MCID: CRB014
MIFTS: 28

Cerebral Angioma

Categories: Cancer diseases, Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Cerebral Angioma

MalaCards integrated aliases for Cerebral Angioma:

Name: Cerebral Angioma 12 15
Hemangioma of Cerebrum 12
Cerebral Hemangioma 70

Classifications:



External Ids:

Disease Ontology 12 DOID:6621
NCIt 50 C5433
UMLS 70 C0877388

Summaries for Cerebral Angioma

Disease Ontology : 12 A brain angioma that is characterized by vascular abnormalities that develops from cranial and spinal blood vasculature, has material basis in abnormally proliferating cells, derives from endothelial cells in and about the vascular lumen.

MalaCards based summary : Cerebral Angioma, also known as hemangioma of cerebrum, is related to aneurysm and intracranial structure hemangioma. An important gene associated with Cerebral Angioma is KRIT1 (KRIT1 Ankyrin Repeat Containing), and among its related pathways/superpathways are Development_Hedgehog and PTH signaling pathways in bone and cartilage development and Transcription_Role of VDR in regulation of genes involved in osteoporosis. Affiliated tissues include endothelial, brain and liver, and related phenotypes are Increased shRNA abundance (Z-score > 2) and Increased shRNA abundance (Z-score > 2)

Related Diseases for Cerebral Angioma

Diseases related to Cerebral Angioma via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 40)
# Related Disease Score Top Affiliating Genes
1 aneurysm 10.1
2 intracranial structure hemangioma 10.1 PDCD10 KRIT1 CCM2
3 intracranial cavernous angioma 10.1 PDCD10 KRIT1 CCM2
4 hemangioma of liver 10.1 PDCD10 KRIT1 CCM2
5 cerebral cavernous malformation, familial 10.1 PDCD10 KRIT1 CCM2
6 cavernous malformation 10.1 PDCD10 KRIT1 CCM2
7 venous malformations, multiple cutaneous and mucosal 10.1 PDCD10 KRIT1 CCM2
8 cerebral cavernous malformations 10.1 PDCD10 KRIT1 CCM2
9 cerebral cavernous malformations 3 10.1 PDCD10 KRIT1 CCM2
10 cerebral cavernous malformations 2 10.1 PDCD10 KRIT1 CCM2
11 cerebrocostomandibular syndrome 10.1 PDCD10 KRIT1 CCM2
12 cavernous hemangioma 10.0 PDCD10 KRIT1 CCM2
13 weber syndrome 10.0 GNAQ CYP1B1
14 intracranial aneurysm 10.0
15 hemiplegia 10.0
16 brain angioma 10.0 PDCD10 KRIT1 H1-8 CCM2
17 corneal ulcer 9.9 IL1A CYP1B1
18 steroid-induced glaucoma 9.9 NR3C1 CYP1B1
19 sturge-weber syndrome 9.9 GNAQ CYP1B1
20 hemorrhagic disease 9.9 PDCD10 KRIT1 CCM2
21 hyperostosis frontalis interna 9.8
22 ocular motor apraxia 9.8
23 cyanosis, transient neonatal 9.8
24 thrombosis 9.8
25 amnestic disorder 9.8
26 arteriovenous malformation 9.8
27 transient global amnesia 9.8
28 hyperostosis 9.8
29 glioblastoma 9.8
30 oligodendroglioma 9.8
31 choriocarcinoma 9.8
32 intracranial hypertension 9.8
33 klippel-trenaunay-weber syndrome 9.8 PDCD10 KRIT1 GNAQ CCM2
34 hemangioma 9.8 PDCD10 KRIT1 GNAQ CCM2
35 periapical periodontitis 9.7 RUNX2 IL1A
36 keratopathy 9.7 IL1A CYP1B1
37 root resorption 9.6 RUNX2 IL1A
38 vascular disease 9.6 PDCD10 KRIT1 IL1A CCM2 BMP6
39 open-angle glaucoma 9.6 NR3C1 IL1A CYP1B1
40 osteoporosis 9.0 RUNX2 NR3C1 IL1A CNR1 BMP6

