MCID: CRB029
MIFTS: 39

Cerebellopontine Angle Tumor

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Cerebellopontine Angle Tumor

MalaCards integrated aliases for Cerebellopontine Angle Tumor:

Name: Cerebellopontine Angle Tumor 12 15 74
Neoplasm of the Cerebellopontine Angle 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3200
NCIt 51 C5414
UMLS 74 C0474740

Summaries for Cerebellopontine Angle Tumor

Disease Ontology : 12 A brain stem cancer that is characterized by neoplasms in the fossa located in cerebellopotine angle.

MalaCards based summary : Cerebellopontine Angle Tumor, also known as neoplasm of the cerebellopontine angle, is related to neurilemmoma and meningioma, familial. An important gene associated with Cerebellopontine Angle Tumor is SDHD (Succinate Dehydrogenase Complex Subunit D). The drugs Anti-Infective Agents and Gentamicins have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and prostate, and related phenotypes are Increased proliferation and behavior/neurological

Related Diseases for Cerebellopontine Angle Tumor

Diseases related to Cerebellopontine Angle Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 105)
# Related Disease Score Top Affiliating Genes
1 neurilemmoma 30.7 GFAP NF2 SMARCB1
2 meningioma, familial 29.7 GFAP KANTR NF2 SMARCB1 SYP
3 acoustic neuroma 11.9
4 trigeminal neuralgia 10.4
5 monosomy 22 10.4 NF2 SMARCB1
6 schwannomatosis 1 10.4 NF2 SMARCB1
7 melanotic medulloblastoma 10.4 GFAP SMARCB1
8 cerebral convexity meningioma 10.4 GFAP NF2
9 intraventricular meningioma 10.4 GFAP NF2
10 cornea cancer 10.4 GFAP NF2
11 nodular medulloblastoma 10.4 GFAP SMARCB1
12 plexiform schwannoma 10.4 GFAP NF2
13 spinal cancer 10.3 GFAP NF2
14 cerebellopontine angle meningioma 10.3 HEYL KANTR
15 desmoplastic infantile ganglioglioma 10.3 GFAP SYP
16 mixed glioma 10.3 GFAP IDH1
17 olfactory groove meningioma 10.3 NF2 SYP
18 lung combined type small cell carcinoma 10.3 GFAP SYP
19 chordoid glioma 10.3 GFAP NF2
20 extraosseous chondrosarcoma 10.3 SMARCB1 SYP
21 cellular ependymoma 10.3 GFAP SYP
22 chordoid meningioma 10.3 GFAP SYP
23 central nervous system primitive neuroectodermal neoplasm 10.3 GFAP SYP
24 atypical neurofibroma 10.3 GFAP NF2
25 clear cell ependymoma 10.3 GFAP SYP
26 chiari malformation 10.3 GFAP SYP
27 cerebral neuroblastoma 10.3 GFAP SYP
28 foramen magnum meningioma 10.3 KANTR NF2
29 subependymal glioma 10.3 GFAP SYP
30 astroblastoma 10.3 GFAP SYP
31 glioma susceptibility 1 10.3 GFAP IDH1
32 pineal gland cancer 10.3 GFAP SYP
33 carcinoid tumors, intestinal 10.3 SDHD SYP
34 malignant ependymoma 10.3 GFAP NF2
35 rhabdoid cancer 10.3 SMARCB1 SYP
36 melanotic neuroectodermal tumor 10.3 GFAP SYP
37 obstructive hydrocephalus 10.3 GFAP SYP
38 rhabdoid meningioma 10.3 GFAP NF2 SMARCB1
39 medulloepithelioma 10.3 GFAP SYP
40 pineocytoma 10.3 GFAP SYP
41 splenic artery aneurysm 10.3 PCSK1N SAA1
42 subclavian artery aneurysm 10.2 PCSK1N SAA1
43 neuroma 10.2 GFAP NF2 SMARCB1
44 fibrillary astrocytoma 10.2 GFAP IDH1
45 subependymoma 10.2 GFAP SYP
46 cerebral ventricle cancer 10.2 GFAP SMARCB1 SYP
47 pilocytic astrocytoma 10.2 GFAP IDH1
48 cerebellar liponeurocytoma 10.2 GFAP SMARCB1 SYP
49 medullomyoblastoma 10.2 GFAP SMARCB1 SYP
50 ependymoma 10.2 GFAP NF2 SYP

