MCID: CRB029
MIFTS: 39

Cerebellopontine Angle Tumor

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Cerebellopontine Angle Tumor

MalaCards integrated aliases for Cerebellopontine Angle Tumor:

Name: Cerebellopontine Angle Tumor 12 15 74
Neoplasm of the Cerebellopontine Angle 12

Classifications:



External Ids:

Disease Ontology 12 DOID:3200
NCIt 51 C5414
UMLS 74 C0474740

Summaries for Cerebellopontine Angle Tumor

Disease Ontology : 12 A brain stem cancer that is characterized by neoplasms in the fossa located in cerebellopotine angle.

MalaCards based summary : Cerebellopontine Angle Tumor, also known as neoplasm of the cerebellopontine angle, is related to neurilemmoma and acoustic neuroma. An important gene associated with Cerebellopontine Angle Tumor is SDHD (Succinate Dehydrogenase Complex Subunit D). The drugs Anti-Bacterial Agents and Gentamicins have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and prostate, and related phenotypes are Decreased viability and Decreased viability

Related Diseases for Cerebellopontine Angle Tumor

Diseases related to Cerebellopontine Angle Tumor via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 98)
# Related Disease Score Top Affiliating Genes
1 neurilemmoma 30.6 GFAP NF2 SMARCB1
2 acoustic neuroma 11.9
3 monosomy 22 10.4 NF2 SMARCB1
4 schwannomatosis 1 10.4 NF2 SMARCB1
5 melanotic medulloblastoma 10.4 GFAP SMARCB1
6 trigeminal neuralgia 10.4
7 cerebral convexity meningioma 10.4 GFAP NF2
8 intraventricular meningioma 10.4 GFAP NF2
9 cornea cancer 10.4 GFAP NF2
10 nodular medulloblastoma 10.4 GFAP SMARCB1
11 plexiform schwannoma 10.3 GFAP NF2
12 cerebellopontine angle meningioma 10.3 HEYL KANTR
13 desmoplastic infantile ganglioglioma 10.3 GFAP SYP
14 spinal cancer 10.3 GFAP NF2
15 lung combined type small cell carcinoma 10.3 GFAP SYP
16 pancreatic serous cystadenoma 10.3 PTCRA SYP
17 olfactory groove meningioma 10.3 NF2 SYP
18 mixed glioma 10.3 GFAP IDH1
19 cellular ependymoma 10.3 GFAP SYP
20 chordoid meningioma 10.3 GFAP SYP
21 central nervous system primitive neuroectodermal neoplasm 10.3 GFAP SYP
22 extraosseous chondrosarcoma 10.3 SMARCB1 SYP
23 chordoid glioma 10.3 GFAP NF2
24 clear cell ependymoma 10.3 GFAP SYP
25 chiari malformation 10.3 GFAP SYP
26 atypical neurofibroma 10.3 GFAP NF2
27 cerebral neuroblastoma 10.3 GFAP SYP
28 foramen magnum meningioma 10.3 KANTR NF2
29 subependymal glioma 10.3 GFAP SYP
30 astroblastoma 10.3 GFAP SYP
31 rhabdoid meningioma 10.3 GFAP NF2 SMARCB1
32 pineal gland cancer 10.3 GFAP SYP
33 melanotic neuroectodermal tumor 10.3 GFAP SYP
34 splenic artery aneurysm 10.2 PCSK1N SAA1
35 glioma susceptibility 1 10.2 GFAP IDH1
36 neuroma 10.2 GFAP NF2 SMARCB1
37 obstructive hydrocephalus 10.2 GFAP SYP
38 subclavian artery aneurysm 10.2 PCSK1N SAA1
39 rhabdoid cancer 10.2 SMARCB1 SYP
40 medulloepithelioma 10.2 GFAP SYP
41 malignant ependymoma 10.2 GFAP NF2
42 cerebral ventricle cancer 10.2 GFAP SMARCB1 SYP
43 pineocytoma 10.2 GFAP SYP
44 cerebellar liponeurocytoma 10.2 GFAP SMARCB1 SYP
45 ependymoma 10.2 GFAP NF2 SYP
46 medullomyoblastoma 10.2 GFAP SMARCB1 SYP
47 carcinoid tumors, intestinal 10.2 SDHD SYP
48 benign ependymoma 10.2 GFAP NF2 SYP
49 infratentorial cancer 10.2 GFAP SMARCB1 SYP
50 progesterone resistance 10.2 ESR2 FKBP4

