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MCID: CRB031
MIFTS: 28

Cerebral Arterial Disease

Categories: Cardiovascular diseases, Neuronal diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Cerebral Arterial Disease

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MalaCards integrated aliases for Cerebral Arterial Disease:

Name: Cerebral Arterial Disease 12 15 17
Cerebral Arterial Diseases 45 74

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3527
MeSH 45 D002539
UMLS 74 C0007774
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Summaries for Cerebral Arterial Disease

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MalaCards based summary : Cerebral Arterial Disease, also known as cerebral arterial diseases, is related to moyamoya disease 1 and aortic aneurysm. An important gene associated with Cerebral Arterial Disease is RNF213 (Ring Finger Protein 213). The drugs Abciximab and Calcium have been mentioned in the context of this disorder. Affiliated tissues include bone, brain and bone marrow.

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Related Diseases for Cerebral Arterial Disease

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Diseases related to Cerebral Arterial Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 20)
# Related Disease Score Top Affiliating Genes
1 moyamoya disease 1 31.3 ACTA2 GUCY1A1 NF1 PCLO RNF213 RPSA
2 aortic aneurysm 29.0 ACTA2 CDKN2B-AS1 ELN
3 stroke, ischemic 10.5
4 cerebral atherosclerosis 10.3 RNF213 RPSA
5 tolosa-hunt syndrome 10.2 NF1 RPSA
6 subclavian artery aneurysm 10.2 NF1 SLC25A16
7 arteries, anomalies of 10.1
8 vertebral artery occlusion 10.0 MRAS SLC25A16
9 elephantiasis 10.0 ELN NF1
10 aortic aneurysm, familial thoracic 1 9.9 ACTA2 ELN
11 plexiform neurofibroma 9.8 CDKN2B-AS1 NF1
12 neurofibromatosis, type i 9.8 CDKN2B-AS1 NF1
13 aortic aneurysm, familial abdominal, 1 9.7
14 osteoporosis 9.7
15 human immunodeficiency virus type 1 9.7
16 bone mineral density quantitative trait locus 8 9.7
17 bone mineral density quantitative trait locus 15 9.7
18 carotid stenosis 9.7
19 arteriovenous malformations of the brain 9.4 CDKN2B-AS1 SOX17
20 intracranial aneurysm 9.3 CDKN2B-AS1 ELN SOX17 THSD1

Graphical network of the top 20 diseases related to Cerebral Arterial Disease:



Diseases related to Cerebral Arterial Disease
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Symptoms & Phenotypes for Cerebral Arterial Disease

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Drugs & Therapeutics for Cerebral Arterial Disease

