Cerebral Arterial Disease disease: Malacards - Research Articles, Drugs, Genes, Clinical Trials

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Aliases & Classifications for Cerebral Arterial Disease

MalaCards integrated aliases for Cerebral Arterial Disease:

Name: Cerebral Arterial Disease ¹¹ ¹⁴ ¹⁶

Cerebral Arterial Diseases ⁴³ ⁷¹

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Neuronal diseases

See all MalaCards categories (disease lists)

External Ids:

Disease Ontology ¹¹ DOID:3527

MeSH ⁴³ D002539

EFO ¹⁶ EFO_1000859

UMLS ⁷¹ C0007774

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Summaries for Cerebral Arterial Disease

MalaCards based summary: Cerebral Arterial Disease, also known as cerebral arterial diseases, is related to moyamoya disease 1 and peripheral vascular disease. An important gene associated with Cerebral Arterial Disease is RNF213 (Ring Finger Protein 213), and among its related pathways/superpathways are Lung fibrosis and miRNAs involvement in the immune response in sepsis. The drugs Esmolol and Sevoflurane have been mentioned in the context of this disorder. Affiliated tissues include endothelial, brain and liver, and related phenotype is cardiovascular system.

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Related Diseases for Cerebral Arterial Disease

Diseases related to Cerebral Arterial Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 187)

#	Related Disease	Score	Top Affiliating Genes
1	moyamoya disease 1	31.7	THSD1 SERPINA3 RNF213 PLG MMP9 MIR126
2	peripheral vascular disease	30.2	SERPINA3 PLG MIR126 EDN1
3	aortic aneurysm	30.0	MMP9 MIR145 MIR126 ELN CDKN2B-AS1 ACTA2
4	stroke, ischemic	30.0	SERPINA3 PLG MMP9 MIR4793 MIR126 CDKN2B-AS1
5	cerebrovascular disease	30.0	SERPINA3 PLG MIR145 MIR144 MIR143 MIR126
6	vascular disease	30.0	MMP9 MIR145 MIR143 MIR126 MIR125A ELN
7	aortic aneurysm, familial abdominal, 1	29.8	SERPINA3 PLG MMP9 MIR144 MIR126 ELN
8	cerebral atherosclerosis	10.4	SERPINA3 RNF213 MIR126
9	congenital hepatic fibrosis	10.4	PKD2 PKD1
10	cerebral aneurysms	10.4	PKD1 ELN
11	ovarian serous carcinoma	10.4	MIR145 MIR143 MIR125A
12	pleuropulmonary blastoma	10.4	MIR126 MIR125B1 MIR125A
13	cervix small cell carcinoma	10.4	MIR145 MIR143
14	bone deterioration disease	10.4	MIR143 MIR126 MIR125B1
15	pulmonary artery disease	10.4	SERPINA3 PLG MIR126
16	mitral valve stenosis	10.4	SERPINA3 PLG EDN1
17	retinal vascular occlusion	10.4	SERPINA3 PLG EDN1
18	colorectal adenocarcinoma	10.4	MIR145 MIR143 MIR126
19	retinal artery occlusion	10.4	SERPINA3 PLG ACTA2
20	bone sarcoma	10.3	SERPINA3 MIR143 MIR126 MIR125A
21	leukocyte disease	10.3	SERPINA3 MIR145 MIR126 MIR125A
22	intermediate coronary syndrome	10.3	MIR145 MIR126 EDN1
23	malignant ovarian surface epithelial-stromal neoplasm	10.3	SERPINA3 MIR145 MIR126 MIR125A
24	multicystic dysplastic kidney	10.3	PKD2 PKD1
25	cerebral artery occlusion	10.3	PLG MMP9 EDN1
26	nonobstructive coronary artery disease	10.3	SERPINA3 MIR126 EDN1 CDKN2B-AS1
27	mitral valve disease	10.3	SERPINA3 ELN EDN1
28	integumentary system disease	10.3	SERPINA3 MIR145 MIR126 MIR125A
29	pancreatitis, hereditary	10.3	MIR126 MIR125B1 MIR125A
30	endocrine organ benign neoplasm	10.3	SERPINA3 MIR145 MIR144 MIR126
31	colonic benign neoplasm	10.3	SERPINA3 MMP9 MIR145 MIR143
32	spinal cord disease	10.3	SERPINA3 MIR126 MIR125A
33	carotid artery disease	10.3	PLG MMP9 MIR126
34	heart conduction disease	10.3	SERPINA3 PLG MIR145 MIR126
35	collagen disease	10.3	SERPINA3 ELN ACTA2
36	autoimmune disease of gastrointestinal tract	10.3	SERPINA3 MIR126 MIR125B1
37	polycystic kidney disease 3 with or without polycystic liver disease	10.3	PKD2 PKD1
38	primary bacterial infectious disease	10.3	SERPINA3 MIR144 MIR126 MIR125A
39	retinal vascular disease	10.3	SERPINA3 PLG MIR126
40	oligohydramnios	10.3	PKD1 MIR574 EDN1
41	autoimmune disease of central nervous system	10.3	SERPINA3 MIR144 MIR126 MIR125A
42	ovary epithelial cancer	10.3	SERPINA3 MIR145 MIR143 MIR126 MIR125A
43	bone inflammation disease	10.3	SERPINA3 MMP9 MIR126 MIR125A
44	large cell carcinoma	10.3	MIR145 MIR144 MIR126
45	heart valve disease	10.3	SERPINA3 MIR126 ELN EDN1
46	pulmonary emphysema	10.3	SERPINA3 MMP9 ELN
47	demyelinating disease	10.3	SERPINA3 MMP9 MIR126 MIR125A
48	bone marrow cancer	10.3	MIR145 MIR144 MIR126 MIR125A
49	gastrointestinal system benign neoplasm	10.3	SERPINA3 MIR144 MIR143
50	vein disease	10.3	SERPINA3 PLG MMP9 EDN1