Graphical network of the top 20 diseases related to Cerebellopontine Angle Tumor:



Diseases related to Cerebellopontine Angle Tumor

Symptoms & Phenotypes for Cerebellopontine Angle Tumor

GenomeRNAi Phenotypes related to Cerebellopontine Angle Tumor according to GeneCards Suite gene sharing:

27
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Decreased viability GR00221-A-1 10.02 SDHD SMARCB1
2 Decreased viability GR00221-A-2 10.02 SDHD SMARCB1
3 Decreased viability GR00221-A-3 10.02 SMARCB1
4 Decreased viability GR00221-A-4 10.02 SDHD
5 Decreased viability GR00381-A-1 10.02 EXOSC1 FKBP4 GFAP PTCRA SAA1 SDHD
6 Decreased viability GR00381-A-3 10.02 SAA1
7 Decreased viability GR00402-S-2 10.02 EXOSC1 FKBP4 GFAP PTCRA SAA1 SDHD
8 Increased proliferation GR00094-A 8.62 NF2 SMARCB1

MGI Mouse Phenotypes related to Cerebellopontine Angle Tumor:

47
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.2 CTSS CYP11B1 ESR2 GFAP HEYL JAG1
2 cellular MP:0005384 10.14 CTSS CYP11B1 ESR2 FKBP4 GFAP HEYL
3 growth/size/body region MP:0005378 10.1 CYP11B1 ESR2 FAM107B FKBP4 GFAP HEYL
4 cardiovascular system MP:0005385 10.09 CTSS CYP11B1 ESR2 GFAP HEYL JAG1
5 homeostasis/metabolism MP:0005376 9.93 CTSS CYP11B1 ESR2 FKBP4 GFAP IDH1
6 endocrine/exocrine gland MP:0005379 9.92 CTSS CYP11B1 ESR2 FKBP4 JAG1 NF2
7 digestive/alimentary MP:0005381 9.91 CTSS ESR2 FKBP4 GFAP JAG1 PCSK1N
8 mortality/aging MP:0010768 9.73 CYP11B1 ESR2 FKBP4 GFAP HEYL IDH1
9 muscle MP:0005369 9.23 CTSS CYP11B1 ESR2 GFAP HEYL JAG1

