MCID: CRB031
MIFTS: 28

Cerebral Arterial Disease

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Cerebral Arterial Disease

MalaCards integrated aliases for Cerebral Arterial Disease:

Name: Cerebral Arterial Disease 12 15
Cerebral Arterial Diseases 44 73

Classifications:



External Ids:

Disease Ontology 12 DOID:3527
MeSH 44 D002539
UMLS 73 C0007774

Summaries for Cerebral Arterial Disease

MalaCards based summary : Cerebral Arterial Disease, also known as cerebral arterial diseases, is related to moyamoya disease 1 and aortic aneurysm. An important gene associated with Cerebral Arterial Disease is RNF213 (Ring Finger Protein 213), and among its related pathways/superpathways are G-protein signaling Regulation of p38 and JNK signaling mediated by G-proteins and Cell adhesion_Cell-matrix glycoconjugates. The drugs Abciximab and Piracetam have been mentioned in the context of this disorder. Affiliated tissues include brain, and related phenotype is hematopoietic system.

Related Diseases for Cerebral Arterial Disease

Graphical network of the top 20 diseases related to Cerebral Arterial Disease:



Diseases related to Cerebral Arterial Disease

Symptoms & Phenotypes for Cerebral Arterial Disease

MGI Mouse Phenotypes related to Cerebral Arterial Disease:

46
# Description MGI Source Accession Score Top Affiliating Genes
1 hematopoietic system MP:0005397 9.23 ASAH1 GUCY1A1 MMP9 MRAS NF1 RPSA

Drugs & Therapeutics for Cerebral Arterial Disease

Drugs for Cerebral Arterial Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 78)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abciximab Approved Phase 4 143653-53-6
2 Piracetam Approved, Investigational Phase 4 7491-74-9
3 Calcium, Dietary Phase 4
4 Lipid Regulating Agents Phase 4,Not Applicable
5 Anticholesteremic Agents Phase 4
6 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Not Applicable
7 Rosuvastatin Calcium Phase 4 147098-20-2
8 Antimetabolites Phase 4,Not Applicable
9 Hypolipidemic Agents Phase 4,Not Applicable
10 Tissue Plasminogen Activator Phase 4,Phase 3,Phase 2,Not Applicable
11 Anticoagulants Phase 4,Phase 2,Not Applicable
12 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Not Applicable
13 Platelet Aggregation Inhibitors Phase 4,Phase 3,Not Applicable
14 Plasminogen Phase 4,Phase 2,Not Applicable
15 Pharmaceutical Solutions Phase 4,Phase 2
16 Antibodies Phase 4
17 Immunoglobulins Phase 4
18 Immunoglobulin Fab Fragments Phase 4
19 Antibodies, Monoclonal Phase 4
20 Immunologic Factors Phase 4
21
Clopidogrel Approved Phase 3 113665-84-2, 120202-66-6 60606
22
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
23
Ticlopidine Approved Phase 3 55142-85-3 5472
24
Sevoflurane Approved, Vet_approved Phase 3,Not Applicable 28523-86-6 5206
25
Xylometazoline Approved, Investigational Phase 3,Not Applicable 526-36-3 5709
26
Propofol Approved, Investigational, Vet_approved Phase 3 2078-54-8 4943
27
Esmolol Approved Phase 3 103598-03-4, 81147-92-4 59768
28
Mannitol Approved, Investigational Phase 3,Not Applicable 69-65-8 453 6251
29 Analgesics, Non-Narcotic Phase 3
30 Purinergic P2Y Receptor Antagonists Phase 3
31 Analgesics Phase 3
32 Cytochrome P-450 Enzyme Inhibitors Phase 3
33 Peripheral Nervous System Agents Phase 3
34 Cytochrome P-450 CYP2C19 Inhibitors Phase 3
35 Anti-Inflammatory Agents, Non-Steroidal Phase 3
36 Purinergic P2 Receptor Antagonists Phase 3
37 Antirheumatic Agents Phase 3
38 Cyclooxygenase Inhibitors Phase 3
39 Neurotransmitter Agents Phase 3,Phase 2
40 Antipyretics Phase 3
41 Anti-Inflammatory Agents Phase 3
42 Anesthetics Phase 3,Phase 1,Phase 2,Not Applicable
43 Central Nervous System Depressants Phase 3,Not Applicable
44 Anesthetics, Inhalation Phase 3,Not Applicable
45 Anesthetics, General Phase 3,Not Applicable
46 Hypnotics and Sedatives Phase 3
47 Adrenergic Agents Phase 3
48 Anesthetics, Intravenous Phase 3
49 Adrenergic Antagonists Phase 3
50 Adrenergic beta-Antagonists Phase 3

Interventional clinical trials:

(show top 50) (show all 78)
# Name Status NCT ID Phase Drugs
1 Effect of Rosuvastatin on Prognosis of Clinical Response in Acute Ischemic Stroke Patients(REPAIRS) Unknown status NCT02484027 Phase 4 Rosuvastatin
2 Thrombectomy Under Reopro Versus Alteplase to Treat Stoke Terminated NCT02016547 Phase 4 alteplase 0.9mg/kg (10% by IV bolus following by 90% by 1 hour IV drip)
3 A Study to Evaluate the Efficacy and Safety of Piracetam on Aphasia After Acute Ischemic Cerebral Artery Stroke Terminated NCT01883011 Phase 4 Piracetam
4 The Carotid and Middle Cerebral Artery Occlusion Surgery Study Unknown status NCT01758614 Phase 3 Aspirin;Clopidogrel
5 Ultrasound Enhanced Thrombolytic Therapy of Middle Cerebral Artery Occlusion Unknown status NCT00336596 Phase 3
6 Carotid and Vertebral Magnetic Resonance Angiography (MRA) Study Comparing Dotarem and Time Of Flight (TOF) Completed NCT01012674 Phase 3 Dotarem
7 Carotid and Vertebral Magnetic Resonance Angiography (MRA) Study Comparing Dotarem and Time Of Flight (TOF) Completed NCT01010932 Phase 3 Dotarem
8 Esmolol Infusion in Patients Undergoing Craniotomy Completed NCT02455440 Phase 3 Esmolol;Placebo;Propofol and sevoflurane
9 Multicenter Efficacy Study of Recombinant Human Erythropoietin in Acute Ischemic Stroke Completed NCT00604630 Phase 2, Phase 3 recombinant human erythropoietin alfa;0.9% NaCl
10 Application of Amyloid PET in Cerebral Amyloid Angiopathy Recruiting NCT03542656 Phase 3 amyloid PET
11 The Adult Hemorrhagic Moyamoya Surgery Study Active, not recruiting NCT02319980 Phase 3
12 Hemicraniectomy for Malignant Middle Cerebral Artery Infarction (HeMMI): A Single Center Randomized Controlled Clinical Trial Terminated NCT02002234 Phase 3
13 Decompressive Craniectomy In Malignant Middle Cerebral Artery Infarcts Terminated NCT00190203 Phase 3
14 Autologous Bone Marrow Stromal Cell and Endothelial Progenitor Cell Transplantation in Ischemic Stroke Unknown status NCT01468064 Phase 1, Phase 2
15 Intravenous Autologous Mesenchymal Stem Cells Transplantation to Treat Middle Cerebral Artery Infarct Unknown status NCT01461720 Phase 2
16 Safety Study of Dabigatran in CADASIL Unknown status NCT01361763 Phase 2 Dabigatran;Antiplatelets
17 Study Evaluating the Safety,Tolerability and Efficacy of PF-04360365 in Adults With Probable Cerebral Amyloid Angiopathy Completed NCT01821118 Phase 2
18 Multiple Burrhole Therapy With Erythropoietin for Unstable Moyamoya Completed NCT03162588 Phase 1, Phase 2 erythropoietin
19 Cerebrilâ„¢ in Patients With Lobar Hemorrhage Related to Cerebral Amyloid Angiopathy Completed NCT00056238 Phase 2 NC-758 (Anti amyloidotic [Aß] agent)
20 Stem Cell Therapy For Acute Ischemic Stroke Patients Completed NCT02425670 Phase 2
21 Efficacy Study of CD34 Stem Cell in Chronic Stroke Patients Completed NCT00950521 Phase 2 convention therapy
22 Thrombolysis and Deferoxamine in Middle Cerebral Artery Occlusion Completed NCT00777140 Phase 2 Deferoxamine
23 Autologous Bone Marrow Stem Cells in Middle Cerebral Artery Acute Stroke Treatment. Completed NCT00761982 Phase 1, Phase 2
24 Autologous Bone Marrow Stem Cells in Ischemic Stroke. Completed NCT00535197 Phase 1, Phase 2
25 The Efficacy, Safety, And Tolerability Of Donepezil HCl (E2020) In Patients With CADASIL Who Have Cognitive Impairment Completed NCT00103948 Phase 2 Aricept
26 Study of Human Placenta-derived Cells (PDA001) to Evaluate the Safety and Effectiveness for Patients With Ischemic Stroke Terminated NCT01310114 Phase 2 Placebo
27 The Efficacy and Safety of MK0724 IV for Improvement of Neurological Damage and Recovery From Middle Cerebral Artery Ischemic Stroke (0724-018) Terminated NCT00401310 Phase 2 Comparator: Placebo;Comparator: MK0724
28 Superiority of Rt-PA + Tenecteplase in Comparison With Rt-PA Only in Proximal Middle Cerebral Artery Occlusion Withdrawn NCT02338466 Phase 2 rt-PA;tenecteplase
29 Study of Purified Umbilical Cord Blood CD34+ Stem Cell on Chronic Ischemic Stroke Unknown status NCT01438593 Phase 1
30 Implantation of Olfactory Ensheathing Cells (OECs) Unknown status NCT01327768 Phase 1
31 Intraarterial Stem Cells in Subacute Ischemic Stroke Completed NCT03080571 Phase 1
32 Study of Autologous Stem Cell Transplantation for Patients With Ischemic Stroke Completed NCT00473057 Phase 1
33 Prospective Observation for Serial Changes of Acute Intracranial Artery Dissection Using High Resolution MRI Unknown status NCT02914288
34 Direct Bypass Versus Indirect Bypass in Treatment of Adults Hemorrhagic Moyamoya Disease Unknown status NCT02982135 Not Applicable
35 Characteristics and Outcomes of Childhood Moyamoya in the UK Unknown status NCT02434302
36 Sevoflurane and Hyperperfusion Syndrome Unknown status NCT02510586 Not Applicable Sevoflurane
37 Methods of Etiological Diagnosis of Cerebral Amyloid Angiopathy Unknown status NCT02361411
38 Subclavian Vein catheterization_Seldinger Vs Modified Seldinger Unknown status NCT02090010 Not Applicable
39 Imaging Study of Neurovascular Coupling in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Unknown status NCT02071784
40 Generation of a Cellular Model of CADASIL From Skin Fibroblasts Unknown status NCT02032225
41 Normal Values of Brain Oxygenation Completed NCT00512447
42 Longitudinal Study of Neurologic, Cognitive, and Radiologic Outcomes of PHACE Syndrome Completed NCT01018082
43 Pulse Wave Velocity as a Predictor for Postoperative Cardiovascular Events Completed NCT03223441
44 Dual-Task Training With Different Priority Instructional Sets on the Gait Parameters in Patients With Chronic Stroke Completed NCT03752788 Not Applicable
45 Intracranial Pressure After Decompressive Craniectomy Completed NCT03364634
46 Effects of Remote Ischemic Preconditioning With Postconditioning on Neurologic Outcome Completed NCT03072914 Not Applicable
47 The Silent Cortical Infarcts in the Cerebral Amyloid Angiopathy: Is There a Link With Subarachnoid Hemorrhage? Completed NCT02837354
48 A Comparison Between Two Techniques for Performing Decompressive Craniectomy Completed NCT02594137 Not Applicable
49 Impact of tDCS on Cerebral Autoregulation Completed NCT01865604 Not Applicable
50 Quantifying Collateral Perfusion in Cerebrovascular Disease-Moyamoya Disease and Stroke Patients Completed NCT01419275 Not Applicable Xenon contrast agent

