Cercarial Dermatitis disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

CDC: ² Swimmer's itch, also called cercarial dermatitis, appears as a skin rash caused by an allergic reaction to certain parasites that infect some birds and mammals. These microscopic parasites are released from infected snails into fresh and salt water (such as lakes, ponds, and oceans). While the parasite's preferred host is the specific bird or mammal, if the parasite comes into contact with a swimmer, it burrows into the skin causing an allergic reaction and rash. Swimmer's itch is found throughout the world and is more frequent during summer months. Most cases of swimmer's itch do not require medical attention.

MalaCards based summary: Cercarial Dermatitis, also known as swimmer's itch, is related to urinary schistosomiasis and intestinal schistosomiasis. An important gene associated with Cercarial Dermatitis is CTSZ (Cathepsin Z), and among its related pathways/superpathways are Inflammatory response pathway and Development and heterogeneity of the ILC family. Affiliated tissues include skin, breast and liver.

Disease Ontology: ¹¹ A schistosomiasis that is a short-term, cutaneous inflammatory response associated with penetration of the skin by cercariae of bird schistosome, Austrobilharzia variglandis. The disease has symptom skin reddening, has symptom skin itching, in the water or immediately after emerging and has symptom itchy, raised papules, occur within hours of infection.

GARD: ¹⁹ An unusual presentation of schistosomiasis characterized by a pruritic papular rash in the perigenital or periumbilical area due to an allergic reaction to schistosoma eggs deposited in the skin.

Wikipedia: ⁷⁵ Swimmer's itch, cercarial dermatitis or schistosome dermatitis is a short-term allergic contact... more...

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Related Diseases for Cercarial Dermatitis

Diseases related to Cercarial Dermatitis via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 124)

#	Related Disease	Score	Top Affiliating Genes
1	urinary schistosomiasis	30.1	SNAI1 IL5 IL4
2	intestinal schistosomiasis	29.8	SNAI1 MT-CO1 IL5 IL4
3	erythema multiforme	29.4	IL5 IL4
4	dermatitis	11.0
5	schistosomiasis	10.7
6	exanthem	10.4
7	allergic disease	10.3
8	skin disease	10.3
9	trench fever	10.3	MT-TW MT-CO1
10	diphyllobothriasis	10.2	MT-ND5 MT-CO1
11	coenurosis	10.2	MT-ND5 MT-CO1
12	sparganosis	10.2	MT-ND5 MT-CO1
13	mitochondrial myopathy, infantile, transient	10.2	MT-ND5 MT-CO1
14	myiasis	10.2	MT-ND5 MT-CO1
15	mitochondrial dna-associated leigh syndrome	10.2	MT-TW MT-ND5
16	bartonellosis	10.2	MT-TC MT-CO1
17	norwegian scabies	10.2	MT-CO1 IL5
18	angiostrongyliasis	10.2	MT-CO1 IL5
19	gnathomiasis	10.2	MT-CO1 MT-ATP8
20	parkinson disease, late-onset	10.2
21	chronic meningitis	10.2	MT-CO1 IL5
22	paragonimiasis	10.2	MT-CO1 IL5
23	uveal coloboma-cleft lip and palate-intellectual disability	10.1	MT-ND5 MT-ATP8
24	tick infestation	10.1	MT-CO1 IL4
25	elephantiasis	10.1	IL5 IL4
26	chromium allergic contact dermatitis	10.1	IL5 IL4
27	persistent severe asthma	10.1	IL5 IL4
28	neurodegeneration with brain iron accumulation 2a	10.1
29	diffuse idiopathic skeletal hyperostosis	10.1
30	thunderstorm triggered asthma	10.1	IL5 IL4
31	papillary conjunctivitis	10.1	IL5 IL4
32	cough variant asthma	10.1	IL5 IL4
33	scabies	10.1	IL5 IL4
34	near-fatal asthma	10.1	IL5 IL4
35	t2-low asthma	10.1	IL5 IL4
36	cow milk allergy	10.1	IL5 IL4
37	milk allergy	10.1	IL5 IL4
38	kimura disease	10.1	IL5 IL4
39	nut allergy	10.0	IL5 IL4
40	loiasis	10.0	IL5 IL4
41	metal allergy	10.0	IL5 IL4
42	intellectual developmental disorder, autosomal dominant 30, with speech delay and behavioral abnormalities	10.0	MT-TC MT-ATP8
43	mikulicz disease	10.0	IL5 IL4
44	t2-high asthma	10.0	IL5 IL4
45	adenoid hypertrophy	10.0	IL5 IL4
46	ascaris lumbricoides infection	10.0	IL5 IL4
47	trichinosis	10.0	IL5 IL4
48	intermittent asthma	10.0	IL5 IL4
49	vasomotor rhinitis	10.0	IL5 IL4
50	giant papillary conjunctivitis	10.0	IL5 IL4

