MCID: CRB022
MIFTS: 39

Cerebellar Liponeurocytoma

Categories: Cancer diseases, Neuronal diseases, Rare diseases

Aliases & Classifications for Cerebellar Liponeurocytoma

MalaCards integrated aliases for Cerebellar Liponeurocytoma:

Name: Cerebellar Liponeurocytoma 12 54 60 15 17 74
Lipomatous Medulloblastoma 12
Central Neurocytoma 74

Characteristics:

Orphanet epidemiological data:

60
cerebellar liponeurocytoma
Inheritance: Not applicable; Age of onset: Adult;

Classifications:

Orphanet: 60  
Rare neurological diseases


External Ids:

Disease Ontology 12 DOID:6458
NCIt 51 C6905
UMLS via Orphanet 75 C1370507
Orphanet 60 ORPHA251931

Summaries for Cerebellar Liponeurocytoma

MalaCards based summary : Cerebellar Liponeurocytoma, also known as lipomatous medulloblastoma, is related to oligodendroglioma and medulloblastoma, and has symptoms including vomiting and headache. An important gene associated with Cerebellar Liponeurocytoma is SYP (Synaptophysin), and among its related pathways/superpathways are Glucose / Energy Metabolism and Neuroscience. The drugs Trametinib and Carboplatin have been mentioned in the context of this disorder. Related phenotypes are Decreased viability in esophageal squamous lineage and behavior/neurological

Related Diseases for Cerebellar Liponeurocytoma

Diseases related to Cerebellar Liponeurocytoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 178)
# Related Disease Score Top Affiliating Genes
1 oligodendroglioma 29.6 ENO2 GFAP IDH1 OLIG2 SYP
2 medulloblastoma 29.0 ATOH1 ENO2 GFAP IDH1 MAP2 PTCH1
3 bone benign neoplasm 10.5 ENO2 SYP
4 connective tissue benign neoplasm 10.5 ENO2 SYP
5 glomus tumor 10.5 ENO2 SYP
6 intraocular retinoblastoma 10.5 ENO2 SYP
7 meningeal melanomatosis 10.5 ENO2 SYP
8 extraskeletal ewing sarcoma 10.5 ENO2 SYP
9 papilloma of choroid plexus 10.4 GFAP SYP
10 anaplastic ependymoma 10.4 GFAP SYP
11 brain ischemia 10.4 GFAP MAP2
12 carotid body cancer 10.4 ENO2 SYP
13 hemimegalencephaly 10.4 GFAP MAP2
14 malignant sertoli cell tumor 10.4 ENO2 SYP
15 partial motor epilepsy 10.4 RBFOX3 SYP
16 granular cell tumor 10.4 ENO2 GFAP
17 sinonasal undifferentiated carcinoma 10.4 ENO2 SYP
18 pancreatic somatostatinoma 10.4 ENO2 SYP
19 cutaneous ganglioneuroma 10.4 ENO2 SYP
20 extrahepatic bile duct adenocarcinoma 10.4 ENO2 SYP
21 sensory organ benign neoplasm 10.4 ENO2 SYP
22 orbital cancer 10.4 ENO2 SYP
23 gangliocytoma 10.4 RBFOX3 SYP
24 middle ear adenoma 10.4 ENO2 SYP
25 desmoplastic infantile ganglioglioma 10.4 GFAP SYP
26 cancer-associated retinopathy 10.4 ENO2 SAG
27 rosette-forming glioneuronal tumor 10.4 MAP2 SYP
28 lung combined type small cell carcinoma 10.4 GFAP SYP
29 endometrial small cell carcinoma 10.4 ENO2 SYP
30 sella turcica neoplasm 10.4 RBFOX3 SYP
31 intracranial cysts 10.4 ENO2 GFAP
32 primitive neuroectodermal tumor of the cervix uteri 10.4 ENO2 GFAP
33 tuberculum sellae meningioma 10.3 RBFOX3 SYP
34 malignant teratoma 10.3 ENO2 SYP
35 papillary tumor of the pineal region 10.3 ENO2 MAP2 SYP
36 cerebellar medulloblastoma 10.3 ENO2 GFAP
37 epithelial-myoepithelial carcinoma 10.3 PLIN1 SMARCB1
38 plexiform schwannoma 10.3 ENO2 GFAP
39 choroid plexus cancer 10.3 GFAP SMARCB1
40 optic nerve neoplasm 10.3 ENO2 MAP2 SYP
41 panophthalmitis 10.3 SAG SYP
42 large cell carcinoma with rhabdoid phenotype 10.3 ENO2 SMARCB1
43 ependymoma 10.3 ENO2 GFAP SYP
44 chiari malformation 10.3 GFAP MAP2 SYP
45 obstructive hydrocephalus 10.3 GFAP SYP
46 central nervous system primitive neuroectodermal neoplasm 10.3 ENO2 GFAP SYP
47 clear cell ependymoma 10.3 ENO2 GFAP SYP
48 cerebral neuroblastoma 10.3 ENO2 GFAP SYP
49 subependymal glioma 10.3 ENO2 GFAP SYP
50 astroblastoma 10.3 ENO2 GFAP SYP