Graphical network of the top 20 diseases related to Cerebellopontine Angle Tumor:



Diseases related to Cerebellopontine Angle Tumor

Symptoms & Phenotypes for Cerebellopontine Angle Tumor

GenomeRNAi Phenotypes related to Cerebellopontine Angle Tumor according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased proliferation GR00094-A 8.62 NF2 SMARCB1

MGI Mouse Phenotypes related to Cerebellopontine Angle Tumor:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.17 CTSS CYP11B1 ESR2 GFAP HEYL JAG1
2 cellular MP:0005384 10.11 CTSS CYP11B1 ESR2 FKBP4 GFAP HEYL
3 growth/size/body region MP:0005378 10.1 CYP11B1 ESR2 FAM107B FKBP4 GFAP HEYL
4 cardiovascular system MP:0005385 10.06 CTSS CYP11B1 ESR2 GFAP HEYL JAG1
5 homeostasis/metabolism MP:0005376 9.93 CTSS CYP11B1 ESR2 FKBP4 GFAP IDH1
6 digestive/alimentary MP:0005381 9.87 CTSS ESR2 FKBP4 GFAP JAG1 PCSK1N
7 mortality/aging MP:0010768 9.73 CYP11B1 ESR2 FKBP4 GFAP HEYL IDH1
8 muscle MP:0005369 9.23 CTSS CYP11B1 ESR2 GFAP HEYL JAG1

Drugs & Therapeutics for Cerebellopontine Angle Tumor

Drugs for Cerebellopontine Angle Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 65)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Infective Agents Phase 4,Phase 2,Not Applicable,Early Phase 1
2 Gentamicins Phase 4,Not Applicable
3 Anti-Bacterial Agents Phase 4,Phase 2,Not Applicable,Early Phase 1
4
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
5
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
6
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
7
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
8
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
9 Antineoplastic Agents, Hormonal Phase 3
10 glucocorticoids Phase 3
11 Antiemetics Phase 3
12 Hormone Antagonists Phase 3
13 Peripheral Nervous System Agents Phase 3,Phase 2
14 Gastrointestinal Agents Phase 3
15 Hormones Phase 3
16 Methylprednisolone Acetate Phase 3
17 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
18 Anti-Inflammatory Agents Phase 3,Phase 2
19 Protective Agents Phase 3
20 Neuroprotective Agents Phase 3
21 Autonomic Agents Phase 3
22 Prednisolone acetate Phase 3
23
Bevacizumab Approved, Investigational Phase 2,Phase 1 216974-75-3
24
Sirolimus Approved, Investigational Phase 2,Early Phase 1 53123-88-9 46835353 5284616 6436030
25
Miconazole Approved, Investigational, Vet_approved Phase 2,Early Phase 1 22916-47-8 4189
26
Everolimus Approved Phase 2,Early Phase 1 159351-69-6 70789204 6442177
27
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
28
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
29
Histamine Approved, Investigational Phase 2 51-45-6 774
30
Betahistine Approved, Investigational Phase 2 5638-76-6 2366
31
Lapatinib Approved March 2007, Investigational Phase 2,Early Phase 1 231277-92-2, 388082-78-8 208908 9941095
32
Lactitol Investigational Phase 2 585-88-6, 585-86-4 493591
33 Antibodies, Monoclonal Phase 2
34 Antineoplastic Agents, Immunological Phase 2,Phase 1
35 Antibodies Phase 2
36 Immunologic Factors Phase 2,Early Phase 1
37 Angiogenesis Inhibitors Phase 2,Phase 1
38 Immunoglobulins Phase 2
39 Angiogenesis Modulating Agents Phase 2,Phase 1
40 Immunosuppressive Agents Phase 2,Early Phase 1
41 Antibiotics, Antitubercular Phase 2,Early Phase 1
42 Antifungal Agents Phase 2,Early Phase 1
43 Endostatins Phase 2 71581480
44 Protein Kinase Inhibitors Phase 2,Early Phase 1
45 Analgesics Phase 2
46 Anti-Inflammatory Agents, Non-Steroidal Phase 2
47 Analgesics, Non-Narcotic Phase 2
48 Antipyretics Phase 2
49 Fibrinolytic Agents Phase 2
50 Cyclooxygenase Inhibitors Phase 2

