MCID: CRB031
MIFTS: 35

Cerebral Arterial Disease

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Cerebral Arterial Disease

MalaCards integrated aliases for Cerebral Arterial Disease:

Name: Cerebral Arterial Disease 12 15 17
Cerebral Arterial Diseases 44 70

Classifications:



External Ids:

Disease Ontology 12 DOID:3527
MeSH 44 D002539
UMLS 70 C0007774

Summaries for Cerebral Arterial Disease

MalaCards based summary : Cerebral Arterial Disease, also known as cerebral arterial diseases, is related to moyamoya disease 1 and cerebrovascular disease. An important gene associated with Cerebral Arterial Disease is SERPINA3 (Serpin Family A Member 3), and among its related pathways/superpathways are MicroRNAs in cancer and Lung fibrosis. The drugs Esmolol and Propofol have been mentioned in the context of this disorder. Affiliated tissues include heart, kidney and bone.

Related Diseases for Cerebral Arterial Disease

Diseases related to Cerebral Arterial Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 170)
# Related Disease Score Top Affiliating Genes
1 moyamoya disease 1 31.9 RNF213 PLG MMP9 ELN ACTA2
2 cerebrovascular disease 30.4 SERPINA3 MMP9 MIR199A1 ACTA2
3 aortic aneurysm 30.1 MMP9 MIR145 ELN CDKN2B-AS1 ACTA2
4 intracranial aneurysm 29.8 PKD1 NOS3 MIR145 MIR143 ELN CDKN2B-AS1
5 vascular disease 29.6 PLG NOS3 MMP9 MIR199A1 MIR145 MIR143
6 aortic aneurysm, familial abdominal, 1 29.5 SERPINA3 PLG NOS3 MMP9 MIR199A1 MIR181A1
7 esophagus adenocarcinoma 10.4 MIR199A1 MIR145 MIR143
8 aneurysm 10.4 ELN CDKN2B-AS1 ACTA2
9 chronic actinic dermatitis 10.4 MMP9 ELN
10 pre-malignant neoplasm 10.4 SERPINA3 MIR181A1 MIR143
11 cervix small cell carcinoma 10.4 MIR199A1 MIR145 MIR143 MIR125B1
12 uveal disease 10.4 SERPINA3 MIR199A1 MIR125A
13 testicular disease 10.4 SERPINA3 MIR199A1 MIR181A1
14 in situ carcinoma 10.4 SERPINA3 MIR181A1 MIR143
15 intestinal benign neoplasm 10.4 SERPINA3 MIR199A1 MIR145 MIR143
16 breast carcinoma in situ 10.4 SERPINA3 MIR181A1 MIR143
17 multicystic dysplastic kidney 10.4 PKD2 PKD1
18 pleural disease 10.4 MIR199A1 MIR125B1 MIR125A
19 ovarian serous carcinoma 10.4 MIR199A1 MIR145 MIR143 MIR125A
20 mitral valve stenosis 10.4 SERPINA3 PLG EDN1
21 suppression of tumorigenicity 12 10.4 SERPINA3 MIR199A1 MIR145
22 gastrointestinal system benign neoplasm 10.4 SERPINA3 MIR199A1 MIR143
23 gallbladder disease 10.4 SERPINA3 MIR199A1 MIR145 MIR143
24 bile duct adenocarcinoma 10.4 SERPINA3 MIR199A1 MIR145 MIR125A
25 malignant ovarian surface epithelial-stromal neoplasm 10.4 SERPINA3 MIR199A1 MIR145 MIR125A
26 hemopericardium 10.4 PLG ELN
27 ovary epithelial cancer 10.4 SERPINA3 MIR199A1 MIR145 MIR125A
28 vein disease 10.4 SERPINA3 PLG EDN1
29 autoimmune disease of gastrointestinal tract 10.4 SERPINA3 MIRLET7E MIR199A1 MIR125B1
30 laryngeal disease 10.4 MIRLET7E MIR574 MIR143 MIR125A
31 central retinal artery occlusion 10.4 PLG EDN1 ACTA2
32 endocrine organ benign neoplasm 10.4 SERPINA3 MIR199A1 MIR181A1
33 thyroid gland disease 10.3 SERPINA3 MIR199A1 MIR181A1 MIR125A
34 nasopharyngeal disease 10.3 MIR574 MIR199A1 MIR143 MIR125A
35 spinal disease 10.3 SERPINA3 MIR199A1 MIR125B1 MIR125A
36 bone marrow cancer 10.3 SERPINA3 MIR199A1 MIR145 MIR125A
37 senile ectropion 10.3 MMP9 ELN
38 autonomic nervous system neoplasm 10.3 SERPINA3 MIR199A1 MIR181A1 MIR125A
39 oral cavity cancer 10.3 MIR199A1 MIR181A1 MIR145 MIR143
40 malignant astrocytoma 10.3 SERPINA3 MIR199A1 MIR125B1 MIR125A
41 peripheral nervous system neoplasm 10.3 SERPINA3 MIR199A1 MIR181A1 MIR125A
42 mouth disease 10.3 SERPINA3 MIR181A1 MIR145 MIR125A
43 overnutrition 10.3 SERPINA3 MIR199A1 MIR181A1 MIR125A
44 odontogenic myxoma 10.3 SERPINA3 MMP9
45 mitral valve disease 10.3 SERPINA3 NOS3 ELN
46 sensory system disease 10.3 SERPINA3 MIR199A1 MIR181A1 MIR125A
47 ocular cancer 10.3 PLG MIR199A1 MIR143 MIR125A
48 pancreatitis, hereditary 10.3 MIR199A1 MIR125B1 MIR125A
49 pulmonary emphysema 10.3 SERPINA3 MMP9 ELN
50 heart valve disease 10.3 SERPINA3 MIR199A1 ELN

