MCID: CRB028
MIFTS: 33

Cerebellar Medulloblastoma

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Cerebellar Medulloblastoma

MalaCards integrated aliases for Cerebellar Medulloblastoma:

Name: Cerebellar Medulloblastoma 12 6 15 70

Classifications:



External Ids:

Disease Ontology 12 DOID:0060104
UMLS 70 C4024934

Summaries for Cerebellar Medulloblastoma

Disease Ontology : 12 A cerebellum cancer that begins in the lower part of the brain on the floor of the skull.

MalaCards based summary : Cerebellar Medulloblastoma is related to adult medulloblastoma and hydrocephalus. An important gene associated with Cerebellar Medulloblastoma is ENO2 (Enolase 2), and among its related pathways/superpathways are Pathways in cancer and Neuroscience. Affiliated tissues include cerebellum, brain and spinal cord, and related phenotypes are nervous system and vision/eye

Related Diseases for Cerebellar Medulloblastoma

Diseases related to Cerebellar Medulloblastoma via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 233)
# Related Disease Score Top Affiliating Genes
1 adult medulloblastoma 30.1 SHH PTCH1
2 hydrocephalus 30.0 SYP PTCH1 GFAP ENO2
3 obstructive hydrocephalus 29.9 SYP GFAP ENO2
4 oligodendroglioma 29.4 SYP MSH6 GFAP ENO2
5 pineocytoma 29.3 SYP SAG GFAP ENO2
6 medulloblastoma 29.1 SYP SHH SAG PTCH1 MSH6 GLI1
7 intracranial cysts 10.3 GFAP ENO2
8 primitive neuroectodermal tumor of the cervix uteri 10.3 GFAP ENO2
9 traumatic brain injury 10.3 GFAP ENO2
10 brain injury 10.3 GFAP ENO2
11 optic nerve glioma 10.3 GFAP ENO2
12 melanotic medulloblastoma 10.3 SHH PTCH1
13 myasthenic syndrome, congenital, 3a, slow-channel 10.2 SAG CHRND
14 polydactyly, preaxial ii 10.2 SHH PTCH1
15 midline interhemispheric variant of holoprosencephaly 10.2 SHH PTCH1
16 septopreoptic holoprosencephaly 10.2 SHH PTCH1
17 holoprosencephaly 9 10.2 SHH PTCH1
18 cancer-associated retinopathy 10.2 SAG ENO2
19 optic papillitis 10.2 SAG RBP3
20 alobar holoprosencephaly 10.2 SHH PTCH1
21 lobar holoprosencephaly 10.2 SHH PTCH1
22 eales disease 10.2 SAG RBP3
23 ophthalmomyiasis 10.2 SAG RBP3
24 goblet cell carcinoid 10.2 ENO2 ATOH1
25 holoprosencephaly 11 10.2 SHH PTCH1
26 chorioretinitis 10.1 SAG RBP3
27 choroiditis 10.1 SAG RBP3
28 adult central nervous system primitive neuroectodermal neoplasm 10.1 SHH ATOH1
29 holoprosencephaly 5 10.1 SHH PTCH1
30 microform holoprosencephaly 10.1 SHH PTCH1
31 meningioma, familial 10.1
32 intracranial meningioma 10.1
33 glioblastoma 10.1
34 secretory meningioma 10.1
35 lymphoplasmacyte-rich meningioma 10.1
36 retinal vasculitis 10.1 SAG RBP3
37 li-fraumeni syndrome 10.1 SHH PTCH1 MSH6
38 myoblastoma 10.1 SYP ENO2
39 holoprosencephaly 7 10.1 SHH PTCH1
40 malignant melanocytic neoplasm of the peripheral nerve sheath 10.1 SYP ENO2
41 autoimmune disease of eyes, ear, nose and throat 10.1 SAG RBP3
42 anal neuroendocrine tumor 10.1 SYP ENO2
43 optic nerve astrocytoma 10.1 SYP ENO2
44 neuronal intestinal dysplasia, type b 10.1 SYP ENO2
45 lung meningioma 10.1 SYP ENO2
46 sinonasal undifferentiated carcinoma 10.1 SYP ENO2
47 auditory system benign neoplasm 10.1 SYP ENO2
48 papillary tumor of the pineal region 10.1 SYP ENO2
49 auditory system cancer 10.1 SYP ENO2
50 cloacogenic carcinoma 10.1 SYP ENO2

Graphical network of the top 20 diseases related to Cerebellar Medulloblastoma:



Diseases related to Cerebellar Medulloblastoma

Symptoms & Phenotypes for Cerebellar Medulloblastoma

MGI Mouse Phenotypes related to Cerebellar Medulloblastoma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 nervous system MP:0003631 9.85 ATOH1 ENO2 GFAP GLI1 PTCH1 RBP3
2 vision/eye MP:0005391 9.17 GFAP MED27 PTCH1 RBP3 SAG SHH
3 taste/olfaction MP:0005394 9.13 ENO2 PTCH1 SHH

Drugs & Therapeutics for Cerebellar Medulloblastoma

Search Clinical Trials , NIH Clinical Center for Cerebellar Medulloblastoma

Genetic Tests for Cerebellar Medulloblastoma

Anatomical Context for Cerebellar Medulloblastoma

MalaCards organs/tissues related to Cerebellar Medulloblastoma:

40
Cerebellum, Brain, Spinal Cord, Bone Marrow, Salivary Gland, Breast, Endothelial

Publications for Cerebellar Medulloblastoma

Articles related to Cerebellar Medulloblastoma:

(show top 50) (show all 285)
# Title Authors PMID Year
1
Adult Medulloblastoma Depicted With 99mTc-HYNIC-[D-Phe1, Tyr3-Octreotide] SPECT/CT. 61
33086272 2020
2
The Role of Apparent Diffusion Coefficient in the Differentiation between Cerebellar Medulloblastoma and Brainstem Glioma. 61
33137983 2020
3
A clinical case of presumed cerebellar medulloblastoma in a Japanese Black calf with increased neuron-specific enolase in cerebrospinal fluid. 61
32741886 2020
4
Ovarian cryopreservation for children aged 3 years or younger: A report of three cases. 61
32779331 2020
5
The role of diffusion tensor imaging metrics in the discrimination between cerebellar medulloblastoma and brainstem glioma. 61
32588986 2020
6
Tick-borne encephalitis virus inhibits rRNA synthesis and host protein production in human cells of neural origin. 61
31560682 2019
7
Late recurrence of medulloblastoma after 17 years of complete remission. 61
30905661 2019
8
Anatomo-functional study of the cerebellum in working memory in children treated for medulloblastoma. 61
30731145 2019
9
Clinical and magnetic resonance imaging findings of a cerebellar medulloblastoma in a heifer. 61
30656017 2019
10
Neurocognitive dysfunction in adult cerebellar medulloblastoma. 61
30315720 2019
11
Medulloblastoma in Older Adults: A Case Report and Literature Review. 61
29883827 2018
12
Subfrontal recurrence after cerebellar medulloblastoma resection without local relapse: case-based update. 61
29934705 2018
13
Medulloblastoma in association with sacral agenesis; a case report. 61
29404676 2018
14
A primitive neuroectodermal tumor in an adult: Case report of a unique location and MRI characteristics. 61
29443778 2018
15
Roseomonas mucosa bacteremia in a neutropenic child: A case report and literature review. 61
30479963 2018
16
Adult hemispheric cerebellar medulloblastoma. 61
29527392 2018
17
Cerebellar Medulloblastoma in Middle-to-Late Adulthood. 61
29651356 2018
18
Functional expression of calcium-permeable canonical transient receptor potential 4-containing channels promotes migration of medulloblastoma cells. 61
28627017 2017
19
Molecular Proteomic Characterization of a Pediatric Medulloblastoma Xenograft. 61
28647700 2017
20
Tubacin, an HDAC6 Selective Inhibitor, Reduces the Replication of the Japanese Encephalitis Virus via the Decrease of Viral RNA Synthesis. 61
28468311 2017
21
Mature salivary gland rests within sonic hedgehog-positive medulloblastoma: case report and insights into the molecular genetics and embryopathology of ectopic intracranial salivary gland analogs. 61
27635979 2016
22
Incidental Finding of Cerebellar Medulloblastoma on 68Ga-DOTATATE PET/CT in a Patient With Appendiceal Carcinoid. 61
27607158 2016
23
A case of medulloblastoma in adult patient affected by anaplastic oligoastrocytoma. 61
27329275 2016
24
Extra-hepatic replication and infection of hepatitis E virus in neuronal-derived cells. 61
26891712 2016
25
A Recurrent Mosaic Mutation in SMO, Encoding the Hedgehog Signal Transducer Smoothened, Is the Major Cause of Curry-Jones Syndrome. 61
27236920 2016
26
Relapsed High-Risk Medulloblastoma: Stable Disease after Two Years of Treatment with Somatostatin Analog - Case Report. 61
26918214 2016
27
Brain Magnetic Resonance Spectroscopy Findings in the Stroke-like Migraine Attacks after Radiation Therapy (SMART) Syndrome. 61
25702932 2015
28
Bilateral Trochlear Nerve Palsy as a Consequence of Cerebellar Medulloblastoma: Clinical and Pathological Findings in a Calf. 61
26110579 2015
29
Progressive Multiple Cavernous Angiomas after Radiotherapy in a Pediatric Patient with Medulloblastoma: A Case Report. 61
26202334 2015
30
Zfx facilitates tumorigenesis caused by activation of the Hedgehog pathway. 61
25164012 2014
31
Disrupted sensorimotor synchronization, but intact rhythm discrimination, in children treated for a cerebellar medulloblastoma. 61
24864058 2014
32
[Pediatric medulloblastoma presenting as cerebellar hemorrhage: a case report]. 61
24920742 2014
33
Magnetic resonance imaging features of cerebellar vermis medulloblastoma in an adult canine patient. 61
25001666 2014
34
Plasmapheresis: Lifesaving treatment in severe cases of HELLP syndrome. 61
25489438 2014
35
Acute two-compartment low pressure hydrocephalus--a case report. 61
23715811 2013
36
Adenomatous polyposis coli gene involvement in ileal enterochromaffin cell neuroendocrine neoplasms. 61
24139208 2013
37
Occipital diploic cranial fasciitis after radiotherapy for a cerebellar medulloblastoma. 61
24116980 2013
38
Engineered knottin peptide enables noninvasive optical imaging of intracranial medulloblastoma. 61
23950221 2013
39
Acquired oculomotor nerve paresis with cyclic spasms in a young woman, a rare subtype of neuromyotonia. 61
23807462 2013
40
The impact of fluorescence guidance on spinal intradural tumour surgery. 61
23307195 2013
41
Time perception in children treated for a cerebellar medulloblastoma. 61
23063729 2013
42
Destructive radiologic development of intravascular papillary endothelial hyperplasia on skull bone. 61
22993678 2012
43
Adult medulloblastoma associated with syringomyelia: a case report. 61
23691470 2012
44
Detecting bone marrow metastasis in cerebellar medulloblastoma: value of disease surveillance with FDG-PET in this setting. 61
21921346 2011
45
Neovascularization in Purtscher's retinopathy. 61
22125405 2011
46
Sonographic appearance of a metastasis to the breast from a cerebellar medulloblastoma. 61
20544872 2010
47
Microvessel density and vascular endothelial growth factor expression as predictors of childrens' survival from cerebellar medulloblastoma. 61
19524442 2009
48
Cerebellar medulloblastoma in the elderly. 61
19118784 2009
49
Simultaneous occurrence of cerebellar medulloblastoma and pituitary adenoma: A case report. 61
18811959 2008
50
Two metachronous tumors induced by radiation therapy: case report and review of the literature. 61
18373066 2008

