MCID: CRB026
MIFTS: 33

Cerebellar Astrocytoma

Categories: Bone diseases, Cancer diseases, Neuronal diseases

Aliases & Classifications for Cerebellar Astrocytoma

MalaCards integrated aliases for Cerebellar Astrocytoma:

Name: Cerebellar Astrocytoma 12 15 71
Astrocytoma of Cerebellum 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4848
NCIt 50 C9475
UMLS 71 C0740480

Summaries for Cerebellar Astrocytoma

MalaCards based summary : Cerebellar Astrocytoma, also known as astrocytoma of cerebellum, is related to malignant astrocytoma and pilocytic astrocytoma. An important gene associated with Cerebellar Astrocytoma is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are Innate Immune System and Oncogenic MAPK signaling. The drugs Melphalan and Sargramostim have been mentioned in the context of this disorder. Affiliated tissues include cerebellum, liver and bone marrow, and related phenotypes are Decreased shRNA abundance (Z-score < -2) and Decreased shRNA abundance (Z-score < -2)

Related Diseases for Cerebellar Astrocytoma

Diseases related to Cerebellar Astrocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 129)
# Related Disease Score Top Affiliating Genes
1 malignant astrocytoma 30.9 SERPINA3 NF1 KIAA1549 IDH1 BRAF
2 pilocytic astrocytoma 30.4 NF1 KIAA1549 IDH1 BRAF
3 juvenile pilocytic astrocytoma 30.3 NF1 KIAA1549 IDH1
4 benign ependymoma 29.9 NF1 KIAA1549 IDH1
5 astroblastoma 29.8 IDH1 BRAF
6 glioma 29.7 NF1 IDH1 H3C11 BRAF
7 juvenile astrocytoma 29.6 KIAA1549 IDH1 FAM131B BRAF
8 diffuse astrocytoma 29.5 NF1 KIAA1549 IDH1 FAM131B BRAF
9 pilocytic astrocytoma of cerebellum 26.7 RNF130 PASD1 NF1 MKRN1 KIAA1549 IDH1
10 childhood cerebellar astrocytic neoplasm 11.2
11 cerebellar astrocytoma, childhood 11.1
12 glioma susceptibility 1 10.9
13 medulloblastoma 10.3
14 hydrocephalus 10.3
15 peripheral nerve schwannoma 10.3 SERPINA3 NF1
16 spinal cord astrocytoma 10.2 KIAA1549 IDH1
17 childhood oligodendroglioma 10.2 KIAA1549 IDH1
18 malignant spindle cell melanoma 10.2 SERPINA3 NF1
19 adult astrocytic tumour 10.2 KIAA1549 IDH1
20 chondroblastic osteosarcoma 10.2 SERPINA3 IDH1
21 giant cell reparative granuloma 10.2 SERPINA3 NF1
22 spinal cord oligodendroglioma 10.2 NF1 IDH1
23 adult xanthogranuloma 10.2 SERPINA3 NF1
24 spinal cord glioma 10.2 KIAA1549 IDH1
25 pathologic nystagmus 10.2
26 mixed glioma 10.2 NF1 IDH1
27 syringocystadenoma papilliferum 10.2 SERPINA3 BRAF
28 subependymal glioma 10.2 NF1 KIAA1549
29 urachal adenocarcinoma 10.2 NF1 BRAF
30 high grade ependymoma 10.1 KIAA1549 IDH1
31 persistent generalized lymphadenopathy 10.1 SERPINA3 NF1
32 optic nerve neoplasm 10.1 NF1 KIAA1549 FAM131B
33 pulmonic stenosis 10.1 NF1 BRAF
34 juvenile xanthogranuloma 10.1 SERPINA3 BRAF
35 erdheim-chester disease 10.1 SERPINA3 BRAF
36 dysembryoplastic neuroepithelial tumor 10.1 KIAA1549 IDH1 FAM131B
37 supratentorial cancer 10.1 KIAA1549 IDH1
38 gliofibroma 10.1 NF1 KIAA1549 IDH1
39 spinal cancer 10.1 NF1 KIAA1549 IDH1
40 nervous system cancer 10.1 SERPINA3 NF1 IDH1
41 glial tumor 10.1
42 ossifying fibroma 10.1 SERPINA3 NF1
43 skin benign neoplasm 10.0 SERPINA3 NF1 BRAF
44 suppression of tumorigenicity 12 10.0 SERPINA3 IDH1 BRAF
45 giant cell glioblastoma 10.0 SERPINA3 IDH1 BRAF
46 branchiootic syndrome 1 10.0
47 monocular esotropia 10.0
48 anaplastic astrocytoma 10.0
49 hemangioblastoma 10.0
50 intracranial hypertension 10.0