Interventional clinical trials:

(show top 50) (show all 61)
# Name Status NCT ID Phase Drugs
1 Gentamicin Treatment Prior to Schwannoma Surgery - Residual Function Unknown status NCT02379754 Phase 4 Gentamicins
2 Gentamicin Treatment Prior to Schwannoma Surgery - No Residual Function Recruiting NCT02415257 Phase 4 Gentamicin
3 Stereotactic Radiation in Vestibular Schwannoma Unknown status NCT01449604 Phase 3
4 Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery Completed NCT00438087 Phase 3 methylprednisolone
5 Cyberknife Radiosurgery for Patients With Neurinomas Recruiting NCT02055859 Phase 3
6 Icotinib Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Unknown status NCT02934256 Phase 2 Icotinib
7 Bevacizumab for Symptomatic Vestibular Schwannoma in Neurofibromatosis Type 2 (NF2) Completed NCT01207687 Phase 2
8 Efficacy and Safety Study of RAD001 in the Growth of the Vestibular Schwannoma(s) in Neurofibromatosis 2 (NF2) Patients Completed NCT01490476 Phase 2 RAD001
9 Endostatin Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Completed NCT02104323 Phase 2 Endostatin
10 Lapatinib Study for Children and Adults With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Completed NCT00973739 Phase 2 Lapatinib
11 Phase II Study of Everolimus (RAD001) in Children and Adults With Neurofibromatosis Type 2 Completed NCT01419639 Phase 2 Everolimus (RAD001) , Afinitor®
12 Phase II Study of the Multichannel Auditory Brain Stem Implant for Deafness Following Surgery for Neurofibromatosis 2 Completed NCT00004437 Phase 2
13 RGD PET/MRI in Sporadic Vestibular Schwannoma Recruiting NCT03393689 Phase 2 One injection of 68Ga-NODAGA-E[c(RGDyK)]2
14 Hearing Outcomes Using Fractionated Proton Radiation Therapy for Vestibular Schwannoma Recruiting NCT01199978 Phase 2
15 Study of Aspirin in Patients With Vestibular Schwannoma Recruiting NCT03079999 Phase 2 Aspirin;Placebo
16 Trial of Selumetinib in Patients With Neurofibromatosis Type II Related Tumors Recruiting NCT03095248 Phase 2 Selumetinib
17 Phase 2 Study of Bevacizumab in Children and Young Adults With NF 2 and Progressive Vestibular Schwannomas Active, not recruiting NCT01767792 Phase 2 Bevacizumab
18 Study of RAD001 for Treatment of NF2-related Vestibular Schwannoma Active, not recruiting NCT01345136 Phase 2 RAD001, everolimus
19 Study of Axitinib in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas Active, not recruiting NCT02129647 Phase 2 Axitinib
20 AZD2014 In NF2 Patients With Progressive or Symptomatic Meningiomas Active, not recruiting NCT02831257 Phase 2 AZD2014
21 AM-125 in the Treatment of Acute Peripheral Vertigo Following Vestibular Schwannoma Resection Not yet recruiting NCT03908567 Phase 2 Intranasal Drug;Oral Tablet
22 A Study of Nilotinib in Growing Vestibular Schwannomas Terminated NCT01201538 Phase 2 Nilotinib
23 Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Vestibular Schwannoma Suspended NCT01083966 Phase 1 Bevacizumab (Avastin)
24 Vestibular Schwannoma and Psychological Factors Unknown status NCT01743248