Variations for Cerebellar Medulloblastoma

ClinVar genetic disease variations for Cerebellar Medulloblastoma:

6
# Gene Name Type Significance ClinVarId dbSNP ID Position
1 MSH6 NM_000179.2(MSH6):c.2722G>T (p.Glu908Ter) SNV Affects 684728 rs886056144 GRCh37: 2:48027844-48027844
GRCh38: 2:47800705-47800705

Expression for Cerebellar Medulloblastoma

Search GEO for disease gene expression data for Cerebellar Medulloblastoma.

Pathways for Cerebellar Medulloblastoma

GO Terms for Cerebellar Medulloblastoma

Biological processes related to Cerebellar Medulloblastoma according to GeneCards Suite gene sharing:

(show all 14)
# Name GO ID Score Top Affiliating Genes
1 regulation of smoothened signaling pathway GO:0008589 9.54 PTCH1 GLI1
2 spinal cord motor neuron differentiation GO:0021522 9.52 SHH PTCH1
3 intermediate filament organization GO:0045109 9.51 SHH GFAP
4 smoothened signaling pathway GO:0007224 9.5 SHH PTCH1 GLI1
5 somite development GO:0061053 9.49 SHH PTCH1
6 digestive tract morphogenesis GO:0048546 9.48 SHH GLI1
7 dorsal/ventral neural tube patterning GO:0021904 9.46 SHH PTCH1
8 smooth muscle tissue development GO:0048745 9.43 SHH PTCH1
9 metanephric collecting duct development GO:0072205 9.4 SHH PTCH1
10 Bergmann glial cell differentiation GO:0060020 9.37 SHH GFAP
11 dorsal/ventral pattern formation GO:0009953 9.33 SHH PTCH1 GLI1
12 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 9.26 SHH GLI1
13 ventral midline development GO:0007418 8.96 SHH GLI1
14 prostate gland development GO:0030850 8.8 SHH PTCH1 GLI1

Molecular functions related to Cerebellar Medulloblastoma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 patched binding GO:0005113 8.62 SHH PTCH1

Sources for Cerebellar Medulloblastoma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 05-Apr-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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