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MCID: CRB031
MIFTS: 28

Cerebral Arterial Disease

Categories: Cardiovascular diseases, Neuronal diseases
Genes Tissues Related diseases Publications Drugs
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Aliases & Classifications for Cerebral Arterial Disease

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MalaCards integrated aliases for Cerebral Arterial Disease:

Name: Cerebral Arterial Disease 12 15
Cerebral Arterial Diseases 44 73

Classifications:

MalaCards categories:
Anatomical: Cardiovascular diseases Neuronal diseases
See all MalaCards categories (disease lists)


External Ids:

Disease Ontology 12 DOID:3527
MeSH 44 D002539
UMLS 73 C0007774
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Summaries for Cerebral Arterial Disease

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MalaCards based summary : Cerebral Arterial Disease, also known as cerebral arterial diseases, is related to moyamoya disease 1 and aortic aneurysm. An important gene associated with Cerebral Arterial Disease is RNF213 (Ring Finger Protein 213). The drugs Abciximab and Piracetam have been mentioned in the context of this disorder. Affiliated tissues include bone marrow, bone and endothelial.

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Related Diseases for Cerebral Arterial Disease

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Diseases related to Cerebral Arterial Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 21)
# Related Disease Score Top Affiliating Genes
1 moyamoya disease 1 29.0 ACTA2 GUCY1A1 NF1 PCLO RNF213 RPSA
2 aortic aneurysm 28.7 ACTA2 CDKN2B-AS1 ELN
3 cerebral atherosclerosis 10.6 RNF213 RPSA
4 tolosa-hunt syndrome 10.4 NF1 RPSA
5 subclavian artery aneurysm 10.4 NF1 SLC25A16
6 vertebral artery occlusion 10.3 MRAS SLC25A16
7 stroke, ischemic 10.3
8 amyloid tumor 10.2 NF1 PKDREJ
9 hemiplegia 10.2 ACTA2 GUCY1A1 RNF213
10 arteries, anomalies of 10.2
11 cerebritis 10.2
12 plexiform neurofibroma 10.1 CDKN2B-AS1 NF1
13 elephantiasis 9.9 ELN NF1
14 neurofibromatosis, type i 9.9 CDKN2B-AS1 NF1
15 aortic aneurysm, familial abdominal, 1 9.6
16 osteoporosis 9.6
17 neuronitis 9.6
18 aneurysm 9.6
19 aortic aneurysm, familial thoracic 1 9.5 ACTA2 ELN
20 arteriovenous malformations of the brain 9.3 CDKN2B-AS1 SOX17
21 intracranial aneurysm 8.7 CDKN2B-AS1 ELN SOX17 THSD1

Graphical network of the top 20 diseases related to Cerebral Arterial Disease:



Diseases related to Cerebral Arterial Disease
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Symptoms & Phenotypes for Cerebral Arterial Disease

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Drugs & Therapeutics for Cerebral Arterial Disease

