MCID: CRB030
MIFTS: 32

Cerebellum Cancer

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Cerebellum Cancer

MalaCards integrated aliases for Cerebellum Cancer:

Name: Cerebellum Cancer 12 15
Cerebellar Neoplasms 44 73
Malignant Neoplasm of Cerebellum 73
Malignant Tumor of Cerebellum 12
Cerebellar Cancer 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4205
ICD10 33 C71.6
ICD9CM 35 191.6
MeSH 44 D002528
NCIt 50 C2935 C3569

Summaries for Cerebellum Cancer

MalaCards based summary : Cerebellum Cancer, also known as cerebellar neoplasms, is related to cerebellar medulloblastoma and adult cerebellar neoplasm, and has symptoms including cerebellar ataxia An important gene associated with Cerebellum Cancer is SYP (Synaptophysin), and among its related pathways/superpathways are Neuroscience and Wnt Signaling Pathways: beta-Catenin-dependent Wnt Signaling. Affiliated tissues include cerebellum, and related phenotypes are behavior/neurological and nervous system

Related Diseases for Cerebellum Cancer

Diseases related to Cerebellum Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 144)
# Related Disease Score Top Affiliating Genes
1 cerebellar medulloblastoma 31.6 ENO2 MBNL3
2 adult cerebellar neoplasm 11.9
3 childhood cerebellar neoplasm 11.9
4 cellular ependymoma 10.7 SYP TP53
5 glycogen-rich clear cell breast carcinoma 10.7 SYP TP53
6 pulmonary blastoma 10.6 SYP TP53
7 central nervous system organ benign neoplasm 10.6 SYP TP53
8 papilloma of choroid plexus 10.6 SYP TP53
9 myxosarcoma 10.6 SYP TP53
10 chiari malformation 10.5 MAP2 SYP
11 dysembryoplastic neuroepithelial tumor 10.5 MAP2 SYP
12 sweat gland cancer 10.5 SYP TP53
13 rosette-forming glioneuronal tumor 10.5 MAP2 SYP
14 giant cell glioblastoma 10.5 SYP TP53
15 ureter small cell carcinoma 10.4 ENO2 SYP
16 malignant sertoli cell tumor 10.4 ENO2 SYP
17 pleuropulmonary blastoma 10.4 SHH TP53
18 urinary bladder small cell neuroendocrine carcinoma 10.4 ENO2 SYP
19 auditory system cancer 10.4 ENO2 SYP
20 sinonasal undifferentiated carcinoma 10.4 ENO2 SYP
21 sensory organ benign neoplasm 10.4 ENO2 SYP
22 gallbladder small cell carcinoma 10.4 ENO2 SYP
23 pancreatic somatostatinoma 10.4 ENO2 SYP
24 atypical teratoid rhabdoid tumor 10.4 SYP TP53
25 cutaneous ganglioneuroma 10.4 ENO2 SYP
26 extrahepatic bile duct adenocarcinoma 10.4 ENO2 SYP
27 small cell carcinoma of the bladder 10.4 ENO2 SYP
28 orbital cancer 10.4 ENO2 SYP
29 middle ear adenoma 10.4 ENO2 SYP
30 ovarian carcinosarcoma 10.4 ENO2 SYP
31 pulmonary large cell neuroendocrine carcinoma 10.4 ENO2 SYP
32 subependymal glioma 10.4 ENO2 SYP
33 olfactory nerve neoplasm 10.4 ENO2 SYP
34 cauda equina neoplasm 10.4 ENO2 SYP
35 extraosseous chondrosarcoma 10.4 ENO2 SYP
36 benign ependymoma 10.4 ENO2 SYP
37 malignant teratoma 10.4 ENO2 SYP
38 astroblastoma 10.4 ENO2 SYP
39 pineal gland cancer 10.4 ENO2 SYP
40 gastric tubular adenocarcinoma 10.4 SHH SYP
41 endometrial small cell carcinoma 10.4 ENO2 SYP
42 melanotic neuroectodermal tumor 10.4 ENO2 SYP
43 nodular ganglioneuroblastoma 10.4 ENO2 SYP
44 mucinous ovarian cystadenoma 10.4 ENO2 SYP
45 pineocytoma 10.4 ENO2 SYP
46 respiratory system benign neoplasm 10.4 ENO2 SYP
47 angiomyoma 10.4 ENO2 SYP
48 gastric small cell carcinoma 10.3 ENO2 SYP
49 desmoplastic small round cell tumor 10.3 ENO2 SYP
50 subependymoma 10.3 ENO2 SYP

Comorbidity relations with Cerebellum Cancer via Phenotypic Disease Network (PDN):


Obstructive Hydrocephalus

Graphical network of the top 20 diseases related to Cerebellum Cancer:



Diseases related to Cerebellum Cancer

Symptoms & Phenotypes for Cerebellum Cancer

UMLS symptoms related to Cerebellum Cancer:


cerebellar ataxia

MGI Mouse Phenotypes related to Cerebellum Cancer:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 9.87 TP53 ATOH1 ENO2 MAP2 MBNL3 SHH
2 nervous system MP:0003631 9.8 TP53 ATOH1 ENO2 MAP2 SHH SUFU
3 no phenotypic analysis MP:0003012 9.55 TP53 ATOH1 MBNL3 SHH SUFU
4 normal MP:0002873 9.35 SYP TP53 ATOH1 SHH SUFU
5 respiratory system MP:0005388 9.02 TP53 ATOH1 ENO2 SHH SUFU

Drugs & Therapeutics for Cerebellum Cancer

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Cerebellum - Cognitive Outcome and Functional Connectivity Unknown status NCT01730274
2 Impact of Cerebellar Mass Resection on Pain Processing Completed NCT02261649
3 Advanced MRI for Posterior Fossa Tumours Not yet recruiting NCT03471026

Search NIH Clinical Center for Cerebellum Cancer

Cochrane evidence based reviews: cerebellar neoplasms

Genetic Tests for Cerebellum Cancer

Anatomical Context for Cerebellum Cancer

MalaCards organs/tissues related to Cerebellum Cancer:

41
Cerebellum

Publications for Cerebellum Cancer

Variations for Cerebellum Cancer

Expression for Cerebellum Cancer

Search GEO for disease gene expression data for Cerebellum Cancer.

Pathways for Cerebellum Cancer

Pathways related to Cerebellum Cancer according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.97 ENO2 MAP2 SYP
2
Show member pathways
11.31 SHH SUFU TP53
3 10.78 MAP2 TP53
4 10.7 MAP2 SHH SYP

GO Terms for Cerebellum Cancer

Biological processes related to Cerebellum Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 heart looping GO:0001947 9.4 SHH SUFU
2 inner ear development GO:0048839 9.37 ATOH1 SHH
3 multicellular organism development GO:0007275 9.35 ATOH1 MBNL3 SHH SUFU TP53
4 skin development GO:0043588 9.32 SHH SUFU
5 cellular response to organic substance GO:0071310 9.26 MAP2 SYP
6 establishment of cell polarity GO:0030010 9.16 MAP2 SHH
7 spinal cord dorsal/ventral patterning GO:0021513 8.62 SHH SUFU

Molecular functions related to Cerebellum Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 protein self-association GO:0043621 8.62 SYP TP53

Sources for Cerebellum Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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