Graphical network of the top 20 diseases related to Cerebellar Astrocytoma:



Diseases related to Cerebellar Astrocytoma

Symptoms & Phenotypes for Cerebellar Astrocytoma

GenomeRNAi Phenotypes related to Cerebellar Astrocytoma according to GeneCards Suite gene sharing:

26 (show all 21)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased shRNA abundance (Z-score < -2) GR00366-A-110 9.64 BRAF
2 Decreased shRNA abundance (Z-score < -2) GR00366-A-130 9.64 H3C11
3 Decreased shRNA abundance (Z-score < -2) GR00366-A-149 9.64 FAM131B
4 Decreased shRNA abundance (Z-score < -2) GR00366-A-152 9.64 FAM131B
5 Decreased shRNA abundance (Z-score < -2) GR00366-A-159 9.64 H3C11
6 Decreased shRNA abundance (Z-score < -2) GR00366-A-160 9.64 H3C11
7 Decreased shRNA abundance (Z-score < -2) GR00366-A-166 9.64 BRAF
8 Decreased shRNA abundance (Z-score < -2) GR00366-A-177 9.64 BRAF
9 Decreased shRNA abundance (Z-score < -2) GR00366-A-187 9.64 H3C11
10 Decreased shRNA abundance (Z-score < -2) GR00366-A-194 9.64 BRAF
11 Decreased shRNA abundance (Z-score < -2) GR00366-A-29 9.64 BRAF
12 Decreased shRNA abundance (Z-score < -2) GR00366-A-31 9.64 BRAF
13 Decreased shRNA abundance (Z-score < -2) GR00366-A-32 9.64 BRAF
14 Decreased shRNA abundance (Z-score < -2) GR00366-A-34 9.64 H3C11
15 Decreased shRNA abundance (Z-score < -2) GR00366-A-36 9.64 FAM131B
16 Decreased shRNA abundance (Z-score < -2) GR00366-A-46 9.64 FAM131B
17 Decreased shRNA abundance (Z-score < -2) GR00366-A-67 9.64 H3C11
18 Decreased shRNA abundance (Z-score < -2) GR00366-A-7 9.64 FAM131B
19 Decreased shRNA abundance (Z-score < -2) GR00366-A-72 9.64 BRAF
20 Decreased shRNA abundance (Z-score < -2) GR00366-A-83 9.64 FAM131B
21 Decreased shRNA abundance (Z-score < -2) GR00366-A-97 9.64 NF1

Drugs & Therapeutics for Cerebellar Astrocytoma

Drugs for Cerebellar Astrocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 14)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Melphalan Approved Phase 1 148-82-3 4053 460612
2
Sargramostim Approved, Investigational Phase 1 123774-72-1, 83869-56-1
3
Lenograstim Approved, Investigational Phase 1 135968-09-1
4
Amifostine Approved, Investigational Phase 1 20537-88-6 2141
5
Busulfan Approved, Investigational Phase 1 55-98-1 2478
6
Thiotepa Approved, Investigational Phase 1 52-24-4 5453
7 Molgramostim Investigational Phase 1 99283-10-0
8 Protective Agents Phase 1
9 Radiation-Protective Agents Phase 1
10 Liver Extracts Phase 1
11 Immunosuppressive Agents Phase 1
12 Adjuvants, Immunologic Phase 1
13 Immunologic Factors Phase 1
14 Alkylating Agents Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cilengitide (EMD 121974) (IND# 59073) in Recurrent or Progressive and Refractory Childhood High-Grade Glioma Completed NCT00679354 Phase 2 cilengitide
2 A Phase I Study of the Chemoprotectant Amifostine With Autologous Stem Cell Transplantation for High Risk or Relapsed Pediatric Solid Tumors and Brain Tumors Terminated NCT00003926 Phase 1 amifostine trihydrate;busulfan;filgrastim;melphalan;thiotepa