Graphical network of the top 20 diseases related to Cerebral Arterial Disease:



Diseases related to Cerebral Arterial Disease

Symptoms & Phenotypes for Cerebral Arterial Disease

Drugs & Therapeutics for Cerebral Arterial Disease

Drugs for Cerebral Arterial Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 40)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Esmolol Approved Phase 3 81147-92-4, 103598-03-4 59768
2
Propofol Approved, Investigational, Vet_approved Phase 3 2078-54-8 4943
3
Sevoflurane Approved, Vet_approved Phase 3 28523-86-6 5206
4 Chelating Agents Phase 3
5 Gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate Phase 3
6 Anesthetics Phase 3
7 Hypnotics and Sedatives Phase 3
8 Anesthetics, General Phase 3
9 Adrenergic Antagonists Phase 3
10 Anesthetics, Inhalation Phase 3
11 Adrenergic beta-Antagonists Phase 3
12 Anesthetics, Intravenous Phase 3
13 Platelet Aggregation Inhibitors Phase 3
14 Adrenergic beta-1 Receptor Antagonists Phase 3
15 Adrenergic Agents Phase 3
16 Neurotransmitter Agents Phase 3
17
Clopidogrel Approved 120202-66-6, 113665-84-2 60606
18
Polyestradiol phosphate Approved Early Phase 1 28014-46-2
19
Estradiol Approved, Investigational, Vet_approved Early Phase 1 50-28-2 5757
20
Ketorolac Approved Early Phase 1 74103-06-3, 66635-83-4 3826
21
Ganirelix Approved Early Phase 1 124904-93-4, 123246-29-7 25081094
22
Testosterone Approved, Investigational Early Phase 1 58-22-0 6013
23
Nitric Oxide Approved Early Phase 1 10102-43-9 145068
24 Fibrinolytic Agents
25 Purinergic P2Y Receptor Antagonists
26 Antirheumatic Agents Early Phase 1
27 Hormones Early Phase 1
28 omega-N-Methylarginine Early Phase 1
29 Hormone Antagonists Early Phase 1
30 Estradiol 3-benzoate Early Phase 1
31 Estradiol 17 beta-cypionate Early Phase 1
32 Anti-Inflammatory Agents Early Phase 1
33 Cyclooxygenase Inhibitors Early Phase 1
34 Estrogens Early Phase 1
35 Analgesics, Non-Narcotic Early Phase 1
36 Androgens Early Phase 1
37 Ketorolac Tromethamine Early Phase 1
38 Anti-Inflammatory Agents, Non-Steroidal Early Phase 1
39 Analgesics Early Phase 1
40 Acidophilus

