MCID: CRB087
MIFTS: 22

Cerebral Arteriosclerosis

Categories: Blood diseases, Neuronal diseases

Aliases & Classifications for Cerebral Arteriosclerosis

MalaCards integrated aliases for Cerebral Arteriosclerosis:

Name: Cerebral Arteriosclerosis 53 71

Classifications:



External Ids:

UMLS 71 C0877854

Summaries for Cerebral Arteriosclerosis

NINDS : 53 Cerebral arteriosclerosis is the result of thickening and hardening of the walls of the arteries in the brain. Symptoms of cerebral arteriosclerosis include headache, facial pain, and impaired vision. Cerebral arteriosclerosis can cause serious health problems. If the walls of an artery are too thick, or a blood clot becomes caught in the narrow passage, blood flow to the brain can become blocked and cause an ischemic stroke. When the thickening and hardening is uneven, arterial walls can develop bulges (called aneurysms). If a bulge ruptures, bleeding in the brain can cause a hemorrhagic stroke. Both types of stroke can be fatal. Cerebral arteriosclerosis is also related to a condition known as vascular dementia, in which small, symptom-free strokes cause cumulative damage and death to neurons (nerve cells) in the brain. Personality changes in the elderly, such as apathy, weeping, transient befuddlement, or irritability, might indicate that cerebral arteriosclerosis is present in the brain. Computer tomography (CT) and magnetic resonance imaging (MRI) of the brain can help reveal the presence of cerebral arteriosclerosis before ischemic strokes, hemorrhagic strokes, or vascular dementia develop.

MalaCards based summary : Cerebral Arteriosclerosis is related to arteriosclerosis and cerebral atherosclerosis. An important gene associated with Cerebral Arteriosclerosis is CALCA (Calcitonin Related Polypeptide Alpha). The drugs Mecamylamine and Ethanol have been mentioned in the context of this disorder. Affiliated tissues include brain, testes and cortex.

Related Diseases for Cerebral Arteriosclerosis

Graphical network of the top 20 diseases related to Cerebral Arteriosclerosis:



Diseases related to Cerebral Arteriosclerosis

Symptoms & Phenotypes for Cerebral Arteriosclerosis

Drugs & Therapeutics for Cerebral Arteriosclerosis

Drugs for Cerebral Arteriosclerosis (from DrugBank, HMDB, Dgidb, PharmGKB, IUPHAR, NovoSeek, BitterDB):

(show all 8)
# Name Status Phase Clinical Trials Cas Number PubChem Id
1
Mecamylamine Approved, Investigational Phase 2 60-40-2 4032
2
Ethanol Approved Phase 2 64-17-5 702
3 Antihypertensive Agents Phase 2
4 Neurotransmitter Agents Phase 2
5 Cholinergic Agents Phase 2
6 Cholinergic Antagonists Phase 2
7 Antidepressive Agents Phase 2
8
Serotonin Investigational, Nutraceutical Phase 2 50-67-9 5202

Interventional clinical trials:


# Name Status NCT ID Phase Drugs
1 Treatment With Mecamylamine in Smoking and Non-smoking Alcohol Dependent Patients Completed NCT00342563 Phase 2 mecamylamine;Placebo
2 A Double-Blind,Randomized,Placebo-Controlled Trial of Mecamylamine Hydrochloride for the Treatment of SSRI-Refractory Major Depressive Disorder. Completed NCT00319319 Phase 2 Mecamylamine hydrochloride (Inversine)

Search NIH Clinical Center for Cerebral Arteriosclerosis

Genetic Tests for Cerebral Arteriosclerosis

Anatomical Context for Cerebral Arteriosclerosis

MalaCards organs/tissues related to Cerebral Arteriosclerosis:

40
Brain, Testes, Cortex, Heart, Bone Marrow, Bone, Whole Blood

Publications for Cerebral Arteriosclerosis

Articles related to Cerebral Arteriosclerosis:

(show top 50) (show all 442)
# Title Authors PMID Year
1
Effects of lncRNA gm4419 on rats with hypertensive cerebral atherosclerosis through NF-κB pathway. 61
31858567 2019
2
Suitability of intravascular imaging for assessment of cerebrovascular diseases. 61
31203414 2019
3
Serum Aldosterone Is Associated with Cerebral Artery Atherosclerosis and Calcification. 61
30528672 2019
4
Cerebellopontine Angle Tumors Are Associated with a Greater Incidence of Unruptured Intracranial Aneurysms. 61
31108072 2019
5
Glycated serum proteins: High in pancreatic cancer and low in preeclampsia. 61
30905460 2019
6
Associations of severity of fatty liver with oxidative stress, SAA, CRP and degree of cerebral arteriosclerosis in cerebral arteriosclerosis patients who have fatty liver. 61
31934140 2019
7
Evaluation of the antithrombotic activity of Zhi-Xiong Capsules, a Traditional Chinese Medicinal formula, via the pathway of anti-coagulation, anti-platelet activation and anti-fibrinolysis. 61
29793324 2018
8
Proteomic analysis and comparison of intra‑ and extracranial cerebral atherosclerosis responses to hyperlipidemia in rabbits. 61
28677755 2017
9
Neurological outcomes of antidiabetic therapy: What the neurologist should know. 61
28477558 2017
10
Relation of serum homocysteine levels to cerebral artery calcification and atherosclerosis. 61
27760401 2016
11
Barostim Implantation with Ipsilateral Carotid Endarterectomy as a One-Stage Procedure. 61
27423727 2016
12
[Association of extracellular superoxide dismutase gene methylation with cerebral infarction]. 61
27264826 2016
13
Persimmon (Diospyros kaki L.) leaves: a review on traditional uses, phytochemistry and pharmacological properties. 61
25637828 2015
14
The clinical research for Ganoderan's effect on preventing and treating cerebral arteriosclerosis through inhibiting NADPH oxidizing enzyme expression. 61
25016275 2014
15
Atherosclerosis and arteriosclerosis parameters in stroke patients associate with paraoxonase polymorphism and esterase activities. 61
23305304 2013
16
[Study on clinical efficacy of zhennaoning capsules in treatment of cerebral arteriosclerosis and analysis on its economic benefits]. 61
23944044 2013
17
Niaspan attenuates the adverse effects of bone marrow stromal cell treatment of stroke in type one diabetic rats. 61
24303036 2013
18
Investigation into the anti-thrombosis effect and contents of total saponins and flavonoids in the bioactive fraction of Naodesheng prescription. 61
22982395 2012
19
In vivo pharmacokinetic comparisons of ferulic acid and puerarin after oral administration of monomer, medicinal substance aqueous extract and Nao-De-Sheng to rats. 61
24082627 2012
20
[Diagnostic value of transcranial Doppler ultrasound in early stage cerebral arteriosclerosis]. 61
22659663 2012
21
[Clinical screening of patients with cerebral arteriosclerosis combined with vertebral artery abnormalies]. 61
22712371 2012
22
[Expression of sCD40L in peripheral blood and NF-κBp65 in PBMC of patients with acute progressive cerebral infarction]. 61
21315050 2011
23
Effect of route of administration on the pharmacokinetics and toxicokinetics of cinnarizine in dogs. 61
20307656 2010
24
Safety considerations of fluoroquinolones in the elderly: an update. 61
20210367 2010
25
Diseases and motor vehicle fatalities in Finland in 2001 and 2002. 61
17710723 2007
26
[Clinical analysis of 73 cases of hypoglycemia with brain dysfunctions]. 61
16361175 2005
27
[Observation of the cognition and the velocities of blood in the brain in cerebral arteriosclerosis and infarct patients]. 61
