MCID: CRB031
MIFTS: 33

Cerebral Arterial Disease

Categories: Cardiovascular diseases, Neuronal diseases
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Aliases & Classifications for Cerebral Arterial Disease

MalaCards integrated aliases for Cerebral Arterial Disease:

Name: Cerebral Arterial Disease 11 14 16
Cerebral Arterial Diseases 43 71

Classifications:



External Ids:

Disease Ontology 11 DOID:3527
MeSH 43 D002539
UMLS 71 C0007774

Summaries for Cerebral Arterial Disease

MalaCards based summary: Cerebral Arterial Disease, also known as cerebral arterial diseases, is related to moyamoya disease 1 and peripheral vascular disease. An important gene associated with Cerebral Arterial Disease is RNF213 (Ring Finger Protein 213), and among its related pathways/superpathways are Lung fibrosis and miRNAs involvement in the immune response in sepsis. The drugs Esmolol and Sevoflurane have been mentioned in the context of this disorder. Affiliated tissues include endothelial, brain and liver, and related phenotype is cardiovascular system.

Related Diseases for Cerebral Arterial Disease

Diseases related to Cerebral Arterial Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show top 50) (show all 187)
# Related Disease Score Top Affiliating Genes
1 moyamoya disease 1 31.7 THSD1 SERPINA3 RNF213 PLG MMP9 MIR126
2 peripheral vascular disease 30.2 SERPINA3 PLG MIR126 EDN1
3 aortic aneurysm 30.0 MMP9 MIR145 MIR126 ELN CDKN2B-AS1 ACTA2
4 stroke, ischemic 30.0 SERPINA3 PLG MMP9 MIR4793 MIR126 CDKN2B-AS1
5 cerebrovascular disease 30.0 SERPINA3 PLG MIR145 MIR144 MIR143 MIR126
6 vascular disease 30.0 MMP9 MIR145 MIR143 MIR126 MIR125A ELN
7 aortic aneurysm, familial abdominal, 1 29.8 SERPINA3 PLG MMP9 MIR144 MIR126 ELN
8 cerebral atherosclerosis 10.4 SERPINA3 RNF213 MIR126
9 congenital hepatic fibrosis 10.4 PKD2 PKD1
10 cerebral aneurysms 10.4 PKD1 ELN
11 ovarian serous carcinoma 10.4 MIR145 MIR143 MIR125A
12 pleuropulmonary blastoma 10.4 MIR126 MIR125B1 MIR125A
13 cervix small cell carcinoma 10.4 MIR145 MIR143
14 bone deterioration disease 10.4 MIR143 MIR126 MIR125B1
15 pulmonary artery disease 10.4 SERPINA3 PLG MIR126
16 mitral valve stenosis 10.4 SERPINA3 PLG EDN1
17 retinal vascular occlusion 10.4 SERPINA3 PLG EDN1
18 colorectal adenocarcinoma 10.4 MIR145 MIR143 MIR126
19 retinal artery occlusion 10.4 SERPINA3 PLG ACTA2
20 bone sarcoma 10.3 SERPINA3 MIR143 MIR126 MIR125A
21 leukocyte disease 10.3 SERPINA3 MIR145 MIR126 MIR125A
22 intermediate coronary syndrome 10.3 MIR145 MIR126 EDN1
23 malignant ovarian surface epithelial-stromal neoplasm 10.3 SERPINA3 MIR145 MIR126 MIR125A
24 multicystic dysplastic kidney 10.3 PKD2 PKD1
25 cerebral artery occlusion 10.3 PLG MMP9 EDN1
26 nonobstructive coronary artery disease 10.3 SERPINA3 MIR126 EDN1 CDKN2B-AS1
27 mitral valve disease 10.3 SERPINA3 ELN EDN1
28 integumentary system disease 10.3 SERPINA3 MIR145 MIR126 MIR125A
29 pancreatitis, hereditary 10.3 MIR126 MIR125B1 MIR125A
30 endocrine organ benign neoplasm 10.3 SERPINA3 MIR145 MIR144 MIR126
31 colonic benign neoplasm 10.3 SERPINA3 MMP9 MIR145 MIR143
32 spinal cord disease 10.3 SERPINA3 MIR126 MIR125A
33 carotid artery disease 10.3 PLG MMP9 MIR126
34 heart conduction disease 10.3 SERPINA3 PLG MIR145 MIR126
35 collagen disease 10.3 SERPINA3 ELN ACTA2
36 autoimmune disease of gastrointestinal tract 10.3 SERPINA3 MIR126 MIR125B1
37 polycystic kidney disease 3 with or without polycystic liver disease 10.3 PKD2 PKD1
38 primary bacterial infectious disease 10.3 SERPINA3 MIR144 MIR126 MIR125A
39 retinal vascular disease 10.3 SERPINA3 PLG MIR126
40 oligohydramnios 10.3 PKD1 MIR574 EDN1
41 autoimmune disease of central nervous system 10.3 SERPINA3 MIR144 MIR126 MIR125A
42 ovary epithelial cancer 10.3 SERPINA3 MIR145 MIR143 MIR126 MIR125A
43 bone inflammation disease 10.3 SERPINA3 MMP9 MIR126 MIR125A
44 large cell carcinoma 10.3 MIR145 MIR144 MIR126
45 heart valve disease 10.3 SERPINA3 MIR126 ELN EDN1
46 pulmonary emphysema 10.3 SERPINA3 MMP9 ELN
47 demyelinating disease 10.3 SERPINA3 MMP9 MIR126 MIR125A
48 bone marrow cancer 10.3 MIR145 MIR144 MIR126 MIR125A
49 gastrointestinal system benign neoplasm 10.3 SERPINA3 MIR144 MIR143
50 vein disease 10.3 SERPINA3 PLG MMP9 EDN1