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Drugs for Cerebral Arterial Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show top 50) (show all 76)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Abciximab Approved Phase 4 143653-53-6
2 Piracetam Approved, Investigational Phase 4 7491-74-9
3 Antimetabolites Phase 4,Not Applicable
4 Hypolipidemic Agents Phase 4,Not Applicable
5 Lipid Regulating Agents Phase 4,Not Applicable
6 Anticoagulants Phase 4,Phase 2,Not Applicable
7 Fibrinolytic Agents Phase 4,Phase 3,Phase 2,Not Applicable
8 Platelet Aggregation Inhibitors Phase 4,Phase 3,Not Applicable
9 Tissue Plasminogen Activator Phase 4,Phase 3,Phase 2,Not Applicable
10 Plasminogen Phase 4,Phase 2,Not Applicable
11 Pharmaceutical Solutions Phase 4,Phase 2
12 Anticholesteremic Agents Phase 4
13 Calcium, Dietary Phase 4
14 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 4,Not Applicable
15 Rosuvastatin Calcium Phase 4 147098-20-2
16 Antibodies Phase 4
17 Antibodies, Monoclonal Phase 4
18 Immunoglobulin Fab Fragments Phase 4
19 Immunoglobulins Phase 4
20
Aspirin Approved, Vet_approved Phase 3 50-78-2 2244
21
Clopidogrel Approved Phase 3 120202-66-6, 113665-84-2 60606
22
Ticlopidine Approved Phase 3 55142-85-3 5472
23
Esmolol Approved Phase 3 103598-03-4, 81147-92-4 59768
24
Propofol Approved, Investigational, Vet_approved Phase 3 2078-54-8 4943
25
Sevoflurane Approved, Vet_approved Phase 3,Not Applicable 28523-86-6 5206
26
Xylometazoline Approved, Investigational Phase 3,Not Applicable 526-36-3 5709
27
Mannitol Approved, Investigational Phase 3,Not Applicable 69-65-8 453 6251
28 Analgesics Phase 3
29 Analgesics, Non-Narcotic Phase 3
30 Anti-Inflammatory Agents Phase 3
31 Anti-Inflammatory Agents, Non-Steroidal Phase 3
32 Antipyretics Phase 3
33 Antirheumatic Agents Phase 3
34 Cyclooxygenase Inhibitors Phase 3
35 Cytochrome P-450 Enzyme Inhibitors Phase 3
36 Neurotransmitter Agents Phase 3,Phase 2
37 Peripheral Nervous System Agents Phase 3
38 Purinergic P2 Receptor Antagonists Phase 3
39 Purinergic P2Y Receptor Antagonists Phase 3
40 Adrenergic Agents Phase 3
41 Adrenergic Antagonists Phase 3
42 Adrenergic beta-1 Receptor Antagonists Phase 3
43 Adrenergic beta-Antagonists Phase 3
44 Anesthetics Phase 3,Phase 1,Phase 2,Not Applicable
45 Anesthetics, General Phase 3,Not Applicable
46 Anesthetics, Inhalation Phase 3,Not Applicable
47 Anesthetics, Intravenous Phase 3
48 Central Nervous System Depressants Phase 3,Not Applicable
49 Hypnotics and Sedatives Phase 3
50 Epoetin alfa Phase 2, Phase 3,Phase 1 113427-24-0

Interventional clinical trials:

(show top 50) (show all 69)
# Name Status NCT ID Phase Drugs
1 Effect of Rosuvastatin on Prognosis of Clinical Response in Acute Ischemic Stroke Patients(REPAIRS) Not yet recruiting NCT02484027 Phase 4 Rosuvastatin
2 Thrombectomy Under Reopro Versus Alteplase to Treat Stoke Terminated NCT02016547 Phase 4 alteplase 0.9mg/kg (10% by IV bolus following by 90% by 1 hour IV drip)
3 A Study to Evaluate the Efficacy and Safety of Piracetam on Aphasia After Acute Ischemic Cerebral Artery Stroke Terminated NCT01883011 Phase 4 Piracetam
4 The Carotid and Middle Cerebral Artery Occlusion Surgery Study Unknown status NCT01758614 Phase 3 Aspirin;Clopidogrel
5 Ultrasound Enhanced Thrombolytic Therapy of Middle Cerebral Artery Occlusion Unknown status NCT00336596 Phase 3
6 Carotid and Vertebral Magnetic Resonance Angiography (MRA) Study Comparing Dotarem and Time Of Flight (TOF) Completed NCT01012674 Phase 3 Dotarem
7 Carotid and Vertebral Magnetic Resonance Angiography (MRA) Study Comparing Dotarem and Time Of Flight (TOF) Completed NCT01010932 Phase 3 Dotarem
8 Esmolol Infusion in Patients Undergoing Craniotomy Completed NCT02455440 Phase 3 Esmolol;Placebo;Propofol and sevoflurane
9 Multicenter Efficacy Study of Recombinant Human Erythropoietin in Acute Ischemic Stroke Completed NCT00604630 Phase 2, Phase 3 recombinant human erythropoietin alfa;0.9% NaCl
10 Application of Amyloid PET in Cerebral Amyloid Angiopathy Recruiting NCT03542656 Phase 3 amyloid PET
11 The Adult Hemorrhagic Moyamoya Surgery Study Active, not recruiting NCT02319980 Phase 3
12 Hemicraniectomy for Malignant Middle Cerebral Artery Infarction (HeMMI): A Single Center Randomized Controlled Clinical Trial Terminated NCT02002234 Phase 3
13 Decompressive Craniectomy In Malignant Middle Cerebral Artery Infarcts Terminated NCT00190203 Phase 3
14 Autologous Bone Marrow Stromal Cell and Endothelial Progenitor Cell Transplantation in Ischemic Stroke Unknown status NCT01468064 Phase 1, Phase 2
15 Intravenous Autologous Mesenchymal Stem Cells Transplantation to Treat Middle Cerebral Artery Infarct Unknown status NCT01461720 Phase 2
16 Safety Study of Dabigatran in CADASIL Unknown status NCT01361763 Phase 2 Dabigatran;Antiplatelets
17 Study Evaluating the Safety,Tolerability and Efficacy of PF-04360365 in Adults With Probable Cerebral Amyloid Angiopathy Completed NCT01821118 Phase 2
18 Multiple Burrhole Therapy With Erythropoietin for Unstable Moyamoya Completed NCT03162588 Phase 1, Phase 2 erythropoietin
19 Cerebril™ in Patients With Lobar Hemorrhage Related to Cerebral Amyloid Angiopathy Completed NCT00056238 Phase 2 NC-758 (Anti amyloidotic [Aß] agent)
20 Stem Cell Therapy For Acute Ischemic Stroke Patients Completed NCT02425670 Phase 2
21 Efficacy Study of CD34 Stem Cell in Chronic Stroke Patients Completed NCT00950521 Phase 2 convention therapy
22 Thrombolysis and Deferoxamine in Middle Cerebral Artery Occlusion Completed NCT00777140 Phase 2 Deferoxamine
23 Autologous Bone Marrow Stem Cells in Middle Cerebral Artery Acute Stroke Treatment. Completed NCT00761982 Phase 1, Phase 2
24 Autologous Bone Marrow Stem Cells in Ischemic Stroke. Completed NCT00535197 Phase 1, Phase 2
25 The Efficacy, Safety, And Tolerability Of Donepezil HCl (E2020) In Patients With CADASIL Who Have Cognitive Impairment Completed NCT00103948 Phase 2 Aricept
26 Study of Human Placenta-derived Cells (PDA001) to Evaluate the Safety and Effectiveness for Patients With Ischemic Stroke Terminated NCT01310114 Phase 2 Placebo
27 The Efficacy and Safety of MK0724 IV for Improvement of Neurological Damage and Recovery From Middle Cerebral Artery Ischemic Stroke (0724-018) Terminated NCT00401310 Phase 2 Comparator: Placebo;Comparator: MK0724
28 Superiority of Rt-PA + Tenecteplase in Comparison With Rt-PA Only in Proximal Middle Cerebral Artery Occlusion Withdrawn NCT02338466 Phase 2 rt-PA;tenecteplase
29 Study of Purified Umbilical Cord Blood CD34+ Stem Cell on Chronic Ischemic Stroke Unknown status NCT01438593 Phase 1
30 Implantation of Olfactory Ensheathing Cells (OECs) Unknown status NCT01327768 Phase 1
31 Intraarterial Stem Cells in Subacute Ischemic Stroke Completed NCT03080571 Phase 1
32 Study of Autologous Stem Cell Transplantation for Patients With Ischemic Stroke Completed NCT00473057 Phase 1
33 Characteristics and Outcomes of Childhood Moyamoya in the UK Unknown status NCT02434302
34 Methods of Etiological Diagnosis of Cerebral Amyloid Angiopathy Unknown status NCT02361411
35 Subclavian Vein catheterization_Seldinger Vs Modified Seldinger Unknown status NCT02090010 Not Applicable
36 Imaging Study of Neurovascular Coupling in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Unknown status NCT02071784
37 Normal Values of Brain Oxygenation Completed NCT00512447
38 Longitudinal Study of Neurologic, Cognitive, and Radiologic Outcomes of PHACE Syndrome Completed NCT01018082
39 Pulse Wave Velocity as a Predictor for Postoperative Cardiovascular Events Completed NCT03223441
40 Intracranial Pressure After Decompressive Craniectomy Completed NCT03364634
41 Effects of Remote Ischemic Preconditioning With Postconditioning on Neurologic Outcome Completed NCT03072914 Not Applicable
42 The Silent Cortical Infarcts in the Cerebral Amyloid Angiopathy: Is There a Link With Subarachnoid Hemorrhage? Completed NCT02837354
43 A Comparison Between Two Techniques for Performing Decompressive Craniectomy Completed NCT02594137 Not Applicable
44 Impact of tDCS on Cerebral Autoregulation Completed NCT01865604 Not Applicable
45 Quantifying Collateral Perfusion in Cerebrovascular Disease-Moyamoya Disease and Stroke Patients Completed NCT01419275 Not Applicable Xenon contrast agent
46 Research Study on Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) Completed NCT01114815
47 Impact of Cranioplasty On Cerebral Perfusion Completed NCT01113645
48 The Role of Cerebral Hemodynamics in Moyamoya Disease Completed NCT00629915
49 Gait Training for Persons With Stroke Completed NCT00612300 Early Phase 1
50 Prospective Observation for Serial Changes of Acute Intracranial Artery Dissection Using High Resolution MRI Recruiting NCT02914288