25 Preoperative Vestibular Rehabilitation Effectiveness After Vestibular Schwannoma Surgery Unknown status NCT02275325 Not Applicable
26 Response Prediction After GKS in Patients With Vestibular Schwannoma Using DCE MR Imaging Unknown status NCT03097822
27 Effect of Implant Position on Magnetic Resonance Image Distortion Unknown status NCT02246231 Not Applicable
28 Taste Disorders in Middle Ear Disease and After Middle Ear Surgery Unknown status NCT01584011
29 Role of Psychiatric Profile in Prehabituated Patients After Vestibular Schwannoma Surgery Completed NCT03638310 Not Applicable
30 Vestibular Evaluation After Vestibular Schwannoma Treatment Completed NCT03670589
31 Vertigo Perception and Quality of Life in Patients After Surgical Treatment of Vestibular Schwannoma Completed NCT02963896 Not Applicable gentamicin
32 Concentration and Activity of Lapatinib in Vestibular Schwannomas Completed NCT00863122 Early Phase 1 lapatinib
33 WES of NF2-associated in Comparison to Sporadic Vestibular Schwannomas - Correlation With Clinical Data Completed NCT03210285
34 Cochlear Implantation After Labyrinthectomy or a Translabyrinthine Surgical Approach Completed NCT02309099 Not Applicable
35 Using Positron Emission Tomography to Predict Intracranial Tumor Growth in Neurofibromatosis Type II Patients Completed NCT01222728
36 Recovery of Visual Acuity in People With Vestibular Deficits Completed NCT00411216 Not Applicable
37 Resiliency Training for Patients With NF2 Via Videoconferencing With Skype Completed NCT02811718 Not Applicable
38 A Case-Referent Study of Brain Tumors in Adults Completed NCT00339300
39 A Family Study of Adults With Glioma Completed NCT00339352
40 Vasopressin and V2 Receptor in Meniere's Disease Completed NCT00599560 Not Applicable
41 Vestibular Outcomes in Vestibular Schwannoma Recruiting NCT03346889
42 Secondary Endolymphatic Hydrops and Vestibular Schwannomas on 3 Tesla MRI Recruiting NCT03593577
43 Simultaneous Cochlear Implantation During Translabyrinthine Resection of Vestibular Schwannoma Recruiting NCT03958006 Not Applicable
44 Simultaneous Translabyrinthine Surgery of Vestibular Schwannoma and Cochlear Implantation With Intraoperative eBERA and Correlation to Hearing Results Recruiting NCT03745560
45 Auditory Nerve Monitoring Using Intra-cochlear Stimulation in Subjects With Acoustic Neuroma Recruiting NCT02948790 Not Applicable
46 CI Following VS Removal or Labyrinthectomy Recruiting NCT03795675 Not Applicable
47 Cochlear Implantation After Gamma Knife Radiosurgery With eABR and Correlation to Postoperative Hearing Results - a Pilot Study Recruiting NCT03745534
48 Consequence of Unilateral Vestibular Loss on Visual Abilities Recruiting NCT03581331 Not Applicable
49 Protocol for Evaluating a Planning Algorithm for Gamma Knife Radiosurgery Recruiting NCT03520829
50 Maintaining Cochlear Patency After VIIIth Nerve Surgery Recruiting NCT03261726 Not Applicable

Search NIH Clinical Center for Cerebellopontine Angle Tumor

Genetic Tests for Cerebellopontine Angle Tumor

Anatomical Context for Cerebellopontine Angle Tumor

MalaCards organs/tissues related to Cerebellopontine Angle Tumor:

42
Brain, Testes, Prostate, Salivary Gland, Lung, Spinal Cord, Pineal

The Foundational Model of Anatomy Ontology organs/tissues related to Cerebellopontine Angle Tumor:

20
Cerebellopotine Angle

Publications for Cerebellopontine Angle Tumor

Articles related to Cerebellopontine Angle Tumor:

(show top 50) (show all 56)
# Title Authors Year
1
Evaluation of balance after surgery for cerebellopontine angle tumor. ( 30248037 )
2019
2
Securing Endotracheal Tube in a Bearded Patient Undergoing Surgery for Cerebellopontine Angle Tumor in Lateral Position-A Different Approach. ( 31022076 )
2019
3
The relation between flocculus volume and tinnitus after cerebellopontine angle tumor surgery. ( 29398141 )
2018
4
Glioneuronal Heterotopia Presenting as Cerebellopontine Angle Tumor of Cranial Nerve VIII. ( 29625310 )
2018
5
Petrous Apex Pneumatization: Influence on Postoperative Cerebellopontine Angle Tumor Cerebrospinal Fluid Fistula. ( 29925246 )
2018
6
Spontaneously Resolving Symptomatic Subdural Hygromas After Cerebellopontine Angle Tumor Surgery. ( 29101072 )
2018
7
Focal hyperintensity in the dorsal brain stem of patients with cerebellopontine angle tumor: A high-resolution 3 T MRI study. ( 29343821 )
2018
8
Trigeminal Ganglioneuroma: A Rare Case of Trigeminal Neuralgia Caused by Cerebellopontine Angle Tumor. ( 28043883 )
2017
9
Early Nerve Grafting for Facial Paralysis After Cerebellopontine Angle Tumor Resection With Preserved Facial Nerve Continuity. ( 26584060 )
2016
10
Bilaterally Abnormal Head Impulse Tests Indicate a Large Cerebellopontine Angle Tumor. ( 26754780 )
2016
11
Effect of corticosteroids on facial function after cerebellopontine angle tumor removal: a double-blind study versus placebo. ( 25924803 )
2015
12
Clinical use of skull tap vestibular evoked myogenic potentials for the diagnoses of the cerebellopontine angle tumor patients. ( 24804198 )
2014
13
Bruns nystagmus in cerebellopontine angle tumor. ( 23552728 )
2013
14
A 68-year old man with a cerebellopontine angle tumor. ( 23936919 )
2013
15
Transient cardiac asystole induced by electrocautery during excision of a cerebellopontine angle tumor. ( 24262476 )
2013
16
Necrotizing meningoencephalitis mimicking cerebellopontine angle tumor as late complication following cochlear implantation. ( 22340754 )
2012
17
Retrosigmoid approach to cerebellopontine angle tumor resection: surgical modifications. ( 22815095 )
2012
18
Intraoperative Transcranial Motor-Evoked Potential Monitoring of the Facial Nerve during Cerebellopontine Angle Tumor Resection. ( 24083121 )
2012
19
Early complications and symptoms of cerebellopontine angle tumor surgery: a prospective analysis. ( 21373897 )
2011
20
A 47-year old male with a cerebellopontine angle tumor. ( 19744047 )
2009
21
Concurrent vestibular schwannoma and meningioma mimicking a single cerebellopontine angle tumor. ( 20436847 )
2009
22
Brain stem candidiasis mimicking cerebellopontine angle tumor. ( 18313733 )
2008
23
Chemical meningitis following cerebellopontine angle tumor surgery. ( 18312887 )
2008
24
Cerebellopontine angle tumor in a patient with a maternally inherited SDHD gene mutation. ( 19205158 )
2008
25
Intraoperative monitoring of hearing during cerebellopontine angle tumor surgery using transtympanic electrocochleography. ( 17529854 )
2007
26
Hyperventilation-induced nystagmus in peripheral vestibulopathy and cerebellopontine angle tumor. ( 17785675 )
2007
27