Drugs & Therapeutics for Cerebellopontine Angle Tumor

Drugs for Cerebellopontine Angle Tumor (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 59)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Anti-Bacterial Agents Phase 4,Phase 2,Not Applicable,Early Phase 1
2 Gentamicins Phase 4,Not Applicable
3 Anti-Infective Agents Phase 4,Phase 2,Not Applicable,Early Phase 1
4
Prednisolone phosphate Approved, Vet_approved Phase 3 302-25-0
5
Prednisolone Approved, Vet_approved Phase 3 50-24-8 5755
6
Methylprednisolone hemisuccinate Approved Phase 3 2921-57-5
7
Methylprednisolone Approved, Vet_approved Phase 3 83-43-2 6741
8
Prednisolone hemisuccinate Experimental Phase 3 2920-86-7
9 Anti-Inflammatory Agents Phase 3,Phase 2
10 Peripheral Nervous System Agents Phase 3,Phase 2
11 Prednisolone acetate Phase 3
12 Autonomic Agents Phase 3
13 Hormones Phase 3
14 Antineoplastic Agents, Hormonal Phase 3
15 Hormone Antagonists Phase 3
16 Antiemetics Phase 3
17 Methylprednisolone Acetate Phase 3
18 Neuroprotective Agents Phase 3
19 Gastrointestinal Agents Phase 3
20 glucocorticoids Phase 3
21 Hormones, Hormone Substitutes, and Hormone Antagonists Phase 3
22 Protective Agents Phase 3
23
Bevacizumab Approved, Investigational Phase 2,Phase 1 216974-75-3
24
Miconazole Approved, Investigational, Vet_approved Phase 2,Early Phase 1 22916-47-8 4189
25
Sirolimus Approved, Investigational Phase 2,Early Phase 1 53123-88-9 46835353 6436030 5284616
26
Everolimus Approved Phase 2,Early Phase 1 159351-69-6 6442177 70789204
27
Aspirin Approved, Vet_approved Phase 2 50-78-2 2244
28
Axitinib Approved, Investigational Phase 2 319460-85-0 6450551
29
Lapatinib Approved March 2007, Investigational Phase 2,Early Phase 1 388082-78-8, 231277-92-2 208908 9941095
30
Lactitol Investigational Phase 2 585-86-4, 585-88-6 493591
31 Immunologic Factors Phase 2,Early Phase 1
32 Antibodies Phase 2
33 Antibodies, Monoclonal Phase 2
34 Antineoplastic Agents, Immunological Phase 2,Phase 1
35 Immunoglobulins Phase 2
36 Angiogenesis Inhibitors Phase 2,Phase 1
37 Angiogenesis Modulating Agents Phase 2,Phase 1
38 Immunosuppressive Agents Phase 2,Early Phase 1
39 Antibiotics, Antitubercular Phase 2,Early Phase 1
40 Antifungal Agents Phase 2,Early Phase 1
41 Endostatins Phase 2 71581480
42 Protein Kinase Inhibitors Phase 2,Early Phase 1
43 Platelet Aggregation Inhibitors Phase 2
44 Analgesics, Non-Narcotic Phase 2
45 Antirheumatic Agents Phase 2
46 Analgesics Phase 2
47 Cyclooxygenase Inhibitors Phase 2
48 Anti-Inflammatory Agents, Non-Steroidal Phase 2
49 Antipyretics Phase 2
50 Fibrinolytic Agents Phase 2

Interventional clinical trials:

(show top 50) (show all 59)
# Name Status NCT ID Phase Drugs
1 Gentamicin Treatment Prior to Schwannoma Surgery - Residual Function Unknown status NCT02379754 Phase 4 Gentamicins
2 Gentamicin Treatment Prior to Schwannoma Surgery - No Residual Function Recruiting NCT02415257 Phase 4 Gentamicin
3 Stereotactic Radiation in Vestibular Schwannoma Unknown status NCT01449604 Phase 3
4 Corticosteroids in Prevention of Facial Palsy After Cranial Base Surgery Completed NCT00438087 Phase 3 methylprednisolone
5 Cyberknife Radiosurgery for Patients With Neurinomas Recruiting NCT02055859 Phase 3
6 Icotinib Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Unknown status NCT02934256 Phase 2 Icotinib
7 Bevacizumab for Symptomatic Vestibular Schwannoma in Neurofibromatosis Type 2 (NF2) Completed NCT01207687 Phase 2
8 Efficacy and Safety Study of RAD001 in the Growth of the Vestibular Schwannoma(s) in Neurofibromatosis 2 (NF2) Patients Completed NCT01490476 Phase 2 RAD001
9 Endostatin Study for Patients With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Completed NCT02104323 Phase 2 Endostatin
10 Lapatinib Study for Children and Adults With Neurofibromatosis Type 2 (NF2) and NF2-Related Tumors Completed NCT00973739 Phase 2 Lapatinib
11 Phase II Study of Everolimus (RAD001) in Children and Adults With Neurofibromatosis Type 2 Completed NCT01419639 Phase 2 Everolimus (RAD001) , Afinitor®
12 Phase II Study of the Multichannel Auditory Brain Stem Implant for Deafness Following Surgery for Neurofibromatosis 2 Completed NCT00004437 Phase 2
13 RGD PET/MRI in Sporadic Vestibular Schwannoma Recruiting NCT03393689 Phase 2 One injection of 68Ga-NODAGA-E[c(RGDyK)]2
14 Hearing Outcomes Using Fractionated Proton Radiation Therapy for Vestibular Schwannoma Recruiting NCT01199978 Phase 2
15 Study of Aspirin in Patients With Vestibular Schwannoma Recruiting NCT03079999 Phase 2 Aspirin;Placebo
16 Trial of Selumetinib in Patients With Neurofibromatosis Type II Related Tumors Recruiting NCT03095248 Phase 2 Selumetinib
17 Phase 2 Study of Bevacizumab in Children and Young Adults With NF 2 and Progressive Vestibular Schwannomas Active, not recruiting NCT01767792 Phase 2 Bevacizumab
18 Study of RAD001 for Treatment of NF2-related Vestibular Schwannoma Active, not recruiting NCT01345136 Phase 2 RAD001, everolimus
19 Study of Axitinib in Patients With Neurofibromatosis Type 2 and Progressive Vestibular Schwannomas Active, not recruiting NCT02129647 Phase 2 Axitinib
20 AZD2014 In NF2 Patients With Progressive or Symptomatic Meningiomas Active, not recruiting NCT02831257 Phase 2 AZD2014
21 A Study of Nilotinib in Growing Vestibular Schwannomas Terminated NCT01201538 Phase 2 Nilotinib
22 Super-Selective Intraarterial Cerebral Infusion of Bevacizumab (Avastin) for Treatment of Vestibular Schwannoma Suspended NCT01083966 Phase 1 Bevacizumab (Avastin)
23 Vestibular Schwannoma and Psychological Factors Unknown status NCT01743248
24 Preoperative Vestibular Rehabilitation Effectiveness After Vestibular Schwannoma Surgery Unknown status NCT02275325 Not Applicable
25 Response Prediction After GKS in Patients With Vestibular Schwannoma Using DCE MR Imaging Unknown status NCT03097822
26 Effect of Implant Position on Magnetic Resonance Image Distortion Unknown status NCT02246231 Not Applicable
27 Taste Disorders in Middle Ear Disease and After Middle Ear Surgery Unknown status NCT01584011
28 Role of Psychiatric Profile in Prehabituated Patients After Vestibular Schwannoma Surgery Completed NCT03638310 Not Applicable
29 Vestibular Evaluation After Vestibular Schwannoma Treatment Completed NCT03670589
30 Vertigo Perception and Quality of Life in Patients After Surgical Treatment of Vestibular Schwannoma Completed NCT02963896 Not Applicable gentamicin
31 Concentration and Activity of Lapatinib in Vestibular Schwannomas Completed NCT00863122 Early Phase 1 lapatinib
32 WES of NF2-associated in Comparison to Sporadic Vestibular Schwannomas - Correlation With Clinical Data Completed NCT03210285
33 Cochlear Implantation After Labyrinthectomy or a Translabyrinthine Surgical Approach Completed NCT02309099 Not Applicable
34 Using Positron Emission Tomography to Predict Intracranial Tumor Growth in Neurofibromatosis Type II Patients Completed NCT01222728
35 Recovery of Visual Acuity in People With Vestibular Deficits Completed NCT00411216 Not Applicable
36 Resiliency Training for Patients With NF2 Via Videoconferencing With Skype Completed NCT02811718 Not Applicable
37 A Case-Referent Study of Brain Tumors in Adults Completed NCT00339300
38 A Family Study of Adults With Glioma Completed NCT00339352
39 Vasopressin and V2 Receptor in Meniere's Disease Completed NCT00599560 Not Applicable
40 Vestibular Outcomes in Vestibular Schwannoma Recruiting NCT03346889
41 Secondary Endolymphatic Hydrops and Vestibular Schwannomas on 3 Tesla MRI Recruiting NCT03593577
42 Simultaneous Translabyrinthine Surgery of Vestibular Schwannoma and Cochlear Implantation With Intraoperative eBERA and Correlation to Hearing Results Recruiting NCT03745560
43 Auditory Nerve Monitoring Using Intra-cochlear Stimulation in Subjects With Acoustic Neuroma Recruiting NCT02948790 Not Applicable
44 CI Following VS Removal or Labyrinthectomy Recruiting NCT03795675 Not Applicable
45 Cochlear Implantation After Gamma Knife Radiosurgery With eABR and Correlation to Postoperative Hearing Results - a Pilot Study Recruiting NCT03745534
46 Consequence of Unilateral Vestibular Loss on Visual Abilities Recruiting NCT03581331 Not Applicable
47 Protocol for Evaluating a Planning Algorithm for Gamma Knife Radiosurgery Recruiting NCT03520829
48 Maintaining Cochlear Patency After VIIIth Nerve Surgery Recruiting NCT03261726 Not Applicable
49 Natural History Study of Patients With Neurofibromatosis Type 2 Recruiting NCT00598351
50 Vegetative Monitoring During Brainstem-associated Surgery Recruiting NCT03666507