Search NIH Clinical Center for Cerebral Arterial Disease

Cochrane evidence based reviews: cerebral arterial diseases

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Genetic Tests for Cerebral Arterial Disease

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Anatomical Context for Cerebral Arterial Disease

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MalaCards organs/tissues related to Cerebral Arterial Disease:

41
Bone Marrow, Bone, Endothelial, Brain, Skin
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Publications for Cerebral Arterial Disease

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Articles related to Cerebral Arterial Disease:

(show all 16)
# Title Authors Year
1
Association factor analysis between osteoporosis with cerebral artery disease: The STROBE study. ( 28248870 )
2017
2
Frequency and Risk Factors for Cerebral Arterial Disease in a HIV/AIDS Neuroimaging Cohort. ( 26751784 )
2016
3
Nonatheroscleotic Isolated Middle Cerebral Artery Disease May Be Early Manifestation of Moyamoya Disease. ( 27507861 )
2016
4
Progressive Cortical Neuronal Damage and Chronic Hemodynamic Impairment in Atherosclerotic Major Cerebral Artery Disease. ( 27217506 )
2016
5
Misery Perfusion, Blood Pressure Control, and 5-Year Stroke Risk in Symptomatic Major Cerebral Artery Disease. ( 25395413 )
2014
6
Associations of ankle-brachial index (ABI) with cerebral arterial disease and vascular events following ischemic stroke. ( 22652527 )
2012
7
Assessment of pial branches using 7-tesla MRI in cerebral arterial disease. ( 20185908 )
2010
8
Risk factors for stroke in different levels of cerebral arterial disease. ( 10529541 )
1999
9
High prevalence of unsuspected abdominal aortic aneurysm in patients with confirmed symptomatic peripheral or cerebral arterial disease. ( 8518892 )
1993
10
Occlusive cerebral arterial disease. ( 6839323 )
1983
11
Intracranial bypass surgery for cerebral arterial disease and the responsibility of the practicing physician. ( 462524 )
1979
12
Effect of ethyl apovincaminate on the cerebral circulation. Studies in patients with obliterative cerebral arterial disease. ( 1037221 )
1976
13
Cerebral arterial disease in children. An angiographic study of 40 cases. ( 5579392 )
1971
14
The significance of naturally occurring coronary and cerebral arterial disease in animals. ( 5253796 )
1968
15
Cerebral arterial disease. ( 14430850 )
1959
16
Cerebral arterial disease. ( 14417991 )
1959
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Variations for Cerebral Arterial Disease

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Expression for Cerebral Arterial Disease

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Search GEO for disease gene expression data for Cerebral Arterial Disease.
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Pathways for Cerebral Arterial Disease

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GO Terms for Cerebral Arterial Disease

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Biological processes related to Cerebral Arterial Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 blood circulation GO:0008015 8.62 ELN GUCY1A1
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Sources for Cerebral Arterial Disease

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3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 SNOMED-CT via Orphanet
71 TGDB
72 Tocris
73 UMLS
74 UMLS via Orphanet
The MalaCards human disease database index: 1-9 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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