Search NIH Clinical Center for Cerebellar Astrocytoma

Genetic Tests for Cerebellar Astrocytoma

Anatomical Context for Cerebellar Astrocytoma

MalaCards organs/tissues related to Cerebellar Astrocytoma:

40
Cerebellum, Liver, Bone Marrow, Myeloid, Endothelial, Temporal Lobe, Occipital Lobe

Publications for Cerebellar Astrocytoma

Articles related to Cerebellar Astrocytoma:

(show top 50) (show all 252)
# Title Authors PMID Year
1
Medulloblastoma: Clinical presentation. 61
31494131 2021
2
Peripheral retinal neovascularization in a patient with pilocytic astrocytoma. 61
31771349 2020
3
"Cerebellar lesions after low-grade tumor resection can induce memory impairment in children, similar to that observed in patients with frontal lesions". 61
31451041 2020
4
Language Cerebro-cerebellar Reorganization in Children After Surgery of Right Cerebellar Astrocytoma: a fMRI Study. 61
31111430 2019
5
Treatment of corneal neovascularization with topical aflibercept in a case of exposure keratopathy following cerebellar astrocytoma surgery. 61
30574927 2019
6
Giant congenital melanocytic nevus associated with cerebellar astrocytoma. 61
29619995 2018
7
Improvement of visual field defects after focal resection for occipital lobe epilepsy: case report. 61
28524796 2018
8
The visuospatial functions in children after cerebellar low-grade astrocytoma surgery: A contribution to the pediatric neuropsychology of the cerebellum. 61
26638981 2017
9
Novel compound heterozygous mutations in a child with Ataxia-Telangiectasia showing unrelated cerebellar disorders. 61
27871447 2016
10
Post-operative accidental diagnosis of intra-cerebellar astrocytoma in an emergency appendicectomy case. 61
26962259 2016
11
Screening for cognitive deficits in 8 to 14-year old children with cerebellar tumors using self-report measures of executive and behavioral functioning and health-related quality of life. 61
26203065 2015
12
Pediatric cerebellar astrocytoma: a review. 61
26351221 2015
13
Intramedullary spinal glioblastoma metastasis from anaplastic astrocytoma of cerebellum: A case report and review of the literature. 61
26396627 2015
14
Long-term functional outcome of patients with cerebellar pilocytic astrocytoma surgically treated in childhood. 61
25383654 2015
15
Spontaneous Malignant Transformation of a Pilocytic Astrocytoma of Cerebellum: Case Report. 61
28503586 2015
16
Child-related characteristics predicting subsequent health-related quality of life in 8- to 14-year-old children with and without cerebellar tumors: a prospective longitudinal study. 61
26034623 2014
17
[Hyponatremia caused by SIADH following endoscopic third ventriculostomy: a case report]. 61
24698894 2014
18
Cerebellar astrocytoma presenting with headache and nystagmus in a 20-year-old male. 61
24485699 2014
19
Physical functioning in pediatric survivors of childhood posterior fossa brain tumors. 61
24305707 2014
20
The lost art of localization: Franc Ingraham's legacy in pediatric neurosurgery. 61
24073750 2013
21
Arrested growth and spontaneous tumor regression of partially resected low-grade cerebellar astrocytomas in children. 61
23632690 2013
22
Neurological morbidity of surgical resection of pediatric cerebellar astrocytomas. 61
23715810 2013
23
Neurosurgical treatment of low-grade cerebellar astrocytoma in children and adolescents: a single consecutive institutional series of 100 patients. 61
23240848 2013
24
Paediatric intra-axial posterior fossa tumours: pictorial review. 61
22977284 2013
25
Long-term follow-up of pediatric benign cerebellar astrocytomas. 61
21808215 2012
26
Spatial orientation deficit in children due to cerebellum astrocytoma pediatric tumor obtained by means of the Attentional Network Test. 61
21964389 2011
27
