patients With Rheumatic Heart Disease Completed NCT01426776
39 Crossover Comparison of Treatment With Continuous Positive Airway Pressure and Treatment With Adaptive Servo Ventilation (SOMNOventCR) in Patients With Underlying Heart Disease, Combined Obstructive Sleep Apnea and Cheyne-Stokes Respiration. Completed NCT00811668
40 Evaluation of Software Enhancements to the Respironics BiPAP autoSV Device Completed NCT00720213
41 Diagnostic Validation of the DreamKit Device Against Polysomnography Completed NCT04671342
42 Evaluation of ApneaLink Plus Scoring Capabilities Completed NCT00823134
43 Evaluation of the Philips Respironics BiPAP autoSV Devices in Subjects With Sleep Disorders. Completed NCT01626989
44 Feasibility of a Variable Carbon Dioxide (CO2) Rebreathe Device ("Smart CO2") to Treat Obstructive Sleep Apnea Completed NCT03552133
45 Validation of the DreamKit Plethysmography-derived Respiratory Effort Signal Against Esophageal Pressure Completed NCT04926077
46 BiPAP (Automatic Servo Ventilation) autoSV Advanced in Central Apnea Patients Completed NCT01199042
47 Validation of Breathing Event Detection of the Philips Respironics Sleep Therapy System REMstar Auto A-Flex Compared to Clinical Polysomnography Completed NCT01175031
48 Evaluation Eines Leg Fluid Shift Und Erörterung Der hämodynamischen Und Respiratorischen Auswirkungen Auf Patienten Mit Chronischer Herzinsuffizienz Und Obstruktiver Oder Zentraler Schlafapnoe Completed NCT03092388
49 Impact of Arterial Oxygen Saturation Range on Ventilatory Stability in Extremely Premature Infants Completed NCT03695900
50 Cognitive Consequences of an Activation of the Cortical Drive to Breath Completed NCT03095729

Search NIH Clinical Center for Central Sleep Apnea

Cochrane evidence based reviews: sleep apnea, central

Genetic Tests for Central Sleep Apnea

Anatomical Context for Central Sleep Apnea

Organs/tissues related to Central Sleep Apnea:

MalaCards : Heart, Spinal Cord, Medulla Oblongata, Kidney, Brain, Lung, Tongue

Publications for Central Sleep Apnea

Articles related to Central Sleep Apnea:

(show top 50) (show all 1271)
# Title Authors PMID Year
Prevalence of obstructive sleep apnea as assessed by polysomnography in psychiatric patients with sleep-related problems. 62
35029795 2022
Evaluation and Treatment of Central Sleep Apnea in Patients with Heart Failure. 62
35995244 2022
Impact of sleep-disordered breathing on the management of children with Chiari malformation type I. 62
35962649 2022
Social impairment and snoring: a unique presentation of pediatric Chiari I malformation. 62
35946419 2022
Central sleep apnea in otherwise healthy term infants. 62
35962944 2022
Design of the remedē System Therapy (rēST) study: A prospective non-randomized post-market study collecting clinical data on safety and effectiveness of the remedē system for the treatment of central sleep apnea. 62
36116293 2022
Effect of adaptive servo ventilation on central sleep apnea and sleep structure in systolic heart failure patients: polysomnography data from the SERVE-HF major sub study. 62
35840352 2022
Sleep architecture and sleep-disordered breathing in fatal insomnia. 62
36182725 2022
Correction to: 0849 Baclofen-induced severe central sleep apnea. 62
36370125 2022
Sleep and Breathing Disturbances in Children With Leigh Syndrome: A Comparative Study. 62
36137349 2022
Mortality Patterns Associated with Central Sleep Apnea Among Veterans: A Large, Retrospective, Longitudinal Report. 62
36375082 2022
Disturbed Sleep is Not Good for the Heart: A Narrative Review. 62
36453501 2022
Impact of Unintentional Air Leaks on Automatic Positive Airway Pressure Device Performance in Simulated Sleep Apnea Events. 62
36347566 2022
Practice recommendations for the role of physiotherapy in the management of sleep disorders: the 2022 Brazilian Sleep Association Guidelines. 62
36419815 2022
Sleep Disorders and Coronary Artery Disease. 62
36301202 2022
Central sleep apnea and daytime sleepiness in Niemann-Pick type C disease: a report of two cases. 62
36199263 2022
Transvenous Phrenic Nerve Stimulation for Central Sleep Apnea. 62
35918232 2022
Severe central sleep apnea in a child with biallelic variants in NALCN. 62
35808948 2022
[Is ASV therapy a positive airway pressure or ventilation therapy? A comparison of acid-base balance per day and under ASV]. 62
36104016 2022
Developing antisense oligonucleotides for a TECPR2 mutation-induced, ultra-rare neurological disorder using patient-derived cellular models. 62
35860385 2022
Central sleep apnea treatment in patients with heart failure with reduced ejection fraction: a network meta-analysis. 62
34698980 2022
Prevalence, clinical characteristics, and predictors of sleep disordered breathing in hospitalized heart failure patients. 62
36177653 2022
Association of OSA with cardiovascular events in women and men with acute coronary syndrome. 62
36104289 2022
SARS-CoV-2 Causing Transient Central Sleep Apnea in Patients Treated for Obstructive Sleep Apnea with Continuous Positive Airway Pressure. 62
36171691 2022
Cheyne-stokes respiration in children with heart failure. 62
35459626 2022
Innovations in Cardiac Implantable Electronic Devices. 62
33651211 2022
Sleep-Disordered Breathing in Adults with Precapillary Pulmonary Hypertension: Prevalence and Predictors of Nocturnal Hypoxemia. 62
35717489 2022
Impact of Sleep-Disordered Breathing Treatment on Ventricular Tachycardia in Patients with Heart Failure. 62
35956183 2022
Sleep-related breathing disorders in idiopathic pulmonary fibrosis are frequent and may be associated with pulmonary vascular involvement. 62
35922615 2022
Phrenic nerve stimulation for the treatment of central sleep apnea in patients with heart failure. 62
35978055 2022
Case of buprenorphine-associated central sleep apnea resolving with dose reduction. 62
36052936 2022
The Pathogenesis of Central and Complex Sleep Apnea. 62
35588042 2022
Sleep-disordered breathing in pediatric neurofibromatosis type 1. 62
35278041 2022
PAP therapy and readmission rates after in-hospital laboratory titration polysomnography in patients with hypoventilation. 62
35332871 2022
Sleep-disordered breathing in heart failure patients with different etiologies. 62
35535628 2022
A Word of Caution: Adenotonsillectomy May Help Reduce Central Apneas, but It Is Not a Treatment for Central Sleep Apnea. 62
35642622 2022
Correction to: Improving Nocturnal Hypoxemic Burden with Transvenous Phrenic Nerve Stimulation for the Treatment of Central Sleep Apnea. 62
34761354 2022
Altitude-Induced Sleep Apnea Is Highly Dependent on Ethnic Background (Sherpa Vs. Tamang). 62
35708530 2022
Central Sleep Apnea: Pathophysiologic Classification. 62
35551411 2022
The impact of sleep disordered breathing on cardiac troponin in acutely decompensated heart failure. 62
35641808 2022
Elevated serum matrix metalloproteinase-2 levels in heart failure patients with reduced ejection fraction and Cheyne-Stokes respiration. 62
35023473 2022
Transvenous Phrenic Nerve Stimulation for Central Sleep Apnea: Clinical and Billing Review. 62
34808108 2022
Patient Related Outcome and Therapy Effects in Stimulation Treatment of Sleep-Related Breathing Disorders. 62
35605615 2022
Abnormalities of the Vertebrobasilar Arterial System Leading to Sleep Disorders. 62
35190307 2022
Sleep Breathing Disorders in Heart Failure. 62
35465892 2022
Obstructive sleep apnea and nocturnal attacks of paroxysmal atrial fibrillation. 62
34931608 2022
Sleep-disordered breathing in school-aged children with Prader-Willi syndrome. 62
34870583 2022
Average volume-assured pressure support for patients with obstructive sleep apnea with failed CPAP titration. 62
35371406 2022
Prevalence and clinical characteristics of sleep-disordered breathing in patients with heart failure of different left ventricular ejection fractions. 62
35394577 2022
Diagnostic and therapeutic approach of central sleep apnea in heart failure - the role of adaptive servo-ventilation. A statement of the Portuguese society of pulmonology and the Portuguese sleep association. 62
35501278 2022

Variations for Central Sleep Apnea

Expression for Central Sleep Apnea

Search GEO for disease gene expression data for Central Sleep Apnea.

Pathways for Central Sleep Apnea

GO Terms for Central Sleep Apnea

Biological processes related to Central Sleep Apnea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 regulation of resting membrane potential GO:0060075 9.62 NALCN KCNK3
2 negative regulation of lipid storage GO:0010888 9.56 LEP CRP
3 angiotensin maturation GO:0002003 9.46 REN ACE
4 eating behavior GO:0042755 9.43 LEP HCRT ACE
5 regulation of blood pressure GO:0008217 9.23 REN NPPB LEP ACE

Sources for Central Sleep Apnea

8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
27 GO
28 GTR
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
36 LifeMap
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
70 Tocris
72 UMLS via Orphanet
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