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Drugs for Cerebral Arterial Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 74)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abciximab Approved Phase 4 143653-53-6
2
Calcium Approved, Nutraceutical Phase 4 7440-70-2 271
3 Rosuvastatin Calcium Phase 4 147098-20-2
4 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Not Applicable
5 Antimetabolites Phase 4
6 Anticholesteremic Agents Phase 4
7 Hypolipidemic Agents Phase 4
8 Calcium, Dietary Phase 4
9 Lipid Regulating Agents Phase 4
10 Anticoagulants Phase 4,Phase 2
11 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Not Applicable
12 Tissue Plasminogen Activator Phase 4,Phase 3,Phase 2,Not Applicable
13 Platelet Aggregation Inhibitors Phase 4,Phase 3,Not Applicable
14 Plasminogen Phase 4,Phase 2,Not Applicable
15 Pharmaceutical Solutions Phase 4,Phase 2,Not Applicable
16
Clopidogrel Approved Phase 3 120202-66-6, 113665-84-2 60606
17
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
18
Sevoflurane Approved, Vet_approved Phase 3,Not Applicable 28523-86-6 5206
19
Xylometazoline Approved, Investigational Phase 3,Not Applicable 526-36-3 5709
20
Esmolol Approved Phase 3 103598-03-4, 81147-92-4 59768
21
Propofol Approved, Investigational, Vet_approved Phase 3 2078-54-8 4943
22
Mannitol Approved, Investigational Phase 3,Not Applicable 69-65-8 6251 453
23 Antipyretics Phase 3
24 Peripheral Nervous System Agents Phase 3
25 Purinergic P2Y Receptor Antagonists Phase 3
26 Cyclooxygenase Inhibitors Phase 3
27 Neurotransmitter Agents Phase 3,Phase 2
28 Anti-Inflammatory Agents Phase 3
29 Antirheumatic Agents Phase 3
30 Analgesics, Non-Narcotic Phase 3
31 Analgesics Phase 3
32 Anti-Inflammatory Agents, Non-Steroidal Phase 3
33 Purinergic P2 Receptor Antagonists Phase 3
34 Anesthetics Phase 3,Phase 1,Phase 2,Not Applicable
35 Anesthetics, Inhalation Phase 3,Not Applicable
36 Central Nervous System Depressants Phase 3,Not Applicable
37 Anesthetics, General Phase 3,Not Applicable
38 Anesthetics, Intravenous Phase 3
39 Adrenergic Agents Phase 3
40 Adrenergic beta-Antagonists Phase 3
41 Adrenergic beta-1 Receptor Antagonists Phase 3
42 Adrenergic Antagonists Phase 3
43 Hypnotics and Sedatives Phase 3
44 Epoetin alfa Phase 2, Phase 3,Phase 1,Not Applicable 113427-24-0
45 Hematinics Phase 2, Phase 3,Phase 1,Not Applicable
46
Deferoxamine Approved, Investigational Phase 2 70-51-9 2973
47
Iron Approved, Experimental Phase 2 7439-89-6, 15438-31-0 27284 23925
48
Donepezil Approved Phase 2 120014-06-4 3152
49
Serine Approved, Nutraceutical Phase 2 56-45-1 5951
50
Dabigatran Investigational Phase 2 211914-51-1

Interventional clinical trials:

(show top 50) (show all 81)
# Name Status NCT ID Phase Drugs
1 Effect of Rosuvastatin on Prognosis of Clinical Response in Acute Ischemic Stroke Patients(REPAIRS) Unknown status NCT02484027 Phase 4 Rosuvastatin
2 Thrombectomy Under Reopro Versus Alteplase to Treat Stoke Terminated NCT02016547 Phase 4 alteplase 0.9mg/kg (10% by IV bolus following by 90% by 1 hour IV drip)
3 A Study to Evaluate the Efficacy and Safety of Piracetam on Aphasia After Acute Ischemic Cerebral Artery Stroke Terminated NCT01883011 Phase 4 Piracetam
4 The Carotid and Middle Cerebral Artery Occlusion Surgery Study Unknown status NCT01758614 Phase 3 Aspirin;Clopidogrel
5 Ultrasound Enhanced Thrombolytic Therapy of Middle Cerebral Artery Occlusion Unknown status NCT00336596 Phase 3
6 Carotid and Vertebral Magnetic Resonance Angiography (MRA) Study Comparing Dotarem and Time Of Flight (TOF) Completed NCT01012674 Phase 3 Dotarem
7 Carotid and Vertebral Magnetic Resonance Angiography (MRA) Study Comparing Dotarem and Time Of Flight (TOF) Completed NCT01010932 Phase 3 Dotarem
8 Esmolol Infusion in Patients Undergoing Craniotomy Completed NCT02455440 Phase 3 Esmolol;Placebo;Propofol and sevoflurane
9 Multicenter Efficacy Study of Recombinant Human Erythropoietin in Acute Ischemic Stroke Completed NCT00604630 Phase 2, Phase 3 recombinant human erythropoietin alfa;0.9% NaCl
10 Application of Amyloid PET in Cerebral Amyloid Angiopathy Recruiting NCT03542656 Phase 3 amyloid PET
11 The Adult Hemorrhagic Moyamoya Surgery Study Active, not recruiting NCT02319980 Phase 3
12 Hemicraniectomy for Malignant Middle Cerebral Artery Infarction (HeMMI): A Single Center Randomized Controlled Clinical Trial Terminated NCT02002234 Phase 3
13 Decompressive Craniectomy In Malignant Middle Cerebral Artery Infarcts Terminated NCT00190203 Phase 3
14 Autologous Bone Marrow Stromal Cell and Endothelial Progenitor Cell Transplantation in Ischemic Stroke Unknown status NCT01468064 Phase 1, Phase 2
15 Intravenous Autologous Mesenchymal Stem Cells Transplantation to Treat Middle Cerebral Artery Infarct Unknown status NCT01461720 Phase 2
16 Safety Study of Dabigatran in CADASIL Unknown status NCT01361763 Phase 2 Dabigatran;Antiplatelets
17 Study Evaluating the Safety,Tolerability and Efficacy of PF-04360365 in Adults With Probable Cerebral Amyloid Angiopathy Completed NCT01821118 Phase 2
18 Multiple Burrhole Therapy With Erythropoietin for Unstable Moyamoya Completed NCT03162588 Phase 1, Phase 2 erythropoietin
19 Cerebrilâ„¢ in Patients With Lobar Hemorrhage Related to Cerebral Amyloid Angiopathy Completed NCT00056238 Phase 2 NC-758 (Anti amyloidotic [Aß] agent)
20 Stem Cell Therapy For Acute Ischemic Stroke Patients Completed NCT02425670 Phase 2
21 Efficacy Study of CD34 Stem Cell in Chronic Stroke Patients Completed NCT00950521 Phase 2 convention therapy
22 Thrombolysis and Deferoxamine in Middle Cerebral Artery Occlusion Completed NCT00777140 Phase 2 Deferoxamine
23 Autologous Bone Marrow Stem Cells in Middle Cerebral Artery Acute Stroke Treatment. Completed NCT00761982 Phase 1, Phase 2
24 Autologous Bone Marrow Stem Cells in Ischemic Stroke. Completed NCT00535197 Phase 1, Phase 2
25 The Efficacy, Safety, And Tolerability Of Donepezil HCl (E2020) In Patients With CADASIL Who Have Cognitive Impairment Completed NCT00103948 Phase 2 Aricept
26 Study of Human Placenta-derived Cells (PDA001) to Evaluate the Safety and Effectiveness for Patients With Ischemic Stroke Terminated NCT01310114 Phase 2 Placebo
27 The Efficacy and Safety of MK0724 IV for Improvement of Neurological Damage and Recovery From Middle Cerebral Artery Ischemic Stroke (0724-018) Terminated NCT00401310 Phase 2 Comparator: Placebo;Comparator: MK0724
28 Superiority of Rt-PA + Tenecteplase in Comparison With Rt-PA Only in Proximal Middle Cerebral Artery Occlusion Withdrawn NCT02338466 Phase 2 rt-PA;tenecteplase
29 Study of Purified Umbilical Cord Blood CD34+ Stem Cell on Chronic Ischemic Stroke Unknown status NCT01438593 Phase 1
30 Implantation of Olfactory Ensheathing Cells (OECs) Unknown status NCT01327768 Phase 1
31 Intraarterial Stem Cells in Subacute Ischemic Stroke Completed NCT03080571 Phase 1
32 Study of Autologous Stem Cell Transplantation for Patients With Ischemic Stroke Completed NCT00473057 Phase 1
33 Prospective Observation for Serial Changes of Acute Intracranial Artery Dissection Using High Resolution MRI Unknown status NCT02914288
34 Direct Bypass Versus Indirect Bypass in Treatment of Adults Hemorrhagic Moyamoya Disease Unknown status NCT02982135 Not Applicable
35 Characteristics and Outcomes of Childhood Moyamoya in the UK Unknown status NCT02434302
36 Sevoflurane and Hyperperfusion Syndrome Unknown status NCT02510586 Not Applicable Sevoflurane
37 Methods of Etiological Diagnosis of Cerebral Amyloid Angiopathy Unknown status NCT02361411
38 Subclavian Vein catheterization_Seldinger Vs Modified Seldinger Unknown status NCT02090010 Not Applicable
39 Imaging Study of Neurovascular Coupling in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Unknown status NCT02071784
40 Generation of a Cellular Model of CADASIL From Skin Fibroblasts Unknown status NCT02032225
41 Normal Values of Brain Oxygenation Completed NCT00512447
42 Longitudinal Study of Neurologic, Cognitive, and Radiologic Outcomes of PHACE Syndrome Completed NCT01018082
43 Pulse Wave Velocity as a Predictor for Postoperative Cardiovascular Events Completed NCT03223441
44 Dual-Task Training With Different Priority Instructional Sets on the Gait Parameters in Patients With Chronic Stroke Completed NCT03752788 Not Applicable
45 Intracranial Pressure After Decompressive Craniectomy Completed NCT03364634
46 Modulating Interaction of Motor Learning Networks in Rehabilitation of Stroke Completed NCT03086551 Not Applicable
47 Effects of Remote Ischemic Preconditioning With Postconditioning on Neurologic Outcome Completed NCT03072914 Not Applicable
48 The Silent Cortical Infarcts in the Cerebral Amyloid Angiopathy: Is There a Link With Subarachnoid Hemorrhage? Completed NCT02837354
49 A Comparison Between Two Techniques for Performing Decompressive Craniectomy Completed NCT02594137 Not Applicable
50 Impact of tDCS on Cerebral Autoregulation Completed NCT01865604 Not Applicable