Graphical network of the top 20 diseases related to Cerebral Arterial Disease:



Diseases related to Cerebral Arterial Disease

Symptoms & Phenotypes for Cerebral Arterial Disease

MGI Mouse Phenotypes related to Cerebral Arterial Disease:

45
# Description MGI Source Accession Score Top Affiliating Genes
1 cardiovascular system MP:0005385 9.36 ACTA2 EDN1 ELN MIR126 MIR143 MIR145

Drugs & Therapeutics for Cerebral Arterial Disease

Drugs for Cerebral Arterial Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 37)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Esmolol Approved, Withdrawn Phase 3 103598-03-4, 81147-92-4 59768
2
Sevoflurane Approved, Vet_approved Phase 3 28523-86-6 5206
3
Propofol Approved, Investigational, Vet_approved Phase 3 2078-54-8 4943
4 Neurotransmitter Agents Phase 3
5 Adrenergic beta-Antagonists Phase 3
6 Adrenergic beta-1 Receptor Antagonists Phase 3
7 Adrenergic Antagonists Phase 3
8 Adrenergic Agents Phase 3
9 Platelet Aggregation Inhibitors Phase 3
10 Anesthetics, Intravenous Phase 3
11 Anesthetics, Inhalation Phase 3
12 Anesthetics, General Phase 3
13 Anesthetics Phase 3
14 Hypnotics and Sedatives Phase 3
15 Gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate Phase 3
16 Chelating Agents Phase 3
17
Estradiol Approved, Investigational, Vet_approved Early Phase 1 50-28-2 5757
18
Ketorolac Approved Early Phase 1 74103-06-3, 66635-83-4 3826
19
Nitric Oxide Approved Early Phase 1 10102-43-9 145068
20
Polyestradiol phosphate Approved Early Phase 1 28014-46-2
21
Ganirelix Approved Early Phase 1 124904-93-4 44208957 16186319 16130966
22
Testosterone Approved, Investigational Early Phase 1 58-22-0 5408 6013
23 Antirheumatic Agents Early Phase 1
24 Estrogens Early Phase 1
25 Estradiol 3-benzoate Early Phase 1
26 Estradiol 17 beta-cypionate Early Phase 1
27
Ketorolac Tromethamine Early Phase 1
28 Hormones Early Phase 1
29 Cyclooxygenase Inhibitors Early Phase 1
30 Hormone Antagonists Early Phase 1
31 Anti-Inflammatory Agents, Non-Steroidal Early Phase 1
32 omega-N-Methylarginine Early Phase 1
33 Androgens Early Phase 1
34 Analgesics, Non-Narcotic Early Phase 1
35 Anti-Inflammatory Agents Early Phase 1
36 Analgesics Early Phase 1
37 Acidophilus

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Esmolol Reduces Anesthetic Requirements Thereby Facilitating Early Extubation; a Prospective Controlled Study in Patients Undergoing Intracranial Surgery Completed NCT02455440 Phase 3 Esmolol;Placebo;Propofol and sevoflurane
2 Evaluation of Dotarem-enhanced MRA Compared to Time-Of-Flight (TOF) MRA in the Diagnosis of Carotid and Vertebral Basilar Arterial Disease Completed NCT01012674 Phase 3 Dotarem
3 Evaluation of Dotarem-enhanced MRA Compared to Time-Of-Flight (TOF) MRA in the Diagnosis of Carotid and Vertebral Basilar Arterial Disease Completed NCT01010932 Phase 3 Dotarem
4 Modulation of Brain Blood Flow Using Dichoptic Visual and Auditory Stimulation Unknown status NCT03632564
5 Prospective Observation for Serial Changes of Acute Intracranial Artery Dissection Using High Resolution MRI Unknown status NCT02914288
6 Normal Values of Cerebral Oxygenation Completed NCT00512447
7 Human Cerebral Blood Flow Regulation: Sex, Mechanism, and Stress Differences Recruiting NCT04265053 Early Phase 1 L-NMMA;Ketorolac Tromethamine;Ganirelix Acetate;Testosterone Transdermal Product;Estradiol Topical
8 Acute Impact of Probiotic Supplementation on Endothelial Function in Adults Active, not recruiting NCT04364074

