Central Sleep Apnea

Categories: Mental diseases, Neuronal diseases, Respiratory diseases

Aliases & Classifications for Central Sleep Apnea

MalaCards integrated aliases for Central Sleep Apnea:

Name: Central Sleep Apnea 12 15
Central Sleep Apnea Syndrome 12 29 6 72
Sleep Apnea, Central 44 72
Central Sleep Apnea, Primary 72
Primary Central Sleep Apnea 12


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Disease Ontology 12 DOID:9220
MeSH 44 D020182
NCIt 50 C116046
UMLS 72 C0520680 C0751762 C3887547

Summaries for Central Sleep Apnea

Disease Ontology : 12 A sleep apnea that is characterized by a malfunction of the basic neurological controls for breathing rate and the failure to give the signal to inhale, causing the individual to miss one or more cycles of breathing.

MalaCards based summary : Central Sleep Apnea, also known as central sleep apnea syndrome, is related to sleep apnea and systolic heart failure, and has symptoms including apnea An important gene associated with Central Sleep Apnea is CHAT (Choline O-Acetyltransferase), and among its related pathways/superpathways are Prolactin Signaling Pathway and AGE/RAGE pathway. The drugs Zopiclone and tannic acid have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and spinal cord, and related phenotypes are behavior/neurological and cardiovascular system

Wikipedia : 75 Central sleep apnea (CSA) or central sleep apnea syndrome (CSAS) is a sleep-related disorder in which... more...

Related Diseases for Central Sleep Apnea

Diseases in the Sleep Apnea family:

Central Sleep Apnea

Diseases related to Central Sleep Apnea via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 149)
# Related Disease Score Top Affiliating Genes
1 sleep apnea 32.3 NPPB NOS3 LEP
2 systolic heart failure 30.8 NPPB HSPB7
3 mitral valve insufficiency 30.6 NPPB NPPA
4 heart valve disease 30.3 NPPB NPPA
5 pulmonary edema 29.7 NPPB NPPA NOS3
6 kidney disease 29.5 NPPB NPPA NOS3
7 dilated cardiomyopathy 29.3 NPPB NPPA NOS3 HSPB7
8 pulmonary hypertension 29.2 NPPB NPPA NOS3 KCNK3
9 idiopathic alveolar hypoventilation syndrome 12.0
10 chiari malformation 11.7
11 chiari malformation type i 11.7
12 chiari malformation type ii 11.6
13 congestive heart failure 10.9
14 heart disease 10.8
15 sleep disorder 10.4
16 apnea, obstructive sleep 10.4
17 respiratory failure 10.4
18 anterolateral myocardial infarction 10.3 NPPB NPPA
19 syndrome of inappropriate antidiuretic hormone 10.3 NPPB NPPA
20 chronic kidney disease 10.3
21 mitral valve stenosis 10.3 NPPB NPPA
22 syncope 10.3 NPPB NPPA
23 idiopathic edema 10.3 NPPB NPPA
24 apnea, central sleep 10.3
25 atrial fibrillation 10.3
26 obesity-hypoventilation syndrome 10.2
27 mixed sleep apnea 10.2
28 chronic pain 10.2
29 pericardial effusion 10.2 NPPB NPPA
30 coronary heart disease 1 10.1
31 end stage renal failure 10.1
32 autonomic dysfunction 10.1
33 hypotonia 10.1
34 chronic mountain sickness 10.1 NPPB NOS3
35 toxic myocarditis 10.1 NPPB NOS3
36 vasculogenic impotence 10.1 NPPA NOS3
37 aortic valve disease 2 10.1 NPPB NPPA
38 multiple sclerosis 10.1
39 stiff-person syndrome 10.1
40 central hypoventilation syndrome, congenital 10.1
41 pulmonary disease, chronic obstructive 10.1
42 atrioventricular block 10.1
43 hydrocephalus 10.1
44 hypothyroidism 10.1
45 craniosynostosis 10.1
46 arteriosclerosis 10.1
47 acromegaly 10.1
48 cerebrovascular disease 10.1
49 narcolepsy 10.1
50 congenital hydrocephalus 10.1

Graphical network of the top 20 diseases related to Central Sleep Apnea:

Diseases related to Central Sleep Apnea

Symptoms & Phenotypes for Central Sleep Apnea

UMLS symptoms related to Central Sleep Apnea:


MGI Mouse Phenotypes related to Central Sleep Apnea:

# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.8 CHAT HSPB7 KCNK3 LEP NOS3 SRC
2 cardiovascular system MP:0005385 9.73 CHAT HSPB7 KCNK3 LEP NOS3 NPPA
3 limbs/digits/tail MP:0005371 9.46 CHAT LEP NOS3 SRC
4 muscle MP:0005369 9.35 CHAT HSPB7 LEP NOS3 NPPA
5 respiratory system MP:0005388 9.1 CHAT HSPB7 KCNK3 LEP NOS3 SRC

Drugs & Therapeutics for Central Sleep Apnea

Drugs for Central Sleep Apnea (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 85)
# Name Status Phase Clinical Trials Cas Number PubChem Id
Zopiclone Approved Phase 4 43200-80-2 5735
tannic acid Approved Phase 4 1401-55-4
Trazodone Approved, Investigational Phase 4 19794-93-5 5533
Benzocaine Approved, Investigational Phase 4 94-09-7, 1994-09-7 2337
Losartan Approved Phase 4 114798-26-4 3961
Angiotensin II Approved, Investigational Phase 4 11128-99-7, 68521-88-0, 4474-91-3 172198
Guaifenesin Approved, Investigational, Vet_approved Phase 4 93-14-1 3516
Opium Approved, Illicit Phase 4 8008-60-4
Loperamide Approved Phase 4 53179-11-6 3955
10 Serotonin Uptake Inhibitors Phase 4
11 Antidepressive Agents Phase 4
12 Antidepressive Agents, Second-Generation Phase 4
13 Neurotransmitter Uptake Inhibitors Phase 4
14 Angiotensinogen Phase 4
15 Angiotensin Receptor Antagonists Phase 4
16 Angiotensin II Type 1 Receptor Blockers Phase 4
17 Giapreza Phase 4
18 Anti-Arrhythmia Agents Phase 4
19 Antihypertensive Agents Phase 4
20 Analgesics, Opioid Phase 4
21 Gastrointestinal Agents Phase 4
22 Opium Poppy Phase 4
23 Respiratory System Agents Phase 4
24 Chlorpheniramine, phenylpropanolamine drug combination Phase 4
25 Antitussive Agents Phase 4
26 Antidiarrheals Phase 4
Desogestrel Approved Phase 2, Phase 3 54024-22-5 40973
Fluoxetine Approved, Vet_approved Phase 3 54910-89-3 3386
Acetazolamide Approved, Vet_approved Phase 3 59-66-5 1986
Buspirone Approved, Investigational Phase 3 36505-84-7 2477
31 Hormone Antagonists Phase 2, Phase 3
32 Contraceptives, Oral Phase 2, Phase 3
33 Contraceptive Agents Phase 2, Phase 3
34 Hormones Phase 2, Phase 3
35 Progestins Phase 2, Phase 3
36 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 2, Phase 3
37 Cytochrome P-450 CYP2D6 Inhibitors Phase 3
38 Cytochrome P-450 Enzyme Inhibitors Phase 3
39 Central Nervous System Depressants Phase 3
40 Neurotransmitter Agents Phase 3
41 Natriuretic Agents Phase 3
42 diuretics Phase 3
43 Anticonvulsants Phase 3
44 Carbonic Anhydrase Inhibitors Phase 3
45 Tranquilizing Agents Phase 3
46 Anti-Anxiety Agents Phase 3
47 Serotonin Agents Phase 3
48 Psychotropic Drugs Phase 3
49 Serotonin Receptor Agonists Phase 3
Serotonin Investigational, Nutraceutical Phase 3 50-67-9 5202

Interventional clinical trials:

(show top 50) (show all 96)
# Name Status NCT ID Phase Drugs
1 Adaptative Servoventilation Compliance in Left Ventricular Dysfunction Patients With Central Sleep Apnea: Benefit of One Month Hypnotic (Zopiclone) Versus Placebo Unknown status NCT02820441 Phase 4 Zopiclone;Placebo
2 Cardiac Resynchronisation Therapy in Combination With Overdrive Pacing in the Treatment of Central Sleep Apnea in CHF Completed NCT00551499 Phase 4
3 Treatment of Sleep-Disordered Breathing With Predominant Central Sleep Apnea by Adaptive Servo Ventilation in Patients With Heart Failure Completed NCT00733343 Phase 4
4 Comparison of Therapeutic Oxygen Versus Medical Air for the Treatment of Central Sleep Apnea in Infants and Children With Prader Willi Syndrome: A Proof of Concept Study Recruiting NCT03031626 Phase 4
5 A Multi-Centre, Randomized Study to Assess the Effects of Adaptive Servo Ventilation (ASV) on Survival and Frequency of Hospital Admissions in Patients With Heart Failure (HF) and Sleep Apnea (SA)-The ADVENT-HF Trial Recruiting NCT01128816 Phase 4
6 Evaluation of Nocturnal Oxygen Needs in the Treatment of Central Sleep Apnea in Patients With Chronic Heart Failure. Recruiting NCT03254212 Phase 4
7 Oxygen Versus PAP for Treatment of Sleep Apnea in Chronic Heart Failure Recruiting NCT01807897 Phase 4
8 Treatment of Sleep Apnea in Patients With Cervical Spinal Cord Injury Recruiting NCT02922894 Phase 4 Trazodone;Placebo
9 Effect of Angiotensin Receptor Blockers on Periodic Breathing During Sleep in Hypoxia Active, not recruiting NCT03335904 Phase 4 Losartan;Placebo
10 Effect of Acetazolamide on Central Sleep Apnea Related to Opium Consumption Enrolling by invitation NCT02371473 Phase 4 Acetazolamide-placebo;Placebo-acetazolamide
11 Effect of Servo-Ventilation on CO2 Regulation and Heart Rate Variability Not yet recruiting NCT03890939 Phase 4
12 Bilevel Positive Pressure Ventilation (BIPAP)in Patients With Sleep Disorders Breathing (SDB)and Congestive Heart Failure (CHF):Comparison of Two Diagnostic Methods Unknown status NCT01501734 Phase 3
13 Efficacy of Fluoxetine Against Seizure-induced Central Apneas : a Randomized Placebo-controled Double-blind Trial. Completed NCT02569970 Phase 3 fluoxetine 20 mg;placebo 20 mg
14 Assessment of Desogestrel for a Pharmacological Recovery of Ventilatory Activity in Congenital Central Hypoventilation Syndrome - Ondine Syndrome Completed NCT01243697 Phase 2, Phase 3 desogestrel
15 The Impact of Low Flow Nocturnal Oxygen Therapy on Hospital Admissions and Mortality in Patients With Heart Failure and Central Sleep Apnea (LOFT-HF) Recruiting NCT03745898 Phase 3 Oxygen
16 Buspirone as a Potential Treatment for Recurrent Central Apneas Terminated NCT00746954 Phase 3 Acetazolamide;Buspirone
17 High-Flow-Therapy for the Treatment of Cheyne-Stokes-Respiration in Chronic Heart Failure Terminated NCT03102827 Phase 3 Oxygen
18 Dynamic Carbon Dioxide Administration for Central Sleep Apnoea in Heart Failure Unknown status NCT01041924 Phase 2
19 Safety and Efficacy Evaluation of Respicardia Therapy for Central Sleep Apnea Completed NCT01124370 Phase 2
20 Improving Sleep and Functioning in Veterans With Posttraumatic Stress Disorder Not yet recruiting NCT04007796 Phase 2
21 Outcome and Treatment of Complex Sleep Apnea Withdrawn NCT01137214 Phase 2
22 A Study to Evaluate the Efficacy of Seattle-PAP for the Respiratory Support of Premature Infants Completed NCT02210026 Phase 1
23 Interface Selection for Adaptive Servo Ventilation: A Randomized Controlled Study Unknown status NCT02919930