Graphical network of the top 20 diseases related to Cerebral Arterial Disease:

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Symptoms & Phenotypes for Cerebral Arterial Disease

MGI Mouse Phenotypes related to Cerebral Arterial Disease:

⁴⁵

#	Description	MGI Source Accession	Score	Top Affiliating Genes
1	cardiovascular system	MP:0005385	9.36	ACTA2 EDN1 ELN MIR126 MIR143 MIR145

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Drugs & Therapeutics for Cerebral Arterial Disease

Drugs for Cerebral Arterial Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)

#

Name

Status

Phase

Clinical Trials

Cas Number

PubChem Id

1

Esmolol

Approved, Withdrawn

Phase 3

103598-03-4, 81147-92-4

59768

2

Sevoflurane

Approved, Vet_approved

Phase 3

28523-86-6

5206

3

Propofol

Approved, Investigational, Vet_approved

Phase 3

2078-54-8

4943

4

Neurotransmitter Agents

Phase 3

5

Adrenergic beta-Antagonists

Phase 3

6

Adrenergic beta-1 Receptor Antagonists

Phase 3

7

Adrenergic Antagonists

Phase 3

8

Adrenergic Agents

Phase 3

9

Platelet Aggregation Inhibitors

Phase 3

10

Anesthetics, Intravenous

Phase 3

11

Anesthetics, Inhalation

Phase 3

12

Anesthetics, General

Phase 3

13

Anesthetics

Phase 3

14

Hypnotics and Sedatives

Phase 3

15

Gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate

Phase 3

16

Chelating Agents

Phase 3

17

Estradiol

Approved, Investigational, Vet_approved

Early Phase 1

50-28-2

5757

18

Ketorolac

Approved

Early Phase 1

74103-06-3, 66635-83-4

3826

19

Nitric Oxide

Approved

Early Phase 1

10102-43-9

145068

20

Polyestradiol phosphate

Approved

Early Phase 1

28014-46-2

21

Ganirelix

Approved

Early Phase 1

124904-93-4

44208957 16186319 16130966

22

Testosterone

Approved, Investigational

Early Phase 1

58-22-0

5408 6013

23

Antirheumatic Agents

Early Phase 1

24

Estrogens

Early Phase 1

25

Estradiol 3-benzoate

Early Phase 1

26

Estradiol 17 beta-cypionate

Early Phase 1

27

Ketorolac Tromethamine

Early Phase 1

28

Hormones

Early Phase 1

29

Cyclooxygenase Inhibitors

Early Phase 1

30

Hormone Antagonists

Early Phase 1

31

Anti-Inflammatory Agents, Non-Steroidal

Early Phase 1

32

omega-N-Methylarginine

Early Phase 1

33

Androgens

Early Phase 1

34

Analgesics, Non-Narcotic

Early Phase 1

35

Anti-Inflammatory Agents

Early Phase 1

36

Analgesics

Early Phase 1

37

Acidophilus

Interventional clinical trials:

#	Name	Status	NCT ID	Phase	Drugs
1	Esmolol Reduces Anesthetic Requirements Thereby Facilitating Early Extubation; a Prospective Controlled Study in Patients Undergoing Intracranial Surgery	Completed	NCT02455440	Phase 3	Esmolol;Placebo;Propofol and sevoflurane
2	Evaluation of Dotarem-enhanced MRA Compared to Time-Of-Flight (TOF) MRA in the Diagnosis of Carotid and Vertebral Basilar Arterial Disease	Completed	NCT01012674	Phase 3	Dotarem
3	Evaluation of Dotarem-enhanced MRA Compared to Time-Of-Flight (TOF) MRA in the Diagnosis of Carotid and Vertebral Basilar Arterial Disease	Completed	NCT01010932	Phase 3	Dotarem
4	Modulation of Brain Blood Flow Using Dichoptic Visual and Auditory Stimulation	Unknown status	NCT03632564
5	Prospective Observation for Serial Changes of Acute Intracranial Artery Dissection Using High Resolution MRI	Unknown status	NCT02914288
6	Normal Values of Cerebral Oxygenation	Completed	NCT00512447
7	Human Cerebral Blood Flow Regulation: Sex, Mechanism, and Stress Differences	Recruiting	NCT04265053	Early Phase 1	L-NMMA;Ketorolac Tromethamine;Ganirelix Acetate;Testosterone Transdermal Product;Estradiol Topical
8	Acute Impact of Probiotic Supplementation on Endothelial Function in Adults	Active, not recruiting	NCT04364074

Search NIH Clinical Center for Cerebral Arterial Disease

Cochrane evidence based reviews: cerebral arterial diseases

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Genetic Tests for Cerebral Arterial Disease

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Anatomical Context for Cerebral Arterial Disease

Organs/tissues related to Cerebral Arterial Disease:

MalaCards : Endothelial, Brain, Liver

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Publications for Cerebral Arterial Disease

Articles related to Cerebral Arterial Disease:

(show all 45)