Long-term operative failure of endoscopic third ventriculostomy in pediatric patients: the role of cine phase-contrast MR imaging. 61
21456920 2011
28
Depressed skull fracture by a three-pin head holder: a case illustration. 61
20574740 2011
29
Posterior fossa tumors in children with neurofibromatosis type 1 (NF1). 61
20464401 2010
30
Calcified epidural hematoma in pediatric age group: A report of two cases. 61
21808510 2010
31
Factors influencing neurocognitive outcomes in young patients with benign and low-grade brain tumors treated with stereotactic conformal radiotherapy. 61
19864079 2010
32
Postoperative surveillance magnetic resonance imaging for cerebellar astrocytoma. 61
19960748 2009
33
Simultaneous conus medullaris ependymoma and cerebellar astrocytoma in the same patient. 61
19537133 2009
34
Radiation-induced cavernous hemangiomas: case report and literature review. 61
19534329 2009
35
A case of an anaplastic ependymoma with gliosarcomatous components. 61
19408092 2009
36
Outcome of children with low-grade cerebellar astrocytoma: long-term complications and quality of life. 61
18690461 2008
37
[Elderly patient with cerebellar malignant astrocytoma]. 61
18800635 2008
38
Medial temporal lobe epilepsy associated with misplacement of a ventricular shunting catheter. 61
18502644 2008
39
Differential prefrontal-like deficit in children after cerebellar astrocytoma and medulloblastoma tumor. 61
18412947 2008
40
Report of a radiation-induced leiomyosarcoma arising from the posterior neck. 61
17912075 2007
41
Long-term neuromotor speech deficits in survivors of childhood posterior fossa tumors: effects of tumor type, radiation, age at diagnosis, and survival years. 61
17715277 2007
42
Cerebellar astrocytoma presenting with precocious puberty in a girl. Case report. 61
17644924 2007
43
Hemifacial spasm as the initial manifestation of childhood cerebellar astrocytoma. 61
17070492 2006
44
Epilepsy and neuropsychologic deficit in a child with cerebellar astrocytoma. 61
16970895 2006
45
Spontaneous regression of cerebellar astrocytoma after subtotal resection. 61
16552566 2006
46
Response to chemotherapy of a radiation-induced glioblastoma multiforme. 61
16314941 2006
47
Long-term effects of transient cerebellar mutism after cerebellar astrocytoma or medulloblastoma tumor resection in childhood. 61
16155765 2006
48
Children and adolescents with chronic cerebellar lesions show no clinically relevant signs of aphasia or neglect. 61
16033937 2005
49
Behavioral and affective changes in children and adolescents with chronic cerebellar lesions. 61
15882798 2005
50
Persistent cognitive dysfunction secondary to cerebellar injury in patients treated for posterior fossa tumors in childhood. 61
15886508 2005

Variations for Cerebellar Astrocytoma

Expression for Cerebellar Astrocytoma

Search GEO for disease gene expression data for Cerebellar Astrocytoma.

Pathways for Cerebellar Astrocytoma

Pathways related to Cerebellar Astrocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
13.45 SERPINA3 RNF130 NF1 MKRN1 IDH1 H3C11
2
Show member pathways
11.15 NF1 KIAA1549 FAM131B CLCN6 BRAF
3
Show member pathways
10.89 NF1 BRAF
4 10.4 H3C11 H3C10

GO Terms for Cerebellar Astrocytoma

Biological processes related to Cerebellar Astrocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 chromatin silencing at rDNA GO:0000183 9.32 H3C11 H3C10
2 DNA replication-dependent nucleosome assembly GO:0006335 9.26 H3C11 H3C10
3 interleukin-7-mediated signaling pathway GO:0038111 9.16 H3C11 H3C10
4 telomere organization GO:0032200 8.96 H3C11 H3C10
5 regulation of gene silencing GO:0060968 8.62 H3C11 H3C10

Sources for Cerebellar Astrocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Mar-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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