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Evaluation of Dotarem-enhanced MRA Compared to Time-Of-Flight (TOF) MRA in the Diagnosis of Carotid and Vertebral Basilar Arterial Disease Completed NCT01012674 Phase 3 Dotarem
2 Evaluation of Dotarem-enhanced MRA Compared to Time-Of-Flight (TOF) MRA in the Diagnosis of Carotid and Vertebral Basilar Arterial Disease Completed NCT01010932 Phase 3 Dotarem
3 Esmolol Reduces Anesthetic Requirements Thereby Facilitating Early Extubation; a Prospective Controlled Study in Patients Undergoing Intracranial Surgery Completed NCT02455440 Phase 3 Esmolol;Placebo;Propofol and sevoflurane
4 Modulation of Brain Blood Flow Using Dichoptic Visual and Auditory Stimulation Unknown status NCT03632564
5 Prospective Observation for Serial Changes of Acute Intracranial Artery Dissection Using High Resolution MRI Unknown status NCT02914288
6 Prescription and Persistence of Antithrombotic Agents in Acute Ischemic Stroke or Transient Ischemic Attack Patients With MCA(Middle Cerebral Artery) Disease Unknown status NCT02953405 Clopidogrel
7 Normal Values of Cerebral Oxygenation Completed NCT00512447
8 Human Cerebral Blood Flow Regulation: Sex, Mechanism, and Stress Differences Recruiting NCT04265053 Early Phase 1 L-NMMA;Ketorolac Tromethamine;Ganirelix Acetate;Testosterone Transdermal Product;Estradiol Topical
9 Acute Impact of Probiotic Supplementation on Endothelial Function in Adults Recruiting NCT04364074

Search NIH Clinical Center for Cerebral Arterial Disease

Cochrane evidence based reviews: cerebral arterial diseases

Genetic Tests for Cerebral Arterial Disease

Anatomical Context for Cerebral Arterial Disease

MalaCards organs/tissues related to Cerebral Arterial Disease:

40
Heart, Kidney, Bone, Lung, Breast, Prostate, Cervix

Publications for Cerebral Arterial Disease

Articles related to Cerebral Arterial Disease:

(show all 49)
# Title Authors PMID Year
1
Pathogenesis and Management in Cerebrovenous Outflow Disorders. 61
33532137 2021
2
Cerebral Small Vessel, But Not Large Vessel Disease, Is Associated With Impaired Cerebral Autoregulation During Cardiopulmonary Bypass: A Retrospective Cohort Study. 61
29677060 2018
3
Spectrum of cerebral arterial and venous abnormalities in Alagille syndrome. 61
29362841 2018
4
Effect of over-2-year dual antiplatelet therapy on the rate of major adverse cardiac and cerebral events for everolimus-eluting stent implantation: The landmark analysis from Tokyo-MD PCI registry. 61
27692568 2017
5
Frequency and Risk Factors for Cerebral Arterial Disease in a HIV/AIDS Neuroimaging Cohort. 61
26751784 2016
6
Intracranial arterial disease in CADASIL patients. 61
26671140 2015
7
Role of BK(Ca) channels in diabetic vascular complications. 61
24791890 2014
8
Improvements in the quantitative assessment of cerebral blood volume and flow with the removal of vessel voxels from MR perfusion images. 61
23586033 2013
9
Associations of ankle-brachial index (ABI) with cerebral arterial disease and vascular events following ischemic stroke. 61
22652527 2012
10
Assessment of pial branches using 7-tesla MRI in cerebral arterial disease. 61
20185908 2010
11
Receptor for advanced glycation end-products (RAGE) and soluble RAGE (sRAGE): cardiovascular implications. 61
19156622 2009
12
A rational connection of inflammation with peripheral arterial disease. 61
17555883 2007
13
Preoperative transcranial and carotid Doppler study in coronary artery bypass graft patients. 61
21857617 2007
14
Targeting cerebral arteries for gene therapy. 61
15778412 2005
15
Position Paper on urine alkalinization. 61
15083932 2004
16
Pharmacologic therapy for peripheral arterial disease and claudication. 61
12469066 2002
17
Isolated petrous carotid stenosis and transient ischemic attack. 61
11296591 2001
18
Coronary artery bypass grafting using the "Super Pulse" dynamic pulsatile cardiopulmonary bypass device in patients with cerebrovascular occlusive disease. 61
10899686 2000
19
[Speech activation SPECT measurements in the determination of hemispheric dominance]. 61
10647268 1999
20
Risk factors for stroke in different levels of cerebral arterial disease. 61
10529541 1999
21
Thrombotic events during oral anticoagulant treatment: results of the inception-cohort, prospective, collaborative ISCOAT study: ISCOAT study group (Italian Study on Complications of Oral Anticoagulant Therapy). 61
9423791 1997
22
Isolated cerebral thrombo-embolism and Crohn disease. 61
8529679 1995
23
Deleterious effects of salt intake other than effects on blood pressure. 61
7554410 1995
24
High prevalence of unsuspected abdominal aortic aneurysm in patients with confirmed symptomatic peripheral or cerebral arterial disease. 61
8518892 1993
25
Diabetic nephropathy in insulin-dependent patients. 61
1462980 1992
26
[20 years pentoxifylline: a part of recent angiology history]. 61
1475991 1992
27
Large-vessel occlusion in sickle cell disease: pathogenesis, clinical consequences, and therapeutic implications. 61
1890982 1991
28
[Cerebral infarction after coronary artery bypass surgery--its cause, management and prevention]. 61
1875899 1991
29
Basis for an international classification of cerebral arterial diseases. 61
3488419 1986
30
Papaverine-induced chronic liver disease. 61
3949106 1986
31
Brain revascularisation in hypertension. 61
4091584 1985
32
A case of internal carotid artery occlusion successfully treated by encephalo-duro-arterio-synangiosis. 61
3833339 1985
33
[Hemofiltration in peripheral and cerebral arterial diseases]. 61
6521947 1984
34
Measurement of carotid blood flow in man and its clinical application. 61
6220490 1983
35
Occlusive cerebral arterial disease. 61
6839323 1983
36
Epileptic seizures in cerebral arterial occlusive disease. 61
7064190 1982
37
A host of hypercholesterolaemic homozygotes in South Africa. 61
7437743 1980
38
Fibromuscular dysplasia in a child: a generalized arterial disease. 61
7446106 1980
39
[Quantitative analysis of lipoproteins in hyperlipoproteinemias of type IIa, IIb and IV (author's transl)]. 61
227624 1979
40
Circannual rhythm of arterial and venous thromboembolic disease. 61
555814 1979
41
Intracranial bypass surgery for cerebral arterial disease and the responsibility of the practicing physician. 61
462524 1979
42
Effect of ethyl apovincaminate on the cerebral circulation. Studies in patients with obliterative cerebral arterial disease. 61
1037221 1976
43
Measures of clinical efficacy. The value of case finding in hypertensive renovascular disease. 61
1143301 1975
44
Cerebral arterial disease in children. An angiographic study of 40 cases. 61
5579392 1971
45
[Cerebral arterial diseases]. 61
5390410 1969
46
The significance of naturally occurring coronary and cerebral arterial disease in animals. 61
5253796 1968
47
Cerebral strokes associated with pregnancy and the puerperium. 61
5662974 1968
48
Cerebral arterial disease. 61
14430850 1959
49
Cerebral arterial disease. 61
14417991 1959

Variations for Cerebral Arterial Disease

Expression for Cerebral Arterial Disease

Search GEO for disease gene expression data for Cerebral Arterial Disease.