Graphical network of the top 20 diseases related to Cerebral Angioma:



Diseases related to Cerebral Angioma

Symptoms & Phenotypes for Cerebral Angioma

GenomeRNAi Phenotypes related to Cerebral Angioma according to GeneCards Suite gene sharing:

26 (show all 37)
# Description GenomeRNAi Source Accession Score Top Affiliating Genes
1 Increased shRNA abundance (Z-score > 2) GR00366-A-109 9.9 GARS1
2 Increased shRNA abundance (Z-score > 2) GR00366-A-11 9.9 BMP6
3 Increased shRNA abundance (Z-score > 2) GR00366-A-111 9.9 NR3C1
4 Increased shRNA abundance (Z-score > 2) GR00366-A-114 9.9 BMP6
5 Increased shRNA abundance (Z-score > 2) GR00366-A-134 9.9 H1-8
6 Increased shRNA abundance (Z-score > 2) GR00366-A-138 9.9 BMP6
7 Increased shRNA abundance (Z-score > 2) GR00366-A-14 9.9 NR3C1
8 Increased shRNA abundance (Z-score > 2) GR00366-A-153 9.9 GARS1
9 Increased shRNA abundance (Z-score > 2) GR00366-A-157 9.9 NR3C1
10 Increased shRNA abundance (Z-score > 2) GR00366-A-16 9.9 H1-8
11 Increased shRNA abundance (Z-score > 2) GR00366-A-165 9.9 GARS1
12 Increased shRNA abundance (Z-score > 2) GR00366-A-173 9.9 GARS1
13 Increased shRNA abundance (Z-score > 2) GR00366-A-175 9.9 H1-8
14 Increased shRNA abundance (Z-score > 2) GR00366-A-176 9.9 H1-8
15 Increased shRNA abundance (Z-score > 2) GR00366-A-177 9.9 H1-8
16 Increased shRNA abundance (Z-score > 2) GR00366-A-18 9.9 NR3C1
17 Increased shRNA abundance (Z-score > 2) GR00366-A-181 9.9 BMP6
18 Increased shRNA abundance (Z-score > 2) GR00366-A-192 9.9 GARS1
19 Increased shRNA abundance (Z-score > 2) GR00366-A-208 9.9 GARS1
20 Increased shRNA abundance (Z-score > 2) GR00366-A-21 9.9 NR3C1
21 Increased shRNA abundance (Z-score > 2) GR00366-A-210 9.9 GARS1
22 Increased shRNA abundance (Z-score > 2) GR00366-A-214 9.9 BMP6 NR3C1
23 Increased shRNA abundance (Z-score > 2) GR00366-A-26 9.9 GARS1
24 Increased shRNA abundance (Z-score > 2) GR00366-A-29 9.9 H1-8
25 Increased shRNA abundance (Z-score > 2) GR00366-A-34 9.9 GARS1
26 Increased shRNA abundance (Z-score > 2) GR00366-A-35 9.9 H1-8
27 Increased shRNA abundance (Z-score > 2) GR00366-A-42 9.9 GARS1
28 Increased shRNA abundance (Z-score > 2) GR00366-A-45 9.9 H1-8
29 Increased shRNA abundance (Z-score > 2) GR00366-A-47 9.9 BMP6
30 Increased shRNA abundance (Z-score > 2) GR00366-A-53 9.9 BMP6
31 Increased shRNA abundance (Z-score > 2) GR00366-A-63 9.9 GARS1
32 Increased shRNA abundance (Z-score > 2) GR00366-A-66 9.9 BMP6
33 Increased shRNA abundance (Z-score > 2) GR00366-A-74 9.9 GARS1
34 Increased shRNA abundance (Z-score > 2) GR00366-A-76 9.9 BMP6
35 Increased shRNA abundance (Z-score > 2) GR00366-A-79 9.9 NR3C1
36 Increased shRNA abundance (Z-score > 2) GR00366-A-92 9.9 GARS1
37 Increased shRNA abundance (Z-score > 2) GR00366-A-95 9.9 BMP6

