MCID: CRB030
MIFTS: 38

Cerebellum Cancer

Categories: Cancer diseases, Neuronal diseases

Aliases & Classifications for Cerebellum Cancer

MalaCards integrated aliases for Cerebellum Cancer:

Name: Cerebellum Cancer 12 15 17
Cerebellar Neoplasms 43 71
Malignant Neoplasm of Cerebellum 71
Malignant Tumor of Cerebellum 12
Cerebellar Cancer 12

Classifications:



External Ids:

Disease Ontology 12 DOID:4205
ICD9CM 34 191.6
MeSH 43 D002528
NCIt 49 C2935 C3569
SNOMED-CT 67 126960003 449420002
ICD10 32 C71.6
UMLS 71 C0007762 C0153640

Summaries for Cerebellum Cancer

MalaCards based summary : Cerebellum Cancer, also known as cerebellar neoplasms, is related to hemangioblastoma and cerebellar medulloblastoma, and has symptoms including cerebellar ataxia An important gene associated with Cerebellum Cancer is KIAA1549 (KIAA1549), and among its related pathways/superpathways are Translation Non-genomic (rapid) action of Androgen Receptor and Neuroscience. The drug Vaccines has been mentioned in the context of this disorder. Affiliated tissues include cerebellum, brain and eye, and related phenotypes are behavior/neurological and cellular

Related Diseases for Cerebellum Cancer

Diseases related to Cerebellum Cancer via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 275)
# Related Disease Score Top Affiliating Genes
1 hemangioblastoma 29.8 SYP GFAP ENO2
2 cerebellar medulloblastoma 29.5 TP53 SYP SHH SAG PTCH1 GLI1
3 li-fraumeni syndrome 28.8 TP53 SHH PTCH1 NF1 MYCN IDH1
4 rhabdomyosarcoma 28.4 TP53 SYP SHH PTCH1 MYCN GLI1
5 medulloblastoma 26.7 TP53 SYP SHH SAG PTCH1 NF1
6 adult cerebellar neoplasm 12.2
7 childhood cerebellar neoplasm 12.2
8 pediatric meningioma 10.5 KIAA1549 FAM131B
9 melanotic medulloblastoma 10.5 SHH PTCH1
10 myoblastoma 10.5 SYP ENO2
11 malignant melanocytic neoplasm of the peripheral nerve sheath 10.5 SYP ENO2
12 polydactyly, preaxial ii 10.5 SHH PTCH1
13 anal neuroendocrine tumor 10.5 SYP ENO2
14 breast neuroendocrine neoplasm 10.5 SYP ENO2
15 sinonasal undifferentiated carcinoma 10.5 SYP ENO2
16 papillary tumor of the pineal region 10.5 SYP ENO2
17 small cell carcinoma of the bladder 10.5 SYP ENO2
18 pineal region teratoma 10.5 SYP ENO2
19 intracranial primitive neuroectodermal tumor 10.5 SYP ENO2
20 auditory system benign neoplasm 10.5 SYP ENO2
21 appendix carcinoid tumor 10.5 SYP ENO2
22 auditory system cancer 10.5 SYP ENO2
23 extraosseous ewings sarcoma-primitive neuroepithelial tumor 10.5 SYP ENO2
24 cauda equina neoplasm 10.5 SYP ENO2
25 duodenal benign neoplasm 10.5 SYP ENO2
26 nodular prostate 10.5 SYP ENO2
27 ampulla of vater neoplasm 10.5 SYP ENO2
28 urinary bladder small cell neuroendocrine carcinoma 10.5 SYP ENO2
29 ureter small cell carcinoma 10.5 SYP ENO2
30 middle ear adenoma 10.5 SYP ENO2
31 holoprosencephaly 9 10.4 SHH PTCH1
32 jejunal neoplasm 10.4 SYP ENO2
33 carotid body cancer 10.4 SYP ENO2
34 gallbladder small cell carcinoma 10.4 SYP ENO2
35 pacinian tumor 10.4 NF1 ENO2
36 gastric small cell carcinoma 10.4 SYP ENO2
37 sensory organ benign neoplasm 10.4 SYP ENO2
38 internal auditory canal lipoma 10.4 PTCH1 IDH1
39 midline interhemispheric variant of holoprosencephaly 10.4 SHH PTCH1
40 pineal parenchymal tumor of intermediate differentiation 10.4 SYP ENO2
41 ovarian large-cell neuroendocrine carcinoma 10.4 SYP ENO2
42 septopreoptic holoprosencephaly 10.4 SHH PTCH1
43 small intestine leiomyoma 10.4 PTCH1 NF1
44 spinal cord astrocytoma 10.4 KIAA1549 IDH1
45 gastric hemangioma 10.4 SYP ENO2
46 plexiform schwannoma 10.4 NF1 ENO2
47 adult oligodendroglioma 10.4 KIAA1549 IDH1
48 lung oat cell carcinoma 10.4 SYP ENO2
49 cutaneous ganglioneuroma 10.4 SYP ENO2
50 cervix small cell carcinoma 10.4 SYP ENO2