Search NIH Clinical Center for Cerebral Arterial Disease

Cochrane evidence based reviews: cerebral arterial diseases

Genetic Tests for Cerebral Arterial Disease

Anatomical Context for Cerebral Arterial Disease

Organs/tissues related to Cerebral Arterial Disease:

MalaCards : Endothelial, Brain, Liver

Publications for Cerebral Arterial Disease

Articles related to Cerebral Arterial Disease:

(show all 45)
# Title Authors PMID Year
1
Pathogenesis and Management in Cerebrovenous Outflow Disorders. 62
33532137 2021
2
Cerebral Small Vessel, But Not Large Vessel Disease, Is Associated With Impaired Cerebral Autoregulation During Cardiopulmonary Bypass: A Retrospective Cohort Study. 62
29677060 2018
3
Spectrum of cerebral arterial and venous abnormalities in Alagille syndrome. 62
29362841 2018
4
Effect of over-2-year dual antiplatelet therapy on the rate of major adverse cardiac and cerebral events for everolimus-eluting stent implantation: The landmark analysis from Tokyo-MD PCI registry. 62
27692568 2017
5
Frequency and Risk Factors for Cerebral Arterial Disease in a HIV/AIDS Neuroimaging Cohort. 62
26751784 2016
6
Intracranial arterial disease in CADASIL patients. 62
26671140 2015
7
Role of BK(Ca) channels in diabetic vascular complications. 62
24791890 2014
8
Improvements in the quantitative assessment of cerebral blood volume and flow with the removal of vessel voxels from MR perfusion images. 62
23586033 2013
9
Associations of ankle-brachial index (ABI) with cerebral arterial disease and vascular events following ischemic stroke. 62
22652527 2012
10
Assessment of pial branches using 7-tesla MRI in cerebral arterial disease. 62
20185908 2010
11
Receptor for advanced glycation end-products (RAGE) and soluble RAGE (sRAGE): cardiovascular implications. 62
19156622 2009
12
Preoperative transcranial and carotid Doppler study in coronary artery bypass graft patients. 62
21857617 2007
13
A rational connection of inflammation with peripheral arterial disease. 62
17555883 2007
14
Position Paper on urine alkalinization. 62
15083932 2004
15
Pharmacologic therapy for peripheral arterial disease and claudication. 62
12469066 2002
16
Isolated petrous carotid stenosis and transient ischemic attack. 62
11296591 2001
17
Coronary artery bypass grafting using the "Super Pulse" dynamic pulsatile cardiopulmonary bypass device in patients with cerebrovascular occlusive disease. 62
10899686 2000
18
[Speech activation SPECT measurements in the determination of hemispheric dominance]. 62
10647268 1999
19
Risk factors for stroke in different levels of cerebral arterial disease. 62
10529541 1999
20
Thrombotic events during oral anticoagulant treatment: results of the inception-cohort, prospective, collaborative ISCOAT study: ISCOAT study group (Italian Study on Complications of Oral Anticoagulant Therapy). 62
9423791 1997
21
Isolated cerebral thrombo-embolism and Crohn disease. 62
8529679 1995
22
Deleterious effects of salt intake other than effects on blood pressure. 62
7554410 1995
23
High prevalence of unsuspected abdominal aortic aneurysm in patients with confirmed symptomatic peripheral or cerebral arterial disease. 62
8518892 1993
24
Diabetic nephropathy in insulin-dependent patients. 62
1462980 1992
25
[20 years pentoxifylline: a part of recent angiology history]. 62
1475991 1992
26
Large-vessel occlusion in sickle cell disease: pathogenesis, clinical consequences, and therapeutic implications. 62
1890982 1991
27
[Cerebral infarction after coronary artery bypass surgery--its cause, management and prevention]. 62
1875899 1991
28
Papaverine-induced chronic liver disease. 62
3949106 1986
29
Brain revascularisation in hypertension. 62
4091584 1985
30
A case of internal carotid artery occlusion successfully treated by encephalo-duro-arterio-synangiosis. 62
3833339 1985
31
Measurement of carotid blood flow in man and its clinical application. 62
6220490 1983
32
Occlusive cerebral arterial disease. 62
6839323 1983
33
Epileptic seizures in cerebral arterial occlusive disease. 62
7064190 1982
34
A host of hypercholesterolaemic homozygotes in South Africa. 62
7437743 1980
35
Fibromuscular dysplasia in a child: a generalized arterial disease. 62
7446106 1980
36
[Quantitative analysis of lipoproteins in hyperlipoproteinemias of type IIa, IIb and IV (author's transl)]. 62
227624 1979
37
Circannual rhythm of arterial and venous thromboembolic disease. 62
555814 1979
38
Intracranial bypass surgery for cerebral arterial disease and the responsibility of the practicing physician. 62
462524 1979
39
Effect of ethyl apovincaminate on the cerebral circulation. Studies in patients with obliterative cerebral arterial disease. 62
1037221 1976
40
Measures of clinical efficacy. The value of case finding in hypertensive renovascular disease. 62
1143301 1975
41
Cerebral arterial disease in children. An angiographic study of 40 cases. 62
5579392 1971
42
The significance of naturally occurring coronary and cerebral arterial disease in animals. 62
5253796 1968
43
Cerebral strokes associated with pregnancy and the puerperium. 62
5662974 1968
44
Cerebral arterial disease. 62
14430850 1959
45
Cerebral arterial disease. 62
14417991 1959