24 Effect of Adaptive Servoventilation on Cardiac Function, Exercise Tolerance and Quality of Life in Patients With Chronic Heart Failure and Cheyne-Stokes Respiration Unknown status NCT01212705
25 PHOX2B Mutation-Confirmed Congenital Central Hypoventilation Syndrome in A Chinese Family: Presentations From Newborn to Adulthood Unknown status NCT00652964
26 Sleep Breathing Disorders, a Main Trigger for Cardiac ARythmias in Type I Myotonic Dystrophy ? Unknown status NCT02375087
27 Therapeutic Effect of Desogestrel on Ventilatory Control in Patients With Congenital Central Hypoventilation Syndrome Unknown status NCT01500473 Desogestrel
28 Central Apnoeas in the Course of Transient Ischemic Attack/Ischemic Stroke: Clinical, Prognostic, Pathophysiological Elements. Unknown status NCT01723189
29 Diagnosis And Treatment of Sleep Apnea in Patient With Heart Failure DASAP-HF Study Unknown status NCT02620930
30 Non-Invasive Measurement of Respiratory Effort Unknown status NCT00528749
31 Observational and Transversal Study of Patients Treated in "Real Life"Conditions With Adaptive Servo-Ventilation Completed NCT02429986
32 A Randomized Trial Evaluating the Safety and Effectiveness of the remedē® System in Patients With Central Sleep Apnea Completed NCT01816776
33 Bilevel Versus Servoventilation in Complex Sleep Apnea Completed NCT01609244
34 Pre-operative PSG Assessment of Cardiac Surgery Inpatients Completed NCT00922168
35 Comparison of Adaptive Servo Ventilation(Bipap® Auto SV Advanced) and Oxgen Therapy in Chronic Heart Failure Patients Complicated With Central Sleep Apnea Completed NCT01187823
36 A Multi-Center Study to Assess the Performance of the Saturation Pattern Detection (SPD) Software Algorithm. Completed NCT00775346
37 BiPAP (Automatic Servo Ventilation) autoSV Advanced in Central Apnea Patients Completed NCT01199042
38 Effect of Heart Valve Replacement on Cheyne-Stokes Respiration in Patients With Rheumatic Heart Disease Completed NCT01426776
39 Effectiveness of Adaptive Servoventilation (ASV) in Patients With Central Sleep Apnea Due to Chronic Opioid Use Completed NCT01462084
40 Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude. Completed NCT03368352 Early Phase 1
41 Evaluation of Software Enhancements to the Respironics BiPAP autoSV Device Completed NCT00720213
42 Comparison of the Somnarus Sleep Apnea Diagnostic Technology SomnaPatch With Polysomnography in Sleep Disordered Breathing Completed NCT02034175
43 Crossover Comparison of Treatment With Continuous Positive Airway Pressure and Treatment With Adaptive Servo Ventilation (SOMNOventCR) in Patients With Underlying Heart Disease, Combined Obstructive Sleep Apnea and Cheyne-Stokes Respiration. Completed NCT00811668
44 Effects of Melatonin on Sleep, Ventilatory Control and Cognition at Altitude Completed NCT03588676
45 The First Affiliated Hospital of Nanjing Medical University Completed NCT02349997
46 Different Loop Gain Phenotypes in Patients With Chronic Systolic Heart Failure and Periodic Breathing Completed NCT03532412
47 BiPAP for Cardiomyopathy With Central Sleep Apnea Completed NCT00282789
48 Evaluation Eines Leg Fluid Shift Und Erörterung Der hämodynamischen Und Respiratorischen Auswirkungen Auf Patienten Mit Chronischer Herzinsuffizienz Und Obstruktiver Oder Zentraler Schlafapnoe Completed NCT03092388
49 Late-onset, Insidious Course and Invasive Treatment of Congenital Central Hypoventilation Syndrome in a Case With the Phox2B Mutation Completed NCT01225679
50 Alarm Relay Bracelet for Simplification and Security Respiratory Assistance at Home: Evaluation of the Nocturnal Awakening Capability in Ventilated Patients and Healthy Volunteers Completed NCT03053011

