MCID: CPH004
MIFTS: 36

Cephalosporin Allergy

Categories: Immune diseases

Aliases & Classifications for Cephalosporin Allergy

MalaCards integrated aliases for Cephalosporin Allergy:

Name: Cephalosporin Allergy 12 15

Classifications:



External Ids:

Disease Ontology 12 DOID:0040021
UMLS 74 C0571444

Summaries for Cephalosporin Allergy

Disease Ontology : 12 A drug allergy that has_allergic_trigger cephalosporin.

MalaCards based summary : Cephalosporin Allergy is related to ceftriaxone allergy and cefotaxime allergy. An important gene associated with Cephalosporin Allergy is TGFBR1 (Transforming Growth Factor Beta Receptor 1), and among its related pathways/superpathways are PEDF Induced Signaling and TGF-Beta Pathway. The drugs Cefazolin and Clindamycin have been mentioned in the context of this disorder. Affiliated tissues include skin, t cells and testes, and related phenotypes are digestive/alimentary and embryo

Related Diseases for Cephalosporin Allergy

Diseases related to Cephalosporin Allergy via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 154)
# Related Disease Score Top Affiliating Genes
1 ceftriaxone allergy 11.3
2 cefotaxime allergy 11.3
3 cefaclor allergy 11.3
4 ceftazidime allergy 11.3
5 cefuroxime allergy 11.3
6 cefixime allergy 11.3
7 cefotiam allergy 11.3
8 transient hypogammaglobulinemia 10.2 IL10 TGFBR1
9 penicillin allergy 10.1
10 transient hypogammaglobulinemia of infancy 10.1 IL10 TGFBR1
11 necatoriasis 10.1 IL10 IL5
12 cow milk allergy 10.1 IL10 IL5
13 milk allergy 10.1 IL10 IL5
14 apple allergy 10.1 IL10 IL5
15 gaucher disease, type ii 10.1 IL10 IL5
16 eosinophilic meningitis 10.1 IL10 IL5
17 filarial elephantiasis 10.1 IL10 IL5
18 pneumonia 10.1 IL10 IL5
19 radiculopathy 10.1 IL10 IL5
20 churg-strauss syndrome 10.1 IL10 IL5
21 nasal cavity disease 10.1 IL10 IL5
22 nose disease 10.1 IL10 IL5
23 respiratory allergy 10.0 IL10 IL5
24 parasitic helminthiasis infectious disease 10.0 IL10 IL5
25 gastroenteritis 10.0 IL10 IL5
26 bronchial disease 10.0 IL10 IL5
27 castleman disease 10.0 IFNG IL10
28 hyperlucent lung 10.0 IFNG IL10
29 sporotrichosis 10.0 IFNG IL10
30 baylisascariasis 10.0 IFNG IL10
31 chronic graft versus host disease 10.0 IFNG IL10
32 clonorchiasis 10.0 IFNG IL10
33 pericardial tuberculosis 10.0 IFNG IL10
34 tuberculoid leprosy 10.0 IFNG IL10
35 fungal meningitis 10.0 IFNG IL10
36 meningitis 10.0 IFNG IL10
37 chronic active epstein-barr virus infection 10.0 IFNG IL10
38 peanut allergy 10.0 IFNG IL10
39 fascioliasis 10.0 IFNG IL10
40 intermediate uveitis 10.0 IFNG IL10
41 uveitis 10.0 IFNG IL10
42 orofacial granulomatosis 10.0 IFNG IL10
43 buruli ulcer 10.0 IFNG IL10
44 primary systemic mycosis 10.0 IFNG IL10
45 hand, foot and mouth disease 10.0 IFNG IL10
46 mouth disease 10.0 IFNG IL10
47 mycoplasma pneumoniae pneumonia 10.0 IFNG IL10
48 poliomyelitis 10.0 IFNG IL10
49 eales disease 10.0 IFNG IL10
50 spotted fever 10.0 IFNG IL10

Graphical network of the top 20 diseases related to Cephalosporin Allergy:



Diseases related to Cephalosporin Allergy

Symptoms & Phenotypes for Cephalosporin Allergy

MGI Mouse Phenotypes related to Cephalosporin Allergy:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 digestive/alimentary MP:0005381 9.56 IFNG IL10 IL5 TGFBR1
2 embryo MP:0005380 9.46 IFNG IL10 IL5 TGFBR1
3 neoplasm MP:0002006 9.26 IFNG IL10 IL5 TGFBR1
4 respiratory system MP:0005388 8.92 IFNG IL10 IL5 TGFBR1

Drugs & Therapeutics for Cephalosporin Allergy

Drugs for Cephalosporin Allergy (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 9)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Cefazolin Approved Not Applicable 25953-19-9 33255 656510
2
Clindamycin Approved, Vet_approved Not Applicable 18323-44-9 29029
3
Azithromycin Approved Not Applicable 83905-01-5 447043 55185
4 Anti-Bacterial Agents ,Not Applicable
5 Anti-Infective Agents
6 Cephalosporins
7 Clindamycin palmitate Not Applicable
8 Clindamycin phosphate Not Applicable
9 Antibiotics, Antitubercular Not Applicable