16161271 2005
28
The underdiagnosis of the vascular contribution to dementia. 61
15760612 2005
29
[Clinical observation on effect of yangxue qingnao granule in treating patients with cerebral arteriosclerosis]. 61
15074084 2004
30
[Psychiatric disorders of vascular genesis in women who committed crimes]. 61
17051707 2004
31
[Effect of tianlong xifeng granule on gan-yang-hua-feng zheng in cerebral arteriosclerosis]. 61
14653130 2003
32
Smooth muscle cells and the pathogenesis of cerebral microvascular disease ("angiomyopathies"). 61
12710946 2003
33
Cerebral arteriosclerosis in an aged captive polar bear (Ursus maritimus). 61
12564538 2002
34
Clasmatodendrosis correlating with periventricular hyperintensity in mixed dementia. 61
12205656 2002
35
Magnetic resonance imaging findings and postoperative neurologic dysfunction in elderly patients undergoing coronary artery bypass grafting. 61
11465168 2001
36
[Stroke related knowledge, attitude and behavior of Chinese health professionals]. 61
11798588 2001
37
[An investigation on risk factors of cerebral arteriosclerosis]. 61
11789168 2000
38
[Clinical characteristics and indications for shunting in patients with idiopathic normal pressure hydrocephalus with brain atrophy (atypical idiopathic normal pressure hydrocephalus)]. 61
10875107 2000
39
A preliminary investigation of Tanakan in the treatment of hypertensive arteriosclerosis and stroke in rats. 61
11776097 2000
40
Acetazolamide reactivity in atherothrombotic, cardioembolic and lacunar infarctions. 61
10750358 2000
41
Indications for shunting in patients with idiopathic normal pressure hydrocephalus presenting with dementia and brain atrophy (atypical idiopathic normal pressure hydrocephalus). 61
10721254 2000
42
[The psychoneurological characteristics of the initial manifestations of cerebral arteriosclerosis in sailors]. 61
10701359 2000
43
The reported clinical utility of taurine in ischemic disorders may reflect a down-regulation of neutrophil activation and adhesion. 61
10608263 1999
44
[Orthostatic transient unresponsiveness in an elderly patient with severe cerebral arteriosclerosis under antihypertensive medication]. 61
10586624 1999
45
[Changes in visualization of cerebral MR angiography with normal aging]. 61
10226285 1999
46
[The morphofunctional changes in the erythrocytes in cerebral vascular lesions in patients with hypertension and cerebral arteriosclerosis]. 61
10204336 1998
47
[Occurrence, causes and clinical characteristics of status epilepsy in adults]. 61
9720354 1998
48
Status of treatment of vascular dementia. 61
9549719 1998
49
[The observation of edema in the substantia alba during postoperative brain irradiation. The role of computed tomographic studies]. 61
9463559 1998
50
The impact of age-related changes in event-related P300 potentials on detecting early cognitive dysfunction. 61
15374098 1997

Variations for Cerebral Arteriosclerosis

Expression for Cerebral Arteriosclerosis

Search GEO for disease gene expression data for Cerebral Arteriosclerosis.

Pathways for Cerebral Arteriosclerosis

GO Terms for Cerebral Arteriosclerosis

Sources for Cerebral Arteriosclerosis

3 CDC
7 CNVD
9 Cosmic
10 dbSNP
11 DGIdb
17 EFO
18 ExPASy
19 FMA
28 GO
29 GTR
30 HMDB
31 HPO
32 ICD10
33 ICD10 via Orphanet
34 ICD9CM
35 IUPHAR
36 KEGG
37 LifeMap
39 LOVD
41 MedGen
43 MeSH
44 MESH via Orphanet
45 MGI
48 NCI
49 NCIt
50 NDF-RT
53 NINDS
54 Novoseek
56 OMIM
57 OMIM via Orphanet
61 PubMed
63 QIAGEN
68 SNOMED-CT via HPO
69 TGDB
70 Tocris
71 UMLS
72 UMLS via Orphanet
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