#	Title	Authors	PMID	Year
1	Pathogenesis and Management in Cerebrovenous Outflow Disorders. ⁶²	Bai C...Meng R	33532137	2021
2	Cerebral Small Vessel, But Not Large Vessel Disease, Is Associated With Impaired Cerebral Autoregulation During Cardiopulmonary Bypass: A Retrospective Cohort Study. ⁶²	Nomura Y...Hogue CW	29677060	2018
3	Spectrum of cerebral arterial and venous abnormalities in Alagille syndrome. ⁶²	Carpenter CD...Abruzzo T	29362841	2018
4	Effect of over-2-year dual antiplatelet therapy on the rate of major adverse cardiac and cerebral events for everolimus-eluting stent implantation: The landmark analysis from Tokyo-MD PCI registry. ⁶²	Ueshima D...Isobe M	27692568	2017
5	Frequency and Risk Factors for Cerebral Arterial Disease in a HIV/AIDS Neuroimaging Cohort. ⁶²	Edwards NJ...Ko NU	26751784	2016
6	Intracranial arterial disease in CADASIL patients. ⁶²	Kang HG...Kim JS	26671140	2015
7	Role of BK(Ca) channels in diabetic vascular complications. ⁶²	Qian L...Wang R	24791890	2014
8	Improvements in the quantitative assessment of cerebral blood volume and flow with the removal of vessel voxels from MR perfusion images. ⁶²	Teng MM...Chang FC	23586033	2013
9	Associations of ankle-brachial index (ABI) with cerebral arterial disease and vascular events following ischemic stroke. ⁶²	Manzano JJ...Chen CP	22652527	2012
10	Assessment of pial branches using 7-tesla MRI in cerebral arterial disease. ⁶²	Song HS...Cho ZH	20185908	2010
11	Receptor for advanced glycation end-products (RAGE) and soluble RAGE (sRAGE): cardiovascular implications. ⁶²	Lindsey JB...McGuire DK	19156622	2009
12	Preoperative transcranial and carotid Doppler study in coronary artery bypass graft patients. ⁶²	Farhoudi M...Safaiyan A	21857617	2007
13	A rational connection of inflammation with peripheral arterial disease. ⁶²	Li J...Qian HY	17555883	2007
14	Position Paper on urine alkalinization. ⁶²	Proudfoot AT...Vale JA	15083932	2004
15	Pharmacologic therapy for peripheral arterial disease and claudication. ⁶²	Hiatt WR	12469066	2002
16	Isolated petrous carotid stenosis and transient ischemic attack. ⁶²	Levine RL...Dulli DA	11296591	2001
17	Coronary artery bypass grafting using the "Super Pulse" dynamic pulsatile cardiopulmonary bypass device in patients with cerebrovascular occlusive disease. ⁶²	Higami T...Ogawa K	10899686	2000
18	[Speech activation SPECT measurements in the determination of hemispheric dominance]. ⁶²	Borbely K...Nyary I	10647268	1999
19	Risk factors for stroke in different levels of cerebral arterial disease. ⁶²	Kim JS...Choi-Kwon S	10529541	1999
20	Thrombotic events during oral anticoagulant treatment: results of the inception-cohort, prospective, collaborative ISCOAT study: ISCOAT study group (Italian Study on Complications of Oral Anticoagulant Therapy). ⁶²	Palareti G...Coccheri S	9423791	1997