Variations for Cerebral Arterial Disease

Expression for Cerebral Arterial Disease

Search GEO for disease gene expression data for Cerebral Arterial Disease.

Pathways for Cerebral Arterial Disease

Pathways related to Cerebral Arterial Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.13 MMP9 ELN EDN1
2 10.92 MIR145 MIR126 MIR125B1
3 10.39 PLG MMP9 ELN

GO Terms for Cerebral Arterial Disease

Cellular components related to Cerebral Arterial Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 RISC complex GO:0016442 9.93 MIR145 MIR144 MIR143 MIR126 MIR125B1 MIR125A
2 extracellular space GO:0005615 9.86 SERPINA3 PLG MMP9 MIR574 MIR144 MIR143
3 polycystin complex GO:0002133 8.92 PKD2 PKD1

Biological processes related to Cerebral Arterial Disease according to GeneCards Suite gene sharing:

(show all 16)
# Name GO ID Score Top Affiliating Genes
1 miRNA-mediated gene silencing GO:0035195 10.18 MIR574 MIR145 MIR144 MIR143 MIR126 MIR125B1
2 negative regulation of gene expression GO:0010629 10.01 MIR144 MIR125B1 MIR125A EDN1 CDKN2B-AS1
3 cytoplasmic sequestering of transcription factor GO:0042994 9.86 PKD2 PKD1
4 mesonephric duct development GO:0072177 9.81 PKD2 PKD1
5 mesonephric tubule development GO:0072164 9.76 PKD2 PKD1
6 metanephric ascending thin limb development GO:0072218 9.73 PKD2 PKD1
7 negative regulation of angiogenesis GO:0016525 9.71 MIR125A MIR125B1 MIR143 MIR145
8 cell-cell signaling by wnt GO:0198738 9.56 PKD2 PKD1
9 angiotensin-activated signaling pathway GO:0038166 9.55 MIR145 MIR143
10 negative regulation of receptor signaling pathway via STAT GO:1904893 9.52 MIR125B1 MIR125A
11 negative regulation of interleukin-6-mediated signaling pathway GO:0070104 9.49 MIR125B1 MIR125A
12 aorta smooth muscle tissue morphogenesis GO:0060414 9.48 MIR145 MIR143
13 regulation of phenotypic switching GO:1900239 9.32 MIR145 MIR143
14 establishment or maintenance of cell type involved in phenotypic switching GO:0044663 9.16 MIR145 MIR143
15 negative regulation of interleukin-16 production GO:0032699 8.96 MIR145 MIR125A
16 miRNA-mediated gene silencing by inhibition of translation GO:0035278 8.92 MIR145 MIR144 MIR126 MIR125B1

Molecular functions related to Cerebral Arterial Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 mRNA 3'-UTR binding GO:0003730 9.43 MIR145 MIR144 MIR143 MIR126 MIR125B1 MIR125A
2 mRNA base-pairing translational repressor activity GO:1903231 9.1 MIR145 MIR144 MIR143 MIR126 MIR125B1 MIR125A

Sources for Cerebral Arterial Disease

2 CDC
6 CNVD
8 Cosmic
9 dbSNP
10 DGIdb
16 EFO
17 ExPASy
18 FMA
19 GARD
27 GO
28 GTR
29 HMDB
30 HPO
31 ICD10
32 ICD10 via Orphanet
33 ICD11
34 ICD9CM
35 IUPHAR
36 LifeMap
38 LOVD
40 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
52 NINDS
53 Novoseek
55 ODiseA
56 OMIM via Orphanet
57 OMIM® (Updated 08-Dec-2022)
61 PubChem
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 Tocris
71 UMLS
72 UMLS via Orphanet
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