Comorbidity relations with Cerebellum Cancer via Phenotypic Disease Network (PDN):


Obstructive Hydrocephalus

Graphical network of the top 20 diseases related to Cerebellum Cancer:



Diseases related to Cerebellum Cancer

Symptoms & Phenotypes for Cerebellum Cancer

UMLS symptoms related to Cerebellum Cancer:


cerebellar ataxia

MGI Mouse Phenotypes related to Cerebellum Cancer:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 behavior/neurological MP:0005386 10.21 ATOH1 CLCN6 ENO2 GFAP GLI1 KIAA1549
2 cellular MP:0005384 10.1 ATOH1 CLCN6 ENO2 GFAP GLI1 MYCN
3 nervous system MP:0003631 9.97 ATOH1 CLCN6 ENO2 GFAP GLI1 MYCN
4 digestive/alimentary MP:0005381 9.92 ATOH1 GFAP GLI1 MYCN NF1 PTCH1
5 craniofacial MP:0005382 9.91 ENO2 GLI1 MYCN NF1 PTCH1 SHH
6 limbs/digits/tail MP:0005371 9.73 GLI1 MYCN NF1 PTCH1 SHH TP53
7 normal MP:0002873 9.61 ATOH1 GFAP GLI1 MYCN NF1 PTCH1
8 respiratory system MP:0005388 9.28 ATOH1 ENO2 GLI1 IDH1 MYCN NF1

Drugs & Therapeutics for Cerebellum Cancer

Drugs for Cerebellum Cancer (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):


# Name Status Phase Clinical Trials Cas Number PubChem Id
1 Vaccines Phase 1

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Phase 1 Trial of Engineered HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors Recruiting NCT03911388 Phase 1
2 Cerebellar Tumors of Childhood - Impact on Cognition and Functional Connectivity Unknown status NCT01730274
3 The Impact of Cerebellar Mass Resection on Pain Processing Completed NCT02261649

Search NIH Clinical Center for Cerebellum Cancer

Cochrane evidence based reviews: cerebellar neoplasms

Genetic Tests for Cerebellum Cancer

Anatomical Context for Cerebellum Cancer

MalaCards organs/tissues related to Cerebellum Cancer:

40
Cerebellum, Brain, Eye, Cortex, Endothelial

Publications for Cerebellum Cancer

Articles related to Cerebellum Cancer:

(show all 30)
# Title Authors PMID Year
1
Acute post-infectious cerebellar ataxia due to co-infection of human herpesvirus-6 and adenovirus mimicking myositis. 61
25425177 2014
2
Diffusion-weighted imaging and pathological correlation in pediatric medulloblastomas-"They are not always restricted!". 61
21732119 2011
3
Pediatric cerebellar pilomyxoid-spectrum astrocytomas. 61
21721894 2011
4
Use of T2 signal intensity of cerebellar neoplasms in pediatric patients to guide preoperative staging of the neuraxis. 61
21284463 2011
5
Findings on preoperative brain MRI predict histopathology in children with cerebellar neoplasms. 61
21921669 2011
6
Hedgehog signaling promotes the degradation of tumor suppressor Sufu through the ubiquitin-proteasome pathway. 61
18997815 2009
7
Cerebellar liponeurocytoma with an unusually aggressive clinical course: case report. 61
14633310 2003
8
Trilateral retinoblastoma variant indicative of the relevance of the retinoblastoma tumor-suppressor pathway to medulloblastomas in humans. 61
11702879 2001
9
Pleomorphic xanthoastrocytoma of the cerebellum. 61
11048750 2000
10
Detection of human neurotropic JC virus DNA sequence and expression of the viral oncogenic protein in pediatric medulloblastomas. 61
10500209 1999
11
HPV in situ hybridization with catalyzed signal amplification and polymerase chain reaction in establishing cerebellar metastasis of a cervical carcinoma. 61
10333232 1999
12
Unusual cerebellar ganglioglioma with marked cytologic atypia. 61
9050064 1997
13
Medullocytoma (lipidized medulloblastoma). A cerebellar neoplasm of adults with favorable prognosis. 61
8651344 1996
14
Large-cell medulloblastomas. A distinct variant with highly aggressive behavior. 61
1530108 1992
15
Cerebellorubral degeneration after resection of cerebellar dentate nucleus neoplasms: evaluation with MR imaging. 61
2052699 1991
16
Cerebellar neoplasms in children. 61
2385809 1990
17
Cerebellar hemangioblastoma: computed tomographic, angiographic and clinical correlation in seven cases. 61
570102 1978
18
Melanotic medulloblastoma. Report of a case with ultrastructural findings. 61
690672 1978
19
Disorders in cerebellar ocular motor control. I. Saccadic overshoot dysmetria. An oculographic, control system and clinico-anatomical analysis. 61
1000283 1976
20
[A specific organelle in the vascular endothelial cells of cerebellar neoplasms (author's transl)]. 61
1237807 1975
21
[Differential diagnosis of metastatic and primary cerebellar neoplasms]. 61
1210234 1975
22
[Echoencephalography in the diagnosis of cerebellar neoplasms]. 61
4409313 1974
23
[Cerebellar neoplasms in children]. 61
4516047 1973
24
[Tremorography in the diagnosis of cerebellar neoplasms]. 61
5138536 1971
25
[Methods of in vitro culture of anaplastic cerebellar neoplasms]. 61
5420342 1970
26
[Cerebellar neoplasms in childhood]. 61
5778923 1969
27
[Value and significance of the otoneurologic examination in expansive lesions of the cerebellum. Considerations on cerebello-vestibular interdependence as observed from the clinical and physiopathologic study of 42 cases of cerebellar neoplasms]. 61
5306021 1967
28
[Eye motility in cerebellar neoplasms]. 61
5830293 1964
29
[Problems with open surgery for cerebellar neoplasms]. 61
14020067 1963
30
The transitory superficial granular layer of the cerebellar cortex; its relationship to certain cerebellar neoplasms. 61
15436307 1950

Variations for Cerebellum Cancer

Expression for Cerebellum Cancer

Search GEO for disease gene expression data for Cerebellum Cancer.

Pathways for Cerebellum Cancer

GO Terms for Cerebellum Cancer

Biological processes related to Cerebellum Cancer according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of transcription, DNA-templated GO:0045893 9.93 TP53 SHH PTCH1 MYCN GLI1
2 regulation of cell proliferation GO:0042127 9.71 TP53 SHH PTCH1 NF1
3 smoothened signaling pathway GO:0007224 9.61 SHH PTCH1 GLI1
4 somite development GO:0061053 9.56 SHH PTCH1
5 digestive tract morphogenesis GO:0048546 9.55 SHH GLI1
6 embryonic organ development GO:0048568 9.54 TP53 SHH PTCH1
7 dorsal/ventral neural tube patterning GO:0021904 9.52 SHH PTCH1
8 positive regulation of production of miRNAs involved in gene silencing by miRNA GO:1903800 9.51 TP53 MYCN
9 metanephric collecting duct development GO:0072205 9.49 SHH PTCH1
10 Bergmann glial cell differentiation GO:0060020 9.48 SHH GFAP
11 negative regulation of neuroblast proliferation GO:0007406 9.46 TP53 NF1
12 dorsal/ventral pattern formation GO:0009953 9.43 SHH PTCH1 GLI1
13 smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation GO:0021938 9.32 SHH GLI1
14 ventral midline development GO:0007418 9.16 SHH GLI1
15 smooth muscle tissue development GO:0048745 9.13 SHH PTCH1 NF1
16 prostate gland development GO:0030850 8.8 SHH PTCH1 GLI1

Molecular functions related to Cerebellum Cancer according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 patched binding GO:0005113 8.62 SHH PTCH1

Sources for Cerebellum Cancer

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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