Search NIH Clinical Center for Cerebral Arterial Disease

Cochrane evidence based reviews: cerebral arterial diseases

Genetic Tests for Cerebral Arterial Disease

Anatomical Context for Cerebral Arterial Disease

MalaCards organs/tissues related to Cerebral Arterial Disease:

41
Brain

Publications for Cerebral Arterial Disease

Articles related to Cerebral Arterial Disease:

(show all 13)
# Title Authors Year
1
Frequency and Risk Factors for Cerebral Arterial Disease in a HIV/AIDS Neuroimaging Cohort. ( 26751784 )
2016
2
Associations of ankle-brachial index (ABI) with cerebral arterial disease and vascular events following ischemic stroke. ( 22652527 )
2012
3
Assessment of pial branches using 7-tesla MRI in cerebral arterial disease. ( 20185908 )
2010
4
Risk factors for stroke in different levels of cerebral arterial disease. ( 10529541 )
1999
5
High prevalence of unsuspected abdominal aortic aneurysm in patients with confirmed symptomatic peripheral or cerebral arterial disease. ( 8518892 )
1993
6
Basis for an international classification of cerebral arterial diseases. ( 3488419 )
1986
7
Occlusive cerebral arterial disease. ( 6839323 )
1983
8
Intracranial bypass surgery for cerebral arterial disease and the responsibility of the practicing physician. ( 462524 )
1979
9
Effect of ethyl apovincaminate on the cerebral circulation. Studies in patients with obliterative cerebral arterial disease. ( 1037221 )
1976
10
Cerebral arterial disease in children. An angiographic study of 40 cases. ( 5579392 )
1971
11
The significance of naturally occurring coronary and cerebral arterial disease in animals. ( 5253796 )
1968
12
Cerebral arterial disease. ( 14430850 )
1959
13
Cerebral arterial disease. ( 14417991 )
1959

Variations for Cerebral Arterial Disease

Expression for Cerebral Arterial Disease

Search GEO for disease gene expression data for Cerebral Arterial Disease.

Pathways for Cerebral Arterial Disease

Pathways related to Cerebral Arterial Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1
Show member pathways
11.36 ACTA2 ELN MMP9 MRAS
2 10.21 ELN MMP9

GO Terms for Cerebral Arterial Disease

Biological processes related to Cerebral Arterial Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular matrix organization GO:0030198 9.13 ELN MMP9 NF1
2 blood circulation GO:0008015 8.62 ELN GUCY1A1

Sources for Cerebral Arterial Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
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