Graphical network of the top 20 diseases related to Cercarial Dermatitis:

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Symptoms & Phenotypes for Cercarial Dermatitis

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Drugs & Therapeutics for Cercarial Dermatitis

Search Clinical Trials, NIH Clinical Center for Cercarial Dermatitis

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Genetic Tests for Cercarial Dermatitis

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Anatomical Context for Cercarial Dermatitis

Organs/tissues related to Cercarial Dermatitis:

MalaCards : Skin, Breast, Liver

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Publications for Cercarial Dermatitis

Articles related to Cercarial Dermatitis:

(show top 50) (show all 305)

#	Title	Authors	PMID	Year
1	A novel schistosome species hosted by Planorbella (Helisoma) trivolvis is the most widespread swimmer's itch-causing parasite in Michigan inland lakes. ⁶²	Soper DM...Hanington PC	36349562	2022
2	A putative new genus of avian schistosome transmitted by Biomphalaria straminea (Gastropoda: Planorbidae) in Brazil, with a discussion on the potential involvement in human cercarial dermatitis. ⁶²	Pinto HA...Brant SV	35659634	2022
3	A report of Bilharziella polonica cercariae in Knowsley Safari, Prescot, United Kingdom, with notes on other trematodes implicated in human cercarial dermatitis. ⁶²	Juhasz A...Stothard JR	36305615	2022
4	Mammalian and Avian Larval Schistosomatids in Bangladesh: Molecular Characterization, Epidemiology, Molluscan Vectors, and Occurrence of Human Cercarial Dermatitis. ⁶²	Labony SS...Anisuzzaman	36297270	2022
5	Cutaneous schistosomiasis: epidemiological and clinical characteristics in returning travelers. ⁶²	Iriarte C...Marks DH	36096120	2022
6	Schistosomes in the Persian Gulf: novel molecular data, host associations, and life-cycle elucidations. ⁶²	Khosravi M...Georgieva S	35931886	2022
7	Threat of cercarial dermatitis in Hungary: A first report of Trichobilharzia franki from the mallard (Anas platyrhynchos) and European ear snail (Radix auricularia) using molecular methods. ⁶²	Juhasz A...Cech G	35572039	2022
8	Cercariae of a Bird Schistosome Follow a Similar Emergence Pattern under Different Subarctic Conditions: First Experimental Study. ⁶²	Soldanova M...Scholz T	35745501	2022
9	The Tails of Two Avian Schistosomes: Paired Exposure Study Demonstrates Trichobilharzia stagnicolae Penetrates Human Skin More Readily than a Novel Avian Schistosome from Planorbella. ⁶²	Anderson NJ...DeJong RJ	35745505	2022
10	Simplifying Schistosome Surveillance: Using Molecular Cercariometry to Detect and Quantify Cercariae in Water. ⁶²	McPhail BA...Hanington PC	35631086	2022
11	Scratching the Itch: Updated Perspectives on the Schistosomes Responsible for Swimmer's Itch around the World. ⁶²	Loker ES...Brant SV	35631108	2022
12	Non-resident definitive host presence is sufficient to sustain avian schistosome populations. ⁶²	Rudko SP...Hanington PC	35007566	2022
13	Diversity of Trichobilharzia in New Zealand with a new species and a redescription, and their likely contribution to cercarial dermatitis. ⁶²	Davis NE...Brant SV	35264267	2022
14	Morphological, Behavioral, and Molecular Characterization of Avian Schistosomes (Digenea: Schistosomatidae) in the Native Snail Chilina dombeyana (Chilinidae) from Southern Chile. ⁶²	Oyarzun-Ruiz P...Moreno L	35335656	2022
15	Chinkui dermatitis: the sea bather's eruption. ⁶²	Odagawa S...Yoshida M	34791435	2022
16	Non-coding Regions of Mitochondrial DNA and the cox1 Gene Reveal Genetic Variability Among Local Belarusian Populations of the Causative Agent of Cercarial Dermatitis, Bird Schistosome Trichobilharzia szidati (Digenea: Schistosomatidae). ⁶²	Chrisanfova G...Semyenova S	33860433	2021
17	First Record of Trichobilharzia physellae (Talbot, 1936) in Europe, a Possible Causative Agent of Cercarial Dermatitis. ⁶²	Helmer N...Haring E	34832628	2021
18	Parasitological and molecular characterization of the avian schistosomatid cercariae infecting lymnaeidae snails in Phayao, Northern Thailand. ⁶²	Japa O...Phuangsri C	34903922	2021
19	Pruritic zosteriform papules of the trunk: a rare manifestation of late cutaneous schistosomiasis. ⁶²	Steinmayer L...Samimi M	33817776	2021
20	Invaders as Diluents of the Cercarial Dermatitis Etiological Agent. ⁶²	Stanicka A...Zbikowska E	34208370	2021