Search NIH Clinical Center for Central Sleep Apnea

Cochrane evidence based reviews: sleep apnea, central

Genetic Tests for Central Sleep Apnea

Genetic tests related to Central Sleep Apnea:

# Genetic test Affiliating Genes
1 Central Sleep Apnea Syndrome 29

Anatomical Context for Central Sleep Apnea

MalaCards organs/tissues related to Central Sleep Apnea:

Heart, Kidney, Spinal Cord, Brain, Lung, Eye, Tongue

Publications for Central Sleep Apnea

Articles related to Central Sleep Apnea:

(show top 50) (show all 991)
# Title Authors PMID Year
New-generation positional therapy in patients with positional central sleep apnea. 38
31302742 2019
Detecting central sleep apnea in adult patients using WatchPAT-a multicenter validation study. 38
31402439 2019
Interventional techniques to increase implantation success of transvenous phrenic nerve stimulation for central sleep apnea treatment. 38
31407159 2019
Role of sleep study in children with Chiari malformation and sleep disordered breathing. 38
31372737 2019
Central sleep apnea in children with obstructive sleep apnea syndrome and improvement following adenotonsillectomy. 38
31373175 2019
Treatment and persistence/recurrence of sleep-disordered breathing in children with Down syndrome. 38
31172656 2019
Extended evaluation of the efficacy of a proactive forced oscillation technique-based auto-CPAP algorithm. 38
31388800 2019
How to organise teaching activities for the scoring of cardiorespiratory polygraphies? Experiences from three Swedish Sleep Society teaching courses. 38
30246416 2019
Sleep Disorders in Hereditary Ataxias. 38
31342187 2019
Heterogeneity of Periodic Limb Movements Associated With Central Sleep Apnea in Heart Failure Patients. 38
31029412 2019
Sleep apnea assessment using declination duration-based global metrics from unobtrusive fiber optic sensors. 38
31361598 2019
Emergence of Central Sleep Apnea Events After Maxillomandibular Advancement Surgery for Obstructive Sleep Apnea. 38
31302064 2019
[Association between mixed sleep apnea and treatment-emergent central sleep apnea]. 38
31269581 2019
Diagnosis and management of central sleep apnea syndrome. 38
31014146 2019
High Incidence of Sleep-Related Breathing Disorders in Children with Down Syndrome Referred to a High-Altitude Sleep Laboratory. 38
31259618 2019
Association of serious adverse events with Cheyne-Stokes respiration characteristics in patients with systolic heart failure and central sleep apnoea: A SERVE-Heart Failure substudy analysis. 38
31218793 2019
Successful screening of sleep-disordered breathing using a pacemaker-based algorithm in Japan. 38
30630655 2019
Therapeutic effects of CPAP on cognitive impairments associated with OSA. 38
31111204 2019
Phrenic nerve stimulation in patients with central sleep apnea: a single‑center experience from pilot and pivotal trials evaluating the remedē System. 38
30964196 2019
How to implant a phrenic nerve stimulator for treatment of central sleep apnea? 38
30834611 2019
Diagnosis, management and pathophysiology of central sleep apnea in children. 38
30170958 2019
Tongue Stabilizing Device-Emergent Central Sleep Apnea: A Case Report. 38
30952219 2019
Persistent Central Apnea and Long-Term Outcome After Posterior Fossa Decompressive Surgery for Arnold Chiari Type 1 Malformation in a Pediatric Patient. 38
30952227 2019
Pierre Robin Sequence. 38
30851756 2019
Biallelic loss-of-function P4HTM gene variants cause hypotonia, hypoventilation, intellectual disability, dysautonomia, epilepsy, and eye abnormalities (HIDEA syndrome). 38
30940925 2019
Relationship of stroke volume to different patterns of Cheyne-Stokes respiration in heart failure. 38
30946471 2019
Influenza virus and factors that are associated with ICU admission, pulmonary co-infections and ICU mortality. 38
30481669 2019
Apneas of Heart Failure and Phenotype-Guided Treatments: Part One: OSA. 38
31047953 2019
Beneficial effects of adaptive servo-ventilation on natriuretic peptides and diastolic function in acute heart failure patients with preserved ejection fraction and sleep-disordered breathing. 38
29948858 2019
Acetazolamide Therapy in Patients with Heart Failure: A Meta-Analysis. 38
30871038 2019
Central Sleep Apnea With Sodium Oxybate in a Pediatric Patient. 38
30853045 2019
Polysomnographic Analysis of a Pediatric Case of Baclofen-Induced Central Sleep Apnea. 38
30736882 2019
Effect of Adaptive Servo-Ventilation on Periodic Limb Movements in Sleep in Patients With Heart Failure. 38
30554649 2019
Prevalence and Factors Contributing to Daytime and Nocturnal Hypoxemia in Chronic Heart Failure Patients. 38
30654381 2019
Effects of Adaptive Servoventilation Therapy for Central Sleep Apnea on Health Care Utilization and Mortality: A Population-Based Study. 38
30621843 2019
In patients with heart failure the burden of central sleep apnea increases in the late sleep hours. 38
30325462 2019
Polysomnography. 38
31277862 2019
Sleep Disturbance as Potential Risk and Progression Factor for Parkinson's Disease. 38
31227656 2019
More than Heart Failure: Central Sleep Apnea and Sleep-Related Hypoventilation. 38
31291632 2019
Comparative Evaluation of Therapeutic Approaches to Central Sleep Apnea. 38
30993083 2019
[Central sleep apnea in patients with chronic heart failure]. 38
31317922 2019
Central sleep apnea: misunderstood and mistreated! 38
31297185 2019
Death in patients with adaptive servo-ventilation for sleep apnea and no specific SERVE-HF profile: A case series study. 38
30555779 2019
CO2-related vasoconstriction superimposed on ischemic medullary brain autonomic nuclei may contribute to sudden death. 38
30466068 2019
[Transvenous neurostimulation in central sleep apnea associated with heart failure]. 38
30306302 2018
Cycle length identifies obstructive sleep apnea and central sleep apnea in heart failure with reduced ejection fraction. 38
29637409 2018
Targeting volume overload and overnight rostral fluid shift: A new perspective to treat sleep apnea. 38
30177246 2018
Postoperative complications after elective coronary artery bypass grafting surgery in patients with sleep-disordered breathing. 38
29943269 2018
Sleep-disordered breathing in patients with cardiovascular diseases cannot be detected by ESS, STOP-BANG, and Berlin questionnaires. 38
29845331 2018
Diagnosis and perioperative management in pediatric sleep-disordered breathing. 38
30281185 2018