Pathways for Cerebral Arterial Disease

Pathways related to Cerebral Arterial Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.72 MMP9 MIRLET7E MIR199A1 MIR181A1 MIR145 MIR143
2 11.13 MMP9 ELN EDN1
3 10.72 PLG MMP9 ELN
4 10.37 MIR199A1 MIR145

GO Terms for Cerebral Arterial Disease

Cellular components related to Cerebral Arterial Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 extracellular exosome GO:0070062 9.85 SERPINA3 PLG PKD2 PKD1 MMP9 MIR145
2 extracellular space GO:0005615 9.4 SERPINA3 PLG MMP9 MIRLET7E MIR574 MIR199A1
3 cation channel complex GO:0034703 9.26 PKD2 PKD1
4 polycystin complex GO:0002133 8.96 PKD2 PKD1

Biological processes related to Cerebral Arterial Disease according to GeneCards Suite gene sharing:

(show all 29)
# Name GO ID Score Top Affiliating Genes
1 positive regulation of gene expression GO:0010628 10.01 PKD2 NOS3 MIR125A CDKN2B-AS1 ACTA2
2 positive regulation of cell migration GO:0030335 9.92 MMP9 MIR181A1 EDN1 CDKN2B-AS1
3 positive regulation of cytosolic calcium ion concentration GO:0007204 9.83 PKD2 PKD1 MIR199A1 EDN1
4 negative regulation of interleukin-6 production GO:0032715 9.78 MIRLET7E MIR181A1 MIR125A
5 regulation of blood pressure GO:0008217 9.75 NOS3 EDN1 ACTA2
6 negative regulation of angiogenesis GO:0016525 9.73 MIR145 MIR143 MIR125B1 MIR125A
7 miRNA mediated inhibition of translation GO:0035278 9.71 MIRLET7E MIR181A1 MIR145 MIR125B1
8 positive regulation of nitric oxide biosynthetic process GO:0045429 9.69 PKD2 MIR181A1 EDN1
9 negative regulation of tyrosine phosphorylation of STAT protein GO:0042532 9.64 MIRLET7E MIR125A
10 positive regulation of cell growth involved in cardiac muscle cell development GO:0061051 9.64 MIR199A1 EDN1
11 protein heterotetramerization GO:0051290 9.63 PKD2 PKD1
12 placenta blood vessel development GO:0060674 9.63 PKD2 PKD1
13 detection of mechanical stimulus GO:0050982 9.62 PKD2 PKD1
14 negative regulation of leukocyte adhesion to vascular endothelial cell GO:1904995 9.6 MIRLET7E MIR125A
15 cytoplasmic sequestering of transcription factor GO:0042994 9.59 PKD2 PKD1
16 angiotensin-activated signaling pathway GO:0038166 9.58 MIR145 MIR143
17 response to fluid shear stress GO:0034405 9.57 PKD1 NOS3
18 regulation of systemic arterial blood pressure by endothelin GO:0003100 9.56 NOS3 EDN1
19 mesonephric tubule development GO:0072164 9.55 PKD2 PKD1
20 aorta smooth muscle tissue morphogenesis GO:0060414 9.54 MIR145 MIR143
21 regulation of phenotypic switching GO:1900239 9.49 MIR145 MIR143
22 metanephric ascending thin limb development GO:0072218 9.48 PKD2 PKD1
23 mesonephric duct development GO:0072177 9.46 PKD2 PKD1
24 cell-cell signaling by wnt GO:0198738 9.37 PKD2 PKD1
25 negative regulation of interleukin-6-mediated signaling pathway GO:0070104 9.33 MIRLET7E MIR125B1 MIR125A
26 establishment or maintenance of cell type involved in phenotypic switching GO:0044663 9.32 MIR145 MIR143
27 negative regulation of interleukin-16 production GO:0032699 9.26 MIR145 MIR125A
28 gene silencing by miRNA GO:0035195 9.23 MIRLET7E MIR574 MIR199A1 MIR181A1 MIR145 MIR143
29 negative regulation of STAT cascade GO:1904893 9.13 MIRLET7E MIR125B1 MIR125A

Molecular functions related to Cerebral Arterial Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.26 MIR181A1 MIR145 MIR143 MIR125A
2 mRNA binding involved in posttranscriptional gene silencing GO:1903231 9.17 MIRLET7E MIR199A1 MIR181A1 MIR145 MIR143 MIR125B1

Sources for Cerebral Arterial Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
20 GARD
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
53 NINDS
54 Novoseek
56 OMIM via Orphanet
57 OMIM® (Updated 20-May-2021)
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 Tocris
70 UMLS
71 UMLS via Orphanet
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