Bilateral sudden sensorineural hearing loss as a presentation of metastatic adenocarcinoma of unknown primary mimicking cerebellopontine angle tumor on the magnetic resonance image. ( 16500481 )
2006
28
Unresponsiveness and pinpoint pupils after cerebellopontine angle tumor resection: opioid overdose versus postoperative hemorrhage. ( 16861457 )
2006
29
Clinicoradiological review: symptomatic superior cerebellar artery aneurysm imitating cerebellopontine angle tumor. ( 15792523 )
2005
30
Approach design and closure techniques to minimize cerebrospinal fluid leak after cerebellopontine angle tumor surgery. ( 16272937 )
2005
31
Distal anterior inferior cerebellar artery aneurysm masquerading as a cerebellopontine angle tumor: case report and review of literature. ( 16145591 )
2004
32
Preoperative versus postoperative role of vestibular-evoked myogenic potentials in cerebellopontine angle tumor. ( 11889382 )
2002
33
Renal carcinoma metastasis: an unusual cerebellopontine angle tumor. ( 12297820 )
2002
34
Endolymphatic sac tumor: a rare cerebellopontine angle tumor. ( 12577100 )
2002
35
Pain relief by stellate ganglion block in a case with trigeminal neuralgia caused by a cerebellopontine angle tumor. ( 15384297 )
2002
36
Pathologic quiz case: an unusual cerebellopontine angle tumor. ( 11473473 )
2001
37
Cerebellopontine angle tumor composed of Schwann and meningeal proliferations. ( 11701080 )
2001
38
Neurosarcoidosis: An unusual case presenting as a cerebellopontine angle tumor. ( 10471878 )
1999
39
Cerebellopontine angle tumor outcomes in patients with hazardous occupations. ( 9396673 )
1997
40
Evoked facial nerve EMG and brainstem auditory evoked potential monitoring in cerebellopontine angle tumor resection. ( 9407677 )
1997
41
Sudden contralateral deafness following cerebellopontine angle tumor surgery. ( 8172310 )
1994
42
Hearing preservation in cerebellopontine angle tumor surgery: the NYU experience 1974-1991. ( 8122702 )
1993
43
The simultaneous use of electrocochleogram, brainstem auditory evoked potential and facial muscle EMG in cerebellopontine angle tumor removal. ( 1358342 )
1992
44
Facial nerve repair techniques in cerebellopontine angle tumor surgery. ( 1415500 )
1992
45
Cerebellar metastasis from prostatic carcinoma simulating, on CT-scan, a cerebellopontine angle tumor. Case report. ( 2718811 )
1989
46
Effects of cerebellar retraction on brainstem auditory evoked potentials in an experimental animal model of cerebellopontine angle tumor. ( 2784229 )
1989
47
Effects of cerebellar retraction on brainstem auditory evoked potentials in an experimental animal model of cerebellopontine angle tumor. ( 3257305 )
1988
48
Cerebellopontine angle tumor causing contralateral trigeminal neuralgia: a case report. ( 3497359 )
1987
49
Facial nerve function in cerebellopontine angle tumor surgery. ( 3878090 )
1985
50
Chronic granulomatous abscess simulating cerebellopontine angle tumor. ( 6435434 )
1984

Variations for Cerebellopontine Angle Tumor

Expression for Cerebellopontine Angle Tumor

Search GEO for disease gene expression data for Cerebellopontine Angle Tumor.

Pathways for Cerebellopontine Angle Tumor

GO Terms for Cerebellopontine Angle Tumor

Biological processes related to Cerebellopontine Angle Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell-matrix adhesion GO:0001953 9.16 JAG1 NF2
2 negative regulation of cell-cell adhesion GO:0022408 8.96 JAG1 NF2
3 pulmonary valve morphogenesis GO:0003184 8.62 HEYL JAG1

Sources for Cerebellopontine Angle Tumor

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