MCID: CRB030
MIFTS: 36

Cerebellum Cancer

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Cerebellum Cancer

MalaCards integrated aliases for Cerebellum Cancer:

Name: Cerebellum Cancer 12 15 17
Cerebellar Neoplasms 44 72
Malignant Neoplasm of Cerebellum 72
Malignant Tumor of Cerebellum 12
Cerebellar Cancer 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4205
ICD9CM 35 191.6
MeSH 44 D002528
NCIt 50 C2935 C3569
ICD10 33 C71.6
UMLS 72 C0007762 C0153640

Summaries for Cerebellum Cancer

MalaCards based summary : Cerebellum Cancer, also known as cerebellar neoplasms, is related to cerebellar medulloblastoma and hemangioblastoma, and has symptoms including cerebellar ataxia An important gene associated with Cerebellum Cancer is SAG (S-Antigen Visual Arrestin), and among its related pathways/superpathways are Neuroscience and Development_Hedgehog and PTH signaling pathways in bone and cartilage development. The drug Vaccines has been mentioned in the context of this disorder. Affiliated tissues include cerebellum, brain and eye, and related phenotypes are behavior/neurological and nervous system

Related Diseases for Cerebellum Cancer

Diseases related to Cerebellum Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 138)
# Related Disease Score Top Affiliating Genes
1 cerebellar medulloblastoma 32.0 MBNL3 ENO2
2 hemangioblastoma 29.6 SYP ENO2
3 medulloblastoma 26.7 SYP SHH PTCH1 MAP2 IDH1 ENO2
4 adult cerebellar neoplasm 12.2
5 childhood cerebellar neoplasm 12.2
6 panophthalmitis 10.5 SYP SAG
7 pineoblastoma 10.5 SYP SAG
8 gastric tubular adenocarcinoma 10.4 SYP SHH
9 ependymoma 10.4 SYP ENO2
10 purulent endophthalmitis 10.4 SYP SAG
11 carotid body cancer 10.4 SYP ENO2
12 urinary bladder small cell neuroendocrine carcinoma 10.4 SYP ENO2
13 extraventricular neurocytoma 10.4 SYP IDH1
14 malignant sertoli cell tumor 10.4 SYP ENO2
15 auditory system cancer 10.4 SYP ENO2
16 sinonasal undifferentiated carcinoma 10.4 SYP ENO2
17 small cell carcinoma 10.4 SYP ENO2
18 small cell carcinoma of the bladder 10.4 SYP ENO2
19 extrahepatic bile duct adenocarcinoma 10.4 SYP ENO2
20 cutaneous ganglioneuroma 10.4 SYP ENO2
21 ganglioneuroma 10.4 SYP ENO2
22 pancreatic somatostatinoma 10.4 SYP ENO2
23 middle ear adenoma 10.4 SYP ENO2
24 orbital cancer 10.4 SYP ENO2
25 sensory organ benign neoplasm 10.4 SYP ENO2
26 atypical follicular adenoma 10.4 SYP ENO2
27 gallbladder small cell carcinoma 10.4 SYP ENO2
28 pulmonary large cell neuroendocrine carcinoma 10.4 SYP ENO2
29 cancer-associated retinopathy 10.4 SAG ENO2
30 large cell neuroendocrine carcinoma 10.4 SYP ENO2
31 clear cell ependymoma 10.4 SYP ENO2
32 central nervous system primitive neuroectodermal neoplasm 10.4 SYP ENO2
33 endometrial small cell carcinoma 10.4 SYP ENO2
34 cauda equina neoplasm 10.4 SYP ENO2
35 cerebral neuroblastoma 10.4 SYP ENO2
36 astroblastoma 10.4 SYP ENO2
37 malignant teratoma 10.4 SYP ENO2
38 subependymal glioma 10.4 SYP ENO2
39 extraosseous chondrosarcoma 10.4 SYP ENO2
40 olfactory nerve neoplasm 10.3 SYP ENO2
41 cerebral ventricle cancer 10.3 SYP ENO2
42 angiocentric glioma 10.3 SYP IDH1
43 nodular ganglioneuroblastoma 10.3 SYP ENO2
44 ganglioneuroblastoma 10.3 SYP ENO2
45 benign ependymoma 10.3 SYP ENO2
46 melanotic neuroectodermal tumor 10.3 SYP ENO2
47 goblet cell carcinoid 10.3 ENO2 ATOH1
48 autonomic nervous system benign neoplasm 10.3 SYP ENO2
49 subependymoma 10.3 SYP ENO2
50 desmoplastic small round cell tumor 10.3 SYP ENO2