21	Isolated cerebral thrombo-embolism and Crohn disease. ⁶²	Gormally SM...Drumm B	8529679	1995
22	Deleterious effects of salt intake other than effects on blood pressure. ⁶²	Antonios TF...MacGregor GA	7554410	1995
23	High prevalence of unsuspected abdominal aortic aneurysm in patients with confirmed symptomatic peripheral or cerebral arterial disease. ⁶²	MacSweeney ST...Greenhalgh RM	8518892	1993
24	Diabetic nephropathy in insulin-dependent patients. ⁶²	Breyer JA	1462980	1992
25	[20 years pentoxifylline: a part of recent angiology history]. ⁶²	Ernst E	1475991	1992
26	Large-vessel occlusion in sickle cell disease: pathogenesis, clinical consequences, and therapeutic implications. ⁶²	Francis RB	1890982	1991
27	[Cerebral infarction after coronary artery bypass surgery--its cause, management and prevention]. ⁶²	Makuuchi H...Konishi T	1875899	1991
28	Papaverine-induced chronic liver disease. ⁶²	Poncin E...Beauchant M	3949106	1986
29	Brain revascularisation in hypertension. ⁶²	Willems CE...Dillon MJ	4091584	1985
30	A case of internal carotid artery occlusion successfully treated by encephalo-duro-arterio-synangiosis. ⁶²	Matsushima Y...Inaba Y	3833339	1985
31	Measurement of carotid blood flow in man and its clinical application. ⁶²	Uematsu S...Toung TJ	6220490	1983
32	Occlusive cerebral arterial disease. ⁶²	Wiebers DO	6839323	1983
33	Epileptic seizures in cerebral arterial occlusive disease. ⁶²	Cocito L...Reni L	7064190	1982
34	A host of hypercholesterolaemic homozygotes in South Africa. ⁶²	Seftel HC...Mieny CJ	7437743	1980
35	Fibromuscular dysplasia in a child: a generalized arterial disease. ⁶²	Pesonen E...Jaakelainen J	7446106	1980
36	[Quantitative analysis of lipoproteins in hyperlipoproteinemias of type IIa, IIb and IV (author's transl)]. ⁶²	Loeper J...Rouffy J	227624	1979
37	Circannual rhythm of arterial and venous thromboembolic disease. ⁶²	Entrican JH...Douglas AS	555814	1979
38	Intracranial bypass surgery for cerebral arterial disease and the responsibility of the practicing physician. ⁶²	Reinmuth OM	462524	1979
39	Effect of ethyl apovincaminate on the cerebral circulation. Studies in patients with obliterative cerebral arterial disease. ⁶²	Solti F...Czako E	1037221	1976
40	Measures of clinical efficacy. The value of case finding in hypertensive renovascular disease. ⁶²	McNeil BJ...Adelstein SJ	1143301	1975
41	Cerebral arterial disease in children. An angiographic study of 40 cases. ⁶²	Harwood-Nash DC...Argent W	5579392	1971
42	The significance of naturally occurring coronary and cerebral arterial disease in animals. ⁶²	Detweiler DK...Luginbuhl H	5253796	1968
43	Cerebral strokes associated with pregnancy and the puerperium. ⁶²	Cross JN...Jennett WB	5662974	1968
44	Cerebral arterial disease. ⁶²	PATERSON JH	14430850	1959
45	Cerebral arterial disease. ⁶²	LOGUE V	14417991	1959