21	Association between human cercarial dermatitis (HCD) and the occurrence of Trichibilarizia in duck and snail in main wetlands from Mazandaran Province, northern Iran. ⁶²	Kia Lashaki E...Daryani A	33898795	2021
22	Cercarial Dermatitis at Public Bathing Sites (Region Zealand, Denmark): A Case Series and Literature Review. ⁶²	Al-Jubury A...Buchmann K	34413733	2021
23	Dermatological and Molecular Evidence of Human Cercarial Dermatitis in North-Eastern Poland. ⁶²	Korycinska J...Dzika E	33566721	2021
24	Avian schistosome species in Danish freshwater lakes: relation to biotic and abiotic factors. ⁶²	Al-Jubury A...Buchmann K	33875029	2021
25	Schistosomiasis in Norwegian students after travel to Africa. ⁶²	Kristiansen T...Morch K	33624965	2021
26	Migratory routes, domesticated birds and cercarial dermatitis: the distribution of Trichobilharzia franki in Northern Iran. ⁶²	Ashrafi K...Brant SV	33433322	2021
27	Evidence of a Putative Novel Species of Avian Schistosome Infecting Planorbella trivolvis. ⁶²	McPhail BA...Hanington PC	33556182	2021
28	[Vulva bilharzia in a 10-year-old girl living in Kirane-Mali: a case report]. ⁶²	Keita BS...Dao S	34178230	2021
29	Descriptive Pathological Study of Avian Schistosomes Infection in Whooper Swans (Cygnus cygnus) in Japan. ⁶²	Ahmed MS...Elmahallawy EK	33321808	2020
30	First confirmed record of Trichobilharzia franki Müller & Kimmig, 1994, from Radix auricularia (Linnaeus, 1758) for Austria. ⁶²	Reier S...Sattmann H	33150513	2020
31	Temperature and light effects on Trichobilharzia szidati cercariae with implications for a risk analysis. ⁶²	Al-Jubury A...Buchmann K	32933558	2020
32	Confirmation of the presence of zoonotic Trichobilharzia franki following a human cercarial dermatitis outbreak in recreational water in Slovakia. ⁶²	Gulyas K...Oros M	32562067	2020
33	Nitric oxide debilitates the neuropathogenic schistosome Trichobilharzia regenti in mice, partly by inhibiting its vital peptidases. ⁶²	Machacek T...Horak P	32819437	2020
34	Global prevalence status of avian schistosomes: A systematic review with meta-analysis. ⁶²	Lashaki EK...Dodangeh S	32181379	2020
35	Direct onshore wind predicts daily swimmer's itch (avian schistosome) incidence at a Michigan beach. ⁶²	Sckrabulis JP...Raffel TR	31965949	2020
36	Snail defence responses to parasite infection: The Lymnaea stagnalis-Trichobilharzia szidati model. ⁶²	Skala V...Horak P	31402190	2020
37	The chemotactic swimming behavior of bird schistosome miracidia in the presence of compatible and incompatible snail hosts. ⁶²	Marszewska A...Zbikowska E	32742786	2020
38	Outbreak of Swimmer's Itch in Denmark. ⁶²	Tracz ES...Bygum A	31453626	2019
39	Cutaneous schistosomiasis and leishmaniasis coinfection: a case report. ⁶²	Gregorio AW...Tomimori J	30801816	2019
40	Species-specific qPCR assays allow for high-resolution population assessment of four species avian schistosome that cause swimmer's itch in recreational lakes. ⁶²	Rudko SP...Hanington PC	31061794	2019
41	Outbreak of swimmer's itch in Central Italy: Description, causative agent and preventive measures. ⁶²	De Liberato C...Scaramozzino P	30784198	2019
42	Evaluation of targeted copper sulfate (CuSO4) application for controlling swimmer's itch at a freshwater recreation site in Michigan. ⁶²	Froelich KL...Hanington PC	30850865	2019
43	Freshwater snails as the intermediate host of trematodes in Iran: a systematic review. ⁶²	Dodangeh S...Sarvi S	30754962	2019
44	Thermal preferences of bird schistosome snail hosts increase the risk of swimmer's itch. ⁶²	Zbikowska E...Marszewska A	30509640	2018
45	Cercarial dermatitis: a systematic follow-up study of human cases with implications for diagnostics. ⁶²	Machacek T...Mikes L	30302587	2018
46	Genetic diversity of an avian nasal schistosome causing cercarial dermatitis in the Black Sea-Mediterranean migratory route. ⁶²	Ashrafi K...Brant SV	30343420	2018
47	Use of qPCR-Based Cercariometry to Assess Swimmer's Itch in Recreational Lakes. ⁶²	Rudko SP...Hanington PC	30120669	2018
48	Agents of swimmer's itch-dangerous minority in the Digenea invasion of Lymnaeidae in water bodies and the first report of Trichobilharzia regenti in Poland. ⁶²	Marszewska A...Zbikowska E	30215139	2018
49	Swimmer's itch in Canada: a look at the past and a survey of the present to plan for the future. ⁶²	Gordy MA...Hanington PC	30359259	2018
50	Some facts on south asian schistosomiasis and need for international collaboration. ⁶²	Agrawal MC...Rao VG	29273443	2018