Graphical network of the top 20 diseases related to Cerebellar Liponeurocytoma:



Diseases related to Cerebellar Liponeurocytoma

Symptoms & Phenotypes for Cerebellar Liponeurocytoma

UMLS symptoms related to Cerebellar Liponeurocytoma:


vomiting, headache

GenomeRNAi Phenotypes related to Cerebellar Liponeurocytoma according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability in esophageal squamous lineage GR00235-A 9.28 ATOH1 CHGA FABP4 GFAP IDH1 MAP2

MGI Mouse Phenotypes related to Cerebellar Liponeurocytoma:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.02 ATOH1 ENO2 GFAP MAP2 NEUROG1 OLIG2
2 growth/size/body region MP:0005378 9.96 CHGA ENO2 FABP4 GFAP IDH1 MAP2
3 mortality/aging MP:0010768 9.85 ATOH1 CHGA FABP4 GFAP IDH1 MAP2
4 muscle MP:0005369 9.5 CHGA FABP4 GFAP OLIG2 PLIN1 PTCH1
5 nervous system MP:0003631 9.36 ATOH1 CHGA ENO2 GFAP MAP2 NEUROG1

Drugs & Therapeutics for Cerebellar Liponeurocytoma

Drugs for Cerebellar Liponeurocytoma (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 7)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Trametinib Approved Phase 2 871700-17-3 11707110
2
Carboplatin Approved Phase 2 41575-94-4 38904 10339178 498142
3
Dabrafenib Approved, Investigational Phase 2 1195765-45-7 44462760 44516822
4
Vincristine Approved, Investigational Phase 2 2068-78-2, 57-22-7 5978
5 Antimitotic Agents Phase 2
6 Protein Kinase Inhibitors Phase 2
7 Antineoplastic Agents, Phytogenic Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase II Pediatric Study With Dabrafenib in Combination With Trametinib in Patients With HGG and LGG Recruiting NCT02684058 Phase 2 dabrafenib;trametinib;Carboplatin with vincristine

Search NIH Clinical Center for Cerebellar Liponeurocytoma

Genetic Tests for Cerebellar Liponeurocytoma

Anatomical Context for Cerebellar Liponeurocytoma

Publications for Cerebellar Liponeurocytoma

Articles related to Cerebellar Liponeurocytoma:

(show all 45)
# Title Authors Year
1
Supratentorial intracerebral cerebellar liponeurocytoma: A case report and literature review. ( 29480846 )
2018
2
Cerebellar liponeurocytoma - a rare entity: a case report. ( 29908563 )
2018
3
Cerebellar Liponeurocytoma: The Dilemma of Multifocality. ( 30172975 )
2018
4
Clinical course of the untreated calcified big cerebellar liponeurocytoma. ( 30483397 )
2018
5
Cerebellar liponeurocytoma presenting as multifocal bilateral cerebellar hemispheric mass lesions. ( 28290424 )
2017
6
Cerebellar liponeurocytoma with atypical histological features - a rare example of a glioneuronal tumor. ( 28984116 )
2017
7
Cerebellar Liponeurocytoma: A Novel Report from Nigeria in a 6-Year-Old Girl, and Review of Literature. ( 27746877 )
2016
8
Cerebellar liponeurocytoma: A case report and review of the literature. ( 26893691 )
2016
9
Cerebellar Liponeurocytoma: Relevant Clinical Cytogenetic Findings. ( 27750407 )
2016
10
Cerebellar liponeurocytoma in two siblings suggests a possible familial predisposition. ( 27349466 )
2016
11
Cerebellar Liponeurocytoma, an Unusual Tumor of the Central Nervous System - Ultrastructural Examination. ( 26107691 )
2015
12
Multifocal cerebellar liponeurocytoma. ( 26598433 )
2015
13
Cerebellar liponeurocytoma: a rare intracranial tumor with possible familial predisposition. Case report. ( 26613167 )
2015
14
Findings from positron emission tomography and genetic analyses for cerebellar liponeurocytoma. ( 25527206 )
2014
15
Cerebellar liponeurocytoma with extracranial extension: case report. ( 25482258 )
2014
16
The evolution of the anaplastic cerebellar liponeurocytoma: case report and review of the literature. ( 25250652 )
2014
17
Does "cerebellar liponeurocytoma" always reflect an expected site? An unusual case with a review of the literature. ( 24729347 )
2014
18
Cerebellar liponeurocytoma: case report. ( 23158671 )
2013
19
Photoclinic. Cerebellar liponeurocytoma. ( 23432178 )
2013
20
Multifocal cerebellar liponeurocytoma. ( 24257232 )
2013
21
Cerebellar liponeurocytoma with an unusually aggressive histopathology : case report and review of the literature. ( 23115671 )
2012
22
Magnetic resonance imaging of cerebellar liponeurocytoma. A case report and review of the literature. ( 24028986 )
2012
23
Cerebellar liponeurocytoma. ( 22849747 )
2012
24
Cerebellar liponeurocytoma: an updated follow-up of a case presenting histopathological and clinically aggressive features. ( 19439854 )
2009
25
Recurrent cerebellar liponeurocytoma with supratentorial extension. ( 19831141 )
2009
26
Cerebellar liponeurocytoma. ( 19680499 )
2009
27
Cerebellar liponeurocytoma with high proliferation index: treatment options. ( 19831140 )
2009
28
Adult cerebellar liponeurocytoma with predominant pilocytic pattern and myoid differentiation. ( 17239014 )
2007
29
Cerebellar liponeurocytoma. ( 15851097 )
2005
30
Cerebellar liponeurocytoma--a case report. ( 16758783 )
2005
31
Cerebellar liponeurocytoma: morphological, immunohistochemical, and ultrastructural study of a relapsed case. ( 15822821 )
2005
32
Cerebellar liponeurocytoma/lipidized medulloblastoma. ( 15719276 )
2005
33
Problematic differential diagnosis between cerebellar liponeurocytoma and anaplastic oligodendroglioma. ( 15327238 )
2004
34
Cerebellar liponeurocytoma (lipomatous medulloblastoma). ( 12717299 )
2003
35
Cerebellar liponeurocytoma: a case report and review of the literature. ( 15080526 )
2003
36
Cerebellar liponeurocytoma with an unusually aggressive clinical course: case report. ( 14633310 )
2003
37
Lipomatous medulloblastoma: a rare adult tumor variant with a uniquely favorable prognosis. ( 14670682 )
2003
38
Cerebellar liponeurocytoma: a newly recognized clinico-pathological entity. ( 12364938 )
2002
39
Cerebellar liponeurocytoma. Case report with considerations on prognosis and management. ( 12181694 )
2002
40
Neuroimaging of cerebellar liponeurocytoma. Case report. ( 11780904 )
2001
41
Cerebellar liponeurocytoma: immunohistochemical and ultrastructural study of a case. ( 11297321 )
2001
42
Cerebellar liponeurocytoma. Case report and review of the literature. ( 11596966 )
2001
43
Medulloblastoma with lipidized cells versus lipomatous medulloblastoma. ( 11128619 )
2000
44
Lipomatous medulloblastoma. ( 9266140 )
1997
45
Lipomatous medulloblastoma in adults: a new tumor type with possible favorable prognosis. ( 8026834 )
1994

Variations for Cerebellar Liponeurocytoma

Expression for Cerebellar Liponeurocytoma

Search GEO for disease gene expression data for Cerebellar Liponeurocytoma.

Pathways for Cerebellar Liponeurocytoma

Pathways related to Cerebellar Liponeurocytoma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.95 ENO2 FABP4 IDH1 PLIN1
2 11.63 ENO2 GFAP MAP2 RBFOX3 SAG SYP
3 11.44 GFAP NEUROG1 OLIG2
4 11.15 GFAP MAP2 OLIG2 SYP

GO Terms for Cerebellar Liponeurocytoma

Cellular components related to Cerebellar Liponeurocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuronal cell body GO:0043025 9.46 ENO2 MAP2 NEUROG1 RBFOX3
2 perikaryon GO:0043204 9.13 ENO2 NEUROG1 RBFOX3
3 dendritic growth cone GO:0044294 8.62 MAP2 PTCH1

Biological processes related to Cerebellar Liponeurocytoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 neuron differentiation GO:0030182 9.33 ATOH1 NEUROG1 OLIG2
2 regulation of neuron differentiation GO:0045664 9.26 ATOH1 NEUROG1
3 nervous system development GO:0007399 9.02 ATOH1 NEUROG1 OLIG2 RBFOX3 SMARCB1
4 spinal cord motor neuron differentiation GO:0021522 8.96 OLIG2 PTCH1

Sources for Cerebellar Liponeurocytoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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