Search NIH Clinical Center for Cerebellopontine Angle Tumor

Genetic Tests for Cerebellopontine Angle Tumor

Anatomical Context for Cerebellopontine Angle Tumor

MalaCards organs/tissues related to Cerebellopontine Angle Tumor:

42
Brain, Testes, Prostate, Salivary Gland

The Foundational Model of Anatomy Ontology organs/tissues related to Cerebellopontine Angle Tumor:

20
Cerebellopotine Angle

Publications for Cerebellopontine Angle Tumor

Articles related to Cerebellopontine Angle Tumor:

(show top 50) (show all 54)
# Title Authors Year
1
Spontaneously Resolving Symptomatic Subdural Hygromas After Cerebellopontine Angle Tumor Surgery. ( 29101072 )
2018
2
Petrous Apex Pneumatization: Influence on Postoperative Cerebellopontine Angle Tumor Cerebrospinal Fluid Fistula. ( 29925246 )
2018
3
Focal hyperintensity in the dorsal brain stem of patients with cerebellopontine angle tumor: A high-resolution 3a88T MRI study. ( 29343821 )
2018
4
Glioneuronal Heterotopia Presenting as Cerebellopontine Angle Tumor of Cranial NerveA VIII. ( 29625310 )
2018
5
The relation between flocculus volume and tinnitus after cerebellopontine angle tumor surgery. ( 29398141 )
2018
6
Evaluation of balance after surgery for cerebellopontine angle tumor. ( 30248037 )
2018
7
Bilaterally Abnormal Head Impulse Tests Indicate a Large Cerebellopontine Angle Tumor. ( 26754780 )
2016
8
Early Nerve Grafting for Facial Paralysis After Cerebellopontine Angle Tumor Resection With Preserved Facial Nerve Continuity. ( 26584060 )
2016
9
Effect of corticosteroids on facial function after cerebellopontine angle tumor removal: a double-blind study versus placebo. ( 25924803 )
2015
10
Clinical use of skull tap vestibular evoked myogenic potentials for the diagnoses of the cerebellopontine angle tumor patients. ( 24804198 )
2014
11
Bruns nystagmus in cerebellopontine angle tumor. ( 23552728 )
2013
12
A 68-year old man with a cerebellopontine angle tumor. ( 23936919 )
2013
13
Transient cardiac asystole induced by electrocautery during excision of a cerebellopontine angle tumor. ( 24262476 )
2013
14
Retrosigmoid approach to cerebellopontine angle tumor resection: surgical modifications. ( 22815095 )
2012
15
Necrotizing meningoencephalitis mimicking cerebellopontine angle tumor as late complication following cochlear implantation. ( 22340754 )
2012
16
Intraoperative Transcranial Motor-Evoked Potential Monitoring of the Facial Nerve during Cerebellopontine Angle Tumor Resection. ( 24083121 )
2012
17
Early complications and symptoms of cerebellopontine angle tumor surgery: a prospective analysis. ( 21373897 )
2011
18
Concurrent vestibular schwannoma and meningioma mimicking a single cerebellopontine angle tumor. ( 20436847 )
2009
19
A 47-year old male with a cerebellopontine angle tumor. ( 19744047 )
2009
20
Chemical meningitis following cerebellopontine angle tumor surgery. ( 18312887 )
2008
21
Brain stem candidiasis mimicking cerebellopontine angle tumor. ( 18313733 )
2008
22
Cerebellopontine angle tumor in a patient with a maternally inherited SDHD gene mutation. ( 19205158 )
2008
23
Hyperventilation-induced nystagmus in peripheral vestibulopathy and cerebellopontine angle tumor. ( 17785675 )
2007
24
Intraoperative monitoring of hearing during cerebellopontine angle tumor surgery using transtympanic electrocochleography. ( 17529854 )
2007
25
Bilateral sudden sensorineural hearing loss as a presentation of metastatic adenocarcinoma of unknown primary mimicking cerebellopontine angle tumor on the magnetic resonance image. ( 16500481 )
2006
26