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Genes for Cercarial Dermatitis

Genes related to Cercarial Dermatitis (0 elite genes):

(show all 13)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	CTSZ	Cathepsin Z	Protein Coding	6.2	DISEASES inferred ¹⁴
2	MT-CO1	Mitochondrially Encoded Cytochrome C Oxidase I	Protein Coding	5.97	DISEASES inferred ¹⁴
3	MIR3668	MicroRNA 3668	RNA Gene	5.3	DISEASES inferred ¹⁴
4	SNAI1	Snail Family Transcriptional Repressor 1	Protein Coding	4.91	DISEASES inferred ¹⁴
5	MT-TW	Mitochondrially Encoded TRNA-Trp (UGA/G)	RNA Gene	4.83	DISEASES inferred ¹⁴
6	SULT4A1	Sulfotransferase Family 4A Member 1	Protein Coding	4.82	DISEASES inferred ¹⁴
7	MT-ND5	Mitochondrially Encoded NADH:Ubiquinone Oxidoreductase Core Subunit 5	Protein Coding	4.72	DISEASES inferred ¹⁴
8	MT-TC	Mitochondrially Encoded TRNA-Cys (UGU/C)	RNA Gene	4.65	DISEASES inferred ¹⁴
9	IL5	Interleukin 5	Protein Coding	4.61	DISEASES inferred ¹⁴
10	IL4	Interleukin 4	Protein Coding	4.56	DISEASES inferred ¹⁴
11	EDDM3B	Epididymal Protein 3B	Protein Coding	4.48	DISEASES inferred ¹⁴
12	CTSB	Cathepsin B	Protein Coding	4.43	DISEASES inferred ¹⁴
13	MT-ATP8	Mitochondrially Encoded ATP Synthase Membrane Subunit 8	Protein Coding	4.42	DISEASES inferred ¹⁴

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Variations for Cercarial Dermatitis

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Expression for Cercarial Dermatitis

Search GEO for disease gene expression data for Cercarial Dermatitis.

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Pathways for Cercarial Dermatitis

Pathways related to Cercarial Dermatitis according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Inflammatory response pathway ⁷⁴	10.89	IL5 IL4
2	Development and heterogeneity of the ILC family ⁷⁴	10.83	IL5 IL4
3	Cytokines and inflammatory response ⁷⁴	10.72	IL5 IL4
4	Immune infiltration in pancreatic cancer ⁷⁴	10.59	IL5 IL4
5	OX40 Pathway ⁶⁴	10.37	IL5 IL4
6	IL-9 Signaling and its Primary Biological Effects in Different Immune Cell Types ⁶⁵	9.7	IL5 IL4

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GO Terms for Cercarial Dermatitis

Biological processes related to Cercarial Dermatitis according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	electron transport coupled proton transport	GO:0015990	8.92	MT-ND5 MT-CO1

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Sources for Cercarial Dermatitis

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: CRC001 MIFTS: 32	Cercarial Dermatitis Categories: Immune diseases, Infectious diseases, Rare diseases, Skin diseases	Data Licensing For inquiries, contact: [email protected]
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