MGI Mouse Phenotypes related to Cerebral Angioma:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 growth/size/body region MP:0005378 10.02 BMP6 CCM2 CNR1 GARS1 GNAQ KRIT1
2 cardiovascular system MP:0005385 9.97 CCM2 GNAQ IL1A KRIT1 NR3C1 PDCD10
3 integument MP:0010771 9.8 CCM2 CNR1 GNAQ IL1A NR3C1 PDCD10
4 muscle MP:0005369 9.7 CCM2 GARS1 GNAQ KRIT1 NR3C1 PDCD10
5 nervous system MP:0003631 9.61 CCM2 CNR1 GARS1 GNAQ KRIT1 NR3C1
6 normal MP:0002873 9.17 CCM2 CNR1 GARS1 GNAQ H1-8 NR3C1

Drugs & Therapeutics for Cerebral Angioma

Search Clinical Trials , NIH Clinical Center for Cerebral Angioma

Genetic Tests for Cerebral Angioma

Anatomical Context for Cerebral Angioma

MalaCards organs/tissues related to Cerebral Angioma:

40
Endothelial, Brain, Liver

Publications for Cerebral Angioma

Articles related to Cerebral Angioma:

(show top 50) (show all 77)
# Title Authors PMID Year
1
Two cases of familial cerebral cavernous malformation caused by mutations in the CCM1 gene. 61
27462358 2016
2
Anesthetic management of a pregnant patient with cerebral angioma scheduled for caesarean section. 61
26541598 2015
3
[Multiple cerebral cavernomatosis in a 1-year-old child]. 61
20542671 2010
4
[Natural course of the arteriovenous malformations of the brain]. 61
18792582 2008
5
Transient exacerbation of hemiplegia following minor head trauma in Sturge-Weber syndrome. 61
17718827 2007
6
[Asymptomatic brain metastasis of choriocarcinoma mimicking cerebral angioma: a case report]. 61
16519115 2006
7
Bilateral diffuse choroidal hemangiomas with unilateral facial nevus flammeus in Sturge-Weber syndrome. 61
11020422 2000
8
[Sturge-Weber syndrome: differential diagnosis of neurocysticercosis]. 61
10742994 2000
9
Intracerebral haemorrhage from a venous angioma following thrombosis of a draining vein. 61
9493181 1998
10
[Cavernous cerebral angioma: indications for neurosurgical removal]. 61
9005329 1996
11
[Cerebrovascular abnormalities in pregnancy]. 61
7668070 1995
12
Flow velocity and pressure measurements in spinal dural arteriovenous fistulas. 61
8078606 1994
13
Labetalol as prophylaxis of cardiovascular instability after cerebral angioma surgery. 61
8177416 1993
14
[Peridural anesthesia for cesarean section in a patient with inoperable cerebral angioma]. 61
8474678 1993
15
Stereotaxic irradiation of 46 cases of cerebral angioma. 61
1560887 1992
16
[A case of cerebral angioma: non-invasive instrumental diagnosis]. 61
2100047 1990
17
Regional cerebral blood flow by SPECT imaging in Sturge-Weber disease: an aid for diagnosis. 61
2614436 1989
18
[Stereotactic single-dose irradiation of cerebral angioma]. 61
2498989 1989
19
Hemodynamics of spinal dural arteriovenous fistulas. An intraoperative study. 61
2492595 1989
20
Mitochondrial myopathies with necrotizing encephalopathy of the Leigh type. 61
3222173 1988
21
[Rupture of a cerebral angioma in pregnancy]. 61
3678799 1987
22
[Unilateral hyperostosis frontalis interna coexistent with cerebral angioma]. 61
3670532 1987
23
[Cerebral angioma disclosed by 2 episodes of transient global amnesia]. 61
2942881 1986
24
Cerebral haemorrhage in arteriovenous malformation associated with Klippel-Trenaunay syndrome. 61
3005520 1986
25
The management of cerebral arteriovenous malformations. 61
3976444 1985
26
[Cerebral abscesses disclosing pulmonary angioma. Rendu-Osler disease]. 61
6231629 1984
27