Variations for Central Sleep Apnea

ClinVar genetic disease variations for Central Sleep Apnea:

# Gene Variation Type Significance SNP ID GRCh37 Pos GRCh38 Pos
1 CHAT NM_020549.4(CHAT): c.2081C> G (p.Ser694Cys) single nucleotide variant Pathogenic rs201439531 10:50872926-50872926 10:49664880-49664880
2 CHAT NM_020549.4(CHAT): c.1061C> T (p.Thr354Met) single nucleotide variant Conflicting interpretations of pathogenicity rs769234940 10:50835781-50835781 10:49627735-49627735

Expression for Central Sleep Apnea

Search GEO for disease gene expression data for Central Sleep Apnea.

Pathways for Central Sleep Apnea

GO Terms for Central Sleep Apnea

Cellular components related to Central Sleep Apnea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 caveola GO:0005901 8.62 SRC NOS3

Biological processes related to Central Sleep Apnea according to GeneCards Suite gene sharing:

(show all 11)
# Name GO ID Score Top Affiliating Genes
1 response to insulin GO:0032868 9.49 NPPA LEP
2 positive regulation of phosphatidylinositol 3-kinase signaling GO:0014068 9.48 SRC LEP
3 response to nutrient levels GO:0031667 9.46 SRC LEP
4 regulation of nitric-oxide synthase activity GO:0050999 9.43 NOS3 LEP
5 positive regulation of insulin receptor signaling pathway GO:0046628 9.4 SRC LEP
6 receptor guanylyl cyclase signaling pathway GO:0007168 9.37 NPPB NPPA
7 cGMP biosynthetic process GO:0006182 9.32 NPPB NPPA
8 regulation of vascular permeability GO:0043114 9.26 SRC NPPB
9 ovulation from ovarian follicle GO:0001542 9.16 NOS3 LEP
10 regulation of blood vessel size GO:0050880 9.13 NPPB NPPA NOS3
11 regulation of blood pressure GO:0008217 8.92 NPPB NPPA NOS3 LEP

Molecular functions related to Central Sleep Apnea according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 signaling receptor binding GO:0005102 9.46 SRC NPPB NPPA LEP
2 protein C-terminus binding GO:0008022 9.43 SRC KCNK3 HSPB7
3 scaffold protein binding GO:0097110 9.32 SRC NOS3
4 hormone activity GO:0005179 9.13 NPPB NPPA LEP
5 hormone receptor binding GO:0051427 8.62 NPPB NPPA

Sources for Central Sleep Apnea

9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
32 HPO
33 ICD10
34 ICD10 via Orphanet
38 LifeMap
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
55 Novoseek
58 OMIM via Orphanet
62 PubMed
71 Tocris
73 UMLS via Orphanet
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