MCID: CRB087
MIFTS: 22

Cerebral Arteriosclerosis

Categories: Blood diseases, Neuronal diseases

Aliases & Classifications for Cerebral Arteriosclerosis

MalaCards integrated aliases for Cerebral Arteriosclerosis:

Name: Cerebral Arteriosclerosis 55 74

Classifications:



External Ids:

UMLS 74 C0877854

Summaries for Cerebral Arteriosclerosis

NINDS : 55 Cerebral arteriosclerosis is the result of thickening and hardening of the walls of the arteries in the brain. Symptoms of cerebral arteriosclerosis include headache, facial pain, and impaired vision. Cerebral arteriosclerosis can cause serious health problems. If the walls of an artery are too thick, or a blood clot becomes caught in the narrow passage, blood flow to the brain can become blocked and cause an ischemic stroke. When the thickening and hardening is uneven, arterial walls can develop bulges (called aneurysms). If a bulge ruptures, bleeding in the brain can cause a hemorrhagic stroke. Both types of stroke can be fatal. Cerebral arteriosclerosis is also related to a condition known as vascular dementia, in which small, symptom-free strokes cause cumulative damage and death to neurons (nerve cells) in the brain. Personality changes in the elderly, such as apathy, weeping, transient befuddlement, or irritability, might indicate that cerebral arteriosclerosis is present in the brain. Computer tomography (CT) and magnetic resonance imaging (MRI) of the brain can help reveal the presence of cerebral arteriosclerosis before ischemic strokes, hemorrhagic strokes, or vascular dementia develop.

MalaCards based summary : Cerebral Arteriosclerosis is related to arteriosclerosis and diabetes mellitus. An important gene associated with Cerebral Arteriosclerosis is CALCA (Calcitonin Related Polypeptide Alpha). The drugs Aspirin and Lisinopril have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and heart.

Related Diseases for Cerebral Arteriosclerosis

Diseases related to Cerebral Arteriosclerosis via text searches within MalaCards or GeneCards Suite gene sharing:

(show all 13)
# Related Disease Score Top Affiliating Genes
1 arteriosclerosis 10.8
2 diabetes mellitus 10.0
3 dementia 10.0
4 hypertensive encephalopathy 10.0
5 encephalopathy 10.0
6 alzheimer disease 9.8
7 meniere disease 9.8
8 schizophrenia 9.8
9 ischemic heart disease 9.8
10 bronchopneumonia 9.8
11 arteriosclerosis obliterans 9.8
12 meningitis 9.8
13 tuberculous meningitis 9.8

Graphical network of the top 20 diseases related to Cerebral Arteriosclerosis:



Diseases related to Cerebral Arteriosclerosis

Symptoms & Phenotypes for Cerebral Arteriosclerosis

Drugs & Therapeutics for Cerebral Arteriosclerosis

Drugs for Cerebral Arteriosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 26)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Aspirin Approved, Vet_approved Phase 4,Phase 2 50-78-2 2244
2
Lisinopril Approved, Investigational Phase 4 83915-83-7, 76547-98-3 5362119
3
Propranolol Approved, Investigational Phase 4 525-66-6 4946
4
Atenolol Approved Phase 4 29122-68-7 2249
5
Metoprolol Approved, Investigational Phase 4 37350-58-6, 51384-51-1 4171
6 Adrenergic Antagonists Phase 4
7 Adrenergic beta-Antagonists Phase 4
8 HIV Protease Inhibitors Phase 4
9
protease inhibitors Phase 4
10 Angiotensin-Converting Enzyme Inhibitors Phase 4
11 Neurotransmitter Agents Phase 4
12 Adrenergic Agents Phase 4
13 Platelet Aggregation Inhibitors Phase 4
14
Nicotinamide Approved, Investigational Phase 3 98-92-0 936
15
Colestipol Approved Phase 3 26658-42-4
16
Niacin Approved, Investigational, Nutraceutical Phase 3 59-67-6 938
17 Vitamin B3 Phase 3
18 Lipid Regulating Agents Phase 3,Phase 2
19 Nicotinic Acids Phase 3
20 Hypolipidemic Agents Phase 3,Phase 2
21 Antimetabolites Phase 3,Phase 2
22
Lovastatin Approved, Investigational Phase 2 75330-75-5 53232
23 Hydroxymethylglutaryl-CoA Reductase Inhibitors Phase 2
24 Anticholesteremic Agents Phase 2
25 L 647318 Phase 2
26 Dihydromevinolin Phase 2