Search NIH Clinical Center for Cerebral Arterial Disease

Cochrane evidence based reviews: cerebral arterial diseases

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Genetic Tests for Cerebral Arterial Disease

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Anatomical Context for Cerebral Arterial Disease

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MalaCards organs/tissues related to Cerebral Arterial Disease:

42
Bone, Brain, Bone Marrow, Endothelial, Skin
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Publications for Cerebral Arterial Disease

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Articles related to Cerebral Arterial Disease:

(show all 13)
# Title Authors Year
1
Frequency and Risk Factors for Cerebral Arterial Disease in a HIV/AIDS Neuroimaging Cohort. ( 26751784 )
2016
2
Associations of ankle-brachial index (ABI) with cerebral arterial disease and vascular events following ischemic stroke. ( 22652527 )
2012
3
Assessment of pial branches using 7-tesla MRI in cerebral arterial disease. ( 20185908 )
2010
4
Risk factors for stroke in different levels of cerebral arterial disease. ( 10529541 )
1999
5
High prevalence of unsuspected abdominal aortic aneurysm in patients with confirmed symptomatic peripheral or cerebral arterial disease. ( 8518892 )
1993
6
Basis for an international classification of cerebral arterial diseases. ( 3488419 )
1986
7
Occlusive cerebral arterial disease. ( 6839323 )
1983
8
Intracranial bypass surgery for cerebral arterial disease and the responsibility of the practicing physician. ( 462524 )
1979
9
Effect of ethyl apovincaminate on the cerebral circulation. Studies in patients with obliterative cerebral arterial disease. ( 1037221 )
1976
10
Cerebral arterial disease in children. An angiographic study of 40 cases. ( 5579392 )
1971
11
The significance of naturally occurring coronary and cerebral arterial disease in animals. ( 5253796 )
1968
12
Cerebral arterial disease. ( 14417991 )
1959
13
Cerebral arterial disease. ( 14430850 )
1959
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Variations for Cerebral Arterial Disease

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Expression for Cerebral Arterial Disease

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Search GEO for disease gene expression data for Cerebral Arterial Disease.
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Pathways for Cerebral Arterial Disease

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GO Terms for Cerebral Arterial Disease

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Biological processes related to Cerebral Arterial Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood circulation GO:0008015 8.62 ELN GUCY1A1
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Sources for Cerebral Arterial Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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