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Genes for Cerebral Arterial Disease

Genes related to Cerebral Arterial Disease (0 elite genes):

(show all 40)

- Elite gene

- Cancer Census gene in COSMIC

#	Symbol	Description	Category	Score	Evidence
1	RNF213	Ring Finger Protein 213	Protein Coding	9.22	DISEASES inferred ¹⁴
2	SERPINA3	Serpin Family A Member 3	Protein Coding	8.75	DISEASES inferred ¹⁴ ¹⁴
3	MIR143	MicroRNA 143	RNA Gene	8.74	DISEASES inferred ¹⁴ ¹⁴
4	MIR145	MicroRNA 145	RNA Gene	8.34	DISEASES inferred ¹⁴ ¹⁴
5	MIR126	MicroRNA 126	RNA Gene	8.34	DISEASES inferred ¹⁴ ¹⁴
6	MIR4793	MicroRNA 4793	RNA Gene	7.34	DISEASES inferred ¹⁴ ¹⁴
7	MIR125A	MicroRNA 125a	RNA Gene	7.3	DISEASES inferred ¹⁴ ¹⁴
8	MIR125B1	MicroRNA 125b-1	RNA Gene	7.26	DISEASES inferred ¹⁴ ¹⁴
9	MIR574	MicroRNA 574	RNA Gene	7.09	DISEASES inferred ¹⁴ ¹⁴
10	CDKN2B-AS1	CDKN2B Antisense RNA 1	RNA Gene	7.06	DISEASES inferred ¹⁴
11	PKD1	Polycystin 1, Transient Receptor Potential Channel Interacting	Protein Coding	6.86	DISEASES inferred ¹⁴
12	CDR1-AS	CDR1 Antisense RNA	RNA Gene	6.83	DISEASES inferred ¹⁴ ¹⁴
13	ACTA2	Actin Alpha 2, Smooth Muscle	Protein Coding	6.8	DISEASES inferred ¹⁴
14	PLG	Plasminogen	Protein Coding	6.76	DISEASES inferred ¹⁴
15	PKD2	Polycystin 2, Transient Receptor Potential Cation Channel	Protein Coding	6.65	DISEASES inferred ¹⁴
16	EDN1	Endothelin 1	Protein Coding	6.62	DISEASES inferred ¹⁴
17	MMP9	Matrix Metallopeptidase 9	Protein Coding	6.56	DISEASES inferred ¹⁴
18	ELN	Elastin	Protein Coding	6.55	DISEASES inferred ¹⁴
19	MIR144	MicroRNA 144	RNA Gene	6.52	DISEASES inferred ¹⁴ ¹⁴
20	THSD1	Thrombospondin Type 1 Domain Containing 1	Protein Coding	6.41	DISEASES inferred ¹⁴
21	NF1	Neurofibromin 1	Protein Coding	6.4	DISEASES inferred ¹⁴
22	CDKN2B	Cyclin Dependent Kinase Inhibitor 2B	Protein Coding	6.4	DISEASES inferred ¹⁴
23	NOS3	Nitric Oxide Synthase 3	Protein Coding	6.36	DISEASES inferred ¹⁴
24	MRS2	Magnesium Transporter MRS2	Protein Coding	6.35	DISEASES inferred ¹⁴
25	IL6	Interleukin 6	Protein Coding	6.34	DISEASES inferred ¹⁴
26	EDNRA	Endothelin Receptor Type A	Protein Coding	6.26	DISEASES inferred ¹⁴
27	PLAT	Plasminogen Activator, Tissue Type	Protein Coding	6.23	DISEASES inferred ¹⁴
28	P2RY12	Purinergic Receptor P2Y12	Protein Coding	6.23	DISEASES inferred ¹⁴
29	MIR181A1	MicroRNA 181a-1	RNA Gene	6.23	DISEASES inferred ¹⁴ ¹⁴
30	GUCY1A1	Guanylate Cyclase 1 Soluble Subunit Alpha 1	Protein Coding	6.21	DISEASES inferred ¹⁴
31	CRP	C-Reactive Protein	Protein Coding	6.2	DISEASES inferred ¹⁴
32	S100B	S100 Calcium Binding Protein B	Protein Coding	6.2	DISEASES inferred ¹⁴
33	SOX17	SRY-Box Transcription Factor 17	Protein Coding	6.18	DISEASES inferred ¹⁴
34	IL1B	Interleukin 1 Beta	Protein Coding	6.07	DISEASES inferred ¹⁴
35	MIRLET7E	MicroRNA Let-7e	RNA Gene	6.01	DISEASES inferred ¹⁴ ¹⁴
36	PANX1	Pannexin 1	Protein Coding	6	DISEASES inferred ¹⁴
37	CMC4	C-X9-C Motif Containing 4	Protein Coding	5.98	DISEASES inferred ¹⁴
38	MIR486-1	MicroRNA 486-1	RNA Gene	5.97	DISEASES inferred ¹⁴ ¹⁴
39	COL3A1	Collagen Type III Alpha 1 Chain	Protein Coding	5.96	DISEASES inferred ¹⁴
40	COL4A1	Collagen Type IV Alpha 1 Chain	Protein Coding	5.92	DISEASES inferred ¹⁴