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Skin Testing and ELISPOT Assay in Patients With a History of Non-Immediate Reactions to Cephalosporins Completed NCT01248377
2 Study of Effectiveness and Safety of Azithromycin-based Extended-spectrum Prophylaxis to Prevent Post Cesarean Infection Completed NCT01235546 Not Applicable Azithromycin and standard of care;Placebo and standard of care

Search NIH Clinical Center for Cephalosporin Allergy

Genetic Tests for Cephalosporin Allergy

Anatomical Context for Cephalosporin Allergy

MalaCards organs/tissues related to Cephalosporin Allergy:

42
Skin, T Cells, Testes, Lung, Bone

Publications for Cephalosporin Allergy

Articles related to Cephalosporin Allergy:

(show all 14)
# Title Authors Year
1
Immediate Cephalosporin Allergy. ( 30667130 )
2019
2
Subgroups in cephalosporin allergy, making a patient-tailored approach redundant? ( 26553410 )
2016
3
Impact of a clinical guideline for prescribing antibiotics to inpatients reporting penicillin or cephalosporin allergy. ( 26070805 )
2015
4
Penicillin and cephalosporin allergy. ( 24767695 )
2014
5
Penicillin allergy might not be very common in subjects with cephalosporin allergy. ( 21397308 )
2011
6
Summaries for patients. Cephalosporin allergy in patients with penicillin allergy. ( 15238392 )
2004
7
Cephalosporin allergy. ( 15242721 )
2004
8
Cephalosporin allergy. ( 11821523 )
2002
9
Cephalosporin allergy. ( 11824423 )
2002
10
Cephalosporin allergy. ( 11824424 )
2002
11
Cephalosporin allergy. ( 11556301 )
2001
12
Diagnosis of penicillin, amoxicillin, and cephalosporin allergy: reliability of examination assessed by skin testing and oral challenge. ( 9470015 )
1998
13
Chemical reactions in cephalosporin allergy: high-pressure liquid chromatographic analysis of cephalosporin aminolysis kinetics. ( 430501 )
1979
14
Chemical studies related to cephalosporin allergy. II. Competitive amine-catalyzed intra- and intermolecular aminolysis of cephalexin and cephaloglycin in aqueous solution. ( 11639 )
1976

Variations for Cephalosporin Allergy

Expression for Cephalosporin Allergy

Search GEO for disease gene expression data for Cephalosporin Allergy.

Pathways for Cephalosporin Allergy

Pathways related to Cephalosporin Allergy according to GeneCards Suite gene sharing:

(show all 34)
# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.26 IFNG IL10 IL5 TGFBR1
2
Show member pathways
13.11 IFNG IL10 IL5 TGFBR1
3
Show member pathways
12.76 IFNG IL10 TGFBR1
4
Show member pathways
12.55 IFNG IL10 IL5
5 12.49 IFNG IL5 TGFBR1
6
Show member pathways
12.19 IFNG IL10 IL5
7
Show member pathways
12.16 IFNG IL10 IL5 TGFBR1
8
Show member pathways
12.04 IFNG IL10 IL5
9
Show member pathways
11.8 IL10 TGFBR1
10 11.77 IFNG TGFBR1
11
Show member pathways
11.77 IFNG IL10 IL5 TGFBR1
12
Show member pathways
11.75 IFNG IL10 TGFBR1
13
Show member pathways
11.68 IFNG IL10 IL5 TGFBR1
14 11.67 IFNG IL10 IL5
15 11.63 IFNG IL10
16 11.62 IFNG TGFBR1
17 11.6 IFNG IL10
18 11.55 IFNG IL5
19 11.51 IL10 IL5
20
Show member pathways
11.5 IFNG IL5
21 11.48 IFNG IL10
22 11.48 IFNG IL10 IL5
23 11.46 IFNG IL10
24 11.4 IL10 IL5
25 11.35 IFNG TGFBR1
26 11.26 IFNG IL10
27 11.21 IL10 TGFBR1
28 11.2 IFNG TGFBR1
29 11.1 IFNG IL10
30 11.04 IFNG IL5
31 11.02 IFNG IL5
32 10.99 IFNG IL10 IL5
33 10.59 IFNG IL10 IL5
34 10.21 IFNG IL10 IL5

GO Terms for Cephalosporin Allergy

Biological processes related to Cephalosporin Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.58 IL10 IL5 TGFBR1
2 cell cycle arrest GO:0007050 9.46 IFNG TGFBR1
3 positive regulation of DNA-binding transcription factor activity GO:0051091 9.43 IL10 IL5
4 positive regulation of cell proliferation GO:0008284 9.43 IFNG IL5 TGFBR1
5 regulation of growth GO:0040008 9.37 IFNG TGFBR1
6 immune response GO:0006955 9.33 IFNG IL10 IL5
7 positive regulation of endothelial cell proliferation GO:0001938 9.32 IL10 TGFBR1
8 regulation of signaling receptor activity GO:0010469 9.13 IFNG IL10 IL5
9 interleukin-12-mediated signaling pathway GO:0035722 8.62 IFNG IL10

Molecular functions related to Cephalosporin Allergy according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytokine activity GO:0005125 8.8 IFNG IL10 IL5

Sources for Cephalosporin Allergy

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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