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Reducing Total Cardiovascular Risk in an Urban Community Completed NCT00241904 Phase 4 Antiplatelet Agents;Beta Blocker;ACE Inhibitors
2 Cholesterol-Lowering Atherosclerosis Study (CLAS) Completed NCT00000599 Phase 3 colestipol;niacin
3 Asymptomatic Carotid Artery Plaque Study (ACAPS) Completed NCT00000469 Phase 2 aspirin;lovastatin
4 Combined Coronary and Cerebral Angiography and Intervention for Coronary and Cerebrovascular Atherosclerosis Unknown status NCT02315924 Not Applicable
5 Boston Scientific Embolic Protection, Inc. (EPI): A Carotid Stenting Trial for High-Risk Surgical Patients (BEACH) Completed NCT00316108 Not Applicable
6 Epidemiology of Vascular Inflammation & Atherosclerosis Completed NCT00087893
7 Gene-by-Smoking Interactions and Risk of Atherosclerosis - Ancillary to ARIC Completed NCT00064545

Search NIH Clinical Center for Cerebral Arteriosclerosis

Genetic Tests for Cerebral Arteriosclerosis

Anatomical Context for Cerebral Arteriosclerosis

MalaCards organs/tissues related to Cerebral Arteriosclerosis:

42
Brain, Testes, Heart

Publications for Cerebral Arteriosclerosis

Articles related to Cerebral Arteriosclerosis:

(show top 50) (show all 96)
# Title Authors Year
1
The clinical research for Ganoderan's effect on preventing and treating cerebral arteriosclerosis through inhibiting NADPH oxidizing enzyme expression. ( 25016275 )
2014
2
[Clinical observation on effect of yangxue qingnao granule in treating patients with cerebral arteriosclerosis]. ( 15074084 )
2004
3
Cerebral arteriosclerosis in an aged captive polar bear (Ursus maritimus). ( 12564538 )
2002
4
The relationship between endothelin-1, event-related P300 potentials, and prognosis in cerebral arteriosclerosis. ( 9100710 )
1997
5
Risk factors for cerebral arteriosclerosis in Parkinson's disease. ( 18591022 )
1996
6
Effect of propentofylline and pentoxifylline on cerebral blood flow using 123I-IMP SPECT in patients with cerebral arteriosclerosis. ( 8205602 )
1994
7
Interrelation of coronary and cerebral arteriosclerosis. ( 1838872 )
1991
8
Acupuncture treatment of 60 cases of numbness due to cerebral arteriosclerosis. ( 2630808 )
1989
9
Delusional parasitosis. A comparative study to late-onset schizophrenia and organic mental disorders due to cerebral arteriosclerosis. ( 3237953 )
1988
10
Quantitative detection of cerebral arteriosclerosis by means of the Doppler ultrasonic technique. ( 3525327 )
1986
11
Extracranial vertebral artery rheoencephalography in the diagnosis of cerebral arteriosclerosis in middle aged and aged patients. ( 3924499 )
1985
12
A new model of cerebral arteriosclerosis induced by intimal injury using a silicone rubber cylinder in rabbits. ( 6482389 )
1984
13
DEM and cerebral arteriosclerosis. ( 6875159 )
1983
14
Effect of cardiac glycosides on the release of adenylate kinase into cerebrospinal fluid of patients with cerebral arteriosclerosis. ( 6288388 )
1982
15
A controlled, double-blind study of dl-alpha-tocopheryl nicotinate (Juvela-Nicotinate) for treatment of symptoms in hypertension and cerebral arteriosclerosis. ( 881743 )
1977
16
Generalized muscle stiffness in cerebral arteriosclerosis. Report of an anatomo-clinical case. ( 882811 )
1977
17
The use of prodectin in the treatment of cerebral arteriosclerosis and its complications. ( 790631 )
1976
18
Early manifestations and investigation of cerebral arteriosclerosis. ( 792862 )
1976
19
Cyclandelate in the treatment of cerebral arteriosclerosis. ( 811704 )
1976
20
Quantitative detection of cerebral arteriosclerosis by means of the pressure-velocity hysteresis technique. ( 966362 )
1976
21
Cerebral arteriosclerosis. ( 1039565 )
1975
22
Double-blind trial of naftidrofuryl in the treatment of cerebral arteriosclerosis. ( 4604345 )
1974
23
Hydergine for cerebral arteriosclerosis. ( 4204775 )
1974
24
A double-blind evaluation of 'Hydergine' and placebo in the treatment of patients with organic brain syndrome and cerebral arteriosclerosis in a nursing home. ( 4217240 )
1974
25
Parkinson's disease, cerebral arteriosclerosis, and senile dementia. Clinical features and response to levodopa. ( 4822972 )
1974
26
Results obtained with Sturgeron applied in progressive cerebral arteriosclerosis patients controlled systematically for years. ( 4844929 )
1974
27
Patient care study; cerebral arteriosclerosis. ( 4489058 )
1973
28
About 3 old men: an inquiry into how cerebral arteriosclerosis has altered world politics. A neurologist's view. (Woodrow Wilson, Paul von Hindenberg, and Nikolai Lenin). ( 4261795 )
1972
29
Juvenile cerebral arteriosclerosis and other cerebral arteriopathies of childhood--six autopsied cases. ( 4561249 )
1972
30
Long-term management of symptoms of cerebral arteriosclerosis. ( 4253476 )
1971
31
Cerebral arteriosclerosis. A non-cause of dementia. ( 5277475 )
1971
32
Management of chronic brain syndrome secondary to cerebral arteriosclerosis, with special reference to papaverine hydrochloride. ( 4910976 )
1970
33
Cyclandelate in long standing cerebral arteriosclerosis. ( 4987660 )
1970
34
The significance of diffuse slow activity in the EEG in cerebral arteriosclerosis. ( 4183391 )
1969
35
Manifestations of cerebral arteriosclerosis unaffected by a vasodilator. ( 4391604 )
1969
36
The metabolism of glucose and other metabolites in the brain of patients with cerebral arteriosclerosis and of patients with diabetes mellitus. ( 5687879 )
1968
37
Study of the effect of N-methyl carbamate on the electroencephalogram in cerebral arteriosclerosis. ( 5299490 )
1967
38
Sex differences in electroencephalograms and in cerebral arteriosclerosis. ( 5634060 )
1967
39
Measurement of cerebral blood flow by ultrasonic doppler technique. Quantitative detection of cerebral arteriosclerosis. ( 6072716 )
1967
40
ANTICOAGULANTS FOR CEREBRAL ARTERIOSCLEROSIS. ( 14246682 )
1965
41
ESTROGEN TREATMENT OF PATIENTS WITH CHRONIC BRAIN SYNDROME ASSOCIATED WITH CEREBRAL ARTERIOSCLEROSIS. ( 14327479 )
1965
42
THE VALUE OF PSYCHOLOGICAL TESTING AND VALIDITY OF DIAGNOSIS IN CEREBRAL ARTERIOSCLEROSIS. ( 14241357 )
1964
43
The value of cosaldon in cerebral arteriosclerosis. ( 13962885 )
1963
44
The diagnosis of cerebral arteriosclerosis. ( 13989662 )
1963
45
Carotid and cerebral arteriosclerosis in the rat. ( 14000169 )
1963
46
The effects of isoxsuprine hydrochloride (Vasodilan) on chronic cerebral arteriosclerosis. ( 13681562 )
1961
47
Effect of niacin on the electroencephalogram of psychosis with cerebral arteriosclerosis. ( 13524114 )
1958
48
Treatment of cerebral arteriosclerosis. ( 13540594 )
1958
49
Cerebral arteriosclerosis; survey of 500 psychotic patients with cerebral arteriosclerosis. ( 13327198 )
1956
50
Chronic subdural hematoma in the guise of cerebral arteriosclerosis. ( 13334834 )
1956

Variations for Cerebral Arteriosclerosis

Expression for Cerebral Arteriosclerosis

Search GEO for disease gene expression data for Cerebral Arteriosclerosis.

Pathways for Cerebral Arteriosclerosis

GO Terms for Cerebral Arteriosclerosis

Sources for Cerebral Arteriosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
20 FMA
29 GO
30 GTR
31 HGMD
32 HMDB
33 HPO
34 ICD10
35 ICD10 via Orphanet
36 ICD9CM
37 IUPHAR
38 KEGG
39 LifeMap
41 LOVD
43 MedGen
45 MeSH
46 MESH via Orphanet
47 MGI
50 NCI
51 NCIt
52 NDF-RT
55 NINDS
56 Novoseek
58 OMIM
59 OMIM via Orphanet
63 PubMed
65 QIAGEN
70 SNOMED-CT via HPO
71 SNOMED-CT via Orphanet
72 TGDB
73 Tocris
74 UMLS
75 UMLS via Orphanet
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