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Variations for Cerebral Arterial Disease

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Expression for Cerebral Arterial Disease

Search GEO for disease gene expression data for Cerebral Arterial Disease.

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Pathways for Cerebral Arterial Disease

Pathways related to Cerebral Arterial Disease according to GeneCards Suite gene sharing:

#	Super pathways	Score	Top Affiliating Genes
1	Lung fibrosis ⁷⁴	11.13	MMP9 ELN EDN1
2	miRNAs involvement in the immune response in sepsis ⁷⁴	10.92	MIR145 MIR126 MIR125B1
3	Cell adhesion_Cell-matrix glycoconjugates ²²	10.39	PLG MMP9 ELN

Sources

GO Terms for Cerebral Arterial Disease

Cellular components related to Cerebral Arterial Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	RISC complex	GO:0016442	9.93	MIR145 MIR144 MIR143 MIR126 MIR125B1 MIR125A
2	extracellular space	GO:0005615	9.86	SERPINA3 PLG MMP9 MIR574 MIR144 MIR143
3	polycystin complex	GO:0002133	8.92	PKD2 PKD1

Biological processes related to Cerebral Arterial Disease according to GeneCards Suite gene sharing:

(show all 16)

#	Name	GO ID	Score	Top Affiliating Genes
1	miRNA-mediated gene silencing	GO:0035195	10.18	MIR574 MIR145 MIR144 MIR143 MIR126 MIR125B1
2	negative regulation of gene expression	GO:0010629	10.01	MIR144 MIR125B1 MIR125A EDN1 CDKN2B-AS1
3	cytoplasmic sequestering of transcription factor	GO:0042994	9.86	PKD2 PKD1
4	mesonephric duct development	GO:0072177	9.81	PKD2 PKD1
5	mesonephric tubule development	GO:0072164	9.76	PKD2 PKD1
6	metanephric ascending thin limb development	GO:0072218	9.73	PKD2 PKD1
7	negative regulation of angiogenesis	GO:0016525	9.71	MIR125A MIR125B1 MIR143 MIR145
8	cell-cell signaling by wnt	GO:0198738	9.56	PKD2 PKD1
9	angiotensin-activated signaling pathway	GO:0038166	9.55	MIR145 MIR143
10	negative regulation of receptor signaling pathway via STAT	GO:1904893	9.52	MIR125B1 MIR125A
11	negative regulation of interleukin-6-mediated signaling pathway	GO:0070104	9.49	MIR125B1 MIR125A
12	aorta smooth muscle tissue morphogenesis	GO:0060414	9.48	MIR145 MIR143
13	regulation of phenotypic switching	GO:1900239	9.32	MIR145 MIR143
14	establishment or maintenance of cell type involved in phenotypic switching	GO:0044663	9.16	MIR145 MIR143
15	negative regulation of interleukin-16 production	GO:0032699	8.96	MIR145 MIR125A
16	miRNA-mediated gene silencing by inhibition of translation	GO:0035278	8.92	MIR145 MIR144 MIR126 MIR125B1

Molecular functions related to Cerebral Arterial Disease according to GeneCards Suite gene sharing:

#	Name	GO ID	Score	Top Affiliating Genes
1	mRNA 3'-UTR binding	GO:0003730	9.43	MIR145 MIR144 MIR143 MIR126 MIR125B1 MIR125A
2	mRNA base-pairing translational repressor activity	GO:1903231	9.1	MIR145 MIR144 MIR143 MIR126 MIR125B1 MIR125A

Sources

Sources for Cerebral Arterial Disease

¹ BitterDB

² CDC

³ Cell Signaling Technology

⁴ ClinicalTrials

⁵ ClinVar

⁶ CNVD

⁷ Cochrane Library

⁸ Cosmic

⁹ dbSNP

¹⁰ DGIdb

¹¹ Disease Ontology

¹² diseasecard

¹³ DiseaseEnhancer

¹⁴ DISEASES

¹⁵ DrugBank

¹⁶ EFO

¹⁷ ExPASy

¹⁸ FMA

¹⁹ GARD

²⁰ GeneAnalytics

²¹ GeneCards

²² GeneGo (Thomson Reuters)

²³ GeneHancer via GeneCards

²⁴ GeneReviews

²⁵ GenomeRNAi

²⁶ GEO DataSets

²⁷ GO

²⁸ GTR

²⁹ HMDB

³⁰ HPO

³¹ ICD10

³² ICD10 via Orphanet

³³ ICD11

³⁴ ICD9CM

³⁵ IUPHAR

³⁶ LifeMap

³⁷ LncRNADisease

³⁸ LOVD

³⁹ MalaCards

⁴⁰ MedGen

⁴¹ MedlinePlus

⁴² MedlinePlus Genetics

⁴³ MeSH

⁴⁴ MESH via Orphanet

⁴⁵ MGI

⁴⁶ miR2Disease

⁴⁷ NCBI Bookshelf

⁴⁸ NCI

⁴⁹ NCIt

⁵⁰ NDF-RT

⁵¹ NIH Clinical Center

⁵² NINDS

⁵³ Novoseek

⁵⁴ Novus Biologicals

⁵⁵ ODiseA

⁵⁶ OMIM via Orphanet

⁵⁷ OMIM® (Updated 08-Dec-2022)

⁵⁸ Orphanet

⁵⁹ PathCards

⁶⁰ PharmGKB

⁶¹ PubChem

⁶² PubMed

⁶³ PubMed Health

⁶⁴ QIAGEN

⁶⁵ R&D Systems

⁶⁶ Reactome

⁶⁷ Sino Biological

⁶⁸ SNOMED-CT

⁶⁹ SNOMED-CT via HPO

⁷⁰ Tocris

⁷¹ UMLS

⁷² UMLS via Orphanet

⁷³ UniProtKB/Swiss-Prot

⁷⁴ WikiPathways

⁷⁵ Wikipedia

MCID: CRB031 MIFTS: 33	Cerebral Arterial Disease Categories: Cardiovascular diseases, Neuronal diseases	Data Licensing For inquiries, contact: [email protected]
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