Unresponsiveness and pinpoint pupils after cerebellopontine angle tumor resection: opioid overdose versus postoperative hemorrhage. ( 16861457 )
2006
27
Approach design and closure techniques to minimize cerebrospinal fluid leak after cerebellopontine angle tumor surgery. ( 16272937 )
2005
28
Clinicoradiological review: symptomatic superior cerebellar artery aneurysm imitating cerebellopontine angle tumor. ( 15792523 )
2005
29
Distal anterior inferior cerebellar artery aneurysm masquerading as a cerebellopontine angle tumor: case report and review of literature. ( 16145591 )
2004
30
Endolymphatic sac tumor: a rare cerebellopontine angle tumor. ( 12577100 )
2002
31
Renal carcinoma metastasis: an unusual cerebellopontine angle tumor. ( 12297820 )
2002
32
Pain relief by stellate ganglion block in a case with trigeminal neuralgia caused by a cerebellopontine angle tumor. ( 15384297 )
2002
33
Preoperative versus postoperative role of vestibular-evoked myogenic potentials in cerebellopontine angle tumor. ( 11889382 )
2002
34
Cerebellopontine angle tumor composed of Schwann and meningeal proliferations. ( 11701080 )
2001
35
Pathologic quiz case: an unusual cerebellopontine angle tumor. ( 11473473 )
2001
36
Neurosarcoidosis: An unusual case presenting as a cerebellopontine angle tumor. ( 10471878 )
1999
37
Evoked facial nerve EMG and brainstem auditory evoked potential monitoring in cerebellopontine angle tumor resection. ( 9407677 )
1997
38
Cerebellopontine angle tumor outcomes in patients with hazardous occupations. ( 9396673 )
1997
39
Sudden contralateral deafness following cerebellopontine angle tumor surgery. ( 8172310 )
1994
40
Hearing preservation in cerebellopontine angle tumor surgery: the NYU experience 1974-1991. ( 8122702 )
1993
41
The simultaneous use of electrocochleogram, brainstem auditory evoked potential and facial muscle EMG in cerebellopontine angle tumor removal. ( 1358342 )
1992
42
Facial nerve repair techniques in cerebellopontine angle tumor surgery. ( 1415500 )
1992
43
Cerebellar metastasis from prostatic carcinoma simulating, on CT-scan, a cerebellopontine angle tumor. Case report. ( 2718811 )
1989
44
Effects of cerebellar retraction on brainstem auditory evoked potentials in an experimental animal model of cerebellopontine angle tumor. ( 2784229 )
1989
45
Effects of cerebellar retraction on brainstem auditory evoked potentials in an experimental animal model of cerebellopontine angle tumor. ( 3257305 )
1988
46
Cerebellopontine angle tumor causing contralateral trigeminal neuralgia: a case report. ( 3497359 )
1987
47
Facial nerve function in cerebellopontine angle tumor surgery. ( 3878090 )
1985
48
Chronic granulomatous abscess simulating cerebellopontine angle tumor. ( 6435434 )
1984
49
Salivary gland heterotopia: a unique cerebellopontine angle tumor. ( 6274273 )
1982
50
Giant aneurysm of the anterior inferior cerebellar artery simulating a cerebellopontine angle tumor. ( 6981217 )
1982

Variations for Cerebellopontine Angle Tumor

Expression for Cerebellopontine Angle Tumor

Search GEO for disease gene expression data for Cerebellopontine Angle Tumor.

Pathways for Cerebellopontine Angle Tumor

GO Terms for Cerebellopontine Angle Tumor

Biological processes related to Cerebellopontine Angle Tumor according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of cell-matrix adhesion GO:0001953 9.16 JAG1 NF2
2 negative regulation of cell-cell adhesion GO:0022408 8.96 JAG1 NF2
3 pulmonary valve morphogenesis GO:0003184 8.62 HEYL JAG1

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