Comorbidity relations with Cerebellum Cancer via Phenotypic Disease Network (PDN):


Obstructive Hydrocephalus

Graphical network of the top 20 diseases related to Cerebellum Cancer:



Diseases related to Cerebellum Cancer

Symptoms & Phenotypes for Cerebellum Cancer

UMLS symptoms related to Cerebellum Cancer:


cerebellar ataxia

MGI Mouse Phenotypes related to Cerebellum Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.8 ATOH1 ENO2 MAP2 MBNL3 PTCH1 SHH
2 nervous system MP:0003631 9.7 ATOH1 ENO2 MAP2 PTCH1 SAG SHH
3 respiratory system MP:0005388 9.35 ATOH1 ENO2 IDH1 PTCH1 SHH
4 taste/olfaction MP:0005394 8.8 ENO2 PTCH1 SHH

Drugs & Therapeutics for Cerebellum Cancer

Drugs for Cerebellum Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 1 Trial of Engineered HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors Not yet recruiting NCT03911388 Phase 1
2 Cerebellar Tumors of Childhood - Impact on Cognition and Functional Connectivity Unknown status NCT01730274
3 The Impact of Cerebellar Mass Resection on Pain Processing Completed NCT02261649

Search NIH Clinical Center for Cerebellum Cancer

Cochrane evidence based reviews: cerebellar neoplasms

Genetic Tests for Cerebellum Cancer

Anatomical Context for Cerebellum Cancer

MalaCards organs/tissues related to Cerebellum Cancer:

41
Cerebellum, Brain, Eye, Endothelial, Cortex

Publications for Cerebellum Cancer

Articles related to Cerebellum Cancer:

(show all 30)
# Title Authors PMID Year
1
Acute post-infectious cerebellar ataxia due to co-infection of human herpesvirus-6 and adenovirus mimicking myositis. 38
25425177 2014
2
Diffusion-weighted imaging and pathological correlation in pediatric medulloblastomas-"They are not always restricted!". 38
21732119 2011
3
Pediatric cerebellar pilomyxoid-spectrum astrocytomas. 38
21721894 2011
4
Use of T2 signal intensity of cerebellar neoplasms in pediatric patients to guide preoperative staging of the neuraxis. 38
21284463 2011
5
Findings on preoperative brain MRI predict histopathology in children with cerebellar neoplasms. 38
21921669 2011
6
Hedgehog signaling promotes the degradation of tumor suppressor Sufu through the ubiquitin-proteasome pathway. 38
18997815 2009
7
Cerebellar liponeurocytoma with an unusually aggressive clinical course: case report. 38
14633310 2003
8
Trilateral retinoblastoma variant indicative of the relevance of the retinoblastoma tumor-suppressor pathway to medulloblastomas in humans. 38
11702879 2001
9
Pleomorphic xanthoastrocytoma of the cerebellum. 38
11048750 2000
10
Detection of human neurotropic JC virus DNA sequence and expression of the viral oncogenic protein in pediatric medulloblastomas. 38
10500209 1999
11
HPV in situ hybridization with catalyzed signal amplification and polymerase chain reaction in establishing cerebellar metastasis of a cervical carcinoma. 38
10333232 1999
12
Unusual cerebellar ganglioglioma with marked cytologic atypia. 38
9050064 1997
13
Medullocytoma (lipidized medulloblastoma). A cerebellar neoplasm of adults with favorable prognosis. 38
8651344 1996
14
Large-cell medulloblastomas. A distinct variant with highly aggressive behavior. 38
1530108 1992
15
Cerebellorubral degeneration after resection of cerebellar dentate nucleus neoplasms: evaluation with MR imaging. 38
2052699 1991
16
Cerebellar neoplasms in children. 38
2385809 1990
17
Cerebellar hemangioblastoma: computed tomographic, angiographic and clinical correlation in seven cases. 38
570102 1978
18
Melanotic medulloblastoma. Report of a case with ultrastructural findings. 38
690672 1978
19
Disorders in cerebellar ocular motor control. I. Saccadic overshoot dysmetria. An oculographic, control system and clinico-anatomical analysis. 38
1000283 1976
20
[A specific organelle in the vascular endothelial cells of cerebellar neoplasms (author's transl)]. 38
1237807 1975
21
[Differential diagnosis of metastatic and primary cerebellar neoplasms]. 38
1210234 1975
22
[Echoencephalography in the diagnosis of cerebellar neoplasms]. 38
4409313 1974
23
[Cerebellar neoplasms in children]. 38
4516047 1973
24
[Tremorography in the diagnosis of cerebellar neoplasms]. 38
5138536 1971
25
[Methods of in vitro culture of anaplastic cerebellar neoplasms]. 38
5420342 1970
26
[Cerebellar neoplasms in childhood]. 38
5778923 1969
27
[Value and significance of the otoneurologic examination in expansive lesions of the cerebellum. Considerations on cerebello-vestibular interdependence as observed from the clinical and physiopathologic study of 42 cases of cerebellar neoplasms]. 38
5306021 1967
28
[Eye motility in cerebellar neoplasms]. 38
5830293 1964
29
[Problems with open surgery for cerebellar neoplasms]. 38
14020067 1963
30
The transitory superficial granular layer of the cerebellar cortex; its relationship to certain cerebellar neoplasms. 38
15436307 1950

Variations for Cerebellum Cancer

Expression for Cerebellum Cancer

Search GEO for disease gene expression data for Cerebellum Cancer.

Pathways for Cerebellum Cancer

Pathways related to Cerebellum Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.99 SYP SAG MAP2 ENO2
2 10.91 SHH PTCH1
3
Show member pathways
10.73 SHH PTCH1
4 10.7 SYP SHH MAP2
5 9.86 SHH PTCH1

GO Terms for Cerebellum Cancer

Cellular components related to Cerebellum Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 photoreceptor inner segment GO:0001917 8.96 SAG ENO2
2 dendritic growth cone GO:0044294 8.62 PTCH1 MAP2

Biological processes related to Cerebellum Cancer according to GeneCards Suite gene sharing:

(show all 12)
# Name GO ID Score Top Affiliating Genes
1 embryonic limb morphogenesis GO:0030326 9.51 SHH PTCH1
2 inner ear development GO:0048839 9.49 SHH ATOH1
3 branching involved in ureteric bud morphogenesis GO:0001658 9.48 SHH PTCH1
4 cellular response to organic substance GO:0071310 9.46 SYP MAP2
5 dorsal/ventral pattern formation GO:0009953 9.43 SHH PTCH1
6 establishment of cell polarity GO:0030010 9.4 SHH MAP2
7 embryonic organ development GO:0048568 9.37 SHH PTCH1
8 renal system development GO:0072001 9.32 SHH PTCH1
9 spinal cord motor neuron differentiation GO:0021522 9.26 SHH PTCH1
10 somite development GO:0061053 9.16 SHH PTCH1
11 prostate gland development GO:0030850 8.96 SHH PTCH1
12 dorsal/ventral neural tube patterning GO:0021904 8.62 SHH PTCH1

Molecular functions related to Cerebellum Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cholesterol binding GO:0015485 8.96 SYP PTCH1
2 patched binding GO:0005113 8.62 SHH PTCH1

Sources for Cerebellum Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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