MCID: CRB031
MIFTS: 30

Cerebral Arterial Disease

Categories: Cardiovascular diseases, Neuronal diseases

Aliases & Classifications for Cerebral Arterial Disease

MalaCards integrated aliases for Cerebral Arterial Disease:

Name: Cerebral Arterial Disease 12 15 17
Cerebral Arterial Diseases 44 72

Classifications:



External Ids:

Disease Ontology 12 DOID:3527
MeSH 44 D002539
UMLS 72 C0007774

Summaries for Cerebral Arterial Disease

MalaCards based summary : Cerebral Arterial Disease, also known as cerebral arterial diseases, is related to moyamoya disease 1 and arteries, anomalies of. An important gene associated with Cerebral Arterial Disease is RNF213 (Ring Finger Protein 213), and among its related pathways/superpathways are MAP Kinase Signaling and A-beta Pathways: Plaque Formation and APP Metabolism. The drugs Propofol and Sevoflurane have been mentioned in the context of this disorder. Affiliated tissues include brain and liver.

Related Diseases for Cerebral Arterial Disease

Diseases related to Cerebral Arterial Disease via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 44)
# Related Disease Score Top Affiliating Genes
1 moyamoya disease 1 32.8 RNF213 NF1 ACTA2
2 arteries, anomalies of 31.0 PLG NOS3 MMP9
3 stroke, ischemic 30.0 TSPAN33 PLG NOS3 CDKN2B-AS1
4 aortic aneurysm 29.7 ELN CDKN2B-AS1 ACTA2
5 carotid stenosis 29.7 S100B MMP9 CDKN2B-AS1
6 aortic aneurysm, familial abdominal, 1 29.6 MMP9 ELN CDKN2B-AS1
7 intracranial aneurysm 29.0 THSD1 SOX17 NOS3 ELN CDKN2B-AS1
8 vascular disease 28.5 PLG NOS3 MMP9 MIR145 MIR143 ELN
9 amusia 10.5 PLG NF1
10 subclavian artery aneurysm 10.5 SLC25A16 NF1
11 central retinal artery occlusion 10.5 PLG ACTA2
12 malignant triton tumor 10.5 S100B NF1
13 lentigo maligna melanoma 10.4 S100B MMP9
14 epithelioid malignant peripheral nerve sheath tumor 10.4 S100B NF1
15 chronic actinic dermatitis 10.3 MMP9 ELN
16 odontogenic myxoma 10.3 SERPINA3 S100B MMP9
17 ovarian serous carcinoma 10.3 MIR145 MIR143
18 senile ectropion 10.3 MMP9 ELN
19 anaplastic ependymoma 10.3 S100B RNF213
20 cutaneous fibrous histiocytoma 10.2 SERPINA3 S100B
21 elephantiasis 10.2 NF1 ELN
22 plexiform neurofibroma 10.2 NF1 CDKN2B-AS1
23 aortic disease 10.2 MMP9 ELN ACTA2
24 inguinal hernia 10.1 NF1 MMP9 ELN
25 nervous system disease 10.1 S100B PLG MMP9
26 intracranial vasospasm 10.0 TSPAN33 NOS3
27 endometriosis 10.0 MIR145 MIR143 CDKN2B-AS1
28 carotid artery disease 9.9
29 cerebrovascular disease 9.9
30 vertebral artery occlusion 9.9 SLC25A16 PLG MRAS FOSB
31 acute myocardial infarction 9.9 PLG MMP9 CDKN2B-AS1
32 coronary heart disease 1 9.9 NOS3 MIR145 CDKN2B-AS1
33 peripheral vascular disease 9.8
34 vasculitis 9.8
35 osteoporosis 9.7
36 arterial calcification, generalized, of infancy, 1 9.7
37 bone mineral density quantitative trait locus 8 9.7
38 bone mineral density quantitative trait locus 15 9.7
39 transient cerebral ischemia 9.7
40 carotid artery occlusion 9.7
41 subacute delirium 9.7
42 pulmonary disease, chronic obstructive 9.6 SERPINA3 MMP9 ELN
43 myocardial infarction 9.6 S100B PLG NOS3 MMP9 CDKN2B-AS1
44 basilar artery occlusion 8.9 TSPAN33 SLC25A16 PLG MRS2 FOSB

Graphical network of the top 20 diseases related to Cerebral Arterial Disease:



Diseases related to Cerebral Arterial Disease

Symptoms & Phenotypes for Cerebral Arterial Disease

Drugs & Therapeutics for Cerebral Arterial Disease

Drugs for Cerebral Arterial Disease (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 21)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Propofol Approved, Investigational, Vet_approved Phase 3 2078-54-8 4943
2
Sevoflurane Approved, Vet_approved Phase 3 28523-86-6 5206
3
Esmolol Approved Phase 3 103598-03-4, 81147-92-4 59768
4 Neurotransmitter Agents Phase 3
5 Adrenergic beta-Antagonists Phase 3
6 Adrenergic beta-1 Receptor Antagonists Phase 3
7 Central Nervous System Depressants Phase 3
8 Adrenergic Antagonists Phase 3
9 Hypnotics and Sedatives Phase 3
10 Anesthetics Phase 3
11 Anesthetics, General Phase 3
12 Adrenergic Agents Phase 3
13 Platelet Aggregation Inhibitors Phase 3
14 Anesthetics, Inhalation Phase 3
15 Anesthetics, Intravenous Phase 3
16
Atorvastatin Approved 134523-00-5 60823
17 Lipid Regulating Agents
18 Hydroxymethylglutaryl-CoA Reductase Inhibitors
19 Anticholesteremic Agents
20 Hypolipidemic Agents
21 Antimetabolites

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Esmolol Reduces Anesthetic Requirements Thereby Facilitating Early Extubation; a Prospective Controlled Study in Patients Undergoing Intracranial Surgery Completed NCT02455440 Phase 3 Esmolol;Placebo;Propofol and sevoflurane
2 Evaluation of Dotarem-enhanced MRA Compared to Time-Of-Flight (TOF) MRA in the Diagnosis of Carotid and Vertebral Basilar Arterial Disease Completed NCT01012674 Phase 3 Dotarem
3 Evaluation of Dotarem-enhanced MRA Compared to Time-Of-Flight (TOF) MRA in the Diagnosis of Carotid and Vertebral Basilar Arterial Disease Completed NCT01010932 Phase 3 Dotarem
4 Prospective Observation for Serial Changes of Acute Intracranial Artery Dissection Using High Resolution MRI Unknown status NCT02914288
5 Normal Values of Cerebral Oxygenation Completed NCT00512447
6 Longitudinal Study of Neurologic, Cognitive, and Radiologic Outcomes in PHACE Syndrome Completed NCT01018082
7 Effect of Atorvastatin on Glycemic Control in Prediabetic Patients Completed NCT02470455 Atorvastatin
8 Modulation of Brain Blood Flow Using Dichoptic Visual and Auditory Stimulation Not yet recruiting NCT03632564
9 Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke II (VERiTASII) Not yet recruiting NCT03729817

Search NIH Clinical Center for Cerebral Arterial Disease

Cochrane evidence based reviews: cerebral arterial diseases

Genetic Tests for Cerebral Arterial Disease

Anatomical Context for Cerebral Arterial Disease

MalaCards organs/tissues related to Cerebral Arterial Disease:

41
Brain, Liver

Publications for Cerebral Arterial Disease

Articles related to Cerebral Arterial Disease:

(show all 48)
# Title Authors PMID Year
1
Cerebral Small Vessel, But Not Large Vessel Disease, Is Associated With Impaired Cerebral Autoregulation During Cardiopulmonary Bypass: A Retrospective Cohort Study. 38
29677060 2018
2
Spectrum of cerebral arterial and venous abnormalities in Alagille syndrome. 38
29362841 2018
3
Effect of over-2-year dual antiplatelet therapy on the rate of major adverse cardiac and cerebral events for everolimus-eluting stent implantation: The landmark analysis from Tokyo-MD PCI registry. 38
27692568 2017
4
Frequency and Risk Factors for Cerebral Arterial Disease in a HIV/AIDS Neuroimaging Cohort. 38
26751784 2016
5
Intracranial arterial disease in CADASIL patients. 38
26671140 2015
6
Role of BK(Ca) channels in diabetic vascular complications. 38
24791890 2014
7
Improvements in the quantitative assessment of cerebral blood volume and flow with the removal of vessel voxels from MR perfusion images. 38
23586033 2013
8
Associations of ankle-brachial index (ABI) with cerebral arterial disease and vascular events following ischemic stroke. 38
22652527 2012
9
Assessment of pial branches using 7-tesla MRI in cerebral arterial disease. 38
20185908 2010
10
Receptor for advanced glycation end-products (RAGE) and soluble RAGE (sRAGE): cardiovascular implications. 38
19156622 2009
11
Preoperative transcranial and carotid Doppler study in coronary artery bypass graft patients. 38
21857617 2007
12
A rational connection of inflammation with peripheral arterial disease. 38
17555883 2007
13
Targeting cerebral arteries for gene therapy. 38
15778412 2005
14
Position Paper on urine alkalinization. 38
15083932 2004
15
Pharmacologic therapy for peripheral arterial disease and claudication. 38
12469066 2002
16
Isolated petrous carotid stenosis and transient ischemic attack. 38
11296591 2001
17
Coronary artery bypass grafting using the "Super Pulse" dynamic pulsatile cardiopulmonary bypass device in patients with cerebrovascular occlusive disease. 38
10899686 2000
18
[Speech activation SPECT measurements in the determination of hemispheric dominance]. 38
10647268 1999
19
Risk factors for stroke in different levels of cerebral arterial disease. 38
10529541 1999
20
Thrombotic events during oral anticoagulant treatment: results of the inception-cohort, prospective, collaborative ISCOAT study: ISCOAT study group (Italian Study on Complications of Oral Anticoagulant Therapy). 38
9423791 1997
21
Isolated cerebral thrombo-embolism and Crohn disease. 38
8529679 1995
22
Deleterious effects of salt intake other than effects on blood pressure. 38
7554410 1995
23
High prevalence of unsuspected abdominal aortic aneurysm in patients with confirmed symptomatic peripheral or cerebral arterial disease. 38
8518892 1993
24
Diabetic nephropathy in insulin-dependent patients. 38
1462980 1992
25
[20 years pentoxifylline: a part of recent angiology history]. 38
1475991 1992
26
Large-vessel occlusion in sickle cell disease: pathogenesis, clinical consequences, and therapeutic implications. 38
1890982 1991
27
[Cerebral infarction after coronary artery bypass surgery--its cause, management and prevention]. 38
1875899 1991
28
Basis for an international classification of cerebral arterial diseases. 38
3488419 1986
29
Papaverine-induced chronic liver disease. 38
3949106 1986
30
Brain revascularisation in hypertension. 38
4091584 1985
31
A case of internal carotid artery occlusion successfully treated by encephalo-duro-arterio-synangiosis. 38
3833339 1985
32
[Hemofiltration in peripheral and cerebral arterial diseases]. 38
6521947 1984
33
Measurement of carotid blood flow in man and its clinical application. 38
6220490 1983
34
Occlusive cerebral arterial disease. 38
6839323 1983
35
Epileptic seizures in cerebral arterial occlusive disease. 38
7064190 1982
36
A host of hypercholesterolaemic homozygotes in South Africa. 38
7437743 1980
37
Fibromuscular dysplasia in a child: a generalized arterial disease. 38
7446106 1980
38
[Quantitative analysis of lipoproteins in hyperlipoproteinemias of type IIa, IIb and IV (author's transl)]. 38
227624 1979
39
Circannual rhythm of arterial and venous thromboembolic disease. 38
555814 1979
40
Intracranial bypass surgery for cerebral arterial disease and the responsibility of the practicing physician. 38
462524 1979
41
Effect of ethyl apovincaminate on the cerebral circulation. Studies in patients with obliterative cerebral arterial disease. 38
1037221 1976
42
Measures of clinical efficacy. The value of case finding in hypertensive renovascular disease. 38
1143301 1975
43
Cerebral arterial disease in children. An angiographic study of 40 cases. 38
5579392 1971
44
[Cerebral arterial diseases]. 38
5390410 1969
45
The significance of naturally occurring coronary and cerebral arterial disease in animals. 38
5253796 1968
46
Cerebral strokes associated with pregnancy and the puerperium. 38
5662974 1968
47
Cerebral arterial disease. 38
14417991 1959
48
Cerebral arterial disease. 38
14430850 1959

Variations for Cerebral Arterial Disease

Expression for Cerebral Arterial Disease

Search GEO for disease gene expression data for Cerebral Arterial Disease.

Pathways for Cerebral Arterial Disease

Pathways related to Cerebral Arterial Disease according to GeneCards Suite gene sharing:

# Super pathways Score Top Affiliating Genes
1 11.18 NF1 MRAS FOSB
2 10.52 PLG MMP9
3 10.39 PLG MMP9 ELN

GO Terms for Cerebral Arterial Disease

Cellular components related to Cerebral Arterial Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 collagen-containing extracellular matrix GO:0062023 8.92 SERPINA3 PLG MMP9 ELN

Biological processes related to Cerebral Arterial Disease according to GeneCards Suite gene sharing:

# Name GO ID Score Top Affiliating Genes
1 negative regulation of angiogenesis GO:0016525 9.58 NF1 MIR145 MIR143
2 actin cytoskeleton organization GO:0030036 9.56 NF1 MRAS MIR145 MIR143
3 aortic valve morphogenesis GO:0003180 9.43 NOS3 ELN
4 regulation of smooth muscle contraction GO:0006940 9.37 MIR145 MIR143
5 angiotensin-activated signaling pathway GO:0038166 9.32 MIR145 MIR143
6 aorta smooth muscle tissue morphogenesis GO:0060414 9.16 MIR145 MIR143
7 regulation of phenotypic switching GO:1900239 8.96 MIR145 MIR143
8 establishment or maintenance of cell type involved in phenotypic switching GO:0044663 8.62 MIR145 MIR143

Sources for Cerebral Arterial Disease

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HGMD
31 HMDB
32 HPO
33 ICD10
34 ICD10 via Orphanet
35 ICD9CM
36 IUPHAR
37 KEGG
38 LifeMap
40 LOVD
42 MedGen
44 MeSH
45 MESH via Orphanet
46 MGI
49 NCI
50 NCIt
51 NDF-RT
54 NINDS
55 Novoseek
57 OMIM
58 OMIM via Orphanet
62 PubMed
64 QIAGEN
69 SNOMED-CT via HPO
70 TGDB
71 Tocris
72 UMLS
73 UMLS via Orphanet
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