[The image of cerebral angioma in computerized tomography]. 61
6728110 1984
28
Phonocephalography and pulsatile tinnitus in a surface cerebral angioma. Report of a case. 61
6619657 1983
29
Possible significance of juvenile oral venous angioma as marker of intracerebral vascular lesion. 61
6864304 1983
30
Homologous controlled-viscosity fibrin for endovascular embolization. Part II: catheterization technique, animal experiments. 61
7124468 1982
31
[Sudden death of children by hemorrhage from a cerebral angioma (author's transl)]. 61
574582 1979
32
[The clinical picture, motor activity, electro-encephalographic, neurophysiologic and linguistic findings in a case of left-sided hemispherectomy (author's transl)]. 61
1047658 1976
33
Intra-operative angiography in cerebral angioma and aneurysm surgery. 61
207112 1976
34
Cerebral angioma and aneurysm of the cervical internal carotid artery. 61
1053581 1975
35
Surgical relief for premature closure of fontanelles due to cerebral angioma--a case report. 61
1053604 1975
36
[Simplified measurement of blood flow in cerebral angioma]. 61
1186955 1975
37
Small strokes in the carotid territory associated with a normal carotid arteriogram. 61
4647853 1972
38
[Clinico-radiological study of a case of artero-venous cerebral angioma with an infratentorial location]. 61
5608896 1967
39
[Radiographic picture of parasagittal cerebral angioma]. 61
5911124 1966
40
[Can an arteriovenous cerebral angioma cause a stenosis of the aqueduct?]. 61
5880123 1965
41
[ASSOCIATED RETINAL CYANOSIS, BILATERAL RETINAL CYST, PROBABLE CEREBRAL ANGIOMA]. 61
14302026 1964
42
[CEREBRAL ANGIOMA. SPONTANEOUS THROMBOSIS (APROPOS OF 1 CASE)]. 61
14306050 1964
43
[PARINAUD'S SYNDROME AND CEREBRAL ANGIOMA]. 61
14297432 1964
44
[PARINAUD'S SYNDROME AND CEREBRAL ANGIOMA]. 61
14103110 1963
45
[Unusually large saccular aneurysm of the basilar artery as an accidental finding in cerebral angioma]. 61
14001691 1963
46
[Cerebral angioma. Surgical indications. Technic and results]. 61
13861709 1962
47
[Clinical manifestations of cerebral angioma]. 61
14493674 1962
48
[Cerebral angioma in children]. 61
13937179 1962
49
[Cerebral angioma]. 61
13955285 1962
50
Surgical treatment of cerebral angioma and aneurysm. 61
13709165 1961

Variations for Cerebral Angioma

Expression for Cerebral Angioma

Search GEO for disease gene expression data for Cerebral Angioma.

Pathways for Cerebral Angioma

Pathways related to Cerebral Angioma according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 10.75 RUNX2 GNAQ
2 10.45 RUNX2 NR3C1 IL1A
3 10.07 GNAQ CNR1

GO Terms for Cerebral Angioma

Cellular components related to Cerebral Angioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cytoplasm GO:0005737 9.36 RUNX2 PDCD10 NR3C1 KRIT1 IL1A H1-8

Biological processes related to Cerebral Angioma according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 cellular response to BMP stimulus GO:0071773 9.32 RUNX2 BMP6
2 endochondral ossification GO:0001958 9.26 RUNX2 BMP6
3 positive regulation of gene expression GO:0010628 9.26 RUNX2 PDCD10 IL1A BMP6
4 positive regulation of vascular endothelial growth factor production GO:0010575 9.16 IL1A CYP1B1
5 positive regulation of chondrocyte differentiation GO:0032332 8.62 RUNX2 BMP6

Sources for Cerebral Angioma

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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